Donor perfusion device and methods of use thereof

Abstract

The application discloses a donor perfusion device and a method thereof, and belongs to the field of organ transplantation. The donor perfusion device comprises a control host, a blood storage device, a processing assembly and a pump driving assembly. The blood storage device is used for receiving blood input by a donor. The blood is output to the donor after being processed by the processing assembly. The pump driving assembly is in communication with the blood storage device and the processing assembly respectively, so as to drive the blood to be output after flowing through the processing assembly. The pump driving assembly comprises a first pump body and a second pump body, and the first pump body and the second pump body are respectively in communication connection with the control host. The pump driving assembly has a first working condition and a second working condition. In the first working condition, the control host controls the first pump body to work. In the second working condition, the control host controls the second pump body to work. When the first pump body fails, the second pump body can be started as a backup driving source, so that the driving of blood circulation can be continuously completed, and the ischemia phenomenon of the donor for a long time can be avoided.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of organ transplantation, and in particular to a donor perfusion device and a method of using the same. BACKGROUND

[0002] Organ transplantation technology replaces the organs lost due to diseases or injuries by transplanting healthy human organs into patients in need. From early kidney transplantation and liver transplantation to current lung transplantation and heart transplantation, the scope of organ transplantation is expanding, and the technology is becoming increasingly mature.

[0003] In the related art, organ transplantation often involves ex vivo transportation of organs, and a donor perfusion device is needed to simulate the environment of the organ in the human body to maintain the activity of the organ. The donor perfusion device is often provided with a blood pump for driving blood circulation. However, if the blood pump fails during organ transportation or transplantation, it will seriously affect the activity of the organ, and even cause the death of the organ. SUMMARY

[0004] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides a donor perfusion device, which can start the second pump body as a backup driving source when the first pump body fails, thereby continuing to drive the blood circulation to avoid long-term ischemia of the donor.

[0005] The present application also provides a method of using the donor perfusion device.

[0006] The donor perfusion device according to the first aspect of the present application comprises:

[0007] a control host;

[0008] a blood storage device for receiving blood input by a donor;

[0009] a processing assembly in communication with the blood storage device, the blood being output to the donor via the processing assembly;

[0010] a pump drive assembly in communication with the blood storage device and the processing assembly, respectively, to drive the blood to be output after flowing through the processing assembly, the pump drive assembly comprising a first pump body and a second pump body, the first pump body and the second pump body being in communication connection with the control host;

[0011] wherein the pump drive assembly has a first working condition and a second working condition, in the first working condition, the control host controls the first pump body to work, and in the second working condition, the control host controls the second pump body to work.

[0012] The donor perfusion device according to the embodiment of the present application has at least the following beneficial effects:

[0013] The donor perfusion device of the present application can start the second pump body as a backup driving source when the first pump body fails, thereby continuing to drive the blood circulation to avoid long-term ischemia of the donor. The donor perfusion device is more suitable for long-term organ transport scenarios, and the redundant design of the pump driving assembly ensures the stable operation of the donor perfusion device under complex conditions, thereby improving the reliability of the donor perfusion device.

[0014] According to some embodiments of the present application, the donor perfusion device comprises an output pipeline, one end of the output pipeline being in communication with the processing assembly, and the other end being used to communicate with the donor, the output pipeline being provided with a sensor in communication connection with the control host, the control host acquiring physiological parameters collected by the sensor, and if the physiological parameters are outside the set range, the control host controls the pump driving assembly to switch from the first working condition to the second working condition.

[0015] Alternatively, the control host acquires the working parameters of the first pump body, and if the working parameters are outside the set range, the control host controls the pump driving assembly to switch from the first working condition to the second working condition.

[0016] According to some embodiments of the present application, after the control host switches from the first working condition to the second working condition, the current working condition is set as the first working condition, the second pump body is set as a new first pump body, and the first pump body is set as a new second pump body.

[0017] According to some embodiments of the present application, the pump driving assembly comprises a first pump head capable of being detachably connected with any one of the first pump body and the second pump body, the first pump body and the second pump body are capable of driving the first pump head to operate, the first pump head is in communication with the blood storage device and the processing assembly respectively, in the first working condition, the first pump head is connected with the first pump body, and in the second working condition, the first pump head is connected with the second pump body.

[0018] According to some embodiments of the present application, the pump driving assembly comprises a first pump head connected with the first pump body, the first pump head is in communication with the blood storage device and the processing assembly respectively, the pump driving assembly further comprises a second pump head connected with the second pump body, the second pump head is in communication with the blood storage device and the processing assembly respectively, in the first working condition, the blood storage device, the first pump head and the processing assembly form a passage, and in the second working condition, the blood storage device, the second pump head and the processing assembly form a passage.

[0019] According to some embodiments of the present application, the pump driving assembly further comprises an input three-way valve and an output three-way valve, each port of the input three-way valve is in communication with the blood reservoir, the input port of the first pump head and the input port of the second pump head respectively, each port of the output three-way valve is in communication with the processing assembly, the output port of the first pump head and the output port of the second pump head respectively;

[0020] Wherein, the input three-way valve and the output three-way valve are respectively in communication connection with the control host and are controlled by the control host to switch the on-off state, in the first working condition, the blood reservoir, the input port of the first pump head, the output port of the first pump head and the processing assembly are sequentially communicated, in the second working condition, the blood reservoir, the input port of the second pump head, the output port of the second pump head and the processing assembly are sequentially communicated.

[0021] According to some embodiments of the present application, the donor perfusion device comprises an input pipeline in communication with the blood reservoir and an output pipeline in communication with the processing assembly, the donor perfusion device comprises a self-circulation mode and an external circulation mode, in the self-circulation mode, the input pipeline and the output pipeline are communicated, in the external circulation mode, the input pipeline is used to communicate with the donor and the output pipeline is used to communicate with the donor;

[0022] The donor perfusion device switches to the external circulation mode after a set time of executing the self-circulation mode, wherein, in the self-circulation mode, the control host controls the pump driving assembly to switch at least once.

