Anti-infection traditional Chinese medicine granules and therapeutic application thereof in resisting drug-resistant bacteria

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses anti-infection traditional Chinese medicine granules and a therapeutic application thereof in resisting drug-resistant bacteria. Comprising the following raw materials in parts by weight: 0.5-1 part of a snail slime extract, 10-15 parts of a herba houttuyniae extract, 5-10 parts of honey, 8-12 parts of a honeysuckle flower extract, 6-10 parts of a fructus forsythiae extract, 8-12 parts of a radix scutellariae extract, 6-10 parts of a dandelion extract, 5-8 parts of a herba violae extract, 4-6 parts of a wild chrysanthemum flower extract, 5-8 parts of a folium isatidis extract and 4-6 parts of a herba andrographitis extract. And 8-12 parts of a spreading hedyotis herb extract. The snail mucus, the honey, the snake gall, the herba houttuyniae and other components which are not commonly used but have antibacterial and anti-inflammatory effects are added into the traditional Chinese medicine components, so that the components of the traditional Chinese medicine granules are obviously different from those of anti-infection traditional Chinese medicine granules in the prior art, and the traditional Chinese medicine granules can be externally applied to achieve the anti-infection purpose; various traditional Chinese medicines with different characteristics aiming at infection bacteria can be combined for use, so that a synergistic effect is formed, and the drug resistance risk caused by use of a single drug is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and specifically relates to an anti-infective traditional Chinese medicine granule and its therapeutic use against drug-resistant bacteria. Background Art

[0002] The skin is the body's first immune defense line and also the body's first protective barrier. Skin diseases such as scalds and mechanical injuries are often accompanied by redness, swelling, burning pain or blisters at the injured area. During treatment, not only does the wound surface need to be cleaned and disinfected first, but in order to avoid wound infection, anti-infective agents are required. Anti-infective traditional Chinese medicine granules are the product of the combination of traditional Chinese medicine theory and modern pharmaceutical technology. They usually select traditional Chinese medicine materials with the effects of clearing heat and detoxifying, anti-inflammatory and bactericidal, and promoting wound healing, such as Coptis chinensis, honeysuckle, and lithospermum. After processes such as extraction, concentration, and granulation, these traditional Chinese medicine granules can play a multi-target and multi-path antibacterial role in the treatment of wound infection, while promoting wound healing and reducing scar formation. It is an important application of traditional Chinese medicine in the field of wound anti-infection.

[0003] However, for traditional oral anti-infective traditional Chinese medicine granules, their main active ingredients lie in the main traditional Chinese medicine materials, and most of the anti-infective traditional Chinese medicine components on the market contain the traditional Chinese medicine components of this main traditional Chinese medicine material, such as honeysuckle and Coptis chinensis. During the process of pathogen mutation, drug resistance is easily formed, ultimately greatly weakening the anti-infective treatment effect of the anti-infective traditional Chinese medicine granules and being unfavorable for the anti-infection treatment of wounds. Therefore, we propose an anti-infective traditional Chinese medicine granule and its therapeutic use against drug-resistant bacteria. Summary of the Invention

[0004] The purpose of the present invention is to provide an anti-infective traditional Chinese medicine granule and its therapeutic use against drug-resistant bacteria. By adding components such as snail mucus, honey, snake gallbladder, and houttuynia cordata, which are not commonly used but have antibacterial and anti-inflammatory effects, to the traditional Chinese medicine components, the components of the traditional Chinese medicine granule are significantly different from those of the existing anti-infective traditional Chinese medicine granules, and it can be used for external application to achieve its anti-infective purpose. Furthermore, it can combine multiple traditional Chinese medicines with different characteristics for infected bacteria to form a synergistic effect and reduce the risk of drug resistance caused by the use of a single drug, solving the problems proposed in the background art.

