Combination medicine for preventing and treating chronic cervicitis and preparation method thereof

Abstract

The invention discloses a combined medicine for preventing and treating chronic cervicitis and a preparation method thereof. The combined medicine comprises a scavenger I and a scavenger II, according to the combined medicine and the preparation method provided by the invention, comprehensive treatment is carried out by combining a mature therapy and an elimination therapy which are special for Uighur medicine, the vagina environment is changed, the local immune function is improved, and a treatment mode which is definite in curative effect, safe and low in price is provided for chronic cervicitis.

Description

Technical Field

[0001] The present invention relates to the technical field of cervicitis drugs, in particular to a combination drug for preventing and treating chronic cervicitis and a preparation method thereof. Background Art

[0002] Chronic cervicitis is the most common gynecological disease. It is more common in women who have given birth. The main clinical manifestations are increased leucorrhea, which is milky white or slightly yellow, or viscous and purulent, sometimes bloody or mixed with blood. The local manifestations of the cervix are cervical hypertrophy, endocervicitis, cervical glandular cysts and cervical squamous metaplasia.

[0003] At present, the level of integrated Chinese and Western medicine treatment for chronic cervicitis still relies too much on the accumulation of clinical experience. There is an urgent need to scientifically and objectively evaluate clinical efficacy, establish optimized plans and standardized diagnosis and treatment guidelines. Summary of the invention

[0004] To this end, the technical problem to be solved by the present invention is to provide a combination drug for preventing and treating chronic cervicitis and a preparation method, which combines the mature therapy and clearance therapy unique to Uyghur medicine for comprehensive treatment, changes the vaginal environment, improves local immune function, and provides a definite, safe and low-cost treatment method for chronic cervicitis.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] A combined medicine for preventing and treating chronic cervicitis, comprising:

[0007] A first scavenger, comprising mint, watermelon, nard, red amaranth, lavender, wild onion, iron chopstick, clove, aloe, water faucet, three tendons, longan, cinnamon, white pepper, lemongrass, castoreum, honey, ammonia resin, anise fruit, cumin, scabra resin, calamus, calamus, and usnea;

[0008] The second scavenger comprises senna leaves, myrrh, honey, medicinal watermelon, ammonia resin, aloe vera, licorice-flavored gum, and citrus fruit.

[0009] Furthermore, in parts by weight, the scavenger includes 3g of mint, 4g of medicinal watermelon, 4g of sweet pine, 3g of alihong, 3g of lavender, 4g of wild onion, 2g of iron chopsticks, 3g of cloves, 3g of aloe, 3g of water faucet, 2g of three tendons, 3g of longan, 3g of cinnamon, 3g of white pepper, 3g of lemongrass, 1g of castoreum, 30g of honey, 4g of ammonia resin, 2g of anise fruit, 3g of cumin, 2g of scabra, 3g of calamus, and 3g of usnea;

[0010] The second scavenger includes 14g of senna leaves, 7g of myrrh, 40g of honey, 7g of medicinal watermelon, 14g of ammonia, 14g of aloe, 7g of licorice flavored gum, and 7g of citrus aurantium.

[0011] Furthermore, the combination medicine also includes a maturation agent, a dehumidifying and anti-inflammatory powder and a flushing agent, and the scavenger 1 and scavenger 2 are used in combination with the maturation agent, the dehumidifying and anti-inflammatory powder and the flushing agent.

[0012] Specifically, after the abnormal physical constitution in the patient's body is gathered by the maturation agent, the scavenger one and scavenger two are taken at the same time to clear and expel the abnormal physical constitution, the dehumidifying and anti-inflammatory powder is applied to the cervix, and the vagina is flushed with the flushing agent to relieve the retention of substances in the patient's body, help the patient restore normal metabolism and blood flow, and improve immunity.

[0013] Furthermore, the maturation agent is made of Muniziqi granules.

[0014] Furthermore, the dehumidifying and anti-inflammatory powder includes pomegranate flowers, rose flowers, gallic acid seeds, coptis slices, and clove oil.

[0015] Furthermore, the dehumidifying and anti-inflammatory powder includes 35g of pomegranate flowers, 35g of rose flowers, 15g of gallic acid seeds, 15g of coptis slices, and 5mL of clove oil.

[0016] Furthermore, the preparation process of the dehumidifying and anti-inflammatory powder is as follows: pomegranate flowers, rose flowers, gallic acid seeds, and coptis slices are crushed according to the amount and passed through a 200-mesh sieve to make powder powder, and cotton balls coated with clove oil are mixed with the powder powder to form the dehumidifying and anti-inflammatory powder.

