Traditional Chinese medicine composition for treating skin ulceration and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating skin ulceration and application of the traditional Chinese medicine composition. 8 to 12 parts of herba violae; 12 to 15 parts of honeysuckle flower; 8-12 parts of Chinese wolfberry fruits; 8-10 parts of radix scutellariae; 5-8 parts of ginseng; 8-10 parts of radix salviae miltiorrhizae; 5 to 8 parts of dandelion; the tripterygium wilfordii, the herba violae, the scutellaria baicalensis, the salvia miltiorrhiza and the lithospermum erythrorhizon are subjected to ethanol extraction, the ethanol concentration is 75%-85%, and the extraction time is 12 hours. By optimizing a traditional Chinese medicine formula, a continuous and powerful anti-inflammatory effect is achieved, the broad-spectrum antibacterial effect is remarkable, a complex infection environment can be effectively covered, meanwhile, wound healing is accelerated, the durability and the anti-fatigue recovery capacity of skin are improved, and therefore the recurrence risk is reduced; a comprehensive and lasting treatment effect is provided for skin ulceration and related skin diseases.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating skin ulcers and application thereof. Background Art

[0002] Skin ulcers are usually caused by trauma, infection, blood circulation disorders or immune dysfunction and other factors, resulting in local skin tissue defects, often accompanied by symptoms such as redness, swelling, pain, and exudation. To promote the healing of skin ulcers, traditional Chinese medicine often uses Chinese herbal medicine compositions that have the effects of clearing away heat and detoxification, reducing swelling and relieving pain, and promoting blood circulation and removing blood stasis, so as to reduce inflammation, promote tissue regeneration and accelerate wound repair.

[0003] At present, commonly used Chinese medicine compositions include honeysuckle, lithospermum officinale, scutellaria baicalensis, salvia miltiorrhiza and other ingredients. The active ingredients such as quercetin, baicalin and shikonin contained in these herbs have anti-inflammatory and antibacterial effects, and can relieve skin damage by inhibiting the growth of pathogens and reducing local inflammatory reactions. In addition, some Chinese medicine ingredients can promote blood circulation and cell repair, and play a certain role in wound healing.

[0004] Although existing Chinese herbal compositions have certain effects in anti-inflammatory, antibacterial and promoting skin repair, they are obviously insufficient in terms of sustained effect and comprehensiveness; first, the anti-inflammatory effect of these compositions is often difficult to maintain for a long time, resulting in easy recurrence of skin ulcers after initial relief; in addition, the antibacterial effect of existing Chinese herbal compositions is usually only effective against certain specific pathogens and cannot fully cover complex infection environments, limiting its application in ulcers caused by multiple infection inducers; finally, based on wound repair and skin durability, the promoting effect of traditional Chinese herbal compositions is relatively slow, and under repeated stimulation or continuous friction, the skin's durability and anti-fatigue recovery ability are poor, making it difficult to meet the needs of clinical patients with skin ulcers for accelerated healing and reduced recurrence. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition for treating skin ulcers and its application, which solves the problems of the deficiencies of the existing traditional Chinese medicine compositions in terms of anti-inflammatory persistence, antibacterial comprehensiveness, and promoting rapid healing of skin wounds and improving skin durability.

[0006] To achieve the above objectives, the present invention is implemented by the following technical scheme: a Chinese medicine composition for treating skin ulcers, the Chinese medicine composition comprising the following components in parts by weight: Tripterygium wilfordii: 10-15 parts; Viola yedoensis: 8-12 portions; Honeysuckle: 12-15 parts; Wolfberry: 8-12 servings; Scutellaria baicalensis: 8-10 parts; Ginseng: 5-8 portions; Salvia miltiorrhiza: 8-10 portions; Dandelion: 5-8 servings; Lithospermum officinale: 4-6 portions.

[0007] Preferably, the extraction method of medicinal materials is: Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale were extracted with ethanol, the ethanol concentration was 75% to 85%, and the extraction time was 12 hours; Honeysuckle, wolfberry and dandelion were extracted by decoction for 2 hours; After the extraction, the extract is concentrated to obtain a concentrated extract.

[0008] Preferably, the pharmaceutical preparation is in the form of an ointment, comprising: The extracts of various medicinal materials are mixed with an oil matrix, which is beeswax. The extracts and the matrix are fully mixed by uniform stirring until a uniform paste preparation is prepared.

