Device and method for detecting permeability of oleuropein

Abstract

The invention discloses an oleuropein permeability detection device and method, and relates to the technical field of detection devices.The oleuropein permeability detection device comprises a base, a diffusion pool and a plurality of sets of receiving chamber bottles, the tops of the receiving chamber bottles are provided with supply chamber bottles, the diffusion pool is provided with a transparent plate frame, and the base is provided with a cleaning mechanism; according to the invention, through the designed cleaning mechanism, when a batch of medicines or cosmetics containing oleuropein are detected and then a next batch of different medicines or cosmetics are detected again, only a tool is needed to stretch into a receiving chamber bottle from a sampling tube to extract permeated liquid; then the alcohol disinfection cotton barrels on the rod frame move and descend to enter the receiving chamber bottle, the first inner tooth belt rotates to drive the multiple sets of alcohol disinfection cotton barrels to rotate at the same time, liquid on the inner wall is wiped and disinfected, the receiving chamber bottle does not need to be taken out, operation steps and time are saved, and the working efficiency is improved. The permeability detection efficiency of medicines or cosmetics containing oleuropein is improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of detection devices, and in particular to an oleuropein permeability detection device and method. Background Art

[0002] Oleuropein is an important secoiridoid glycoside compound with multiple pharmacological effects such as antifungal, anti-inflammatory, antiviral, prevention of coronary heart disease, atherosclerosis, relaxation of vascular smooth muscle, antioxidant, anti-cancer and hypoglycemic effects. Olive leaves are rich in active molecules such as polyphenols, flavonoids, flavanoids, substituted phenols, lignans, glycosides, enzymes, secoiridoid derivatives and caffeoylphenylethanol glycosides. The most important active ingredients are oleuropein and hydroxytyrosol (the degradation product of oleuropein), with oleuropein having the highest content. When conducting permeability testing on oleuropein, it will be tested through a testing device, which can accurately evaluate the transdermal absorption performance of drugs, cosmetics or nutrients, and provide reliable data support for the research and development of high-efficiency and low-irritation products.

[0003] In the prior art, a receiving chamber bottle is placed in a diffusion pool in a constant temperature state in a detection device, and then an artificial membrane of an artificial skin substitute is placed on the top of the receiving chamber bottle, and then a supply chamber bottle is covered on the top of the receiving chamber bottle. Then, a drug or cosmetic sample containing oleuropein is inserted into the top of the supply chamber bottle using a tool and smeared on the surface of the artificial membrane. The drug or cosmetic sample on the artificial membrane penetrates the artificial membrane and drips into the receiving chamber bottle. Finally, the amount of liquid in the receiving chamber bottle is measured to detect the oleuropein penetration. However, when a batch of drugs or cosmetics containing oleuropein is tested after completion, when the next batch of different drugs or cosmetics is tested again, it is necessary to remove the transparent plate frame, and then remove the receiving chamber bottle from the cell frame, clean and disinfect the inside of the receiving chamber bottle, and then install it back to the original position. This operation is cumbersome, increases the operation time, and reduces the efficiency of oleuropein detection. For this reason, we propose an oleuropein permeability detection device and method. Summary of the invention

[0004] The object of the present invention is to provide a device and method for detecting oleuropein permeability to solve the technical problems raised in the above-mentioned background technology.

[0005] To achieve the above object, the present invention provides the following technical solution: an oleuropein permeability detection device, comprising a base, a diffusion cell and a plurality of groups of receiving chamber bottles, a supply chamber bottle is arranged on the top of the receiving chamber bottle, a transparent plate rack is arranged on the diffusion cell, and a cleaning mechanism is arranged on the base, and the cleaning mechanism comprises:

[0006] Fixed columns and multiple groups of rod racks, the outside of the rod racks is provided with alcohol disinfection cotton cylinders for wiping and disinfecting the inner walls of the bottles in the receiving chamber;

[0007] A support bearing is sleeved on the outer side of the bottom of the fixed column, a first gear is fixedly arranged on the outer side of the top of the support bearing, and a first internal toothed belt is meshed on the outside of the first gear for driving multiple groups of first gears to rotate simultaneously.