[0005] To achieve the above object, the present invention provides the following technical solution: An anti-infective traditional Chinese medicine granule and its therapeutic use against drug-resistant bacteria, the raw materials of which include, by weight ratio: 0.5 - 1 part of snail mucus extract, 10 - 15 parts of houttuynia cordata extract, 5 - 10 parts of honey, 8 - 12 parts of honeysuckle flower extract, 6 - 10 parts of forsythia suspense extract, 8 - 12 parts of scutellaria baicalensis extract, 6 - 10 parts of dandelion extract, 5 - 8 parts of viola philippica extract, 4 - 6 parts of wild chrysanthemum extract, 5 - 8 parts of isatis indigotica extract, 4 - 6 parts of andrographis paniculata extract, 8 - 12 parts of oldenlandia diffusa extract, 4 - 6 parts of lobelia chinensis extract, 2 - 4 parts of liquorice extract.

[0006] As a preferred embodiment of the present invention, it includes 0.5 part of snail mucus extract, 10 parts of houttuynia cordata extract, 5 parts of honey, 8 parts of honeysuckle flower extract, 6 parts of forsythia suspense extract, 8 parts of scutellaria baicalensis extract, 6 parts of dandelion extract, 5 parts of viola philippica extract, 4 parts of wild chrysanthemum extract, 5 parts of isatis indigotica extract, 4 parts of andrographis paniculata extract, 8 parts of oldenlandia diffusa extract, 4 parts of lobelia chinensis extract, 2 parts of liquorice extract.

[0007] As a preferred embodiment of the present invention, it includes 0.7 part of snail mucus extract, 12 parts of houttuynia cordata extract, 7 parts of honey, 9 parts of honeysuckle flower extract, 7 parts of forsythia suspense extract, 9 parts of scutellaria baicalensis extract, 7 parts of dandelion extract, 6 parts of viola philippica extract, 4.5 parts of wild chrysanthemum extract, 6 parts of isatis indigotica extract, 4.5 parts of andrographis paniculata extract, 9 parts of oldenlandia diffusa extract, 4.5 parts of lobelia chinensis extract, 3 parts of liquorice extract.

[0008] As a preferred embodiment of the present invention, it includes 0.9 part of snail mucus extract, 13 parts of houttuynia cordata extract, 8 parts of honey, 10 parts of honeysuckle flower extract, 8 parts of forsythia suspense extract, 10 parts of scutellaria baicalensis extract, 8 parts of dandelion extract, 7 parts of viola philippica extract, 5 parts of wild chrysanthemum extract, 7 parts of isatis indigotica extract, 5 parts of andrographis paniculata extract, 10 parts of oldenlandia diffusa extract, 5 parts of lobelia chinensis extract, 3.5 parts of liquorice extract.

[0009] As a preferred embodiment of the present invention, it includes 1 part of snail mucus extract, 14 parts of houttuynia cordata extract, 9 parts of honey, 11 parts of honeysuckle flower extract, 9 parts of forsythia suspense extract, 11 parts of scutellaria baicalensis extract, 9 parts of dandelion extract, 7.5 parts of viola philippica extract, 5.5 parts of wild chrysanthemum extract, 7.5 parts of isatis indigotica extract, 5.5 parts of andrographis paniculata extract, 11 parts of oldenlandia diffusa extract, 5.5 parts of lobelia chinensis extract, 4 parts of liquorice extract.

[0010] As a preferred embodiment of the present invention, there is 1 part of snail mucus extract, 15 parts of houttuynia cordata extract, 10 parts of honey, 12 parts of honeysuckle extract, 10 parts of forsythia suspensa extract, 12 parts of scutellaria baicalensis extract, 10 parts of dandelion extract, 8 parts of viola yedoensis extract, 6 parts of wild chrysanthemum extract, 8 parts of isatis indigotica extract, 6 parts of andrographis paniculata extract, 12 parts of oldenlandia diffusa extract, 6 parts of lobelia chinensis extract, and 4 parts of licorice extract.

