Foot odor removing cleaning solution and preparation method thereof

Abstract

The invention discloses a foot odor removing cleaning solution and a preparation method thereof. Wherein the cleaning solution comprises the following components in percentage by weight: 5%-10% of a silver ion solution, 1%-3% of an olive extract, 1%-5% of a citrus extract, 0.5%-1.2% of nano titanium dioxide, 0.7%-1.1% of a stabilizer, 4%-7% of plant essential oil and the balance of deionized water. According to the present invention, the microbial metabolism can be inhibited, and the short-chain fatty acid generation amount in the shoe can be indirectly reduced so as to achieve the deodorization effect.

Description

Technical Field

[0001] The invention relates to the field of cleaning technology, in particular to a foot odor removing cleaning liquid and a manufacturing method thereof. Background Art

[0002] The density of sweat glands in the feet is relatively high, and the amount of sweat secreted is relatively large. When the feet are tightly wrapped in shoes and socks, the evaporation of sweat is hindered, resulting in an increase in the local environmental temperature and humidity, which provides suitable conditions for the reproduction of microorganisms. In this environment, foot microorganisms decompose proteins in the stratum corneum of the skin and components such as urea and lactic acid in sweat to produce volatile organic compounds, which cause odor, commonly known as foot odor. The causes of foot odor can be divided into two categories: physiological and pathological. Physiological factors include differences in the secretion function of individual sweat glands. Some people are prone to foot odor due to the vigorous secretion of sweat glands on the soles of their feet. Pathological factors involve foot diseases such as tinea pedis, blisters, foot erosions, and keratolysis.

[0003] Huang Boneng et al. [Huang Boneng, Yuan Yubing, Lan Zhenxing, et al. Study on the components of human sweat and foot odor [J]. China Fiber Inspection, 2022 (1): 63-65.] conducted an in-depth analysis of the components of foot odor by using purge and trap-gas chromatography-mass spectrometry technology, and found that the foot odor mainly contained compounds such as ammonia, acetic acid, dimethylamine, hexanal, octanal, nonanal and decanal. Kanda et al. [KANDA F, YAG IE, FUKUDA M, et al. Elicitation of chemical compounds responsible for foot odor. British Journal of Dermatology, 1990, 122: 771-776.] used gas chromatography-mass spectrometry to analyze sock samples of individuals with different foot odor intensities. The results showed that individuals with strong foot odor had significantly increased production of short-chain fatty acids compared with individuals without obvious foot odor, especially the content of isovaleric acid was significantly different. These high levels of short-chain fatty acids are volatile substances produced after metabolism and decomposition of microbial communities. These substances include short-chain fatty acids such as isovaleric acid, which constitute the main components of foot odor. Summary of the invention

[0004] In view of this, the purpose of the present invention is to provide a deodorizing cleaning liquid and a method for manufacturing the same, which can inhibit the metabolic capacity of microorganisms and indirectly reduce the production of short-chain fatty acids in shoes to achieve a deodorizing effect.

[0005] According to one aspect of the present invention, a foot odor removal cleaning liquid is provided, wherein the cleaning liquid comprises the following components in percentage by weight:

[0006] Silver ion solution 5%-10%, olive extract 1%-3%, citrus extract 1%-5%, nano titanium dioxide 0.5%-1.2%, stabilizer 0.7%-1.1%, plant essential oil 4%-7%, and deionized water as the balance.

[0007] In the above technical scheme, silver ions attract negative charges on the cell membrane of microorganisms through their positive charge, and then penetrate the cell structure, destroy the cell molecular structure and cause intracellular damage. In addition, silver ions can also induce the formation of reactive oxygen species (ROS) in bacterial cells, block the cell signal transduction pathway, and thus achieve antibacterial effects. The active ingredients in olive extracts, such as oleuropein and hydroxytyrosol, exhibit broad-spectrum antibacterial properties, and their mechanisms of action include interfering with the amino acid pattern necessary for microbial growth, inactivating viruses or preventing viral uncoating and replication, directly penetrating infected cells, and irreversibly inhibiting microbial replication. Flavonoids in citrus extracts, with their antioxidant, anti-inflammatory, antibacterial and antiviral biological activities, may reduce odor in shoes by neutralizing free radicals and reducing inflammatory responses. Citrus extracts are rich in a variety of natural essential oils. These small molecule essential oils contain aldehydes, phenols and hydrocarbon components, which can efficiently, quickly and safely remove odors from the air. Citrus extracts also have strong broad-spectrum antibacterial properties. Olive and citrus extracts are rich in phenolic and flavonoid substances, especially oleuropein in olive extracts, which can inhibit microbial metabolism by affecting microbial metabolic processes, regulating microbial community structure, increasing oxidative stress levels, causing membrane damage, and reducing metabolic activity. Indirectly reduce the generation of short-chain fatty acids in shoes, thereby achieving a deodorizing effect. In addition, olive and citrus extracts have antioxidant effects and can scavenge free radicals, which are helpful for stain removal and skin protection during the cleaning process. Nano-titanium dioxide can decompose bacteria under photocatalysis and achieve an antibacterial effect. Under ultraviolet irradiation, nano-titanium dioxide produces electron-hole pairs. These electrons and holes separate and migrate to different positions on the particle surface, triggering a series of reactions to generate hydroxyl free radicals with strong oxidizing ability, attacking the organic matter of bacteria and causing bacterial decomposition. The role of stabilizers in cleaning fluids is to maintain product stability, prevent the decomposition or precipitation of active ingredients, and ensure that the cleaning fluid can be evenly distributed during use to achieve the best effect. Deionized water is used as a solvent to dissolve and mix the various components in the cleaning fluid so that they are evenly distributed and easy to use. Deionized water does not contain common dissolved impurities such as calcium, chloride, sodium, etc., so it will not interfere with the formulation of cleaning solutions.

