Traditional Chinese medicine composition with compound honeysuckle flower heat-clearing and detoxifying effects and preparation method of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition with compound honeysuckle flower heat-clearing and detoxifying effects and a preparation method thereof. The invention provides a traditional Chinese medicine composition with compound honeysuckle flower heat clearing and detoxifying effects. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 22-26 parts of lonicerae flos, 20-24 parts of fructus forsythiae, 20-24 parts of selfheal, 20-24 parts of glossy privet leaves, 18-22 parts of herba violae, 17-21 parts of lalang grass rhizome, 15-19 parts of polygala japonica, 12-16 parts of trichosanthes kirilowii maxim, 8-12 parts of radix achyranthis bidentatae, 5-9 parts of rosemary and 4-6 parts of American ginseng. The traditional Chinese medicine composition has the main effects of clearing away heat and toxic materials and dispelling wind and heat and the auxiliary effects of expelling phlegm to arrest coughing and tonifying qi and nourishing yin, has multiple effects of resisting inflammation, resisting viruses, enhancing immunity and the like, can be used for preventing and treating cold, influenza and novel coronavirus infection, and is excellent in effect.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a traditional Chinese medicine composition with compound honeysuckle flower heat-clearing and detoxifying effects and a preparation method thereof. Background Art

[0002] Both honeysuckle and Chinese honeysuckle are plants of the genus Lonicera in the family Caprifoliaceae, and both have the effect of clearing away heat and detoxifying, but in terms of efficacy and application, honeysuckle is better than Chinese honeysuckle. Honeysuckle has a stronger effect of clearing away heat and detoxifying, and has a good effect on symptoms such as exogenous wind-heat or the initial stage of febrile disease, fever, headache, restlessness, insomnia, coma, red tongue, dry throat and mouth; Chinese honeysuckle has a weaker effect of clearing away heat and detoxifying than honeysuckle, but has the effect of dispersing wind-heat, and is more suitable for symptoms such as exogenous wind-heat or the initial stage of febrile disease, fever, slight aversion to wind and cold, headache, thirst, etc.

[0003] Honeysuckle is the dried flower buds or flowers with initial opening of Loniceramacranthoides Hand.-Mazz., L. hypo-glauca Miq., L. confusa DC. or L. fulvoto-mentosa HsuetS.C.Cheng, which belong to the Caprifoliaceae family. It has the effects of clearing away heat and detoxifying, and evacuating wind-heat. It is used for treating carbuncle, sore throat, erysipelas, dysentery caused by heat toxins, wind-heat cold, and fever caused by febrile diseases. It is a very valuable Chinese herbal medicine. However, in actual application, the dosage of honeysuckle is much higher than that of honeysuckle, which leads to less development and application of Chinese herbal medicine prescriptions related to honeysuckle.

[0004] Therefore, how to make full use of the effect of honeysuckle in dispersing wind-heat, enhance the effect of honeysuckle in clearing heat and detoxifying, and provide more Chinese medicine prescriptions containing honeysuckle are problems that technical personnel in this field urgently need to solve. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition with the efficacy of clearing away heat and detoxifying of compound honeysuckle and a preparation method thereof.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The invention provides a traditional Chinese medicine composition with compound honeysuckle heat-clearing and detoxifying effects. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 22-26 parts of honeysuckle, 20-24 parts of forsythia, 20-24 parts of selfheal, 20-24 parts of privet leaves, 18-22 parts of viola yedoensis, 17-21 parts of cogongrass root, 15-19 parts of cyperus rotundus, 12-16 parts of trichosanthes, 8-12 parts of achyranthes bidentata, 5-9 parts of rosemary and 4-6 parts of American ginseng.

