A composition of galena and its preparation method and application

Abstract

This invention discloses a calamine composition, its preparation method, and its application. The calamine composition uses xanthan gum and sodium polyacrylamide dimethyl taurate as a composite thickener, and cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol and sorbitan stearate as emulsifiers to form an oil-in-water formulation. Practice shows that the calamine composition of this invention can achieve improved overall performance. It can not only stabilize high-content calamine in aqueous emulsion systems, but also can be stored for a long time over a wide temperature range. It can be used to prepare cosmetics that can soothe, calm, and repair damaged skin.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products, specifically to a calamine composition, its preparation method, and its application. Background Technology

[0002] Calamine is a carbonate mineral, primarily containing zinc carbonate. It occurs as a massive aggregate, irregularly shaped, powdery, dull, uneven, porous, and honeycomb-like substance. It is widely used in medicine to treat conjunctivitis, slow-healing ulcers, and eczema. When applied to the skin, it helps soothe, calm, and repair damaged skin. Currently, in the cosmetics industry, calamine is mainly used in water-in-oil emulsions. Water-in-oil emulsions typically involve uniformly dispersing calamine within the emulsion system. However, the stability of emulsions is difficult to control. Unstable emulsion systems, especially during prolonged storage, at low temperatures, or at high temperatures, are prone to separation or water separation, negatively impacting the consumer experience. Summary of the Invention

[0003] The purpose of this invention is to overcome one or more deficiencies in the prior art and provide a new calamine composition that can stabilize a high content of calamine in an aqueous emulsion system and can be stored for a long time over a wide temperature range.

[0004] The present invention also provides a method for preparing the above-mentioned calamine composition and its application in the preparation of cosmetics.

[0005] To achieve the above objectives, one technical solution adopted by the present invention is: a calamine composition, wherein the calamine composition comprises:

[0006] (i) Calamine comprising less than 9.0% by weight of the total weight of the calamine composition;

[0007] (ii) 0.01% to 2.0% by weight of a thickener based on the total weight of the calamine composition, the thickener comprising a complex of xanthan gum and sodium polyacrylamide dimethyl taurate, wherein the mass ratio of xanthan gum to sodium polyacrylamide dimethyl taurate is 1:2-15.

[0008] (iii) An emulsifier comprising, based on 0.1% to 5.0% by weight of the total weight of the calamine composition, the emulsifier comprising cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol and sorbitan stearate, wherein the mass ratio of cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol to sorbitan stearate is 4-10:1; and

[0009] (iv) Water.

[0010] According to some preferred aspects of the invention, the calamine is present in the calamine composition at a concentration of 0.5% to 8.5% by weight relative to the total weight of the calamine composition. In some embodiments of the invention, the calamine is present in the calamine composition at a concentration of 2% to 8% by weight relative to the total weight of the calamine composition. Further, in specific cases, the calamine content relative to the total weight of the calamine composition includes, but is not limited to: 0.5% by weight, 0.6% by weight, 0.7% by weight, 0.8% by weight, 0.9% by weight, 1% by weight, 1.2% by weight, 1.5% by weight, 1.8% by weight, 2% by weight, 2.2% by weight, 2.5% by weight, 2.8% by weight, 3% by weight, 3.3% by weight, 3.5% by weight, 3.8% by weight, and 4% by weight. 4.5 wt%, 5 wt%, 5.5 wt%, 5.8 wt%, 5.9 wt%, 6.0 wt%, 6.2 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.8 wt%, 7.0 wt%, 7.2 wt%, 7.3 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8.0 wt%, 8.2 wt%, 8.4 wt%, 8.5 wt%, etc.