[0008] In some embodiments, the stabilizer is one or more of polyvinyl pyrrolidone, sodium carboxymethyl cellulose, starch, sodium carboxymethyl starch, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, talc, and a natural low eutectic solvent of choline chloride.

[0009] In the above technical scheme, polyvinyl pyrrolidone (PVP): polyvinyl pyrrolidone (PVP) is widely recognized for its excellent solubility, chemical stability, film-forming ability, low toxicity and biocompatibility. The polymer exhibits excellent adhesion and protective colloid properties, and can form stable complexes with a variety of inorganic and organic compounds. Sodium carboxymethyl cellulose (CMC): Sodium carboxymethyl cellulose (CMC) exists in the form of white or milky white fibrous powder or granules. It has excellent dispersibility in water and can form a transparent colloidal solution, but is insoluble in organic solvents such as ethanol. CMC has a certain stability to heat, and its viscosity rises rapidly below 20°C and changes more slowly at 45°C, but long-term heating above 80°C may cause colloid denaturation, thereby significantly reducing its viscosity and performance. CMC shows good stability in an alkaline environment, but is easily hydrolyzed in an acidic environment (pH value is about 2-3), and precipitation reactions may occur when encountering polyvalent metal salts. Sodium carboxymethyl starch (CMS): Sodium carboxymethyl starch (CMS) is usually used in the form of its sodium salt. It is a white or yellow powder that is odorless, tasteless, non-toxic and hygroscopic. The substance forms a colloidal solution after dissolving in water. It is stable to light and heat and exhibits multifunctional properties such as thickening, suspension, dispersion, emulsification, bonding, water retention and protective colloid. Low-substituted hydroxypropyl cellulose (L-HPC): Low-substituted hydroxypropyl cellulose (L-HPC) exists in the form of white to yellow-white powder or granules. It is odorless or slightly odorous and tasteless. L-HPC has a variety of particle sizes and substitution levels, so it exhibits different physical and chemical properties. Talc: Talc, as a stabilizer, can provide excellent lubricity and anti-sticking properties, thereby improving the processing performance of the product. Choline chloride: Choline chloride, as a natural low eutectic solvent, can enhance the stability and uniformity of the product, especially in water-based cleaning fluids. In summary, the selection of these stabilizers is intended to ensure the stability of the cleaning solution, prevent the decomposition or precipitation of the active ingredients, and ensure that the cleaning solution can be evenly distributed during use to achieve the best effect. The physical and chemical properties of these stabilizers make them play a key role in maintaining the performance of the cleaning solution.

[0010] In some embodiments, the stabilizer is a component in the following weight percentages: polyvinyl pyrrolidone 0.4%-0.8%, sodium carboxymethyl cellulose 0.1%-0.3%.

[0011] In the above technical scheme, in order to ensure the stability of the cleaning solution, we have selected the above ingredients and specific weight percentages. Polyvinyl pyrrolidone is preferred because of its excellent complexing ability and dispersibility. The polymer can effectively adsorb on the surface of silver nanoparticles to form a stable protective layer, thereby preventing silver ions from aggregating and precipitating in the solution. In addition, the addition of polyvinyl pyrrolidone significantly improves the stability of the silver ion solution, ensuring that it maintains high biological activity during storage and use. Storage temperature has a significant effect on the preservation of oleuropein content in olive extract. Under storage conditions of -20°C, the stability of olive extract is the best, while under storage conditions of 25°C, the degradation of oleuropein and total phenol content is more serious. With the extension of storage time, the degradation rate of oleuropein gradually increases. Specifically, after storage at 25°C for 27 days, the degradation rate of oleuropein reached 95.24%, while the degradation rate was 38.1% after storage at 4°C for 27 days. These data show that low-temperature storage is essential for maintaining the stability of active ingredients in olive extract. Sodium carboxymethyl cellulose was selected as a stabilizer for olive extract due to its good water solubility and chemical stability. Sodium carboxymethylcellulose is able to form a stable colloidal solution in the olive extract, which helps maintain the stability of the extract. By interacting with the active ingredients in the extract, sodium carboxymethylcellulose helps prevent their decomposition, thereby maintaining the biological activity and functionality of the extract. In summary, the addition of polyvinyl pyrrolidone and sodium carboxymethylcellulose not only improves the stability of the key ingredients in the cleaning solution, but also helps maintain the uniformity and effectiveness of the entire formula.

[0012] In some embodiments, the pH value of the cleaning solution is between 5 and 6.

