Infusion control early warning method, equipment, medium and system based on electrocardiogram monitoring

Abstract

The invention relates to a transfusion control early warning method, device, medium and system based on electrocardiogram monitoring, and the method comprises the steps: collecting electrocardiogram data of a transfusion person at a fixed time interval, carrying out the electrocardiogram analysis of the electrocardiogram data, and extracting corresponding electrocardiogram parameters; aiming at the electrocardio parameters extracted at each time interval, calculating a mean value and a standard deviation of each electrocardio parameter in the time interval; by taking the mean value and the standard deviation of each electrocardio parameter in the first time interval as a reference, calculating a mean value difference proportion and a standard deviation difference proportion of each subsequent time interval relative to each electrocardio parameter in the first time interval, and further calculating a difference index of each electrocardio parameter corresponding to each subsequent time interval; whether the infusion speed is reduced or not and whether early warning is carried out or not are judged based on whether the difference index of the electrocardio parameters corresponding to the subsequent time intervals exceeds a preset threshold value or not. The infusion speed can be automatically adjusted according to electrocardiogram changes, and medical risks caused by too fast or excessive infusion are prevented.

Description

Technical Field

[0001] The present invention relates to the field of infusion monitoring, and in particular to an infusion control early warning method, device, medium and system based on electrocardiogram monitoring. Background Art

[0002] At present, intravenous infusion is one of the important means of treating diseases in hospitals and other medical institutions. However, the traditional infusion method mainly relies on nurses to regularly patrol to observe the progress of infusion and the patient's response. This method not only increases the workload of medical staff, but also makes it difficult to ensure timely detection and treatment of possible problems. Especially in some special cases, such as rapid infusion, large-scale fluid replacement, or containing high-risk drugs (such as excessive potassium preparations that can cause gradual paralysis of cardiac myocardial cells), if the infusion speed cannot be accurately controlled, it may lead to serious complications and even endanger life safety.

[0003] Traditional infusion monitoring methods mainly rely on manual observation, which makes it difficult to achieve precise control and timely warning. In order to improve the safety and efficiency of the infusion process, some infusion pump products with basic monitoring functions have appeared on the market. However, most of these existing devices can only achieve simple flow control and alarm prompts, and do not really dynamically adjust the infusion strategy according to changes in the patient's physiological state. Summary of the invention

[0004] In order to solve the above problems, the present invention proposes an infusion control early warning method, device, medium and system based on electrocardiogram monitoring.

[0005] The specific plan is as follows:

[0006] An infusion control early warning method based on electrocardiogram monitoring comprises the following steps:

[0007] S1: Collect ECG data of the infusion personnel at fixed time intervals, perform ECG analysis on them, and extract corresponding ECG parameters;

[0008] S2: for each ECG parameter extracted at each time interval, calculate the mean and standard deviation of each ECG parameter within the time interval;

[0009] S3: taking the mean and standard deviation of each ECG parameter in the first time interval as a benchmark, calculating the mean difference ratio and standard deviation difference ratio of each ECG parameter in subsequent time intervals relative to the first time interval, and then calculating the difference index of each ECG parameter corresponding to each subsequent time interval;

[0010] S4: Determine whether to reduce the infusion speed and issue an early warning based on whether the difference index of each ECG parameter corresponding to each subsequent time interval exceeds a preset threshold.

[0011] Furthermore, step S1 also includes preprocessing the collected ECG data before performing ECG analysis, and the preprocessing includes denoising, filtering and baseline correction.

[0012] Furthermore, the ratio of the mean difference of the i-th ECG parameter in the j-th time interval relative to the first time interval is: the ratio of the absolute value of the difference between the mean of the i-th ECG parameter in the j-th time interval and the mean of the i-th ECG parameter in the first time interval to the mean of the i-th ECG parameter in the first time interval; the ratio of the standard deviation difference of the j-th time interval relative to the i-th ECG parameter in the first time interval is: the ratio of the absolute value of the difference between the standard deviation of the i-th ECG parameter in the j-th time interval and the standard deviation of the i-th ECG parameter in the first time interval to the standard deviation of the i-th ECG parameter in the first time interval.

[0013] Furthermore, the difference index of the ith ECG parameter corresponding to the jth time interval is a weighted sum of the mean difference ratio and the standard deviation difference ratio of the ith ECG parameter in the jth time interval relative to the first time interval.