[0011] According to some preferred aspects of the invention, the thickener is present in the calamine composition at a concentration of 0.1% to 1.0% by weight relative to the total weight of the calamine composition. In some embodiments of the invention, the thickener is present in the calamine composition at a concentration of 0.15% to 0.55% by weight relative to the total weight of the calamine composition. Furthermore, in specific cases, the thickener is present in a content relative to the total weight of the calamine composition, including but not limited to: 0.1 wt%, 0.12 wt%, 0.15 wt%, 0.2 wt%, 0.25 wt%, 0.28 wt%, 0.3 wt%, 0.31 wt%, 0.32 wt%, 0.33 wt%, 0.34 wt%, 0.35 wt%, 0.36 wt%, 0.37 wt%, 0.38 wt%, 0.39 wt%, 0.4 wt%, 0.41 wt%, 0.42 wt%, 0.45 wt%, 0.48 wt%, 0.5 wt%, 0.52 wt%, 0.55 wt%, 0.6 wt%, 0.7 wt%, etc.

[0012] According to some preferred aspects of the invention, the emulsifier is present in the calamine composition at a concentration of 1.5% to 4.0% by weight relative to the total weight of the calamine composition. In some embodiments of the invention, the emulsifier is present in the calamine composition at a concentration of 1.8% to 3.5% by weight relative to the total weight of the calamine composition. Further, in specific cases, the emulsifier content relative to the total weight of the calamine composition includes, but is not limited to: 1.5% by weight, 1.6% by weight, 1.7% by weight, 1.8% by weight, 1.9% by weight, 2% by weight, 2.1% by weight, 2.2% by weight, 2.3% by weight, 2.4% by weight, 2.5% by weight, 2.8% by weight, 2.9% by weight, 3% by weight, 3.2% by weight, 3.3% by weight, 3.4% by weight, 3.5% by weight, 3.8% by weight, 4.0% by weight, etc.

[0013] According to some preferred aspects of the present invention, the mass ratio of xanthan gum to sodium polyacrylamide dimethyl taurate is 1:5-8, for example, it can be 1:5.2, 1:5.3, 1:5.4, 1:5.5, 1:5.6, 1:5.7, 1:5.8, 1:5.9, 1:6, 1:6.2, 1:6.4, 1:6.5, 1:6.6, 1:6.7, 1:6.8, 1:6.9, 1:7, etc.

[0014] According to some preferred aspects of the present invention, the mass ratio of cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol to sorbitan stearate is 5-8.5:1, for example, it can be 5.2:1, 5.4:1, 5.5:1, 5.6:1, 5.7:1, 5.8:1, 6:1, 6.2:1, 6.3:1, 6.4:1, 6.5:1, 6.6:1, 6.7:1, 6.8:1, 6.9:1, 7:1, 7.1:1, 7.2:1, 7.5:1, 8:1, etc.

[0015] In some embodiments of the present invention, the average particle size of the calamine is less than or equal to 30 μm.

[0016] According to some preferred aspects of the invention, the mass ratio of the calamine, the thickener, and the emulsifier is 1:0.04-0.2:0.25-0.9, more preferably 1:0.04-0.15:0.25-0.65. According to a specific aspect of the invention, the mass ratio of the calamine, the thickener, and the emulsifier is 1:0.06-0.1:0.5-0.65.

[0017] In some embodiments of the present invention, the calamine composition further comprises one or more combinations selected from polyols, chelating agents, oil and wax components, and skin conditioning agents.

[0018] Further, the polyol comprises one or more combinations selected from glycerin, 1,2-hexanediol, and methylpropanediol. In this invention, the synergistic effect of the polyol, thickener, etc., enables the composition to have moisturizing and other effects. The chelating agent comprises disodium EDTA, which can complex with metal ions introduced into the formulation, reducing the impact of metal ions on the formulation system and having a stabilizing effect. The oil and wax component comprises one or more combinations selected from cetearyl alcohol, ethylhexyl stearate, and methyl polytrimethylsiloxane. Further, the oil and wax component is prepared in a mass ratio of 1:3-5:1.5-2.5. In this invention, the oil and wax component can play a certain stabilizing role, helping to stabilize the stability of the emulsion cosmetic and making it easier to apply and absorb. The skin conditioning agent comprises one or more combinations selected from p-hydroxyacetophenone, ethylhexylglycerin, trehalose, niacinamide, and adenosine.

