Permeation promoting composition, preparation method thereof and application of permeation promoting composition in cleansing water

Abstract

The invention relates to a permeation promoting composition, a preparation method thereof and application of the permeation promoting composition in cleansing water, and belongs to the technical field of cosmetics. The permeation promoting composition is prepared from the following components: acanthopanax trifoliatus leaf extract, agave stem extract, perilla frutescens extract, soybean peptides, a humectant, an emulsifier, a surfactant, a skin conditioner, a preservative and a solvent. According to the present invention, the composite formula comprising the acanthopanax trifoliatus leaf extract, the agave stem extract, the perilla frutescens extract, the soybean polypeptide and other components is adopted, such that the skin can be deeply cleaned and moistened, and the multiple functions of inflammation resistance, allergy prevention and aging resistance are provided. In addition, the aloe barbadensis leaf extract provides moisturizing and soothing functions, PEG-6 caprylic acid / caprin promotes permeation through emulsification and assists in removing stubborn cosmetics, the cactus extract enhances the hydration of cuticles to improve mild permeation of makeup removing components, and the aloe barbadensis leaf extract, the PEG-6 caprylic acid / caprin and the cactus extract synergistically achieve efficient makeup removal, reduce irritation and maintain the skin barrier function at the same time.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and relates to a penetration-promoting composition, a preparation method thereof, and application in makeup remover. Background Art

[0002] Makeup removal plays a vital role as the first step in the skin care routine. Makeup residue on the face, especially oily makeup, can be regarded as a kind of oily dirt. If this dirt is not removed in time, it will clog the pores and prevent skin cells from breathing smoothly. When the breathing of cells is blocked, the metabolism function of the skin will also be affected, which will cause a series of skin problems. If makeup is not removed thoroughly for a long time, the skin will gradually lose its original delicate texture and become rough, and the pores will become more and more obvious and even expand. In addition, the skin color may become dull and lose its luster. At the same time, due to clogged pores, dark particles and acne are prone to grow on the skin surface. In order to deal with these makeup removal problems, a variety of makeup removal products are provided on the market, including makeup remover water, makeup remover milk, makeup remover oil and makeup remover cream, etc. They have their own characteristics and can meet different skin types and makeup removal needs.

[0003] The Chinese patent with publication number CN107898663A discloses a moisturizing makeup remover and a preparation method thereof, wherein peel and water are placed in a beaker, and the beaker is placed in a digital display speed measurement constant temperature magnetic stirrer, heated and stirred to mix, a mixed solution is obtained, and then the mixed solution is filtered to obtain a peel extract solution; surfactant, carbomer, keratinase, water, plant essential oil, ethanol solution, frankincense, aloe juice, preservative, and peel extract solution are ultrasonically dispersed to obtain a dispersion solution, and the dispersion solution is placed in an incubator and cultured at a constant temperature to obtain a pre-treated mixture solution; the mixture is placed in a vertical electric field and polarized to obtain a moisturizing makeup remover. The moisturizing makeup remover provided by the present invention has an excellent makeup removal effect and has a long-lasting moisturizing effect.

[0004] However, most of the makeup removers in the prior art have only a single function, and only have the basic functions of promoting penetration, cleaning, and moisturizing, which is far from enough to meet the growing needs of consumers. Summary of the invention

[0005] The purpose of the present invention is to provide a penetration-promoting composition, a preparation method thereof and application in makeup remover. The present invention uses a composite formula and the components interact with each other, which can not only deeply clean and moisturize the skin, but also have multiple functions of anti-inflammatory, anti-allergic and anti-aging.

[0006] The purpose of the present invention can be achieved through the following technical solutions:

[0007] A penetration-promoting composition comprises the following components by weight:

[0008]

[0009] As a preferred technical solution of the present invention, the penetration-promoting composition further comprises the following components by weight: 4-6 parts of moisturizer A, 3.5-4.2 parts of emulsifier, 2.8-3.4 parts of surfactant, 1.8-2.2 parts of skin conditioner A, 0.38-0.42 parts of preservative A, 0.13-0.16 parts of preservative B, 0.09-0.12 parts of skin conditioner B, 0.010-0.012 parts of moisturizer B and 88-95 parts of solvent.

