Rat fixing device based on medical instrument biological evaluation

Abstract

The invention discloses a rat fixing device based on medical instrument biological evaluation. The device comprises an operation panel, a fixed cover, a sliding piece and a sliding groove. A rectangular opening is designed in the center of the operation panel base and is specially used for intraperitoneal injection operation of a rat; the rat fixing cover is divided into four sections which are respectively arranged on the operation panel; sliding sheets are arranged on the two sides of the fixed cover; the shape of the sliding sheets spliced pairwise is the same as that of the fixed cover; the lower end of the slip sheet is in contact with the operation panel, and the contact part is provided with a chute. According to the rat restraint device, the restraint problem in the rat tail vein injection and blood sampling process, the subcutaneous implantation process, the intraperitoneal injection process and the limb intramuscular injection process is solved, the size of the restraint device can be effectively adjusted so that rats of different body types can be effectively restrained, it is guaranteed that test operation is conducted smoothly, operation is convenient, and restraint of the rats is stable.

Description

Technical Field

[0001] The invention belongs to the technical field of animal experiments and relates to an adjustable rat restraint device for experiments, in particular to a restraint device which is convenient for blood sampling and injection from the tail vein of rats, intramuscular injection of front and rear limbs, subcutaneous injection of the back and intraperitoneal injection of drugs. Background Art

[0002] The safety, efficacy and toxicological evaluation tests of medical devices must be strictly controlled by quality, and the accuracy of the test results is an important indicator required by the industry. Experimental animals are animals engaged in teaching, scientific research, production and testing, and are widely used in the fields of biomedicine, medical devices, scientific research and teaching. Among them, rats are the most widely involved and most commonly used experimental animals in the biological evaluation standards of medical devices. The effective restraint of rats during the experiment is an important guarantee to ensure the scientificity, accuracy and stability of the experimental results. At present, the size of the commonly used restraint devices in the laboratory cannot be adjusted. For rats of different genders and ages, there are problems such as loose restraint and loose fixation, which is not conducive to the operation of the experiment and seriously affects the accuracy of the test results. Especially in the process of conducting subchronic / subacute systemic toxicity tests, loose restraint will seriously affect the operation of tail vein injection of leaching solution, making it difficult to carry out the drug administration process smoothly; at the same time, the extract will be injected into the tail tissue, resulting in insufficient drug administration, which will ultimately affect the scientificity of the experimental results. In addition, due to the large size and ferocious habits of rats, effective restraint can ensure the safety of experimental technicians.

[0003] In general, rat restraint devices are crucial to the smooth progress of experimental operations, the accuracy of experimental results, and the safety of experimental technicians. Therefore, a good and effective restraint device is an indispensable tool in rat experimental operations.

[0004] At present, some restraint devices on the market still have the following shortcomings: 1) Currently common restraint devices are not adjustable and are difficult to adapt to the restraint of rats of different ages, genders, and body sizes. However, the inability to effectively control the restraint state of the rats during the experiment will affect the experimental operation process and reduce the accuracy of the experimental results. 2) Common restraint devices have an opening at the rear with a small caliber, making it difficult for larger rats to enter the restraint device, and the rear opening is too large to effectively fix the experimental rats. 3) Some restraint devices are designed with openings at only two ends of the fixing cover, which severely limits the toxicological evaluation of dosing on the back and abdomen. Summary of the invention

[0005] Since rats are one of the species suitable for safety, efficacy, and toxicology experimental projects in the biological evaluation system of medical devices, and strict quality control must be followed in daily animal experiments, direct contact with samples or indirect contact through extracts must strictly control the dosage, and stable and effective restraint of animals is an important factor in ensuring accurate dosage. Therefore, the restraint device needs to solve the effective adaptation and fixation of rats of different body shapes, genders, and ages, and ensure the effectiveness of fixation, and solve the problem of unstable restraint of rats during the test. At the same time, the present invention designs multiple openings on the fixing cover and the base of the device to ensure that the restraint device can be applied to a variety of experimental projects. For example, subcutaneous implantation on the back of rats, implantation in the leg muscles, intraperitoneal injection, etc.

