Sterilization equipment for injection production and sterilization process thereof

Abstract

The invention belongs to the technical field of sterilization, and particularly relates to sterilization equipment for injection production and a sterilization process thereof.The sterilization equipment comprises infusion equipment, a sterilization component is arranged at the bottom of the infusion equipment, a guide conveying line is arranged at the axis of the inner wall of the sterilization component, and containing test tubes are evenly arranged on the inner wall of the guide conveying line; and adaptive clamping grooves for fixedly accommodating the bottom ends of the test tubes are formed in the bottom of the guide conveying line. According to the device, the heating inner core at the axis is used for carrying out high-temperature sterilization work on a medicament in each sealed inner tube, and then the sterilized medicament in each sealed inner tube is intensively added into the accommodating test tube transported at the bottom through the discharge component at the bottom, so that the medicament can be sterilized under the condition that the total amount of the added sterilized medicament is not changed; according to the sterilization device, the medicament can be quickly transferred under the condition of no secondary pollution, so that the dispersed medicament can be fully and quickly sterilized in the heat insulation sleeve, and the sterilization working efficiency is further improved.

Description

Technical Field

[0001] The invention belongs to the technical field of sterilization, in particular to a sterilization device for injection production and a sterilization process thereof. Background Art

[0002] The production process of Bumetanide Injection includes preparation, filtration, filling, sterilization, light leak detection, and packaging. Among them, liquid preparation, filtration, filling, and sterilization are key process steps. Changes in the process may affect product quality. Through risk assessment of key process steps, possible risk points are identified, and corresponding control measures are taken for these risk points. The control effect is determined by process verification to ensure product quality.

[0003] According to the decision tree for the selection of sterilization process for injections, the sterilization process for 15 minutes at an ambient temperature of 121 degrees Celsius is preferred, and F0≥12 is controlled to ensure that the sterility level of the product reaches the optimal state. However, during the sterilization process, the medicine needs to be placed in a bottle and sealed to ensure that the medicine will not be contaminated again when it is transported from the sterilization equipment. This results in a small total amount of medicine sterilized at a time, and the transfer is more cumbersome, resulting in low work efficiency, so improvements are needed. Summary of the invention

[0004] In view of the deficiencies of the prior art, the technical solution adopted by the present invention to solve the technical problems is: a sterilization device for injection production, including an infusion device, a sterilization component is arranged at the bottom of the infusion device, a guide transport line is arranged at the axis of the inner wall of the sterilization component, and the inner wall of the guide transport line is evenly provided with accommodating test tubes, and an adapter card slot for fixing the bottom end of the accommodating test tube is opened at the bottom of the guide transport line to ensure that the guide transport line can stably transport the accommodating test tube in a vertical state, and the accommodating test tube whose right side has been filled needs to be sealed in time;

[0005] The infusion device comprises an isolation top plate, a shunt top cylinder is fixedly connected at the axis center of the top of the inner cavity of the isolation top plate, shunt branches are evenly arranged at the bottom of the inner cavity of the shunt top cylinder, a transfer guide tube is inserted at the bottom of the inner wall of the shunt branch, a rotating sleeve is fixedly connected to the middle of the inner wall of the shunt branch, and a flow meter is fixedly connected to the bottom of the inner cavity of the rotating sleeve. When the liquid medicine passes through the rotating sleeve, it passes through the inside of the rotating sleeve, so that the flow meter can monitor the flow of the medicine entering the device;

[0006] The sterilization component includes a processing chamber, a heating core is arranged at the axis center of the inner cavity of the processing chamber, a discharge component is arranged on the lower surface of the processing chamber, a perfusion device is arranged at the axis center of the bottom of the inner wall of the discharge component, and the bottom end of the discharge component is fixedly connected to a support base.