[0008] The present invention also provides a method for preparing the traditional Chinese medicine composition having the effect of clearing away heat and detoxifying, comprising the following steps:

[0009] (1) Mix honeysuckle, forsythia, selfheal, privet leaf, Viola yedoensis, Imperatae rhizome, Glehnia littoralis, Trichosanthes kirilowii, Achyranthes bidentata, rosemary, and American ginseng to obtain material 1;

[0010] (2) mixing the material 1 with water and boiling to obtain a filter residue and a filtrate;

[0011] (3) mixing the filter residue with water, boiling, filtering, and obtaining a decoction;

[0012] (4) combining the filtrate with the decoction, concentrating under reduced pressure and then drying to obtain a Chinese medicine composition with heat-clearing and detoxifying effects.

[0013] Preferably, the mass ratio of the material 1 to water in step (2) is 1:4-6.

[0014] Preferably, the decocting time in step (2) is 150 to 250 minutes.

[0015] Preferably, the mass ratio of the filter residue to water in step (3) is 1:2-4.

[0016] Preferably, the decocting time in step (3) is 80 to 160 minutes.

[0017] Preferably, the extract of step (4) has a relative density of 1.12 to 1.18 when concentrated under reduced pressure to 65°C.

[0018] Preferably, the drying temperature in step (4) is 70-80° C. and the drying time is 2-4 hours.

[0019] The present invention also provides a Chinese medicine granule with heat-clearing and detoxifying effects, which is prepared from the following components in parts by mass: 55 to 65 parts of the Chinese medicine composition with heat-clearing and detoxifying effects or the Chinese medicine composition with heat-clearing and detoxifying effects prepared according to the preparation method, 25 to 35 parts of maltodextrin, and 8 to 12 parts of white sugar powder.

[0020] The present invention also provides a method for preparing the Chinese medicine granules with the effect of clearing away heat and detoxifying, comprising mixing the Chinese medicine composition with the effect of clearing away heat and detoxifying, white sugar powder and maltodextrin, performing wet granulation, drying and granulating to obtain the Chinese medicine granules with the effect of clearing away heat and detoxifying.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] Among the components added in the present invention, honeysuckle is used as the main medicine to clear away heat and detoxify, dissipate wind-heat, and kill bacteria; forsythia is used to clear away heat and detoxify, dissipate swelling and resolve stagnation, and dissipate wind-heat; and herbaceous prunella is used to clear the liver and purge fire, dissipate stagnation and reduce swelling, and has the pharmacological effects of resisting pathogenic microorganisms, lowering blood pressure, and lowering blood sugar.

[0023] Ligustrum lucidum leaves have the effects of clearing heat and cooling blood, detoxifying, promoting diuresis, anti-oxidation, and enhancing immunity; Viola yedoensis clears heat and detoxifies, cools blood and reduces swelling; Imperata root cools blood and stops bleeding, clears heat and promotes fluid production, and promotes diuresis and relieves stranguria, and is used as a ministerial drug.

[0024] Guazi Jin can eliminate phlegm and relieve cough, promote blood circulation and remove blood stasis, detoxify and relieve pain; Guazi Koushi can clear away heat and eliminate phlegm, relieve chest tightness and resolve stagnation, moisten dryness and lubricate the intestines, and serve as an adjuvant.

[0025] Achyranthes bidentata nourishes the liver and kidneys, strengthens the tendons and bones, promotes diuresis and relieves stranguria, and guides blood downward; rosemary invigorates the spleen and stomach, and refreshes the mind; American ginseng replenishes qi and nourishes yin, clears away heat and promotes body fluid, enhances immunity, and strengthens the body's nonspecific antibodies, serving as a guiding drug.

[0026] In the formula of the present invention, honeysuckle contains chlorogenic acid, forsythia contains forsythiaside, and selfheal and Ligustrum lucidum leaves contain ursolic acid. The addition of forsythia, selfheal and Ligustrum lucidum leaves can enhance the heat-clearing and detoxifying effects of honeysuckle, so as to further improve the efficacy of the traditional Chinese medicine composition.

