Traditional Chinese medicine composition for treating alopecia seborrhoeica and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating alopecia seborrhoeica. Comprising the following raw materials: 10-60 parts of oriental wormwood, 8-50 parts of rhizoma atractylodis, 10-90 parts of radix angelicae, 6-70 parts of dandelion, 8-90 parts of poria cocos, 10-50 parts of semen coicis, 5-40 parts of radix trichosanthis, 10-60 parts of astragalus membranaceus, 5-50 parts of cortex moutan, 3-40 parts of scutellaria baicalensis, 3-30 parts of asarum, 5-40 parts of agastache rugosus, 10-30 parts of honeysuckle stem, 6-50 parts of lophatherum gracile, 10-50 parts of angelica sinensis, 6-60 parts of rhizoma drynariae, 10-40 parts of white mulberry root-bark, 6-50 parts of divaricate saposhnikovia root, 5-40 parts of scorched hawthorn fruit, 6-60 parts of ligusticum and 5-40 parts of platycodon grandiflorum. According to the present invention, the external application product with effects of dampness removing, fat removing and orifice opening is developed according to the fundamental pathogenesis of excessive dampness, can directly reach the disease site, can promote the blood circulation of the scalp, can dredge the channels, and can regulate qi and blood, such that the effects of blood circulation promoting, blood stasis removing, new generation promoting, and hair regeneration promoting are provided.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating seborrheic alopecia and a preparation method thereof. Background Art

[0002] Alopecia belongs to the category of "alopecia areata", "oily wind" and "hair rot" in traditional Chinese medicine. It was first recorded in the book "Inner Canon of Medicine". Its causes are complicated, such as wind and dampness invading the skin surface; or mental tension and emotional disorder; or improper diet, eating rich and greasy food, smoking and drinking spicy food, damaging the spleen and stomach, and generating phlegm and turbidity; or undisciplined life, overwork and staying up late, and liver and kidney deficiency over time; or long-term illness and physical weakness and lack of nourishment. Its onset is often considered to be closely related to the liver, kidney, qi and blood. The etiology and pathogenesis of alopecia have two ends: deficiency and excess. Deficiency is mostly caused by liver and kidney deficiency, blood deficiency, wind and dryness, hair loss, and loss of nourishment; excess is mostly caused by dampness, turbidity, phlegm and heat, blood stasis, and isolation of qi and blood, which will fall if they are not smooth. The author believes that there are few pure deficiency and excess syndromes in clinical practice, and there are many cases of mixed deficiency and excess or deficiency in the main and excess in the superficial. Most patients with seborrheic alopecia have dampness-prone constitutions, or they have an unhealthy diet and eat too much fatty and sweet food, which causes dampness and heat in the body. The dampness and heat rise to the top of the head, eroding the hair roots, blocking the hair pores, affecting hair growth and causing hair loss. Symptoms include greasy and shiny hair, excessive hair loss, slow growth of new hair, increasingly thin and sparse hair on the top of the head, and upward push of the temples and the front hairline.

[0003] Seborrheic alopecia (SA) is mainly caused by abnormalities in androgens and their receptors, and is also related to genetic and psychological factors. The clinical manifestations are increased scalp oil, a large amount of dandruff, and gradual hair loss on the forehead and top of the head. According to incomplete statistics, there are 250 million people with hair loss in the country, among which the total prevalence of seborrheic alopecia is 12.8%, among which the incidence rate in men is higher, about 21.3%, and the prevalence rate in women is 6.0%. There are many people affected, and they are getting younger. The incidence rate is increasing year by year, so the expected application prospects of seborrheic alopecia product research and development are very impressive. At present, the research on seborrheic alopecia has been carried out to the molecular level, and new therapeutic drugs are constantly emerging, showing a trend of combining traditional Chinese and Western medicine.

[0004] Seborrheic alopecia is an androgen-dependent hereditary hair loss disease. The main pathogenesis is that androgens bind to the receptors on the hair follicles on the forehead, causing damage to the hair follicles and premature entry of the hair into the resting phase. Its onset may also be related to endocrine dysfunction, genetics, fungal infection, and inflammation. In addition, some factors such as psychological factors, immune response, and changes in blood rheology can also accelerate the occurrence and development of seborrheic alopecia.