[0009] Preferably, the quality control method of the pharmaceutical preparation comprises: Content determination: HPLC was used to determine the contents of the main active ingredients such as triptolide, flavonoids from Viola philadelphica, quercetin from honeysuckle, and Lycium barbarum polysaccharides; Microbiological testing: ensure that the preparation is free of pathogenic microbial contamination and meets the hygienic standards for drug production; Stability testing: Accelerated aging tests are conducted to verify the stability of the drug under different temperature and humidity conditions.

[0010] Preferably, the drug is used to treat skin ulcers, trauma and inflammatory skin diseases, and specific treatment methods include: Apply topical ointment to the affected area 2 to 3 times a day; The usage cycle is 2 to 4 weeks, and the specific course of treatment is adjusted according to the patient's skin ulcer area, infection severity and individual differences.

[0011] Preferably, the mechanism of action of the drug is: Anti-inflammatory effect: It can reduce the redness, swelling and pain of skin ulcer areas by inhibiting local inflammatory response; Antibacterial effect: It can eliminate pathogenic bacteria in the ulcerated area and avoid secondary infection; Promote skin repair: accelerate the healing process of skin wounds, increase skin regeneration and tissue repair; Enhance immunity: By enhancing local immunity, it improves the skin's defense against external pathogens.

[0012] Preferably, the method for preparing the drug comprises the following steps: Mix the various medicinal materials according to the formula ratio and clean the impurities; Extract the medicinal materials. Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale are extracted with ethanol, while honeysuckle, wolfberry, and dandelion are extracted with water decoction. After the extract is concentrated, it is mixed according to proportion to prepare the pharmaceutical preparation; Conduct quality control testing to ensure the effectiveness and safety of medicines.

[0013] Preferably, the storage conditions of the pharmaceutical preparation are: Drugs should be stored in a cool, dry, well-ventilated environment, and the temperature should be controlled between 10 and 25°C; Avoid exposing the drug to sunlight or high temperature to ensure the stability and shelf life of the drug.

[0014] Preferably, the preparation method of the Chinese medicine composition comprises: Mix all the medicinal materials according to the formula ratio, clean the impurities and dry them; The medicinal materials are subjected to ethanol extraction and water decoction extraction, and the obtained extract is concentrated; Mix the extracts of various medicinal materials in proportion and process them into ointment; Conduct quality control testing to ensure the effectiveness, safety and stability of drug ingredients.

[0015] The present invention also provides an application of a traditional Chinese medicine composition for treating skin ulcers. The traditional Chinese medicine composition is used for treating skin ulcers, trauma and inflammatory skin diseases.

[0016] The present invention provides a Chinese medicine composition for treating skin ulcers and its application. It has the following beneficial effects: 1. The composition of the present invention accelerates the wound healing process by promoting skin cell regeneration and tissue repair, and shows significant advantages in healing speed and quality, especially in reducing wound scabs and improving skin elasticity after healing, thereby shortening the healing period.

[0017] 2. The Chinese medicine composition of the present invention has a significant effect in anti-inflammatory effect, can quickly inhibit the inflammatory response in the skin ulcer area, reduce redness, swelling and pain, and provide a lasting anti-inflammatory effect, effectively prevent the spread of inflammation, and enhance the skin's self-repair ability.

