Composition and essence lotion with whitening and skin tendering effects as well as preparation method and application of composition and essence lotion

Abstract

The invention relates to a composition with whitening and skin tendering effects, essence lotion and a preparation method and application of the essence lotion, in the composition with the whitening and skin tendering effects, the weight ratio of achillea millefolium extract to hydroxyethyl piperazine ethanesulfonic acid to ormosia henryi bark extract is (0.1-1): (0.5-8): (0.05-0.5). The essence lotion is prepared from the following components in percentage by weight: 0.75 to 6 percent of composition with skin whitening and tendering effects, 3 to 8 percent of emollient, 0.5 to 2 percent of emulsifier, 0.01 to 1 percent of filler, 0.5 to 2 percent of thickener, 0.8 to 1.5 percent of preservative, 0.02 to 0.2 percent of daily essence, 0.1 to 10 percent of skin conditioner, 0.1 to 10 percent of humectant and the balance of deionized water. The main components have a synergistic effect, can effectively regulate and control the information network effect of endothelin and reduce the differentiation, proliferation and the like of melanocytes in the first step of melanin generation by inhibiting the activity of tyrosinase, can promote cell autophagy and effectively metabolize melanin and lipofuscin generated in the skin, and achieves the effects of whitening, whitening, whitening and the like. The skin tendering effect is realized.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemicals, in particular to a composition with skin whitening and rejuvenation effects, an essence milk, and a preparation method and application thereof. Background Art

[0002] Whitening cosmetics have always been the focus of attention of consumers and cosmetics manufacturers.

[0003] There are countless products on the market that claim to whiten and rejuvenate the skin. However, the whitening agents in these products are mainly kojic acid, vitamin C derivatives, phenylethyl resorcinol, etc., and they all achieve the whitening purpose through a single mechanism or a combination of several mechanisms. The functional effects of these products when used in cosmetics are often unsatisfactory, or the raw materials themselves have certain shortcomings, such as the raw materials are unstable, or difficult to add to the formula system, or easy to change color, or too irritating to the skin.

[0004] Currently, the commonly used penetration enhancer is azone, which increases the diffusion and penetration of active ingredients by dissolving stratum corneum lipids or liquefying lipids in keratinocytes. It is highly destructive to the stratum corneum. Long-term use will cause the loss of sebum membrane and damage the stratum corneum barrier function. Therefore, how to find a safe and effective formula with both whitening function and penetration effect has become a difficulty in the existing technology.

[0005] Chinese patent CN118319820B discloses a composition with skin whitening and lightening effects and its preparation method. It includes component A and component B; the component A includes purple sweet potato red powder and water, and the pH value of the component A is 2.5-3; the component B includes water-soluble tender red pigment, yarrow extract, rhodiola rosea extract, glacier water and water, and the pH value of the component B is 5-7. The synergistic combination of the components has excellent skin whitening and lightening effects, and the overall appearance is "white and red", and the above composition has little irritation to the skin and excellent anti-allergic effect. However, the ingredients in this solution are complex, including purple sweet potato red powder, water-soluble tender red pigment, yarrow extract, rhodiola rosea extract, etc. The ingredients are complex, and it does not pay attention to the skin penetration effect.

[0006] Chinese patent CN114588068B discloses a composition with skin whitening and spot-lightening effects, and discloses the use of a combination of tranexamic acid, ascorbyl glucoside, nicotinamide and hydroxyethylpiperazineethane sulfonic acid in preparing a composition with skin whitening and spot-lightening effects. The combination of tranexamic acid, ascorbyl glucoside, nicotinamide and hydroxyethylpiperazineethane sulfonic acid is added to a pharmaceutical composition or a cosmetic composition, which can effectively reduce the amount of melanin generated in the skin, improve skin pigmentation, and achieve the effects of skin whitening and brightening. However, the composition mainly uses tranexamic acid, ascorbyl glucoside and nicotinamide to achieve the effects of whitening and brightening, and tranexamic acid and nicotinamide have certain skin irritation problems. Summary of the invention

[0007] The prior art lacks a formula having both skin whitening and skin rejuvenation functions and a penetrating effect. Based on this, the present invention provides a composition having skin whitening and skin rejuvenation effects, an essence lotion, and a preparation method and application thereof.