[0013] In the above technical scheme, the experimental results show that oleuropein exhibits the best stability at a pH value of 5. Sodium carboxymethylcellulose (CMC), as a carboxymethyl derivative of cellulose, has excellent water solubility and can form a transparent colloidal solution. In aqueous solution, the pH value of a 1% solution of CMC ranges from 6.5 to 8.0, and within this pH range, the viscosity of the colloidal solution of CMC remains stable. When the pH value of the solution is greater than 10 or less than 5, the viscosity of the CMC colloid is significantly reduced, and its performance is optimal at a pH value of 7. In addition, the solubility of CMC in water is 20 mg / ml, indicating that it has good solubility in water. Therefore, when CMC is used as a stabilizer for olive extract, it can be directly dissolved in water without producing a thickening effect, which makes it an ideal choice for a stabilizer. At the same time, it was observed that CMC precipitates at a pH value of 2-3. In order to avoid adverse reactions between CMC and silver ions, the pH value of the solution should be avoided from being adjusted to this range. Taking all factors into consideration, it is recommended to maintain the pH value between 5 and 6 to ensure the stability of CMC while avoiding potential reactions with silver ions, thereby maintaining the stability and effectiveness of the components in the cleaning solution.

[0014] In some embodiments, the plant essential oil includes: one or more of longan flower essential oil, mango essential oil, pineapple essential oil, and guava essential oil.

[0015] In the above technical scheme, the active ingredients contained in plant essential oils, especially phenolic compounds, have been proven to have selective inhibitory effects on pathogenic microorganisms, can destroy bacterial cell walls and cell membranes, interfere with energy metabolism systems, affect whole cell proteins, DNA and metabolomes, change cell morphology, affect cell division, destroy motility, inhibit biofilm formation, affect QS activity, coagulate cytoplasm, interfere with signal transduction systems and affect toxicity, etc. These essential oils can significantly inhibit bacterial growth and reduce the microbial sources of odor in shoes. The phenolic, aldehyde, oxide and monoterpene chemical components rich in essential oils not only have strong characteristics of inhibiting or killing microorganisms such as fungi, but also have strong surface cleaning effects, which can remove dirt on the surfaces of furniture and household appliances. These ingredients, as natural cleaning agents, can effectively remove stains and odors in shoes. Plant essential oils are secondary substances in plants, which have multiple biological activities such as contact killing, stomach poisoning, repelling, refusal to feed and inhibiting growth of pests. Therefore, these essential oils can be used as natural insect repellents and mites removers, providing a safe and effective alternative, especially for families with elderly people and children. The natural aromatic smell of essential oils can not only make cleaning work pleasant, but also remove odors, purify the air, provide a lasting fragrance, and improve the wearing experience. Pure plant natural ingredients are highly safe and can replace detergents containing toxic substances without hurting the skin. In summary, these plant essential oils can be used as additives for shoe deodorizing cleaning liquids, which can not only effectively remove odors and inhibit bacterial growth, but also provide a safe, economical and pleasant cleaning experience. It should be pointed out that extracts refer to mixtures of non-volatile components extracted from plant materials by solvent extraction, cold pressing or other methods. These extracts may contain a variety of compounds, such as polyphenols, flavonoids, vitamins and other bioactive substances. Essential oils refer to volatile oils obtained from plants by distillation, cold pressing or other extraction methods. They are mainly composed of terpenoids, including monoterpenes and sesquiterpenes, and their derivatives, which give essential oils their unique aroma and flavor. Olive and citrus extracts differ significantly from their essential oil counterparts in their chemical composition and applications. Extracts typically contain a broader range of non-volatile compounds, while essential oils are rich in volatile compounds that impart a unique aroma and specific therapeutic properties.

[0016] According to another aspect of the present invention, a method for preparing a foot odor removal cleaning liquid is provided, which is used to prepare the above-mentioned foot odor removal cleaning liquid;

[0017] Measure an appropriate amount of deionized water as a solvent and pour it into a container. According to the formula ratio, measure the silver ion solution and add it into the container and stir;

[0018] Add olive extract, citrus extract, nano titanium dioxide and stabilizer in order according to the formula ratio and stir;

[0019] Add the essential oil according to the formula ratio and stir with ultrasonic;

[0020] After all ingredients are added to the container, continue to stir with agitator for 10-30 minutes;

[0021] Pour the prepared cleaning solution into a spray bottle.

[0022] In the above technical solution, the preparation process not only ensures product quality, but also takes into account the ease of operation and cost-effectiveness, and is suitable for large-scale production and daily use.

[0023] In some embodiments, the olive extract is extracted from olive leaves using supercritical CO2 extraction technology, and the extraction process is as follows: extraction pressure 25MPa~30MPa, extraction temperature 40℃~50℃, extraction time 3 hours~4 hours.

[0024] In the above technical scheme, supercritical CO2 extraction technology can almost completely extract the required components under the optimal process conditions, thereby greatly improving the product yield and resource utilization. Selective extraction: By changing the temperature and pressure during the operation, multiple substances can be selectively separated, thereby reducing impurities and highly enriching the effective ingredients. The process of extracting oleuropein with supercritical carbon dioxide includes crushing the olive leaves into fine particles, then putting them into a supercritical extraction device, and passing carbon dioxide for dynamic extraction. After extraction, separation is carried out through separation tanks with different pressures and temperatures to obtain olive leaf active extracts at different stages. At the same time, the above-mentioned optimal process parameter range is obtained based on multiple experiments.

[0025] In some embodiments, the citrus extract is extracted from citrus peel or citrus fruit using supercritical CO2 extraction technology, and the extraction process is as follows: extraction pressure 10MPa~30MPa, extraction temperature 30℃~45℃, extraction time 2 hours~3 hours.