[0014] Furthermore, the preset thresholds correspond to a safety threshold and a critical threshold for each ECG parameter; when the difference index of any ECG parameter corresponding to the j-th time interval is greater than the corresponding safety threshold and less than or equal to the corresponding critical threshold, an instruction to reduce the infusion speed is sent to the automatic infusion device; when the difference index of any ECG parameter corresponding to the j-th time interval is greater than the corresponding critical threshold, an instruction to stop infusion is sent to the automatic infusion device, and an early warning is issued at the same time.

[0015] Furthermore, the preset thresholds are a safety threshold and a critical threshold corresponding to all ECG parameters as a whole; when judging whether to reduce the infusion speed and whether to issue an early warning for the j-th time interval, the weighted sum of the difference indicators of all ECG parameters in the j-th time interval is calculated, and the result is used as the overall difference indicator corresponding to the j-th time interval; when the overall difference indicator corresponding to the j-th time interval is greater than the corresponding safety threshold and less than or equal to the corresponding critical threshold, an instruction to reduce the infusion speed is sent to the automatic infusion device; when the overall difference indicator corresponding to the j-th time interval is greater than the corresponding critical threshold, an instruction to stop infusion is sent to the automatic infusion device, and an early warning is issued at the same time.

[0016] Furthermore, the ECG parameters include: P wave duration, P wave voltage, PR segment interval, QRS wave duration, Q wave voltage, R wave voltage, S wave voltage, ST segment voltage, QT interval, T wave duration, and T wave voltage.

[0017] An infusion control and early warning terminal device based on electrocardiogram monitoring includes a processor, a memory, and a computer program stored in the memory and executable on the processor. When the processor executes the computer program, the steps of the method described above in the embodiment of the present invention are implemented.

[0018] A computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the steps of the method described above in an embodiment of the present invention are implemented.

[0019] An infusion control and early warning system based on electrocardiogram monitoring comprises the above-mentioned infusion control and early warning terminal device based on electrocardiogram monitoring and an automatic infusion device; when the terminal device determines to reduce the infusion speed, it sends an instruction to reduce the infusion speed to the automatic infusion device; when the automatic infusion device receives the instruction to reduce the infusion speed, it reduces the infusion speed according to a preset gradient, and reduces the infusion speed once it receives an instruction to reduce the infusion speed, until it is reduced to a preset infusion speed threshold, and if it still receives an instruction to reduce the infusion speed, it will no longer reduce the infusion speed.

[0020] The present invention adopts the above technical solution, which can monitor the patient's electrocardiogram changes in real time. When the electrocardiogram monitoring parameters exceed the preset safety threshold, the infusion speed is automatically adjusted; when the threshold is exceeded too much, the infusion is automatically stopped and an early warning is issued to notify the nursing staff, thereby effectively preventing medical risks caused by too fast or excessive infusion. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 Shown is a flow chart of a method according to a first embodiment of the present invention.

[0022] Figure 2 A schematic diagram of the method in this embodiment is shown.

[0023] Figure 3 Shown is a schematic diagram of various ECG parameters within a cardiac cycle in this embodiment. DETAILED DESCRIPTION

[0024] To further illustrate various embodiments, the present invention provides drawings. These drawings are part of the disclosure of the present invention, which are mainly used to illustrate the embodiments and can be used in conjunction with the relevant descriptions in the specification to explain the operating principles of the embodiments. With reference to these contents, ordinary technicians in this field should be able to understand other possible implementations and advantages of the present invention.

[0025] The present invention will now be further described with reference to the accompanying drawings and specific implementation methods.

[0026] Embodiment 1:

[0027] The embodiment of the present invention provides an infusion control early warning method based on electrocardiogram monitoring, such as Figure 1 and Figure 2 As shown, the method comprises the following steps:

[0028] S1: Collect the ECG data of the infusion personnel at fixed time intervals, perform ECG analysis on them, and extract the corresponding ECG parameters.

[0029] The collected ECG data may be ECG data output by an ECG monitoring device. In this embodiment, the collected ECG data is preprocessed before ECG analysis, and the preprocessing includes denoising, filtering, baseline correction, etc., to ensure the quality of the ECG data.

[0030] The ECG data can be analyzed using existing ECG analysis algorithms, such as CardioAI, without limitation.

