Composite carnosine composition and preparation method thereof

Abstract

The invention belongs to the field of daily chemicals, and discloses a compound carnosine composition and a preparation method thereof. The compound carnosine composition disclosed by the invention is prepared from L-carnosine zinc, N-acetyl-L-carnosine, L-carnosine, propolis extract, citrus peel extract, potato pulp extract, resveratrol, white willow bark extract, pomelo seed extract, polypropylene glycol, carboxymethyl chitosan, allantoin, brown algae extract, oat alkaloid, tripeptide-1 copper, xanthan gum and glycerol. The compound carnosine composition comprises zinc L-carnosine, N-acetyl-L-carnosine, L-carnosine, resveratrol and the like, carnosine and derivatives of carnosine are fully utilized, and a new choice is provided for freckle removing and whitening products.

Description

Technical Field

[0001] The invention relates to the field of daily chemicals, and in particular to a composite carnosine composition and a preparation method thereof. Background Art

[0002] L-Carnosine (CAS: 305-84-0, Carnosine) was first detected in beef by Russian scientists Gulewitsh and Amiradzibi in 1900. It is widely present in the brain, muscles and other nerve-distributed tissues of mammals. The concentration in animals is about 1-20mmol / L. Its chemical name is: β-alanyl-L-histidine, which is a natural dipeptide condensed from β-alanine and L-histidine. Studies have shown that L-carnosine has important physiological and pharmacological functions such as anti-oxidation, anti-aging, scavenging free radicals in the body, chelating transition metals, and preventing ulcers. It has certain effects on a variety of diseases such as hypertension, heart disease, Alzheimer's disease, cataracts, and anti-tumor.

[0003] L-carnosine also has a very wide range of applications in the fields of health care, food and beauty. For example, Chinese patent application CN111956585 provides a carnosine freckle removal liquid, the raw materials of which include: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, dipeptide diaminobutyryl benzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps sinensis extract, sea angelica leaf / stem extract, Centella asiatica leaf extract, purple magnolia flower extract, oat alkaloids, carnosine, propolis extract, aloe vera extract, allantoin, xanthan gum, citrus peel extract, brown algae extract, caprylhydroxamic acid, sodium hyaluronate, sodium ascorbate, white willow bark extract and grapefruit seed extract. The freckle removal liquid prepared by the reasonable proportion of the above components and a simple and efficient preparation method has good freckle removal effect and can also play a good moisturizing role while removing freckles. However, the ingredients of this freckle removal liquid are complex, the amount of carnosine used is relatively low, and the beauty effects of carnosine are not fully and effectively utilized. Summary of the invention

[0004] In order to overcome the shortcomings of the above-mentioned background technology, the present invention provides a composite carnosine composition and a preparation method thereof. The composite carnosine composition comprises ingredients such as L-carnosine zinc, N-acetyl-L-carnosine, L-carnosine and resveratrol, and makes full use of carnosine and its derivatives, providing a new choice for freckle removal and whitening products.

[0005] To achieve the purpose of the present invention, the composite carnosine composition of the present invention comprises L-carnosine zinc, N-acetyl-L-carnosine, L-carnosine, propolis extract, citrus peel extract, potato pulp extract, resveratrol, white willow bark extract, grapefruit seed extract, polypropylene glycol, carboxymethyl deacetylated chitosan, allantoin, brown algae extract, oat alkaloids, tripeptide-1 copper, xanthan gum, glycerin, butylene glycol, caprylhydroxamic acid, sodium ascorbate, and water.

[0006] L-carnosine zinc, as one of the substances in the nutritional supplements, can not only be used to treat ulcers and help wound healing, but also to protect gastric mucosa and reduce gastrointestinal damage. It has been widely used in clinical medicine, but rarely used in the field of cosmetics. Chinese patent CN116421494B found that the combined use of carnosine zinc and glutathione zinc has excellent whitening and anti-aging effects, and is safe and non-irritating to the skin.

[0007] The English name of N-Acetyl-L-Carnosine is N-Acetyl-L-Carnosine, and its chemical name is Acetyl-β-Alanyl-Histidine. It has ideal effects in removing wrinkles, preventing aging and repairing skin damage, and has no toxic side effects.

