Acetylcysteine preparation and energy-saving jet mill for producing acetylcysteine preparation

Abstract

The invention discloses an acetylcysteine preparation, which comprises 0.1-0.5 g of acetylcysteine in each part, 0.4-0.8 g of lactose and pregelatinized starch mixed according to a ratio of 1: 1-3: 1 in each part, 0.03-0.1 g of sodium carboxymethyl starch in each part, povidone accounting for 8-15% of the weight of acetylcysteine, and the balance of water. The composite flavoring agent is prepared by mixing natural fruit juice concentrate and stevioside according to a ratio of 4: 1-5: 1, the total dosage of each part is 0.02 g-0. 04g, and the dosage of magnesium stearate is 0.005 g-0. 02g; the invention further discloses an energy-saving jet mill for producing the acetylcysteine preparation, the energy-saving jet mill comprises a crushing cavity, the crushing cavity comprises an upper machine cavity and a lower machine cavity, a feeding pipe and a discharging pipe are obliquely arranged on the upper machine cavity, and the lower machine cavity is communicated with an air feeding pipe and an air inlet pipe. The device has the advantages that efficient crushing and fine granularity control are realized, and the product quality is guaranteed; the air flow is flexibly regulated and controlled, the material characteristics are adapted, the efficiency is improved, the cost is reduced, sealing is reliable, flow guiding is intelligent, and stable and accurate production is ensured.

Description

Technical Field

[0001] The invention relates to the technical field of drug production, in particular to an acetylcysteine ​​preparation and an energy-saving airflow pulverizer for producing the same. Background Art

[0002] In the pharmaceutical field, acetylcysteine, as a key expectorant, is widely used to treat various respiratory diseases, such as chronic bronchitis, emphysema, and breathing difficulties caused by thick sputum. With the continuous growth of medical needs, more and more stringent requirements are placed on the quality, production efficiency and cost control of acetylcysteine ​​preparations.

[0003] The traditional method of preparing acetylcysteine ​​preparations mostly uses conventional mechanical crushing methods in the raw material crushing process, such as ball mills, hammer mills, etc. However, these traditional equipment have many disadvantages. On the one hand, it is difficult to accurately control the particle size of the material during the crushing process, which often leads to uneven particle size distribution. The finished product contains both large particles that affect the dissolution and absorption of the drug, and too much fine powder, resulting in material waste. It cannot meet the strict standards of modern preparations for the consistency of raw material particle size, which in turn affects the stability of the drug's efficacy.

[0004] In addition, in the previous acetylcysteine ​​preparation production equipment, the design of the guide plate has significant defects. Most traditional devices are either not equipped with a guide plate, and the material is in a disordered flow state driven by the airflow in the crushing chamber, which makes it easy for coarse particles to accumulate locally and cannot fully participate in crushing, reducing the utilization rate of raw materials and extending the production cycle. Even if some equipment is equipped with a guide plate, its structure is extremely simple and fixed, and cannot be flexibly adjusted according to real-time working conditions. For example, when processing acetylcysteine ​​raw materials of different hardness or viscosity, the fixed guide plate cannot optimize the airflow direction to adapt to the changes in the material, resulting in uneven fluidization of the material and greatly reduced crushing effect.

[0005] Therefore, we propose an acetylcysteine ​​preparation and an energy-saving airflow pulverizer for its production to solve the above problems. Summary of the invention

[0006] The purpose of the present invention is to solve the problems in the prior art and to provide an acetylcysteine ​​preparation and an energy-saving airflow pulverizer for its production.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions: An acetylcysteine ​​preparation, the prescription composition of which comprises: Acetylcysteine, 0.1g-0.5g per serving; Lactose and pregelatinized starch are mixed in a ratio of 1:1-3:1, and the total amount per serving is 0.4g-0.8g; Sodium carboxymethyl starch, dosage per serving is 0.03g-0.1g; Povidone, the dosage is 8%-15% of the weight of acetylcysteine; A composite flavoring agent in which natural fruit juice concentrate and steviol glycoside are mixed in a ratio of 4:1-5:1, with a total dosage of 0.02g-0.04g per serving; Magnesium stearate, dosage per serving 0.005g-0.02g.

