Soothing and repairing composition and application thereof

Abstract

The invention relates to a soothing and repairing composition and application thereof. The soothing and repairing composition is prepared from saccharomycetes / rice fermentation product filtrate, mussel mucin and serum albumin. The yeast / rice fermentation product filtrate can promote endogenous repair of skin barriers by cells and effectively promote permeation and absorption of active components; the mussel mucin is also called anti-inflammatory repair peptide, and is obvious in short-term effect and high in safety; the serum albumin has good biocompatibility with a human body, so that adverse reactions possibly existing in a traditional soothing product are avoided. Compared with the prior art, the soothing and repairing composition provided by the invention plays a synergistic role aiming at the sensitive skin problem according to different mechanisms of all the components, so that the composition has the effects of easy permeation, soothing and repairing, is safe and effective for a short time, improves the untoward effects of dryness, itching, pain, stabbing and the like of the skin, and enables the skin to quickly recover to a healthy state.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemicals, and in particular to a soothing and repairing composition and its application. Background Art

[0002] Sensitive skin is a market pain point and a global problem. In recent years, with the increase in the number of people with sensitive skin due to internal and external factors such as endocrine disorders, the public's attention to sensitive skin has also increased. Sensitive skin refers specifically to a high-reaction state that occurs under physiological or pathological conditions, mainly occurring on the face, and manifested as symptoms such as burning, stinging, itching, and tightness when stimulated by physical, chemical, mental and other factors, with or without objective signs such as erythema, scaling, and capillary dilation.

[0003] At present, a variety of soothing and repairing products have emerged on the market, ranging from traditional herbal formulas to high-tech bioengineering products, and also some products containing advanced repair ingredients such as peptides, growth factors and antioxidants. These products have shortcomings such as poor penetration, good short-term effects, low safety and user dependence on the products. Therefore, it is necessary to develop soothing and repairing products that can repair the skin barrier from the endogenous source, have good penetration, good short-term effects, high safety and no dependence. Summary of the invention

[0004] In view of the problems of poor penetration effect and low safety of soothing and repairing products in the prior art, the present invention provides a soothing and moisturizing composition and application thereof.

[0005] The soothing and moisturizing composition provided by the present invention has obvious soothing and repairing effects on the skin. While solving the problem of skin sensitivity, it can achieve effective penetration of active ingredients and repair the skin barrier from the endogenous source. At the same time, it is safer and does not have the problem of dependence.

[0006] The purpose of the present invention can be achieved by the following technical solutions:

[0007] The present invention first provides a soothing and repairing composition, which comprises yeast / rice fermentation product filtrate, mussel mucin and serum albumin.

[0008] In one embodiment of the present invention, the soothing and repairing composition comprises yeast / rice fermentation product filtrate, mussel mucin and serum albumin in a mass ratio of (0.1-50):(0.1-1.5):(0.01-0.5).

[0009] In one embodiment of the present invention, the soothing and repairing composition comprises yeast / rice fermentation product filtrate, mussel mucin and serum albumin in a mass ratio of (0.5-40):(0.2-1):(0.03-0.5).

[0010] The present invention further provides application of the soothing and repairing composition in preparing facial skin care products.

[0011] In one embodiment of the present invention, the facial skin care product includes at least one of lotion, essence, emulsion, cream, facial mask and repairing cream.

[0012] In one embodiment of the present invention, the facial skin care product includes, in addition to the soothing repair composition, one or more of a solvent, an emulsifier, an emollient, a thickener, a pH adjuster, a polyol, a chelating agent or a preservative.

[0013] The present invention further provides a facial skin care product, which is a soothing and repairing cream, comprising the following components in percentage by weight:

[0014]

[0015] In one embodiment of the present invention, the facial skin care product comprises the following components in percentage by weight:

[0016]

[0017]

[0018] In one embodiment of the present invention, the facial skin care product is a repairing cream, comprising the following components in percentage by weight:

[0019]

[0020] In one embodiment of the present invention, the facial skin care product is a repairing cream, comprising the following components in percentage by weight:

[0021]

[0022]

[0023] In one embodiment of the present invention, the polyol is at least one of glycerol, butylene glycol, dipropylene glycol, 1,2-pentanediol, and sorbitol;

[0024] The chelating agent is at least one of disodium EDTA, tetrasodium EDTA, and sodium phytate;