[0008] Resveratrol has strong antioxidant activity, can neutralize free radicals, reduce damage caused by oxidative stress, and can stimulate the synthesis of collagen in skin cells, increase skin elasticity and firmness, help reduce wrinkle formation, and improve skin texture. Resveratrol can also interfere with the activity of tyrosinase, thereby reducing the production of melanin, which is very beneficial for improving skin pigmentation, freckles and uneven pigmentation. In addition, the antioxidant capacity of resveratrol can greatly reduce the phenomenon of pigmentation, making the skin more even and brighter.

[0009] Further, in some embodiments of the present invention, the composite carnosine composition comprises, by weight: 2-4 parts of L-carnosine zinc, 6-10 parts of N-acetyl-L-carnosine, 6-10 parts of L-carnosine, 5-8 parts of propolis extract, 2-4 parts of citrus peel extract, 2-5 parts of potato pulp extract, 2-3 parts of resveratrol, 0.6-1.2 parts of white willow bark extract, 0.8-1.6 parts of grapefruit seed extract, 2-6 parts of polypropylene glycol, 3-5 parts of carboxymethyl deacetylated chitosan, 2-3 parts of allantoin, 1-2 parts of brown algae extract, 1-4 parts of oat alkaloids, 1-3 parts of tripeptide-1 copper, 1-2 parts of xanthan gum, 2-4 parts of glycerol, 1-2 parts of butylene glycol, 0.5-1.5 parts of caprylhydroxamic acid, 0.5-1 parts of sodium ascorbate, and 35-55 parts of water.

[0010] Furthermore, the present invention also provides a method for preparing the aforementioned composite carnosine composition, the preparation method comprising the following steps:

[0011] (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating them to completely dissolve them to obtain a mixture A;

[0012] (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, L-carnosine zinc, N-acetyl-L-carnosine and L-carnosine to obtain a mixture B, adding the mixture A to the mixture B, and stirring while keeping warm to obtain a mixture C;

[0013] (3) cooling the mixture C, adding citrus peel extract, sodium ascorbate, resveratrol, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring to obtain a mixture D;

[0014] (4) Add octanoylhydroxamic acid to the mixture D, stir, cool, and filter to obtain the product.

[0015] Furthermore, in some embodiments of the present invention, the temperature is increased in step (1) to 70-80°C.

[0016] Furthermore, in some embodiments of the present invention, the insulation in step (2) is to maintain the temperature at 75-80°C.

[0017] Furthermore, in some embodiments of the present invention, the insulation time in step (2) is 15-25 minutes.

[0018] Furthermore, in some embodiments of the present invention, the cooling in step (3) is to 40-45°C.

[0019] Furthermore, in some embodiments of the present invention, the cooling in step (4) is cooling to below 40°C.

[0020] Furthermore, in some embodiments of the present invention, the stirring speed in steps (1)-(4) is 100-400 rpm.

[0021] Furthermore, in some embodiments of the present invention, the stirring time in steps (3)-(4) is 15-20 min.

[0022] Furthermore, the present invention also provides a cosmetic comprising the composite carnosine composition of the present invention, wherein the cosmetic is a facial mask, a lotion, a whitening and anti-freckle cream, a moisturizer, an anti-freckle liquid, and the like.

[0023] Dipeptide diaminobutyryl benzylamide diacetate (snake venom peptide) can promote skin metabolism and improve skin condition when used appropriately. However, long-term use may affect skin health and may cause skin sagging, allergies and other adverse reactions. Compared with the prior art, the composite carnosine composition of the present invention does not contain snake venom peptide, as well as substances such as Aloe vera extract, Cordyceps sinensis extract, Littoral Angelica leaf / stem extract, Centella asiatica leaf extract, and Magnolia officinalis extract. The composition is relatively simple. By adding L-carnosine zinc, N-acetyl-L-carnosine, L-carnosine and other carnosine substances and resveratrol and other ingredients, the synergistic effect produces a significant effect on the inhibition of tyrosinase, which can play a role in expelling spots without damaging the skin. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with embodiments. Additional aspects and advantages of the present invention will be given in part in the following description, and part will become apparent from the following description, or will be understood through the practice of the present invention. It should be understood that the following description is only used to explain the present invention and is not intended to limit the present invention.