[0023] According to some embodiments of the present application, the donor perfusion device comprises an input pipeline in communication with the blood reservoir and an output pipeline in communication with the processing assembly, the output pipeline is used to communicate with the donor;

[0024] Wherein, the donor perfusion device further comprises a circulation pipeline, one end of the circulation pipeline is in communication with the blood reservoir and the other end is in communication with the processing assembly, when the output pipeline and the input pipeline are ready to communicate with the donor, at least the output pipeline is closed and the circulation pipeline is opened, after the output pipeline communicates with the donor, the circulation pipeline is closed.

[0025] According to some embodiments of the present application, the donor perfusion device further comprises a trolley, the trolley is provided with a mounting table, the mounting table is provided with a clamping assembly, opposite side walls of the control host are respectively provided with clamping grooves, when the control host is placed on the mounting table, the clamping assembly is clamped with the clamping grooves.

[0026] According to some embodiments of the present application, the mounting table comprises a first shell and a second shell, the first shell and the second shell defining a transmission cavity, the mounting table further comprising a clamping piece, an elastic piece, an adapter and a button movably connected with the first shell, the elastic piece being connected with the clamping piece, the clamping piece and the adapter being rotatably connected with the second shell respectively;

[0027] The clamping piece has a first state of partially protruding from the first shell under the driving of the elastic piece, in the first state, the protruding part of the clamping piece can be embedded in the clamping groove to limit the movement of the control host; and the clamping piece also has a second state of being withdrawn to the first shell under the driving of the adapter, in the second state, the clamping piece is located outside the clamping groove, and the control host can be separated from the mounting table; the button is configured to drive the adapter to rotate when pressed, so as to drive the clamping piece to switch from the first state to the second state.

[0028] According to some embodiments of the present application, the trolley is further provided with a mounting rod and a mounting bracket arranged on the mounting rod, the mounting bracket comprising a first body part sleeved on the mounting rod, a second body part rotatably connected with the first body part, a first locking part mounted on the first body part, and a second locking part mounted on the first body part or the second body part, the first locking part being configured to movably connect the first body part with the mounting rod when loosened, and fix the first body part and the mounting rod when tightened; the second locking part is configured to rotatably connect the second body part with the first body part when loosened, and fix the first body part and the second body part when tightened.

[0029] The method for using the donor perfusion device according to the second aspect of the present application is applied to any one of the donor perfusion devices described in the above embodiments, and comprises the following steps:

[0030] Mounting consumables;

[0031] Turning on the control host switch and performing self-checking;

[0032] Supplementing the pre-charging liquid into the blood storage device, so that the donor perfusion device switches to the self-circulation mode;

[0033] Supplementing blood into the blood storage device, so that the donor perfusion device enters the external circulation mode.

[0034] Additional aspects and advantages of the present application will be in part apparent and in part pointed out hereinafter. BRIEF DESCRIPTION OF DRAWINGS

[0035] The present application will be further described in conjunction with the accompanying drawings and embodiments, in which:

[0036] Figure 1 A schematic diagram of the structure of the donor perfusion device of the present application;

[0037] Figure 2 A schematic diagram of the pipeline and circuit of the donor perfusion device of the present application;

[0038] Figure 3 A schematic diagram of the consumable part of the donor perfusion device of the present application;

[0039] Figure 4 A schematic diagram of the structure of the double pump head embodiment of the donor perfusion device of the present application;

[0040] Figure 5 An exploded schematic diagram of the control host and mounting table of the present application;

[0041] Figure 6 A schematic diagram of the control host and mounting table of the present application; Figure 5

[0042] Figure 7 A schematic diagram of the control host and mounting table of the present application;

[0043] Figure 8 A schematic diagram of the control host and mounting table of the present application; Figure 7

[0044] A schematic diagram of the control host and mounting table of the present application; Figure 9

[0045] A schematic diagram of the control host and mounting table of the present application; Figure 10 Figure 9 A schematic diagram of the control host and mounting table of the present application;

[0046] Figure 11 A schematic diagram of the mounting of the blood storage device of the present application;

[0047] Figure 12 A schematic diagram of the structure of the pipeline clamp of the present application.

[0048] Reference signs:

[0049] Control host 100; clamping groove 110;

[0050] Blood storage device 200; input pipeline 210; venous pressure sensor 211; liquid level sensor 220;

[0051] Processing assembly 300; oxygenator 310; air-oxygen mixer 311; air storage cylinder 312; oxygen storage cylinder 313; heater 320; heated water tank 321; filter 330; output pipeline 331; arterial pressure sensor 332; circulation pipeline 333;​​

[0052] pump drive assembly 400; first pump body 410; second pump body 420; first pump head 430; flow sensor 440; second pump head 450; input three-way valve 460; output three-way valve 470;

[0053] trolley 500; mounting table 510; first housing 511; second housing 512; clamping piece 513; first section 5131; second section 5132; limiting protrusion 5133; elastic piece 514; adapter piece 515; first adapter section 5151; second adapter section 5152; button 516; mounting rod 520; mounting bracket 530; first main body part 531; second main body part 532; first locking part 533; second locking part 534;

[0054] pipe clamp 600; fixing section 610; clamping protrusion 611; elastic section 620; abutting protrusion 630; DETAILED DESCRIPTION

[0055] Embodiments of the present application are described below in detail, examples of which are shown in the drawings, wherein the same or similar notations represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary, only for explaining the present application, and cannot be understood as a limitation of the present application.

[0056] In the description of the present application, it is understood that the orientation description, such as the orientation or position relationship indicated by up, down, front, back, left, right, etc. is based on the orientation or position relationship shown in the drawings, only for the convenience of describing the present application and simplifying the description, and is not intended to indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation of the present application.

[0057] In the description of the present application, if the meaning of several is more than one, the meaning of multiple is more than two, greater than, less than, more than, etc. is not included in the number, above, below, etc. is understood to include the number. If it is described as first, second, only for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features or implicitly indicating the order of indicated technical features.