[0008] Preferably, a rotating rod is rotatably arranged inside the fixed column, and a large arc-shaped plate is fixedly arranged at the bottom of the rotating rod;

[0009] A lower ring is fixedly arranged on the outer side of the bottom of the support bearing, a track is arranged at the bottom of the lower ring, a slider is arranged on the track, and a small arc plate is fixedly arranged on the surface of the slider.

[0010] Preferably, a through groove is formed at the bottom of the sliding block, the top of the rod frame is inserted into the through groove, and a locking screw is threadedly connected to the inside of the sliding block.

[0011] Preferably, the cleaning mechanism further comprises a top frame and a middle frame, and two sets of lifting rods are fixedly arranged on the top frame;

[0012] The support bearing is fixed on the middle frame, an L-shaped frame is fixedly arranged on the middle frame, a reduction motor is arranged at the end of the L-shaped frame, and a gear ring is fixedly arranged at the working end of the reduction motor.

[0013] Preferably, slide plates are fixedly provided at both ends of the top frame, a rail frame is provided outside the slide plate, and a support frame is fixedly provided between the bottom of the rail frame and the base.

[0014] Preferably, a driving member is provided on the rail frame for driving the rotating rod to rotate;

[0015] The driving member includes two sets of racks and a second gear fixed to the outer side of the top of the rotating rod. The rail frame is respectively fixed with an L-shaped block and a support block. The L-shaped block is fixed with a hydraulic rod, and the working end of the hydraulic rod is fixed with a connecting frame.

[0016] Preferably, a fixed rail is fixedly provided on the top of the support block, and a sliding rail is fixedly provided on the top of the rack.

[0017] Preferably, the rail frame is provided with a limiting member for limiting the position of the slide plate, the limiting member comprises a convex column fixed on the surface of the slide plate and a concave plate fixed on the surface of the rail frame, a slot is provided inside the convex column, and a limiting rod is slidably provided inside the concave plate;

[0018] An upper plate is fixedly arranged on the top of the limiting rod, and a spring is fixedly arranged between the upper plate and the concave plate.

[0019] Preferably, an artificial membrane is provided between the receiving chamber bottle and the supply chamber bottle, a sampling tube is provided on the receiving chamber bottle, and a plurality of cell racks are fixedly provided inside the diffusion cell.

[0020] The present invention also discloses a detection method of an oleuropein permeability detection device, which specifically comprises the following steps:

[0021] S1, placing the receiving chamber bottle, the artificial membrane and the donor chamber bottle into the diffusion cell;

[0022] S2, applying the medicine or cosmetic containing oleuropein onto the artificial membrane by using a tool, and at the same time turning on the heating device in the diffusion pool to heat the water in the diffusion pool;

[0023] S3, the drug or cosmetic sample containing oleuropein on the artificial membrane penetrates the artificial membrane and drips into the receiving chamber bottle;

[0024] S4. The liquid dripping into the bottle of the receiving chamber is taken out by a tool and the amount of the liquid is measured to complete the permeability test of the medicine or cosmetic containing oleuropein.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] (1) The cleaning mechanism designed in the present invention allows for testing of a batch of drugs or cosmetics containing oleuropein only by inserting a tool from a sampling tube into a receiving chamber bottle to extract the permeated liquid, and then moving and lowering the alcohol disinfection cotton tube on the rod frame into the receiving chamber bottle. The rotation of the first inner toothed belt drives multiple groups of alcohol disinfection cotton tubes to rotate simultaneously to wipe and disinfect the liquid on the inner wall. There is no need to remove the receiving chamber bottle, thereby saving operation steps and time, and improving the efficiency of permeability testing of drugs or cosmetics containing oleuropein.

[0027] (2) The present invention has a designed driving member. When the bottom of the alcohol disinfection cotton tube enters the interior of the receiving chamber bottle, the hydraulic rod drives the rack to move, thereby driving the rotating rod to rotate. Then, under the action of the large arc plate and the small arc plate, the alcohol disinfection cotton tube can be moved toward the inner wall of the receiving chamber bottle and adhered to it. There is no need for personnel to manually rotate the rotating rod to move the alcohol disinfection cotton tube, which is convenient for operation.