[0008] An energy-saving air flow pulverizer for producing acetylcysteine ​​preparations comprises a pulverizing chamber, wherein the pulverizing chamber comprises an upper chamber and a lower chamber, wherein a feed pipe and a discharge pipe are obliquely arranged on the upper chamber, and the center line of the discharge pipe coincides with the center line of the upper chamber, wherein an air supply pipe and an air inlet pipe are connected to the lower chamber, and the center line of the air inlet pipe coincides with the center line of the lower chamber, wherein a lower working cylinder is arranged in the lower chamber, an upper working cylinder is arranged on the inner top wall of the upper chamber, an annular pulverizing cylinder is commonly clamped between the upper working cylinder and the lower working cylinder, a plurality of feed holes are symmetrically provided on the upper surface of the upper working cylinder, and the feed pipe is connected with one of the feed holes, a plurality of nozzles are evenly provided on the outer side wall of the annular pulverizing cylinder, a lower extension pipe is arranged in the middle of the lower working cylinder, and the lower extension pipe is connected with the air inlet pipe, an upper extension pipe is extended in the middle of the upper working cylinder, and the upper extension pipe is connected with the discharge pipe, and the lower extension pipe is connected with the upper extension pipe.

[0009] In the above energy-saving airflow pulverizer for producing acetylcysteine ​​preparations, the air supply pipe is located between the lower machine chamber and the annular pulverizing cylinder.

[0010] In the above-mentioned energy-saving air flow mill for producing acetylcysteine ​​preparations, two sealing rings are symmetrically clamped on the outer side walls of the upper machine cavity and the lower machine cavity, and the connection between the upper machine cavity and the lower machine cavity is located between the two sealing rings. The end faces of the upper machine cavity and the lower machine cavity are both provided with sealing ring grooves, and a sealing ring is clamped between the two sealing ring grooves.

[0011] In the above-mentioned energy-saving air flow mill for the production of acetylcysteine ​​preparations, a plurality of support seats are symmetrically installed on the inner side wall of the lower machine cavity, a guide plate is installed on each of the support seats through a rotating shaft, and the guide plates are located in the upper machine cavity and the lower machine cavity, and the upper end of each rotating shaft passes through the upper machine cavity and is provided with a steering assembly.

[0012] In the above-mentioned energy-saving air flow mill for producing acetylcysteine ​​preparations, the steering assembly includes an annular protective cover, an incomplete gear ring is installed in the annular protective cover, the upper end of each of the rotating shafts extends into the annular protective cover and is installed with a steering gear, and each steering gear is meshed with the incomplete gear ring, an energy-saving motor is installed on the upper end surface of the annular protective cover, the output end of the energy-saving motor extends into the annular protective cover and is installed with a driving gear, and the driving gear is meshed with the incomplete gear ring.

[0013] A method for preparing an acetylcysteine ​​preparation comprises the following steps: S1. The acetylcysteine ​​raw material is initially crushed and passed through a 60-80 mesh sieve. Lactose, pregelatinized starch, sodium carboxymethyl starch, povidone, natural fruit juice concentrate, steviol glycosides, and magnesium stearate are respectively passed through a 80-100 mesh sieve for later use; S2, using a jet mill to crush the pretreated acetylcysteine, adjusting the air flow pressure to 0.6-1.0MPa, the feed rate to 10-20g / min, and the crushing time to 10-20min; S3. Accurately weigh the crushed acetylcysteine, lactose, and pregelatinized starch according to the prescription amount, place them in a high-speed stirring granulator, add an appropriate amount of polyvidone aqueous solution (concentration 5%-10%), stir at a speed of 400-600 rpm to form a soft material, and granulate the soft material through a 10-14 mesh sieve; S4, placing the obtained wet granules into a vacuum drying oven, and drying at 45-55°C until the moisture content is less than 2.5%; S5. The dried granules are sieved through a 14-18 mesh sieve, and then sodium carboxymethyl starch, natural fruit juice concentrate, stevioside, and magnesium stearate are added, placed in a three-dimensional mixer, and mixed at a speed of 10-15 rpm for 8-12 minutes. Compared with the prior art, the present invention has the following beneficial effects: 1. The airflow crushing design allows the acetylcysteine ​​raw material to be fully fluidized and collided in the annular crushing barrel. The precise docking of the air inlet pipe with the lower machine cavity and the lower extension pipe ensures that the high-pressure airflow rushes in straightly, providing strong power for crushing. The nozzle on the outer wall of the annular crushing barrel introduces additional airflow to optimize the airflow field, making the material crushing more efficient, and can accurately reach the ideal particle size range, meet the strict requirements of the preparation for the particle size of the raw materials, and improve the stability of product quality. Based on the natural grading phenomenon of the airflow velocity gradient, qualified fine powder and coarse particles are automatically separated during the crushing process. The fine powder can be quickly transferred through the upper extension tube and the discharge pipe to avoid excessive crushing, which saves energy and ensures the characteristics of the material, providing a high-quality raw material foundation for subsequent granulation.