[0005] Drug treatment is currently the main means of treating seborrheic alopecia. The most commonly used is minoxidil, which is a non-specific drug for treating hair loss and is a first-line topical drug approved by the FDA for the treatment of seborrheic alopecia. Clinical data show that the total effective rate of male patients with seborrheic alopecia is 91%, and that of female patients is 89%. The best therapeutic effect usually occurs after 1 year. The mechanisms for preventing and treating hair loss include: opening potassium ion channels, inhibiting calcium ion influx, reducing the inhibition of hair growth by epidermal growth factor, promoting the proliferation and differentiation of hair follicle epithelial cells, upregulating vascular endothelial growth factor and improving local blood supply. However, it may cause facial and limb hypertrichosis during use.

[0006] Finasteride is a type II 5-α reductase selective inhibitor that can reduce the conversion of testosterone into dihydrotestosterone, which has a stronger receptor binding affinity, thereby reducing the effect of androgens on hair loss. A long-term clinical trial in Europe found that finasteride can sustainably improve hair growth, but it has adverse reactions such as causing sexual dysfunction, transient sperm reduction, and abnormal male breast development. Summary of the invention

[0007] In order to solve the above technical problems, an embodiment of the present invention provides a Chinese medicine composition for treating seborrheic alopecia and a preparation method thereof.

[0008] To achieve the above object, the embodiments of the present invention adopt the following technical solutions:

[0009] On the one hand, the present application provides a traditional Chinese medicine composition for treating seborrheic alopecia, comprising the following raw materials, by weight: 10-60 parts of Artemisia Capillaris, 8-50 parts of Atractylodes macrocephala, 10-90 parts of Angelica dahurica, 6-70 parts of Taraxacum mongolicum, 8-90 parts of Poria cocos, 10-50 parts of Coix seeds, 5-40 parts of Radix Trichosanthis, 10-60 parts of Astragalus, 5-50 parts of Cortex Moutan, 3-40 parts of Scutellaria baicalensis, 3-30 parts of Asarum, 5-40 parts of Patchouli, 10-30 parts of Honeysuckle Caulis, 6-50 parts of Lophatherum gracile, 10-50 parts of Angelica sinensis, 6-60 parts of Drynaria fortunei, 10-40 parts of Morus alba bark, 6-50 parts of Saposhnikovia divaricata, 5-40 parts of Crataegus pinnatifida, 6-60 parts of Ligusticum chuanxiong and 5-40 parts of Platycodon grandiflorum.

[0010] In some embodiments, the following raw materials are included by weight: 10-50 parts of Artemisia capillaris, 10-50 parts of Atractylodes lancea, 20-90 parts of Angelica dahurica, 10-70 parts of Taraxacum, 10-90 parts of Poria, 10-40 parts of Coix seeds, 8-40 parts of Radix Trichosanthis, 10-50 parts of Astragalus, 10-50 parts of Moutan bark, 8-40 parts of Scutellaria baicalensis, 8-30 parts of Asarum, 10-40 parts of Patchouli, 10-25 parts of Honeysuckle vine, 10-50 parts of Lophatherum gracile, 15-50 parts of Angelica sinensis, 10-60 parts of Drynaria fortunei, 15-40 parts of Morus alba bark, 10-50 parts of Saposhnikovia divaricata, 10-40 parts of Crataegus pinnatifida, 10-60 parts of Ligusticum chuanxiong and 8-40 parts of Platycodon grandiflorum.

[0011] In some embodiments, the following raw materials are included by weight: 15-50 parts of Artemisia capillaris, 10-40 parts of Atractylodes lancea, 20-70 parts of Angelica dahurica, 20-70 parts of Taraxacum mongolicum, 20-80 parts of Poria cocos, 10-35 parts of Coix seeds, 10-30 parts of Radix Trichosanthis, 15-60 parts of Astragalus, 20-50 parts of Cortex Moutan, 15-40 parts of Scutellaria baicalensis, 10-30 parts of Asarum, 20-40 parts of Patchouli, 10-20 parts of Honeysuckle vine, 20-50 parts of Lophatherum gracile, 20-50 parts of Angelica sinensis, 20-60 parts of Drynaria fortunei, 20-40 parts of Morus alba bark, 20-50 parts of Saposhnikovia divaricata, 15-40 parts of Charred Crataegus pinnatifida, 20-60 parts of Ligusticum chuanxiong and 10-40 parts of Platycodon grandiflorum.

