Composition with relieving and barrier repairing functions and application thereof

Abstract

The invention provides a composition with relieving and barrier repairing functions and application thereof. The composition with relieving and barrier repairing functions is prepared from the following components in parts by weight: 5 to 40 parts of glycosylglycerol and 10 to 70 parts of lactobacillus / algae extract fermentation product. The invention creatively finds that the composition composed of the glycosylglycerol and the lactobacillus / algae extract fermentation product can repair the skin barrier and has remarkable effects in the aspects of relieving, repairing and oxidation resistance, and the glycosylglycerol and the lactobacillus / algae extract fermentation product have a synergistic effect on the effects; the skin care lotion prepared by the method has excellent effects of moisturizing, tightening skin, enhancing elasticity, removing redness and blackness, whitening and brightening.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a composition with soothing and barrier repairing functions and application thereof. Background Art

[0002] The skin barrier is the first line of defense for the human body against external stimuli, and its integrity is crucial to maintaining the normal state of the skin. However, many factors continue to affect the function of the skin barrier, making skin soothing and barrier repair a core demand in the field of skin care.

[0003] On the one hand, ultraviolet radiation in the external environment is becoming increasingly serious. Long-term exposure to ultraviolet rays will not only cause sunburn and tanning of the skin, but also cause photoaging of the skin, destroying the collagen fibers and elastic fibers of the skin, making the skin loose and rough. More importantly, after ultraviolet rays penetrate the surface of the skin, they will directly damage the DNA of skin cells, interfere with the normal metabolism of cells, and thus weaken the skin barrier function. On the other hand, improper cleaning, certain irritating ingredients in cosmetics, and life stress will cause stress reactions in the skin, resulting in sensitive symptoms such as redness, itching, dryness, and desquamation, causing varying degrees of damage to the skin barrier.

[0004] CN116035991A discloses a plant extract composition and cosmetics with anti-allergic and soothing effects, wherein the plant extract composition comprises Imperata root extract, Ophiopogon extract and Portulaca oleracea extract. Imperata root extract as an active ingredient can alleviate skin inflammation and desquamation, reduce scratching, relieve abnormal thickening of the epidermis, and reduce the number of skin mast cells, and can be widely used in soothing and anti-allergic skin care products. Imperata root can play a certain anti-inflammatory and soothing effect on skin irritation when used alone, and can improve the anti-inflammatory effect when used in combination with Ophiopogon extract and Portulaca oleracea extract having similar effects.

[0005] CN115252465A discloses an oil-controlling and soothing skin care composition, cosmetics, preparation method and application thereof, wherein the oil-controlling and soothing skin care composition comprises the following components by weight: 0.1-1.0 parts of zinc hyaluronate, 1.0-20 parts of wild sunflower fruit extract, and 1.0-20 parts of peucedanum peucedanum extract. The composition achieves oil-control effect by inhibiting the activity of 5α-reductase and COX2 factor through multi-pathway action, and also achieves soothing effect by inhibiting the activity of IL-1α, TNF-a and PGE2 factor.

[0006] CN115089521A discloses a soothing and anti-inflammatory composition, a soothing and anti-inflammatory cosmetic and a preparation method thereof. The soothing and anti-inflammatory composition comprises sodium carboxymethyl β-glucan, purslane extract, Centella asiatica extract, sea fennel extract and panthenol. By using these five ingredients in combination, their respective effects can be effectively exerted, skin sensitivity can be alleviated from multiple dimensions, and sensitive skin can be effectively soothed. At the same time, they can also be added as functional components into soothing and anti-inflammatory cosmetics, and the obtained soothing and anti-inflammatory cosmetics also show excellent skin repair ability.

[0007] There are many existing cosmetic products that claim to have soothing and anti-inflammatory effects, but there are very few that can truly penetrate deep into the skin to repair sensitive skin. Based on this, it is of great significance to develop a composition with soothing and barrier repair functions. Summary of the invention

[0008] In view of the deficiencies in the prior art, the object of the present invention is to provide a composition with soothing and barrier repair functions and its application. The composition provided by the present invention has soothing, repairing and antioxidant properties, and the cosmetics prepared therefrom have excellent barrier repair, hydrating and moisturizing, enhancing skin elasticity, and whitening and brightening effects.