[0019] In some embodiments of the present invention, the calamine composition comprises an aqueous phase, a thickener, an oil phase, and calamine, wherein the oil phase comprises an emulsifier. Further, the aqueous phase comprises water, glycerol, 1,2-hexanediol, methylpropanediol, a chelating agent, p-hydroxyacetophenone, trehalose, nicotinamide, and adenosine. In some embodiments of the present invention, the water is deionized water.

[0020] Furthermore, the oil phase comprises oil and wax components and an emulsifier. In some embodiments of the present invention, the oil and wax components may be liquid oil and / or solid oil and wax, wherein the liquid oil and wax includes, but is not limited to, ethylhexyl stearate, methyl polytrimethylsiloxane, etc., and the solid oil and wax includes, but is not limited to, cetearyl alcohol.

[0021] According to certain aspects of the present invention, the calamine composition, by weight percentage, comprises: 1% to 5% glycerol, 1% to 3% 1,2-hexanediol, 1% to 3% methylpropanediol, 0.005% to 0.5% chelating agent, 1% to 3% trehalose, 1% to 3% nicotinamide, 0.001% to 0.2% adenosine, 0.05% to 0.5% p-hydroxyacetophenone, 0.02% to 0.2% xanthan gum, and 0.1% to 0.5% xanthan gum. The composition comprises, by adjusting the amount of water, sodium polyacrylamide dimethyl taurate (wt%), cetearyl alcohol (wt%), cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol (wt%), sorbitan stearate (wt%), ethylhexyl stearate (wt%), methyl polytrimethylsiloxane (wt%), ethylhexyl glycerol (wt%), and calamine (wt%), wherein the weight of the calamine composition is 100 wt% by adjusting the amount of water.

[0022] Another technical solution provided by the present invention: a method for preparing the above-mentioned calamine composition, the preparation method comprising: dispersing water-soluble components in water to form an aqueous phase, then adding a thickener to form a first phase; mixing an emulsifier and an oil wax component to form an oil phase as a second phase; adding the second phase to the first phase, homogenizing, and after homogenization, adding calamine and mixing.

[0023] Furthermore, during the preparation of the aqueous phase, after the raw materials in the aqueous phase are mixed evenly, a thickener is slowly added under stirring conditions and heated to 75-80℃.

[0024] Furthermore, the emulsifier and oil wax components are mixed to form an oil phase as the second phase, and heated to 75-80℃; then the second phase is slowly added to the first phase under homogenized conditions; furthermore, the homogenization temperature is 75-80℃, the homogenization speed is 5500-6500rpm, and the homogenization time is 5-10min.

[0025] Furthermore, after homogenization, the temperature is lowered to 40-45℃, then calamine is added, and homogenization continues at a speed of 5500-6500 rpm for 1-5 minutes. After adding calamine and homogenizing, the temperature is lowered to 30-35℃ for degassing to obtain the calamine composition.

[0026] Another technical solution provided by the present invention is the application of the above-mentioned calamine composition in the preparation of cosmetics, wherein the cosmetics are able to soothe, calm and repair damaged skin.

[0027] Due to the application of the above technical solutions, the present invention has the following advantages compared with the prior art: Based on the problems of poor stability, limited calamine addition amount, and poor long-term storage performance of calamine in water-based emulsion systems such as oil-in-water formulations in the prior art, the present invention unexpectedly discovered during a large number of experimental studies that by using xanthan gum and sodium polyacrylamide dimethyl taurate as a composite thickener, and combining it with cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol and sorbitan stearate as emulsifiers, the above-mentioned comprehensive performance can be improved. It can not only stabilize high content of calamine in water-based emulsion systems, but also store it for a long time in a wider temperature range. Attached Figure Description

[0028] Figure 1 These are photographs of the materials taken on the day of the experiments in Example 1 and Comparative Examples 1-3 of the present invention;

[0029] Figure 2 To use a scraper Figure 1 Photograph of the material obtained after scraping out the material in Example 1;

[0030] Figure 3 These are photographs of the materials taken on the day of the experiments in Examples 2-3 and Comparative Examples 4-6 of the present invention;

[0031] Figure 4 To use a scraper Figure 3 Photographs of the materials obtained after scraping out the materials in Comparative Examples 4 and 6.