[0027] The prescription of the present invention is mainly used to clear away heat and detoxify, and evacuate wind-heat, and is supplemented by expectorant, cough relieving, qi-invigorating and yin-nourishing. It has multiple effects such as anti-inflammatory, antiviral, and immunity-enhancing. It can be used for the prevention and treatment of colds, influenza, and new coronavirus infections, with excellent results. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0029] Figure 1 This is a statistical chart of binaural weight of mice.

[0030] Figure 2 This is a statistical chart of mouse ear swelling rate. DETAILED DESCRIPTION

[0031] The invention provides a traditional Chinese medicine composition with the effect of clearing away heat and detoxifying of compound honeysuckle, which is prepared from the following components in parts by weight: 22-26 parts of honeysuckle, 20-24 parts of forsythia, 20-24 parts of selfheal, 20-24 parts of privet leaves, 18-22 parts of viola yedoensis, 17-21 parts of cogongrass root, 15-19 parts of cyperus rotundus, 12-16 parts of trichosanthes, 8-12 parts of achyranthes bidentata, 5-9 parts of rosemary, and 4-6 parts of American ginseng; preferably, the composition is prepared from the following components in parts by weight: 23-25 ​​parts of honeysuckle, 21-24 parts of forsythia, 20-24 parts of selfheal, 20-24 parts of glossy privet leaves, 18-22 parts of viola yedoensis, 17-21 parts of cogongrass root, 15-19 parts of cyperus rotundus, 12-16 parts of trichosanthes, 8-12 parts of achyranthes bidentata, 5-9 parts of rosemary, and 4-6 parts of American ginseng. 23 parts, selfheal 21-23 parts, privet leaf 21-23 parts, Viola yedoensis 19-21 parts, Imperata root 18-20 parts, Guazijin 16-18 parts, Trichosanthes 13-15 parts, Achyranthes bidentata 9-11 parts, Rosemary 6-8 parts, American ginseng 5 parts; further preferably, it is prepared from the following components in parts by weight: 24 parts of honeysuckle, 22 parts of forsythia, 22 parts of selfheal, 22 parts of privet leaf, 20 parts of Viola yedoensis, 19 parts of Imperata root, 17 parts of Guazijin, 14 parts of Trichosanthes, 10 parts of Achyranthes bidentata, 7 parts of rosemary, and 5 parts of American ginseng.

[0032] The present invention also provides a method for preparing the traditional Chinese medicine composition having the effect of clearing away heat and detoxifying, comprising the following steps:

[0033] (1) Mix honeysuckle, forsythia, selfheal, privet leaf, Viola yedoensis, Imperatae rhizome, Glehnia littoralis, Trichosanthes kirilowii, Achyranthes bidentata, rosemary, and American ginseng to obtain material 1;

[0034] (2) mixing the material 1 with water and boiling to obtain a filter residue and a filtrate;

[0035] (3) mixing the filter residue with water, boiling, filtering, and obtaining a decoction;

[0036] (4) combining the filtrate with the decoction, concentrating under reduced pressure and then drying to obtain a Chinese medicine composition with heat-clearing and detoxifying effects.

[0037] Preferably, the mass ratio of the material 1 to water in step (2) is 1:4-6; preferably 1:5.

[0038] Preferably, the decocting time in step (2) is 150 to 250 min; preferably 170 to 230 min; more preferably 190 to 210 min; and more preferably 200 min.

[0039] Preferably, the mass ratio of the filter residue to water in step (3) is 1:2 to 4; preferably 1:3.

[0040] Preferably, the decocting time in step (3) is 80 to 160 min; preferably 90 to 150 min; more preferably 100 to 140 min; and more preferably 120 min.

[0041] Preferably, the relative density of the extract when concentrated under reduced pressure to 65°C in step (4) is 1.12 to 1.18; preferably 1.13 to 1.17; more preferably 1.14 to 1.16; and more preferably 1.15.