[0017] Furthermore, the flushing agent includes sandalwood dew, rose dew, pomegranate flower, pomegranate peel, nightshade dew, Tianshan violet, smilax china, gallic acid fruit, coptis slices, lantern dew, and alum.

[0018] Furthermore, the flushing agent includes 60 mL of sandalwood dew, 60 mL of rose dew, 3 g of pomegranate flower, 3 g of pomegranate peel, 60 mL of nightshade dew, 3 g of Tianshan violet, 3 g of sarsaparilla, 3 g of gallic acid, 1 g of coptis slices, 60 mL of brocade lantern dew, and 1 g of alum;

[0019] The preparation process of the flushing agent is as follows: pomegranate flowers, pomegranate peels, tianshan violets, smilax china, gallic acid seeds, coptis slices, and alum are respectively crushed according to the amount and then evenly mixed to form a powder mixture, and the powder mixture is processed with sandalwood dew, rose dew, nightshade fruit dew, and lantern dew for 12 hours to form the flushing agent.

[0020] A method for preparing a combined drug for preventing and treating chronic cervicitis, the composition comprising:

[0021] A first scavenger, comprising mint, watermelon, nard, red amaranth, lavender, wild onion, iron chopstick, clove, aloe, water faucet, three tendons, longan, cinnamon, white pepper, lemongrass, castoreum, honey, ammonia resin, anise fruit, cumin, scabra resin, calamus, calamus, and usnea;

[0022] A second scavenger, comprising senna leaves, myrrh, honey, medicinal watermelon, ammonia fat, aloe vera, licorice flavored gum, and citrus fruit;

[0023] The preparation method of the composition is as follows:

[0024] S1. Grind mint, watermelon, sweet pine, red amaranth, lavender, wild onion, iron chopsticks, cloves, water faucet, three tendons, longan, cinnamon, white pepper, lemongrass, castoreum, honey, ammonia resin, anise fruit, cumin, calamus, and usnea into powder, grind aloe, scabra resin, and fumitory into powder after passing through a 100-mesh sieve, and mix the above powders with honey to form a scavenger 1;

[0025] S2. Crush senna leaves, myrrh, honey, medicinal watermelon, and citron into powder; crush aloe, scabra, and licorice gum and pass through a 100-mesh sieve to form powder; soak myrrh in leek juice for 12 hours and then crush and sieve into powder; mix the above powders with honey to form a second scavenger.

[0026] The technical solution of the present invention achieves the following beneficial technical effects:

[0027] The abnormal physical constitution in the patient's body is gathered through the maturation agent, and then the abnormal physical constitution is cleared out by taking the scavenger one and scavenger two at the same time. The scavenger one and scavenger two mainly expel the abnormal physical constitution gathered in the blood vessel walls, tissue cells and female reproductive system (uterine body, cervix, vagina) through urination and defecation, change the vaginal environment, enhance local immune function, and provide an effective, safe and low-cost treatment for chronic cervicitis. DETAILED DESCRIPTION

[0028] Example 1

[0029] A combined medicine for preventing and treating chronic cervicitis comprises a first scavenger, a second scavenger, a ripening agent, a dehumidifying and anti-inflammatory powder and a flushing agent.

[0030] Among them, the scavenger one includes mint 3g, medicinal watermelon 4g, sweet myrtle 4g, alihong 3g, lavender 3g, wild onion 4g, iron chopstick 2g, clove 3g, aloe 3g, water faucet 3g, three tendons 2g, piper longituba 3g, cinnamon 3g, white pepper 3g, lemongrass 3g, castoreum 1g, honey 30g, ammonia resin 4g, anise fruit 2g, cumin 3g, scamonia resin 2g, osmanthus 3g, calamus 3g, and usnea 3g.

[0031] According to the above amounts, mint, medicinal watermelon, sweet myrtle, alihong, lavender, wild onion, iron chopsticks, cloves, polypodium vulgare, three tendons, longan, cinnamon, white pepper, lemongrass, castoreum, honey, ammonia resin, anise fruit, cumin, calamus, and usnea are crushed into powder, aloe, scabra resin, and osmanthus are crushed and passed through a 100-mesh sieve to form powder, the above powders are mixed with honey to form a scavenger 1, and made into honey pills. 5-7 pills are taken orally twice a day.

[0032] Cleanser 2 includes senna leaves 14g, myrrh 7g, honey 40g, watermelon 7g, ammonia resin 14g, aloe vera 14g, licorice flavored gum 7g, and western green fruit 7g.