[0018] 3. The present invention shows superior effects in enhancing skin durability and anti-fatigue recovery ability. It can maintain the integrity of the skin under repeated stimulation conditions, reduce cracks and redness, and improve the skin's tolerance, which is suitable for long-term skin protection and repair needs. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a flow chart of the preparation method of the present invention. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the specification of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] Please see attached Figure 1 The embodiment of the present invention provides a traditional Chinese medicine composition for treating skin ulcers, and the traditional Chinese medicine composition comprises the following components in parts by weight: Tripterygium wilfordii: 10-15 parts. The active ingredients in Tripterygium wilfordii, such as triptolide, have good anti-inflammatory effects and can reduce the inflammatory response of skin ulcers by inhibiting the production of cytokines and local immune responses. In addition, the antibacterial effect of Tripterygium wilfordii can also help clear the source of infection and promote the healing of ulcers; Viola yedoensis: 8-12 parts. The main active ingredients of Viola yedoensis include Viola yedoensis flavonoids, which have significant antibacterial, antiviral and anti-inflammatory effects. Viola yedoensis can remove local pathogens and viruses, inhibit bacterial growth, reduce inflammatory reactions, and help reduce bacterial infection in ulcerated areas. In addition, Viola yedoensis has a good blood-activating and blood-stasis-removing effect, which can promote blood circulation and accelerate wound healing. Honeysuckle: 12-15 parts. The active ingredients of honeysuckle, such as quercetin and chlorogenic acid, have powerful anti-inflammatory, antioxidant and antibacterial effects. They can effectively remove toxins from the body, reduce skin inflammation, and inhibit bacteria and reduce swelling in ulcerated areas. Through the effects of clearing away heat and detoxification, antibacterial and anti-inflammatory effects, they can reduce inflammatory reactions and promote the repair and healing of ulcerated areas. Wolfberry: 8-12 servings. Wolfberry is rich in polysaccharides, carotene, vitamin C and other ingredients. These ingredients can not only effectively enhance local immunity and reduce the invasion of external pathogens on the skin, but also promote the regeneration of skin cells. Scutellaria baicalensis: 8-10 parts. The flavonoids in Scutellaria baicalensis have a significant inhibitory effect on skin inflammation, and can reduce symptoms such as redness, swelling, and pain in the ulcerated area. In addition, Scutellaria baicalensis can also promote wound healing by improving blood circulation; Ginseng: 5-8 portions. The main components of ginseng include ginsenosides, which have the functions of regulating the immune system, promoting cell metabolism and repair. Ginseng can not only enhance the body's disease resistance, but also promote wound healing by improving local blood circulation. Especially in the recovery period of skin ulcers, ginseng can effectively promote wound healing and shorten recovery time. Danshen: 8-10 parts. The active ingredients of Danshen include tanshinone compounds, which have significant anti-inflammatory and antibacterial effects. Danshen can help repair skin ulcers by dilating blood vessels, promoting blood circulation, and improving local nutrient supply. Its inhibitory effect on inflammatory reactions can help reduce swelling and pain in the skin ulcer area; Dandelion: 5-8 servings. The various active ingredients in dandelion, such as taraxacin and flavonoids, can effectively inhibit local inflammatory reactions and promote the healing of skin ulcers. The antibacterial effect of dandelion on the skin can also reduce the occurrence of infection and help restore the normal function of the skin. Lithospermum: 4-6 parts. The ingredients such as shikonin and shikonone in lithospermum can effectively inhibit the growth of bacteria and viruses, reduce skin inflammation, and promote skin healing. Lithospermum helps reduce redness, swelling, and pain in skin ulcer areas, especially in the process of repairing skin trauma, lithospermum can promote the repair and regeneration of local tissues.

[0022] Please see attached Figure 1 In a preferred embodiment of the present invention, the method for extracting medicinal materials is: Ethanol extraction was performed on Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale. The ethanol concentration was 75% to 85%, and the extraction time was 12 hours. This concentration range can ensure that ethanol can fully dissolve fat-soluble components without excessively dissolving impurities, thereby ensuring the purity of the extract. This extraction time can ensure that the active ingredients in the medicinal materials can be completely dissolved, while avoiding the dissolution of some unnecessary components caused by excessive extraction. Ethanol extraction not only ensures the extraction quality and purity of the active ingredients, but also improves the effect of treating skin ulcers. Water decoction is used to extract honeysuckle, wolfberry and dandelion for 2 hours. The 2-hour decoction can not only fully extract the effective ingredients, but also avoid the destruction of the ingredients caused by long-term decoction. The water decoction extraction method can efficiently extract water-soluble ingredients, play the role of clearing heat and detoxifying, anti-inflammatory and detumescence, and promote the healing of skin ulcers. After extraction, the extract is concentrated to obtain a concentrated extract. By concentrating the extract, the concentration of the active ingredients of the drug is increased, ensuring the durability and stability of the therapeutic effect and facilitating the use of subsequent preparations.

[0023] Please see attached Figure 1 In a preferred embodiment of the present invention, the pharmaceutical preparation is in the form of an ointment, comprising: The extracts of various medicinal materials are mixed with an oil matrix, which is beeswax. The extracts and the matrix are fully mixed by uniform stirring until a uniform paste preparation is obtained. First, 75% to 85% ethanol extraction is performed on medicinal materials such as Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale according to the formula ratio. After extraction, the extracts are concentrated to enrich the effective ingredients. Among them, beeswax has strong adsorption and softness, and can effectively carry the extracts and form a stable paste. At the same time, beeswax has natural antibacterial and moisturizing effects, which can further enhance the effect of the drug on skin wound repair. The uniform stirring technology ensures the uniform distribution of the drug ingredients in the paste, improves the stability of the drug efficacy, and at the same time enables the ointment to fully cover the wound when used and maintain drug release for a long time. The ointment preparation prepared by this method can improve the anti-inflammatory and antibacterial properties of the drug, prolong the action time, and effectively promote wound healing, providing a convenient and efficient treatment method for patients with skin ulcers.