[0042] Preferably, the drying temperature in step (4) is 70-80°C and the time is 2-4 hours; preferably, the drying temperature is 72-78°C and the time is 3 hours; more preferably, the drying temperature is 74-76°C and the time is 3 hours; more preferably, the drying temperature is 75°C and the time is 3 hours.

[0043] The present invention also provides a Chinese medicine granule with heat-clearing and detoxifying effects, which is prepared from the following components in mass parts: 55-65 parts of the Chinese medicine composition with heat-clearing and detoxifying effects, 25-35 parts of maltodextrin, and 8-12 parts of white sugar powder; preferably, it is prepared from the following components in mass parts: 57-63 parts of the Chinese medicine composition with heat-clearing and detoxifying effects, 27-33 parts of maltodextrin, and 9-11 parts of white sugar powder; further preferably, it is prepared from the following components in mass parts: 59-61 parts of the Chinese medicine composition with heat-clearing and detoxifying effects, 29-31 parts of maltodextrin, and 10 parts of white sugar powder; more preferably, it is prepared from the following components in mass parts: 60 parts of the Chinese medicine composition with heat-clearing and detoxifying effects, 30 parts of maltodextrin, and 10 parts of white sugar powder.

[0044] The present invention also provides a method for preparing the Chinese medicine granules with the effect of clearing away heat and detoxifying, comprising mixing the Chinese medicine composition with the effect of clearing away heat and detoxifying, white sugar powder and maltodextrin, performing wet granulation, drying and granulating to obtain the Chinese medicine granules with the effect of clearing away heat and detoxifying.

[0045] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0046] Example 1

[0047] A method for preparing a Chinese medicine composition having the effect of clearing away heat and detoxifying of compound honeysuckle, the steps are as follows:

[0048] (1) Mix 22 parts of honeysuckle, 20 parts of forsythia, 20 parts of selfheal, 20 parts of glossy privet leaves, 18 parts of viola yedoensis, 17 parts of cyperus rotundus, 15 parts of guazijin, 12 parts of trichosanthes, 8 parts of achyranthes, 5 parts of rosemary, and 4 parts of American ginseng to obtain material 1;

[0049] (2) mixing the material 1 with water in a mass ratio of 1:4 and boiling for 150 minutes to obtain a filter residue and a filtrate;

[0050] (3) mixing the filter residue with water in a mass ratio of 1:2 and boiling for 80 minutes, filtering, and obtaining a decoction;

[0051] (4) The filtrate is combined with the decoction, concentrated under reduced pressure to an extract with a relative density of 1.12 at 65° C., and dried at 70° C. for 2 h to obtain a traditional Chinese medicine composition with heat-clearing and detoxifying effects.

[0052] Example 2

[0053] A method for preparing a Chinese medicine composition having the effect of clearing away heat and detoxifying of compound honeysuckle, the steps are as follows:

[0054] (1) Mix 26 parts of honeysuckle, 24 parts of forsythia, 24 parts of selfheal, 24 parts of glossy privet leaves, 22 parts of viola yedoensis, 21 parts of cyperus rotundus, 19 parts of guazijin, 16 parts of trichosanthes, 12 parts of cyathula, 9 parts of rosemary, and 6 parts of American ginseng to obtain material 1;

[0055] (2) mixing the material 1 with water in a mass ratio of 1:6 and boiling for 250 minutes to obtain a filter residue and a filtrate;

[0056] (3) mixing the filter residue with water in a mass ratio of 1:4 and boiling for 160 minutes, filtering, and obtaining a decoction;

[0057] (4) The filtrate is combined with the decoction, concentrated under reduced pressure to an extract having a relative density of 1.18 at 65° C., and dried at 80° C. for 4 h to obtain a traditional Chinese medicine composition having the effect of clearing away heat and detoxifying.