[0010] As a preferred technical solution of the present invention, the preparation of the balsam pear leaf extract includes: drying, crushing, extracting, filtering and rotary evaporation of the balsam pear leaves, the extraction solvent is 80% volume concentration of n-butanol aqueous solution, the extraction time is 60-80min, the extraction temperature is 62-68°C, and the solid-liquid ratio is 1g:15-20mL; wherein, the preparation parameters of the balsam pear leaf extract in the embodiment and the comparative example are the extraction time of 70min, the extraction temperature of 65°C, and the solid-liquid ratio of 1g:20mL.

[0011] As a preferred technical solution of the present invention, the terpenes contained in the balsam pear leaf extract have strong permeation-promoting ability and low toxicity, can improve skin permeability, and have a permeation-promoting effect on both hydrophilic and lipophilic drugs. It can also reduce the release of inflammatory factors by regulating the NF-κB signaling pathway, thereby indirectly improving the permeability of the skin barrier.

[0012] As a preferred technical solution of the present invention, agave extract can form a competitive bond with keratin, weaken the hydration enhancement of the hydrogen bond network of the stratum corneum, form a co-permeation system with propylene glycol, and significantly improve the permeability coefficient of lipophilic components.

[0013] As a preferred technical solution of the present invention, the moisturizer A is propylene glycol; the emulsifier is PEG-6 caprylic / capric glyceride.

[0014] As a preferred technical solution of the present invention, the surfactant is composed of cocamidopropyl betaine, sodium benzoate and deionized water in a mass ratio of 61-64:37-39:0.4-0.5.

[0015] As a preferred technical solution of the present invention, the skin conditioner A is a mixture of aloe vera leaf juice, lactobacillus fermentation product, 1,2-hexanediol, cactus extract and p-hydroxyacetophenone in a mass ratio of 50:48.2:1.0:0.5:0.3.

[0016] As a preferred technical solution of the present invention, the lactobacillus fermentation product is a product obtained by culturing and fermenting lactobacillus in a milk culture medium and removing impurities; the cactus extract and the lactobacillus fermentation product are mixed, and then aloe vera leaf juice is added and fermented for 12 hours, sterilized, and 1,2-hexanediol and p-hydroxyacetophenone are added to obtain the skin conditioner A.

[0017] As a preferred technical solution of the present invention, preservative A is phenoxyethanol; and preservative B is chlorphenesin.

[0018] As a preferred technical solution of the present invention, the skin conditioning agent B is allantoin; the moisturizing agent B is sodium hyaluronate; and the solvent is deionized water.

[0019] As a preferred technical solution of the present invention, a preparation method of a penetration-promoting composition comprises the following steps: pre-dissolving preservative B and 1 / 3 moisturizer A uniformly to obtain a mixed solution; adding the solvent, the remaining moisturizer A, the skin conditioner B, and the moisturizer B into an emulsifying pot, stirring at 25-35r / min and heating to 80-85°C, then adding the mixed solution to keep warm and sterilize for 20 minutes, cooling to 40-45°C, adding balsam pear leaf extract, agave stem extract, perilla extract and soybean polypeptide, stirring for 45-60 minutes, adding emulsifier, surfactant, skin conditioner A and preservative A, stirring at 25-35r / min for 10-20 minutes, filtering through a 300-mesh sieve and discharging.

[0020] As a preferred technical solution of the present invention, a penetration-promoting composition as described above is used in makeup remover.

[0021] Beneficial effects of the present invention:

[0022] The present invention uses a composite formula composed of ingredients such as balsam pear leaf extract, agave stem extract, perilla extract and soybean peptide, which interact with each other to produce unexpected positive effects. It can not only deeply cleanse and moisturize the skin, but also has multiple functions of anti-inflammatory, anti-allergic and anti-aging. The makeup remover made based on this formula not only inherits the penetration and cleansing and moisturizing properties of traditional makeup remover products, but also adds the ability to comprehensively improve skin quality. DETAILED DESCRIPTION

[0023] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0024] Example 1

[0025] A penetration-promoting composition comprises the following components by weight:

[0026] 2 parts of balsam pear leaf extract, 3.0 parts of agave stem extract, 1.0 part of perilla extract, 0.6 parts of soybean polypeptide, 4 parts of humectant A, 3.5 parts of emulsifier, 2.8 parts of surfactant, 1.8 parts of skin conditioner A, 0.38 parts of preservative A, 0.13 parts of preservative B, 0.09 parts of skin conditioner B, 0.010 parts of humectant B and 88 parts of solvent.