[0058] In the description of the present application, unless otherwise explicitly limited, the words such as setting, mounting, connecting, etc. should be broadly understood, and the person skilled in the art can reasonably determine the specific meaning of the above words in the present application in combination with the specific content of the technical solution.

[0059] In the description of this invention, the terms "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0060] Organ transplantation technology involves transplanting healthy human organs into patients in need, replacing organs that have lost function due to disease or injury. From early kidney and liver transplants to current lung and heart transplants, the scope of organ transplantation has been continuously expanding, and the technology has become increasingly sophisticated.

[0061] In related technologies, organ transplantation often involves the ex vivo transport of organs, requiring the use of donor perfusion devices to simulate the organ's environment within the human body, thereby maintaining organ viability. Donor perfusion devices are typically equipped with a blood pump to drive blood circulation; however, if the blood pump malfunctions during organ transport or transplantation, it can severely affect organ viability and even cause organ death.

[0062] To address the aforementioned problems, this application proposes a donor perfusion device, which includes a control unit 100, a blood reservoir 200, a processing component 300, a pump drive component 400, etc. Figures 1 to 3 The diagram shown is an overall schematic of the operation of the donor infusion device. Figure 2 As shown, the blood reservoir 200 is connected to an input conduit 210, which connects to the vein of the donor (i.e., an excised organ, not shown in the figure), allowing venous blood to flow from the input conduit 210 into the blood reservoir 200. The blood reservoir 200 receives and stores the blood input from the donor. Downstream of the blood reservoir 200 is a pump drive assembly 400, and downstream of the pump drive assembly 400 is a processing assembly 300. It should be noted that the upstream and downstream designations used herein refer to the direction of blood flow in the donor perfusion device. For example, "downstream of the blood reservoir 200 is connected to the pump drive assembly 400" means that the blood first flows through the blood reservoir 200 and then to the pump drive assembly 400.

[0063] The pump drive assembly 400 is used to drive blood circulation and provide the donor with blood pressure similar to that of the human body. The pump drive assembly 400 is connected to the blood reservoir 200 and the processing assembly 300 through pipes, so as to drive the blood to flow through the processing assembly 300 and then output it to the donor.

[0064] The processing assembly 300 includes, but is not limited to, an oxygenator 310, a heater 320, a filter 330, etc., for processing the venous blood flowing out of the donor to form arterial blood with higher oxygen content and appropriate temperature, and inputting the arterial blood into the arterial blood vessel of the donor through an output pipeline 331 in communication with the processing assembly 300, so as to complete the blood circulation of the donor.

[0065] In the embodiment as shown in the figure, the oxygenator 310 is in communication with an air-oxygen mixer 311, the air-oxygen mixer 311 is in communication with an air cylinder 312 and an oxygen cylinder 313 respectively, and the gases in the air cylinder 312 and the oxygen cylinder 313 are mixed in the air-oxygen mixer 311 at a set ratio and then input into the oxygenator 310 to be mixed with the blood. Figures 1 to 3

[0066] The heater 320 is in communication with a heating water tank 321, the heating water tank 321 can provide warm water with appropriate temperature for the heater 320 and recover and heat the cooling water in the heater 320. The heater 320 performs water bath heating on the blood flowing through the pipeline through the warm water provided by the heating water tank 321, and has good temperature stability.

[0067] The whole donor perfusion device is also provided with a plurality of sensors, and the control host 100 is in communication connection with each sensor (such as the liquid level sensor 220 on the blood storage device 200, the arterial pressure sensor 332 on the output pipeline 331, etc.) and each component (such as the first pump body 410, the air-oxygen mixer 311, etc.), so as to realize information collection and control of the whole donor perfusion device.

[0068] It should be noted that the pump drive assembly 400 of the present application includes two blood pumps, which are named as the first pump body 410 and the second pump body 420 for easy distinction, and the first pump body 410 and the second pump body 420 are in communication connection with the control host 100 respectively, and the control host 100 can control the start-stop and rotating speed of the first pump body 410 and the second pump body 420. The pump drive assembly 400 has a first working condition and a second working condition, in the initial state, the pump drive assembly 400 is in the first working condition, the control host 100 controls the first pump body 410 to work and the second pump body 420 to stop working, and the blood is driven by the first pump body 410. When the first pump body 410 fails, the pump drive assembly 400 switches to the second working condition, at this time, the control host 100 controls the second pump body 420 to work and the first pump body 410 to stop working, and the blood is driven by the second pump body 420.

[0069] ​Based on the above, when the first pump 410 fails, the donor perfusion device of this application can activate the second pump 420 as a backup drive source to continue driving blood circulation and avoid prolonged ischemia in the donor. This donor perfusion device is well-suited for long-term organ transport scenarios. The redundant design of the pump drive assembly 400 ensures stable operation of the donor perfusion device under complex conditions, improving its reliability.

[0070] It is understood that the control host 100 can monitor the physiological parameters of the blood in the donor perfusion device or the operating parameters of the blood pump, thereby promptly alarming when the first pump body 410 malfunctions and switching the operating conditions of the pump drive assembly 400. In some embodiments, such as Figure 2 As shown, the donor perfusion device includes an output pipe 331. One end of the output pipe 331 is connected to the processing component 300, and the other end is connected to the donor. A sensor is installed on the output pipe 331, and the sensor is communicatively connected to the control host 100, thereby enabling the control host 100 to acquire the physiological parameters collected by the sensor. For example, the sensor can be a pressure sensor, capable of acquiring the pressure value of the blood in the output pipe 331; or, the sensor can be a flow rate sensor, capable of acquiring the flow rate of the blood in the output pipe 331.

[0071] The control host 100 acquires the physiological parameter values ​​collected by the sensor at set intervals, or it can acquire the physiological parameter values ​​collected by the sensor in real time. The acquired data is compared with the preset range. If the physiological parameter value exceeds the preset range, it is determined that the first pump body 410 is malfunctioning. The control host 100 then controls the second pump body 420 to work and the first pump body 410 to stop working, so that the pump drive assembly 400 switches from the first working condition to the second working condition.