[0014] 2. The air delivery pipe is located between the key lower chamber and the annular crushing cylinder. Combined with the second booster valve, the airflow direction, flow rate and pressure can be adjusted in real time according to the characteristics of different batches of acetylcysteine ​​raw materials (such as hardness and viscosity) and the requirements of each stage of crushing. Whether it is the initial crushing or the later fine crushing, it can create an adaptive airflow environment to ensure consistent crushing effect and improve the equipment's adaptability to material diversity.

[0015] 3. The guide plate can flexibly adjust its angle according to the working conditions during the operation of the equipment. On the one hand, it can rectify and disperse the high-speed airflow flowing into the air intake pipe, so that the airflow in the annular crushing tube is evenly distributed, avoiding local energy waste and excessive impact, and improving the crushing efficiency; on the other hand, it can guide the substandard coarse particles back to the crushing area, reduce the amount of material discharge and reprocessing, realize material recycling, save energy and improve the utilization rate of raw materials. The precise guide effect maintains a stable flow field in the crushing chamber, reduces the energy loss caused by air flow turbulence, makes the equipment more energy-efficient, and significantly reduces the long-term operating cost.

[0016] In summary, the present invention realizes efficient crushing and fine particle size control to ensure product quality; flexibly regulates airflow, adapts to material characteristics, improves efficiency, reduces costs, has reliable sealing and intelligent flow guidance, and ensures stable and accurate production. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of the structure of an energy-saving airflow pulverizer for producing an acetylcysteine ​​preparation proposed by the present invention; Figure 2 A schematic diagram of the structure of a grinding chamber in an energy-saving airflow mill for producing acetylcysteine ​​preparations proposed by the present invention; Figure 3 for Figure 2 Another visual perspective; Figure 4 This is a visual diagram of the cutaway state of the pulverizing chamber in an energy-saving airflow pulverizer for producing acetylcysteine ​​preparations proposed by the present invention; Figure 5 A schematic diagram of the internal structure of a grinding chamber in an energy-saving airflow mill for producing acetylcysteine ​​preparations proposed by the present invention; Figure 6 This is a schematic diagram of the structure of the annular grinding cylinder in an energy-saving airflow pulverizer for producing acetylcysteine ​​preparations proposed by the present invention; Figure 7 This is an enlarged view of the structure of the guide plate part of an energy-saving air flow pulverizer for producing acetylcysteine ​​preparations proposed by the present invention.

[0018] In the figure: 1 feeder, 2 compressed air storage tank, 3 boost valve 2, 4 boost valve 1, 5 feed hopper, 6 upper machine cavity, 7 gas powder separator, 8 blower, 9 discharge pipe, 10 feed pipe, 11 energy-saving motor, 12 sealing ring, 13 air intake pipe, 14 annular protective cover, 15 lower machine cavity, 16 air delivery pipe, 17 incomplete gear ring, 18 steering gear, 19 annular crushing cylinder, 20 support seat, 21 guide plate, 22 nozzle, 23 lower working cylinder, 24 lower extension pipe, 25 upper working cylinder, 26 upper extension pipe, 27 feed hole, 28 driving gear, 29 sealing ring. DETAILED DESCRIPTION

[0019] The following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.

