Immunity improvement feed additive premix and use method thereof

Abstract

The invention relates to the technical field of animal feed, in particular to an immune improvement feed additive premix and a using method thereof.The immune improvement feed additive premix is prepared from, by mass, 28%-30% of codonopsis pilosula, has the effects of tonifying middle-Jiao and Qi and invigorating the spleen and tonifying the lung, and can be used as a feed additive. The obvious effect of improving the immunity of animal bodies is achieved; the astragalus membranaceus is a common qi tonifying medicine in traditional Chinese medicine, and can enhance the immune function of a body and promote healthy growth of animals; the hawthorn fruits have the effects of promoting digestion, relieving stasis, promoting the circulation of qi and dissipating blood stasis, and are beneficial for animals to digest and absorb nutrients; the medicated leaven is beneficial to digestion and spleen and stomach strengthening, and can improve the digestive system function of animals; the traditional Chinese medicine composition has the effects of regulating qi, promoting digestion, eliminating dampness and reducing phlegm, and is also beneficial to conditioning of animal bodies.

Description

Technical Field

[0001] The invention relates to the technical field of animal feed, in particular to an immunity-improving feed additive premix and a use method thereof. Background Art

[0002] At present, the long-term high-dose addition of antibiotics to feed as a medicinal feed additive provides a solid guarantee for the health of farmed animals and has achieved certain results. However, the potential harm caused by long-term high-dose antibiotic addition to farmed animals themselves and the threat to human health through food have attracted more and more attention. In order to better stimulate the growth potential of farmed animals and ensure the sanitation and safety of animal products on the basis of ensuring the healthy growth of farmed animals, seeking green, efficient and safe antibiotic substitutes has become the primary task of animal nutrition circles in various countries. Summary of the invention

[0003] The purpose of the present invention is to overcome the above-mentioned shortcomings, provide an immune-improving feed additive premix for animal breeding, and replace antibiotic drug additives to regulate the specific immunity and nonspecific immunity of farmed animals, improve their resistance to diseases, ensure the health of farmed animals and maximize their growth potential.

[0004] In order to achieve the above purpose, the technical solutions provided are as follows:

[0005] An immunity-improving feed additive premix, characterized in that the immunity-improving feed additive premix is ​​composed of the following Chinese herbal medicine ingredients in specific proportions: 28% to 30% (mass percentage) of Codonopsis pilosula, which has the effects of tonifying the middle and replenishing qi, strengthening the spleen and lungs, and has a significant effect on improving the immunity of the animal body; 28% to 30% (mass percentage) of Astragalus membranaceus, which is a commonly used qi-invigorating medicine in traditional Chinese medicine, can enhance the body's immune function and promote the healthy growth of animals; 14% to 15% (mass percentage) of Hawthorn, which has the effects of digesting food and removing accumulation, promoting qi and dispersing blood stasis, and is helpful for animals to digest and absorb nutrients; 14% to 15% (mass percentage) of Shenqu, which is helpful for digestion and strengthening the spleen and stomach, and can improve the digestive system function of animals; 14% to 15% (mass percentage) of Orange Peel, which has the effects of regulating qi and digesting food, drying dampness and removing phlegm, and is also beneficial to the conditioning of the animal body.

[0006] An immune-improving feed additive premix, characterized in that the immune-improving feed additive premix is ​​composed of the following Chinese herbal medicine ingredients in specific proportions: 29% (mass percentage) of Codonopsis pilosula, 29% (mass percentage) of Astragalus membranaceus, 14% (mass percentage) of Crataegus pinnatifida, 14% (mass percentage) of Shenqu, and 14% (mass percentage) of Orange Peel.

[0007] A method for using the immune-improving feed additive premix as described in claims 1 to 5, characterized in that the immune-improving feed additive premix is ​​added in an amount of 0.5%-2% in the feed.

[0008] The beneficial effects of the present invention are:

[0009] 1. Regulate immunity. Through the combined effect of Chinese herbal medicine, it can regulate the immunity of animals and improve disease resistance.

[0010] 2. Improve production performance. Chinese herbal ingredients can stimulate the growth potential of animals and improve production performance.

[0011] 3. Replace antibiotics: effectively replace antibiotics and avoid toxic side effects such as drug resistance, drug tolerance and residue caused by long-term use of antibiotics.