[0024] Please see attached Figure 1 In a preferred embodiment of the present invention, the quality control method of the pharmaceutical preparation comprises: Content determination: High performance liquid chromatography is used to determine the content of the main active ingredients such as triptolide, violet flavonoids, honeysuckle quercetin, and Lycium barbarum polysaccharides. High performance liquid chromatography can ensure the accurate content of the active ingredients in the drug, thereby ensuring the stability and consistency of the efficacy and avoiding adverse reactions caused by overdose or underdose of the drug; Microbiological testing: Ensure that there is no pathogenic microbial contamination in the preparation and that it complies with the sanitary standards for drug production. In microbiological testing, first take a sample of the drug preparation for culture to observe whether there is the growth of pathogenic microorganisms. At the same time, molecular biological methods, such as PCR technology, can also be used to ensure the safety of the drug by detecting the presence of specific genes of pathogenic microorganisms. By checking whether the test is qualified or not, the source of contamination can be eliminated to ensure that the drug meets the sanitary standards for drug production. Through microbiological testing, drugs can be effectively prevented from being contaminated by pathogenic microorganisms and the safety and hygiene of patient use can be guaranteed; Stability testing: Accelerated aging tests are conducted to verify the stability of drugs under different temperature and humidity conditions. Stability testing can effectively verify the performance of drugs under different storage conditions, ensure that the drugs maintain their efficacy throughout the shelf life, and avoid drug failure or deterioration due to improper storage.

[0025] Please see attached Figure 1 In a preferred embodiment of the present invention, the drug is used to treat skin ulcers, trauma and inflammatory skin diseases, and the specific treatment methods include: Apply topical ointment to the affected area 2 to 3 times a day. Topical ointment can effectively relieve the discomfort symptoms such as redness, swelling, and pain in the ulcerated area. The ingredients in the ointment can penetrate directly into the damaged tissue through transdermal absorption of the skin, playing the role of anti-inflammatory, analgesic, and promoting tissue regeneration. The usage cycle is 2 to 4 weeks. The specific course of treatment is adjusted according to the patient's skin ulcer area, infection severity and individual differences. Reasonable treatment planning can help patients complete treatment within a safe and effective dosage range, helping to reduce recurrence and late complications.

[0026] Please see attached Figure 1 In a preferred embodiment of the present invention, the mechanism of action of the drug is: Anti-inflammatory effect: It can reduce the redness, swelling and pain of skin ulcer areas by inhibiting local inflammatory response; Antibacterial effect: It can eliminate pathogenic bacteria in the ulcerated area and avoid secondary infection; Promote skin repair: accelerate the healing process of skin wounds, increase skin regeneration and tissue repair; Enhance immunity: By enhancing local immunity, the skin's defense against external pathogens is improved; Specifically: by inhibiting inflammation, clearing pathogenic bacteria, accelerating skin regeneration and improving immune defense, the overall cure rate of skin ulcers is improved, the possibility of recurrence is reduced, and patients are provided with a safe and effective treatment method.

[0027] Please see attached Figure 1 In a preferred embodiment of the present invention, the method for preparing the drug comprises the following steps: Mix the medicinal materials according to the formula ratio, clean the impurities, and ensure the accuracy of the medicinal material ratio and the purity of the raw materials through weighing and cleaning, so as to improve the extraction efficiency and final efficacy of the medicine; Extract the medicinal materials. Use ethanol to extract Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale. Use water decoction to extract Honeysuckle, Lycium barbarum, and Taraxacum officinale. Through the combination of ethanol extraction and water decoction extraction, the water-soluble and fat-soluble components in the medicinal materials are fully extracted, which improves the efficacy and comprehensiveness of the drugs. After the extract is concentrated, it is mixed in proportion to prepare the drug preparation. The concentration operation ensures that each dose of the drug preparation contains an accurate amount of active ingredients, improves the stability of the drug, and facilitates the quality control of the preparation and the consistency of the efficacy. Through the mixing of preparations and the diversification of dosage forms, the consistency of the drug ingredients is ensured, and the convenience of taking and the accuracy of dosage for patients are improved; Conduct quality control tests to ensure the effectiveness and safety of drugs. Quality control tests ensure the effectiveness, safety and stability of drugs and provide patients with high-quality therapeutic products.