[0020] Example An acetylcysteine ​​preparation, the prescription composition of which comprises: Acetylcysteine, 0.1g-0.5g per serving; Lactose and pregelatinized starch are mixed in a ratio of 1:1-3:1, and the total amount per serving is 0.4g-0.8g; Sodium carboxymethyl starch, dosage per serving is 0.03g-0.1g; Povidone, the dosage is 8%-15% of the weight of acetylcysteine; A composite flavoring agent in which natural fruit juice concentrate and steviol glycoside are mixed in a ratio of 4:1-5:1, with a total dosage of 0.02g-0.04g per serving; Magnesium stearate, dosage per serving 0.005g-0.02g.

[0021] A method for preparing an acetylcysteine ​​preparation comprises the following steps: S1. The acetylcysteine ​​raw material is initially crushed and passed through a 60-80 mesh sieve. Lactose, pregelatinized starch, sodium carboxymethyl starch, povidone, natural fruit juice concentrate, steviol glycosides, and magnesium stearate are respectively passed through a 80-100 mesh sieve for later use; S2, using a jet mill to crush the pretreated acetylcysteine, adjusting the air flow pressure to 0.6-1.0MPa, the feed rate to 10-20g / min, and the crushing time to 10-20min; S3. Accurately weigh the crushed acetylcysteine, lactose, and pregelatinized starch according to the prescription amount, place them in a high-speed stirring granulator, add an appropriate amount of polyvidone aqueous solution (concentration 5%-10%), stir at a speed of 400-600 rpm to form a soft material, and granulate the soft material through a 10-14 mesh sieve; S4, placing the obtained wet granules into a vacuum drying oven, and drying at 45-55°C until the moisture content is less than 2.5%; S5. The dried granules are sieved through a 14-18 mesh sieve, and then sodium carboxymethyl starch, natural fruit juice concentrate, steviol glycosides, and magnesium stearate are added, placed in a three-dimensional mixer, and mixed at a speed of 10-15 rpm for 8-12 minutes.

[0022] refer to Figure 1-7 , an energy-saving airflow pulverizer for producing acetylcysteine ​​preparations, including a pulverizing chamber, the pulverizing chamber including an upper machine chamber 6 and a lower machine chamber 15, a feed pipe 10 and a discharge pipe 9 are obliquely arranged on the upper machine chamber 6, and the center line of the discharge pipe 9 coincides with the center line of the upper machine chamber 6, the feed pipe 10 is connected to a feed hopper 5, the pipe part connecting the feed pipe 10 and the feed hopper 5 is connected and a booster valve 4 is installed, the input end of the feed hopper 5 is connected to a feeder 1, the discharge pipe 9 is connected to an air-powder separator 7, the air-powder separator 7 is connected to a blower 8, the lower machine chamber 15 is connected to an air delivery pipe 16 and an air inlet pipe 13, and the center line of the air inlet pipe 13 coincides with the center line of the lower machine chamber 15, the air inlet pipe 13 is connected to a compressed air storage tank 2, and the air delivery pipe 16 is connected to the air inlet pipe 13. The air pipe 16 is connected to the boost valve 23, a lower working cylinder 23 is provided in the lower machine cavity 15, an upper working cylinder 25 is provided on the inner top wall of the upper machine cavity 6, an annular crushing cylinder 19 is commonly clamped between the upper working cylinder 25 and the lower working cylinder 23, a plurality of feed holes 27 are symmetrically provided on the upper surface of the upper working cylinder 25, and the feed pipe 10 is connected to one of the feed holes 27, a plurality of nozzles 22 are evenly provided on the outer side wall of the annular crushing cylinder 19, a lower extension pipe 24 is provided in the middle part of the lower working cylinder 23, and the lower extension pipe 24 is connected to the air inlet pipe 13, an upper extension pipe 26 is extended from the middle part of the upper working cylinder 25, and the upper extension pipe 26 is connected to the discharge pipe 9, and the lower extension pipe 24 is connected to the upper extension pipe 26.

[0023] The air supply pipe 16 is located between the lower machine chamber 15 and the annular crushing cylinder 19 .