[0025] As used herein, the terms "comprises," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

[0026] When amount, concentration or other value or parameter is expressed as range, preferred range or a series of upper preferred value and lower preferred value limit range, this should be understood as specifically disclosing all ranges formed by any pairing of any range upper limit or preferred value and any range lower limit or preferred value, regardless of whether the range is disclosed separately. For example, when disclosing range "1 to 5", described range should be interpreted as including range "1 to 4", "1 to 3", "1 to 2", "1 to 2 and 4 to 5", "1 to 3 and 5" etc. When numerical range is described in this article, unless otherwise stated, the range is intended to include its end value and all integers and fractions within the range.

[0027] Singular forms include plural references unless the context clearly indicates otherwise. "Optional" or "either" means that the subsequently described event or incident may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

[0028] The indefinite articles "a" and "an" before the elements or components of the present invention have no limitation on the quantity requirements (i.e. the number of occurrences) of the elements or components. Therefore, "a" or "an" should be interpreted as including one or at least one, and the elements or components in the singular form also include the plural form, unless the quantity obviously refers to the singular form only.

[0029] In the specific embodiment of the present invention, the stirring speed is 100-400 rpm, and the fluctuation of the stirring speed will not have a substantial effect on the properties of the composite carnosine composition of the present invention.

[0030] Example 1

[0031] A composite carnosine composition comprises, by weight: 4 parts of L-carnosine zinc, 10 parts of N-acetyl-L-carnosine, 10 parts of L-carnosine, 8 parts of propolis extract, 4 parts of citrus peel extract, 5 parts of potato pulp extract, 3 parts of resveratrol, 1.2 parts of white willow bark extract, 1.6 parts of grapefruit seed extract, 6 parts of polypropylene glycol, 5 parts of carboxymethyl deacetylated chitosan, 3 parts of allantoin, 2 parts of brown algae extract, 4 parts of oat alkaloids, 3 parts of tripeptide-1 copper, 2 parts of xanthan gum, 4 parts of glycerol, 2 parts of butylene glycol, 1.5 parts of caprylhydroxamic acid, 1 part of sodium ascorbate and 55 parts of water.

[0032] The preparation method of the above-mentioned composite carnosine composition comprises the following steps:

[0033] (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating to 80° C. to completely dissolve them, to obtain a mixture A;

[0034] (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, L-carnosine zinc, N-acetyl-L-carnosine and L-carnosine to obtain a mixture B, adding the mixture A to the mixture B, maintaining the temperature at 80° C. and stirring for 20 min to obtain a mixture C;

[0035] (3) cooling the mixture C to 45° C., adding citrus peel extract, sodium ascorbate, resveratrol, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring for 20 minutes to obtain a mixture D;

[0036] (4) Add octanoylhydroxamic acid to the mixture D, stir for 20 min, cool to below 40° C., and filter to obtain the product.

[0037] Example 2

[0038] A composite carnosine composition comprises, by weight: 2 parts of L-carnosine zinc, 6 parts of N-acetyl-L-carnosine, 6 parts of L-carnosine, 5 parts of propolis extract, 2 parts of citrus peel extract, 2 parts of potato pulp extract, 2 parts of resveratrol, 0.6 parts of white willow bark extract, 0.8 parts of grapefruit seed extract, 2 parts of polypropylene glycol, 3 parts of carboxymethyl deacetylated chitosan, 2 parts of allantoin, 1 part of brown algae extract, 1 part of oat alkaloids, 1 part of tripeptide-1 copper, 1 part of xanthan gum, 2 parts of glycerol, 1 part of butylene glycol, 0.5 parts of caprylhydroxamic acid, 0.5 parts of sodium ascorbate and 38 parts of water.

[0039] The preparation method of the above-mentioned composite carnosine composition comprises the following steps:

[0040] (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating to 72° C. to completely dissolve them, to obtain a mixture A;

[0041] (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, L-carnosine zinc, N-acetyl-L-carnosine and L-carnosine to obtain a mixture B, adding the mixture A to the mixture B, maintaining the temperature at 75° C. and stirring for 15 minutes to obtain a mixture C;

[0042] (3) cooling the mixture C to 41° C., adding citrus peel extract, sodium ascorbate, resveratrol, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring for 15 minutes to obtain a mixture D;

[0043] (4) Add octanoyl hydroxamic acid to the mixture D, stir for 16 min, cool to below 40° C., and filter to obtain the product.