[0028] (3) The present invention adopts a designed limiter. When the slide plate in the rail frame is moved toward the top of the diffusion pool to drive the disinfection alcohol cotton tube to move to the position directly above the receiving pool bottle, the slide plate can be limited. This prevents the slide plate from moving in the rail frame and causing instability during the subsequent wiping and disinfection process of the inner wall of the receiving room bottle, thereby improving the wiping and disinfection effect of the receiving room bottle. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a structural schematic diagram of the present invention;

[0030] Figure 2 It is a rear view structural schematic diagram of the present invention;

[0031] Figure 3 It is a bottom view structural schematic diagram of the present invention;

[0032] Figure 4 It is a schematic diagram of the connection structure between the top frame and the lifting rod of the present invention;

[0033] Figure 5 It is a rear view structural schematic diagram of the hydraulic rod of the present invention;

[0034] Figure 6 It is a schematic diagram of the support bearing and the first gear structure of the present invention;

[0035] Figure 7 For the present invention Figure 6 A schematic diagram of the enlarged structure of the middle part A;

[0036] Figure 8 It is a bottom view structural schematic diagram of the support bearing of the present invention;

[0037] Fig. 9 It is a schematic diagram of the L-shaped block and rack structure of the present invention;

[0038] Fig.10 For the present invention Fig. 9 The enlarged structural diagram of the middle B part;

[0039] Fig.11 It is a structural schematic diagram of the diffusion cell of the present invention;

[0040] Fig.12 It is a schematic diagram of the cross-sectional structure of the collection chamber bottle of the present invention;

[0041] Fig.13 It is a schematic diagram of the structure of the concave plate and the limiting rod of the present invention;

[0042] In the figure: 100, base; 101, supply chamber bottle; 102, sampling tube; 103, cover glass; 104, transparent plate rack; 105, receiving chamber bottle; 106, diffusion cell; 107, cell rack; 108, artificial membrane; 200, alcohol disinfection cotton cylinder; 201, lifting rod; 202, rail rack; 203, support frame; 204, middle frame; 205, support bearing; 206, fixed column; 207, first inner tooth belt; 208, L-shaped frame; 210, top frame; 211, lower ring; 212, large arc plate; 213, rotating Rod; 214, small arc plate; 215, rod frame; 216, locking screw; 217, slider; 218, track; 219, reduction motor; 220, gear ring; 221, first gear; 222, slide plate; 223, electric push rod; 300, convex column; 301, concave plate; 302, limit rod; 303, spring; 304, upper plate; 400, hydraulic rod; 401, L-shaped block; 402, connecting frame; 403, rack; 404, sliding rail; 405, second gear; 406, support block; 407, fixed rail. DETAILED DESCRIPTION

[0043] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0044] Embodiment 1

[0045] See also Figure 1-Figure 9 The present invention provides a technical solution: an oleuropein permeability detection device, comprising a base 100, a diffusion cell 106 and a plurality of groups of receiving chamber bottles 105, wherein a heating device is provided in the diffusion cell 106, wherein the heating device is a heater, a supply chamber bottle 101 is provided on the top of the receiving chamber bottle 105, a transparent plate frame 104 is provided on the diffusion cell 106, and a cleaning mechanism is provided on the base 100, wherein the cleaning mechanism comprises a fixed column 206 and a plurality of groups of rod frames 215, wherein an alcohol disinfection cotton cylinder 200 is provided outside the rod frame 215, and the inner wall of the receiving chamber bottle 105 is cleaned by rotating the alcohol disinfection cotton cylinder 200;

[0046] The bottom outer side of the fixed column 206 is sleeved with a support bearing 205, the top outer side of the support bearing 205 is fixedly provided with a first gear 221, the outer side of the first gear 221 is meshed with a first internal toothed belt 207, and the interior of the fixed column 206 is rotatably provided with a rotating rod 213, and the large arc plate 212 at the bottom can be driven to rotate by rotating the rotating rod 213, and the large arc plate 212 is fixedly provided at the bottom of the rotating rod 213;