[0026] In the above technical scheme, supercritical CO2 extraction technology can almost completely extract the required components under the optimal process conditions, thereby greatly improving the product yield and resource utilization. Selective extraction: By changing the temperature and pressure during the operation, multiple substances can be selectively separated, thereby reducing impurities and highly enriching the effective ingredients. The process of extracting citrus extract with supercritical carbon dioxide includes crushing citrus peel residue or citrus fallen fruits into fine particles, which are then put into a supercritical extraction device and dynamically extracted by introducing carbon dioxide. After extraction, citrus extracts at different stages are separated by separation tanks at different pressures and temperatures. At the same time, the above-mentioned optimal process parameter range is obtained based on multiple experiments. DETAILED DESCRIPTION

[0027] The present invention will be further described in detail below in conjunction with the embodiments. It is particularly noted that the following embodiments are only used to illustrate the present invention, but are not intended to limit the scope of the present invention. Similarly, the following embodiments are only partial embodiments of the present invention rather than all embodiments, and all other embodiments obtained by those of ordinary skill in the art without creative work are within the scope of protection of the present invention.

[0028] The invention provides a foot odor removing cleaning liquid and a preparation method thereof, which can inhibit the metabolic ability of microorganisms and indirectly reduce the generation of short-chain fatty acids in shoes to achieve a deodorizing effect.

[0029] Embodiment 1

[0030] A foot odor removing cleaning liquid, the cleaning liquid comprises the following components in percentage by weight:

[0031] Silver ion solution 5%-10%, olive extract 1%-3%, citrus extract 1%-5%, nano titanium dioxide 0.5%-1.2%, stabilizer 0.7%-1.1%, plant essential oil 4%-7%, and deionized water as the balance.

[0032] In this embodiment, silver ions have broad-spectrum antibacterial properties and can effectively inhibit bacterial growth. According to the search results, the concentration of silver ions in the silver ion antibacterial hand sanitizer is crucial to the antibacterial effect. Therefore, the optimal ratio is selected as 10% to ensure the best antibacterial effect. Olive extract and citrus extract are similarly selected at 3% and 5%. Nano titanium dioxide can effectively decompose bacteria under photocatalysis. Considering its performance in antibacterial and light stability, 1.2% is selected. Stabilizers are essential for maintaining product stability. Considering the need to reduce unnecessary chemical additions while maintaining product performance, 0.7% is selected. Plant essential oils provide natural aroma and have antibacterial effects. In order to provide the best aroma experience and enhance the antibacterial effect, 7% is selected. The balance is deionized water, which is used as a solvent to dissolve and mix the various components in the cleaning solution, and its proportion will be adjusted according to the sum of other components.

[0033] In this embodiment, silver ions attract negative charges on the microbial cell membrane through their positive charge, and then penetrate the cell structure, destroy the cell molecular structure and cause intracellular damage. In addition, silver ions can also induce the formation of reactive oxygen species (ROS) in bacterial cells, blocking the cell signal transduction pathway, thereby achieving an antibacterial effect. The active ingredients in olive extracts, such as oleuropein and hydroxytyrosol, exhibit broad-spectrum antibacterial properties, and their mechanisms of action include interfering with the amino acid pattern necessary for microbial growth, inactivating viruses or preventing viral uncoating and replication, directly penetrating infected cells, and irreversibly inhibiting microbial replication. The flavonoids in citrus extracts, with their antioxidant, anti-inflammatory, antibacterial and antiviral biological activities, may reduce odor in shoes by neutralizing free radicals and reducing inflammatory responses. Citrus extracts are rich in a variety of natural essential oils, which contain aldehydes, phenols and hydrocarbon components, and can efficiently, quickly and safely remove odors from the air. Citrus extracts also have strong broad-spectrum antibacterial properties. Olive and citrus extracts are rich in phenolic and flavonoid substances, especially oleuropein in olive extracts, which can inhibit microbial metabolism by affecting microbial metabolic processes, regulating microbial community structure, increasing oxidative stress levels, causing membrane damage, and reducing metabolic activity. Indirectly reduce the generation of short-chain fatty acids in shoes, thereby achieving a deodorizing effect. In addition, olive and citrus extracts have antioxidant effects and can scavenge free radicals, which are helpful for stain removal and skin protection during the cleaning process. Nano-titanium dioxide can decompose bacteria under photocatalysis and achieve an antibacterial effect. Under ultraviolet irradiation, nano-titanium dioxide produces electron-hole pairs. These electrons and holes separate and migrate to different positions on the particle surface, triggering a series of reactions to generate hydroxyl free radicals with strong oxidizing ability, attacking the organic matter of bacteria and causing bacterial decomposition. The role of stabilizers in cleaning fluids is to maintain product stability, prevent the decomposition or precipitation of active ingredients, and ensure that the cleaning fluid can be evenly distributed during use to achieve the best effect. Deionized water is used as a solvent to dissolve and mix the various components in the cleaning fluid so that they are evenly distributed and easy to use. Deionized water does not contain common dissolved impurities such as calcium, chloride, sodium, etc., so it will not interfere with the formulation of cleaning solutions.