[0058] Example 3

[0059] A method for preparing a Chinese medicine composition having the effect of clearing away heat and detoxifying of compound honeysuckle, the steps are as follows:

[0060] (1) Mix 24 parts of honeysuckle, 22 parts of forsythia, 22 parts of selfheal, 22 parts of glossy privet leaves, 20 parts of viola yedoensis, 19 parts of cyperus rotundus, 17 parts of guazijin, 14 parts of trichosanthes, 10 parts of cyathula, 7 parts of rosemary, and 5 parts of American ginseng to obtain material 1;

[0061] (2) mixing the material 1 with water in a mass ratio of 1:5 and boiling for 200 minutes to obtain a filter residue and a filtrate;

[0062] (3) mixing the filter residue with water in a mass ratio of 1:3 and boiling for 120 minutes, filtering, and obtaining a decoction;

[0063] (4) The filtrate is combined with the decoction, concentrated under reduced pressure to an extract with a relative density of 1.15 at 65° C., and dried at 75° C. for 3 h to obtain a traditional Chinese medicine composition with heat-clearing and detoxifying effects.

[0064] Example 4

[0065] A method for preparing Chinese medicine granules with heat-clearing and detoxifying effects comprises mixing 55 parts of the Chinese medicine composition with heat-clearing and detoxifying effects prepared in Example 1, 25 parts of maltodextrin, and 8 parts of white sugar powder, performing wet granulation, drying, and granulating to obtain Chinese medicine granules with heat-clearing and detoxifying effects.

[0066] Example 5

[0067] A method for preparing Chinese herbal granules with heat-clearing and detoxifying effects comprises mixing 65 parts of the Chinese herbal composition with heat-clearing and detoxifying effects prepared in Example 2, 35 parts of maltodextrin, and 12 parts of white sugar powder, performing wet granulation, drying, and granulating to obtain Chinese herbal granules with heat-clearing and detoxifying effects.

[0068] Example 6

[0069] A method for preparing Chinese herbal granules with heat-clearing and detoxifying effects comprises mixing 60 parts of the Chinese herbal composition with heat-clearing and detoxifying effects prepared in Example 3, 30 parts of maltodextrin, and 10 parts of white sugar powder, performing wet granulation, drying, and granulating to obtain Chinese herbal granules with heat-clearing and detoxifying effects.

[0070] Experimental Example 1

[0071] The xylene-induced acute ear swelling model in mice was used to evaluate the anti-inflammatory effect of the drug.

[0072] Seventy ICR mice with a body weight range of 27 ± 3 g were selected and randomly divided into 7 groups:

[0073] The Chinese medicine composition obtained in Example 3 was used as the experimental group;

[0074] Control group 1: other methods were the same as those in Example 3, except that no Forsythia suspensa, Prunella vulgaris, or Ligustrum lucidum leaf was added during the preparation of the Chinese medicine composition in Example 3.

[0075] Control group 2: other methods were the same as those in Example 3, except that, in the preparation process of the Chinese medicine composition in Example 3, Fructus Forsythiae, Herba Prunellae, and Fructus Ligustri Lucidi were replaced with equal amounts of Herba Taraxaci, Fructus Gardeniae, and Fructus Ecliptae.

[0076] Control group 3: other methods were the same as those in Example 3, except that, during the preparation of the Chinese medicine composition in Example 3, Flos Lonicerae was replaced with an equal amount of Flos Lonicerae.

[0077] The method of use for the experimental group and control group 1 to control group 3 was: dissolve the drug in warm water and then administer it intragastrically, with a dosage of 30 mg / kg body weight.

[0078] The blank control group and the model group were intragastrically administered with an equal amount of normal saline.

[0079] In the prior art group, aspirin was administered orally at a dosage of 30 mg / kg body weight.

[0080] Each group of mice was given the drug for 7 consecutive days, once a day. 30 minutes after oral administration on the 7th day, 30 μL of the inflammatory agent xylene was evenly applied to the front and back of the right ear of each mouse, except for the blank control group, and the left ear was not treated. 30 minutes after modeling, the mice were killed by cervical dislocation, the ears were cut off along the baseline of the mouse auricle, and a 6 mm diameter puncher was used to punch round ear pieces at the same position on the left and right ears. The weight of the left and right ear pieces was immediately accurately weighed with an analytical balance, and the ear piece swelling inhibition rate was calculated. The results are shown in Table 1.