[0011] As a preferred embodiment of the present invention, the use of the anti-infective traditional Chinese medicine granules in the preparation of a medicament for treating drug-resistant bacteria.

[0012] As a preferred embodiment of the present invention, the anti-infective traditional Chinese medicine granules can be used for oral administration or external application.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0014] 1. By adding components such as snail mucus, honey, snake gallbladder, and houttuynia cordata, which are not commonly used but have antibacterial and anti-inflammatory effects, to the traditional Chinese medicine components, the components of the traditional Chinese medicine granules are significantly different from those of the anti-infective traditional Chinese medicine granules in the prior art, and can be used for external application to achieve the anti-infective purpose. Furthermore, various traditional Chinese medicines targeting infected bacteria with different characteristics can be used in combination to form a synergistic effect to improve the curative effect and reduce the risk of drug resistance caused by the use of a single drug.

[0015] 2. The traditional Chinese medicine granules of the present invention can also be used for external application. During external application, the main components such as snail mucus and honeysuckle are used. Snail mucus is rich in various active components such as glycosaminoglycans, proteins, growth factors, and repair proteins. These components can act together on damaged tissues, promote the growth and repair of collagen, enhance the elasticity of skin tissues, effectively repair scars, help the skin fight against free radicals, thereby accelerating the wound healing process, and have the effects of clearing heat and detoxifying, promoting blood circulation to remove stasis, and promoting granulation and astringing sores, which is beneficial to the rapid recovery of wounds. Specific Embodiments

[0016] In order to make the technical means, creative features, achieved purposes, and effects of the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0017] The present invention provides a technical solution: an anti-infective traditional Chinese medicine granule and its therapeutic use against drug-resistant bacteria. Its raw materials are in parts by weight and include: 0.5 - 1 part of snail mucus extract, 10 - 15 parts of houttuynia cordata extract, 5 - 10 parts of honey, 8 - 12 parts of honeysuckle flower extract, 6 - 10 parts of forsythia suspensa extract, 8 - 12 parts of scutellaria baicalensis extract, 6 - 10 parts of dandelion extract, 5 - 8 parts of viola philippica extract, 4 - 6 parts of wild chrysanthemum flower extract, 5 - 8 parts of isatis indigotica extract, 4 - 6 parts of andrographis paniculata extract, 8 - 12 parts of oldenlandia diffusa extract, 4 - 6 parts of lobelia chinensis extract, and 2 - 4 parts of licorice extract.

[0018] Further, 0.5 part of snail mucus extract, 10 parts of houttuynia cordata extract, 5 parts of honey, 8 parts of honeysuckle flower extract, 6 parts of forsythia suspensa extract, 8 parts of scutellaria baicalensis extract, 6 parts of dandelion extract, 5 parts of viola philippica extract, 4 parts of wild chrysanthemum flower extract, 5 parts of isatis indigotica extract, 4 parts of andrographis paniculata extract, 8 parts of oldenlandia diffusa extract, 4 parts of lobelia chinensis extract, and 2 parts of licorice extract.

[0019] Further, 0.7 part of snail mucus extract, 12 parts of houttuynia cordata extract, 7 parts of honey, 9 parts of honeysuckle flower extract, 7 parts of forsythia suspensa extract, 9 parts of scutellaria baicalensis extract, 7 parts of dandelion extract, 6 parts of viola philippica extract, 4.5 parts of wild chrysanthemum flower extract, 6 parts of isatis indigotica extract, 4.5 parts of andrographis paniculata extract, 9 parts of oldenlandia diffusa extract, 4.5 parts of lobelia chinensis extract, and 3 parts of licorice extract.

[0020] Further, 0.9 part of snail mucus extract, 13 parts of houttuynia cordata extract, 8 parts of honey, 10 parts of honeysuckle flower extract, 8 parts of forsythia suspensa extract, 10 parts of scutellaria baicalensis extract, 8 parts of dandelion extract, 7 parts of viola philippica extract, 5 parts of wild chrysanthemum flower extract, 7 parts of isatis indigotica extract, 5 parts of andrographis paniculata extract, 10 parts of oldenlandia diffusa extract, 5 parts of lobelia chinensis extract, and 3.5 parts of licorice extract.