[0034] In this embodiment, the stabilizer is one or more of polyvinyl pyrrolidone, sodium carboxymethyl cellulose, starch, sodium carboxymethyl starch, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, talc, and choline chloride natural low eutectic solvents. Polyvinyl pyrrolidone (PVP): Polyvinyl pyrrolidone (PVP) is widely recognized for its excellent solubility, chemical stability, film-forming ability, low toxicity and biocompatibility. The polymer exhibits excellent adhesion and protective colloid properties and can form stable complexes with a variety of inorganic and organic compounds. Sodium carboxymethyl cellulose (CMC): Sodium carboxymethyl cellulose (CMC) exists in the form of white or milky white fibrous powder or granules. It has excellent dispersibility in water and can form a transparent colloidal solution, but is insoluble in organic solvents such as ethanol. CMC has a certain stability to heat, and its viscosity rises rapidly below 20°C and changes slowly at 45°C, but long-term heating above 80°C may cause colloid denaturation, thereby significantly reducing its viscosity and performance. CMC shows good stability in alkaline environment, but is prone to hydrolysis in acidic environment (pH about 2-3), and may undergo precipitation reaction when encountering polyvalent metal salts. Sodium carboxymethyl starch (CMS): Sodium carboxymethyl starch (CMS) is usually used in the form of its sodium salt. It is a white or yellow powder with the characteristics of being odorless, tasteless, non-toxic and hygroscopic. The substance forms a colloidal solution after dissolving in water, which is stable to light and heat, and exhibits multifunctional properties such as thickening, suspension, dispersion, emulsification, bonding, water retention and protective colloid. Low-substituted hydroxypropyl cellulose (L-HPC): Low-substituted hydroxypropyl cellulose (L-HPC) exists in the form of white to yellow-white powder or granules. It is odorless or slightly odorous and tasteless. L-HPC has a variety of particle sizes and substitution levels, so it exhibits different physical and chemical properties. Talc: Talc, as a stabilizer, can provide excellent lubricity and anti-sticking properties, thereby improving the processing performance of the product. Choline chloride: As a natural deep eutectic solvent, choline chloride can enhance the stability and uniformity of the product, especially in water-based cleaning fluids. In summary, the selection of these stabilizers is aimed at ensuring the stability of the cleaning fluid, preventing the decomposition or precipitation of the active ingredients, and ensuring that the cleaning fluid can be evenly distributed during use to achieve the best effect. The physical and chemical properties of these stabilizers make them play a key role in maintaining the performance of the cleaning fluid.

[0035] As an optimal solution, the stabilizer is a component with the following weight percentage: polyvinyl pyrrolidone 0.4%-0.8%, sodium carboxymethyl cellulose 0.1%-0.3%. In order to ensure the stability of the cleaning solution, we have selected the above ingredients and specific weight percentages. Polyvinyl pyrrolidone is preferred because of its excellent complexing ability and dispersibility. The polymer can be effectively adsorbed on the surface of silver nanoparticles to form a stable protective layer, thereby preventing silver ions from aggregating and precipitating in the solution. In addition, the addition of polyvinyl pyrrolidone significantly improves the stability of the silver ion solution, ensuring that it maintains a high biological activity during storage and use. Storage temperature has a significant effect on the preservation of oleuropein content in olive extract. Under storage conditions of -20°C, the stability of olive extract is the best, while under storage conditions of 25°C, the degradation of oleuropein and total phenol content is more serious. With the extension of storage time, the degradation rate of oleuropein gradually increases. Specifically, after 27 days of storage at 25°C, the degradation rate of oleuropein reached 95.24%, while the degradation rate was 38.1% after 27 days of storage at 4°C. These data indicate that low temperature storage is essential for maintaining the stability of the active ingredients in olive extracts. Sodium carboxymethyl cellulose was selected as a stabilizer for olive extracts due to its good water solubility and chemical stability. Sodium carboxymethyl cellulose is able to form a stable colloidal solution in olive extracts, which helps maintain the stability of the extracts. By interacting with the active ingredients in the extracts. Sodium carboxymethyl cellulose helps prevent their decomposition, thereby maintaining the biological activity and functionality of the extracts. In summary, the addition of polyvinyl pyrrolidone and sodium carboxymethyl cellulose not only improves the stability of key ingredients in the cleaning solution, but also helps maintain the uniformity and effectiveness of the entire formula. The optimal combination of stabilizers is 0.4% polyvinyl pyrrolidone and 0.3% sodium carboxymethyl cellulose. The combined use of polyvinyl pyrrolidone and sodium carboxymethyl cellulose can produce a synergistic effect in improving the stability of the cleaning solution. The synergistic effect of polyvinyl pyrrolidone and sodium carboxymethyl cellulose can effectively improve the stability and performance of the cleaning solution, ensure that silver ions, plant essential oils and other ingredients are evenly distributed in the solution, prevent precipitation and separation, thereby extending the shelf life of the product and improving the use effect. In addition, the combination can ensure the effectiveness and uniformity of each component and improve the stability of the product. Therefore, this stabilizer combination not only optimizes the physicochemical properties of the product, but also helps maintain the biological activity and functionality of the active ingredients in the cleaning solution.

[0036] In this embodiment, the pH value of the cleaning solution is between 5 and 6, preferably 6. First, existing studies have shown that oleuropein has the best stability when the pH value is 5, and this combination helps to maintain the pH value, thereby optimizing the stability of oleuropein. Secondly, sodium carboxymethyl cellulose has good water solubility and stability at higher concentrations, but too high a concentration may cause an increase in viscosity, affecting the overall performance of the product. At the same time, the stability of oleuropein and the performance of sodium carboxymethyl cellulose are balanced. Finally, considering the possible adverse reactions of sodium carboxymethyl cellulose and silver ions, such as precipitation formation, this combination is selected to avoid adjusting the pH value to a range of 2-3, thereby preventing the potential reaction of sodium carboxymethyl cellulose with silver ions, and ensuring the compatibility and stability of the components in the cleaning solution. In summary, this stabilizer combination not only improves the stability of the product, but also ensures the effectiveness and uniformity of each component, providing a safe and efficient formulation for the cleaning solution.