[0008] The composition with skin whitening and skin rejuvenation effects provided by the present invention has synergistic effects among the main ingredients, can inhibit tyrosinase activity, and effectively inhibit melanin production from the source in the first step of melanin production, thereby effectively inhibiting the binding of endothelin to melanocyte receptors, thereby effectively regulating the information network effect of endothelin, reducing the differentiation and proliferation of melanocytes, etc., and can promote cell autophagy, and can effectively metabolize the melanin and lipofuscin already produced in the skin, thereby achieving the effect of skin whitening and skin rejuvenation.

[0009] The purpose of the present invention can be achieved by the following technical solutions:

[0010] The present invention first provides a composition with skin whitening and skin rejuvenation effects, comprising the following components: yarrow (ACHILLEA MILLEFOLIUM) extract, hydroxyethylpiperazine ethane sulfonic acid, and Pterocarpus marsupialis (Pterocarpus marsupialis) bark extract, and the weight ratio of the yarrow (ACHILLEA MILLEFOLIUM) extract, hydroxyethylpiperazine ethane sulfonic acid, and Pterocarpus marsupialis (Pterocarpus marsupialis) bark extract is (0.1-1): (0.5-8): (0.05-0.5).

[0011] In one embodiment of the present invention, in the composition with skin whitening and rejuvenation effects, the mass ratio of the yarrow (ACHILLEA MILLEFOLIUM) extract, hydroxyethylpiperazineethane sulfonic acid, and Pterocarpus marsupium bark extract is (0.2-0.8): (0.5-5): (0.05-0.3).

[0012] The present invention further provides application of the composition with skin whitening and skin rejuvenation effects in the preparation of skin care products or cosmetics.

[0013] In one embodiment of the present invention, the skin care product or cosmetic is in the form of solvent dispersion or suspension, or in the form of emulsified particles, or in the form of polymer encapsulation.

[0014] In one embodiment of the present invention, the skin care products or cosmetics can be any form of skin care products or cosmetics, including lotions, creams, freeze-dried powders, skin care water, essences, etc. The skin care products or cosmetics have the effect of whitening and rejuvenating the skin.

[0015] The present invention also provides a skin care product or cosmetic with skin whitening and skin rejuvenation effects, comprising a matrix auxiliary material and an effective component, wherein the effective component is a composition with skin whitening and skin rejuvenation effects. The auxiliary material is selected from one or a combination of emollients, emulsifiers, fillers, thickeners, preservatives, skin conditioners, moisturizers or fragrances.

[0016] In one embodiment of the present invention, the emollient is selected from one or more of behenyl alcohol, cetyl alcohol, caprylic capric triglyceride, squalane, LIMNANTHES ALBA seed oil, shea butter, jojoba esters, olive oil, dimethicone, dimethiconol, isohexadecane, coconut oil-caprylate / caprate or isononyl isononanoate.

[0017] In one embodiment of the present invention, the emulsifier is selected from one or more of polyglyceryl-3 methyl glucose distearate, polyglyceryl-6 distearate, polyglyceryl-3 beeswax acid ester, potassium cetyl phosphate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, steareth-21, cetearyl alcohol, cetearyl glucoside, glyceryl stearate or PEG-100 stearate.

[0018] In one embodiment of the present invention, the filler is selected from one or more of boron nitride, synthetic fluorphlogopite, cellulose acetate or starch octyl aluminum succinate;

[0019] In one embodiment of the present invention, the thickener is selected from one or more of carbomer, xanthan gum, acrylates / C10-30 alkyl acrylate cross-linked polymer, gum arabic, sodium acrylate / sodium acryloyldimethyl taurate, acrylates / C10-30 alkyl acrylate cross-linked polymer copolymer, hydroxyethyl cellulose or hectorite.

[0020] In one embodiment of the present invention, the preservative is selected from one or more of phenoxyethanol, ethylhexylglycerin, phenoxyethanol, sodium benzoate, pentylene glycol or hexylene glycol.