[0027] Among them, the moisturizer A is propylene glycol; the emulsifier is PEG-6 caprylic / capric glyceride; the surfactant is composed of cocamidopropyl betaine, sodium benzoate and deionized water in a mass ratio of 61:37:0.4; the skin conditioner A is a mixture of aloe vera leaf juice, lactobacillus fermentation product, 1,2-hexanediol, cactus extract and parahydroxyacetophenone in a mass ratio of 50:48.2:1.0:0.5:0.3; the preservative A is phenoxyethanol; the preservative B is chlorphenesin; the skin conditioner B is allantoin; the moisturizer B is sodium hyaluronate; and the solvent is deionized water.

[0028] A method for preparing a penetration-promoting composition comprises the following steps:

[0029] Pre-dissolve preservative B and 1 / 3 moisturizer A evenly to obtain a mixed solution; add the solvent, the remaining moisturizer A, skin conditioner B, and moisturizer B into an emulsifier, stir, heat to 80°C at 25r / min, then add the mixed solution and sterilize it for 20 minutes. After cooling to 40°C, add balsam pear leaf extract, agave stem extract, perilla extract and soybean polypeptide and stir for 45 minutes. Then add emulsifier, surfactant, skin conditioner A and preservative A and stir at 25r / min for 10 minutes. Filter through a 300-mesh sieve and discharge the material.

[0030] Example 2

[0031] A penetration-promoting composition comprises the following components by weight:

[0032] 3 parts of balsam pear leaf extract, 3.8 parts of agave stem extract, 1.3 parts of perilla extract, 0.8 parts of soybean polypeptide, 5 parts of moisturizer A, 3.8 parts of emulsifier, 3.1 parts of surfactant, 2 parts of skin conditioner A, 0.4 parts of preservative A, 0.15 parts of preservative B, 0.1 parts of skin conditioner B, 0.011 parts of moisturizer B and 92 parts of solvent.

[0033] Wherein, the moisturizer A is propylene glycol; the emulsifier is PEG-6 caprylic acid / capric acid glyceride; the surfactant is composed of cocamidopropyl betaine, sodium benzoate and deionized water in a mass ratio of 62:38:0.45;

[0034] The skin conditioning agent A is prepared by mixing aloe vera leaf juice, lactobacillus fermentation product, 1,2-hexanediol, cactus extract and p-hydroxyacetophenone in a mass ratio of 50:48.2:1.0:0.5:0.3; the preservative A is phenoxyethanol; the preservative B is chlorphenesin; the skin conditioning agent B is allantoin; the moisturizer B is sodium hyaluronate; and the solvent is deionized water.

[0035] A method for preparing a penetration-promoting composition comprises the following steps:

[0036] Preservative B and 1 / 3 moisturizer A are uniformly dissolved in advance to obtain a mixed solution; the solvent, the remaining moisturizer A, skin conditioner B, and moisturizer B are added into an emulsifier, stirred at 30 r / min, heated to 82°C, and then the mixed solution is added and sterilized for 20 minutes. After cooling to 42°C, balsam pear leaf extract, agave stem extract, perilla extract and soybean polypeptide are added and stirred for 52 minutes, and then emulsifier, surfactant, skin conditioner A and preservative A are added and stirred at 30 r / min for 15 minutes, and the material is discharged after filtering through a 300-mesh sieve.

[0037] Example 3

[0038] A penetration-promoting composition comprises the following components by weight:

[0039] 4 parts of balsam pear leaf extract, 4.5 parts of agave stem extract, 1.6 parts of perilla extract, 0.9 parts of soybean polypeptide, 6 parts of moisturizer A, 4.2 parts of emulsifier, 3.4 parts of surfactant, 2.2 parts of skin conditioner A, 0.42 parts of preservative A, 0.16 parts of preservative B, 0.12 parts of skin conditioner B, 0.012 parts of moisturizer B and 95 parts of solvent.

[0040] Wherein, the moisturizer A is propylene glycol; the emulsifier is PEG-6 caprylic / capric glyceride; the surfactant is composed of cocamidopropyl betaine, sodium benzoate and deionized water in a mass ratio of 64:39:0.5;

[0041] The skin conditioning agent A is prepared by mixing aloe vera leaf juice, lactobacillus fermentation product, 1,2-hexanediol, cactus extract and p-hydroxyacetophenone in a mass ratio of 50:48.2:1.0:0.5:0.3; the preservative A is phenoxyethanol; the preservative B is chlorphenesin; the skin conditioning agent B is allantoin; the moisturizer B is sodium hyaluronate; and the solvent is deionized water.