[0072] Alternatively, in other embodiments, the control host 100 may acquire the operating parameters of the first pump body 410 at set intervals or in real time, such as the voltage value and speed value of the first pump body 410, and compare the acquired data with a preset range. If the operating parameters exceed the preset range, the control host 100 controls the pump drive assembly 400 to switch from the first operating condition to the second operating condition.

[0073] In some embodiments, after the control host 100 controls the pump drive assembly 400 to switch from the first operating condition to the second operating condition, the first pump body 410 needs to be repaired or replaced, and then the pump drive assembly 400 is switched back from the second operating condition to the first operating condition. In this embodiment, the second pump body 420 can be a lower-cost blood pump for backup. The second pump body 420 only plays a temporary driving role and does not undertake long-term driving tasks.

[0074] In other embodiments, after the control host 100 switches from the first operating condition to the second operating condition, the first pump 410 is in a non-operating state. At this time, staff can repair or replace the first pump 410 to prevent malfunctions in the second pump 420. When the control host 100 continues to drive blood flow using the second pump 420, the control host 100 sets the current operating condition back to the first operating condition, sets the second pump 420 as the new first pump 410, and sets the first pump 410 as the new second pump 420. In this method, both the first pump 410 and the second pump 420 can undertake long-term driving tasks. Even after the original first pump 410 is repaired, there is no need to switch back to the original first pump 410 for driving, reducing the number of operating condition switches and improving the stability of the entire donor perfusion device.

[0075] Based on the foregoing, when the control host 100 detects an abnormality in the first pump body 410, it issues an alarm and controls the second pump body 420 to start working while the first pump body 410 stops working. In some embodiments, after receiving the warning information, the operator needs to cooperate with the control host 100 to complete the switching of the operating conditions of the pump drive assembly 400. Specifically, such as... Figure 1 As shown, the pump drive assembly 400 includes a first pump body 410, a second pump body 420, and a first pump head 430. The first pump head 430 can be detachably connected to the first pump body 410 or the second pump body 420. Both the first pump body 410 and the second pump body 420 can drive the first pump head 430 to operate. More specifically, the first pump head 430 contains an impeller (not shown in the figure). Both the first pump body 410 and the second pump body 420 adopt a magnetic drive structure. When the first pump head 430 is installed on the first pump body 410 or the second pump body 420, the first pump body 410 or the second pump body 420 can drive the impeller in the first pump head 430 to rotate, thereby promoting accelerated blood flow.

[0076] The first pump head 430 includes an inlet end and an outlet end. The inlet end is connected to the blood reservoir 200, and the outlet end is connected to the processing component 300. Blood enters the first pump head 430 from the inlet end and flows out from the outlet end via an impeller drive. It is understood that, depending on the operating conditions of the pump drive component 400, the first pump head 430 is selectively connected to either the first pump body 410 or the second pump body 420. That is, in the first operating condition, the first pump head 430 is connected to the first pump body 410. When the control host 100 detects a malfunction in the first pump body 410 that prevents it from completing the drive task as required, it issues an alarm to remind the operator. The operator then removes the first pump head 430 from the first pump body 410 and installs it on the second pump body 420. The control host 100 then controls the second pump body 420 to operate, thereby achieving a change in the drive source.

[0077] The embodiment of the shared first pump body 410 has a simple structure, and blood flows along a fixed path of the blood storage device 200, the first pump head 430 and the processing assembly 300, without the need to change the flow path, thereby reducing the connection pipeline of the donor perfusion device, being low in cost and simple in operation.

[0078] Correspondingly, another working condition switching mode is also provided in the present application, in which the donor perfusion device does not need to change the pump head while changing the driving source. Specifically, as shown in Figure 4 The pump driving assembly 400 includes two pump heads, which are named as the first pump head 430 and the second pump head 450 for convenience. The first pump head 430 is connected with the first pump body 410, and the first pump head 430 is in communication with the blood storage device 200 and the processing assembly 300, respectively. The second pump head 450 is connected with the second pump body 420, and the second pump head 450 is also in communication with the blood storage device 200 and the processing assembly 300, respectively. That is, between the blood storage device 200 and the processing assembly 300, there are two parallel pipelines respectively flowing through the first pump head 430 and the second pump head 450. In the first working condition, the blood storage device 200, the first pump head 430 and the processing assembly 300 form a passage capable of circulating blood, and the blood storage device 200, the second pump head 450 and the processing assembly 300 are closed and cannot circulate blood. In the second working condition, the blood storage device 200, the second pump head 450 and the processing assembly 300 form a passage capable of circulating blood, and the blood storage device 200, the first pump head 430 and the processing assembly 300 are closed and cannot circulate blood.

[0079] The two parallel pipelines are opened alternatively, and the other one is closed. The closing mode can be manual, for example, the operator uses the pipeline clamp to lock the liquid inlet pipe of the first pump head 430 or the liquid outlet pipe of the first pump head 430 after receiving the warning information of the control host 100. Alternatively, the closing mode can also be automatic, for example, as shown in Figure 4 The pump driving assembly 400 also includes two electric three-way valves, which are set as an input three-way valve 460 and an output three-way valve 470 for convenience. The three ports of the input three-way valve 460 are in communication with the blood storage device 200, the input port of the first pump head 430 and the input port of the second pump head 450, respectively. The three ports of the output three-way valve 470 are in communication with the processing assembly 300, the output port of the first pump head 430 and the output port of the second pump head 450, respectively.

[0080] The input three-way valve 460 and the output three-way valve 470 are respectively connected with the control host 100 in communication and are controlled to switch the on-off state by the control host 100. In the first working condition, the input three-way valve 460 connects the blood reservoir 200 with the input port of the first pump head 430 and closes the input port of the second pump head 450, and the output three-way valve 470 connects the output port of the first pump head 430 with the processing assembly 300 and closes the output port of the second pump head 450 to avoid blood backflow. Thus, in the first working condition, blood can pass through the blood reservoir 200, the input port of the first pump head 430, the output port of the first pump head 430 and the processing assembly 300 in sequence. Similarly, in the second working condition, the input three-way valve 460 connects the blood reservoir 200 with the input port of the second pump head 450, and the output three-way valve 470 connects the output port of the second pump head 450 with the processing assembly 300, so that blood can pass through the blood reservoir 200, the input port of the second pump head 450, the output port of the second pump head 450 and the processing assembly 300 in sequence.