[0037] In this embodiment, the experimental results show that oleuropein exhibits the best stability at a pH value of 5. Sodium carboxymethyl cellulose, as a carboxymethyl derivative of cellulose, has excellent water solubility and can form a transparent colloidal solution. In aqueous solution, the pH value of a 1% solution of sodium carboxymethyl cellulose ranges from 6.5 to 8.0, and within this pH range, the viscosity of the colloidal solution of sodium carboxymethyl cellulose remains stable. When the pH value of the solution is greater than 10 or less than 5, the viscosity of the sodium carboxymethyl cellulose colloid is significantly reduced, and at a pH value of 7, its performance is optimal. In addition, the solubility of sodium carboxymethyl cellulose in water is 20 mg / ml, indicating that it has good solubility in water. Therefore, when sodium carboxymethyl cellulose is used as a stabilizer for olive extract, it can be directly dissolved in water without a thickening effect, which makes it an ideal choice for a stabilizer. At the same time, it was observed that sodium carboxymethyl cellulose precipitates at a pH value of 2-3. In order to avoid adverse reactions between sodium carboxymethyl cellulose and silver ions, the pH value of the solution should be avoided from being adjusted to this range. Taking all factors into consideration, it is recommended to maintain the pH value between 5 and 6 to ensure the stability of sodium carboxymethyl cellulose while avoiding potential reaction with silver ions, thereby maintaining the stability and effectiveness of each component in the cleaning solution.

[0038] In the present embodiment, the plant essential oil includes: one or more of longan flower essential oil, mango essential oil, pineapple essential oil, and guava essential oil. The above essential oils are only for providing additional effects to the formula, and those skilled in the art can choose according to actual needs, and will not be repeated here. The active ingredients contained in the plant essential oils, especially phenolic compounds, have been proven to have selective inhibitory effects on pathogenic microorganisms, can destroy the cell wall and cell membrane of bacteria, interfere with the energy metabolism system, affect whole cell protein, DNA and metabolome, change cell morphology, affect cell division, destroy motility, inhibit biofilm formation, affect QS activity, coagulate cytoplasm, interfere with signal transduction system and affect toxicity, etc. These essential oils can significantly inhibit bacterial growth and reduce the microbial sources of odor in shoes. The phenolic, aldehyde, oxide and monoterpene chemical components rich in essential oils not only have strong characteristics of inhibiting or killing microorganisms such as fungi, but also have strong surface cleaning effects, and can remove dirt on the surfaces of furniture and household appliances. These ingredients, as natural cleaning agents, can effectively remove stains and odors in shoes. Plant essential oils are secondary substances in plants, which have multiple biological activities such as contact killing, stomach poisoning, repelling, repelling and inhibiting growth on pests. Therefore, these essential oils can be used as natural insect repellents and mites removers, providing safe and effective alternatives, especially for families with elderly people and children. The natural aroma of essential oils can not only make cleaning work pleasant, but also remove odors, purify the air, provide lasting fragrance, and improve the wearing experience. Pure plant natural ingredients are highly safe and can replace detergents containing toxic substances without hurting the skin. In summary, these plant essential oils can be used as additives for shoe deodorizing cleaning liquids, which can not only effectively remove odors and inhibit bacterial growth, but also provide a safe, economical and pleasant cleaning experience. It should be pointed out that extracts refer to mixtures of non-volatile components extracted from plant materials by solvent extraction, cold pressing or other methods. These extracts may contain a variety of compounds, such as polyphenols, flavonoids, vitamins and other bioactive substances. Essential oils refer to volatile oils obtained from plants by distillation, cold pressing or other extraction methods. They are primarily composed of terpenoids, including monoterpenes and sesquiterpenes, and their derivatives, which are responsible for the characteristic aroma and flavor of essential oils. Olive and citrus extracts differ significantly from their essential oil counterparts in terms of chemical composition and application. Extracts typically contain a wider range of non-volatile compounds, while essential oils are rich in volatile compounds that impart a unique aroma and specific therapeutic properties. The two are not the same.

[0039] Embodiment 2

[0040] A method for preparing a foot odor removal cleaning liquid, used for preparing a foot odor removal cleaning liquid as described in one of the embodiments;

[0041] S1. Take an appropriate amount of deionized water as a solvent and pour it into a container. According to the formula ratio, take a silver ion solution and add it into the container and stir.

[0042] S2, adding olive extract, citrus extract, nano titanium dioxide and stabilizer in order according to the formula ratio and stirring;

[0043] S3, adding the plant essential oil according to the formula ratio and stirring with ultrasonic wave;

[0044] S4. After all ingredients are added to the container, continue stirring for 10-30 minutes;

[0045] S5. Pour the prepared cleaning solution into the spray bottle.

[0046] In this embodiment, the preparation process not only ensures product quality, but also takes into account the ease of operation and cost-effectiveness, and is suitable for large-scale production and daily use.