[0047] A lower ring 211 is fixedly provided on the outer side of the bottom of the support bearing 205, a track 218 is fixedly provided on the bottom of the lower ring 211, a slider 217 is slidably provided on the track 218, a small arc plate 214 is fixedly provided on the surface of the slider 217, an electric push rod 223 and a battery are installed on the top of the track 218, and the electric push rod 223 is powered by the battery. When the alcohol disinfection cotton cylinder 200 moves to contact the inner wall of the receiving chamber bottle 105, the electric push rod 223 is started, and the working end of the electric push rod 223 moves downward and contacts and presses against the upper surface of the slider 217, pressing the slider 217. For limiting, a groove is provided at the bottom of the slider 217, and the top of the rod frame 215 is inserted into the inside of the groove. The inside of the slider 217 is connected with a locking screw 216 through a thread, and the working end of the locking screw 216 extends to the surface of the rod frame 215, and the top of the rod frame 215 is inserted into the groove in the slider 217 and fixed by the locking screw 216. When the alcohol disinfection cotton tube 200 needs to be replaced during use, the locking screw 216 is turned outward to loosen it, and then the rod frame 215 is taken out to remove the alcohol disinfection cotton tube 200, and a new rod frame 215 and alcohol disinfection cotton tube 200 are replaced.

[0048] Embodiment 2

[0049] Based on Example 1, please refer to Figure 1-Figure 9 The cleaning mechanism also includes a top frame 210 and a middle frame 204. Two sets of lifting rods 201 are fixedly arranged on the top frame 210. The lifting rods 201 can drive the middle frame 204 and the alcohol disinfection cotton tube 200 to move downward, and the working end of the lifting rod 201 is fixedly connected to the middle frame 204;

[0050] The support bearing 205 is fixed on the middle frame 204. The support bearing 205 is composed of an inner ring, an outer ring and other structures. The lower ring 211 is fixed to the bottom of the outer ring, and the first gear 221 is fixed to the top of the outer ring. An L-shaped frame 208 is fixed on the middle frame 204. A reduction motor 219 is fixed at the end of the L-shaped frame 208. The reduction motor 219 can drive the first internal toothed belt 207 to rotate. A gear ring 220 is fixed at the working end of the reduction motor 219, and the gear ring 220 is meshed with the first internal toothed belt 207.

[0051] Slide plates 222 are fixedly provided at both ends of the top frame 210 , a rail frame 202 is provided outside the slide plate 222 , the slide plate 222 can slide back and forth inside the rail frame 202 , and a support frame 203 is fixedly provided between the bottom of the rail frame 202 and the base 100 .

[0052] The cleaning mechanism designed in the present invention, when testing a batch of drugs or cosmetics containing oleuropein, is completed, when testing the next batch of different drugs or cosmetics again, it is only necessary to extend the sampling tube 102 into the receiving chamber bottle 105 through a tool to extract the permeated liquid, and then move and descend the alcohol disinfection cotton tube 200 on the rod frame 215 into the receiving chamber bottle 105, and the rotation of the first inner toothed belt 207 drives multiple groups of alcohol disinfection cotton tubes 200 to rotate simultaneously to wipe and disinfect the liquid on the inner wall, without taking out the receiving chamber bottle 105, thereby saving operation steps and time, and improving the permeability detection efficiency of drugs or cosmetics containing oleuropein.

[0053] During use, the artificial membrane 108 is placed on the top of the receiving chamber bottle 105, and the supply chamber bottle 101 is then covered on the top of the artificial membrane 108, and the receiving chamber bottle 105 and the supply chamber bottle 101 are clamped and fixed together by a clip. At this time, the medicine or cosmetic containing oleuropein is inserted into the supply chamber bottle 101 through a tool and evenly smeared on the artificial membrane 108, and then the cover glass 103 is covered on the top of the supply chamber bottle 101. At this time, the heating device located in the diffusion pool 106 is started to heat the water in the diffusion pool 106, so that the artificial membrane 108, the medicine or cosmetic is tested in the diffusion pool 106 at a temperature simulating a human body, and then the medicine or cosmetic penetrates the artificial membrane 108 and drips into the receiving chamber bottle 105 below, and finally the permeability is detected by measuring the amount of liquid in the receiving chamber bottle 105;