[0021] In one embodiment of the present invention, the skin conditioning agent is selected from one or more of isohexadecane, sodium hyaluronate, lauryl alcohol, avocado butter, allantoin, squalane, panthenol, lactic acid, tocopherol or dipotassium glycyrrhizinate.

[0022] In one embodiment of the present invention, the moisturizing agent is selected from one or more of hyaluronic acid, glycerin, ceramide, sodium lactate, butylene glycol, and hydrogenated grape seed oil.

[0023] In one embodiment of the present invention, the fragrance comprises essence.

[0024] In some preferred embodiments, based on 100 parts by weight of the total weight of the skin care product or cosmetic, the composition with skin whitening and skin rejuvenation effects is 0.65 to 9.5 parts, preferably 0.75 to 6 parts.

[0025] The present invention also provides an essence milk with a composition having whitening and skin rejuvenation effects. Taking the total weight of the essence milk as 100%, the essence milk comprises the following components in weight percentage: 0.75-6% of the composition having whitening and skin rejuvenation effects, 3-8% of a moisturizer, 0.5-2% of an emulsifier, 0.01-1% of a filler, 0.5-2% of a thickener, 0.8-1.5% of a preservative, 0.02-0.2% of a fragrance, 0.1-10% of a skin conditioner, 0.1-10% of a humectant, and the balance being deionized water.

[0026] In one embodiment of the present invention, the emollient is selected from one or more of behenyl alcohol, cetyl alcohol, caprylic capric triglyceride, squalane, LIMNANTHES ALBA seed oil, shea butter, jojoba esters, olive oil, dimethicone, dimethiconol, isohexadecane, coconut oil-caprylate / caprate or isononyl isononanoate.

[0027] In one embodiment of the present invention, the emulsifier is selected from one or more of polyglyceryl-3 methyl glucose distearate, polyglyceryl-6 distearate, polyglyceryl-3 beeswax acid ester, potassium cetyl phosphate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, steareth-21, cetearyl alcohol, cetearyl glucoside, glyceryl stearate or PEG-100 stearate.

[0028] In one embodiment of the present invention, the filler is selected from one or more of boron nitride, synthetic fluorphlogopite, cellulose acetate or starch octyl aluminum succinate;

[0029] In one embodiment of the present invention, the thickener is selected from one or more of carbomer, xanthan gum, acrylates / C10-30 alkyl acrylate cross-linked polymer, gum arabic, sodium acrylate / sodium acryloyldimethyl taurate, acrylates / C10-30 alkyl acrylate cross-linked polymer copolymer, hydroxyethyl cellulose or hectorite.

[0030] In one embodiment of the present invention, the preservative is selected from one or more of phenoxyethanol, ethylhexylglycerin, phenoxyethanol, sodium benzoate, pentylene glycol or hexylene glycol.

[0031] In one embodiment of the present invention, the skin conditioning agent comprises allantoin.

[0032] In one embodiment of the present invention, the moisturizing agent comprises sodium hyaluronate.

[0033] In one embodiment of the present invention, the fragrance comprises essence.

[0034] The present invention further provides a method for preparing the essence milk having the whitening and skin rejuvenation effect composition, comprising the following steps:

[0035] 1) Disperse the thickener completely in deionized water to obtain a mixed solution, continue to add the moisturizer, stir evenly and set aside;

[0036] 2) adding emollient, filler and emulsifier to the mixed solution in step 1), heating to 80-85° C., and homogenizing at 2000-3500 r / min for 3-5 minutes to completely emulsify the mixture;

[0037] 3) Cooling to 43-45° C. Adding preservatives, skin conditioners, a composition with skin whitening and skin rejuvenation effects, and fragrances to the mixed solution obtained in step 2) to obtain an essence lotion with a composition with skin whitening and skin rejuvenation effects.