[0028] Please see attached Figure 1 In a preferred embodiment of the present invention, the storage conditions of the pharmaceutical preparation are: Drugs should be stored in a cool, dry, well-ventilated environment. The temperature should be controlled between 10 and 25°C. A well-ventilated environment can prevent moisture accumulation, thereby preventing the drug from becoming moldy and deteriorating. It also helps prevent the loss of volatile components. At the same time, this temperature can prevent the decomposition of drug components and the deterioration of packaging, ensuring that the drug remains stable and effective within its shelf life. Avoid exposing drugs to sunlight or high temperature environments to ensure the stability and shelf life of the drugs. High temperatures will accelerate the oxidation and decomposition reactions of drugs, resulting in a decrease in their effectiveness. Therefore, the space where drugs are stored should avoid contact with high temperature sources such as heaters and stoves to ensure that the drugs are in a stable low-temperature environment.

[0029] Please see attached Figure 1 In a preferred embodiment of the present invention, the preparation method of the Chinese medicine composition comprises: Mix all the medicinal materials according to the formula ratio, clean the impurities and dry them. Through precise weighing and thorough cleaning, ensure the accuracy and purity of the formula of the medicinal materials, lay a good foundation for the subsequent extraction steps, ensure the purity and safety of the drugs, and dry them at low temperature to effectively remove the moisture of the medicinal materials, avoid mildew and maintain the integrity of the active ingredients, providing the best conditions for the subsequent extraction process; The medicinal materials are subjected to ethanol extraction and water decoction extraction, and the extract is concentrated after being obtained. The concentrated extract can increase the concentration of the active ingredients, improve the efficacy of the drug and facilitate the uniform distribution of the preparation; Mix the extracts of various medicinal materials in proportion and process them into ointments. Through mixing and processing in various dosage forms, the uniformity of drug ingredients and the accuracy of dosage are ensured, which is convenient for patients to take and improves the stability of drugs; Conduct quality control testing to ensure the effectiveness, safety and stability of drug ingredients. Quality testing includes: Content Assay: Use high performance liquid chromatography (HPLC) to detect the content of the main active ingredients to ensure the stability of the dosage of each ingredient and the effectiveness of the drug.

[0030] Microbiological testing: ensure that there is no pathogenic microbial contamination in drug preparations, comply with drug production hygiene standards, and ensure drug safety.

[0031] Stability testing: Accelerated aging tests are conducted to verify the stability of the drug under different temperature and humidity conditions to ensure that the drug maintains its efficacy within its shelf life.

[0032] The present invention also provides an application of a traditional Chinese medicine composition for treating skin ulcers, which includes a composition for treating skin ulcers, trauma and inflammatory skin diseases. The traditional Chinese medicine composition of the present invention has significant effects in the treatment of skin ulcers, trauma and inflammatory skin diseases. The composition has multiple functions of anti-inflammatory, antibacterial, promoting repair and enhancing immunity, so that it can effectively alleviate the symptoms of skin diseases, promote skin healing and recovery, and prevent recurrence. Reasonable application methods ensure the best therapeutic effect of the drug and provide patients with a safe and efficient treatment method.

[0033] In order to better understand the present invention, the above contents are described in detail below in conjunction with specific embodiments.

[0034] Example 1: Treatment of diabetic foot ulcers Recipe Ratio Tripterygium wilfordii: 12 servings Viola yedoensis: 10 servings Honeysuckle: 14 servings Wolfberry: 10 servings Scutellaria baicalensis: 9 parts Ginseng: 6 servings Salvia miltiorrhiza: 9 servings Dandelion: 7 servings Lithospermum officinale: 5 parts Preparation method Raw material preparation: Weigh all the medicinal materials according to the above proportions, wash them and dry them at 40°C.

[0035] Extraction process: Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale were soaked in 75% ethanol for 12 hours, filtered and concentrated; Honeysuckle, Lycium barbarum, and Taraxacum officinale were extracted by decoction for 2 hours, filtered and concentrated.

[0036] Mixing and preparation: Mix the extracts of various medicinal materials in proportion and process them into ointment.

[0037] How to use Apply to affected area twice daily for 4 weeks.