[0007] Furthermore, the processing chamber includes an insulating sleeve, the inner wall of the insulating sleeve is evenly provided with sealed inner tubes, the top of the inner wall of the sealed inner tube is fixedly connected to a propulsion motor, the bottom end of the output shaft of the propulsion motor is fixedly connected to a piston inner tube, and the bottom of the inner wall of the sealed inner tube is inserted with a closed bottom cover, the bottom outer contour of the closed bottom cover is relatively large, and the bottom opening of the insulating sleeve can be completely blocked, and the bottom of the outer surface of the closed bottom cover is rotatably connected to a control shaft through an adapter plate, and both ends of the control shaft are fixedly connected to the outer surface of the insulating sleeve through a fixed frame, and the volume of the medicine diverted to the inside of the sealed inner tube is relatively small, so that a more sufficient sterilization work can be carried out and the heat is more uniform. The bottom end of the transfer guide tube extends to the interior of the sealed inner tube through the through-port, the top end of the heating inner core is fixedly connected to the top of the inner wall of the insulation sleeve, the axis of the lower surface of the isolation top plate is fixedly connected to the axis of the top of the insulation sleeve, the top end of the sealed inner tube is fixedly connected to the top of the inner wall of the insulation sleeve, and the bottom end of the sealed inner tube is fixedly connected to the bottom of the inner wall of the insulation sleeve through the discharge port.

[0008] Furthermore, the discharge component includes a closed bottom cylinder, discharge switches are symmetrically arranged on both sides of the inner wall of the closed bottom cylinder, sleeve bottom cylinders are symmetrically arranged on both sides of the lower surface of the closed bottom cylinder, a tension slide rod is slidably connected to the axis of the inner wall of the sleeve bottom cylinder, the bottom end of the tension slide rod is slidably connected to the control sleeve, and a bridge soft belt is fixedly connected to the lower part of the inner cavity of the sleeve bottom cylinder, the sterilized medicine will be temporarily stored in the interior of the closed bottom cylinder, under normal circumstances, the highest position of the liquid level will be flush with the top of the discharge switch, and the discharge switch will block the only formula port at the bottom of the closed bottom cylinder, so the closed bottom cylinder has a storage effect.

[0009] Furthermore, the lower part of the outer surface of the heating inner core is fixedly connected to the axis of the inner cavity of the closed bottom cylinder, the top of the sleeve bottom cylinder is fixedly connected to the lower surface of the closed bottom cylinder through a slot, the outer surface of the control sleeve is fixedly connected to the inner wall of the support base, the outer surface of the guide transport line is slidingly connected to the axis of the inner wall of the support base, a vertical groove is opened at the top of the inner cavity of the closed bottom cylinder, and the outer surface of the adapter plate is rotatably connected to the inner wall of the vertical groove through a closed soft belt.

[0010] Furthermore, the discharge switch includes a sliding inner shell, the inner cavity of the sliding inner shell is evenly provided with connecting grooves, the outer surface of the sliding inner shell is sleeved with an inner sealing soft belt, the bottom end of the sliding inner shell is fixedly connected with a clamping bottom block, the top end of the tension slide rod is clamped with the inner wall of the clamping bottom block, the lower surface of the inner sealing soft belt is fixedly connected with the inner wall of the closed bottom cylinder, the outer surface of the clamping bottom block is slidably connected with the bottom of the inner cavity of the closed bottom cylinder through a through opening, after the tension slide rod slides down, the height of the sliding inner shell will drop, at this time the liquid inside the closed bottom cylinder will enter the sliding inner shell and then be discharged into the interior of the sleeve bottom cylinder through the connecting groove.

[0011] Furthermore, the pouring device comprises an axial discharge shell, the top of the inner wall of the axial discharge shell is fixedly connected to a traction motor, the bottom end of the output shaft of the traction motor is fixedly connected to an axial piston, the top of the inner wall of the axial piston is fixedly connected to a folding jacket, and the inner cavity of the folding jacket is evenly provided with drainage openings. Figure 8 The folding jacket is shown in a stretched state, at which time its drainage opening will be opened. When the bottom end of the axial piston blocks the opening at the bottom of the axial discharge shell, the folding jacket is compressed, so the drainage opening will also be blocked. The end of the bridge soft belt away from the sleeve bottom cylinder is fixedly connected to the bottom of the inner cavity of the axial discharge shell, the upper surface of the axial discharge shell is fixedly connected to the axis of the lower surface of the closed bottom cylinder through an elastic pressure plate, and the bottom end of the folding jacket is fixedly connected to the axis of the bottom of the inner wall of the axial discharge shell through a drainage port.