[0031] The ECG parameters extracted in this embodiment include: P wave duration, P wave voltage, PR segment interval, QRS wave duration, Q wave voltage, R wave voltage, S wave voltage, ST segment voltage, QT interval, T wave duration, T wave voltage. Each parameter is in the ECG waveform as shown in Figure 3 shown.

[0032] In this embodiment, the time interval is 10 minutes. In other embodiments, other values ​​may be selected and are not limited here.

[0033] S2: For the ECG parameters extracted at each time interval, the mean and standard deviation of each ECG parameter within the time interval are calculated.

[0034] S3: Taking the mean and standard deviation of each ECG parameter in the first time interval as a benchmark, calculate the mean difference ratio and standard deviation difference ratio of each ECG parameter in subsequent time intervals relative to the first time interval, and then calculate the difference index of each ECG parameter corresponding to each subsequent time interval.

[0035] In this embodiment, the mean (μ) and standard deviation (σ) of each ECG parameter in the first 10 minutes are used as the reference ECG parameter mirror image (μ i , σ i ), which is used to represent the comprehensive characteristics of the overall central tendency and dispersion of the ECG data in the first 10 minutes.

[0036] The mean (μ′) and standard deviation (σ′) of each ECG parameter in each subsequent 10 minutes were used as the control ECG parameter mirror image (μ′ i ,σ′ i ). After that, the control ECG parameter image (μ′) is output every 10 minutes. i ,σ′ i ).

[0037] For the control ECG parameter mirror image (μ′ i ,σ′i ) and the baseline ECG parameter image (μ i , σ i ) in each ECG parameter, calculate its mean difference ratio (Δμ i ) and standard deviation difference ratio (Δσ i ), the formula is as follows:

[0038] (When μ i ≠0)

[0039] (When σ i ≠0)

[0040] The difference index Δ of the i-th ECG parameter i The calculation formula is Δ i =α×Δμ i +(1-α)×Δσ i , where α is a weight coefficient (0≤α≤1) that adjusts the relative importance of mean difference and standard deviation difference.

[0041] S4: Determine whether to reduce the infusion speed and issue an early warning based on whether the difference index of each ECG parameter corresponding to each subsequent time interval exceeds a preset threshold.

[0042] In this embodiment, the threshold has the following two setting modes:

[0043] (1) The first is a single parameter mode, that is, each ECG parameter corresponds to its own unique safety threshold and critical threshold, and the specific settings are shown in Table 1. The specific value of the threshold can be adjusted by those skilled in the art according to the conditions of different patients, and is not limited here.

[0044] Table 1

[0045]

[0046]

[0047] When making a judgment, when the difference index Δ i Greater than the preset safety threshold (T s ) and is less than or equal to the preset emergency threshold (T e ) is the "super-safety threshold", and the difference index Δ of any ECG parameter appears i Greater than the preset critical threshold (T e ) is the “super critical threshold”.

[0048] (2) The second mode is the overall parameter mode. Considering that the effects of different drugs on different parts of the heart may be singular or holistic, the overall parameter mode can be switched in actual use. In the overall parameter mode, no single ECG parameter is judged, but the overall safety threshold (T s , default 5%) and critical threshold (T e , default 10%), then calculate the overall difference index (D) of all ECG parameters by weighted summation, the calculation formula is D = ∑ i (w i ×(α×Δμ i +(1-α)×Δσ i )), where the weight of each parameter (w i ) can be set according to medical expertise or experience and is not limited here.

[0049] When making a judgment, when the overall difference index (D) of all ECG parameters is greater than the preset safety threshold (T s ) and is less than or equal to the preset emergency threshold (T e ) is the “super-safety threshold”, and the overall difference index (D) of all ECG parameters is greater than the preset critical threshold (T e ) is the “super critical threshold”.

[0050] After the above two modes are judged, when the judgment result is "above the safety threshold", an instruction to reduce the infusion speed is sent to the automatic infusion device; when the judgment result is "above the critical threshold", an instruction to stop infusion is sent to the automatic infusion device, and an early warning is issued at the same time.

[0051] It should be noted that when the automatic infusion device receives an instruction to reduce the infusion speed, it can reduce it according to a fixed gradient (i.e., a fixed percentage each time) (such as N%). It will reduce it once it receives an instruction to reduce the infusion speed until it is reduced to a preset infusion speed threshold (such as M%). If it receives another instruction to reduce the infusion speed, it will no longer reduce it. In this embodiment, N is preset to 30 and M is preset to 20. The specific values ​​can be adjusted individually according to the patient's condition and are not limited here. This mechanism can avoid the problem of being unable to infuse due to the patient's temporary drug reaction.