[0024] Two sealing rings 12 are symmetrically provided on the outer side walls of the upper machine cavity 6 and the lower machine cavity 15, and the connection between the upper machine cavity 6 and the lower machine cavity 15 is located between the two sealing rings 12. The end faces of the upper machine cavity 6 and the lower machine cavity 15 are both provided with sealing ring grooves, and a sealing ring 29 is commonly provided between the two sealing ring grooves.

[0025] A plurality of support seats 20 are symmetrically installed on the inner wall of the lower machine cavity 15, and a guide plate 21 is installed on each support seat 20 through a rotating shaft, and the guide plate 21 is located in the upper machine cavity 6 and the lower machine cavity 15. The upper end of each rotating shaft passes through the upper machine cavity 6 and is provided with a steering assembly.

[0026] The steering assembly includes an annular protective cover 14, in which an incomplete gear ring 17 is installed. The upper end of each rotating shaft extends into the annular protective cover 14 and is installed with a steering gear 18, and each steering gear 18 is meshed with the incomplete gear ring 17. An energy-saving motor 11 is installed on the upper end surface of the annular protective cover 14, and the output end of the energy-saving motor 11 extends into the annular protective cover 14 and is installed with a driving gear 28, and the driving gear 28 is meshed with the incomplete gear ring 17.

[0027] Material feeding: The acetylcysteine ​​raw material is transported from the feeder 1 to the feed hopper 5, which plays the role of preliminary buffering and collecting materials. In the pipeline part connecting the feed pipe 10 and the feed hopper 5, a booster valve 4 is installed to increase the pressure of the material entering the feed pipe 10, ensuring that the material can move smoothly and stably along the inclined feed pipe 10. The feed pipe 10 is connected to the feed hole 27 opened on the upper surface of the upper machine cavity 6, and the material precisely enters the upper working cylinder 25 in the upper machine cavity 6 to prepare for the subsequent crushing process.

[0028] At the same time, other auxiliary materials such as lactose, pregelatinized starch, sodium carboxymethyl starch, povidone, natural fruit juice concentrate, steviol glycoside, magnesium stearate, etc., after fine pretreatment through 80-100 mesh sieves in the early stage, are orderly involved in the preparation process in the subsequent corresponding steps according to the requirements of the process nodes.

[0029] Airflow crushing: The compressed air storage tank 2 is used as a high-pressure gas source and is closely connected to the air intake pipe 13 connected to the lower machine cavity 15. The center line of the air intake pipe 13 coincides with the center line of the lower machine cavity 15, which ensures that the high-pressure gas can rush into the lower extension pipe 24 in the middle of the lower working cylinder 23 in a straight line. A strong high-speed rising airflow is instantly formed inside the equipment. This airflow is the core driving force of the airflow circulation in the entire crushing chamber. The high-speed airflow gushing from the lower extension pipe 24 penetrates the annular crushing cylinder 19 upward, so that the acetylcysteine ​​raw material entering the annular crushing cylinder 19 is rapidly fluidized under the drag of the airflow and suspended in the airflow. At this time, the raw material particles and the raw material and the inner wall of the annular crushing cylinder 19 collide violently, achieving efficient crushing. Several nozzles 22 evenly arranged on the outer wall of the annular pulverizing cylinder 19 can introduce additional airflow, further optimize the airflow field in the pulverizing chamber, strengthen the fluidization effect of the material, and ensure that the material can be pulverized to an ideal particle size range. The air supply pipe 16 is located between the lower machine chamber 15 and the annular pulverizing cylinder 19, and is connected to the boost valve 23. It can flexibly adjust the airflow direction, flow rate and pressure distribution entering the area according to the material characteristics and the requirements of the pulverizing stage, and cooperate with the airflow introduced by the air intake pipe 13 to finely control the airflow environment in the pulverizing chamber to ensure the consistency and reliability of the pulverizing effect.

[0030] During the material crushing process, a natural grading phenomenon will occur based on the air flow velocity gradient and the material particle characteristics. The fine powder that has reached the qualified particle size moves upward under the action of the airflow, passes through the top of the annular crushing cylinder 19 and enters the upper working cylinder 25. The upper extension tube 26 extending from the middle of the upper working cylinder 25 is connected to the discharge pipe 9, and the center line of the discharge pipe 9 coincides with the center line of the upper machine cavity 6, providing a smooth discharge channel for the fine powder. Under the continuous push of the airflow, the fine powder flows into the discharge pipe 9 along the upper extension tube 26 without hindrance, and then enters the gas-powder separator 7.