[0009] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0010] In a first aspect, the present invention provides a composition with soothing and barrier repairing functions, wherein the composition with soothing and barrier repairing functions comprises 5-40 parts of glycerol glucoside and 10-70 parts of lactobacillus / algae extract fermentation product by weight.

[0011] The lipids between epidermal cells are mainly composed of ceramide, cholesterol and fatty acids, which are crucial to maintaining the integrity of the skin barrier. The glycerol glucoside provided by the present invention has a 2α structure. Compared with other isomers, the 2α-configured glycerol glucoside can cleverly shuttle between these lipid molecules to transmit signals without damaging their structures. Glycerol glucoside is a pure natural active ingredient derived from cyanobacteria and can form hydrogen bonds with water molecules. Due to its specific 2α configuration, the hydrogen bonds formed are more stable and lasting, and can adsorb and lock a large number of water molecules, and perform well in moisturizing. Ceramide is an important component of the skin barrier. Glycerol glucoside can promote the synthesis of ceramide in skin cells and accelerate the repair of the skin barrier.

[0012] The lactobacillus / algae extract fermentation product is produced by the co-fermentation of lactobacillus and tiny algae. Lactobacillus utilizes the nutrients in the algae extract for metabolic transformation to generate a series of small molecule natural peptides, organic acids and other ingredients with high biological activity; it can regulate the balance of skin microbial communities on the skin surface and inhibit the growth of harmful bacteria; at the same time, it can transmit soothing signals, effectively reduce the discomfort symptoms such as redness and stinging caused by inflammatory reactions, enhance the ability to soothe skin inflammation, strengthen the skin barrier, and reduce skin sensitivity.

[0013] The present invention creatively discovers that a composition composed of glycerol glucoside and lactobacillus / algae extract fermentation products can repair the skin barrier, has significant effects in soothing, repairing and anti-oxidation, and the two have a synergistic effect on the above effects; when the two are combined in a specific mass ratio, the above effects are more significant.

[0014] The weight proportions of the glycerol glucoside may be 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts or 40 parts, etc.

[0015] The weight proportions of the lactobacillus / algae extract fermentation product can be 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65 or 70 parts, etc.

[0016] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0017] Preferably, the composition with soothing and barrier repairing functions further comprises 0.1-1 parts by weight of an antioxidant.

[0018] The weight proportion of the antioxidant can be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part, etc.

[0019] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0020] Preferably, the antioxidant comprises any one of p-hydroxyacetophenone, tocopheryl acetate or retinyl palmitate, or a combination of at least two thereof.

[0021] Preferably, the composition having soothing and barrier repairing functions further comprises 10-80 parts by weight of a solvent.

[0022] The weight proportions of the solvent may be 10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts or 80 parts, etc.

[0023] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0024] Preferably, the solvent comprises polyol and deionized water.

[0025] Preferably, the polyol includes any one or a combination of at least two of 1,2-hexanediol, 1,2-pentanediol, ethylene glycol, propylene glycol, butylene glycol, dipropylene glycol, glycerol, polyethylene glycol or sorbitol.

[0026] Preferably, the composition with soothing and barrier repairing functions comprises, by weight, 5-40 parts of glycerol glucoside, 10-70 parts of lactobacillus / algae extract fermentation product, 0.1-1 parts of antioxidant, 0.8-6 parts of polyol and 10-70 parts of deionized water.

[0027] The weight proportions of the glycerol glucoside may be 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts or 40 parts, etc.

[0028] The weight proportions of the lactobacillus / algae extract fermentation product can be 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65 or 70 parts, etc.

[0029] The weight proportion of the antioxidant can be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part, etc.

[0030] The weight proportions of the polyol may be 0.8 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts or 6 parts, etc.

[0031] The weight proportions of the deionized water may be 10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts or 70 parts.

[0032] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0033] In a second aspect, the present invention provides a use of the composition with soothing and barrier repairing functions as described in the first aspect in the preparation of cosmetics.

[0034] Preferably, the cosmetics include lotions, emulsions, creams, essences, sprays, facial masks, sunscreens or skin care products.

[0035] Preferably, the mass percentage of the composition with soothing and barrier repair functions in the cosmetic is 0.001-25%, for example, it can be 0.001%, 1%, 2%, 5%, 8%, 10%, 12%, 15%, 18%, 20%, 22% or 25%, etc.