[0012] The beneficial effects of the present invention are as follows:

[0013] 1. The device can evenly distribute a large amount of injection added to the internal sealed inner tube through the transfer guide tube at the top, and use the heating inner core at the axis to perform high-temperature sterilization on the medicine inside each sealed inner tube, and then use the discharge component at the bottom to concentrate the sterilized medicine inside each sealed inner tube into the containing test tube for transportation at the bottom. While ensuring that the total amount of sterilized medicine added remains unchanged, the medicine can be quickly transferred without secondary contamination, so that the dispersed medicine can be sterilized more fully and quickly inside the insulation sleeve, thereby improving the sterilization efficiency.

[0014] 2. When the medicine dispersed in the sealed inner tube is being sterilized, the piston inner cylinder on the top can block the side opening, thereby preventing the heat energy generated by sterilization from flowing back into the infusion equipment through the transfer guide tube and causing heat loss. When draining, the piston inner cylinder can pressurize and discharge the residual medicine liquid attached to the inner wall of the sealed inner tube, thereby increasing the transfer speed of the medicine and reducing the residual amount of medicine on the inner wall of the sealed inner tube, preventing the problem of chemical properties of some medicines changing due to continuous sterilization for a long time.

[0015] 3. When the reagent is poured into the containing test tube, the filling speed will be faster because the reagent is subjected to strong pressure. The axial discharge shell at the bottom can press down and tighten the top of the containing test tube under the elastic squeezing action of the elastic pressure plate, so that the reagent sprayed from the nozzle at the bottom of the axial discharge shell will not splash from the inside of the containing test tube to the outside due to excessive impact force, thereby polluting the environment.

[0016] 4. When the filling equipment is not discharging, the bottom end of the axial piston will completely block the bottom opening of the axial discharge shell. At this time, the folding jacket is in an extreme compression state, and its drainage opening is completely blocked. When discharging, its drainage opening is also opened. When the test tube is about to be filled, the axial piston will reset. At this time, the folding jacket will further squeeze and spray out the residual medicine inside during the compression process, thereby reducing the problem of residual medicine at the bottom of the axial discharge shell and avoiding the medicine from dripping onto the guide transport line. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a front view of the sterilization equipment for injection production of the present invention;

[0018] Figure 2 is a cross-sectional view of a sterilization device for injection production of the present invention;

[0019] Figure 3 is a cross-sectional view of the infusion device of the present invention;

[0020] Figure 4 is a cross-sectional view of the sterilization component of the present invention;

[0021] Figure 5 is a cross-sectional view of a processing chamber of the present invention;

[0022] Figure 6 is a cross-sectional view of the discharge component of the present invention;

[0023] Figure 7 is a cross-sectional view of the discharge switch of the present invention;

[0024] Figure 8 is a cross-sectional view of the perfusion device of the present invention;

[0025] Fig. 9 It is a flow chart of the sterilization process for producing the injection of the present invention.

[0026] In the figure: 1. Infusion equipment; 2. Sterilization components; 3. Guide transport line; 4. Hold test tubes; 11. Isolation top plate; 12. Diversion top cylinder; 13. Diversion branch pipe; 14. Transfer guide pipe; 15. Rotating sleeve; 16. Flow meter; 21. Processing chamber; 22. Heating inner core; 23. Support base; 211. Insulation sleeve; 212. Sealing inner tube; 213. Propulsion motor; 214. Piston inner cylinder; 215. Closed bottom cover; 216. Control shaft ; 217, closed soft belt; 218, fixed frame; 5, discharge component; 51, closed bottom cylinder; 52, discharge switch; 53, sleeve bottom cylinder; 54, tension slide rod; 55, control sleeve; 56, bridge soft belt; 521, sliding inner shell; 522, connecting groove; 523, inner sealing soft belt; 524, snap-on bottom block; 6, pouring equipment; 61, axial discharge shell; 62, traction motor; 63, axial piston; 64, folding outer sleeve; 65, drainage port. DETAILED DESCRIPTION

[0027] The present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. The embodiments of the present invention are provided for the purpose of illustration and description, and are not intended to be exhaustive or to limit the present invention to the disclosed forms. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments are selected and described in order to better illustrate the principles and practical applications of the present invention, and to enable those of ordinary skill in the art to understand the present invention and thereby design various embodiments with various modifications suitable for specific uses.