[0021] Further, 1 part of snail mucus extract, 14 parts of houttuynia cordata extract, 9 parts of honey, 11 parts of honeysuckle flower extract, 9 parts of forsythia suspensa extract, 11 parts of scutellaria baicalensis extract, 9 parts of dandelion extract, 7.5 parts of viola philippica extract, 5.5 parts of wild chrysanthemum flower extract, 7.5 parts of isatis indigotica extract, 5.5 parts of andrographis paniculata extract, 11 parts of oldenlandia diffusa extract, 5.5 parts of lobelia chinensis extract, and 4 parts of licorice extract.

[0022] Further, 1 part of snail mucus extract, 15 parts of houttuynia cordata extract, 10 parts of honey, 12 parts of honeysuckle flower extract, 10 parts of forsythia suspensa extract, 12 parts of scutellaria baicalensis extract, 10 parts of dandelion extract, 8 parts of viola yedoensis extract, 6 parts of wild chrysanthemum flower extract, 8 parts of isatis indigotica extract, 6 parts of andrographis paniculata extract, 12 parts of oldenlandia diffusa extract, 6 parts of lobelia chinensis extract, 4 parts of licorice extract.

[0023] Example 1

[0024] The anti-infective traditional Chinese medicine granules and their therapeutic use against drug-resistant bacteria include the following raw materials and their weight fractions: 0.5 part of snail mucus extract, 10 parts of houttuynia cordata extract, 5 parts of honey, 8 parts of honeysuckle flower extract, 6 parts of forsythia suspensa extract, 8 parts of scutellaria baicalensis extract, 6 parts of dandelion extract, 5 parts of viola yedoensis extract, 4 parts of wild chrysanthemum flower extract, 5 parts of isatis indigotica extract, 4 parts of andrographis paniculata extract, 8 parts of oldenlandia diffusa extract, 4 parts of lobelia chinensis extract, 2 parts of licorice extract.

[0025] The preparation steps are as follows:

[0026] a. Weigh the above raw materials according to the weight fractions.

[0027] Step 1: Mix the above traditional Chinese medicine extracts evenly according to the ratio. When mixing, stirring or drum rotation can be used for even mixing, and dust reduction treatment should also be noted during mixing.

[0028] Step 2: Add appropriate excipients such as dextrin and sucrose for mixing, and take out for standby after ensuring even mixing.

[0029] Step 3: Use a wet granulator to granulate to obtain traditional Chinese medicine granules.

[0030] Step 4: Dry and size the granules to obtain the final product, and then after passing the quality inspection, carry out packaging and storage.

[0031] Example 2

[0032] The anti-infective traditional Chinese medicine granules and their therapeutic use against drug-resistant bacteria include the following raw materials and their weight fractions: 0.7 part of snail mucus extract, 12 parts of houttuynia cordata extract, 7 parts of honey, 9 parts of honeysuckle flower extract, 7 parts of forsythia suspensa extract, 9 parts of scutellaria baicalensis extract, 7 parts of dandelion extract, 6 parts of viola yedoensis extract, 4.5 parts of wild chrysanthemum flower extract, 6 parts of isatis indigotica extract, 4.5 parts of andrographis paniculata extract, 9 parts of oldenlandia diffusa extract, 4.5 parts of lobelia chinensis extract, 3 parts of licorice extract.

[0033] The preparation steps are as follows:

[0034] a. Weigh the above raw materials according to the weight fractions.

[0035] Step 1: Mix the above-mentioned traditional Chinese medicine extracts evenly according to the ratio. When mixing, stirring or drum rotation can be used for even mixing, and dust reduction treatment should also be noted during mixing;

[0036] Step 2: Add appropriate excipients such as dextrin and sucrose, mix them, and take out for standby after ensuring even mixing;

[0037] Step 3: Use a wet granulator to granulate and obtain traditional Chinese medicine granules;

[0038] Step 4: Dry and size the granules to obtain the final product, and then after passing the quality inspection, package and store them.