[0006] The technical solution of the present invention is as follows.

[0007] A rat restraint device based on biological evaluation of medical equipment comprises an operation panel, a fixed cover, a slide, and a slide groove; a rectangular opening is designed in the center of the base of the operation panel, which is specially used for intraperitoneal injection operations of rats; the rat fixed cover is divided into four sections, which are respectively arranged on the operation panel; slides are arranged on both sides of the fixed cover; the shape of the slides after being spliced ​​together is the same as that of the fixed cover; the lower end of the slide is in contact with the operation panel, and a slide groove is provided on the contact part.

[0008] Furthermore, the fixed cover is a semi-cylindrical structure.

[0009] Further, the fixed cover includes a first fixed cover, a second fixed cover, a third fixed cover and a fourth fixed cover; the first fixed cover, the second fixed cover, the third fixed cover and the fourth fixed cover are respectively arranged on the operation panel.

[0010] Furthermore, a stainless steel wire mesh is installed at the front end of the first fixed cover.

[0011] Furthermore, two slides are respectively arranged between the first fixed cover and the second fixed cover, and between the second fixed cover and the third fixed cover, and the shape of the slides after being assembled in pairs is the same as that of the semi-cylindrical fixed cover; the lower end of the slide contacts the operation panel, and a stabilizing slide groove is arranged at the contact portion;

[0012] A fixed short rod and a long strip hard caliper are respectively arranged on the two opposite sliding sheets.

[0013] Furthermore, the slide is a first slide, a second slide, a third slide and a fourth slide, wherein the first slide and the third slide are arranged between the first fixed cover and the second fixed cover; the second slide and the fourth slide are arranged between the second fixed cover and the third fixed cover.

[0014] Further, the slide groove is a first slide groove, a second slide groove, a third slide groove and a fourth slide groove; the first slide groove is connected to the first slide plate; the second slide groove is connected to the second slide plate; the third slide groove is connected to the third slide plate; the fourth slide groove is connected to the fourth slide plate.

[0015] Furthermore, a slot is designed between the third fixing cover and the fourth fixing cover for inserting a special semicircular card; a positioning hole is preset on the card, which is specially used to fix the rat's tail; a small hole is set at the upper end of the card, and a long screw can be inserted for connection. At the same time, a screw hole is also set at the rear of the upper end of the third fixing cover, so that the semicircular card can be firmly fixed between the third fixing cover and the fourth fixing cover by screws, ensuring the firmness of the restraint.

[0016] Furthermore, observing the device in a top view, the first side opening, the third side opening, the second side opening, and the fourth side opening are respectively located on the right and left sides of the second fixed cover and the right and left sides of the third fixed cover, to facilitate intramuscular injection of the left and right forelimbs and left and right hindlimbs of rats.

[0017] Furthermore, four suction cups are arranged at the bottom of the operation panel, namely a first suction cup, a second suction cup, a third suction cup and a fourth suction cup.

[0018] Compared with the prior art, the advantages of the present invention are:

[0019] The invention solves the problem of restraint during rat tail vein injection and blood sampling, subcutaneous implantation, intraperitoneal injection, and limb muscle injection. The restraint device can effectively adjust the size so that rats of different sizes can be effectively restrained to ensure the smooth progress of the experimental operation. It is easy to operate and can restrain rats stably. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a stereoscopic diagram of a rat restraint device.

[0021] Figure 2 It is a top view of the rat restraint device.

[0022] Figure 3 This is the left view of the rat restraint device.

[0023] Figure 4 This is the right view of the rat restraint device.

[0024] Figure 5 It is a look-up view from bottom to top.

[0025] Figure 6 It is a front view of slide 2 and slide 4.