[0038] Efficacy observation After 4 weeks of treatment, more than 85% of patients with diabetic foot ulcers experienced a reduction in ulcer wounds, significantly reduced infection and inflammation, and accelerated healing.

[0039] Example 2: Treatment of chronic varicose ulcers Recipe Ratio Tripterygium wilfordii: 13 servings Viola yedoensis: 8 servings Honeysuckle: 15 servings Wolfberry: 9 servings Scutellaria baicalensis: 8 parts Ginseng: 7 servings Salvia miltiorrhiza: 10 servings Dandelion: 6 servings Lithospermum officinale: 4 portions Preparation method Raw material preparation: All medicinal materials are weighed, cleaned and dried according to the above proportions.

[0040] Extraction process: Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale were extracted with 80% ethanol for 12 hours, and honeysuckle, wolfberry, and dandelion were decocted in water for 2 hours, and the extracts were concentrated respectively.

[0041] Mixing and preparation: Mix the extracts of various medicinal materials in proportion and process them into ointment.

[0042] How to use Apply topical ointment to the ulcer three times daily for three weeks.

[0043] Efficacy observation In the efficacy observation on patients with varicose ulcers, after 3 weeks, more than 90% of the patients had a reduction in ulcer area, improved blood circulation in the surrounding skin, and a reduced recurrence rate.

[0044] Example 3: Treatment of traumatic skin ulcers Recipe Ratio Tripterygium wilfordii: 10 servings Viola yedoensis: 12 servings Honeysuckle: 12 servings Wolfberry: 8 servings Scutellaria baicalensis: 10 parts Ginseng: 5 servings Salvia miltiorrhiza: 8 servings Dandelion: 5 servings Lithospermum officinale: 6 portions Preparation method Raw material preparation: weigh, clean and dry all medicinal materials at low temperature.

[0045] Extraction process: 75% ethanol was used to extract Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza and Lithospermum officinale, and honeysuckle, wolfberry and dandelion were extracted by decoction, and the extracts were concentrated respectively.

[0046] Mixing and preparation: The concentrated extracts are mixed evenly and prepared into an ointment.

[0047] How to use Apply topical ointment to the affected area twice a day.

[0048] Efficacy observation After 2 weeks of treatment, more than 80% of patients with traumatic skin ulcers experienced significant symptom relief, reduced inflammation at the ulcer site, and accelerated healing process.

[0049] Comparative experiment 1: Anti-inflammatory experimental test Experimental purpose: To verify the effect of the Chinese medicine composition of the present invention in inhibiting inflammation.

[0050] Experimental setup Experimental group (the group of the present invention): mice were externally treated with the Chinese medicinal composition of the present invention.

[0051] Control group 1 (traditional Chinese medicine group): using traditional anti-inflammatory Chinese medicine (such as single honeysuckle decoction).

[0052] Control group 2 (Western medicine anti-inflammatory group): conventional Western medicine anti-inflammatory drugs (such as ibuprofen solution) were used.

[0053] Blank group: no treatment was performed and served as negative control.

[0054] Experimental procedures Inflammation induction: Mice were injected with inflammatory agents (such as carrageenan) into the feet to induce local inflammation.

[0055] Drug treatment: After the inflammation was induced, mice in each group were given topical drugs according to the experimental settings. The experimental group used the Chinese medicine composition of the present invention, and the control group 1 and the control group 2 used traditional Chinese medicine and Western medicine, respectively.

[0056] Inflammation measurement: The swelling thickness of the mouse feet was measured after 1, 3, 6, 12, and 24 hours to record the degree of inflammation.

[0057] Data collection: All measurement data were collated to observe the inflammatory change trends of each group of mice.

[0058] The comparative experimental data are shown in Table 1: Table 1. Thickness of swelling in the feet of mice in each group (unit: mm) From the data in Table 1, we can get: The Chinese medicine composition of the present invention is superior to traditional Chinese medicine and Western medicine in terms of anti-inflammatory persistence and overall anti-inflammatory effect. The experimental group achieved near-normal inflammation resolution within 24 hours, while the control group failed to fully recover within the same period. Compared with Western medicine, which has a strong anti-inflammatory effect in the early stage but weakens in effect, the present invention shows a stable and sustained anti-inflammatory effect, highlighting the synergistic advantages of multiple Chinese medicine ingredients.

[0059] Comparative experiment 2: Wound healing test Experimental purpose: To verify the effect of the Chinese medicine composition of the present invention in promoting wound healing.