[0038] Compared with the prior art, the present invention has the following beneficial effects:

[0039] 1. The present invention selects yarrow (ACHILLEA MILLEFOLIUM) extract, hydroxyethylpiperazine ethane sulfonic acid, and Pterocarpus marsupialis (Pterocarpus marsupialis) bark extract as whitening and skin rejuvenation effective ingredients. The three ingredients work synergistically to inhibit tyrosinase activity, thereby effectively inhibiting melanin production from the source at the first step of melanin production, and effectively inhibiting the binding of endothelin to melanocyte receptors, thereby effectively regulating the information network function of endothelin, reducing the differentiation and proliferation of melanocytes, and promoting cell autophagy, effectively metabolizing the melanin and lipofuscin already produced in the skin, and achieving the effects of whitening, brightening and skin rejuvenation.

[0040] 2. In the composition with skin whitening and skin rejuvenation effect provided by the present invention, hydroxyethylpiperazine ethane sulfonic acid is used as the effective ingredient, and hydroxyethylpiperazine ethane sulfonic acid has the effect of softening keratin and instantly brightening the skin color. Hydroxyethylpiperazine ethane sulfonic acid is rated as 1 by the U.S. EWG (Environmental Working Group) and is a green-grade safety ingredient. It is safe for the human body, non-toxic, has good physiological compatibility, and has very stable chemical properties. Compared with azone-type penetration enhancers, it has the advantages of short onset time, small dosage, and high penetration rate. DETAILED DESCRIPTION

[0041] The present invention is described in detail below with reference to specific embodiments.

[0042] The present invention discloses a composition with skin whitening and rejuvenation effects, an essence lotion, a preparation method and application thereof. The main functional ingredients of the composition with skin whitening and rejuvenation effects include: yarrow (ACHILLEA MILLEFOLIUM) extract, hydroxyethylpiperazineethane sulfonic acid, and Pterocarpus marsupialis (Pterocarpus marsupialis) bark extract.

[0043] Among them, the extract of ACHILLEA MILLEFOLIUM mainly upregulates small molecule HSPS to enhance skin health, while protecting cell vitality under heat stress exposure and resisting damage to proteins caused by pollutants. On the other hand, it has the effects of combating ROS, inhibiting tyrosinase and photoprotection, ultimately achieving the goal of enhancing facial radiance, brightening skin tone and improving skin appearance.

[0044] Hydroxyethylpiperazine ethane sulfonic acid can penetrate deep into the intercellular lipids, temporarily open the channels, promote the penetration effect of water-soluble active ingredients, and reduce the solubility of water-soluble ingredients, so that they can better enter the stratum corneum and synergize with the effective ingredients.

[0045] Pterocarpus marsupium bark extract is a unique autophagy inducer that can effectively induce cytoprotective autophagy in human umbilical vein endothelial cells by rapidly increasing intracellular calcium concentration and activation of AMPKa1, thereby inhibiting the negative regulator of autophagy, mTOR, and inhibiting melanin production by down-regulating proteins involved in B16-F10 cells triggered by α-MSH. It can also induce anti-melanin production through autophagy, inhibit the expression of COX-2, iNOS, PGE2 and NO through the Nrf2 pathway, reduce the degree of inflammation, and down-regulate the inflammatory response and ROS (reactive oxygen species) in cells. In addition to its role in scavenging ROS, it also has an inhibitory effect on the activation of neutrophils, the production of inflammatory mediators and the apoptosis of endothelial cells, achieving all-round and efficient whitening.

[0046] The present invention innovatively combines several effective ingredients together to multiply the effects. By inhibiting tyrosinase activity, it can effectively inhibit melanin production from the source at the first step of melanin production, and can effectively inhibit the binding of endothelin to melanocyte receptors, thereby effectively regulating the information network function of endothelin, reducing the differentiation and proliferation of melanocytes, etc., and can promote cell autophagy, effectively metabolize the melanin and lipofuscin already produced in the skin, and achieve the effects of whitening, brightening and rejuvenating the skin.

[0047] The present invention is described below with reference to some specific embodiments. These embodiments are only used to further illustrate the present invention, and are not used to limit the present invention, and do not represent a limitation on the protection scope of the present invention. Some non-essential modifications and adjustments made by others based on the present invention still fall within the protection scope of the present invention. Unless otherwise specified, the following percentages (%) are all mass percentages.

[0048] Examples 1-3

[0049] Examples 1-3 provide essence milk with skin whitening and skin rejuvenation effects, and the content of the raw material components is shown in the following Table 1.