[0039] Example 3

[0040] The anti-infective traditional Chinese medicine granules and their therapeutic use against drug-resistant bacteria include the following raw materials and their weight fractions: 0.9 parts of snail mucus extract, 13 parts of houttuynia cordata extract, 8 parts of honey, 10 parts of honeysuckle extract, 8 parts of forsythia extract, 10 parts of scutellaria baicalensis extract, 8 parts of dandelion extract, 7 parts of viola philippica extract, 5 parts of wild chrysanthemum extract, 7 parts of isatis indigotica extract, 5 parts of andrographis paniculata extract, 10 parts of oldenlandia diffusa extract, 5 parts of lobelia chinensis extract, and 3.5 parts of licorice extract.

[0041] The preparation steps are as follows:

[0042] a. Weigh the above raw materials according to the weight parts;

[0043] Step 1: Mix the above-mentioned traditional Chinese medicine extracts evenly according to the ratio. When mixing, stirring or drum rotation can be used for even mixing, and dust reduction treatment should also be noted during mixing;

[0044] Step 2: Add appropriate excipients such as dextrin and sucrose, mix them, and take out for standby after ensuring even mixing;

[0045] Step 3: Use a wet granulator to granulate and obtain traditional Chinese medicine granules;

[0046] Step 4: Dry and size the granules to obtain the final product, and then after passing the quality inspection, package and store them.

[0047] Example 4

[0048] The described anti-infective traditional Chinese medicine granules and their therapeutic use against drug-resistant bacteria include the following raw materials and their weight fractions: 1 part of snail mucus extract, 14 parts of houttuynia cordata extract, 9 parts of honey, 11 parts of honeysuckle extract, 9 parts of forsythia suspensa extract, 11 parts of scutellaria baicalensis extract, 9 parts of dandelion extract, 7.5 parts of viola philippica extract, 5.5 parts of wild chrysanthemum extract, 7.5 parts of isatis indigotica extract, 5.5 parts of andrographis paniculata extract, 11 parts of oldenlandia diffusa extract, 5.5 parts of lobelia chinensis extract, and 4 parts of licorice extract.

[0049] The preparation steps are as follows:

[0050] a. Weigh the above raw materials according to the weight parts.

[0051] Step 1: Mix the above traditional Chinese medicine extracts evenly according to the ratio. When mixing, stirring or roller rotation can be used for even mixing, and dust reduction treatment should also be noted during mixing.

[0052] Step 2: Add appropriate excipients, such as dextrin, sucrose, etc., and mix to ensure even mixing and then take out for standby.

[0053] Step 3: Use a wet granulator to granulate to obtain traditional Chinese medicine granules.

[0054] Step 4: Dry and size the granules to obtain the final product, and then after passing the quality inspection, carry out packaging and storage.

[0055] Example 5

[0056] The described anti-infective traditional Chinese medicine granules and their therapeutic use against drug-resistant bacteria include the following raw materials and their weight fractions: 1 part of snail mucus extract, 15 parts of houttuynia cordata extract, 10 parts of honey, 12 parts of honeysuckle extract, 10 parts of forsythia suspensa extract, 12 parts of scutellaria baicalensis extract, 10 parts of dandelion extract, 8 parts of viola philippica extract, 6 parts of wild chrysanthemum extract, 8 parts of isatis indigotica extract, 6 parts of andrographis paniculata extract, 12 parts of oldenlandia diffusa extract, 6 parts of lobelia chinensis extract, and 4 parts of licorice extract.

[0057] The preparation steps are as follows:

[0058] a. Weigh the above raw materials according to the weight parts.