[0052] When the automatic infusion device receives the stop infusion instruction, it stops the infusion immediately.

[0053] A variety of modes can be used for early warning, such as multimedia, sound, light, wireless communication, etc. After receiving the early warning notification, medical staff can reach the patient's infusion site in time and take medical intervention measures according to the patient's current condition to ensure the patient's safety.

[0054] Embodiment 2:

[0055] The present invention also provides an infusion control and early warning terminal device based on electrocardiogram monitoring, comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor implements the steps in the above-mentioned method embodiment of embodiment 1 of the present invention when executing the computer program.

[0056] Further, as an executable solution, the ECG-based infusion control and early warning terminal device can be a computing device such as a desktop computer, a notebook, a PDA, and a cloud server. The ECG-based infusion control and early warning terminal device can include, but is not limited to, a processor and a memory. Those skilled in the art can understand that the composition structure of the ECG-based infusion control and early warning terminal device is only an example of an ECG-based infusion control and early warning terminal device, and does not constitute a limitation on the ECG-based infusion control and early warning terminal device. It can include more or less components than the above, or a combination of certain components, or different components. For example, the ECG-based infusion control and early warning terminal device can also include input and output devices, network access devices, buses, etc., and the embodiments of the present invention do not limit this.

[0057] Further, as an executable solution, the processor may be a central processing unit (CPU), or other general-purpose processors, digital signal processors (DSP), application-specific integrated circuits (ASIC), field-programmable gate arrays (FPGA) or other programmable logic devices, etc. The general-purpose processor may be a microprocessor or any conventional processor, etc. The processor is the control center of the infusion control and early warning terminal device based on electrocardiogram monitoring, and uses various interfaces and lines to connect the various parts of the infusion control and early warning terminal device based on electrocardiogram monitoring.

[0058] The memory can be used to store the computer program and / or module, and the processor realizes various functions of the infusion control and early warning terminal device based on ECG monitoring by running or executing the computer program and / or module stored in the memory, and calling the data stored in the memory. The memory can mainly include a program storage area and a data storage area, wherein the program storage area can store an operating system and an application required for at least one function; the data storage area can store data created according to the use of the mobile phone, etc. In addition, the memory can include a high-speed random access memory, and can also include a non-volatile memory, such as a hard disk, a memory, a plug-in hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (Flash Card), at least one disk storage device, a flash memory device, or other volatile solid-state storage devices.

[0059] Embodiment three:

[0060] The present invention also provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the steps of the above method in the embodiment of the present invention are implemented.

[0061] If the module / unit integrated in the infusion control and early warning terminal device based on ECG monitoring is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the present invention implements all or part of the processes in the above-mentioned embodiment method, and can also be completed by instructing the relevant hardware through a computer program. The computer program can be stored in a computer-readable storage medium, and the computer program can implement the steps of the above-mentioned various method embodiments when executed by the processor. Among them, the computer program includes computer program code, and the computer program code can be in source code form, object code form, executable file or some intermediate form. The computer-readable medium may include: any entity or device that can carry the computer program code, recording medium, U disk, mobile hard disk, disk, optical disk, computer memory, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory) and software distribution medium, etc.

[0062] Embodiment 4:

[0063] The present invention also provides an infusion control and early warning system based on ECG monitoring, the system comprising the infusion control and early warning terminal device based on ECG monitoring in the above-mentioned embodiment 2 and the automatic infusion device mentioned in embodiment 1, the automatic infusion device receives the control instruction sent by the terminal device to control the infusion speed.

[0064] Furthermore, the warning line of sight can be achieved by adding additional warning devices to the system, or by the above-mentioned terminal devices, without limitation here.

[0065] Although the present invention has been specifically shown and described in conjunction with the preferred embodiments, it should be understood by those skilled in the art that various changes may be made to the present invention in form and details without departing from the spirit and scope of the present invention as defined by the appended claims, all of which are within the scope of protection of the present invention.