[0060] Experimental setup Experimental group (the group of the present invention): the ointment of the Chinese medicine composition of the present invention was directly applied to the wound surface of the mice.

[0061] Control group 1 (traditional healing Chinese medicine group): using traditional healing Chinese medicine (such as lithospermum officinale paste alone).

[0062] Control group 2 (Western medicine group): Use conventional healing Western medicine (such as erythromycin ointment).

[0063] Blank group: No treatment was performed and the natural healing effect was observed.

[0064] Experimental procedures Wound preparation: Prepare wounds of uniform size (e.g., 1 cm²) on the back of mice to ensure that the wound conditions of each group of mice are consistent.

[0065] Drug treatment: The wounds of mice in each group were treated with different drugs. The experimental group was smeared with the Chinese medicine composition ointment of the present invention, the control group 1 and the control group 2 were respectively treated with traditional Chinese medicine ointment and western medicine ointment, and the blank group was not treated.

[0066] Data collection: Record the changes of wound surface, including wound surface area, degree of redness and swelling, and scab formation, daily for 14 consecutive days. Take photos and record regularly.

[0067] Wound surface measurement: The wound surface area was measured on the 3rd, 7th, 10th and 14th days, and the healing rate was calculated.

[0068] The comparative experimental data are shown in Table 2: Table 2 Wound healing of mice in each group (wound area unit: mm²) From the data in Table 2, we can get: The wound healing speed and healing quality of the experimental group were better than those of the control groups 1 and 2. The present invention achieved nearly complete healing within 14 days, with thin scabs and no obvious redness and swelling, indicating that the present invention can effectively promote the regeneration and repair of wound tissue.

[0069] Comparative experiment 3: fatigue durability test Experimental purpose: To verify the effect of the Chinese medicine composition of the present invention on skin durability and anti-fatigue recovery.

[0070] Experimental setup Experimental group (the group of the present invention): the Chinese medicinal composition of the present invention was applied to the skin fatigue area of ​​the rabbit ears every day.

[0071] Control group 1 (traditional Chinese medicine group): Use traditional Chinese medicine ointment (such as honeysuckle ointment) and apply it to the fatigue area of ​​the rabbit ear skin every day.

[0072] Control group 2 (Western medicine group): Use conventional repair Western medicine (such as cortisone ointment) and apply it to the fatigued skin area every day.

[0073] Blank group: no treatment was used and served as a natural recovery control.

[0074] Experimental procedures Fatigue injury induction: The rabbit ear skin was subjected to continuous mild friction and stretching to simulate long-term fatigue stimulation for 5 consecutive days.

[0075] Drug treatment: After fatigue treatment every day, each group immediately applied drugs according to the experimental settings. The experimental group used the Chinese medicine composition ointment of the present invention, the control group 1 and the control group 2 used traditional Chinese medicine ointment and Western medicine ointment respectively, and the blank group did not receive any treatment.

[0076] Data collection: Observe and record the skin damage recovery status daily for 10 consecutive days, including the degree of redness and swelling, the number of cracks, and changes in skin gloss.

[0077] Fatigue durability measurement: The skin condition was recorded on the 3rd, 5th, 7th and 10th days to evaluate the skin's anti-fatigue recovery ability.

[0078] The comparative experimental data are shown in Table 3: Table 3 Recovery of rabbit ear skin fatigue in each group (number of cracks, redness and swelling scores) Note: The redness and swelling score ranges from 0 to 3, with 0 representing no redness and swelling and 3 representing severe redness and swelling.

[0079] From the data in Table 3, we can get: Experimental group (group according to the present invention): on the 3rd day, the number of cracks and the degree of redness and swelling were significantly reduced, and after the 5th day, there were basically no cracks and redness and swelling, and the skin condition recovered well, showing excellent anti-fatigue durability.

[0080] Control group 1 (traditional Chinese medicine group): The fatigue recovery speed was slower than that of the experimental group. Redness, swelling and cracks still existed on the 5th day. There were still a few cracks on the 10th day. The durability was average.

[0081] Control group 2 (Western medicine group): The cracks and redness and swelling improved rapidly in the early stage, but the recovery effect gradually weakened from the 7th day, and there were still slight cracks and redness and swelling on the 10th day.

[0082] Blank group: The number of cracks and the degree of redness and swelling recovered slowly, and obvious signs of fatigue damage were still present on the 10th day, indicating that the natural recovery was poor.