[0036] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0037] Preferably, the cosmetic further comprises any one or a combination of at least two of an antioxidant, a skin conditioner, a moisturizer, an emulsifier, a thickener, a solubilizer, a pH adjuster, a chelating agent, a solvent, a preservative or a fragrance.

[0038] In a third aspect, the present invention provides a skin care lotion with soothing and barrier repairing functions, which comprises, by weight, 0.001-25 parts of the composition with soothing and barrier repairing functions described in the first aspect, 0.5-10 parts of a moisturizer, 0.1-5 parts of an antioxidant, 0.5-20 parts of an emulsifier, 0.1-10 parts of an emulsifier, 0.1-3 parts of a thickener and 20-90 parts of deionized water.

[0039] The present invention creatively discovers that a skin care lotion prepared from glycerol glucoside and a fermentation product of lactobacillus / algae extract has excellent effects of moisturizing, firming the skin, enhancing elasticity, removing redness and blackness, and whitening and brightening the skin.

[0040] The weight proportions of the composition with soothing and barrier repairing functions may be 0.001 parts, 1 parts, 2 parts, 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, etc.

[0041] The weight proportion of the moisturizing agent can be 0.5 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts, etc.

[0042] The weight proportion of the antioxidant can be 0.1 parts, 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts, etc.

[0043] The weight proportions of the emollient can be 0.5 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 12 parts, 15 parts, 18 parts or 20 parts, etc.

[0044] The weight proportions of the emulsifier may be 0.1 parts, 0.5 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts, etc.

[0045] The weight proportions of the thickener may be 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts or 3 parts, etc.

[0046] The weight proportions of the deionized water may be 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85 or 90 parts, etc.

[0047] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0048] Preferably, the moisturizing agent includes any one of glycerin, 1,2-hexanediol, propylene glycol, 1,2-pentanediol or sodium hyaluronate, or a combination of at least two thereof.

[0049] Preferably, the antioxidant comprises any one of p-hydroxyacetophenone, tocopheryl acetate or retinyl palmitate, or a combination of at least two thereof.

[0050] Preferably, the emollient comprises any one of jojoba seed oil, argania spinosa kernel oil, dimethicone, squalane, C10-18 fatty acid triglycerides, cetyl ethylhexanoate or diisostearyl malate, or a combination of at least two thereof.

[0051] Preferably, the emollient comprises a combination of jojoba seed oil, argania spinosa kernel oil and dimethicone.

[0052] The emollient in the present invention is preferably a combination of jojoba seed oil, argania spinosa kernel oil and polydimethylsiloxane. The three ingredients have a synergistic effect and can further enhance the effects of moisturizing, whitening and brightening, barrier repair, anti-oxidation and anti-aging.

[0053] Preferably, the emulsifier includes any one of glyceryl stearate, PEG-100 stearate, cetearyl alcohol, C14-22 alkyl alcohol / C12-20 alkyl glucoside, hydrogenated lecithin, behenyl alcohol, sorbitan stearate, sorbitan isostearate, polyglyceryl-10 myristate or polysorbate-60, or a combination of at least two thereof.

[0054] Preferably, the thickener comprises xanthan gum and / or carbomer.

[0055] In a fourth aspect, the present invention provides a method for preparing the skin care lotion with soothing and barrier repairing functions as described in the third aspect, the preparation method comprising:

[0056] (1) Mixing a humectant and an antioxidant, heating and keeping the mixture warm, to obtain phase A; and then mixing the mixture with a thickener and deionized water, to obtain phase B;

[0057] Mix the emulsifier and the emollient, heat and keep warm to obtain phase C;

[0058] (2) Mix phase B and phase C, cool down, add the composition with soothing and barrier repairing functions described in the third aspect, and homogenize to obtain the skin care lotion.

[0059] Preferably, in step (1), the mixing method in preparing phase A, phase B and phase C is stirring.

[0060] Preferably, the stirring speed in the preparation of phase A is 30-40 rpm, for example, it can be 30 rpm, 31 rpm, 32 rpm, 33 rpm, 34 rpm, 35 rpm, 36 rpm, 37 rpm, 38 rpm, 39 rpm or 40 rpm, etc.; the stirring time is 5-15 min, for example, it can be 5 min, 6 min, 7 min, 8 min, 9 min, 10 min, 11 min, 13 min, 14 min or 15 min, etc.