[0025] The pH regulator is at least one of tromethamine, sodium hydroxide, potassium hydroxide, arginine, and triethanolamine;

[0026] The preservative is a mixture of 1,2-hexanediol and p-hydroxyacetophenone;

[0027] The emulsifier is at least one of cetearyl olivate, sorbitan olivate, C14-22 alcohol, C12-20 alkyl glucoside, hydrogenated lecithin, glyceryl stearate, steareth-21, steareth-2, PEG-100 stearate, polyglyceryl-3 methyl glucose distearate, and cetyl alcohol;

[0028] The thickener is at least one of xanthan gum, carbomer, acrylic acid (ester) / C10 30 alkyl acrylate cross-linked polymer, sodium polyacrylate, hectorite, ammonium acryloyldimethyltaurate / beheneth-25 methacrylate cross-linked polymer;

[0029] The emollient is at least one of squalane, caprylic / capric triglyceride, hydrogenated polydecene, ethylhexyl palmitate, coconut oil-caprylate / caprate, jojoba seed oil, meadowfoam seed oil, avocado butter, neopentyl glycol diheptanoate, and isononyl isononanoate;

[0030] The solvent is deionized water.

[0031] The present invention further provides a method for preparing the repairing facial cream, comprising the following steps:

[0032] S1: Emulsification pot: add the solvent into the emulsification pot, add the chelating agent, yeast / rice fermentation product filtrate, thickener and polyol in sequence under stirring, raise the temperature to 80-85°C, and stir at a constant temperature for 20 minutes until all the ingredients are dissolved;

[0033] S2: Oil pan: add emulsifier and emollient into the emulsifier in sequence, stir and heat to 80-85°C until all ingredients are completely dissolved;

[0034] S3: Under the condition of constant temperature and stirring at 80-85℃, slowly pump the ingredients in the oil pan into the emulsifying pot. After they are evenly mixed, homogenize at high speed at 2000-2500rpm for 5 minutes, and then start the cooling circulating water to stir and cool down;

[0035] S4: Add pH regulator and continue stirring to cool down;

[0036] S5: When the system temperature drops to 45°C, add the pre-dissolved preservatives, mussel mucin and serum albumin;

[0037] S6: When the system temperature drops to 36-40° C. (eg, 38° C.), the process ends to obtain the repairing facial cream.

[0038] In the present invention, the yeast / rice fermentation product filtrate can be made by yourself or purchased from commercial sources, and is disclosed in patents CN117257683A, CN116035959A, CN116370388B, etc. The yeast / rice fermentation product filtrate contains Alpha-KG, which can promote the proliferation of skin keratinocytes, affect the expression level of genes and proteins at the cellular level, promote the endogenous repair process of cells, and thus repair the skin barrier. On the other hand, the yeast / rice fermentation product filtrate contains active ingredients including amino acids, sugars, fruit acids, polyamines, nucleic acids, etc., which can promote the penetration of active ingredients and improve absorption capacity. In the present invention, the amount of yeast / rice fermentation product filtrate added to facial skin care products is 0.1%-50%, preferably 0.5%-40%, by mass percentage.

[0039] In the present invention, mussel mucin is a known raw material and can be purchased from commercial sources. Mussel mucin is the only known protein with a high content of dopa group (DOPA), which can inhibit inflammation and itching pain. Its unique lysine helps to form microscopic nano-scaffolds, quickly repair body tissues from the root of cells, and enhance the body's self-healing ability. In the present invention, the amount of mussel mucin added to facial skin care products is 0.1%-1.5%, preferably 0.2-1.0%, by mass percentage.

[0040] In the present invention, serum albumin is a known raw material and can be purchased from commercial sources. Serum albumin can reduce inflammation and repair the body's excessive inflammatory immune response to infection through a broad-spectrum antigen binding effect, bind and transfer inflammatory substances and inflammatory mediators, and relieve immunosuppression by reducing apoptosis of immune cells and relieving FCγ receptor blockade. In the present invention, the added amount of serum albumin is 0.01%-0.5% by mass, preferably 0.03%-0.5%.

[0041] Compared with the prior art, the present invention has the following advantages and beneficial effects:

[0042] The soothing and repairing composition provided by the present invention is prepared by compounding yeast / rice fermentation product filtrate, mussel mucin and serum albumin. The yeast / rice fermentation product filtrate can promote the endogenous repair of the skin barrier by cells, and effectively promote the penetration and absorption of active ingredients; mussel mucin is also known as anti-inflammatory repair peptide, which has obvious short-term effect and high safety; serum albumin has good biocompatibility with the human body, avoiding the adverse reactions that may exist in traditional soothing products.