[0083] The rabbit ear skin in the experimental group showed strong recovery ability in the anti-fatigue durability test, and the cracks and redness subsided in a short time and remained stable.

[0084] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating skin ulcers, characterized in that: The Chinese medicine composition comprises the following components in parts by weight: Tripterygium wilfordii: 10-15 parts; Viola yedoensis: 8-12 portions; Honeysuckle: 12-15 parts; Wolfberry: 8-12 servings; Scutellaria baicalensis: 8-10 parts; Ginseng: 5-8 portions; Salvia miltiorrhiza: 8-10 portions; Dandelion: 5-8 servings; Lithospermum officinale: 4-6 portions.

2. A Chinese medicine composition for treating skin ulcers according to claim 1, characterized in that: The extraction method of medicinal materials is: Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale were extracted with ethanol, the ethanol concentration was 75% to 85%, and the extraction time was 12 hours; Honeysuckle, wolfberry and dandelion were extracted by decoction for 2 hours; After the extraction, the extract is concentrated to obtain a concentrated extract.

3. A Chinese medicine composition for treating skin ulcers according to claim 1, characterized in that: The drug preparation is in the form of an ointment and includes: The extracts of various medicinal materials are mixed with an oil matrix, which is beeswax. The extracts and the matrix are fully mixed by uniform stirring until a uniform paste preparation is prepared.

4. A Chinese medicine composition for treating skin ulcers according to claim 1, characterized in that: Quality control methods for pharmaceutical preparations include: Content determination: HPLC was used to determine the contents of the main active ingredients such as triptolide, flavonoids from Viola philadelphica, quercetin from honeysuckle, and Lycium barbarum polysaccharides; Microbiological testing: ensure that the preparation is free of pathogenic microbial contamination and meets the hygienic standards for drug production; Stability testing: Accelerated aging tests are conducted to verify the stability of the drug under different temperature and humidity conditions.

5. A Chinese medicine composition for treating skin ulcers according to claim 1, characterized in that: Drugs are used to treat skin ulcers, wounds, and inflammatory skin diseases. Specific treatments include: Apply topical ointment to the affected area 2 to 3 times a day; The usage cycle is 2 to 4 weeks, and the specific course of treatment is adjusted according to the patient's skin ulcer area, infection severity and individual differences.

6. A Chinese medicine composition for treating skin ulcers according to claim 1, characterized in that: The drug's mechanism of action is: Anti-inflammatory effect: It can reduce the redness, swelling and pain of skin ulcer areas by inhibiting local inflammatory response; Antibacterial effect: It can eliminate pathogenic bacteria in the ulcerated area and avoid secondary infection; Promote skin repair: accelerate the healing process of skin wounds, increase skin regeneration and tissue repair; Enhance immunity: By enhancing local immunity, it improves the skin's defense against external pathogens.

7. A Chinese medicine composition for treating skin ulcers according to claim 1, characterized in that: The preparation method of the drug comprises the following steps: Mix the various medicinal materials according to the formula ratio and clean the impurities; Extract the medicinal materials. Tripterygium wilfordii, Viola yedoensis, Scutellaria baicalensis, Salvia miltiorrhiza, and Lithospermum officinale are extracted with ethanol, while honeysuckle, wolfberry, and dandelion are extracted with water decoction. After the extract is concentrated, it is mixed according to proportion to prepare the pharmaceutical preparation; Conduct quality control testing to ensure the effectiveness and safety of medicines.

8. A Chinese medicine composition for treating skin ulcers according to claim 1, characterized in that: The storage conditions of the drug preparations are: Drugs should be stored in a cool, dry, well-ventilated environment, and the temperature should be controlled between 10 and 25°C; Avoid exposing the drug to sunlight or high temperature to ensure the stability and shelf life of the drug.

9. A Chinese medicine composition for treating skin ulcers according to claim 1, characterized in that: The preparation method of the Chinese medicine composition comprises: Mix all the medicinal materials according to the formula ratio, clean the impurities and dry them; The medicinal materials are subjected to ethanol extraction and water decoction extraction, and the obtained extract is concentrated; Mix the extracts of various medicinal materials in proportion and process them into ointment; Conduct quality control testing to ensure the effectiveness, safety and stability of drug ingredients.

10. An application of a Chinese medicine composition for treating skin ulcers, characterized in that: A Chinese medicinal composition for treating skin ulcers according to any one of claims 1 to 9 is used to treat skin ulcers, trauma and inflammatory skin diseases.

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