[0012] 4. Sustainable development: It is conducive to the sustainable development of the breeding and feed industries and is in line with the modern green breeding concept.

[0013] 5. Qiangqiangsan immune-improved feed additive premix provides comprehensive nutritional support and immune regulation functions for animals through the scientific combination of Chinese herbal ingredients. Its use is simple and convenient, and the mixing ratio can be adjusted according to the actual needs of the animals. Compared with traditional antibiotic feed additives, this premix has significant advantages and broad application prospects. In the future, as the concept of green breeding becomes more popular, Qiangqiangsan immune-improved feed additive premix is ​​expected to become one of the important choices for the breeding industry.

[0014] Instruction Manual

[0015] Figure 1 The feeding environment of yaks and the feces characteristics of each group in the embodiment of the present invention; wherein K is a blank control group, D is a group fed with 0.5% of Qiangqiangsan immune improved feed additive premix, Z is a group fed with 1% of Qiangqiangsan immune improved feed additive premix, and G is a group fed with 2% of Qiangqiangsan immune improved feed additive premix;

[0016] Figure 2 These are the results of yak serum immune-related factor detection in the embodiments of the present invention; wherein K is a blank control group, D is a group fed with 0.5% of Qiangqiangsan immune-improving feed additive premix, Z is a group fed with 1% of Qiangqiangsan immune-improving feed additive premix, and G is a group fed with 2% of Qiangqiangsan immune-improving feed additive premix. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] Example

[0019] Feeding method: This experiment was conducted under the same lighting and ventilation conditions. Yaks were fed in a free-range feeding mode. The pre-test period was 10 days and the main test period was 90 days. 32 healthy and disease-free yaks weighing about 200 kg with similar birth dates were selected and randomly divided into 4 groups, with 8 yaks in each group. According to the fattening yaks of about 200 kg, the dosage of the drug additive was calculated as 0.5%, 1%, and 2% of the concentrate in the feed of each yak per day. The above Chinese medicines were crushed and mixed into the concentrate according to the proportion. One control group was fed only the basic diet without adding preparations (K); one yak experimental group added Qiangqiangsan (D) at 0.5% of the concentrate; one yak experimental group added Qiangqiangsan (Z) at 1% of the concentrate; and one yak experimental group added Qiangqiangsan (G) at 2% of the concentrate. Feeding (mixing Chinese herbal compound and concentrate) was done twice a day at 8:30 am and 5:30 pm. 1 / 4 of the test amount was added on the 1st to 2nd day, 1 / 3 of the test amount was added on the 3rd to 4th day, 2 / 3 of the test amount was added on the 5th to 6th day, and the test amount was added on the 7th day. The fish were allowed to drink water freely during the experiment to ensure that each group was fed the same way.

[0020] Observation of each group of yaks:

[0021] By observing the feces and coat of the yaks in the experimental group, the feces characteristics and the smoothness of the yak coat were observed and visually evaluated. At the beginning of feeding, the feces and coat of the yaks in each group were roughly the same. The feces were brown and sticky, and there was a lot of undigested concentrate; the fur was slightly messy, and the yak skin was mixed with a lot of unshed hair. Figure 1 As shown in the figure, the feces of the blank control group were brown and sticky and mixed with a lot of undigested concentrate, and the hair was messy and curly. After feeding the Qiangqiangsan immune improved feed additive premix, compared with the blank group, the feces characteristics of the yaks fed with different doses of Qiangqiangsan immune improved feed additive premix improved, most of them were black and curly, and the concentrate content in the feces was significantly reduced compared with the blank group; the yaks fed with different doses of Qiangqiangsan immune improved feed additive premix had smooth and delicate hair, and the hair fell off in time, and the overall effect was obvious.

[0022] Statistics of growth performance of yaks in each group:

[0023] At the beginning of the experiment (0d), the yaks in each experimental group were weighed on an empty stomach, and the weight was recorded as the initial weight of the experiment. After the 45th and 90th days of the experiment, the yaks were weighed in the same way. The feeding amount of each experimental group was recorded during the experiment. The production performance indicators of average daily feed intake, average daily weight gain, and feed-to-weight ratio were determined by conventional methods.