[0043] The soothing and repairing composition provided by the present invention exerts a synergistic effect on sensitive skin problems based on the different mechanisms of each component, so that the composition has both easy penetration and soothing and repairing effects, is safe and effective in the short term, improves adverse reactions such as dryness, itching, pain, and tingling of the skin, and allows the skin to quickly return to a healthy state. DETAILED DESCRIPTION

[0044] The technical solution of the present invention is further described below by specific embodiments, which do not limit the protection scope of the present invention. Some non-essential modifications and adjustments made by others based on the concept of the present invention still fall within the protection scope of the present invention.

[0045] The raw materials not specially described in the following examples are all known raw materials from commercial channels.

[0046] Examples 1-6

[0047] Examples 1-6 provide soothing and repairing facial creams with different ingredients, and the specific formulas are shown in Table 1.

[0048] Table 1 Raw material weight percentage composition of Examples 1-6 (wt%)

[0049]

[0050]

[0051] The soothing and repairing facial creams of different ingredients in Examples 1-6 are prepared according to the mass percentage of each component in Table 1, and the preparation method comprises the following steps:

[0052] S1: Emulsification pot: add deionized water into the emulsification pot, add the chelating agent, yeast / rice fermentation product filtrate, thickener and polyol in sequence under stirring, raise the temperature to 80-85°C, and stir at a constant temperature for 20 minutes until all the ingredients are dissolved;

[0053] S2: Oil pan: add emulsifier and emollient into the emulsifier in sequence, stir and heat to 80-85°C until all ingredients are completely dissolved;

[0054] S3: Under the condition of constant temperature and stirring at 80-85℃, slowly pump the ingredients in the oil pan into the emulsifying pot. After they are evenly mixed, homogenize at high speed at 2000-2500rpm for 5 minutes, and then start the cooling circulating water to stir and cool down;

[0055] S4: Add pH regulator and continue stirring to cool down;

[0056] S5: When the system temperature drops to 45°C, add the pre-dissolved preservatives, mussel mucin and serum albumin;

[0057] S6: When the system temperature drops to about 38° C., the machine is stopped and the material is discharged for sampling, thereby obtaining soothing and repairing facial creams with different ingredients of Examples 1-6.

[0058] Comparative Examples 1-7

[0059] Comparative Examples 1-7 provide facial creams with different ingredients, and the specific formulas are shown in Table 2.

[0060] Table 2 Comparative Examples 1-7 Raw Materials Weight Percent Composition (wt%)

[0061]

[0062]

[0063]

[0064] The facial creams of Comparative Examples 1-7 are prepared according to the mass percentage of each component in Table 2 and the preparation methods are referred to Examples 1-6.

[0065] The soothing and repairing creams prepared in the above different embodiments and comparative examples were tested for performance

[0066] (1) With reference to SN / T 2329-2009 “Cosmetic eye irritation / chicken chorioallantoic membrane test”, the test substances (the creams of the examples and comparative examples) were subjected to an eye irritation test, i.e., a safety test.

[0067] Experimental method: Fertilized chicken embryos less than 7 days old were used and incubated in an incubator at 37.6±0.5℃ and 50%-70% humidity for 9 days.

[0068] Preparation of CAM: Check the eggs, mark the position of the air chamber on the surface of the eggshell, peel off the marked eggshell part with tweezers to expose the white egg membrane, and be careful not to damage the integrity of the egg membrane. Add 0.5mL of 0.9% NaCl solution to fully moisten the egg membrane, gently absorb the surface liquid with a paper towel, and carefully remove the inner membrane with tweezers to ensure that the vascular membrane is not damaged. Take 0.3ml of the transparent test substance (the cream of the embodiment and the comparative example) and directly add it to the surface of the CAM, observe the reaction of the CAM, and record the time of occurrence of each toxic effect within 5 minutes of action. Reaction endpoint method: Take 0.3mL of the non-transparent test substance and evenly add or smear it on the surface of the CAM. After 3 minutes of action, use 0.9% NaCl solution to wash off the test substance and observe the degree of change of each toxic effect of the CAM.

[0069] Irritation score (IS): A test using the reaction time method, using the formula

[0070] Irritation score (IS), the result is rounded to two decimal places. According to the calculated IS value, classify the eye irritation of the test substance according to Table 2.