[0026] Markings in the figure: first fixed cover 1, second fixed cover 2, third fixed cover 3, fourth fixed cover 4, first slide 5, second slide 6, third slide 7, fourth slide 8, first slide slot 9, second slide slot 10, third slide slot 11, fourth slide slot 12, operation panel 13, card 14, rectangular opening 15 of fixed cover, first side opening 16, second side opening 17, first suction cup 18, second suction cup 19, third side opening 20, fourth side opening 21, third suction cup 22, fourth suction cup 23, rectangular opening 24, fixed short rod 25, and long strip hard caliper 26. DETAILED DESCRIPTION

[0027] This embodiment mainly includes two parts: a fixed panel and an operating panel. Suction cups are installed at the four corners of the back to fix the base. A rectangular opening is designed in the center of the base, which is specially used for intraperitoneal injection operations in rats. The rat fixing cover is divided into four sections and fixed on the operating panel respectively. Each section of the fixing cover is a semi-cylindrical structure. The specific design is as follows:

[0028] The front end of the first fixed cover 1 is provided with a stainless steel wire mesh.

[0029] Two slides are respectively arranged between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The shape of these slides after being assembled in pairs is the same as that of the semi-cylindrical fixed cover. The lower end of the slide contacts the operation panel, and a stable slide groove is arranged at the contact part.

[0030] The second fixed cover 2 is designed with a rectangular opening for subcutaneous injection on the back of the rat. At the same time, two rectangular first side openings 16 and third side openings 20 are respectively provided on the left and right sides of the second fixed cover 2 near the base, so that the rat's forelimbs can be extended to facilitate forelimb intramuscular injection and other operations.

[0031] Two rectangular openings are also designed on the left and right sides of the third fixed cover 3 near the base, so that the rat's hind limbs can be extended to facilitate operations such as hind limb intramuscular injection.

[0032] A long hard caliper is provided at the upper end of the second slide 6 and the first slide 5, and the caliper can be opened and closed around one end. A semicircular clamping hole is designed at every 0.5 cm at the lower end of the caliper. A fixed short rod is provided at the upper end of the fourth slide 8 and the third slide 7 for connecting and fixing with the long caliper at the upper end of the right slide.

[0033] A slot is designed between the third fixed cover 3 and the fourth fixed cover 4 for inserting a special semicircular card. A positioning hole is preset on the card, which is specifically used to fix the tail of the rat. A small hole is set on the upper end of the card, and a long screw can be inserted for connection. At the same time, a screw hole is also set at the upper rear part of the third fixed cover 3, so that the semicircular card can be firmly fixed between the third fixed cover 3 and the fourth fixed cover 4 by screws, ensuring the firmness of the restraint.

[0034] The specific structure is as follows:

[0035] like Figure 1 to Figure 6 As shown; it includes an operating panel 13, a fixed cover, a slide, and a slide groove; a rectangular opening 24 is designed in the center of the base of the operating panel 13, which is specially used for intraperitoneal injection operations of rats, and a second rectangular opening 24 is an opening below the device, which is used for intraperitoneal injection; the fixed cover is a semi-cylindrical structure; the rat fixed cover is divided into four sections, and each section is arranged on the operating panel; slides are arranged on both sides of the fixed cover; the shape of the slides after being assembled in pairs is the same as that of the fixed cover; the lower end of the slide contacts the operating panel 13, and a slide groove is arranged at the contacting portion.