[0032] Figure 5 These are photographs of the material on the day of the experiments in Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 of the present invention.

[0033] Figure 6 To use a scraper Figure 5 Photographs of the material obtained after scraping out the material in the medium-scale ratio 7-8;

[0034] Figure 7 These are photographs of the material on the day of the experiment for Comparative Examples 9-10 of this invention;

[0035] Figure 8 To use a scraper Figure 7 Photographs of the material obtained after scraping out the material in the comparative example 9-10;

[0036] Figure 9 These are photographs of the material in Embodiment 1 and Comparative Examples 1-3 of the present invention after being placed for 2 weeks;

[0037] Figure 10 These are photographs of the materials in Examples 2-3 and Comparative Examples 4-6 of the present invention after being placed for one week;

[0038] Figure 11 To use a scraper Figure 10 Photographs of the materials obtained after scraping out the materials in comparative examples 4 and 6;

[0039] Figure 12 These are photographs of the materials from Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 of the present invention after being placed for one week.

[0040] Figure 13 To use a scraper Figure 12 Photographs of the material obtained after scraping out the material in the medium-scale ratio 7-8;

[0041] Figure 14 These are photographs of the material from Comparative Examples 9-10 of the present invention after being left to stand for one week.

[0042] Figure 15 These are photographs of the materials from Embodiment 1 and Comparative Examples 1-3 of the present invention after being placed at -18°C for 2 weeks.

[0043] Figure 16 These are photographs of the materials from Examples 2-3 and Comparative Examples 4-6 of the present invention after being placed at -18°C for one week.

[0044] Figure 17 To use a scraper Figure 16 Photographs of the materials obtained after scraping out the materials in Examples 2-3 and Comparative Example 4;

[0045] Figure 18 To use a scraper Figure 16 Photographs of the material obtained after scraping out the material in the comparative examples 5-6;

[0046] Figure 19 Photographs of the materials of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 of the present invention after being placed at -18°C for 1 week;

[0047] Figure 20 To use a scraper Figure 19 Photographs of the material obtained after scraping out the material in the medium-scale ratio 7-8;

[0048] Figure 21 To use a scraper Figure 19 Photograph of the material obtained after scraping out the material in Comparative Example 11;

[0049] Figure 22 These are photographs of the material from Comparative Examples 9-10 of the present invention after being placed at -18°C for one week.

[0050] Figure 23 These are photographs of the materials from Embodiment 1 and Comparative Examples 1-3 of the present invention after being placed at 50°C for 2 weeks.

[0051] Figure 24These are photographs of the materials from Examples 2-3 and Comparative Examples 4-6 after being placed at 50°C for one week.

[0052] Figure 25 To use a scraper Figure 24 Photograph of the material obtained after scraping out the material in Example 3;

[0053] Figure 26 Photographs of the materials of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 of the present invention after being placed at 50°C for 1 week.

[0054] Figure 27 These are separate comparative photographs of the materials of Comparative Examples 7-8 and Comparative Example 11 of the present invention after being placed at 50°C for 1 week.

[0055] Figure 28 These are photographs of the material from Comparative Examples 9-10 of this invention after being placed at 50°C for one week.

[0056] Figure 29 To use a scraper Figure 28 Photographs of the material obtained after scraping out material of proportion 9-10. Detailed Implementation

[0057] The above-mentioned solution will be further described below with reference to specific embodiments; it should be understood that these embodiments are used to illustrate the basic principles, main features and advantages of the present invention, and the present invention is not limited to the scope of the following embodiments; the implementation conditions used in the embodiments can be further adjusted according to specific requirements, and the implementation conditions not specified are usually the conditions in conventional experiments.

[0058] Unless otherwise specified in the following examples, all raw materials are commercially available or prepared by conventional methods in the art.