[0081] Table 1 Mouse ear swelling rate

[0082] Group Left ear weight Right ear weight Swelling rate% Experimental Group 8.2 13.6 65.85％ Control group 1 8.1 17.2 112.35％ Control group 2 7.9 16.1 103.8％ Control group 3 8.2 15.4 87.8％ Blank control group 8.4 8.3 -1.19％ Model Group 7.8 19.5 150％ Existing Technology Group 8.3 16.7 101.2％

[0083] From the contents recorded in Table 1, it can be seen that the swelling rate of the model group is 150%, indicating that the xylene-induced mouse ear swelling model was successfully established. From the data obtained from the experimental group, it can be seen that the Chinese medicine composition provided by the present invention can inhibit the xylene-induced mouse ear swelling, and has a significant anti-inflammatory effect, which is significantly better than the drugs in the prior art group.

[0084] It can be seen from the data of the control group that only by adopting the complete formulation of the present invention can the best anti-inflammatory effect be achieved. If some of the components are discarded or replaced with other components with similar effects, the use effect of the composition will be significantly affected.

[0085] Experimental Example 2

[0086] 1. Patient selection criteria: The influenza diagnostic criteria in the "Guidelines for Clinical Diagnosis and Treatment of Influenza" recommended by the Respiratory Diseases Branch of the Chinese Medical Association in 2002 and the "Guidelines for Clinical Research of New Chinese Medicines" issued by the National Health Commission of the People's Republic of China.

[0087] The diagnostic standards of TCM syndrome differentiation refer to the "Guidelines for Clinical Research on New Chinese Medicines for the Treatment of Colds". Wind-heat syndrome includes: obvious fever, slight aversion to wind, headache, constipation, cough, sticky or yellow phlegm, dry throat, or red, swollen and painful throat, thirst, nasal congestion, yellow and turbid nasal discharge, and red edges and tips of the tongue.

[0088] Inclusion criteria: Those who meet the above diagnostic criteria, have a maximum body temperature not exceeding 41°C, have had the above symptoms for no more than 48 hours, and have not taken other therapeutic drugs.

[0089] Exclusion criteria: patients with severe heart, liver and kidney dysfunction or patients with blood diseases and tumors; pregnant and lactating women, menstruating women; mental patients; patients with poor compliance or serious illness who cannot complete treatment.

[0090] 2. A total of 60 patients were enrolled in this trial, with an average age of 35.3 years old. They were randomly divided into two groups, half male and half female. There was no statistically significant difference in gender, age, disease course, body temperature, etc. between the treatment group and the control drug group, and they were comparable.

[0091] The Chinese medicine granules prepared in Example 6 were used as the treatment group; the dosage was: 15 g each time, twice a day.

[0092] Comparative drug group: Take Compound Yinhua Jiedu Granules according to the instructions.

[0093] 3. During the experiment, the therapeutic effect of the drug shall be evaluated according to the following efficacy judgment criteria. The specific efficacy judgment criteria are as follows:

[0094] (1) Cure: Within 24 hours of treatment, body temperature returns to normal without recurrence; symptoms such as chills, headache, fever, myalgia and general malaise completely disappear, with no subjective symptoms or discomfort; clinical observation score decreases by 95%.

[0095] (2) Marked effect: Within 24 hours of treatment, the body temperature decreases by ≥0.5°C but does not return to normal; symptoms such as chills, headache, fever, myalgia, and general malaise are significantly improved; the clinical observation score is reduced by ≥70%.

[0096] (3) Effective: The body temperature dropped by ≥1.0°C within 24 hours of treatment, but did not return to normal; clinical symptoms and signs improved, and the clinical observation score decreased by ≥30%.