[0044] Example 3

[0045] A composite carnosine composition comprises, by weight: 3 parts of L-carnosine zinc, 8 parts of N-acetyl-L-carnosine, 8 parts of L-carnosine, 6 parts of propolis extract, 3 parts of citrus peel extract, 4 parts of potato pulp extract, 2.5 parts of resveratrol, 0.9 parts of white willow bark extract, 1.2 parts of grapefruit seed extract, 4 parts of polypropylene glycol, 4 parts of carboxymethyl deacetylated chitosan, 2.5 parts of allantoin, 1.5 parts of brown algae extract, 3 parts of oat alkaloids, 1.5 parts of tripeptide-1 copper, 1.5 parts of xanthan gum, 3 parts of glycerol, 1.5 parts of butylene glycol, 1.0 parts of caprylhydroxamic acid, 0.8 parts of sodium ascorbate and 45 parts of water.

[0046] The preparation method of the above-mentioned composite carnosine composition comprises the following steps:

[0047] (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating to 75° C. to completely dissolve them, to obtain a mixture A;

[0048] (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, L-carnosine zinc, N-acetyl-L-carnosine and L-carnosine to obtain a mixture B, adding the mixture A to the mixture B, maintaining the temperature at 78° C. and stirring for 16 minutes to obtain a mixture C;

[0049] (3) cooling the mixture C to 40° C., adding citrus peel extract, sodium ascorbate, resveratrol, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring for 18 minutes to obtain a mixture D;

[0050] (4) Add octanoylhydroxamic acid to the mixture D, stir for 20 min, cool to below 40° C., and filter to obtain the product.

[0051] Example 4

[0052] A composite carnosine composition comprises, by weight: 8 parts of N-acetyl-L-carnosine, 8 parts of L-carnosine, 6 parts of propolis extract, 3 parts of citrus peel extract, 4 parts of potato pulp extract, 2.5 parts of resveratrol, 0.9 parts of white willow bark extract, 1.2 parts of grapefruit seed extract, 4 parts of polypropylene glycol, 4 parts of carboxymethyl deacetylated chitosan, 2.5 parts of allantoin, 1.5 parts of brown algae extract, 3 parts of oat alkaloids, 1.5 parts of tripeptide-1 copper, 1.5 parts of xanthan gum, 3 parts of glycerol, 1.5 parts of butylene glycol, 1.0 parts of caprylhydroxamic acid, 0.8 parts of sodium ascorbate and 45 parts of water.

[0053] The preparation method of the above-mentioned composite carnosine composition comprises the following steps:

[0054] (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating to 75° C. to completely dissolve them, to obtain a mixture A;

[0055] (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, N-acetyl-L-carnosine and L-carnosine to obtain mixture B, adding mixture A to mixture B, maintaining the temperature at 78° C. and stirring for 16 minutes to obtain mixture C;

[0056] (3) cooling the mixture C to 40° C., adding citrus peel extract, sodium ascorbate, resveratrol, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring for 18 minutes to obtain a mixture D;

[0057] (4) Add octanoylhydroxamic acid to the mixture D, stir for 20 min, cool to below 40° C., and filter to obtain the product.

[0058] Example 5

[0059] A composite carnosine composition comprises, by weight: 3 parts of L-carnosine zinc, 8 parts of L-carnosine, 6 parts of propolis extract, 3 parts of citrus peel extract, 4 parts of potato pulp extract, 2.5 parts of resveratrol, 0.9 parts of white willow bark extract, 1.2 parts of grapefruit seed extract, 4 parts of polypropylene glycol, 4 parts of carboxymethyl deacetylated chitosan, 2.5 parts of allantoin, 1.5 parts of brown algae extract, 3 parts of oat alkaloids, 1.5 parts of tripeptide-1 copper, 1.5 parts of xanthan gum, 3 parts of glycerol, 1.5 parts of butylene glycol, 1.0 parts of caprylhydroxamic acid, 0.8 parts of sodium ascorbate and 45 parts of water.