[0047] In this embodiment, the olive extract is extracted from olive leaves using supercritical CO2 extraction technology. (There are many varieties of olive leaves. Here, only oleuropein needs to be extracted. The extraction rate is selected as an indicator.) The extraction process is as follows: extraction pressure 25MPa-30MPa, extraction temperature 40℃-50℃, extraction time 3 hours-4 hours. The optimal combination is: extraction pressure 25MPa, extraction temperature 45℃, extraction time 3 hours. It should be noted that in addition to the process parameters selected in this embodiment, other process parameters can be set according to actual needs, and the extraction rate is selected as an indicator. The above process parameters are the optimal parameter combination with the largest impact on the extraction rate provided by this embodiment. Supercritical CO2 extraction technology can almost completely extract the required components under the optimal process conditions, thereby greatly improving the product yield and resource utilization. Selective extraction: By changing the temperature and pressure during the operation, multiple substances can be selectively separated, thereby reducing impurities and highly enriching the effective ingredients. The process of extracting oleuropein with supercritical carbon dioxide includes crushing olive leaves into fine particles, then putting them into a supercritical extraction device and introducing carbon dioxide for dynamic extraction. After extraction, they are separated by separation tanks at different pressures and temperatures to obtain olive leaf active extracts at different stages.

[0048] In this embodiment, the citrus extract is extracted from citrus peel or citrus fruit by supercritical CO2 extraction technology, and the extraction process is as follows: extraction pressure 10MPa ~ 30MPa, extraction temperature 30 ℃ ~ 45 ℃, extraction time 2 hours ~ 3 hours. The optimal combination is: extraction pressure 15MPa, extraction temperature 35 ℃, extraction time 2.5 hours. It should be noted that, in addition to the process parameters selected in this embodiment, other process parameters can be set according to actual needs, and the higher the extraction rate is, the more optimal parameter combination with the greater impact on the extraction rate provided by this embodiment. Supercritical CO2 extraction technology can almost completely extract the required components under the optimal process conditions, thereby greatly improving the product yield and resource utilization. Selective extraction: By changing the temperature and pressure during the operation, multiple substances can be selectively separated, thereby reducing impurities and highly enriching the effective ingredients. The process of supercritical carbon dioxide extraction of citrus extract includes crushing citrus peel or citrus fruit into fine particles, then putting them into a supercritical extraction device, and passing carbon dioxide for dynamic extraction. After extraction, the citrus extracts at different stages are separated by separation tanks at different pressures and temperatures. At the same time, the above-mentioned optimal process parameter range is obtained based on multiple experiments.

[0049] Experimental design:

[0050] Silver ion solution, nano titanium dioxide, and plant essential oils are commonly used additives for existing sterilization and disinfection. The most effective formula for this case based on the existing technology is as above. This experiment is only to verify the effectiveness of the addition of olive extract and citrus extract, and to test the balance effect of the amount of stabilizer added. Only the olive extract, citrus extract, and stabilizer addition were used in single-factor experiments in sequence. The effects of silver ion solution, nano titanium dioxide, and plant essential oils are not further evaluated here. As mentioned in the background technology, the production of short-chain fatty acids in individuals with strong foot odor is significantly increased compared to individuals without obvious foot odor, especially the difference in the content of isovaleric acid is significant. These high-content short-chain fatty acids are volatile substances produced after metabolism and decomposition of microbial communities. These substances include short-chain fatty acids such as isovaleric acid, which constitute the main components of foot odor. The following experiment was designed for this purpose, as follows:

[0051] 1. Single factor experiment of olive extract

[0052] Variable: Olive extract concentration (0%, 1%, 2%, 3%)

[0053] Fixed variables: silver ion solution 10%, citrus extract 5%, nano titanium dioxide 1.2%, stabilizer 0.7%, plant essential oil 7%, deionized water balance, the preparation method is exactly the same.

[0054] Take 10 ml of deionized water (blank sample), 10 ml of olive extract with a concentration of 1%, olive extract with a concentration of 2%, and olive extract with a concentration of 3% and place them in four containers for later use.

[0055] Take 2mL of Staphylococcus epidermidis (the main bacterial flora that produces isovaleric acid) suspension, and use 30ml of molten agar medium to mix the bacterial liquid and the medium evenly, and wait for it to cool. Use sterile tweezers to immerse a 0.5cm diameter sterile disc filter paper in deionized water and each test sample for a while, take it out and place it in the center of the bacterial culture medium plate, place it at 37°C, culture it for 72h, and observe and measure the presence and size of the inhibition zone around the filter paper disc. Each group of experiments was repeated three times, and the average value was recorded, and they were numbered as blank sample, olive extract concentration 1%, olive extract concentration 2%, olive extract concentration 3%, and olive extract concentration 0%. The experimental results are shown in the following table:

[0056] Table 1 Single factor experimental results of olive extract (cm)

[0057]

[0058] Compared with other examples, the bactericidal and antibacterial effects of the olive extract concentration of 3% are significantly better, which shows that the olive extract can play a bactericidal role. Through the above steps, we can evaluate the deodorizing effect of different concentrations of olive extract in shoe cleaning spray, so as to determine the optimal olive extract concentration. This method is simple and intuitive, and can provide important sensory data for product development.

[0059] 2. Single factor experiment of citrus extract

[0060] Variable: Citrus extract concentration (0%, 1%, 3%, 5%)

[0061] Fixed variables: silver ion solution 10%, olive extract 3%, nano titanium dioxide 1.2%, stabilizer 0.7%, plant essential oil 7%, deionized water balance, the preparation method is exactly the same as above.