[0033] According to the above amounts, senna leaves, myrrh, honey, medicinal watermelon, and citronella are crushed into powder; aloe, scabra, and licorice gum are crushed and passed through a 100-mesh sieve to form powder; myrrh is soaked in leek juice for 12 hours and then crushed and sieved into powder; the above powders are mixed with honey to form a second scavenger, which is made into honey pills and taken orally twice a day, 5 to 7 pills.

[0034] The mature agent uses Muniziqi granules, which are made into a decoction and taken orally in 12 grams three times a day.

[0035] The dehumidifying and anti-inflammatory powder includes 35g of pomegranate flowers, 35g of rose flowers, 15g of gallic acid seeds, 15g of coptis slices, and 5mL of clove oil. The pomegranate flowers, rose flowers, gallic acid seeds, and coptis slices are crushed according to the above quantities and passed through a 200-mesh sieve to make powder. When in use, mix the cotton ball coated with clove oil with the powder to form the dehumidifying and anti-inflammatory powder for application to the cervix.

[0036] The flushing agent includes 60mL of sandalwood dew, 60mL of rose dew, 3g of pomegranate flower, 3g of pomegranate peel, 60mL of nightshade dew, 3g of tianshan violet, 3g of sarsaparilla, 3g of gallic acid, 1g of coptis slices, 60mL of jindang dew, and 1g of alum; pomegranate flower, pomegranate peel, tianshan violet, sarsaparilla, gallic acid, coptis slices, and alum are crushed according to the amount and then evenly mixed to form a powder mixture, the powder mixture is prepared with sandalwood dew, rose dew, nightshade dew, and jindang dew for 12 hours, and boiled to form a flushing agent for flushing the vagina and vulva.

[0037] According to the patient's tongue, taste, pulse, skin, urine and stool, etc., it is divided into five types: increased mucus, sweet mucus, astringent mucus, decreased mucus, and gypsum mucus. Patients with astringent mucus have pale complexion, slightly thick lips, more subcutaneous fat, soft muscles, cold skin, cold and damp limbs, slightly blue sclera, and white tongue coating. The patient's original temperament was damp and cold, and due to long-term eating habits of cold and greasy food, it caused dry and cold abnormal astringent mucus. This mucus tends to be dry and cold, which will limit the function of normal mucus, increase the chance of body fluid forming precipitation and flowing in blood vessels, so in most cases, material retention will occur. This body fluid gathers in tissues and often causes difficulty in excretion. Long-term existence in the body causes the fluid to thicken and be retained in the blood vessel wall, tissue cells and various organs to form material retention, affecting local metabolism and normal blood flow, reducing immunity and causing this disease. The present invention is mainly aimed at treating patients with astringent mucus.

[0038] Uyghur medicine uses maturation agents to gather abnormal physical conditions in the patient's body, and then takes Clearer 1 and Clearer 2 at the same time to eliminate the abnormal physical conditions. Clearer 1 and Clearer 2 mainly eliminate the abnormal physical conditions gathered in the blood vessel walls, tissue cells and female reproductive system (uterine body, cervix, vagina) through urination and defecation. Some patients may experience short-term diarrhea for 2-3 days.

[0039] While taking the maturation agent and the clearing agent to adjust the physical condition, use the douche to perform vaginal washing and sitting baths once a day for 7 days as a course of treatment. The herbs in the douche have anti-inflammatory and anti-inflammatory effects, improve the vaginal microenvironment, reduce the amount of leucorrhea by adjusting the cold physical condition, and relieve itching.

[0040] While flushing the vagina with the douche, use the dehumidifying and anti-inflammatory powder to apply to the cervix. The medicine should be applied once a day for a course of 14 days. The herbs in the dehumidifying and anti-inflammatory powder have the effects of anti-inflammatory, anti-inflammatory, and tissue (epithelial) repair. Clove oil is a thermal oil that changes the vaginal environment, shrinks the vaginal wall, and improves local immune function.

[0041] Example 2

[0042] SPSS for Windows software package was used for data entry, verification and analysis. Count data were described using frequency and percentage, and χ 2 The basic information, clinical characteristics and therapeutic effects of the experimental group and the control group were analyzed by statistic test, Fisher's exact probability method and Wilcoxon rank sum test. The differences were considered statistically significant at P < 0.05.

[0043] Experimental group: treated with maturation agent, clearing agent 1 and clearing agent 2, and at the same time, the vagina was washed with flushing agent, the cervix was applied with dehumidifying and anti-inflammatory powder, and the cervix was treated with microwave therapy;

[0044] Control group: vaginal washing with normal saline + cervical microwave treatment.