[0061] Preferably, the stirring speed in the preparation of phase B is 3000-4000 rpm, for example, it can be 3000 rpm, 3100 rpm, 3200 rpm, 3300 rpm, 3400 rpm, 3500 rpm, 3600 rpm, 3700 rpm, 3800 rpm, 3900 rpm or 4000 rpm, etc.; the stirring time is 5-20 min, for example, it can be 5 min, 8 min, 10 min, 12 min, 15 min, 18 min or 20 min, etc.

[0062] Preferably, the stirring speed in the preparation of phase C is 30-40 rpm, for example, it can be 30 rpm, 31 rpm, 32 rpm, 33 rpm, 34 rpm, 35 rpm, 36 rpm, 37 rpm, 38 rpm, 39 rpm or 40 rpm, etc.; the stirring time is 5-15 min, for example, it can be 5 min, 6 min, 7 min, 8 min, 9 min, 10 min, 11 min, 13 min, 14 min or 15 min, etc.

[0063] Preferably, in step (1), the heating refers to raising the temperature to 80-85°C, for example, it can be 80°C, 80.5°C, 81°C, 81.5°C, 82°C, 82.5°C, 83°C, 83.5°C, 84°C, 84.5°C or 85°C.

[0064] Preferably, in step (1), the insulation temperature is 80-85°C, for example, 80°C, 80.5°C, 81°C, 81.5°C, 82°C, 82.5°C, 83°C, 83.5°C, 84°C, 84.5°C or 85°C; the insulation time is 5-15 min, for example, 5 min, 6 min, 7 min, 8 min, 9 min, 10 min, 11 min, 13 min, 14 min or 15 min.

[0065] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0066] Preferably, in step (2), the mixing temperature is 80-85°C, for example, it can be 80°C, 80.5°C, 81°C, 81.5°C, 82°C, 82.5°C, 83°C, 83.5°C, 84°C, 84.5°C or 85°C.

[0067] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0068] Preferably, in step (2), the mixing method is stirring.

[0069] Preferably, the stirring speed is 4000-6000 rpm, for example, it can be 4000 rpm, 4200 rpm, 4400 rpm, 4600 rpm, 4800 rpm, 5000 rpm, 5200 rpm, 5400 rpm, 5600 rpm, 5800 rpm or 6000 rpm, etc.; the stirring time is 5-10 min, for example, it can be 5 min, 5.5 min, 6 min, 6.5 min, 7 min, 7.5 min, 8min, 8.5 min, 9 min, 9.5 min or 10 min, etc.

[0070] Preferably, in step (2), the cooling refers to lowering the temperature to 20-50°C, for example, it can be 20°C, 22°C, 25°C, 28°C, 30°C, 32°C, 35°C, 38°C, 40°C, 42°C, 45°C, 48°C or 50°C.

[0071] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0072] Compared with the prior art, the present invention has the following beneficial effects:

[0073] (1) The present invention creatively discovered that the composition of glyceryl glucoside and lactobacillus / algae extract fermentation product can repair the skin barrier and has significant effects in soothing, repairing and anti-oxidation, and the two have a synergistic effect in the above effects; when the two are combined in a specific mass ratio, the above effects are more significant;

[0074] (2) The skin care lotion prepared from the fermentation product of glycerol glucoside and lactobacillus / algae extract has excellent effects of moisturizing, firming the skin, enhancing elasticity, removing redness and black spots, and whitening and brightening the skin; the emollient in the present invention is preferably a combination of jojoba seed oil, argania spinosa kernel oil and polydimethylsiloxane. The three ingredients have a synergistic effect and can further enhance the above effects. DETAILED DESCRIPTION

[0075] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0076] If no specific techniques or conditions are specified in the examples, the techniques or conditions described in the literature in the field or the product instructions are used. If no manufacturer is specified for the reagents or instruments used, they are all conventional products that can be purchased through regular channels.

[0077] The sources of materials used in the following specific embodiments are as follows:

[0078] Table 1

[0079]

[0080] Example 1

[0081] This embodiment provides a composition with soothing and barrier repair functions, which includes the following components in parts by weight:

[0082] Table 2

[0083]

[0084] The preparation method comprises the following steps: uniformly mixing the above product raw materials.

[0085] Example 2

[0086] This embodiment provides a composition with soothing and barrier repair functions, which includes the following components in parts by weight:

[0087] Table 3

[0088]

[0089] The preparation method comprises the following steps: uniformly mixing the above product raw materials.