[0036] Specifically, the fixed cover includes a first fixed cover 1, a second fixed cover 2, a third fixed cover 3 and a fourth fixed cover 4; the first fixed cover 1, the second fixed cover 2, the third fixed cover 3 and the fourth fixed cover 4 are respectively arranged on the operation panel. The second fixed cover 2 is provided with a fixed cover rectangular opening 15, and the specific first rectangular opening 15 is the upper opening at the front end of the device, which is used for subcutaneous injection of the back. The front end of the first fixed cover 1 is equipped with a stainless steel wire mesh. Two slides are respectively arranged between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3, and the shape of the slides after being assembled in pairs is the same as that of the semi-cylindrical fixed cover; the lower end of the slide contacts the operation panel 13, and a stabilizing slide groove is provided at the contact part; fixed short rods 25 and long strip hard calipers 26 are respectively arranged on the two opposing slides. The slides are the first slide 5, the second slide 6, the third slide 7 and the fourth slide 8, wherein the first slide 5 and the third slide 7 are arranged between the first fixed cover 1 and the second fixed cover 2; the second slide 6 and the fourth slide 8 are arranged between the second fixed cover 2 and the third fixed cover 3. The slide grooves are the first slide groove 9, the second slide groove 10, the third slide groove 11 and the fourth slide groove 12; the first slide groove 9 is connected to the first slide 5; the second slide groove 10 is connected to the second slide 6; the third slide groove 11 is connected to the third slide 7; the fourth slide groove 12 is connected to the fourth slide 8. A slot is designed between the third fixed cover 3 and the fourth fixed cover 4 for inserting a special semicircular card 14; a positioning hole is preset on the card 14, which is specially used to fix the tail of the rat; a small hole is set at the upper end of the card 14, which can be inserted with a long screw for connection. At the same time, a screw hole is also provided at the rear portion of the upper end of the third fixed cover 3 so that the semicircular card can be firmly fixed between the third fixed cover 3 and the fourth fixed cover 4 by screws, thereby ensuring the firmness of the fixing.

[0037] like Figure 3-4 As shown, observing the device in a top view, the first side opening 16, the third side opening 20, the second side opening 17, and the fourth side opening 21 are respectively located on the right and left sides of the second fixed cover 2 and the right and left sides of the third fixed cover 3, to facilitate intramuscular injection of the left and right forelimbs and left and right hindlimbs of rats.

[0038] like Figure 5 As shown, four suction cups are arranged at the bottom of the operation panel 13, namely a first suction cup 18, a second suction cup 19, a third suction cup 22 and a fourth suction cup 23.

[0039] Example 1

[0040] The rat restrainer with adjustable size described in this embodiment comprises: an operation panel, a suction cup, a fixing cover, a slide, a slide groove, a caliper, and a card;

[0041] The base is provided with two groups of slide grooves which are symmetrically arranged in pairs relative to the center line of the long axis of the base, and the slide grooves are parallel to the short axis.

[0042] The suction cups are arranged at the four corners of the base.

[0043] The movable slide is located between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The lower end of the slide matches the slide groove. The slide can move left and right along the slide groove and be fixed up and down. During use, when the slide moves to a suitable position, the caliper at the upper end of the slide can effectively fix the slide.

[0044] The semicircular card is located between the third fixed cover 3 and the fourth fixed cover 4. A semicircular hole is reserved at the lower end of the card, and the rat tail passes through the hole to facilitate the tail vein injection operation.

[0045] A wire mesh is designed in front of the first fixed cover 1 to ensure smooth breathing of the experimental rats while playing a role of restraint.

[0046] The operation method of the rat restrainer tail vein injection of the patented invention is as follows:

[0047] 1. Remove the card and the slide, and put the rat in from the rear end of the fourth fixed cover 4.

[0048] 2. When the rat's head enters the proper position of the first fixed cover 1, move the slide. When the slide moves to a position that can just fix the rat, close the caliper at the upper end of the slide to fix the slide.

[0049] 3. Make the rat's tail extend out of the fourth fixing cover 4, insert the semicircular card between the third fixing cover 3 and the fourth fixing cover 4, and fix the card on the third fixing cover 3 with a nut.

[0050] 4. The tail of the rat can be extended for tail vein injection.

[0051] Example 2

[0052] The movable slide is located between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The lower end of the slide matches the slide groove. The slide can move left and right along the slide groove and be fixed up and down. During use, when the slide moves to a suitable position, the caliper at the upper end of the slide can effectively fix the slide.

[0053] The second fixed cover 2 is designed with a rectangular opening. When the test part on the back of the rat moves to the rectangular opening, the slide is moved to a proper position, and the caliper on the upper end of the slide is closed to fix the slide.