[0081] It can be understood that, by arranging the input three-way valve 460 and the output three-way valve 470, automatic switching of the two parallel pipelines can be realized, so that when the first pump body 410 fails, blood can be automatically guided to the pipeline connected with the second pump body 420, efficient and automatic switching is realized, the replacement time of the driving source is greatly shortened, and the adverse effect of replacing the driving source on the donor is reduced. Moreover, when the first pump head 430 is blocked or fails, the structure in the embodiment can also realize replacement of the driving source, so that the influence on the donor is avoided.

[0082] It should be noted that, in the present application, the blood reservoir 200, the connecting pipeline for blood circulation and the like are all disposable consumables. Therefore, after replacing the consumables each time, the air in the pipeline needs to be discharged before being connected with the donor, so as to avoid that the air in the pipeline is filled into the donor to cause air embolism and damage to the isolated organ. Therefore, the donor perfusion device of the present application includes a self-circulation mode and an external circulation mode. The self-circulation mode is used to discharge the air in the pipeline, and the external circulation mode is used to connect the donor to supply blood. In the self-circulation mode, pre-charged liquid is filled into the blood reservoir 200, and the pre-charged liquid is circulated to discharge the gas in the pipeline. The input pipeline 210 and the output pipeline 331 are connected in communication, so that the pre-charged liquid can circulate in the donor perfusion device and flow back to the blood reservoir 200 through the blood reservoir 200, the pump driving assembly 400, the processing assembly 300, the output pipeline 331 and the input pipeline 210, and the air is released in the blood reservoir 200. It should be explained that the input pipeline 210 and the output pipeline 331 can be an integrally formed pipeline and are connected in communication in the self-circulation mode. When it is needed to be connected with the donor, they are cut off to be independent input pipeline 210 and output pipeline 331.

[0083] It can be understood that, due to the two parallel pipelines and two sets of driving sources arranged in the blood storage device 200 and the processing assembly 300 in the embodiment of the present application, the two parallel pipelines and the driving sources need to be respectively subjected to air exhausting treatment in the early self-circulation mode, that is, the control host 100 controls the pump driving assembly 400 to switch at least once in the working condition in the self-circulation mode. It needs to be explained that, the working condition switching is actively triggered by the program, and does not need to be passively triggered after the control host 100 detects an abnormal condition. For example, after the pump driving assembly 400 drives the first pump body 410 and the first pump head 430 to pre-charge liquid for a period of time, the control host 100 actively controls the pump driving assembly 400 to switch to the second working condition, and the second pump body 420 and the second pump head 450 are used to drive the pre-charge liquid, so as to exhaust the air in the pipeline where the second pump head 450 is located.

[0084] In some embodiments, as shown in Figure 2 , the donor perfusion device further comprises a circulation pipeline 333, one end of the circulation pipeline 333 is in communication with the blood storage device 200, and the other end is in communication with the processing assembly 300. When the output pipeline 331 and the input pipeline 210 are ready to be communicated with the donor, at this time, the output pipeline 331 and the input pipeline 210 need to be separated, and the input pipeline 210 is inserted into the venous blood vessel of the donor, and the output pipeline 331 is inserted into the arterial blood vessel of the donor. During the insertion process, in order to ensure the butt joint of the output pipeline 331 and the arterial blood vessel, the blood flow in the output pipeline 331 needs to be temporarily stopped, at this time, the output pipeline 331 is closed by the pipeline clamp 600, and the circulation pipeline 333 is opened, so that the blood can flow back to the blood storage device 200 from the circulation pipeline 333, and cannot flow out through the output pipeline 331. After the output pipeline 331 is communicated with the donor, the circulation pipeline 333 is closed by the pipeline clamp 600, so that the blood no longer flows back through the circulation pipeline 333, but is directly output to the blood vessel of the donor.

[0085] In the embodiment as shown in Figure 2 , the outlet pipe of the filter 330 is connected with a three-way joint, one port of the three-way joint is in communication with the output pipeline 331, and the other port is in communication with the circulation pipeline 333.

[0086] In more detail, as shown in Figure 3 and Figure 12In the shown embodiment, the pipe clamp 600 is integrally formed by injection molding of plastic material, and comprises a fixed section 610 and an elastic section 620 connected with the fixed section 610. The fixed section 610 is provided with a through hole for the pipe to pass through, and the pipe is arranged in the fixed section 610 and partially located between the fixed section 610 and the elastic section 620. The fixed section 610 and the elastic section 620 are respectively provided with oppositely arranged abutting protrusions 630. One end of the elastic section 620 is integrally connected with the fixed section 610, and the other end can be clamped with the fixed section 610, so that the abutting protrusions 630 on the fixed section 610 and the elastic section 620 respectively abut against the two sides of the pipe to reduce the cross-sectional area of the pipe. In addition, the fixed section 610 is provided with a plurality of clamping protrusions 611 for clamping with the elastic section 620. When the elastic section 620 is clamped with different clamping protrusions 611, the abutting degree of the abutting protrusions 630 on the elastic section 620 and the fixed section 610 against the pipe changes accordingly. When at least one clamping protrusion 611 abuts against the elastic section 620, the abutting protrusions 630 on both sides abut against the pipe walls on both sides of the pipe to completely close the pipe.