[0042] A method for preparing a penetration-promoting composition comprises the following steps:

[0043] Pre-dissolve preservative B and 1 / 3 moisturizer A evenly to obtain a mixed solution; add the solvent, the remaining moisturizer A, skin conditioner B, and moisturizer B into an emulsifier, stir, heat to 85°C at 35r / min, then add the mixed solution and sterilize it for 20 minutes. After cooling to 45°C, add balsam pear leaf extract, agave stem extract, perilla extract and soybean polypeptide and stir for 60 minutes. Then add emulsifier, surfactant, skin conditioner A and preservative A and stir at 35r / min for 20 minutes. Filter through a 300-mesh sieve and discharge the material.

[0044] Comparative Examples 1-4

[0045] Compared with Example 3, the difference in Comparative Examples 1-4 is that the amounts of the balsam pear leaf extract, the agave stem extract, the perilla extract and the soybean polypeptide are as shown in Table 1;

[0046] Table 1 (Unit: parts by weight)

[0047]

[0048] The remaining components, preparation steps and parameters were the same.

[0049] Test Example 1

[0050] 70 volunteers aged between 30 and 45 with dry skin problems were selected, including 35 males and 35 females. These volunteers were randomly assigned to 7 groups, each containing 10 volunteers. The composition was soaked in non-woven fabrics, and the facial area of ​​the volunteers was used as the test area, and applied to the corresponding test samples. The volunteers were required to apply the samples to the facial area once a day in the morning and evening, each time for 1 minute, for 14 days.

[0051] On the 0th and 14th days of product use, the skin moisture content of the participants was measured using the Corneometer CM825 skin moisture tester. The moisturizing properties of different samples were evaluated by analyzing the changes in data before and after using the product. The results are shown in Table 2.

[0052] Table 2

[0053]

[0054]

[0055] As can be seen from Table 2, the compositions of Examples 1-3 of the present invention can effectively maintain moisture on the skin surface, and combined with the effect of the moisturizing ingredients, effectively prevent the loss of skin moisture, thereby achieving the purpose of moisturizing. In contrast, the compositions of Comparative Examples 1-4 are less effective in maintaining moisture on the skin surface.

[0056] Test Example 2

[0057] 80 mice weighing 20±2 grams were selected, half of them were male and half were female, and they were randomly divided into groups after one week of feeding. One group used physiological saline as a control, and the rest were divided into an embodiment group and a comparative example group. All compounds were dissolved in sterile water to prepare a 30 mg / ml solution. At the beginning of the experiment, 0.05 mL of xylene was applied to the right ear of each mouse, and 0.05 mL of the corresponding composition was applied 30 minutes later, and the left ear was used as a control. After 120 minutes, the mice were killed, and both ears were weighed to calculate the ear swelling rate;

[0058] Ear swelling rate = (right ear weight - left ear weight) / left ear weight × 100%;

[0059] The results are shown in Table 3.

[0060] Table 3

[0061] Ear swelling rate (%) Example 1 10.2 Example 2 9.6 Example 3 9.8 Comparative Example 1 16.8 Comparative Example 2 15.2 Comparative Example 3 16.3 Comparative Example 4 14.9 Negative control group 19.4

[0062] It can be seen from Table 3 that the compositions of Examples 1-3 of the present invention can effectively inhibit inflammation. In contrast, the compositions of Comparative Examples 1-4 have poor anti-inflammatory effects.

[0063] From the results in Table 2 and Table 3, combined with the examples and comparative examples, it can be seen through comparative analysis that the agave leaf extract used in the present invention is rich in agave leaf flavonoids, can regulate the expression of mitogen-activated protein kinase and nuclear transcription factor NF-κB, and has significant anti-inflammatory, analgesic and anti-allergic effects. The agave stem extract contains factors that inhibit free histamine. Soybean polypeptides can form a skin barrier by supplementing the amino acids and proteins required by the skin. The polyphenols contained in the perilla extract can inhibit substances that cause allergies and inflammation, and the α-linolenic acid contained in it can combine with soybean polypeptides to have a strong inhibitory effect on inflammation. These four have a significant synergistic effect in resisting skin allergies.