[0060] The preparation method of the above-mentioned composite carnosine composition comprises the following steps:

[0061] (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating to 75° C. to completely dissolve them, to obtain a mixture A;

[0062] (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, L-carnosine zinc and L-carnosine to obtain mixture B, adding mixture A to mixture B, maintaining the temperature at 78° C. and stirring for 16 minutes to obtain mixture C;

[0063] (3) cooling the mixture C to 40° C., adding citrus peel extract, sodium ascorbate, resveratrol, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring for 18 minutes to obtain a mixture D;

[0064] (4) Add octanoylhydroxamic acid to the mixture D, stir for 20 min, cool to below 40° C., and filter to obtain the product.

[0065] Example 6

[0066] A composite carnosine composition comprises, by weight: 3 parts of L-carnosine zinc, 8 parts of N-acetyl-L-carnosine, 3 parts of L-carnosine, 6 parts of propolis extract, 3 parts of citrus peel extract, 4 parts of potato pulp extract, 2.5 parts of resveratrol, 0.9 parts of white willow bark extract, 1.2 parts of grapefruit seed extract, 4 parts of polypropylene glycol, 4 parts of carboxymethyl deacetylated chitosan, 2.5 parts of allantoin, 1.5 parts of brown algae extract, 3 parts of oat alkaloids, 1.5 parts of tripeptide-1 copper, 1.5 parts of xanthan gum, 3 parts of glycerol, 1.5 parts of butylene glycol, 1.0 parts of caprylhydroxamic acid, 0.8 parts of sodium ascorbate and 45 parts of water.

[0067] The preparation method of the above-mentioned composite carnosine composition comprises the following steps:

[0068] (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating to 75° C. to completely dissolve them, to obtain a mixture A;

[0069] (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, L-carnosine zinc, N-acetyl-L-carnosine and L-carnosine to obtain a mixture B, adding the mixture A to the mixture B, maintaining the temperature at 78° C. and stirring for 16 minutes to obtain a mixture C;

[0070] (3) cooling the mixture C to 40° C., adding citrus peel extract, sodium ascorbate, resveratrol, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring for 18 minutes to obtain a mixture D;

[0071] (4) Add octanoylhydroxamic acid to the mixture D, stir for 20 min, cool to below 40° C., and filter to obtain the product.

[0072] Example 7

[0073] A composite carnosine composition comprises, by weight: 3 parts of L-carnosine zinc, 8 parts of N-acetyl-L-carnosine, 8 parts of L-carnosine, 6 parts of propolis extract, 3 parts of citrus peel extract, 4 parts of potato pulp extract, 0.9 parts of white willow bark extract, 1.2 parts of grapefruit seed extract, 4 parts of polypropylene glycol, 4 parts of carboxymethyl deacetylated chitosan, 2.5 parts of allantoin, 1.5 parts of brown algae extract, 3 parts of oat alkaloids, 1.5 parts of tripeptide-1 copper, 1.5 parts of xanthan gum, 3 parts of glycerol, 1.5 parts of butylene glycol, 1.0 parts of caprylhydroxamic acid, 0.8 parts of sodium ascorbate and 45 parts of water.

[0074] The preparation method of the above-mentioned composite carnosine composition comprises the following steps:

[0075] (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating to 75° C. to completely dissolve them, to obtain a mixture A;

[0076] (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, L-carnosine zinc, N-acetyl-L-carnosine and L-carnosine to obtain a mixture B, adding the mixture A to the mixture B, maintaining the temperature at 78° C. and stirring for 16 minutes to obtain a mixture C;

[0077] (3) cooling the mixture C to 40° C., adding citrus peel extract, sodium ascorbate, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring for 18 minutes to obtain a mixture D;

[0078] (4) Add octanoylhydroxamic acid to the mixture D, stir for 20 min, cool to below 40° C., and filter to obtain the product.

[0079] In vitro tyrosinase inhibition assay

[0080] Test sample: the compound carnosine composition prepared in Examples 1-7.