[0045] 1. Analysis of the basic situation of the research object

[0046] A total of 73 female pain patients who met the inclusion criteria participated. The inclusion criteria were: ① meeting the Western medical diagnostic criteria for chronic cervicitis; ② meeting the Uyghur medical diagnosis of the physical condition required by this project; ③ informed consent, voluntary participation, and the process of obtaining informed consent complied with GCP regulations; ④ age under 60 years old; Exclusion criteria: ① pregnant women; ② those with allergic constitution or multiple drug allergies; ③ combined with serious primary diseases of the heart, brain, liver, kidney, hematopoietic system, endocrine system, etc.; ④ patients with mental illness; ⑤ those with severe conditions and it is difficult to make an accurate evaluation of the effectiveness and safety of the drugs; ⑥ suspected or confirmed history of alcohol or drug abuse, or other diseases that, according to the judgment of the researchers, reduce the possibility of inclusion or complicate inclusion, such as frequent changes in work environment, mental disorders, communication difficulties, etc., which are prone to loss to follow-up.

[0047] There were 32 patients in the experimental group and 41 patients in the control group. The conditions of the two groups of patients are shown in Table 1.

[0048] Table 1 Comparison of basic information of research subjects (n=73)

[0049]

[0050] *Analyzed using Wilcoxon rank sum test

[0051] As can be seen from the table, there was no statistically significant difference in age, comorbidities, and BMI between the experimental group and the control group (P>0.05).

[0052] In the experimental group, a total of 32 female pain patients who met the inclusion criteria participated. The basic information of the patients is shown in Table 2. It can be seen from the table that 26 patients (81.2%) were aged ≤45 years old, 17 patients (53.1%) had comorbidities, and as many as 78.1% of the patients were overweight.

[0053] Table 2 Basic information of the research subjects (n=32)

[0054]

[0055] *Analyzed using Wilcoxon rank sum test

[0056] 2. Comparison of clinical characteristics

[0057] Table 3 Comparison of clinical characteristics between the experimental group and the control group before treatment (n=73)

[0058]

[0059] #Use the exact probability method to perform analysis

[0060] As can be seen from Table 3, there were no statistically significant differences in blood routine, gynecological B-ultrasound, cervical size and abnormalities, and leucorrhea examination between the experimental group and the control group (P>0.05).

[0061] 3. Comparison of efficacy

[0062] After treatment, the comparison of the therapeutic effects between the experimental group and the control group is shown in Table 4.

[0063] Table 4 Comparison of the efficacy between the experimental group and the control group after treatment (n=73)

[0064]

[0065] *Analysis was performed using the Wilcoxon rank sum test, #Analysis was performed using the exact probability method

[0066] As can be seen from Table 4, after treatment, there were statistically significant differences in the cleanliness and amount of leucorrhea between the experimental group and the control group (P < 0.05), but no statistically significant difference in the color of leucorrhea (P > 0.05); the effective rate of auxiliary examinations in the experimental group was 93.7%, and that in the control group was 51.3%, and the difference between the two was statistically significant (P < 0.05); the effective rate of physical sign efficacy in both the experimental group and the control group was 100%.

[0067] After treatment, the cleanliness of leucorrhea returned to normal in most patients, the secretion was significantly reduced, and the experimental group was significantly better than the control group.

[0068] The physical signs of the experimental group before and after treatment are shown in Table 5.

[0069] Table 5 Physical signs of the subjects before and after Uyghur medicine treatment (n=32)

[0070]

[0071] After the combination drug treatment, the proportion of patients whose physical signs tended to be milder increased, their complexion became moist, their tongue was light red, their tongue coating was thin and white, and their pulse was smooth and vigorous, indicating that the organ functions of most patients gradually improved after treatment, and their yin and yang were balanced.

[0072] The efficacy of Uyghur medicine syndrome differentiation is shown in Table 6.

[0073] Table 6 The efficacy of Uyghur medicine treatment for the subjects (n=32)

[0074]

[0075] Before treatment, all patients' Uyghur syndrome differentiation typing was astringent mucus. After treatment, the patients' Uyghur syndrome differentiation typing changed, including 13 cases (40.6%) of dry heat, 12 cases (37.5%) of damp cold temperament, and 7 cases (21.9%) of bloody temperament. As can be seen from Table 6, the effective rate of auxiliary examination was 93.7%, and the effective rates of physical sign efficacy and Uyghur medicine constitution efficacy were both 100%.

[0076] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the claims of this patent application.

Claims

1. A combination drug for preventing and treating chronic cervicitis, characterized in that: include: A first scavenger, comprising mint, watermelon, nard, red amaranth, lavender, wild onion, iron chopstick, clove, aloe, water faucet, three tendons, longan, cinnamon, white pepper, lemongrass, castoreum, honey, ammonia resin, anise fruit, cumin, scabra resin, calamus, calamus, and usnea; The second scavenger comprises senna leaves, myrrh, honey, medicinal watermelon, ammonia resin, aloe vera, licorice-flavored gum, and citrus fruit.