[0012] In some embodiments, the following raw materials are included by weight: 20-40 parts of Artemisia capillaris, 20-30 parts of Atractylodes lancea, 40-60 parts of Angelica dahurica, 40-60 parts of Taraxacum mongolicum, 50-80 parts of Poria cocos, 20-30 parts of Coix seeds, 15-30 parts of Radix Trichosanthis, 30-40 parts of Astragalus, 40-50 parts of Cortex Moutan, 20-40 parts of Scutellaria baicalensis, 20-30 parts of Asarum, 30-40 parts of Patchouli, 15-20 parts of Honeysuckle vine, 30-40 parts of Lophatherum gracile, 30-40 parts of Angelica sinensis, 30-40 parts of Drynaria fortunei, 30-40 parts of Morus alba bark, 30-40 parts of Saposhnikovia divaricata, 20-30 parts of Charred Crataegus pinnatifida, 40-50 parts of Ligusticum chuanxiong and 20-30 parts of Platycodon grandiflorum.

[0013] In some embodiments, the following raw materials are included, by weight: 15 parts of Artemisia Capillaris, 8 parts of Atractylodes, 12 parts of Angelica dahurica, 20 parts of Taraxacum, 15 parts of Poria, 15 parts of Coix seeds, 8 parts of Radix Trichosanthis, 15 parts of Astragalus, 10 parts of Moutan Bark, 10 parts of Scutellaria baicalensis, 12 parts of Asarum, 15 parts of Patchouli, 20 parts of Honeysuckle Caulis, 30 parts of Lophatherum gracile, 15 parts of Angelica sinensis, 25 parts of Drynaria fortunei, 20 parts of Morus alba, 15 parts of Saposhnikovia divaricata, 20 parts of Crataegus pinnatifida, 18 parts of Ligusticum chuanxiong and 8 parts of Platycodon grandiflorum.

[0014] On the other hand, the present application also provides a method for preparing a Chinese medicine composition for treating seborrheic alopecia, comprising the following steps:

[0015] A. Weigh Artemisia capillaris, Atractylodes lancea, Angelica dahurica, Taraxacum mongolicum, Poria cocos, Coix seeds, Radix Trichosanthis, Radix Astragali, Cortex Moutan, Radix Scutellariae, Asarum, Patchouli, Caulis Lonicerae, Folium Lophatherum, Angelica sinensis, Drynariae Rhizoma, Cortex Mori, Saposhnikovia divaricata, Crataegus pinnatifida, Ligusticum chuanxiong and Platycodon grandiflorum by weight, mix well, add 2-4 times of the weight of the medicinal materials in water, soak for 0.5-1h, decoct twice, decoct for 20-40min each time, and filter to obtain a filtrate;

[0016] B. Adding pharmaceutically acceptable excipients to the filtrate obtained in step A to prepare a pharmaceutical preparation commonly used in pharmacy.

[0017] In order to realize the above dosage forms, pharmaceutically acceptable excipients need to be added when preparing these dosage forms, such as fillers, lubricants, suspending agents, preservatives, etc. Fillers include starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose, etc. Lubricants include magnesium stearate, sodium lauryl sulfate, talc, butylene glycol, sodium hyaluronate, silicon dioxide, etc. Suspending agents include polyvinyl pyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methylcellulose, etc. Preservatives include parabens, benzoic acid, sodium benzoate, sorbic acid and its salts, benzalkonium bromide, chloroethidine acetate, eucalyptus oil, butylene glycol, etc.

[0018] Artemisia capillaris: bitter and spicy in taste, slightly cold in nature, enters the spleen, stomach, liver and gallbladder meridians.

[0019] Atractylodes: spicy and bitter in taste, warm in nature, enters the spleen, stomach and liver meridians.

[0020] Angelica dahurica: spicy, warm in nature, enters the lung, spleen and stomach meridians.

[0021] Dandelion: bitter and sweet in taste, cold in nature, and enters the liver and stomach meridians.

[0022] Poria: sweet and light in taste, neutral in nature, enters the heart, lung, spleen and kidney meridians.

[0023] Job's tears: sweet and light in taste, cool in nature, and enters the spleen, stomach, and lung meridians.

[0024] Radix Trichosanthis: sweet, slightly bitter in taste, slightly cold in nature, enters the lung and stomach meridians.