[0054] The semicircular card is located between the third fixing cover 3 and the fourth fixing cover 4, and a semicircular hole is reserved at the lower end of the card. The rat tail passes through the hole to stabilize the rat.

[0055] The operation method of subcutaneous injection of the rat restrainer of the present invention is as follows:

[0056] 1. Remove the card and the slide, and put the rat in from the rear end of the fourth fixed cover 4.

[0057] 2. When the subcutaneous injection site on the back of the rat moves to the rectangular opening of the second fixed cover 2, move the slide. When the slide moves to a position that can just fix the rat, close the caliper on the upper end of the slide to fix the slide.

[0058] 3. Make the rat's tail extend out of the fourth fixing cover 4, insert the semicircular card between the third fixing cover 3 and the fourth fixing cover 4, and fix the card on the third fixing cover 3 with a nut.

[0059] 4. When the rat is effectively restrained, subcutaneous injection can be performed on the rat's back.

[0060] Example 3

[0061] The movable slide is located between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The lower end of the slide matches the slide groove. The slide can move left and right along the slide groove and be fixed up and down. During use, when the slide moves to a suitable position, the caliper at the upper end of the slide can effectively fix the slide.

[0062] Two rectangular openings are designed on the left and right sides of the second fixed cover 2 near the base to facilitate the extension of the rat's forelimbs and operations such as forelimb muscle injection of the rat. Two rectangular openings are also designed on the left and right sides of the third fixed cover 3 near the base to facilitate the extension of the rat's hind limbs and operations such as hind limb muscle injection of the rat.

[0063] The semicircular card is located between the third fixing cover 3 and the fourth fixing cover 4, and a semicircular hole is reserved at the lower end of the card. The rat tail passes through the hole to stabilize the rat.

[0064] The operation method of the patented rat restrainer for forelimb and hindlimb muscle injection is as follows:

[0065] 1. Remove the card and the slide, and put the rat in from the rear end of the fourth fixed cover 4.

[0066] 2. When the rat's forelimbs or hind limbs move to the rectangular openings on the left and right sides of the second fixed cover 2 or the third fixed cover 3 close to the base, move the slide. When the slide moves to a position that can just fix the rat, close the caliper at the upper end of the slide to fix the slide.

[0067] 3. Make the rat's tail extend out of the fourth fixing cover 4, insert the semicircular card between the third fixing cover 3 and the fourth fixing cover 4, and fix the card on the third fixing cover 3 with a nut.

[0068] 4. When the rat is effectively restrained, the forelimbs or hindlimbs of the rat can be pulled out from the rectangular openings on the left and right sides of the second fixing cover 2 or the third fixing cover 3 near the base to perform intramuscular injection of the forelimbs or hindlimbs.

[0069] Example 4

[0070] The movable slide is located between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The lower end of the slide matches the slide groove. The slide can move left and right along the slide groove and be fixed up and down. During use, when the slide moves to a suitable position, the caliper at the upper end of the slide can effectively fix the slide.

[0071] The middle part of the base is designed with a rectangular opening for intraperitoneal injection of rats. When the injection site on the rat's abdomen moves to the appropriate position of the base opening, the slide is moved to a suitable position, and the caliper on the upper end of the slide is closed to fix the slide.

[0072] The semicircular card is located between the third fixing cover 3 and the fourth fixing cover 4, and a semicircular hole is reserved at the lower end of the card. The rat tail passes through the hole to stabilize the rat.

[0073] The operation method of intraperitoneal injection of the rat restrainer of the present invention is as follows:

[0074] 1. Remove the card and the slide, and put the rat in from the rear end of the fourth fixed cover 4.

[0075] 2. When the injection site on the rat's abdomen moves to the appropriate position of the base opening, move the slide to the appropriate position, close the caliper on the upper end of the slide, and fix the slide.

[0076] 3. Make the rat's tail extend out of the fourth fixing cover 4, insert the semicircular card between the third fixing cover 3 and the fourth fixing cover 4, and fix the card on the third fixing cover 3 with a nut.