[0028] Example 1, please refer to Figure 1-Figure 5 The present invention provides a technical solution: a sterilization device for injection production, comprising an infusion device 1, a sterilization component 2 is arranged at the bottom of the infusion device 1, a guide transport line 3 is arranged at the axis of the inner wall of the sterilization component 2, and a receiving test tube 4 is evenly arranged on the inner wall of the guide transport line 3, and an adapter card slot for fixing the bottom end of the receiving test tube 4 is opened at the bottom of the guide transport line 3 to ensure that the guide transport line 3 can stably transport the receiving test tube 4 in a vertical state, and the receiving test tube 4 on the right side of which has been filled needs to be sealed in time;

[0029] The infusion device 1 includes an isolation top plate 11, a shunt top cylinder 12 is fixedly connected to the axis of the top of the inner cavity of the isolation top plate 11, shunt branches 13 are evenly arranged at the bottom of the inner cavity of the shunt top cylinder 12, a transfer guide tube 14 is inserted at the bottom of the inner wall of the shunt branch 13, a rotating sleeve 15 is fixedly connected to the middle of the inner wall of the shunt branch 13, and a flow meter 16 is fixedly connected to the bottom of the inner cavity of the rotating sleeve 15. When the liquid medicine passes through the rotating sleeve 15, it will pass through the inside of the rotating sleeve 15, so that the flow meter 16 can monitor the flow of the medicine entering the device;

[0030] The sterilization component 2 includes a treatment chamber 21, a heating core 22 is arranged at the axis center of the inner cavity of the treatment chamber 21, a discharge component 5 is arranged on the lower surface of the treatment chamber 21, a perfusion device 6 is arranged at the axis center of the bottom of the inner wall of the discharge component 5, and the bottom end of the discharge component 5 is fixedly connected to a support base 23.

[0031] The processing chamber 21 includes a heat-insulating sleeve 211, the inner wall of which is evenly provided with a sealed inner tube 212, the top of the inner wall of the sealed inner tube 212 is fixedly connected to a propulsion motor 213, the bottom end of the output shaft of the propulsion motor 213 is fixedly connected to a piston inner tube 214, and the bottom of the inner wall of the sealed inner tube 212 is plugged with a closed bottom cover 215, the bottom outer contour of the closed bottom cover 215 is relatively large, and the bottom opening of the heat-insulating sleeve 211 can be completely blocked, and the bottom of the outer surface of the closed bottom cover 215 is rotatably connected to a control shaft 216 through an adapter plate, and both ends of the control shaft 216 are fixedly connected to the outer surface of the heat-insulating sleeve 211 through a fixed frame 218, and the volume of the medicine diverted to the inside of the sealed inner tube 212 is relatively small, so a more sufficient sterilization work can be carried out and the heat is more uniform. The bottom end of the transfer guide tube 14 extends to the interior of the sealed inner tube 212 through the through opening, the top end of the heating inner core 22 is fixedly connected to the top of the inner wall of the insulation sleeve 211, the axis of the lower surface of the isolation top plate 11 is fixedly connected to the axis of the top of the insulation sleeve 211, the top end of the sealed inner tube 212 is fixedly connected to the top of the inner wall of the insulation sleeve 211, and the bottom end of the sealed inner tube 212 is fixedly connected to the bottom of the inner wall of the insulation sleeve 211 through the discharge port.

[0032] The medicine to be sterilized is introduced into the interior of the device through the diversion top tube 12 at the top, and then the medicine is evenly distributed to each transfer guide tube 14 through the diversion effect of the diversion branch tube 13. When the medicine passes through the rotating sleeve 15, it will be monitored by the flow meter 16. When the medicine introduced into each diversion branch tube 13 reaches the predetermined capacity of the sealed inner tube 212, the flow meter 16 will sound an alarm. At this time, the addition of medicine is temporarily stopped, and the introduced medicine will be transported to the interior of the sealed inner tube 212 through the transfer guide tube 14 to fill the interior of the sealed inner tube 212.