[0090] Example 3

[0091] This embodiment provides a composition with soothing and barrier repair functions, which includes the following components in parts by weight:

[0092] Table 4

[0093]

[0094] The preparation method comprises the following steps: uniformly mixing the above product raw materials.

[0095] Example 4

[0096] This embodiment provides a composition with soothing and barrier repair functions, which includes the following components in parts by weight:

[0097] Table 5

[0098]

[0099] The preparation method comprises the following steps: uniformly mixing the above product raw materials.

[0100] Comparative Example 1

[0101] This comparative example provides a composition with soothing and barrier repairing functions, which differs from Example 1 only in that it does not contain glycerol glucoside, and the reduced amount thereof is supplemented by lactobacillus / algae extract fermentation products, and other raw materials and contents remain unchanged.

[0102] The preparation method thereof is as described in Example 1.

[0103] Comparative Example 2

[0104] This comparative example provides a composition with soothing and barrier repairing functions, which differs from Example 1 only in that it does not contain lactobacillus / algae extract fermentation product, and the reduced amount thereof is supplemented by glycerol glucoside, and other raw materials and contents remain unchanged.

[0105] The preparation method thereof is as described in Example 1.

[0106] Application Example 1

[0107] This application example provides a skin care lotion with soothing and barrier repairing functions, which includes the following components in parts by weight:

[0108] Table 6

[0109]

[0110] The preparation method is as follows:

[0111] (1) Heat the humectant and antioxidant to 85°C and keep warm, stirring at 35 rpm for 10 min to obtain phase A; then stir with the thickener and deionized water at 3500 rpm for 15 min to obtain phase B;

[0112] The emulsifier and emollient were heated to 85°C and kept warm, and stirred at 35 rpm for 10 min to obtain phase C;

[0113] (2) Phase B and phase C were stirred at 85° C. and 5000 rpm for 8 min, then cooled to 45° C., and the composition with soothing and barrier repairing functions prepared in Example 1 was added and homogenized to obtain the skin care lotion.

[0114] Application Example 2

[0115] This application example provides a skin care lotion with soothing and barrier repairing functions, which includes the following components in parts by weight:

[0116] Table 7

[0117]

[0118] The preparation method is as follows:

[0119] (1) Heat the humectant and antioxidant to 80°C and keep warm, stirring at 30 rpm for 15 min to obtain phase A; then stir with the thickener and deionized water at 3000 rpm for 20 min to obtain phase B;

[0120] The emulsifier and emollient were heated to 80°C and kept warm, and stirred at 30 rpm for 15 min to obtain phase C;

[0121] (2) Stir phase B and phase C at 80° C. and 4000 rpm for 10 min, then cool to 40° C., add the composition with soothing and barrier repairing functions prepared in Example 2, and homogenize to obtain the skin care lotion.

[0122] Application Example 3

[0123] This application example provides a skin care lotion with soothing and barrier repairing functions, which includes the following components in parts by weight:

[0124] Table 8

[0125]

[0126] The preparation method is as follows:

[0127] (1) Heat the humectant and antioxidant to 82°C and keep warm, stirring at 40 rpm for 5 min to obtain phase A; then stir with the thickener and deionized water at 4000 rpm for 5 min to obtain phase B;

[0128] The emulsifier and emollient were heated to 82°C and kept warm, and stirred at 40 rpm for 5 min to obtain phase C;

[0129] (2) Phase B and phase C were stirred at 82° C. and 6000 rpm for 5 min, then cooled to 50° C., and the composition with soothing and barrier repairing functions prepared in Example 3 was added and homogenized to obtain the skin care lotion.

[0130] Application Example 4

[0131] This application example provides a skin care lotion with soothing and barrier repair functions. The only difference between it and Application Example 1 is that the "composition with soothing and barrier repair functions prepared in Example 1" is replaced with an equal amount of the "composition with soothing and barrier repair functions prepared in Example 4", and other raw materials and contents remain unchanged.

[0132] The preparation method thereof refers to Application Example 1.

[0133] Application Example 5

[0134] This application example provides a skin care lotion with soothing and barrier repairing functions. The only difference between this application example and application example 1 is that it does not contain jojoba seed oil, and the reduced amount thereof is proportionally distributed to the other two components of the emollient, while the other raw materials and contents remain unchanged.