[0025] Astragalus: sweet in taste, slightly warm in nature, enters the spleen and lung meridians.

[0026] Cortex Moutan: bitter and spicy in taste, slightly cold in nature, enters the heart, liver and kidney meridians.

[0027] Scutellaria baicalensis: bitter in taste, cold in nature, enters the lung, gallbladder, spleen, large intestine and small intestine meridians.

[0028] Asarum: spicy in taste, warm in nature, enters the heart, lung and kidney meridians.

[0029] Patchouli: spicy, warm in nature, enters the spleen, stomach and lung meridians.

[0030] Honeysuckle vine: sweet in taste, cold in nature, enters the lung and stomach meridians.

[0031] Light bamboo leaves: sweet and light in taste, cold in nature, enters the heart, lung, stomach and bladder meridians.

[0032] Angelica: sweet and spicy in taste, warm in nature, enters the liver, heart and spleen meridians.

[0033] Drynaria fortunei: bitter in taste, warm in nature. Enters the kidney and liver meridians.

[0034] Morus alba bark: sweet in taste, cold in nature, enters the lung and spleen meridians.

[0035] Saposhnikovia divaricata: spicy and sweet in taste, slightly warm in nature, enters the bladder, spleen and liver meridians.

[0036] Scorched hawthorn: sour in taste, slightly warm in nature, and enters the stomach meridian, spleen meridian, and liver meridian.

[0037] Ligusticum chuanxiong: spicy in taste, warm in nature, enters the bladder meridian.

[0038] Platycodon: bitter and spicy in taste, neutral in nature, enters the lung meridian.

[0039] The present invention mainly treats seborrheic alopecia, seborrheic dermatitis and folliculitis, which are mostly caused by spleen deficiency and dampness stagnation, which are manifested as excessive oil secretion, blockage of orifices, and heat generation over time, leading to the occurrence of seborrheic dermatitis, seborrheic alopecia and folliculitis. Modern diets are mostly overnutrition. Due to the pressure of life, people often eat and drink without restraint, which damages the spleen and causes endogenous dampness and turbidity. Heat generation over time causes the skin of the head and face to become ill. It is advisable to treat mainly by strengthening the spleen and removing dampness, and cooperate with dredging the meridians and dispersing the knots, clearing away heat and discharging pus as the method.

[0040] In the present invention, Artemisia capillaris tastes bitter and pungent, is slightly cold in nature, can remove dampness and reduce jaundice, detoxify and treat sores, Atractylodes lancea is bitter, warm and can dry dampness to remove dampness and turbidity, enters the spleen and stomach meridians, and is good at drying dampness and strengthening the spleen. Pharmacological studies have shown that Atractylodes lancea alcohol has the effect of promoting gastrointestinal motility and has a contractile effect on gastric smooth muscle. The two medicines are used together with cold and warm to remove dampness and turbidity, strengthen the spleen qi, and are combined with Poria cocos and Coix seeds to strengthen the spleen, strengthen the power of removing dampness without hurting the body; Angelica dahurica is fragrant and dry, is good at removing dampness evil in the Yangming meridian, is pungent and warm to move the surface, and can be used together with Atractylodes lancea to open the skin surface and induce sweating to remove dampness, reduce swelling and discharge pus; Taraxacum mongolicum and Radix Trichosanthis can reduce swelling and disperse nodules, reduce swelling and discharge pus, and take both the symptoms and the root causes into consideration. The seven medicines are the monarch medicines.

[0041] Astragalus can replenish Qi and has the effect of expelling toxins and promoting tissue regeneration. It helps Angelica dahurica and Radix Trichosanthis to discharge pus, strengthen the body and expel toxins. Cortex Moutan, Scutellaria baicalensis, Lonicera japonica, and Lophatherum gracile can clear away heat, activate blood circulation and unclog the meridians. When evil pathogens are stagnant between the skin and pores, it is assisted by Asarum pungent and warm to disperse the stagnation and unclog the meridians, while Patchouli pungent, warm and aromatic can invigorate the spleen. Patchouli volatile oil can promote gastric juice secretion, enhance digestion, and prevent Scutellaria baicalensis and other cold medicines from excessively damaging the spleen. It is a minister medicine.