[0031] The qualified material powder separated from the gas-powder separator 7 enters the high-speed stirring granulator together with other auxiliary materials (such as lactose, pregelatinized starch, etc.) weighed according to the prescription amount. Here, an appropriate amount of polyvidone aqueous solution (concentration 5%-10%) is added as a binder, and the mixture is stirred at a speed of 400-600 rpm to form a soft material, which is granulated through a 10-14 mesh sieve, and then the obtained wet granules are placed in a vacuum drying oven and dried at 45-55°C to a moisture content of less than 2.5%. The dried granules are granulated through a 14-18 mesh sieve, and then sodium carboxymethyl starch, natural fruit juice concentrate, stevioside, and magnesium stearate are added, placed in a three-dimensional mixer, and mixed at a speed of 10-15 rpm for 8-12 minutes to complete the preparation of the acetylcysteine ​​preparation.

[0032] It is worth mentioning that a plurality of support seats 20 are symmetrically installed on the inner wall of the lower machine chamber 15, and a guide plate 21 is installed on the support seat 20 through a rotating shaft, and the guide plate 21 is located in the upper machine chamber 6 and the lower machine chamber 15. During the operation of the equipment, the guide plate 21 can flexibly adjust the angle according to the fluidization and crushing requirements of the material. Its main functions include: rectifying and dispersing the high-speed airflow pouring into the lower machine chamber 15 from the air inlet pipe 13, so that it enters the annular crushing barrel 19 more evenly to avoid excessive impact of local airflow; guiding the circulation of materials in the crushing chamber, prompting heavier coarse particles that do not meet the standards to return to the high-speed airflow area in the annular crushing barrel 19 under the synergistic effect of the airflow and the guide plate 21, and be crushed again to improve the material utilization rate; an incomplete gear ring 17 is installed in the annular protective cover 14, and the energy-saving motor 11 is used as the power source. The outlet extends into the annular protective cover 14 and is equipped with a driving gear 28, which meshes with the incomplete gear ring 17. The upper end of each rotating shaft extends into the annular protective cover 14 and is equipped with a steering gear 18, and each steering gear 18 meshes with the incomplete gear ring 17. When the energy-saving motor 11 is started, the incomplete gear ring 17 is driven to rotate through the gear transmission, and then the steering gears 18 are driven to rotate, and finally the angle of the guide plate 21 is adjusted. Through the precise control of the energy-saving motor 11 by the control system, the angle of the guide plate 21 can be accurately adjusted according to the real-time working conditions in the crushing chamber, such as material accumulation, air flow velocity and pressure distribution, so as to achieve the best guide effect, provide dynamic adaptability for the crushing, fluidization and the entire preparation process of acetylcysteine ​​raw materials, and ensure stable and efficient operation of the production process.

[0033] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. An acetylcysteine ​​preparation, characterized in that: include: Acetylcysteine, 0.1g-0.5g per serving; Lactose and pregelatinized starch are mixed in a ratio of 1:1-3:1, and the total amount per serving is 0.4g-0.8g; Sodium carboxymethyl starch, dosage per serving is 0.03g-0.1g; Povidone, the dosage is 8%-15% of the weight of acetylcysteine; A compound flavoring agent in which natural fruit juice concentrate and steviol glycoside are mixed in a ratio of 4:1-5:1, with a total dosage of 0.02g-0.04g per serving; Magnesium stearate, dosage per serving 0.005g-0.02g.