[0050] Table 1 Raw material composition ratio of Examples 1-3 (unit: mass %)

[0051]

[0052]

[0053]

[0054] The method for preparing the above-mentioned essence milk having skin whitening and skin rejuvenation effects comprises the following steps:

[0055] 1) Disperse the thickener completely in water to obtain a mixed solution, continue to add the moisturizer, stir evenly and set aside;

[0056] 2) adding emollient, filler and emulsifier to the mixed solution in step 1), heating to 80-85° C., and homogenizing at 2000-3500 r / min for 3-5 minutes to completely emulsify the mixture;

[0057] 3) Cooling to 43-45° C. Adding preservatives, skin conditioners, a composition with skin whitening and skin rejuvenation effects, and daily essence to step 2) to obtain an essence milk with skin whitening and skin rejuvenation effects.

[0058] The preparation process of blank example essence milk is as follows:

[0059] 1) Disperse the thickener completely in water to obtain a mixed solution, continue to add the moisturizer, stir evenly and set aside;

[0060] 2) adding emollient, filler and emulsifier to the mixed solution in step 1), heating to 80-85° C., and homogenizing at 2000-3500 r / min for 3-5 minutes to completely emulsify the mixture;

[0061] 3) Cooling to 43-45° C. Adding preservatives, skin conditioning agents, and daily fragrances to step 2) to obtain a blank example essence milk.

[0062] In order to verify the effects of the functional ingredients of the present invention, comparative examples 1-6 were set up. The following Table 2 shows the content of the raw material component ratios of the essence milks in comparative examples 1-6.

[0063] Table 2 Ratio of raw material components of comparative examples 1-6 (unit: mass %)

[0064]

[0065]

[0066]

[0067] The preparation method of the essence milk described in Comparative Examples 1-6 comprises the following steps:

[0068] 1) Disperse the thickener completely in water to obtain a mixed solution, continue to add the moisturizer, stir evenly and set aside;

[0069] 2) adding emollient, filler and emulsifier to the mixed solution in step 1), heating to 80-85° C., and homogenizing at 2000-3500 r / min for 3-5 minutes to completely emulsify the mixture;

[0070] 3) Cooling to 43-45° C. Adding preservatives, skin conditioners, a composition with skin whitening and skin rejuvenation effects, and daily essence to step 2) to obtain an essence milk with skin whitening and skin rejuvenation effects.

[0071] Effect verification test example

[0072] 1. Security Testing

[0073] Test samples: Examples 1-3 and Comparative Examples 1-6 and Blank Example

[0074] Test subjects: 100 subjects aged 20-50 were selected and randomly divided into 10 groups, with 10 people in each group.

[0075] Test method: Use a third-party testing agency to test safety. Select an area not exceeding 50mm 2 , a patch tester with a depth of about 1mm, and a closed patch test method, about 0.02-0.025ml (g) of the test substance (the essence milk of Examples 1-3, Comparative Examples 1-6 and the blank example) was added into the patch tester. The patch tester was attached to the curved side of the forearm of the subject, and the test substance was removed after 24 hours. The skin reaction was observed at 0.5h, 24h, and 48h after removal, and the results were recorded according to the skin reaction grading standards in the "Cosmetic Safety Technical Regulations 2015". The patch test results are shown in Table 3.

[0076] Table 3 Patch test results

[0077]

[0078]

[0079] Notes: Skin reaction grading standards;

[0080] Grade 0: negative reaction;

[0081] Grade 1: Suspicious reaction; only slight erythema;

[0082] Grade 2: weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present;

[0083] Grade 3: Strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, herpes; the reaction may extend beyond the test area;

[0084] Grade 4: Very strong reaction (confluent herpes reaction); obvious erythema, severe infiltration, edema, confluent herpes, and the reaction exceeds the test area.

[0085] The results showed that the products of Examples 1-3, Comparative Examples 1-6 and the blank example had a score of 0 at 30 minutes, 24 hours and 48 hours, and no adverse skin reactions occurred, indicating that the essence milk products of the present invention are safe and non-irritating to the skin.