[0087] In some embodiments, as shown in Figure 1 , Figures 5 to 11 The donor perfusion device further comprises a trolley 500, which is provided with rollers to facilitate movement. The trolley 500 is provided with a mounting table 510, and the mounting table 510 is provided with a clamping assembly. Opposite side walls of the control host 100 are respectively provided with clamping grooves 110, and the clamping assembly is used for clamping the clamping grooves 110 when the control host 100 is placed on the mounting table 510. When the control host 100 is mounted on the mounting table 510 of the trolley 500, its displacement is limited by the clamping assembly, thereby reducing the risk of falling damage of the control host 100 during transportation. Moreover, the control host 100 is arranged on the trolley 500, which is conducive to the movement of the control host 100 by the operator, and greatly improves the convenience of transportation of the donor perfusion device.

[0088] Specifically, as shown in Figure 5 and Figure 6 The mounting table 510 comprises a first housing 511 and a second housing 512. As shown in Figure 5 The first housing 511 is a housing structure, and the lower end thereof is provided with an opening. The second housing 512 can be detachably connected with the first housing 511, and covers and closes the lower end opening of the first housing 511, so that the first housing 511 and the second housing 512 jointly define a transmission cavity. The mounting table 510 further comprises a clamping piece 513, an elastic piece 514 and an adapter 515 arranged in the transmission cavity. The mounting table 510 further comprises a button 516 movably connected with the first housing 511.

[0089] The clamping piece 513 is as shown in Figure 7 and Figure 8The shape shown includes a first section 5131 and a second section 5132 integrally formed and intersected, the first section 5131 is used to abut with the adapter 515, the end of the second section 5132 includes a protruding limiting protrusion 5133, the first shell 511 is provided with an opening, and the clamping piece 513 is rotationally connected with the second shell 512. The elastic piece 514 is connected with the clamping piece 513, and the elastic piece 514 can be a torsion spring. The elastic piece 514 is used to maintain the clamping piece 513 in a state that the limiting protrusion 5133 protrudes out of the opening. As shown in Figure 9 and Figure 10 The one end of the adapter 515 can abut with the first section 5131 of the clamping piece 513, so as to drive the clamping piece 513 to rotate and compress the elastic piece 514, the other end of the adapter 515 can abut with the key 516, the middle part of the adapter 515 is rotationally connected with the second shell 512, and can rotate with the middle part of the adapter 515 as a rotation fulcrum, so that the pressing of the key 516 can drive the adapter 515 to rotate, and drive the first section 5131 of the clamping piece 513 at the other end to rotate upward, so that the limiting protrusion 5133 of the second section 5132 is withdrawn into the first shell 511.

[0090] It can be understood that the number of the clamping piece 513 and the elastic piece 514 can be two, and the adapter 515 and the key 516 can be provided with one, as shown in Figure 6 The adapter 515 includes a first adapter section 5151 used to abut with the key 516 and a second adapter section 5152 used to abut with the clamping piece 513, the first adapter section 5151 and the second adapter section 5152 are fixedly connected, and the first adapter section 5151 is connected with the middle part of the second adapter section 5152, so that the two ends of the second adapter section 5152 can abut with one clamping piece 513 respectively, so as to limit the control host 100 in cooperation with the clamping grooves 110 on both sides of the control host 100.

[0091] For the convenience of description, the two states of the clamping piece 513 are respectively named as a first state and a second state, the first state is a long-term state that the clamping piece 513 can maintain when it is not subjected to the action force of the key 516 pressed by the operator, in this state, the clamping piece 513 is driven by the elastic piece 514 to maintain in a position partially protruding from the first shell 511, and the part of the clamping piece 513 protruding from the first shell 511 (i.e. the limiting protrusion 5133 mentioned above) can be embedded into the clamping groove 110 on the side of the control host 100, so as to limit the movement of the control host 100. In the second state, as shown in Figure 8The second adapter segment 5152 of the adapter 515 is shown to move upward to cause the clamping piece 513 to rotate clockwise, so that the limiting protrusion 5133 is withdrawn into the first housing 511, and the clamping piece 513 is withdrawn from the clamping slot 110, so that the control host 100 can be separated from the mounting table 510. It should be noted that the button 516 is arranged to protrude from the surface of the first housing 511 when the button 516 is not pressed by the elastic piece 514 and the abutting of the adapter 515. The operator can press the button 516 to cause the end of the adapter 515 abutting the button 516 to move downward, and the other end to move upward, so as to drive the clamping piece 513 to switch from the first state to the second state.

[0092] In addition, the trolley 500 is further provided with a mounting rod 520 and a mounting bracket 530 arranged on the mounting rod 520, for mounting the pump drive assembly 400 and the blood storage device 200 and the like. Thus, the trolley 500 can realize integrated mounting of various machines in the donor perfusion device, which is conducive to unified transportation during transportation.

[0093] Specifically, as shown in Figure 1 and Figure 11 The mounting rod 520 is arranged in the vertical direction, the mounting bracket 530 includes a first body part 531, a second body part 532, a first locking part 533 and a second locking part 534, the first body part 531 is sleeved on the mounting rod 520, the second body part 532 is rotatably connected with the first body part 531, the first locking part 533 is threadedly connected with the first body part 531, when the first locking part 533 is gradually tightened, the first locking part 533 can pass through the first body part 531 and abut against the mounting rod 520, so as to fixedly connect the first body part 531 and the mounting rod 520, thereby limiting the position of the first body part 531 on the mounting rod 520. When the first locking part 533 is loosened, the first locking part 533 is separated from the mounting rod 520, so that the first body part 531 can rotate or move up and down relative to the mounting rod 520. The second locking part 534 can be threadedly connected with any one of the first body part 531 and the second body part 532, for example, as shown in Figure 11 The second locking part 534 is threadedly connected with the first body part 531, when the second locking part 534 is tightened, the second locking part 534 passes through the first body part 531 and abuts against the second body part 532, so as to fixedly connect the first body part 531 and the second body part 532, thereby limiting the rotation freedom degree of the second body part 532 relative to the first body part 531. When the second locking part 534 is loosened, the second body part 532 can rotate relative to the first body part 531.