[0033] During sterilization, the axial heating core 22 heats the sealed inner tube 212 inside the insulation sleeve 211, and the propulsion motor 213 pushes the piston inner tube 214 slightly downward to block the bottom end of the transfer guide tube 14 to prevent heat leakage. After fifteen minutes of heating, the control shaft 216 at the bottom uniformly deflects to open the closed bottom cover 215 and open the bottom opening of the insulation sleeve 211. At this time, the sterilized medicine will enter the discharge component 5 below and wait for discharge.

[0034] There is a directional sliding guide transport line 3 at the axis of the support base 23, and the discharge component 5 adds the sterilization agent stored inside into the transported containing test tube 4 in sequence to complete the sterilization processing of the drug solution.

[0035] Example 2, please refer to Figure 1-Figure 9 The present invention provides a technical solution: on the basis of Example 1, the discharge component 5 includes a closed bottom cylinder 51, and discharge switches 52 are symmetrically arranged on both sides of the inner wall of the closed bottom cylinder 51, and sleeve bottom cylinders 53 are symmetrically arranged on both sides of the lower surface of the closed bottom cylinder 51. A tension slide bar 54 is slidably connected to the axis of the inner wall of the sleeve bottom cylinder 53, and a control sleeve 55 is slidably connected to the bottom end of the tension slide bar 54. A bridge soft belt 56 is fixedly connected to the lower part of the inner cavity of the sleeve bottom cylinder 53. The sterilized medicine will be temporarily stored in the inside of the closed bottom cylinder 51. Under normal circumstances, the highest position of the liquid level will be flush with the top of the discharge switch 52, and the discharge switch 52 will block the only formula port at the bottom of the closed bottom cylinder 51, so the closed bottom cylinder 51 has a storage effect.

[0036] The lower part of the outer surface of the heating core 22 is fixedly connected to the axis center of the inner cavity of the closed bottom cylinder 51, the top of the sleeve bottom cylinder 53 is fixedly connected to the lower surface of the closed bottom cylinder 51 through a slot, the outer surface of the control sleeve 55 is fixedly connected to the inner wall of the support base 23, the outer surface of the guide transport line 3 is slidingly connected to the axis center of the inner wall of the support base 23, a vertical groove is opened at the top of the inner cavity of the closed bottom cylinder 51, and the outer surface of the adapter plate is rotatably connected to the inner wall of the vertical groove through a closed soft belt 217.

[0037] The discharge switch 52 includes a sliding inner shell 521, the inner cavity of the sliding inner shell 521 is evenly provided with connecting grooves 522, the outer surface of the sliding inner shell 521 is sleeved with an inner sealing soft belt 523, the bottom end of the sliding inner shell 521 is fixedly connected with a clamping bottom block 524, the top end of the tension slide bar 54 is clamped with the inner wall of the clamping bottom block 524, the lower surface of the inner sealing soft belt 523 is fixedly connected with the inner wall of the closed bottom cylinder 51, the outer surface of the clamping bottom block 524 is slidably connected with the bottom of the inner cavity of the closed bottom cylinder 51 through a through opening, after the tension slide bar 54 slides down, the height of the sliding inner shell 521 will drop, at this time the liquid inside the closed bottom cylinder 51 will enter the sliding inner shell 521 and then be discharged to the inside of the sleeve bottom cylinder 53 through the connecting groove 522.

[0038] The filling device 6 includes an axial discharge shell 61, a traction motor 62 is fixedly connected to the top of the inner wall of the axial discharge shell 61, an axial piston 63 is fixedly connected to the bottom end of the output shaft of the traction motor 62, a folding jacket 64 is fixedly connected to the top of the inner wall of the axial piston 63, and the inner cavity of the folding jacket 64 is evenly provided with drainage openings 65. Figure 8The folding jacket 64 is shown in a stretched state, at which time its drainage port 65 will be opened. When the bottom end of the axial piston 63 blocks the through hole at the bottom of the axial discharge shell 61, the folding jacket 64 is compressed, so the drainage port 65 will also be blocked. The end of the bridge soft belt 56 away from the sleeve bottom cylinder 53 is fixedly connected to the bottom of the inner cavity of the axial discharge shell 61, the upper surface of the axial discharge shell 61 is fixedly connected to the axis of the lower surface of the closed bottom cylinder 51 through an elastic pressure plate, and the bottom end of the folding jacket 64 is fixedly connected to the axis of the bottom of the inner wall of the axial discharge shell 61 through a drainage port.