[0054] After the test is completed, the supply chamber bottle 101 and the artificial membrane 108 are taken out, and then the slide 222 in the rail frame 202 is moved toward the diffusion pool 106, driving the top frame 210 to move, and then the lifting rod 201, the middle frame 204, etc. can be driven to move. Then, when the moving alcohol disinfection cotton cylinder 200 moves to the position directly above the receiving chamber bottle 105, it stops. At this time, the lifting rod 201 is started to drive the middle frame 204 to move downward, which can drive the support bearing 205 and the alcohol disinfection cotton. The cylinder 200 moves, and then the alcohol disinfection cotton cylinder 200 enters the receiving chamber bottle 105, and then the rotating rod 213 is rotated to drive the large arc plate 212 located at the bottom of the rotating rod 213 to rotate, and then the small arc plate 214 hits the rotating large arc plate 212 and moves toward the end direction close to the track 218, thereby driving the slider 217, the rod frame 215 and the alcohol disinfection cotton cylinder 200 to move, and then the outer wall of the alcohol disinfection cotton cylinder 200 contacts the inner wall of the receiving chamber bottle 105 and stops;

[0055] At this time, the electric push rod 223 is started, and the working end of the electric push rod 223 moves downward to contact and press against the surface of the slider 217, so as to limit the slider 217. Then, the rotating rod 213 is reversed to make the large arc plate 212 separate from the surface of the small arc plate 214, and then the reduction motor 219 is started to drive the gear ring 220 below to rotate, thereby driving the first inner tooth belt 207 to rotate. The second gear 405, the rotating rod 213 and the outer side of the supporting bearing 205 below on the rotating rod 213 are driven by the first inner tooth belt 207 to rotate, and the lower ring 211, the track 218, the rod frame 215 and the alcohol disinfection cotton tube 200 are driven to rotate. The inner wall of the receiving chamber bottle 105 is wiped and disinfected by the rotating alcohol disinfection cotton tube 200. When the wiping and disinfection is completed, the alcohol disinfection cotton tube 200 can be returned to its original position according to the above-mentioned reverse principle.

[0056] Embodiment 3

[0057] Based on Example 2, please refer to Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 and Fig. 9 The rail frame 202 is provided with a driving member, which includes two sets of racks 403 and a second gear 405 fixed to the outer side of the top of the rotating rod 213, the second gear 405 is meshed with the rack 403, and the rail frame 202 is respectively fixed with an L-shaped block 401 and a support block 406, and the L-shaped block 401 is fixed with a hydraulic rod 400, which can drive the two sets of racks 403 to move, and the working end of the hydraulic rod 400 is fixed with a connecting frame 402, and the two ends of the connecting frame 402 are fixedly connected to the rack 403;

[0058] A fixed rail 407 is fixedly provided on the top of the support block 406 , and a sliding rail 404 is fixedly provided on the top of the rack 403 . The stability of the rack 403 during movement can be increased by sliding the sliding rail 404 on the fixed rail 407 , and the end of the sliding rail 404 penetrates into the interior of the fixed rail 407 .

[0059] The present invention has a designed driving member. When the bottom of the alcohol disinfection cotton tube 200 enters the interior of the receiving chamber bottle 105, the hydraulic rod 400 drives the rack 403 to move, thereby driving the rotating rod 213 to rotate. Then, under the action of the large arc plate 212 and the small arc plate 214, the alcohol disinfection cotton tube 200 can be moved toward the inner wall of the receiving chamber bottle 105 and adhered to it. There is no need for personnel to manually rotate the rotating rod 213 to move the alcohol disinfection cotton tube 200, so the operation is convenient.

[0060] During use, when the alcohol disinfection cotton tube 200 enters the receiving chamber bottle 105 and the rotating rod 213 is rotated, the hydraulic rod 400 is started, and the working end of the hydraulic rod 400 drives the connecting frame 402 to move outward, driving the two sets of racks 403 to move, and the racks 403 drive the second gear 405 located on the rotating rod 213 to rotate, thereby driving the rotating rod 213 to rotate, completing the movement of the alcohol disinfection cotton tube 200 toward the inner wall of the receiving chamber bottle 105, without the need for personnel to manually rotate the rotating rod 213.