[0135] The preparation method thereof refers to Application Example 1.

[0136] Application Example 6

[0137] This application example provides a skin care lotion with soothing and barrier repairing functions. The only difference between this application example and application example 1 is that it does not contain argania spinosa kernel oil, and its reduced amount is proportionally distributed to the other two components of the emollient, while other raw materials and contents remain unchanged.

[0138] The preparation method thereof refers to Application Example 1.

[0139] Application Example 7

[0140] This application example provides a skin care lotion with soothing and barrier repairing functions. The only difference between this application example and application example 1 is that it does not contain polydimethylsiloxane, and its reduced amount is proportionally distributed to the other two components of the emollient, while other raw materials and contents remain unchanged.

[0141] The preparation method thereof refers to Application Example 1.

[0142] Comparative Application Example 1-2

[0143] This comparative application example provides a skin care lotion with soothing and barrier repair functions, and the only difference between it and Application Example 1 is that the "composition with soothing and barrier repair functions prepared in Example 1" is replaced with an equal amount of "composition with soothing and barrier repair functions prepared in Comparative Example 1-2", and other raw materials and contents remain unchanged.

[0144] The preparation method thereof refers to Application Example 1.

[0145] Test Example 1 Soothing Performance Test

[0146] (1) Test principle: Hyaluronidase is a hydrolase that degrades hyaluronic acid. It is the main component of the extracellular matrix of the body's connective tissue and is related to most IgE-mediated type I and T-cell-mediated type IV allergic reactions. Therefore, the hyaluronidase in vitro inhibition test can reflect the relevance of the product to the skin's soothing, anti-allergic, and anti-inflammatory effects to a certain extent. Hyaluronic acid is a high-grade polysaccharide composed of D-glucuronic acid and N-acetylglucosamine, which can undergo a color reaction according to the N-methylglucosamine reaction method. The hyaluronidase inhibition rate of the sample can be determined by this reaction. This test determines the hyaluronidase inhibition rate of the sample according to the test method of the laboratory method (enzyme inhibition rate method) QTTZ-XZ-35 "Detailed Rules for the Verification and Testing of Cosmetic Soothing Efficacy", and compares it with the negative control to determine whether the sample has a soothing effect.

[0147] (2) Test steps: Take the compositions with soothing and barrier repair functions prepared in Examples 1-4 and Comparative Examples 1-2, and perform extraction pretreatment on the samples; react the pretreated samples with a hyaluronidase solution, and set up a negative control and a blank control at the same time, operate according to the detection kit, and measure the OD value; obtain the hyaluronidase content according to the standard curve, and calculate the hyaluronidase inhibition rate: Hyaluronidase inhibition rate (%) = (1-T / C) × 100, T is the hyaluronidase content of the sample solution, and C is the hyaluronidase content of the negative control.

[0148] (3) Test results: As shown in Table 9:

[0149] Table 9

[0150]

[0151] It can be seen from Table 9 that the composition with soothing and barrier repair functions provided by the present invention can significantly inhibit hyaluronidase and has excellent soothing performance. Glycerol glucoside and lactobacillus / algae extract fermentation products promote each other in this effect and have an unexpected synergistic effect. When the two are combined in a specific mass ratio, the effect is more significant.

[0152] Test Example 2 Antioxidant Performance Test

[0153] (1) Test principle: Excessive production of free radicals is the main cause of natural skin aging and photoaging. Therefore, scavenging free radicals can delay skin aging and reduce wrinkles. 1,1-Diphenyl-2-trinitrophenylhydrazine (DPPH) is a stable long-lived free radical. When a free radical scavenger is present, the light absorption of DPPH ethanol solution is weakened due to pairing with its single electron. The degree of fading of DPPH ethanol solution is linearly related to the number of electrons it accepts. This can be used to evaluate the ability of the test sample to scavenge free radicals, that is, its antioxidant property.

[0154] (2) Instruments and materials:

[0155] Main instruments: spectrophotometer;

[0156] Main reagents: DPPH, analytical grade; anhydrous methanol, analytical grade; ascorbic acid, analytical grade;

[0157] Solution preparation: first, dissolve 1 mg of DPPH in about 20 mL of anhydrous methanol, ultrasonicate for 5 min, and shake thoroughly to mix the upper and lower parts evenly; take 1 mL of the DPPH solution, measure the A value at 519 nm, and make the A value between 1.2 and 1.3; then prepare each sample solution, dilute the composition with soothing and barrier repair functions prepared in Example 1-4 and Comparative Example 1-2 with anhydrous methanol, and prepare a solution with a mass fraction of 1% of the composition.