2. An energy-saving airflow mill for producing acetylcysteine ​​preparations, characterized in that: The invention comprises a pulverizing chamber, wherein the pulverizing chamber comprises an upper chamber (6) and a lower chamber (15); a feed pipe (10) and a discharge pipe (9) are obliquely arranged on the upper chamber (6), and the center line of the discharge pipe (9) coincides with the center line of the upper chamber (6); an air supply pipe (16) and an air inlet pipe (13) are connected to the lower chamber (15), and the center line of the air inlet pipe (13) coincides with the center line of the lower chamber (15); a lower working cylinder (23) is arranged in the lower chamber (15); an upper working cylinder (25) is arranged on the inner top wall of the upper chamber (6), and a space between the upper working cylinder (25) and the lower working cylinder (23) is provided. The same card is provided with an annular crushing cylinder (19), the upper surface of the upper working cylinder (25) is symmetrically provided with a plurality of feed holes (27), and the feed pipe (10) is connected to one of the feed holes (27), the outer wall of the annular crushing cylinder (19) is evenly provided with a plurality of nozzles (22), the middle part of the lower working cylinder (23) is provided with a lower extension pipe (24), and the lower extension pipe (24) is connected to the air inlet pipe (13), the middle part of the upper working cylinder (25) is extended with an upper extension pipe (26), and the upper extension pipe (26) is connected to the discharge pipe (9), and the lower extension pipe (24) is connected to the upper extension pipe (26).

3. The energy-saving airflow mill for producing an acetylcysteine ​​preparation according to claim 2, characterized in that: The air supply pipe (16) is located between the lower machine chamber (15) and the annular crushing cylinder (19).

4. The energy-saving airflow mill for producing an acetylcysteine ​​preparation according to claim 2, characterized in that: Two sealing rings (12) are symmetrically arranged on the outer side walls of the upper machine cavity (6) and the lower machine cavity (15), and the connection between the upper machine cavity (6) and the lower machine cavity (15) is located between the two sealing rings (12). The end surfaces of the upper machine cavity (6) and the lower machine cavity (15) are both provided with sealing ring grooves, and a sealing ring (29) is arranged between the two sealing ring grooves.

5. The energy-saving airflow mill for producing acetylcysteine ​​preparation according to claim 2, characterized in that: A plurality of support seats (20) are symmetrically mounted on the inner side wall of the lower machine cavity (15), and a guide plate (21) is mounted on each of the support seats (20) via a rotating shaft. The guide plate (21) is located in the upper machine cavity (6) and the lower machine cavity (15), and the upper end of each rotating shaft passes through the upper machine cavity (6) and is provided with a steering assembly.

6. The energy-saving airflow mill for producing acetylcysteine ​​preparation according to claim 5, characterized in that: The steering assembly comprises an annular protective cover (14), an incomplete gear ring (17) is installed in the annular protective cover (14), the upper end of each rotating shaft extends into the annular protective cover (14) and is installed with a steering gear (18), and each steering gear (18) is meshed with the incomplete gear ring (17), an energy-saving motor (11) is installed on the upper end surface of the annular protective cover (14), the output end of the energy-saving motor (11) extends into the annular protective cover (14) and is installed with a driving gear (28), and the driving gear (28) is meshed with the incomplete gear ring (17).

7. The method for preparing an acetylcysteine ​​preparation according to claim 1, comprising using an energy-saving airflow mill for producing the acetylcysteine ​​preparation according to any one of 1 to 6, characterized in that: The following steps are involved: S1. The acetylcysteine ​​raw material is initially crushed and passed through a 60-80 mesh sieve. Lactose, pregelatinized starch, sodium carboxymethyl starch, povidone, natural fruit juice concentrate, steviol glycosides, and magnesium stearate are respectively passed through a 80-100 mesh sieve for later use; S2, using a jet mill to crush the pretreated acetylcysteine, adjusting the air flow pressure to 0.6-1.0MPa, the feed rate to 10-20g / min, and the crushing time to 10-20min; S3. Accurately weigh the crushed acetylcysteine, lactose, and pregelatinized starch according to the prescription amount, place them in a high-speed stirring granulator, add an appropriate amount of polyvidone aqueous solution (concentration 5%-10%), stir at a speed of 400-600 rpm to form a soft material, and granulate the soft material through a 10-14 mesh sieve; S4, placing the obtained wet granules into a vacuum drying oven, and drying at 45-55°C until the moisture content is less than 2.5%; S5. The dried granules are sieved through a 14-18 mesh sieve, and then sodium carboxymethyl starch, natural fruit juice concentrate, steviol glycosides, and magnesium stearate are added, placed in a three-dimensional mixer, and mixed at a speed of 10-15 rpm for 8-12 minutes.

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