[0094] It can be understood that, through the arrangement of the first locking part 533 and the second locking part 534, the installation of the blood storage device 200, the pump drive assembly 400 and the like has a relatively large free adjustment space, which can meet the use requirements of the operating personnel in different scenes. In addition, the second main body part 532 can adopt different structures to adapt to the connection with different devices. For example, in the embodiment shown in Figure 1 , the second main body part 532 connected with the pump drive assembly 400 is a straight plate structure, which is attached to the lower wall surface of the pump body and fixed with the pump body through screws. As shown in Figure 11 , the second main body part 532 connected with the blood storage device 200 is a ring structure, and when installed, the blood storage device 200 can be arranged in the second main body part 532 and abut against the second main body part 532, so as to realize the fixation of the blood storage device 200.

[0095] In some embodiments, an arterial pressure sensor 332 is arranged on the output pipeline 331, a venous pressure sensor 211 is arranged on the input pipeline 210, a flow sensor 440 is arranged on the pipeline downstream of the pump drive assembly 400, a temperature sensor is arranged on the heater 320 or the pipeline downstream of the heater 320, and the blood storage device 200 is provided with a liquid level sensor 220, and the like. The above-mentioned sensors are in communication connection with the control host 100, so that the control host 100 can use filtering and anti-shake algorithms and combine with clinical data to develop intelligent control algorithms based on the physiological parameters and perfusion parameters collected by the sensors in real time, to evaluate the organ perfusion condition in real time and calculate the optimal intervention measures, to control the pump speed to realize the automatic adjustment of the flow and pressure, and to ensure that the blood level in the blood storage device 200 is always in a safe position, thereby avoiding safety accidents caused by blood emptying.

[0096] In summary, the present application proposes a combined donor perfusion device, which assembles various devices on the trolley 500, is convenient to use and flexible to operate, can monitor the perfusion state in real time and perform intelligent adjustment. Through the real-time collection of the physiological parameters of blood and the working parameters of perfusion by various sensors such as temperature sensors, flow rate sensors and pressure sensors, the perfusion condition of the donor is evaluated and the optimal intervention measures are calculated, the pump speed is controlled to realize the automatic adjustment of the flow and pressure, or an alarm is triggered to remind the operating personnel to manually intervene, thereby realizing the man-machine interaction function.

[0097] The second aspect embodiment of the present application further proposes a donor perfusion device use method, which can be applied to the donor perfusion device mentioned in any of the above embodiments. The use method comprises the following steps:

[0098] S100, installing consumables;

[0099] Based on the foregoing, in the present application, the blood reservoir 200, the pipeline for circulating blood, etc. are all disposable consumables, which need to be replaced after use to prevent cross infection.

[0100] S200, turn on the control host 100 switch, program self-checking;

[0101] In this step, the control host 100 energizes each sensor and detects whether each sensor can operate normally.

[0102] S300, supplement the pre-charging liquid into the blood reservoir 200, and switch the donor perfusion device to the self-circulation mode;

[0103] In this step, the air in each pipeline needs to be discharged through the self-circulation pre-charging liquid. It should be noted that in the self-circulation mode, the output pipeline 331 and the input pipeline 210 are in communication, for example, the output pipeline 331 and the input pipeline 210 are integrally formed pipelines, which maintain an integrally through structure in the self-circulation mode, so that the pre-charging liquid can flow through the input pipeline 210 from the output pipeline 331 and then return to the blood reservoir 200, or the output pipeline 331 and the input pipeline 210 are independent pipelines which are connected to a through structure in the self-circulation mode.

[0104] S400, supplement the blood into the blood reservoir 200, and make the donor perfusion device enter the external circulation mode;

[0105] The step further includes the following steps: first, if the output pipeline 331 and the input pipeline 210 are integrally formed pipelines, they need to be cut off in this step to form the output pipeline 331 and the input pipeline 210 respectively, and the input pipeline 210 can be connected to the donor's venous blood vessel to enable the blood flowing out of the donor to be collected by the blood reservoir 200. The donor perfusion device uses blood to circulate and gradually discharges the pre-charging liquid through the output pipeline 331, and after the blood is discharged from the output pipeline 331, the output pipeline 331 is closed by the pipeline clamp and the circulation pipeline 333 is opened to make the blood stop flowing out of the output pipeline 331, then the connection between the output pipeline 331 and the donor's arterial blood vessel is realized, after the connection is completed, the output pipeline 331 is opened and the circulation pipeline 333 is closed to make the donor perfusion device enter the external circulation mode, and the blood of the donor can be oxygenated, heated, filtered and circulated through the donor perfusion device to maintain the activity of the donor.

[0106] The embodiments of the present application are described in detail above in combination with the drawings, but the present application is not limited to the above-mentioned embodiments, and various changes can be made within the knowledge range of ordinary skilled persons in the art without departing from the purpose of the present application. In addition, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

Claims

1. A donor perfusion device, characterized in that, The application relates to a donor perfusion device, comprising: a control host; a blood storage device for receiving blood input by a donor; a processing assembly, through which the blood is output to the donor; a pump driving assembly in communication with the blood storage device and the processing assembly respectively, for driving the blood to flow through the processing assembly and then be output, the pump driving assembly comprising a first pump body and a second pump body, which are respectively in communication connection with the control host; wherein the pump driving assembly has a first working condition and a second working condition, in the first working condition, the control host controls the first pump body to work, and in the second working condition, the control host controls the second pump body to work; the pump driving assembly comprises a first pump head which can be detachably connected with any one of the first pump body and the second pump body, the first pump body and the second pump body can both drive the first pump head to work, the first pump head is in communication with the blood storage device and the processing assembly respectively, in the first working condition, the first pump head is connected with the first pump body, and in the second working condition, the first pump head is connected with the second pump body; the donor perfusion device comprises an input pipeline in communication with the blood storage device and an output pipeline in communication with the processing assembly, the output pipeline is used for being in communication with the donor; wherein the donor perfusion device further comprises a circulation pipeline, one end of the circulation pipeline is in communication with the blood storage device, and the other end is in communication with the processing assembly, when the output pipeline and the input pipeline are ready to be in communication with the donor, at least the output pipeline is closed, the circulation pipeline is opened, and after the output pipeline is in communication with the donor, the circulation pipeline is closed.