[0077] 4. When the rat is effectively restrained, turn the restraint device over and perform intraperitoneal injection.

Claims

1. A rat restraint device based on biological evaluation of medical devices, characterized in that: The invention comprises an operation panel (13), a fixed cover, a slide, and a slide groove; a rectangular opening (24) is designed in the center of the base of the operation panel (13), which is specially used for intraperitoneal injection operation of rats; the rat fixed cover is divided into four sections, which are respectively arranged on the operation panel; slides are arranged on both sides of the fixed cover; the shape of the slides after being assembled in pairs is the same as that of the fixed cover; the lower end of the slide contacts the operation panel (13), and a slide groove is arranged on the contact part.

2. A rat restraint device based on medical device biological evaluation according to claim 1, characterized in that: The fixed cover is a semi-cylindrical structure.

3. A rat restraint device based on medical device biological evaluation according to claim 1, characterized in that: The fixed cover comprises a first fixed cover (1), a second fixed cover (2), a third fixed cover (3) and a fourth fixed cover (4); the first fixed cover (1), the second fixed cover (2), the third fixed cover (3) and the fourth fixed cover (4) are respectively arranged on the operation panel; the second fixed cover (2) is provided with a fixed cover rectangular opening (15).

4. A rat restraint device based on medical device biological evaluation according to claim 3, characterized in that: The front end of the first fixed cover (1) is provided with a stainless steel wire mesh.

5. A rat restraint device based on medical device biological evaluation according to claim 3, characterized in that: Two slides are respectively arranged between the first fixed cover (1) and the second fixed cover (2), and between the second fixed cover (2) and the third fixed cover (3), and the shape of the slides after being assembled in pairs is the same as that of the semi-cylindrical fixed cover; the lower end of the slide is in contact with the operation panel (13), and a stabilizing slide groove is provided at the contact portion; A fixed short rod (25) and a long strip-shaped hard caliper (26) are respectively arranged on the two opposing slides.

6. A rat restraint device based on medical device biological evaluation according to claim 5, characterized in that: The slides are a first slide (5), a second slide (6), a third slide (7) and a fourth slide (8), wherein the first slide (5) and the third slide (7) are arranged between the first fixed cover (1) and the second fixed cover (2); and the second slide (6) and the fourth slide (8) are arranged between the second fixed cover (2) and the third fixed cover (3).

7. A rat restraint device based on medical device biological evaluation according to claim 5, characterized in that: The slide grooves are a first slide groove (9), a second slide groove (10), a third slide groove (11) and a fourth slide groove (12); the first slide groove (9) is connected to the first slide plate (5); the second slide groove (10) is connected to the second slide plate (6); the third slide groove (11) is connected to the third slide plate (7); and the fourth slide groove (12) is connected to the fourth slide plate (8).

8. A rat restraint device based on medical device biological evaluation according to claim 5, characterized in that: A slot is designed between the third fixing cover (3) and the fourth fixing cover (4) for inserting a specially made semicircular card (14); a positioning hole is preset on the card (14) for fixing the rat's tail; a small hole is set at the upper end of the card (14); at the same time, a screw hole is also set at the rear of the upper end of the third fixing cover (3), so that the semicircular card can be firmly fixed between the third fixing cover (3) and the fourth fixing cover (4) by screws, thereby ensuring the firmness of the fixation.

9. A rat restraint device based on medical device biological evaluation according to claim 5, characterized in that: The first side opening (16), the third side opening (20), the second side opening (17), and the fourth side opening (21) are respectively located on the right and left sides of the second fixed cover (2) and the right and left sides of the third fixed cover (3), so as to facilitate intramuscular injection of the left and right forelimbs and the left and right hindlimbs of the rat.

10. The rat restraint device based on medical device biological evaluation according to claim 5, characterized in that: Four suction cups are arranged at the bottom of the operation panel (13), namely a first suction cup (18), a second suction cup (19), a third suction cup (22) and a fourth suction cup (23).

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