Claims

1. A method for early warning of infusion control based on electrocardiogram monitoring, characterized in that: The following steps are involved: S1: Collect ECG data of the infusion personnel at fixed time intervals, perform ECG analysis on them, and extract corresponding ECG parameters; S2: for each ECG parameter extracted at each time interval, calculate the mean and standard deviation of each ECG parameter within the time interval; S3: taking the mean and standard deviation of each ECG parameter in the first time interval as a benchmark, calculating the mean difference ratio and standard deviation difference ratio of each ECG parameter in subsequent time intervals relative to the first time interval, and then calculating the difference index of each ECG parameter corresponding to each subsequent time interval; S4: Determine whether to reduce the infusion speed and issue an early warning based on whether the difference index of each ECG parameter corresponding to each subsequent time interval exceeds a preset threshold.

2. The infusion control early warning method based on electrocardiogram monitoring according to claim 1 is characterized in that: Step S1 also includes preprocessing the collected ECG data before performing ECG analysis, and the preprocessing includes denoising, filtering and baseline correction.

3. The infusion control early warning method based on electrocardiogram monitoring according to claim 1 is characterized in that: The ratio of the mean difference of the i-th ECG parameter in the j-th time interval relative to the first time interval is: the ratio of the absolute value of the difference between the mean of the i-th ECG parameter in the j-th time interval and the mean of the i-th ECG parameter in the first time interval to the mean of the i-th ECG parameter in the first time interval; The ratio of the standard deviation difference of the i-th ECG parameter in the j-th time interval relative to the first time interval is: the ratio of the absolute value of the difference between the standard deviation of the i-th ECG parameter in the j-th time interval and the standard deviation of the i-th ECG parameter in the first time interval to the standard deviation of the i-th ECG parameter in the first time interval.

4. The infusion control early warning method based on electrocardiogram monitoring according to claim 1 is characterized in that: The difference index of the ith ECG parameter corresponding to the jth time interval is the weighted sum of the mean difference ratio and the standard deviation difference ratio of the ith ECG parameter in the jth time interval relative to the first time interval.

5. The infusion control early warning method based on electrocardiogram monitoring according to claim 1 is characterized in that: The preset thresholds are that each ECG parameter corresponds to a safety threshold and a critical threshold; when the difference index of any ECG parameter corresponding to the jth time interval is greater than the corresponding safety threshold and less than or equal to the corresponding critical threshold, an instruction to reduce the infusion speed is sent to the automatic infusion device; when the difference index of any ECG parameter corresponding to the jth time interval is greater than the corresponding critical threshold, an instruction to stop infusion is sent to the automatic infusion device and an early warning is issued at the same time.

6. The infusion control early warning method based on electrocardiogram monitoring according to claim 1, characterized in that: The preset thresholds are a safety threshold and a critical threshold corresponding to all ECG parameters as a whole; when judging whether to reduce the infusion speed and whether to issue an early warning for the j-th time interval, the weighted sum of the difference indicators of all ECG parameters in the j-th time interval is calculated, and the result is used as the overall difference indicator corresponding to the j-th time interval; when the overall difference indicator corresponding to the j-th time interval is greater than the corresponding safety threshold and less than or equal to the corresponding critical threshold, an instruction to reduce the infusion speed is sent to the automatic infusion device; when the overall difference indicator corresponding to the j-th time interval is greater than the corresponding critical threshold, an instruction to stop infusion is sent to the automatic infusion device, and an early warning is issued at the same time.

7. The infusion control early warning method based on electrocardiogram monitoring according to claim 1, characterized in that: ECG parameters include: P wave duration, P wave voltage, PR segment interval, QRS wave duration, Q wave voltage, R wave voltage, S wave voltage, ST segment voltage, QT interval, T wave duration, and T wave voltage.

8. An infusion control and early warning terminal device based on electrocardiogram monitoring, characterized in that: The method comprises a processor, a memory and a computer program stored in the memory and running on the processor, wherein the processor implements the steps of the method according to any one of claims 1 to 7 when executing the computer program.

9. A computer-readable storage medium storing a computer program, characterized in that: When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 7 are implemented.

10. An infusion control early warning system based on electrocardiogram monitoring, characterized in that: It includes an infusion control and early warning terminal device based on electrocardiogram monitoring and an automatic infusion device as described in claim 8; when the terminal device determines to reduce the infusion speed, it sends an instruction to reduce the infusion speed to the automatic infusion device; when the automatic infusion device receives the instruction to reduce the infusion speed, it reduces the infusion speed according to a preset gradient, and reduces the infusion speed once it receives an instruction to reduce the infusion speed, until it is reduced to a preset infusion speed threshold, and if it still receives an instruction to reduce the infusion speed, it will no longer reduce the infusion speed.

Images