[0086] 2. Stability test

[0087] Test samples: Examples 1-3;

[0088] Test method: Internal control standard: observe the appearance color and pH for three months:

[0089] A: No change; B: Very slight change, basically unnoticeable without standard sample comparison; C: Slight change, noticeable even without standard sample comparison; D: Obvious change, noticeable to consumers; E: Severe change,

[0090] The standard sample is a product placed at 25°C; the test results are shown in Table 4.

[0091] Table 4 Stability test results

[0092]

[0093]

[0094] In Table 4, W represents week, M represents month, and cycle represents -15°C to 50°C cycle.

[0095] As shown in Table 4 above, the essence milk prepared in Examples 1-3 has no significant changes in color, viscosity and pH within three months under high and low temperature conditions or under light exposure, which indicates that the essence milk of the present invention has good stability.

[0096] 3. Evaluation of the whitening effect of essence lotion

[0097] Test sample: Example 1;

[0098] Test method: Use the sample twice a day, morning and evening, for 8 weeks. Apply an appropriate amount of the test sample to one side of the face at random, and do not use the test sample on the other side of the face as a control. Apply sunscreen products to the entire face every morning.

[0099] The test results were collected at the following four time periods: before using the sample (D0), 14 days after using the sample (D14),

[0100] The sample was used for 28 days (D28) and for 56 days (D56).

[0101] The test items are:

[0102] 1) Skin melanin analyzer MX18 is used to detect skin melanin;

[0103] 2) Skin color measuring instrument CL200 is used to detect skin glossiness;

[0104] 3) Skin color measuring instrument CR400 is used to detect skin color.

[0105] Test results:

[0106] As shown in Table 5-6, the results of the clinical efficacy test of the test sample, the melanin of the target part of the subject was tested after 56 days of using the sample (the measured value decreases, indicating that the skin melanin content is less), the melanin value of the control area increased significantly by 4.60%, while the melanin of the area using the sample only increased by 1.89%. It shows that the prepared essence milk with whitening and skin rejuvenation effect can effectively reduce the production of skin melanin.

[0107] Table 5 Test results of skin melanin content in the sample group and the control group after 56 days

[0108] time Before use After 14 days of use After 28 days of use After 56 days of use sample 182.45 183.13 184.50 185.90 Comparison 183.87 185.38 187.77 192.33

[0109] Table 6 Change rate of skin melanin in the sample group and the control group after 56 days

[0110] time After 14 days of use After 28 days of use After 56 days of use sample 0.37％ 1.11％ 1.89％ Comparison 0.82％ 2.12％ 4.60％

[0111] Tables 7-8 show the results of the clinical efficacy test of the test samples. After 56 days of using the samples, the skin glossiness of the target parts of the subjects was tested (the increase in the measured value indicates that the skin glossiness is better). The skin glossiness value of the control area decreased by 6.71%, and the skin glossiness of the sample area increased by 2.73%, indicating that the prepared whitening and brightening skin rejuvenation essence lotion can effectively brighten the skin glossiness.

[0112] Table 7 Test results of skin glossiness of sample group and control group after 56 days

[0113] time Before use After 14 days of use After 28 days of use After 56 days of use sample 10.27 10.35 10.41 10.55 Comparison 10.28 10.11 9.89 9.59

[0114] Table 8 Change rate of skin glossiness of the sample group and the control group after 56 days

[0115] time After 14 days of use After 28 days of use After 56 days of use sample 0.78％ 1.36％ 2.73％ Comparison -1.65％ -3.79％ -6.71％

[0116] Tables 9-11 are the results of clinical evaluation by dermatologists:

[0117] 1) Dull skin color: 0 points indicate a dull, dark skin color, and 9 points indicate a bright skin color.

[0118] 2) Skin brightness: 0 points means the skin is not translucent and does not reflect light, and 10 points means the skin is translucent and reflects light.

[0119] 3) Skin fairness: 0 points means dark skin tone, while 9 points means very fair skin tone like porcelain.

[0120] Change rate = (measured value after using the sample - measured value before using the sample) / measured value before using the sample * 100%.