[0042] Angelica sinensis promotes blood circulation, reduces swelling and relieves pain, while Drynaria fortunei warms and nourishes the body, and together with Astragalus membranaceus, they work to strengthen the body and expel toxins. The lungs govern the skin and fur, while Morus alba bark is sweet and cold and belongs to the lung meridian, which can drain dampness and heat from the skin and muscles. Saposhnikovia divaricata has a pungent flavor and can disperse moisture and relieve itching in the muscles. Scorched hawthorn promotes blood circulation, removes blood stasis, helps food, strengthens the spleen and removes turbidity. Pharmacological studies have found that the fatty acids contained in hawthorn can promote fat digestion, increase the secretion of gastric digestive enzymes, and treat the lungs and stomach together, with all the medicines acting as the messenger.

[0043] The spice and warming effect of Ligusticum chuanxiong is used to assist Angelica dahurica, Saposhnikovia divaricata and Asarum in warming and dispelling dampness. Modern pharmacological studies have found that Ligusticum chuanxiong alcohol extract has antibacterial effects on common pathogenic dermatophytes; Platycodon grandiflorum is used to clear the lungs and discharge pus. The combination of these medicines can treat both the symptoms and the root causes.

[0044] That is, the present invention develops an external-use product with the effects of removing dampness, reducing fat and opening the orifices by targeting the fundamental pathogenesis of dampness. It can directly reach the affected area, promote blood circulation in the skin, dredge the meridians, and regulate qi and blood, thereby playing the role of promoting blood circulation, removing blood stasis, and promoting new blood. It has the effect of reducing skin oil secretion and promoting hair regeneration. DETAILED DESCRIPTION

[0045] The technical solutions in some embodiments of the present disclosure are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present disclosure, not all of the embodiments. Based on the embodiments provided by the present disclosure, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present disclosure.

[0046] Example 1

[0047] Weigh 10g of Artemisia capillaris, 8g of Atractylodes lancea, 10g of Angelica dahurica, 6g of Taraxacum, 8g of Poria, 10g of Coix seed, 5g of Radix Trichosanthis, 10g of Astragalus, 5g of Cortex Moutan, 3g of Scutellaria baicalensis, 3g of Asarum, 5g of Patchouli, 10g of Lonicera japonica, 6g of Lophatherum gracile, 10g of Angelica sinensis, 6g of Drynaria fortunei, 10g of Morus alba, 6g of Saposhnikovia divaricata, 5g of Crataegus pinnatifida, 6g of Ligusticum chuanxiong and 5g of Platycodon grandiflorum, mix well, add 2 times the weight of the medicinal materials into water, soak for 0.5h, decoct twice, each time for 20min, filter to obtain the filtrate, add 6g of butylene glycol and 6g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0048] Example 2

[0049] Weigh 20g of Artemisia capillaris, 15g of Atractylodes lancea, 20g of Angelica dahurica, 18g of Taraxacum, 15g of Poria, 20g of Coix seed, 10g of Radix Trichosanthis, 20g of Astragalus, 10g of Cortex Moutan, 10g of Scutellaria baicalensis, 10g of Asarum, 10g of Patchouli, 15g of Lonicera japonica, 10g of Lophatherum gracile, 15g of Angelica sinensis, 10g of Drynaria fortunei, 15g of Morus alba, 10g of Saposhnikovia divaricata, 10g of Crataegus pinnatifida, 8g of Ligusticum chuanxiong and 10g of Platycodon grandiflorum, mix well, add 2 times the weight of the medicinal materials into water, soak for 0.5h, decoct twice, each time for 25min, filter to obtain the filtrate, add butylene glycol and sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0050] Example 3

[0051] Weigh 30g of Artemisia capillaris, 20g of Atractylodes lancea, 30g of Angelica dahurica, 30g of Taraxacum mongolicum, 40g of Poria, 25g of Coix seed, 15g of Radix Trichosanthis, 20g of Astragalus, 15g of Cortex Moutan, 20g of Scutellaria baicalensis, 10g of Asarum, 20g of Patchouli, 15g of Honeysuckle Caulis, 20g of Lophatherum gracile, 15g of Angelica sinensis, 20g of Drynaria fortunei, 15g of Morus alba, 20g of Saposhnikovia divaricata, 10g of Crataegus pinnatifida, 20g of Ligusticum chuanxiong and 15g of Platycodon grandiflorum, mix well, add 3 times the weight of the medicinal materials in water, soak for 40min, decoct twice, each time for 30min, filter to obtain the filtrate, add 15g of butylene glycol and 15g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0052] Example 4