[0061] Embodiment 4

[0062] Based on Example 3, please refer to Figure 1 , Figure 2 , Figure 3 , Fig.11 , Fig.12 and Fig.13 A limiting member for limiting the slide plate 222 is provided on the rail frame 202, and the limiting member includes a convex column 300 fixed on the surface of the slide plate 222 and a concave plate 301 fixed on the surface of the rail frame 202. A slot is provided inside the convex column 300, and a limiting rod 302 is slidably provided inside the concave plate 301. The bottom of the limiting rod 302 is a spherical structure, which can be inserted into the corresponding slot after contacting the convex column 300. The bottom of the limiting rod 302 can penetrate into the inside of the slot. An upper plate 304 is fixedly provided on the top of the limiting rod 302, and a spring 303 is fixedly provided between the upper plate 304 and the concave plate 301.

[0063] The present invention adopts a designed limiting piece, which can limit the sliding plate 222 when the sliding plate 222 located in the rail frame 202 is moved toward the top of the diffusion pool 106 to drive the alcohol disinfection cotton tube 200 to move to the position directly above the receiving chamber bottle 105, thereby preventing the sliding plate 222 from moving in the rail frame 202 and causing instability during the subsequent wiping and disinfection process of the inner wall of the receiving chamber bottle 105, thereby improving the wiping and disinfection effect of the receiving chamber bottle 105.

[0064] During use, when the slide plate 222 located in the rail frame 202 is moved to the end of the rail frame 202, the boss 300 will also be driven to move, and then the bottom of the limiting rod 302 will hit the boss 300 and move upward, at this time driving the upper plate 304 to move, and then the spring 303 will be stretched, and then the bottom of the limiting rod 302 will be aligned with the slot, and then the bottom of the limiting rod 302 will be inserted into the slot in the boss 300 under the resetting action of the spring 303, completing the limiting of the slide plate 222. At this time, the alcohol disinfection cotton tube 200 is located directly above the receiving chamber bottle 105, limiting the slide plate 222.

[0065] In this embodiment, an artificial membrane 108 is arranged between the receiving chamber bottle 105 and the supply chamber bottle 101, a cover glass 103 is arranged on the top of the supply chamber bottle 101, a sampling tube 102 is arranged on the receiving chamber bottle 105, a plurality of cell racks 107 are fixedly arranged inside the diffusion cell 106, and the receiving chamber bottle 105 is arranged on the cell rack 107.

[0066] Embodiment 5

[0067] Based on Example 4, please refer to Figure 1-Figure 13 The present invention also discloses a detection method of an oleuropein permeability detection device, which specifically comprises the following steps:

[0068] S1, placing the receiving chamber bottle 105, the artificial membrane 108 and the supply chamber bottle 101 into the diffusion cell 106;

[0069] S2, applying the medicine or cosmetic containing oleuropein onto the artificial membrane 108 by means of a tool, and at the same time turning on the heating device in the diffusion pool 106 to heat the water in the diffusion pool 106;

[0070] S3, the medicine or cosmetic sample containing oleuropein on the artificial membrane 108 penetrates the artificial membrane 108 and drips into the receiving chamber bottle 105;

[0071] S4. The liquid dripping into the receiving chamber bottle 105 is taken out by a tool and the amount of the liquid is measured to complete the permeability test of the medicine or cosmetic containing oleuropein.

[0072] The above embodiments are only used to illustrate the technical method of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical method of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical method of the present invention.

Claims

1. An oleuropein permeability detection device, comprising a base (100), a diffusion cell (106) and a plurality of receiving chamber bottles (105), wherein a supply chamber bottle (101) is disposed on the top of the receiving chamber bottle (105), and a transparent plate frame (104) is disposed on the diffusion cell (106), characterized in that: The base (100) is provided with a cleaning mechanism, which comprises: A fixed column (206) and a plurality of rod racks (215), wherein an alcohol disinfection cotton cylinder (200) is arranged outside the rod rack (215) for wiping and disinfecting the inner wall of the receiving chamber bottle (105); A support bearing (205) is sleeved on the outer side of the bottom of the fixed column (206), a first gear (221) is fixedly arranged on the outer side of the top of the support bearing (205), and a first internal toothed belt (207) is meshed on the outside of the first gear (221) for driving multiple groups of first gears (221) to rotate simultaneously.