2. A donor perfusion device, characterized by The application relates to a donor perfusion device, comprising: a control host; a blood storage device for receiving blood input by a donor; a processing assembly, through which the blood is output to the donor; a pump driving assembly in communication with the blood storage device and the processing assembly respectively, for driving the blood to flow through the processing assembly and then be output, the pump driving assembly comprising a first pump body and a second pump body, which are respectively in communication connection with the control host; wherein the pump driving assembly has a first working condition and a second working condition, in the first working condition, the control host controls the first pump body to work, and in the second working condition, the control host controls the second pump body to work; the pump driving assembly comprises a first pump head which can be detachably connected with any one of the first pump body and the second pump body, the first pump body and the second pump body can both drive the first pump head to work, the first pump head is in communication with the blood storage device and the processing assembly respectively, in the first working condition, the first pump head is connected with the first pump body, and in the second working condition, the first pump head is connected with the second pump body; the donor perfusion device comprises an input pipeline in communication with the blood storage device and an output pipeline in communication with the processing assembly, the output pipeline is used for being in communication with the donor; wherein the donor perfusion device further comprises a circulation pipeline, one end of the circulation pipeline is in communication with the blood storage device, and the other end is in communication with the processing assembly, when the output pipeline and the input pipeline are ready to be in communication with the donor, at least the output pipeline is closed, the circulation pipeline is opened, and after the output pipeline is in communication with the donor, the circulation pipeline is closed. The donor perfusion device further comprises a circulation pipeline, one end of the circulation pipeline is communicated with the blood storage device, and the other end is communicated with the processing assembly, when the output pipeline and the input pipeline are ready to be communicated with the donor, at least the output pipeline is closed, and the circulation pipeline is opened, and after the output pipeline is communicated with the donor, the circulation pipeline is closed.

3. The donor perfusion device of claim 1 or 2, wherein, The donor perfusion device comprises an output pipeline, one end of the output pipeline is communicated with the processing assembly, and the other end is used to be communicated with the donor, the output pipeline is provided with a sensor in communication connection with the control host, the control host acquires physiological parameters collected by the sensor, and if the physiological parameters are out of the set range, the control host controls the pump driving assembly to switch from the first working condition to the second working condition. Alternatively, the control host acquires working parameters of the first pump body, and if the working parameters are out of the set range, the control host controls the pump driving assembly to switch from the first working condition to the second working condition.

4. The donor perfusion device of claim 1 or 2, wherein, After the control host switches from the first working condition to the second working condition, the current working condition is set as the first working condition, the second pump body is set as a new first pump body, and the first pump body is set as a new second pump body.

5. The donor perfusion device of claim 2, wherein, The pump driving assembly further comprises an input three-way valve and an output three-way valve, each port of the input three-way valve is communicated with the blood storage device, the input port of the first pump head and the input port of the second pump head respectively, and each port of the output three-way valve is communicated with the processing assembly, the output port of the first pump head and the output port of the second pump head respectively. The input three-way valve and the output three-way valve are respectively in communication connection with the control host and are controlled to switch the on-off state by the control host, in the first working condition, the blood storage device, the input port of the first pump head, the output port of the first pump head and the processing assembly are communicated in turn, and in the second working condition, the blood storage device, the input port of the second pump head, the output port of the second pump head and the processing assembly are communicated in turn.

6. The donor perfusion device of claim 2, wherein, The donor perfusion device comprises an input pipeline communicated with the blood storage device and an output pipeline communicated with the processing assembly, the donor perfusion device comprises a self-circulation mode and an external circulation mode, in the self-circulation mode, the input pipeline and the output pipeline are communicated, and in the external circulation mode, the input pipeline is used to be communicated with the donor, and the output pipeline is used to be communicated with the donor. The donor perfusion device switches to the external circulation mode after setting time in the self-circulation mode, wherein in the self-circulation mode, the control host controls the pump driving assembly to switch at least once.

7. The donor perfusion device of claim 1 or 2, wherein, The donor perfusion device further comprises a trolley, the trolley is provided with a mounting table, the mounting table is provided with a clamping assembly, and opposite side walls of the control host are respectively provided with clamping grooves, when the control host is placed on the mounting table, the clamping assembly is clamped with the clamping grooves.

8. The donor perfusion device of claim 7, wherein, The mounting table comprises a first shell and a second shell, which define a transmission cavity, and further comprises a clamping piece, an elastic piece, an adapter and a button movably connected with the first shell, the elastic piece is connected with the clamping piece, and the clamping piece and the adapter are movably connected with the second shell respectively; The clamping piece has a first state of partially protruding from the first shell under the driving of the elastic piece, in which state, the protruding part of the clamping piece can be embedded in the clamping groove to limit the movement of the control host; and the clamping piece also has a second state of being withdrawn into the first shell under the driving of the adapter, in which state, the clamping piece is located outside the clamping groove, and the control host can be separated from the mounting table; the button is configured to drive the adapter to rotate when pressed, so as to drive the clamping piece to switch from the first state to the second state.

9. The donor perfusion device of claim 7, wherein, The trolley is further provided with a mounting rod and a mounting bracket arranged on the mounting rod, the mounting bracket comprises a first body part sleeved on the mounting rod, a second body part movably connected with the first body part, a first locking part mounted on the first body part, and a second locking part mounted on the first body part or the second body part, the first locking part is configured to movably connect the first body part with the mounting rod when loosened, and fix the first body part and the mounting rod when tightened; the second locking part is configured to movably connect the second body part with the first body part when loosened, and fix the first body part and the second body part when tightened.

10. A method of using a donor perfusion device according to any one of claims 1 to 9, wherein, The method comprises the following steps: installing consumables; turning on the control host switch and performing self-checking; adding pre-charged liquid into the blood storage device to switch the donor perfusion device to the self-circulation mode; adding blood into the blood storage device to make the donor perfusion device enter the external circulation mode.

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