[0059] Step 1: Mix the above traditional Chinese medicine extracts evenly according to the ratio. When mixing, stirring or roller rotation can be used for even mixing, and dust reduction treatment should also be noted during mixing.

[0060] Step 2: Add appropriate excipients, such as dextrin, sucrose, etc., and mix to ensure even mixing and then take out for standby.

[0061] Step 3: Use a wet granulator to granulate and obtain traditional Chinese medicine granules;

[0062] Step 4: Dry and size the granules to obtain the final product. After passing quality inspection, carry out packaging and storage.

[0063] The data parameter table 1 of traditional anti-infective traditional Chinese medicine granules is as follows:

[0064] Test Items Oral Effect External Application Effect Drug Resistance Parameter Index Good None Average

[0065] The data parameter table 2 of the anti-infective traditional Chinese medicine granules in Example 1 is as follows:

[0066] Test Items Oral Effect External Application Effect Drug Resistance Parameter Index Good Average Excellent

[0067] The data parameter table 3 of the anti-infective traditional Chinese medicine granules in Example 2 is as follows:

[0068] Test Items Oral Effect External Application Effect Drug Resistance Parameter Index Good Good Excellent

[0069] The data parameter table 4 of the anti-infective traditional Chinese medicine granules in Example 3 is as follows:

[0070] Test Items Oral Effect External Application Effect Drug Resistance Parameter Index Excellent Good Excellent

[0071] The data parameter table 5 of the anti-infective traditional Chinese medicine granules in Example 4 is as follows:

[0072] Test Items Oral Effect External Application Effect Drug Resistance Parameter Index Excellent Good Excellent

[0073] The data parameter table 6 of the anti-infective traditional Chinese medicine granules in Example 5 is as follows:

[0074] Test Items Oral Effect External Application Effect Drug Resistance Parameter Index Excellent Excellent Excellent

[0075] In summary, by referring to the data comparison in Table 1, Table 2, Table 3, Table 4, Table 5, and Table 6, it is found that in the present invention, by adding components such as snail mucus, honey, snake bile, and houttuynia cordata, which are not commonly used but have antibacterial and anti-inflammatory effects, to the traditional Chinese medicine components, the components of the traditional Chinese medicine granules are significantly different from those of the existing anti-infective traditional Chinese medicine granules. Furthermore, a variety of traditional Chinese medicines targeting infected bacteria with different characteristics can be used in combination to form a synergistic effect to improve the curative effect and reduce the risk of drug resistance caused by the use of a single drug. When taken orally, it can achieve a good anti-infective effect and has a good effect on drug-resistant pathogens. In addition, in external application, the main components such as snail mucus and honeysuckle, and snail mucus is rich in a variety of active components, such as glycosaminoglycans, proteins, growth factors, and repair proteins. These components can act together on damaged tissues, promote the growth and repair of collagen, enhance the elasticity of skin tissues, effectively repair scars, help the skin fight against free radicals, thus accelerating the wound healing process, and have the effects of clearing heat and detoxifying, promoting blood circulation to remove stasis, and promoting granulation and wound healing, which is beneficial to the rapid recovery of wounds.

[0076] It should also be noted during use that pregnant women, lactating women, and those with allergic constitutions should use it with caution. And if there is any discomfort during use, it should be immediately discontinued and medical attention should be sought.

[0077] The above has shown and described the basic principles, main features, and advantages of the present invention. For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, it is intended to embrace all changes that fall within the meaning and scope of the equivalent elements of the claims in the present invention.

[0078] In addition, it should be understood that although this specification is described according to embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. An anti-infection traditional Chinese medicine granule, characterized in that: It comprises the following components: 0.5 - 1 part of snail mucus extract, 10 - 15 parts of houttuynia cordata extract, 5 - 10 parts of honey, 8 - 12 parts of honeysuckle flower extract, 6 - 10 parts of forsythia suspensa extract, 8 - 12 parts of scutellaria baicalensis extract, 6 - 10 parts of dandelion extract, 5 - 8 parts of viola philippica extract, 4 - 6 parts of wild chrysanthemum flower extract, 5 - 8 parts of folium isatidis extract, 4 - 6 parts of andrographis paniculata extract, 8 - 12 parts of oldenlandia diffusa extract, 4 - 6 parts of lobelia chinensis extract, 2 - 4 parts of licorice extract.