[0121] After the subjects used the samples for 56 days, the mean clinical score of skin dullness in the sample area increased significantly by 43.28%, and the mean clinical score of skin dullness in the control area increased significantly by 21.74%; the mean clinical score of skin brightness in the sample area increased significantly by 16.26%, and the mean clinical score of skin brightness in the control area increased significantly by 6.11%; the mean clinical score of skin whiteness in the sample area increased significantly by 35.17%, and the mean clinical score of skin whiteness in the control area increased significantly by 22.16%.

[0122] Table 9 Change rate of mean clinical score of skin dullness in sample group and control group after 56 days

[0123] time After 14 days of use After 28 days of use After 56 days of use sample 20.18％ 34.23％ 43.28％ Comparison 8.54％ 14.24％ 21.74％

[0124] Table 10 Change rate of mean clinical score of skin brightness in sample group and control group after 56 days

[0125] time After 14 days of use After 28 days of use After 56 days of use sample 21.14％ 31.23％ 16.26％ Comparison 8.49％ 17.14％ 6.11％

[0126] Table 11 Change rate of mean clinical score of skin whiteness in sample group and control group after 56 days

[0127] time After 14 days of use After 28 days of use After 56 days of use sample 18.15％ 27.66％ 35.17％ Comparison 7.87％ 18.43％ 22.16％

[0128] 4. Synergistic effect experiment of the main effective ingredients of essence milk

[0129] The efficacy of the essence milk of Example 1 and Comparative Examples 1-6 was verified (whitening evaluation), and the experimental steps and results are as follows:

[0130] 1. Testers: 70 healthy women (25-45 years old), divided into 7 groups, 10 people in each group; each group used the same formula product.

[0131] 2. Test area: face (blank sample on the left face, and the control sample on the right face is the essence lotion of Example 1 or Comparative Examples 1-6);

[0132] 3. Usage: Twice a day, morning and evening, for 4 weeks

[0133] 4. Test instrument: DelfinSkinColorCatch (Finland)

[0134] 5. Effect index: Determine the change in color brightness (ΔL * ), ITA degree, in the present invention, L * value (brightness), ITA degree (color

[0135] Color individual type angle), mainly used as an indicator.

[0136] Equation (1): ΔL * =[L * (One month after the product of Example 1 or Comparative Examples 1-6 was tested) * (Before the test of the products of Example 1 or Comparative Examples 1-6)]-[L * (Blank sample tested 1 month later) -L * (Blank sample before test)]

[0137]

[0138] (2): ITA degree (represents the overall change in chromaticity. The larger the ITA° value, the lighter the skin color.), as shown in Table 12 below.

[0139] Table 12 Skin color classification corresponding to different ITA° range values

[0140] ITA° Range Skin color classification 55-90 Very light 41-54 Light 28-40 Intermediate 10-27 Tanned -30-9 Brown -90--29 -29Dark

[0141]

[0142] 6. The test results are shown in Table 13 below.

[0143] Table 13 Whitening evaluation data of different embodiments and comparative examples

[0144]

[0145] From the results in Table 13, it can be seen that the whitening and brightening abilities are: Example 1 > Comparative Example 5 > Comparative Example 6 > Comparative Example 4 > Comparative Example 3 > Comparative Example 1 > Comparative Example 2.

[0146] The composition or essence milk with skin whitening and skin rejuvenation effects of the present invention has a relatively significant whitening and skin brightening and skin rejuvenation effect through the synergistic effect of various components, and is more obvious than the effect of a single whitening component or two of them used simultaneously. This is because the synergistic effect of the yarrow (ACHILLEA MILLEFOLIUM) extract, hydroxyethylpiperazine ethane sulfonic acid, and Pterocarpus marsupialis (Pterocarpus marsupialis) bark extract can effectively inhibit the generation of melanin from the source in the first step of melanin generation by inhibiting the activity of tyrosinase, and can effectively inhibit the binding of endothelin to melanocyte receptors, thereby effectively regulating the information network function of endothelin, reducing the differentiation and proliferation of melanocytes, etc., and can promote cell autophagy, effectively metabolize the melanin and lipofuscin already generated in the skin, and achieve the effects of whitening and skin brightening and skin rejuvenation.