2. The combination drug according to claim 1, characterized in that In parts by weight, the scavenger includes 3g of mint, 4g of medicinal watermelon, 4g of sweet pine, 3g of alihong, 3g of lavender, 4g of wild onion, 2g of iron chopsticks, 3g of cloves, 3g of aloe, 3g of water faucet, 2g of three tendons, 3g of longan, 3g of cinnamon, 3g of white pepper, 3g of lemongrass, 1g of castoreum, 30g of honey, 4g of ammonia resin, 2g of anise fruit, 3g of cumin, 2g of scabra, 3g of calamus, and 3g of usnea; The second scavenger includes 14g of senna leaves, 7g of myrrh, 40g of honey, 7g of medicinal watermelon, 14g of ammonia, 14g of aloe, 7g of licorice flavored gum, and 7g of citrus aurantium.

3. The combination drug according to claim 1, characterized in that The combined medicine also includes a maturation agent, a dehumidifying and anti-inflammatory powder and a flushing agent, and the scavenger 1 and scavenger 2 are used in combination with the maturation agent, the dehumidifying and anti-inflammatory powder and the flushing agent.

4. The combination drug according to claim 3, characterized in that The ripening agent is Muniziqi granules.

5. The combination drug according to claim 3, characterized in that: The dehumidifying and anti-inflammatory powder comprises pomegranate flowers, rose flowers, gallic acid seeds, coptis root slices and clove oil.

6. The combination drug according to claim 5, characterized in that The dehumidifying and anti-inflammatory powder comprises 35g of pomegranate flower, 35g of rose flower, 15g of gallic acid fruit, 15g of coptis root tablets, and 5mL of clove oil; The preparation process of the dehumidifying and anti-inflammatory powder is as follows: pomegranate flowers, rose flowers, gallic acid seeds, and coptis slices are crushed according to the amount and passed through a 200-mesh sieve to make powder powder, and cotton balls coated with clove oil are mixed with the powder powder to form the dehumidifying and anti-inflammatory powder.

7. The combination drug according to claim 3, characterized in that The flushing agent includes sandalwood dew, rose dew, pomegranate flower, pomegranate peel, nightshade fruit dew, Tianshan violet, smilax china, gallic acid fruit, coptis slices, lantern dew and alum.

8. The combination drug according to claim 7, characterized in that The flushing agent includes 60 mL of sandalwood dew, 60 mL of rose dew, 3 g of pomegranate flower, 3 g of pomegranate peel, 60 mL of nightshade dew, 3 g of Tianshan violet, 3 g of sarsaparilla, 3 g of gallic acid, 1 g of coptis slices, 60 mL of brocade lantern dew, and 1 g of alum; The preparation process of the flushing agent is as follows: pomegranate flowers, pomegranate peels, tianshan violets, smilax china, gallic acid seeds, coptis slices, and alum are respectively crushed according to the amount and then evenly mixed to form a powder mixture, and the powder mixture is processed with sandalwood dew, rose dew, nightshade fruit dew, and lantern dew for 12 hours to form the flushing agent.

9. A method for preparing a combined drug for preventing and treating chronic cervicitis, characterized in that: The composition comprises: A first scavenger, comprising mint, watermelon, nard, red amaranth, lavender, wild onion, iron chopstick, clove, aloe, water faucet, three tendons, longan, cinnamon, white pepper, lemongrass, castoreum, honey, ammonia resin, anise fruit, cumin, scabra resin, calamus, calamus, and usnea; A second scavenger, comprising senna leaves, myrrh, honey, medicinal watermelon, ammonia fat, aloe vera, licorice flavored gum, and citrus fruit; The preparation method of the composition is as follows: S1. Grind mint, watermelon, sweet pine, red amaranth, lavender, wild onion, iron chopsticks, cloves, water faucet, three tendons, longan, cinnamon, white pepper, lemongrass, castoreum, honey, ammonia resin, anise fruit, cumin, calamus, and usnea into powder, grind aloe, scabra resin, and fumitory into powder after passing through a 100-mesh sieve, and mix the above powders with honey to form a scavenger 1; S2. Crush senna leaves, myrrh, honey, medicinal watermelon, and citron into powder; crush aloe, scabra, and licorice gum and pass through a 100-mesh sieve to form powder; soak myrrh in leek juice for 12 hours and then crush and sieve into powder; mix the above powders with honey to form a second scavenger.

Images