[0059] Methylpropanediol (isobutanediol), purchased from Kunshan Shenliu Trading Co., Ltd.; adenosine, purchased from Henan Dingxin Pharmaceutical Technology Co., Ltd.; trehalose, purchased from NAGASE VIITA CO.,LTD., brand name TREHALOSE 100; nicotinamide, purchased from DSM, brand name Niacinamide PC; xanthan gum, purchased from CP KELCO, brand name... F XANTHAN GUM; Sodium polyacryloyl dimethyl taurate, purchased from CLARIANT, brand name Aristoflex Silk; Carbomer 980, purchased from Lubrizol, brand name 980; Carbomer 981, purchased from Lubrizol, brand name 981; Ammonium acryloyl dimethyl taurate / VP copolymer, purchased from Shanghai Changyun Industrial Co., Ltd., brand name SY VIS-A90; Sodium polyacrylate, purchased from BASF, brand name... SP; Cetearyl alcohol, purchased from BASF, brand name O; Cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol, purchased from SHARONPERSONAL CARE, brand name EMULPHARMA K10 RSPO MB; Sorbitan stearate, purchased from Shanghai Changyun Industrial Co., Ltd., brand name SY EMU-S001; Polyglycerol-3-methyl glucoside distearate, purchased from EVONIK, brand name Care450MB; Glyceryl stearate / PEG-100 stearate, purchased from Shanghai Changyun Industrial Co., Ltd., brand name SY EMU-A1118; Polyglycerol-3 distearate / glyceryl stearate citrate, purchased from EVONIK, brand name NC MB; Cetearyl oleate / sorbitan oleate, purchased from Shanghai Ronghai Biotechnology Co., Ltd., brand name Olivem 1000; Ethylhexyl stearate, purchased from NFC CORPORATION, brand name NF-Ester EHS; Methyl polytrimethylsiloxane, purchased from SHIN-ETSU CHEMICAL CO.,LTD, brand name TMF-1.5; Calamine, purchased from JUHWAN BIO CELL, brand name JH-Calamine.

[0060] Examples 1-3

[0061] This example provides a calamine composition and its preparation method. The formulation of the calamine composition is shown in Table 1.

[0062] Table 1

[0063]

[0064] The preparation method of this calamine composition includes:

[0065] Mix all components in the aqueous phase to form an aqueous phase, then add a thickener and heat to 75-80℃ to form the first phase;

[0066] Mix all components in the oil phase, heat to 75-80℃ to form the oil phase, and use it as the second phase.

[0067] Add the second phase to the first phase and homogenize at a temperature of 75–80°C, a speed of 6000 rpm, and a time of 10 min. After homogenization, cool the mixture to about 45°C, add calamine, mix, and continue homogenizing at a speed of 6000 rpm for 5 min.

[0068] After homogenization, the temperature is lowered to about 35°C, and after degassing, the material is obtained, which is the calamine composition of the present invention.

[0069] Examples 4-5

[0070] This example provides a calamine composition and its preparation method. The formulation of the calamine composition is shown in Table 2.

[0071] Table 2

[0072]

[0073] The preparation method is the same as in Example 1.

[0074] Comparative Examples 1-3

[0075] This example provides a calamine composition and its preparation method. The formulation of the calamine composition is shown in Table 3.

[0076] Table 3

[0077]

[0078] The preparation method is the same as in Example 1.

[0079] Comparative Examples 4-8

[0080] This example provides a calamine composition and its preparation method. The formulation of the calamine composition is shown in Table 4.

[0081] Table 4

[0082]

[0083]

[0084] The preparation method is the same as in Example 1.

[0085] Comparative Examples 9-11

[0086] This example provides a calamine composition and its preparation method. The formulation of the calamine composition is shown in Table 5.

[0087] Table 5

[0088]

[0089]

[0090] The preparation method is the same as in Example 1.

[0091] Performance testing

[0092] Stability tests were conducted, observing the material conditions on the same day (25℃), after 1 week (25℃), after 2 weeks (25℃), after 1 week (frozen, -18℃), after 2 weeks (frozen, -18℃), after 1 week (50℃), and after 2 weeks (50℃).