[0053] Weigh 12g of Artemisia capillaris, 8g of Atractylodes lancea, 10g of Angelica dahurica, 13g of Taraxacum, 15g of Poria, 10g of Coix seed, 8g of Radix Trichosanthis, 10g of Astragalus, 10g of Cortex Moutan, 8g of Scutellaria baicalensis, 5g of Asarum, 8g of Patchouli, 12g of Lonicera japonica, 8g of Lophatherum gracile, 12g of Angelica sinensis, 12g of Drynaria fortunei, 12g of Morus alba, 8g of Saposhnikovia divaricata, 8g of Crataegus pinnatifida, 10g of Ligusticum chuanxiong and 8g of Platycodon grandiflorum, mix well, add 2 times the weight of the medicinal materials into water, soak for 0.5h, decoct twice, each time for 20min, filter to obtain the filtrate, add 8g of butylene glycol and 6g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0054] Example 5

[0055] Weigh 60g of Artemisia capillaris, 50g of Atractylodes lancea, 90g of Angelica dahurica, 70g of Taraxacum mongolicum, 90g of Poria, 50g of Coix seed, 40g of Radix Trichosanthis, 60g of Astragalus, 50g of Cortex Moutan, 40g of Scutellaria baicalensis, 30g of Asarum, 40g of Patchouli, 30g of Honeysuckle, 50g of Lophatherum gracile, 50g of Angelica sinensis, 60g of Drynaria fortunei, 40g of Morus alba, 50g of Saposhnikovia divaricata, 40g of Crataegus pinnatifida, 60g of Ligusticum chuanxiong and 40g of Platycodon grandiflorum, mix well, add 4 times the weight of the medicinal materials in water, soak for 1h, decoct twice, each time for 40min, filter to obtain the filtrate, add butylene glycol and sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0056] Example 6

[0057] Weigh 30g of Artemisia capillaris, 30g of Atractylodes lancea, 50g of Angelica dahurica, 35g of Taraxacum, 40g of Poria, 30g of Coix seed, 20g of Radix Trichosanthis, 30g of Astragalus, 30g of Cortex Moutan, 20g of Scutellaria baicalensis, 15g of Asarum, 20g of Patchouli, 15g of Honeysuckle, 25g of Lophatherum gracile, 20g of Angelica sinensis, 40g of Drynaria fortunei, 20g of Morus alba, 30g of Saposhnikovia divaricata, 20g of Crataegus pinnatifida, 30g of Ligusticum chuanxiong and 20g of Platycodon grandiflorum, mix well, add 3 times the weight of the medicinal materials in water, soak for 40min, decoct twice, each time for 30min, filter to obtain the filtrate, add 30g of butylene glycol and 20g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0058] Example 7

[0059] Weigh 35g of Artemisia capillaris, 35g of Atractylodes lancea, 40g of Angelica dahurica, 40g of Taraxacum, 45g of Poria, 35g of Coix seed, 25g of Radix Trichosanthis, 35g of Astragalus, 35g of Cortex Moutan, 25g of Scutellaria baicalensis, 20g of Asarum, 25g of Patchouli, 20g of Honeysuckle Caulis, 20g of Lophatherum gracile, 25g of Angelica sinensis, 45g of Drynaria fortunei, 25g of Morus alba, 35g of Saposhnikovia divaricata, 25g of Crataegus pinnatifida, 35g of Ligusticum chuanxiong and 25g of Platycodon grandiflorum, mix well, add 3 times the weight of the medicinal materials in water, soak for 40min, decoct twice, each time for 30min, filter to obtain the filtrate, add 35g of butylene glycol and 25g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0060] Example 8

[0061] Weigh 40g of Artemisia capillaris, 45g of Atractylodes lancea, 55g of Angelica dahurica, 50g of Taraxacum, 50g of Poria, 40g of Coix seed, 30g of Radix Trichosanthis, 40g of Astragalus, 40g of Cortex Moutan, 30g of Scutellaria baicalensis, 20g of Asarum, 25g of Patchouli, 20g of Honeysuckle, 25g of Lophatherum gracile, 20g of Angelica sinensis, 45g of Drynaria fortunei, 20g of Morus alba, 30g of Saposhnikovia divaricata, 15g of Crataegus pinnatifida, 35g of Ligusticum chuanxiong and 20g of Platycodon grandiflorum, mix well, add 3 times the weight of the medicinal materials in water, soak for 45min, decoct twice, each time for 40min, filter to obtain the filtrate, add 35g of butylene glycol and 30g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0062] Example 9