[0064] Some specific amino acid sequences contained in soybean peptides can stimulate the activity of skin cells and promote the synthesis of collagen and elastin, while agave stem extract contains a large number of factors that inhibit elastase and collagenase, thereby preventing the loss of the above-mentioned collagen. Perilla extract increases the activity of skin SOD and reduces MDA levels. Basilicum contains flavonoids, polysaccharides and other ingredients that can scavenge free radicals and act as an antioxidant. Therefore, the combination of the four has a synergistic effect of excellent moisturizing and anti-aging effects.

[0065] In addition, PEG-6 caprylic / capric glycerides, as nonionic surfactants, temporarily reduce barrier resistance by interfering with the lipid arrangement of the stratum corneum, promote the penetration of hydrophilic / lipophilic ingredients, enhance formula stability, help disperse insoluble active ingredients, and indirectly improve penetration efficiency.

[0066] Aloe barbadensis leaves contain polysaccharides (such as acetylated mannan) and amino acids, which indirectly promote the penetration of small molecules by moisturizing and softening the stratum corneum. Anti-inflammatory soothing ingredients (such as aloin) can reduce the irritation that may be caused by penetration enhancers and improve the mildness of the formula. It can also be used as a "moisturizing soothing agent" and is suitable for sensitive skin lotions to relieve dryness and redness. Aloe barbadensis leaf extract can synergize with PEG-6 glyceride to reduce its potential irritation.

[0067] Cactus extract contains mucilage polysaccharides and antioxidant flavonoids, which extend the residence time of active ingredients by forming a hydrophilic film and promote slow penetration. It enhances skin hydration and indirectly improves penetration efficiency. As a "natural moisturizing enhancer", cactus extract can effectively enhance the antioxidant and anti-pollution effects when used in combination with aloe vera leaf extract.

[0068] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any indirect modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A penetration-promoting composition, characterized in that The components include the following by weight: 2-4 parts of balsam pear leaf extract Agave stem extract 3.0-4.5 parts 1.0-1.6 parts of Perilla extract 0.6-0.9 parts of soybean peptides.

2. A penetration-promoting composition according to claim 1, characterized in that, The following components are also included by weight: 4-6 parts of moisturizing agent A, 3.5-4.2 parts of emulsifier, 2.8-3.4 parts of surfactant, 1.8-2.2 parts of skin conditioning agent A, 0.38-0.42 parts of preservative A, 0.13-0.16 parts of preservative B, 0.09-0.12 parts of skin conditioning agent B, 0.010-0.012 parts of moisturizing agent B and 88-95 parts of solvent.

3. A penetration-promoting composition according to claim 2, characterized in that: The moisturizer A is propylene glycol; the emulsifier is PEG-6 caprylic / capric glycerides.

4. A penetration-promoting composition according to claim 2, characterized in that: The surfactant is composed of cocamidopropyl betaine, sodium benzoate and deionized water in a mass ratio of 61-64:37-39:0.4-0.

5.

5. A penetration-promoting composition according to claim 2, characterized in that: The skin conditioning agent A is prepared by mixing aloe vera leaf juice, lactobacillus fermentation product, 1,2-hexanediol, cactus extract and p-hydroxyacetophenone in a mass ratio of 50:48.2:1.0:0.5:0.

3.

6. A penetration-promoting composition according to claim 2, characterized in that: The preservative A is phenoxyethanol; the preservative B is chlorphenesin.

7. A penetration-promoting composition according to claim 2, characterized in that: The skin conditioning agent B is allantoin; the moisturizing agent B is sodium hyaluronate; and the solvent is deionized water.

8. A method for preparing the penetration-promoting composition according to any one of claims 2 to 7, characterized in that: The preparation method comprises the following steps: pre-dissolving preservative B and 1 / 3 moisturizing agent A uniformly to obtain a mixed solution; adding solvent, remaining moisturizing agent A, skin conditioner B and moisturizing agent B into an emulsifying pot, stirring, heating to 80-85°C at 25-35r / min, adding the mixed solution to keep warm and sterilize for 20min, cooling to 40-45°C, adding balsam pear leaf extract, agave stem extract, perilla extract and soybean polypeptide, stirring for 45-60min, adding emulsifier, surfactant, skin conditioner A and preservative A, stirring at 25-35r / min for 10-20min, filtering through a 300-mesh sieve and discharging.

9. Use of the penetration-promoting composition according to any one of claims 1 to 7 in makeup remover.

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