[0093] (1) Material stability (25℃) on the day of the experiment in Examples 1 and Comparative Examples 1-3

[0094] For detailed results, please refer to... Figure 1 As shown, it is clearly visible that the material in Example 1 showed no abnormalities, the material in Comparative Example 1 exhibited slight stratification (the bottom was white), and the materials in Comparative Examples 2-3 were essentially normal; Meanwhile, see also... Figure 2 As shown, the material from Example 1 was scraped out using a scraper, and the condition of the material was observed. Figure 2 This indicates that the material in Example 1 has a smooth, particle-free surface, is uniform in size, and does not clump. Figure 2 In the left-hand photo, the material was scraped very thinly, yet no particles were observed, indicating that the material in Example 1 of this invention has excellent stability.

[0095] (2) Material stability (25℃) on the day of the experiment in Examples 2-3 and Comparative Examples 4-6

[0096] For detailed results, please refer to... Figure 3 As shown, it is clearly visible that the materials in Examples 2-3 are normal, while particles are precipitated on the surface of the materials in Comparative Examples 4 and 6, and the material in Comparative Example 5 is normal. Further reference can be made to the photographs of the materials in Comparative Examples 4 and 6 after they were scraped off with a scraper. Figure 4 It can be clearly seen that the scraped material contains a lot of particulate matter, and the particle precipitation is very obvious, indicating that its stability is poor.

[0097] (3) Material stability (25°C) on the day of the experiment for Comparative Examples 7-8, Examples 4-5, and Comparative Example 11.

[0098] For detailed results, please refer to... Figure 5 As shown, particles were precipitated on the surface of the materials in Comparative Examples 7-8, while the materials in Examples 4-5 and Comparative Example 11 showed no abnormalities; for the materials in Comparative Examples 7-8, please refer to the photographs after the materials were scraped off with a scraper. Figure 6 It can be clearly seen that the scraped material contains a lot of particulate matter, and the particle precipitation is very obvious (more obvious in Comparative Example 7), indicating that its stability is poor.

[0099] (4) Stability of the material on the day of the experiment (25℃) in Comparative Examples 9-10

[0100] For detailed results, please refer to... Figure 7 As shown, particles were precipitated on the surface of the materials in Comparative Examples 9-10. Further details can be found in the photographs after the materials were scraped off with a scraper. Figure 8 The scraped material has obvious particles on its surface.

[0101] (5) Stability of the material in Examples 1 and Comparative Examples 1-3 after 2 weeks of storage (25°C)

[0102] For detailed results, please refer to... Figure 9 As shown, it is clearly visible that the material in Example 1 is normal, the material in Comparative Example 1 has water stratification and a large amount of water appears at the top, the material in Comparative Example 2 begins to bleed water and a small amount of water begins to precipitate at the top, the material in Comparative Example 3 also has water stratification and the underwater material begins to clump.

[0103] (6) Material stability of Examples 2-3 and Comparative Examples 4-6 after 1 week of storage (25°C)

[0104] For detailed results, please refer to... Figure 10 As shown, the materials in Examples 2-3 showed no abnormalities, while particles were precipitated on the surface of the materials in Comparative Examples 4 and 6, and the material in Comparative Example 5 showed virtually no abnormalities. Further reference can be made to the photographs of the materials in Comparative Examples 4 and 6 after they were scraped off with a scraper. Figure 11 It can be clearly seen that the scraped material contains a lot of particulate matter, and the particle precipitation is very obvious, indicating that its stability is poor.

[0105] (7) Material stability (25°C) of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 after 1 week of storage.

[0106] For detailed results, please refer to... Figure 12 As shown, particles were precipitated in the materials of Comparative Examples 7-8, while the materials of Examples 4-5 and Comparative Example 11 showed basically no abnormalities. Further details about the materials of Comparative Examples 7-8 can be found in photographs after the material was scraped off with a scraper. Figure 13 Of these, Comparative Example 7 showed a very large amount of particle precipitation, while Comparative Example 8 also showed a small amount of particle precipitation.