[0071] Irritation score IS = (301-SecH)*5 / 300+(301-SecL)*7 / 300+(301-SecC)*9 / 300

[0072] Where: sec H (hemorrhage time) is the average time when bleeding begins to occur on the CAM membrane, in seconds (s);

[0073] sec L (vessel lysis time) - the average time at which vascular lysis is observed on the CAM membrane, in seconds (s);

[0074] sec C (coagulation time) - the average time for the onset of coagulation observed on the CAM membrane, in seconds (s).

[0075] The criteria for judging the reaction time results are shown in Table 3.

[0076] Table 3 Reaction time result judgment criteria

[0077]

[0078] End point score method (ES): For tests conducted using the reaction endpoint method, the endpoint score (ES) should be calculated, and the result should be rounded to two decimal places. The score for each chicken embryo = the sum of the bleeding, coagulation and vascular melting observed for each chicken embryo, ES = the mathematical sum of the scores of 6 chicken embryos. Classify the eye irritation of the test substance according to Table 4 based on the ES value.

[0079] Table 4 Criteria for determining the results of the reaction endpoint method

[0080] Stimulus score ES≤12 12<ES<16 ES≥16 Irritant phenols No / mild irritation Moderate irritation Strong irritant / corrosive

[0081] The test results are shown in Table 5, and it can be seen that Examples 1-6 and Comparative Examples 1-7 are non-irritating.

[0082] Table 5 Statistics of irritation test results

[0083]

[0084] (2) To verify the effect of the soothing and repairing composition of the present invention, the anti-allergic and soothing effect test was conducted on the creams obtained in Examples 1-6 and Comparative Examples 1-7 to verify their effects on various sensitive skin symptoms:

[0085] Test method: 130 subjects were invited, healthy Chinese subjects with sensitive skin (screened by lactic acid stinging assessment), aged 24-45 years old, all with different degrees of sensitivity problems, and met the voluntary inclusion and exclusion criteria of the subjects, and were randomly divided into 13 groups, 10 people in each group, and each group used the same test sample. The 13 groups of subjects applied the creams of Examples 1-6 and Comparative Examples 1-7 on the left face skin, respectively, which were called the test group;

[0086] Test method: All volunteers applied the test samples (the creams obtained in Examples 1-6 and Comparative Examples 1-7) to the entire face at a dosage of 1±0.05 g / time according to the corresponding groups, once in the morning and evening every day, for 14 consecutive days, during which no other skin care products or similar functional products were used; after use, the efficacy of the product was evaluated using a scoring system, based on the improvement of various symptoms (including redness, burning sensation, tingling sensation, itching, and dryness, and no score was given if there was no such symptom), with a full score of 5 points. The higher the score, the better the symptom relief and repair effect. After removing the highest and lowest scores in each group, the average score was calculated, and the average score of each symptom score was then calculated to statistically calculate the comprehensive effect of the test sample.

[0087] The test results are shown in Table 6.

[0088] Table 6 Effect of using the facial cream of the embodiment and comparative example

[0089]

[0090]

[0091] As can be seen from Table 6, the soothing and repairing composition of the present invention has a very excellent anti-allergic and soothing effect, and can effectively relieve and inhibit the redness, swelling, burning sensation, tingling sensation, itching and dryness of sensitive skin. Examples 1-6 are far superior to the products obtained in Comparative Examples 1 to 7; among them, the soothing and repairing composition obtained in Example 6 has the highest comprehensive evaluation.

[0092] (3) Skin moisturizing and hydration

[0093] In addition to the anti-allergic and soothing effects, the products obtained in the examples and comparative examples were also tested for their moisturizing properties after direct use.

[0094] Test method: The facial skin moisture content of the test subjects before and after using the example or comparative example cream in test (2) was measured. The facial skin moisture content was measured using a transepidermal water loss meter Vapometer (model SWL5201, Delfin, Finland). The test used the TEWL parameter to compare the facial skin moisture loss before and after the product was used.

[0095] Where △TEWL=(TEWL1-TEWL2) / TEWL1×100%,

[0096] TEWL1 is the test value before using the product, and TEWL2 is the test value after using the product. The larger the △TEWL value, the greater the reduction in transepidermal water loss of the test skin after using the product, and the better the barrier repair and moisturizing effects of the product.