[0062] Table 2 Single factor experimental results of citrus extract (cm)

[0063]

[0064]

[0065] Compared with other examples, the bactericidal and antibacterial effect of 5% citrus extract is significantly better, which shows that 5% citrus extract can have a bactericidal effect, but the effect is obviously not as good as olive extract, proving that olive extract has a better effect in bactericidal effect. Through the above steps, we can evaluate the deodorizing effect of different concentrations of citrus extract in shoe cleaning spray, so as to determine the optimal concentration of citrus extract. This method is simple and intuitive, and can provide important sensory data for product development.

[0066] 3. Single factor experiment of stabilizer

[0067] Variables: Stabilizer concentration (0.7% (polyvinyl pyrrolidone 0.4%, sodium carboxymethyl cellulose 0.3%), 0.8% (polyvinyl pyrrolidone 0.6%, sodium carboxymethyl cellulose 0.2%), 1.1% (polyvinyl pyrrolidone 0.8%, sodium carboxymethyl cellulose 0.3%), 1.5% (polyvinyl pyrrolidone 1.0%, sodium carboxymethyl cellulose 0.5%)).

[0068] Fixed variables: silver ion solution 10%, olive extract 3%, citrus extract 5%, nano titanium dioxide 1.2%, plant essential oil 7%, deionized water balance, the preparation method is exactly the same.

[0069] Considering that cleaning solutions are generally stored at room temperature, away from sunlight, and in a cool place, in order to speed up the experiment, this experiment took three groups of 20 ml of cleaning solutions (optimal formula) and placed them at 50°C ± 2°C and 75% ± 5% relative humidity for 20 days (roughly estimated, equivalent to 2-3 months under long-term conditions (25°C ± 2°C and 60% RH ± 10% RH)) to accelerate experimental changes, and used high performance liquid chromatography (HPLC) to determine the content of oleuropein on the 20th day and whether there was precipitation as evaluation indicators, and the variable was the above experimental group.

[0070] Table 3 Stabilizer single factor experimental results (cm)

[0071]

[0072]

[0073] From the above experiments, it can be known that the stabilizer can well maintain the active ingredients in the olive extract. It can be seen from the table that the best effect is achieved when the content is 1.1%, but the improvement is limited compared to 0.7% to 0.9%. Furthermore, considering the need to reduce unnecessary chemical additions while maintaining product performance, 0.7% is selected. Of course, a stabilizer of 0.9% can also be selected. This case is selected based on the idea of ​​reducing chemical additions, and those skilled in the art can set it according to actual needs. At the same time, when the stabilizer concentration reaches 1.5%, the effect is not good. We speculate that due to the use of accelerated experiments, the temperature reaches 50℃±2℃, and the reaction of sodium carboxymethyl cellulose (CMC) and silver ions generates a slight precipitate. If the temperature is further increased, the effect may further decrease. Therefore, in the selection of stabilizers, sodium carboxymethyl cellulose should not be higher than 0.5%. For the sake of conservatism, it is set to 0.3% in this case.

[0074] The above descriptions are only some embodiments of the present invention, and are not intended to limit the protection scope of the present invention. Any equivalent device or equivalent process transformation made using the contents of the present invention specification, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A foot odor removing cleaning liquid, characterized in that: The cleaning solution is composed of the following components in weight percentage: Silver ion solution 5%-10%, olive extract 1%-3%, citrus extract 1%-5%, nano titanium dioxide 0.5%-1.2%, stabilizer 0.7%-1.1%, plant essential oil 4%-7%, and deionized water as the balance.

2. A foot deodorizing cleaning liquid as claimed in claim 1, characterized in that: The stabilizer is one or more of polyvinyl pyrrolidone, sodium carboxymethyl cellulose, starch, sodium carboxymethyl starch, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, talc, and a natural low eutectic solvent of choline chloride.

3. A foot odor removing cleaning liquid as claimed in claim 1 or 2, characterized in that: The stabilizer is composed of the following components in weight percentage: 0.4%-0.8% polyvinyl pyrrolidone and 0.1%-0.3% sodium carboxymethyl cellulose.

4. A foot odor removing cleaning liquid as claimed in claim 1, characterized in that: The pH value of the cleaning solution is between 5 and 6.

5. A foot odor removal cleaning liquid as claimed in claim 1, characterized in that: The plant essential oil comprises: one or more of longan flower essential oil, mango essential oil, pineapple essential oil and guava essential oil.

6. A method for producing a foot odor removing cleaning liquid, characterized in that: Used to prepare a foot odor removal cleaning liquid as described in any one of claims 1 to 5; Measure an appropriate amount of deionized water as a solvent and pour it into a container. According to the formula ratio, measure the silver ion solution and add it into the container and stir; Add olive extract, citrus extract, nano titanium dioxide and stabilizer in order according to the formula ratio and stir; Add the essential oil according to the formula ratio and stir with ultrasonic; After all ingredients are added to the container, continue to stir with agitator for 10-30 minutes; Pour the prepared cleaning solution into a spray bottle.

7. The method for producing a foot odor removing cleaning liquid as claimed in claim 6, characterized in that: The olive extract is extracted from olive leaves by supercritical CO2 extraction technology, and the extraction process is as follows: extraction pressure 25MPa-30MPa, extraction temperature 40°C-50°C, extraction time 3 hours-4 hours.

8. The method for producing a foot odor removing cleaning liquid as claimed in claim 6, characterized in that: The citrus extract is extracted from citrus peel residue or citrus fallen fruit by supercritical CO2 extraction technology, and the extraction process is as follows: extraction pressure 10MPa-30MPa, extraction temperature 30°C-45°C, extraction time 2 hours-3 hours.

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