[0107] (8) Stability of Comparative Examples 9-10 after 1 week of storage (25℃)

[0108] For detailed results, please refer to... Figure 14 As shown, after the material is scraped out from the bottom with a scraper, obvious particles appear on the surface of the scraped material.

[0109] (9) Stability of the material in Examples 1 and Comparative Examples 1-3 after 2 weeks of storage (frozen at -18°C)

[0110] For detailed results, please refer to... Figure 15 As shown, the material in Example 1 showed no abnormalities, while the material in Comparative Example 1 showed water stratification, a large amount of water at the top, and obvious material clumping. Comparative Example 2 showed basically no abnormalities, while the material in Comparative Example 3 also showed water stratification and severe underwater material clumping.

[0111] (10) Material stability of Examples 2-3 and Comparative Examples 4-6 after 1 week of storage (frozen at -18°C)

[0112] For detailed results, please refer to... Figure 16 As shown, the material surfaces of Examples 2-3 are rough, particles are precipitated on the surface of the materials of Comparative Examples 4 and 6, and the material surface of Comparative Example 5 is rough; further, see the material scraped off by their scrapers, see... Figure 17 and Figure 18 As shown, Figure 17 In Example 2, the material showed obvious pits and coarsening; in Example 3, the material was uneven and coarsening began to appear; in Comparative Example 4, the surface texture was very grainy and a large number of particles appeared. Figure 18 In comparison, the material in Comparative Example 5 was uneven and began to show signs of coarsening, while the material in Comparative Example 6 had a very obvious granular texture and a large amount of granules were exuded.

[0113] (11) Material stability of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 after 1 week of storage (frozen at -18°C)

[0114] For detailed results, please refer to... Figure 19 As shown, the materials in Examples 4-5 are basically normal, while the surfaces of the materials in Comparative Examples 8 and 11 are rough, and particles precipitate on the surface of the material in Comparative Example 7. Further, see the materials scraped off by their scrapers. Figure 20 and Figure 21 As shown, Figure 20 In comparison with the material of Example 1, it can be clearly seen that a large number of particles are precipitated in the material of Comparative Example 7, and the surface of the material of Comparative Example 8 is severely rough. Figure 21 In comparison with the material of Example 1, it can be clearly seen that the coarsening phenomenon of the material of Comparative Example 11 is very serious.

[0115] (12) Stability of Comparative Examples 9-10 after 1 week of storage (frozen at -18°C)

[0116] For detailed results, please refer to... Figure 22 As shown, after the material is scraped out from the bottom with a scraper, particles appear on the surface of the scraped material.

[0117] (13) Stability of the material in Examples 1 and Comparative Examples 1-3 after 2 weeks of storage (50°C)

[0118] For detailed results, please refer to... Figure 23 As shown, the material in Example 1 showed no abnormalities, while the materials in Comparative Examples 1-3 all began to separate into layers and change color.

[0119] (14) Material stability (50°C) of Examples 2-3 and Comparative Examples 4-6 after 1 week of storage.

[0120] For detailed results, please refer to... Figure 24As shown, Example 2 showed no abnormalities, Example 3 showed signs of stratification, Comparative Examples 4 and 6 showed stratification, and Comparative Example 5 showed virtually no abnormalities. The material from Example 3 can be further compared to the material scraped off with a scraper. Figure 25 Obvious color bands can be seen in the material.

[0121] (15) Stability of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 after 1 week of storage (50°C)

[0122] For detailed results, please refer to... Figure 26 As shown, Comparative Examples 7-8 and 11 both produced water stratification, while the materials in Examples 4-5 showed no abnormalities.

[0123] For the materials of Comparative Examples 7-8 and 11, please refer to the separate comparison charts. Figure 27 The water stratification phenomenon is very obvious.

[0124] (16) Stability of Comparative Examples 9-10 after 1 week of storage (50℃)

[0125] For detailed results, please refer to... Figure 28 and 29 As shown in the photo, particles can be clearly seen on the surface of the scraped material after it has been scraped out with a scraper.