[0024] Average daily weight gain = (average weight at the end of the test - average weight at the beginning) / number of days of the test;

[0025] Average daily feed intake = total feed consumption during the test period / number of test days;

[0026] Feed-to-weight ratio = average daily feed intake / daily weight gain.

[0027] Table 1 Feed-to-weight ratio of each group of yaks during the trial

[0028]

[0029]

[0030] According to the data in the table above, the average daily weight gain of the experimental group of yaks increased, while their feed-to-weight ratio decreased significantly. This change shows that the digestion and absorption capacity of the experimental group of yaks for concentrated feed has been significantly improved. These changes verify the expected effect of the experiment, that is, enhancing the utilization rate and digestion and absorption capacity of yaks for concentrated feed.

[0031] Blood physiological index detection:

[0032] At the beginning of the experiment (0d), blood samples were collected from yaks in each experimental group and sent to the nearest hospital for blood physiological index detection; at the end of the experiment, blood physiological index detection was performed on yaks in each group. Blood was collected from the jugular vein of the fasting experimental yaks on the morning of the 0th day and the second day after the 90th day of the experiment, and anticoagulation was used for routine blood analysis. Through the detection of yak blood physiological indexes, compared with the control group, the number of red blood cells, white blood cells and lymphocytes in the drug administration group increased; the number of neutrophils in the drug administration group decreased.

[0033] Table 2 Routine blood test results of yaks in each group

[0034]

[0035]

[0036] Immune function test of yaks in each group:

[0037] Immune-related factors (IgM, IgG, IL-2, TNF-α) were detected in yak serum. Figure 2As shown, compared with the control group, the IgM content in group D was extremely significantly increased, and the IgG and IL-2 contents were significantly increased; the IgM and IL-2 contents in group Z were increased, and the IgG content was significantly increased; the IgM content in group G was increased.

[0038] Compared with the control group, the yaks in the drug-treated group showed a remarkable transformation. The characteristics of their feces changed from loose and disordered to compact and orderly, and the color became healthier and more natural. This significant change directly reflects the efficient operation of the digestive system; the yaks covered with hair are like wearing shiny new clothes, with thicker and smoother hair, showing a significant improvement in physical fitness after drug administration; in terms of feed-to-weight ratio, the yaks in the drug-treated group achieved a breakthrough reduction, and the feed conversion rate increased by nearly 20% compared with the control group. This data is undoubtedly a strong proof of their ability to efficiently utilize feed resources. In-depth exploration of its physiological mechanism, through precise blood physiological index detection and immune-related factor determination, it was found that the immune function of the yaks in the drug-treated group was substantially enhanced, and the activity of immune cells and antibody production ability were significantly improved, which built a solid line of defense for the yaks to resist the invasion of external pathogens. The yaks in the drug-treated group have achieved unprecedented significant results in growth performance, health status and economic benefits. Qiangqiangsan immune-improved feed additive premix has injected new vitality and hope into the development of animal husbandry.

[0039] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. An immune-improving feed additive premix, characterized in that: The immune-improving feed additive premix is ​​composed of the following Chinese herbal medicine ingredients in specific proportions: 28%-30% (mass percentage) of Codonopsis pilosula, 28%-30% (mass percentage) of Astragalus membranaceus, 14%-15% (mass percentage) of Crataegus pinnatifida, 14%-15% (mass percentage) of Shenqu, and 14%-15% (mass percentage) of Orange Peel.

2. The immune-improving feed additive premix according to claim 1, characterized in that: The content of Codonopsis pilosula is 29% (mass percentage).

3. The immune-improving feed additive premix according to claim 1, characterized in that: The astragalus root is 29% (mass percentage).

4. The immune-improving feed additive premix according to claim 1, characterized in that: The hawthorn is 14% (mass percentage).

5. The immune-improving feed additive premix according to claim 1, characterized in that: The divine song is 14% (mass percentage).

6. The immune-improving feed additive premix according to claim 1, characterized in that: The orange peel is 14% (mass percentage).

7. A method for using the immune-improving feed additive premix as claimed in claims 1 to 6, characterized in that: The immune-improving feed additive premix is ​​added in an amount of 0.5%-2% in the feed.

Images