2. The oleuropein permeability detection device according to claim 1, characterized in that: A rotating rod (213) is rotatably disposed inside the fixed column (206), and a large arc-shaped plate (212) is fixedly disposed at the bottom of the rotating rod (213); A lower ring (211) is fixedly arranged on the outer side of the bottom of the support bearing (205), a track (218) is arranged at the bottom of the lower ring (211), a slider (217) is arranged on the track (218), and a small arc plate (214) is fixedly arranged on the surface of the slider (217).

3. The oleuropein permeability detection device according to claim 2, characterized in that: A through slot is formed at the bottom of the slider (217), the top of the rod frame (215) penetrates into the through slot, and a locking screw (216) is threadedly connected to the inside of the slider (217).

4. The oleuropein permeability detection device according to claim 1, characterized in that: The cleaning mechanism further comprises a top frame (210) and a middle frame (204), and two sets of lifting rods (201) are fixedly arranged on the top frame (210); The support bearing (205) is fixed on the middle frame (204), an L-shaped frame (208) is fixedly arranged on the middle frame (204), a reduction motor (219) is arranged at the end of the L-shaped frame (208), and a gear ring (220) is fixedly arranged at the working end of the reduction motor (219).

5. The oleuropein permeability detection device according to claim 4, characterized in that: Slide plates (222) are fixedly arranged at both ends of the top frame (210), a rail frame (202) is arranged outside the slide plate (222), and a support frame (203) is fixedly arranged between the bottom of the rail frame (202) and the base (100).

6. The oleuropein permeability detection device according to claim 5, characterized in that: The rail frame (202) is provided with a driving member for driving the rotating rod (213) to rotate; The driving member comprises two sets of racks (403) and a second gear (405) fixed to the outer side of the top of the rotating rod (213); an L-shaped block (401) and a support block (406) are fixedly arranged on the rail frame (202), a hydraulic rod (400) is fixedly arranged on the L-shaped block (401), and a connecting frame (402) is fixedly arranged on the working end of the hydraulic rod (400).

7. The oleuropein permeability detection device according to claim 6, characterized in that: A fixed rail (407) is fixedly provided on the top of the support block (406), and a sliding rail (404) is fixedly provided on the top of the rack (403).

8. The oleuropein permeability detection device according to claim 5, characterized in that: The rail frame (202) is provided with a limiting member for limiting the position of the slide plate (222), the limiting member comprising a convex column (300) fixed on the surface of the slide plate (222) and a concave plate (301) fixed on the surface of the rail frame (202), a slot is provided inside the convex column (300), and a limiting rod (302) is slidably provided inside the concave plate (301); An upper plate (304) is fixedly arranged on the top of the limiting rod (302), and a spring (303) is fixedly arranged between the upper plate (304) and the concave plate (301).

9. The oleuropein permeability detection device according to claim 1, characterized in that: An artificial membrane (108) is arranged between the receiving chamber bottle (105) and the supply chamber bottle (101), a sampling tube (102) is arranged on the receiving chamber bottle (105), and a plurality of cell racks (107) are fixedly arranged inside the diffusion cell (106).

10. The detection method of an oleuropein permeability detection device according to any one of claims 1 to 9, characterized in that: The specific steps include: S1, placing the receiving chamber bottle (105), the artificial membrane (108) and the supply chamber bottle (101) into the diffusion cell (106); S2, applying the medicine or cosmetic containing oleuropein onto the artificial membrane (108) by means of a tool, and at the same time turning on the heating device in the diffusion pool (106) to heat the water in the diffusion pool (106); S3, the drug or cosmetic sample containing oleuropein on the artificial membrane (108) permeates the artificial membrane (108) and drips into the receiving chamber bottle (105); S4. The liquid dripping into the receiving chamber bottle (105) is taken out by a tool and the amount of the liquid is measured, thereby completing the permeability test of the medicine or cosmetic containing oleuropein.

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