[0039] The working state of the discharge component 5 is as follows: the medicine entering the closed bottom cylinder 51 will gradually fill the internal space of the closed bottom cylinder 51. When the medicine needs to be discharged, the tension slide rods 54 on both sides pull the clamping bottom block 524 downward under the control of the control sleeve 55. At this time, the medicine inside the closed bottom cylinder 51 will enter the interior of the sleeve bottom cylinder 53 through the connecting groove 522, and then the medicine will be transported to the perfusion device 6 through the bridge soft belt 56. Since the perfusion device 6 will press down the containing test tube 4 below during the filling operation to further fix the containing test tube 4, the perfusion device 6 will drop slightly at this time, and the bridge soft belts 56 on both sides will not only deform and stretch, but also deflect obliquely downward, making it easier to drain the medicine inside the sleeve bottom cylinder 53 into the axial discharge shell 61.

[0040] When the filling device 6 is not discharging, the bottom end of the axial piston 63 will completely block the bottom opening of the axial discharge shell 61. At this time, the folding jacket 64 is in an extreme compression state, and its drainage opening 65 is completely blocked. The axial discharge shell 61 can only receive the medicine from the bridge soft belt 56. When discharging, the filling device 6 is in a state such as Figure 8 As shown, the traction motor 62 first pulls the axial piston 63 upwards, at which time the bottom opening of the axial discharge shell 61 is opened, the folding sleeve 64 is stretched, and the drainage opening 65 is also opened, and the medicine inside the axial discharge shell 61 is discharged into the lower containing test tube 4 through the drainage opening 65. When the containing test tube 4 is about to be filled, the axial piston 63 is reset, and at this time the folding sleeve 64 will further squeeze and spray out the remaining medicine inside during the compression process.

[0041] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field and related fields without creative work should fall within the scope of protection of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention are implemented according to the conventional means in the field unless otherwise specified and limited.

Claims

1. A sterilization device for injection production, comprising an infusion device (1), a sterilization component (2) is arranged at the bottom of the infusion device (1), a guide transport line (3) is arranged at the axis of the inner wall of the sterilization component (2), and the inner wall of the guide transport line (3) is evenly provided with accommodating test tubes (4), characterized in that: The infusion device (1) comprises an isolation top plate (11), a flow dividing top cylinder (12) is fixedly connected to the axis center of the top of the inner cavity of the isolation top plate (11), flow dividing branches (13) are evenly arranged at the bottom of the inner cavity of the flow dividing top cylinder (12), a transfer guide tube (14) is inserted at the bottom of the inner wall of the flow dividing branch tube (13), a rotating sleeve (15) is fixedly connected to the middle of the inner wall of the flow dividing branch tube (13), and a flow meter (16) is fixedly connected to the bottom of the inner cavity of the rotating sleeve (15); The sterilization component (2) comprises a treatment chamber (21), a heating core (22) is arranged at the axis center of the inner cavity of the treatment chamber (21), a discharge component (5) is arranged on the lower surface of the treatment chamber (21), a perfusion device (6) is arranged at the axis center of the bottom of the inner wall of the discharge component (5), and the bottom end of the discharge component (5) is fixedly connected to a support base (23).

2. The sterilization equipment for injection production according to claim 1, characterized in that: The processing chamber (21) comprises a heat-insulating sleeve (211), the inner wall of which is evenly provided with a sealed inner tube (212), the top of the inner wall of the sealed inner tube (212) is fixedly connected to a propulsion motor (213), the bottom end of the output shaft of the propulsion motor (213) is fixedly connected to a piston inner tube (214), the bottom of the inner wall of the sealed inner tube (212) is plugged with a closed bottom cover (215), the bottom of the outer surface of the closed bottom cover (215) is rotatably connected to a control shaft (216) via an adapter plate, and both ends of the control shaft (216) are fixedly connected to the outer surface of the heat-insulating sleeve (211) via a fixing frame (218).