2. The anti-infection traditional Chinese medicine granules according to claim 1, characterized in that: 0.5 part of snail mucus extract, 10 parts of houttuynia cordata extract, 5 parts of honey, 8 parts of honeysuckle flower extract, 6 parts of forsythia suspensa extract, 8 parts of scutellaria baicalensis extract, 6 parts of dandelion extract, 5 parts of viola philippica extract, 4 parts of wild chrysanthemum flower extract, 5 parts of folium isatidis extract, 4 parts of andrographis paniculata extract, 8 parts of oldenlandia diffusa extract, 4 parts of lobelia chinensis extract, 2 parts of licorice extract.

3. The anti-infective traditional Chinese medicine granules according to claim 1, characterized in that: 0.7 part of snail mucus extract, 12 parts of houttuynia cordata extract, 7 parts of honey, 9 parts of honeysuckle flower extract, 7 parts of forsythia suspensa extract, 9 parts of scutellaria baicalensis extract, 7 parts of dandelion extract, 6 parts of viola philippica extract, 4.5 parts of wild chrysanthemum flower extract, 6 parts of folium isatidis extract, 4.5 parts of andrographis paniculata extract, 9 parts of oldenlandia diffusa extract, 4.5 parts of lobelia chinensis extract, 3 parts of licorice extract.

4. The anti-infective traditional Chinese medicine granule according to claim 1, wherein: 0.9 part of snail mucus extract, 13 parts of houttuynia cordata extract, 8 parts of honey, 10 parts of honeysuckle flower extract, 8 parts of forsythia suspensa extract, 10 parts of scutellaria baicalensis extract, 8 parts of dandelion extract, 7 parts of viola philippica extract, 5 parts of wild chrysanthemum flower extract, 7 parts of folium isatidis extract, 5 parts of andrographis paniculata extract, 10 parts of oldenlandia diffusa extract, 5 parts of lobelia chinensis extract, 3.5 parts of licorice extract.

5. The anti-infective traditional Chinese medicine granules according to claim 1, characterized in that: 1 part of snail mucus extract, 14 parts of houttuynia cordata extract, 9 parts of honey, 11 parts of honeysuckle flower extract, 9 parts of forsythia suspensa extract, 11 parts of scutellaria baicalensis extract, 9 parts of dandelion extract, 7.5 parts of viola philippica extract, 5.5 parts of wild chrysanthemum flower extract, 7.5 parts of folium isatidis extract, 5.5 parts of andrographis paniculata extract, 11 parts of oldenlandia diffusa extract, 5.5 parts of lobelia chinensis extract, 4 parts of licorice extract.

6. The anti-infection traditional Chinese medicine granules according to claim 1, characterized in that: 1 part of snail mucus extract, 15 parts of houttuynia cordata extract, 10 parts of honey, 12 parts of honeysuckle flower extract, 10 parts of forsythia suspensa extract, 12 parts of scutellaria baicalensis extract, 10 parts of dandelion extract, 8 parts of viola philippica extract, 6 parts of wild chrysanthemum flower extract, 8 parts of folium isatidis extract, 6 parts of andrographis paniculata extract, 12 parts of oldenlandia diffusa extract, 6 parts of lobelia chinensis extract, 4 parts of licorice extract.

7. Use of the anti - infective traditional Chinese medicine granules according to any one of claims 1 - 6 in the preparation of a drug for treating against drug - resistant bacteria.

8. Use of the anti-infective traditional Chinese medicine granules according to claim 7, characterized in that: The anti - infective traditional Chinese medicine granules can be used for oral administration or external application.