Synthesis method of histone deacetylase 4 small-molecule inhibitor and application of histone deacetylase 4 small-molecule inhibitor in resisting vascular endothelial aging

By synthesizing a cyclic dipeptide compound as a small molecule inhibitor of HDAC4, the problem of high toxicity and poor effect of HDAC4 inhibitors in the prior art has been solved, and significant anti-vascular endothelial cell aging effect is achieved, and good drug properties and safety are achieved.

CN119970736AActive Publication Date: 2025-05-13MACAU UNIV OF SCI & TECH +1
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Patent Information

Application Number
CN202510109977.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-23
Publication Date
2025-05-13
Estimated Expiration
2045-01-23

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Abstract

The invention relates to a synthesis method of a histone deacetylase 4 small-molecule inhibitor and application of the histone deacetylase 4 small-molecule inhibitor in resisting vascular endothelial aging. A novel HDAC4 small-molecule inhibitor is synthesized by a simple and efficient novel method, and the structural formula of the inhibitor is shown in the specification. The HDAC4 small-molecule inhibitor has strong affinity with HDAC4, can obviously reduce the expression quantity of HADC4 and P21 proteins and mRNA of vascular endothelial cells and the expression quantity of mRNA of inflammation-related proteins Il6, CCL2 and Il-1beta, has an obvious effect of resisting senescence of the vascular endothelial cells, has very good druggability and safety, and can be used for preparing an anti-aging medicine for preventing senescence of the vascular endothelial cells. The compound can be used for preparing medicines for treating vascular endothelial senescence and related diseases thereof. # imgabs0 #
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