[0097] (4) Ineffective: Within 24 hours of treatment, the body temperature dropped by less than 0.5°C, and after 3 days of treatment, the various symptoms did not improve or worsen, and the reduction rate of the integral value after treatment was less than 30%.

[0098] Table 2 Classification standards and scores

[0099]

[0100] Table 3 Treatment results

[0101]

[0102]

[0103] From the contents recorded in Table 3, it can be seen that the Chinese medicine granules provided by the present invention have a good therapeutic effect on influenza, with a total effective rate of up to 96.7%, and the therapeutic effect is better than the drugs in the prior art.

[0104] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition having the effect of clearing away heat and detoxifying of compound honeysuckle, characterized in that: The invention is prepared from the following components in parts by weight: 22-26 parts of honeysuckle, 20-24 parts of forsythia, 20-24 parts of selfheal, 20-24 parts of privet leaves, 18-22 parts of viola yedoensis, 17-21 parts of imperata rhizome, 15-19 parts of cyperus rotundus, 12-16 parts of trichosanthes, 8-12 parts of achyranthes bidentata, 5-9 parts of rosemary and 4-6 parts of American ginseng.

2. The method for preparing the Chinese medicine composition having the effect of clearing away heat and detoxifying according to claim 1, characterized in that: The steps include: (1) Mix honeysuckle, forsythia, selfheal, privet leaf, Viola yedoensis, Imperatae rhizome, Glehnia littoralis, Trichosanthes kirilowii, Achyranthes bidentata, rosemary, and American ginseng to obtain material 1; (2) mixing the material 1 with water and boiling to obtain a filter residue and a filtrate; (3) mixing the filter residue with water, boiling, filtering, and obtaining a decoction; (4) combining the filtrate with the decoction, concentrating under reduced pressure and then drying to obtain a Chinese medicine composition with heat-clearing and detoxifying effects.

3. The method for preparing the Chinese medicine composition having heat-clearing and detoxifying effects according to claim 2, characterized in that: In step (2), the mass ratio of material 1 to water is 1:4-6.

4. The method for preparing the Chinese medicine composition having the effect of clearing away heat and detoxifying according to claim 2, characterized in that: The decocting time in step (2) is 150 to 250 minutes.

5. The method for preparing the Chinese medicine composition having the effect of clearing away heat and detoxifying according to claim 2, characterized in that: The mass ratio of the filter residue to water in step (3) is 1:2-4.

6. The method for preparing the Chinese medicine composition having the effect of clearing away heat and detoxifying according to claim 2, characterized in that: The decocting time in step (3) is 80 to 160 minutes.

7. The method for preparing the Chinese medicine composition having the effect of clearing away heat and detoxifying according to claim 2, characterized in that: The extract of step (4) having a relative density of 1.12 to 1.18 when concentrated under reduced pressure to 65°C.

8. The method for preparing the Chinese medicine composition having the effect of clearing away heat and detoxifying according to claim 2, characterized in that: The drying temperature in step (4) is 70-80° C. and the drying time is 2-4 hours.

9. A Chinese medicine granule with heat-clearing and detoxifying effects, characterized in that: The composition is prepared from the following components in parts by mass: 55 to 65 parts of the Chinese medicinal composition with heat-clearing and detoxifying effects as claimed in claim 1 or the Chinese medicinal composition with heat-clearing and detoxifying effects prepared by the preparation method according to any one of claims 2 to 8, 25 to 35 parts of maltodextrin, and 8 to 12 parts of white sugar powder.

10. The method for preparing the Chinese medicinal granules with heat-clearing and detoxifying effects according to claim 9, characterized in that: The traditional Chinese medicine composition with the effect of clearing away heat and detoxifying, white sugar powder and maltodextrin are mixed, wet granulated, dried and granulated to obtain the traditional Chinese medicine granules with the effect of clearing away heat and detoxifying.

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