[0126] The above embodiments are only for illustrating the technical concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and implement it accordingly. They should not be construed as limiting the scope of protection of the present invention. All equivalent changes or modifications made in accordance with the spirit and essence of the present invention should be covered within the scope of protection of the present invention.

[0127] The endpoints and any values ​​of the ranges disclosed herein are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of the various ranges, the endpoint values ​​of the various ranges and individual point values, and individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed herein.

Claims

1. A calamine composition, characterized in that, The calamine composition comprises: (i) Calamine comprising less than 9.0% by weight of the total weight of the calamine composition; (ii) A thickener comprising 0.01% to 2.0% by weight of the total weight of the calamine composition, wherein the thickener is a complex of xanthan gum and sodium polyacrylamide dimethyl taurate, wherein the mass ratio of xanthan gum to sodium polyacrylamide dimethyl taurate is 1:5-8. (iii) An emulsifier comprising 0.1% to 5.0% by weight of the total weight of the calamine composition, said emulsifier being composed of cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol and sorbitan stearate, wherein the mass ratio of cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol to sorbitan stearate is 4-10:1; and (iv) Water; The calamine composition further comprises an oil and wax component, which includes cetearyl alcohol, ethylhexyl stearate, and methyl polytrimethylsiloxane.

2. The calamine composition according to claim 1, characterized in that, The calamine is present in the calamine composition at a concentration of 0.5% to 8.5% by weight relative to the total weight of the calamine composition; and / or, The thickener is present in the calamine composition at a concentration of 0.1% to 1.0% by weight relative to the total weight of the calamine composition; and / or, The emulsifier is present in the calamine composition at a weight of 1.5% to 4.0% relative to the total weight of the calamine composition.

3. The calamine composition according to claim 2, characterized in that, The calamine is present in the calamine composition at a weight of 2% to 8% relative to the total weight of the calamine composition; and / or, The thickener is present in the calamine composition at a weight percentage of 0.15% to 0.55% relative to the total weight of the calamine composition; and / or, The emulsifier is present in the calamine composition at a weight of 1.8% to 3.5% relative to the total weight of the calamine composition.

4. The calamine composition according to claim 1, characterized in that, The mass ratio of the cetearyl glucoside / sorbitan olive oil ester / cetearyl alcohol to the sorbitan stearate is 5-8.5:

1.

5. The calamine composition according to claim 1, characterized in that, The average particle size of the calamine is less than or equal to 30 μm.

6. The calamine composition according to claim 1, characterized in that, The mass ratio of the calamine, the thickener, and the emulsifier is 1:0.04-0.2:0.25-0.

9.

7. The calamine composition according to claim 6, characterized in that, The mass ratio of the calamine, the thickener, and the emulsifier is 1:0.04-0.15:0.25-0.

65.

8. The calamine composition according to claim 1, characterized in that, The calamine composition further comprises one or more combinations selected from polyols, chelating agents, and skin conditioning agents.

9. The calamine composition according to claim 8, characterized in that, The polyol comprises one or more combinations selected from glycerol, 1,2-hexanediol, and methylpropanediol.

10. The calamine composition according to claim 8, characterized in that, The chelating agent contains disodium EDTA.

11. The calamine composition according to claim 8, characterized in that, The skin conditioning agent comprises one or more combinations selected from p-hydroxyacetophenone, ethylhexylglycerin, trehalose, nicotinamide, and adenosine.

12. The calamine composition according to claim 1, characterized in that, In the oil and wax composition, the mass ratio of cetearyl alcohol, ethylhexyl stearate, and methyl polytrimethylsiloxane is 1:3-5:1.5-2.

5.

13. A method for preparing a calamine composition according to any one of claims 1-12, characterized in that, The preparation method includes: The water-soluble components are dispersed in water to form an aqueous phase, and then a thickener is added to form the first phase. Emulsifiers and oil and wax components are mixed to form an oil phase, which serves as the second phase. Add the second phase to the first phase, homogenize, and then add calamine and mix.

14. The use of any calamine composition according to any one of claims 1-12 in the preparation of cosmetics.

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