[0081] The test method was carried out with reference to Chinese patent application CN111956585: 1 mL sodium phosphate buffer (1 / 15 mol / L, pH=6.8), 0.5 mL test sample, and 1 mL tyrosinase solution (tyrosinase was prepared into a 100 U / mL solution using phosphate buffer solution) were added to the test tube in sequence, and the mixture was placed in a 30°C water bath for 10 min. After the addition of 2.5 mL L-tyrosine solution (mass fraction was 0.05%), the time was immediately started, and the absorbance value B at 475 nm was measured after 20 min of reaction. The absorbance value A when 0.5 mL test sample was not added was measured in the same way. The inhibition rate = {(AB) / A}×100%, wherein A is the absorbance value when the test sample is not added, and B is the absorbance value of the test sample. Three parallel tests were performed on each group of test samples, and the results are shown in Table 1.

[0082] Table 1 Results of in vitro tyrosinase inhibition test of the composite carnosine compositions of various embodiments

[0083]

[0084]

[0085] It will be easily understood by those skilled in the art that the above description is merely an example of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A composite carnosine composition, characterized in that: The composite carnosine composition comprises L-carnosine zinc, N-acetyl-L-carnosine, L-carnosine, propolis extract, citrus peel extract, potato pulp extract, resveratrol, white willow bark extract, grapefruit seed extract, polypropylene glycol, carboxymethyl deacetylated chitosan, allantoin, brown algae extract, oat alkaloids, tripeptide-1 copper, xanthan gum, glycerin, butylene glycol, caprylhydroxamic acid, sodium ascorbate and water.

2. The composite carnosine composition according to claim 1, characterized in that The composite carnosine composition comprises, by weight: 2-4 parts of L-carnosine zinc, 6-10 parts of N-acetyl-L-carnosine, 6-10 parts of L-carnosine, 5-8 parts of propolis extract, 2-4 parts of citrus peel extract, 2-5 parts of potato pulp extract, 2-3 parts of resveratrol, 0.6-1.2 parts of white willow bark extract, 0.8-1.6 parts of grapefruit seed extract, 2-6 parts of polypropylene glycol, 3-5 parts of carboxymethyl deacetylated chitosan, 2-3 parts of allantoin, 1-2 parts of brown algae extract, 1-4 parts of oat alkaloids, 1-3 parts of tripeptide-1 copper, 1-2 parts of xanthan gum, 2-4 parts of glycerol, 1-2 parts of butylene glycol, 0.5-1.5 parts of caprylhydroxamic acid, 0.5-1 parts of sodium ascorbate and 35-55 parts of water.

3. The method for preparing the composite carnosine composition according to any one of claims 1 to 2, characterized in that: The preparation method comprises the following steps: (1) uniformly stirring water, glycerin, butylene glycol, carboxymethyl chitosan, propolis extract, allantoin and xanthan gum, and heating them to completely dissolve them to obtain a mixture A; (2) mixing tripeptide-1 copper, potato pulp extract, oat alkaloids, polypropylene glycol, L-carnosine zinc, N-acetyl-L-carnosine and L-carnosine to obtain a mixture B, adding the mixture A to the mixture B, and stirring while keeping warm to obtain a mixture C; (3) cooling the mixture C, adding citrus peel extract, sodium ascorbate, resveratrol, white willow bark extract, grapefruit seed extract and brown algae extract, and stirring to obtain a mixture D; (4) Add octanoylhydroxamic acid to the mixture D, stir, cool, and filter to obtain the product.

4. The method for preparing the composite carnosine composition according to claim 3, wherein: The temperature in step (1) is raised to 70-80°C.

5. The method for preparing the composite carnosine composition according to claim 3, wherein: The insulation in step (2) is to maintain the temperature at 75-80° C.; preferably, the insulation time in step (2) is 15-25 minutes.

6. The method for preparing the composite carnosine composition according to claim 3, characterized in that: The cooling in step (3) is to cool to 40-45°C.

7. The method for preparing the composite carnosine composition according to claim 3, characterized in that: The cooling in step (4) is to a temperature below 40°C.

8. The method for preparing the composite carnosine composition according to claim 3, characterized in that: The stirring speed in steps (1) to (4) is 100-400 rpm.

9. The method for preparing the composite carnosine composition according to claim 3, characterized in that: The stirring time in steps (3)-(4) is 15-20 minutes.

10. A cosmetic comprising the composite carnosine composition according to any one of claims 1 to 2, characterized in that: The cosmetics are facial masks, lotions, whitening and anti-freckle creams, moisturizing creams, and anti-freckle liquids.

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