[0147] The applicant declares that the present invention illustrates the essence milk and the preparation method thereof through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of the raw materials of the product of the present invention, addition of auxiliary ingredients, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims

1. A composition with skin whitening and skin rejuvenation effects, characterized in that: The invention comprises the following components: yarrow extract, hydroxyethylpiperazineethane sulfonic acid and tamarisk bark extract, and the weight ratio of the yarrow extract, hydroxyethylpiperazineethane sulfonic acid and tamarisk bark extract is (0.1-1): (0.5-8): (0.05-0.5).

2. The composition with skin whitening and skin rejuvenation effect according to claim 1, characterized in that: The mass ratio of the yarrow extract, hydroxyethylpiperazineethane sulfonic acid and the pterocarpus dasyphylla bark extract is (0.2-0.8): (0.5-5): (0.05-0.3).

3. Use of the composition with skin whitening and skin rejuvenation effect according to claim 1 or 2 in the preparation of skin care products or cosmetics.

4. A skin care product or cosmetic with skin whitening and skin rejuvenation effects, characterized in that: It comprises a matrix excipient and an effective component, wherein the effective component is the composition with skin whitening and skin rejuvenation effect as claimed in claim 1 or 2; The auxiliary material is selected from one or a combination of moisturizers, emulsifiers, fillers, thickeners, preservatives, skin conditioners, moisturizers, and fragrances.

5. An essence lotion with skin whitening and tenderizing effects, characterized in that: Taking the total weight of the essence milk as 100%, the essence milk comprises the following components in weight percentage: 0.75-6% of a composition with skin whitening and skin rejuvenation effects, 3-8% of a moisturizer, 0.5-2% of an emulsifier, 0.01-1% of a filler, 0.5-2% of a thickener, 0.8-1.5% of a preservative, 0.02-0.2% of a fragrance, 0.1-10% of a skin conditioner, 0.1-10% of a moisturizer, and the balance is deionized water.

6. The essence milk according to claim 5, characterized in that: The emollient is selected from one or more of behenyl alcohol, cetyl alcohol, caprylic capric triglyceride, squalane, Limnanthes Alba seed oil, shea butter, jojoba esters, olive oil, dimethicone, dimethiconol, isohexadecane, coconut oil alcohol-caprylate / caprate or isononyl isononanoate.

7. The essence milk according to claim 5, characterized in that: The emulsifier is selected from one or more of polyglyceryl-3 methyl glucose distearate, polyglyceryl-6 distearate, polyglyceryl-3 beeswax acid ester, potassium cetyl phosphate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, steareth-21, cetearyl alcohol, cetearyl glucoside, glyceryl stearate or PEG-100 stearate.

8. The essence milk according to claim 5, characterized in that: The filler is selected from one or more of boron nitride, synthetic fluorphlogopite, cellulose acetate or starch octyl aluminum succinate; The thickener is selected from one or more of carbomer, xanthan gum, acrylates / C10-30 alkyl acrylate cross-linked polymer, gum arabic, sodium acrylate / sodium acryloyldimethyl taurate, acrylates / C10-30 alkyl acrylate cross-linked polymer copolymer, hydroxyethyl cellulose or hectorite.

9. The essence milk according to claim 5, characterized in that: The preservative is selected from one or more of phenoxyethanol, ethylhexylglycerin, phenoxyethanol, sodium benzoate, pentylene glycol or hexylene glycol; The skin conditioning agent includes allantoin; The moisturizing agent includes sodium hyaluronate; The aromatic agent includes essence.

10. A method for preparing the essence milk according to any one of claims 5 to 9, characterized in that: The following steps are involved: 1) Disperse the thickener completely in deionized water to obtain a mixed solution, continue to add the moisturizer, stir evenly and set aside; 2) adding emollient, filler and emulsifier to the mixed solution in step 1), heating to 80-85° C., and homogenizing at 2000-3500 r / min for 3-5 minutes to completely emulsify the mixture; 3) Cooling to 43-45° C. Adding preservatives, skin conditioners, a composition with skin whitening and skin rejuvenation effects, and fragrances to the mixed solution obtained in step 2) to obtain an essence lotion with a composition with skin whitening and skin rejuvenation effects.

Images