[0097] The average values ​​of each group were recorded and calculated, and the results are shown in Table 7.

[0098] Table 7 Transepidermal water loss change value

[0099]

[0100]

[0101] It can be seen from Table 7 that the soothing and repairing compositions obtained in Examples 1 to 6 not only have the anti-allergic and soothing repair effects, but can also significantly improve the moisturizing effect of the skin and repair the skin's water barrier. The transepidermal moisture retention rate of each product reached more than 28%; in contrast, the moisturizing effects of the products obtained in Comparative Examples 1 to 7 are also significantly inferior to those of Examples 1-6.

[0102] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the scope of protection of the present invention.

Claims

1. A soothing and repairing composition, characterized in that: The soothing and repairing composition comprises yeast / rice fermentation product filtrate, mussel mucin and serum albumin in a mass ratio of (0.1-50):(0.1-1.5):(0.01-0.5).

2. A soothing and repairing composition according to claim 1, characterized in that: The soothing and repairing composition comprises yeast / rice fermentation product filtrate, mussel mucin and serum albumin in a mass ratio of (0.5-40):(0.2-1):(0.03-0.5).

3. Use of the soothing and repairing composition according to claim 1 or 2 in the preparation of facial skin care products.

4. The use according to claim 3, characterized in that: The facial skin care products include at least one of lotion, essence, emulsion, cream, mask and repair cream; The facial skin care product includes, in addition to the soothing repair composition, one or more of a solvent, an emulsifier, a moisturizer, a thickener, a pH regulator, a polyol, a chelating agent or a preservative.

5. A repairing facial cream, characterized in that: Contains the following components in weight percentage:

6. A repairing facial cream according to claim 5, characterized in that: Contains the following components in weight percentage:

7. A repairing facial cream according to claim 5, characterized in that: Contains the following components in weight percentage:

8. A repairing facial cream according to claim 7, characterized in that: The repairing facial cream comprises the following components in percentage by weight:

9. A repairing facial cream according to any one of claims 5 to 8, characterized in that: The polyol is at least one of glycerol, butylene glycol, dipropylene glycol, 1,2-pentanediol, and sorbitol; The chelating agent is at least one of disodium EDTA, tetrasodium EDTA, and sodium phytate; The pH regulator is at least one of tromethamine, sodium hydroxide, potassium hydroxide, arginine, and triethanolamine; The preservative is a mixture of 1,2-hexanediol and p-hydroxyacetophenone; The emulsifier is at least one of cetearyl olivate, sorbitan olivate, C14-22 alcohol, C12-20 alkyl glucoside, hydrogenated lecithin, glyceryl stearate, steareth-21, steareth-2, PEG-100 stearate, polyglyceryl-3 methyl glucose distearate, and cetyl alcohol; The thickener is at least one of xanthan gum, carbomer, acrylic acid (ester) / C10 30 alkyl acrylate cross-linked polymer, sodium polyacrylate, hectorite, ammonium acryloyldimethyltaurate / beheneth-25 methacrylate cross-linked polymer; The emollient is at least one of squalane, caprylic / capric triglyceride, hydrogenated polydecene, ethylhexyl palmitate, coconut oil-caprylate / caprate, jojoba seed oil, meadowfoam seed oil, avocado butter, neopentyl glycol diheptanoate, and isononyl isononanoate; The solvent is deionized water.

10. The method for preparing the repairing facial cream according to any one of claims 5 to 8, characterized in that: The following steps are involved: S1: Emulsification pot: add the solvent into the emulsification pot, add the chelating agent, yeast / rice fermentation product filtrate, thickener and polyol in sequence under stirring, raise the temperature to 80-85°C, and stir at a constant temperature for 20 minutes until all the ingredients are dissolved; S2: Oil pan: add emulsifier and emollient into the emulsifier in sequence, stir and heat to 80-85°C until all ingredients are completely dissolved; S3: Under the condition of constant temperature and stirring at 80-85℃, slowly pump the ingredients in the oil pan into the emulsifying pot. After they are evenly mixed, homogenize at high speed at 2000-2500rpm for 5 minutes, and then start the cooling circulating water to stir and cool down; S4: Add pH regulator and continue stirring to cool down; S5: When the system temperature drops to 45°C, add the pre-dissolved preservatives, mussel mucin and serum albumin; S6: When the system temperature drops to 36-40° C., the process ends to obtain the repairing facial cream.

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