[0158] (3) Test method: After the reaction solution is shaken, place it in a 37°C water bath for 15 min and then take it out. Use a UV-visible spectrophotometer to measure the absorbance of the solution.

[0159] The sample addition system for each group of experiments is shown in Table 10 below:

[0160] Table 10

[0161]

[0162] DPPH free radical scavenging rate (%) = (1-(A2-A3) / A1) × 100;

[0163] Where A1, A2, and A3 are the absorbance values ​​of C1, C2, and C3, respectively.

[0164] (4) The test results are shown in Table 11:

[0165] Table 11

[0166]

[0167] It can be seen from Table 11 that the composition with soothing and barrier repair functions provided by the present invention has excellent antioxidant properties, and glycerol glucoside and lactobacillus / algae extract fermentation products promote each other in this effect and have an unexpected synergistic effect, and when the two are combined in a specific mass ratio, the effect is more significant.

[0168] Test Example 3 Repair and soothing, moisturizing and firming, whitening and anti-wrinkle performance test

[0169] (1) Test sample: skin care lotion with soothing and barrier repairing functions prepared in Application Examples 1-7 and Comparative Application Examples 1-2;

[0170] (2) Testing method: 33 healthy Chinese male / female subjects with dry facial skin, lack of moisture, poor facial skin barrier function, TEWL base value of the test area>15, a certain degree of facial redness / red bloodshot, fine lines or wrinkles at the corners of the eyes, and conforming to the Asian type of "Skin Aging Atlas" Volume 2, Grades 1 to 6, aged 25-60 years old were selected. The before-and-after control method was used to measure the moisture content of the stratum corneum, transepidermal water loss, skin elasticity, skin melanin content, etc. of the subjects before using the test product, and after using the product for 2 weeks and 4 weeks. The evaluation results before and after product use were compared by statistical test methods to determine whether there was a statistical difference.

[0171] (2) Detection location

[0172] ① Cheek: moisture content of skin stratum corneum, transepidermal water loss, skin elasticity R2, skin melanin content, Visia-CR wrinkle area ratio; ② Whole face: Visia-CR skin red area ratio, Visia-CR skin redness a value, Visia-CR skin color L value, Visia-CR skin color ITA° value.

[0173] (3)① The cheek test results are shown in Table 12:

[0174] Table 12

[0175]

[0176] ② The full face test results are shown in Table 13:

[0177] Table 13

[0178]

[0179] ③ The results of the subjects' self-assessment are shown in Table 14:

[0180] Table 14

[0181]

[0182] It can be seen from Tables 12-14 that the skin care lotion prepared from glycerol glucoside and lactobacillus / algae extract fermentation product has excellent soothing and repairing, hydrating and moisturizing, skin firming, enhancing elasticity, removing redness and blackness, whitening and brightening effects. Glycerol glucoside and lactobacillus / algae extract fermentation product promote each other in this effect and have an unexpected synergistic effect. When the two are combined in a specific mass ratio, the effect is more significant. Among them, the emollient is preferably a combination of jojoba seed oil, argania spinosa kernel oil and polydimethylsiloxane. The three ingredients have a synergistic effect and can further enhance the above effects.

[0183] The present invention uses the above embodiments to illustrate a composition with soothing and barrier repairing functions and its application, but the present invention is not limited to the above embodiments, that is, it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0184] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0185] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A composition with soothing and barrier repairing functions, characterized in that: The composition with soothing and barrier repairing functions comprises 5-40 parts of glycerol glucoside and 10-70 parts of lactobacillus / algae extract fermentation product by weight.

2. The composition with soothing and barrier repairing functions according to claim 1, characterized in that: The composition with soothing and barrier repairing functions further comprises 0.1-1 parts of antioxidants by weight; The antioxidant includes any one of p-hydroxyacetophenone, tocopheryl acetate or retinyl palmitate or a combination of at least two thereof.