3. The sterilization equipment for injection production according to claim 2, characterized in that: The bottom end of the transfer guide tube (14) extends to the interior of the sealed inner tube (212) through the through opening, the top end of the heating inner core (22) is fixedly connected to the top of the inner wall of the heat insulating sleeve (211), the axis of the lower surface of the isolation top plate (11) is fixedly connected to the axis of the top of the heat insulating sleeve (211), the top end of the sealed inner tube (212) is fixedly connected to the top of the inner wall of the heat insulating sleeve (211), and the bottom end of the sealed inner tube (212) is fixedly connected to the bottom of the inner wall of the heat insulating sleeve (211) through the discharge port.

4. The sterilization equipment for injection production according to claim 2, characterized in that: The discharge component (5) comprises a closed bottom cylinder (51), discharge switches (52) are symmetrically arranged on both sides of the inner wall of the closed bottom cylinder (51), sleeve bottom cylinders (53) are symmetrically arranged on both sides of the lower surface of the closed bottom cylinder (51), a tension slide bar (54) is slidably connected to the axis of the inner wall of the sleeve bottom cylinder (53), a control sleeve (55) is slidably connected to the bottom end of the tension slide bar (54), and a bridge soft belt (56) is fixedly connected to the lower part of the inner cavity of the sleeve bottom cylinder (53).

5. The sterilization equipment for injection production according to claim 4, characterized in that: The lower part of the outer surface of the heating inner core (22) is fixedly connected to the axis center of the inner cavity of the closed bottom cylinder (51), the top end of the sleeve bottom cylinder (53) is fixedly connected to the lower surface of the closed bottom cylinder (51) through a slot, the outer surface of the control sleeve (55) is fixedly connected to the inner wall of the support base (23), the outer surface of the guide transport line (3) is slidably connected to the inner wall of the support base (23) at the axis center, a vertical groove is opened at the top of the inner cavity of the closed bottom cylinder (51), and the outer surface of the adapter plate is rotatably connected to the inner wall of the vertical groove through a closed soft belt (217).

6. The sterilization equipment for injection production according to claim 5, characterized in that: The discharge switch (52) comprises a sliding inner shell (521), the inner cavity of the sliding inner shell (521) is evenly provided with connecting grooves (522), the outer surface of the sliding inner shell (521) is sleeved with an inner sealing soft belt (523), the bottom end of the sliding inner shell (521) is fixedly connected with a clamping bottom block (524), the top end of the tension slide rod (54) is clamped with the inner wall of the clamping bottom block (524), the lower surface of the inner sealing soft belt (523) is fixedly connected with the inner wall of the closed bottom cylinder (51), and the outer surface of the clamping bottom block (524) is slidably connected with the bottom of the inner cavity of the closed bottom cylinder (51) through a through opening.

7. The sterilization equipment for injection production according to claim 6, characterized in that: The pouring device (6) comprises an axial discharge shell (61), the top of the inner wall of the axial discharge shell (61) is fixedly connected to a traction motor (62), the bottom end of the output shaft of the traction motor (62) is fixedly connected to an axial piston (63), the top of the inner wall of the axial piston (63) is fixedly connected to a folding jacket (64), and the inner cavity of the folding jacket (64) is evenly provided with drainage openings (65).

8. The sterilization equipment for injection production according to claim 7, characterized in that: One end of the bridge frame soft belt (56) away from the sleeve bottom tube (53) is fixedly connected to the bottom of the inner cavity of the axial discharge shell (61), the upper surface of the axial discharge shell (61) is fixedly connected to the axis of the lower surface of the closed bottom tube (51) through an elastic pressure plate, and the bottom end of the folding sleeve (64) is fixedly connected to the axis of the bottom of the inner wall of the axial discharge shell (61) through a discharge port.

9. A sterilization process for injection production, characterized in that: The process is as follows: S1: quantitatively passing the medicine to be sterilized into the interior of the split top cylinder (12), and then splitting it to each sealed inner tube (212); S2: Before heating, the bottom opening of the transfer guide tube (14) is blocked by pushing the piston inner tube (214); S3: heating the inner core (22) to heat the interior of the heat insulating sleeve (211) for fifteen minutes; S4: Synchronously opening the closed bottom cover (215) to discharge the sterilizing agent into the closed bottom cylinder (51) for storage; S5: taking out the medicine through the sleeve bottom tube (53) and transferring it to the injection device (6); S6: The filling device (6) sequentially fills the containing test tubes (4) passing below.

Images