3. The composition with soothing and barrier repairing functions according to claim 1, characterized in that: The composition having soothing and barrier repairing functions further comprises 10-80 parts by weight of a solvent; The solvent includes polyol and deionized water; The polyol includes any one of 1,2-hexanediol, 1,2-pentanediol, ethylene glycol, propylene glycol, butylene glycol, dipropylene glycol, glycerol, polyethylene glycol or sorbitol, or a combination of at least two thereof.

4. The composition with soothing and barrier repairing functions according to any one of claims 1 to 3, characterized in that: The composition with soothing and barrier repairing functions comprises, by weight, 5-40 parts of glycerol glucoside, 10-70 parts of lactobacillus / algae extract fermentation product, 0.1-1 parts of antioxidant, 0.8-6 parts of polyol and 10-70 parts of deionized water.

5. Use of the composition with soothing and barrier repairing functions according to any one of claims 1 to 4 in the preparation of cosmetics, characterized in that: The cosmetics include lotions, emulsions, creams, essences, sprays, masks, sunscreen or skin care products; The mass percentage of the composition with soothing and barrier repairing functions in the cosmetic is 0.001-25%; The cosmetics may also include any one or a combination of at least two of an antioxidant, a skin conditioner, a moisturizer, an emulsifier, a thickener, a solubilizer, a pH adjuster, a chelating agent, a solvent, a preservative or a fragrance.

6. A skin care lotion with soothing and barrier repairing functions, characterized in that: The skin care lotion with soothing and barrier repairing functions comprises, by weight, 0.001-25 parts of the composition with soothing and barrier repairing functions described in any one of claims 1 to 4, 0.5-10 parts of a moisturizer, 0.1-5 parts of an antioxidant, 0.5-20 parts of an emollient, 0.1-10 parts of an emulsifier, 0.1-3 parts of a thickener and 20-90 parts of deionized water.

7. The skin care lotion with soothing and barrier repairing functions according to claim 6, characterized in that: The moisturizing agent includes any one of glycerin, 1,2-hexanediol, propylene glycol, 1,2-pentanediol or sodium hyaluronate, or a combination of at least two thereof; The antioxidant comprises any one or a combination of at least two of p-hydroxyacetophenone, tocopherol acetate or retinol palmitate; The emollient includes any one or a combination of at least two of jojoba seed oil, argania spinosa kernel oil, dimethicone, squalane, C10-18 fatty acid triglycerides, cetyl ethylhexanoate or diisostearyl malate; The emulsifier includes any one of glyceryl stearate, PEG-100 stearate, cetearyl alcohol, C14-22 alkyl alcohol / C12-20 alkyl glucoside, hydrogenated lecithin, behenyl alcohol, sorbitan stearate, sorbitan isostearate, polyglyceryl-10 myristate or polysorbate-60, or a combination of at least two thereof; The thickener includes xanthan gum and / or carbomer.

8. The skin care lotion with soothing and barrier repairing functions according to claim 6, characterized in that The emollients include a combination of jojoba seed oil, argania spinosa kernel oil, and dimethicone.

9. The method for preparing a skin care lotion with soothing and barrier repairing functions according to any one of claims 6 to 8, characterized in that: The preparation method comprises: (1) Mixing a humectant and an antioxidant, heating and keeping the mixture warm, to obtain phase A; and then mixing the mixture with a thickener and deionized water, to obtain phase B; Mix the emulsifier and the emollient, heat and keep warm to obtain phase C; (2) Mix phase B and phase C, cool down, add the composition with soothing and barrier repairing functions according to any one of claims 1 to 4, and homogenize to obtain the skin care lotion.

10. The preparation method according to claim 9, characterized in that: In step (1), the mixing method in preparing phase A, phase B, and phase C is stirring; The stirring speed in the preparation of phase A is 30-40 rpm, and the stirring time is 5-15 min; The stirring speed in the preparation of phase B is 3000-4000 rpm, and the stirring time is 5-20 min; The stirring speed in the preparation of phase C is 30-40 rpm, and the stirring time is 5-15 min; In step (1), the heating refers to raising the temperature to 80-85°C; In step (1), the insulation temperature is 80-85°C and the insulation time is 5-15 min; In step (2), the mixing temperature is 80-85°C; In step (2), the mixing method is stirring; the stirring speed is 4000-6000 rpm, and the stirring time is 5-10 min; In step (2), the cooling refers to lowering the temperature to 20-50°C.

Images