[0063] Weigh 12g of Artemisia capillaris, 8g of Atractylodes lancea, 15g of Angelica dahurica, 8g of Taraxacum, 8g of Poria, 12g of Coix seed, 8g of Radix Trichosanthis, 10g of Astragalus, 10g of Cortex Moutan, 5g of Scutellaria baicalensis, 6g of Asarum, 8g of Patchouli, 15g of Lonicera japonica, 8g of Lophatherum gracile, 12g of Angelica sinensis, 8g of Drynaria fortunei, 12g of Morus alba, 8g of Saposhnikovia divaricata, 10g of Crataegus pinnatifida, 12g of Ligusticum chuanxiong and 6g of Platycodon grandiflorum, mix well, add 2 times the weight of the medicinal materials in water, soak for 0.5h, decoct twice, each time for 20min, filter to obtain the filtrate, add 8g of butylene glycol and 8g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0064] Example 10

[0065] Weigh 55g of Artemisia capillaris, 45g of Atractylodes lancea, 85g of Angelica dahurica, 65g of Taraxacum, 85g of Poria, 45g of Coix seed, 5-40g of Radix Trichosanthis, 55g of Astragalus, 45g of Cortex Moutan, 35g of Scutellaria baicalensis, 25g of Asarum, 35g of Patchouli, 25g of Honeysuckle Caulis, 45g of Lophatherum gracile, 45g of Angelica sinensis, 55g of Drynaria fortunei, 35g of Morus alba, 45g of Saposhnikovia divaricata, 35g of Crataegus pinnatifida, 55g of Ligusticum chuanxiong and 35g of Platycodon grandiflorum, mix well, add 3 times the weight of the medicinal materials in water to soak for 50min, decoct twice, each time for 35min, filter to obtain the filtrate, add 35g of butylene glycol and 35g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0066] Embodiment 11

[0067] Artemisia capillaris 15g, atractylodes 8g, angelica 12g, dandelion 20g, poria 15g, coix seed 15g, root of trichosanthes 8g, astragalus 15g, moutan bark 10g, scutellaria 10g, asarum 12g, patchouli 15g, honeysuckle 20g, loofah 30g, angelica 15g, drynaria 25g, mulberry bark 20g, siler 15g, charred hawthorn 20g, ligusticum 18g and platycodon 8g are mixed, and 2-4 times the weight of the medicinal materials are added to soak for 0.5-1h, decocted twice, each time for 20-40min, filtered to obtain the filtrate, and pharmaceutically acceptable excipients are added to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0068] Example 12

[0069] Weigh 50g of Artemisia capillaris, 40g of Atractylodes lancea, 80g of Angelica dahurica, 60g of Taraxacum, 80g of Poria, 40g of Coix seed, 30g of Radix Trichosanthis, 50g of Astragalus, 40g of Moutan bark, 30g of Scutellaria baicalensis, 20g of Asarum, 30g of Patchouli, 20g of Honeysuckle vine, 40g of Lophatherum gracile, 40g of Angelica sinensis, 50g of Drynaria fortunei, 30g of Morus alba, 40g of Saposhnikovia divaricata, 30g of Crataegus pinnatifida, 50g of Ligusticum chuanxiong and 30g of Platycodon grandiflorum, mix well, add 4 times the weight of the medicinal materials in water, soak for 1h, decoct twice, each time for 30min, filter to obtain the filtrate, add 20g of butylene glycol and 20g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0070] Embodiment 13

[0071] Weigh 40g of Artemisia capillaris, 30g of Atractylodes lancea, 70g of Angelica dahurica, 50g of Taraxacum, 70g of Poria, 30g of Coix seed, 20g of Radix Trichosanthis, 40g of Astragalus, 30g of Cortex Moutan, 20g of Scutellaria baicalensis, 10g of Asarum, 20g of Patchouli, 10g of Honeysuckle Caulis, 30g of Lophatherum gracile, 30g of Angelica sinensis, 40g of Drynaria fortunei, 20g of Morus alba, 30g of Saposhnikovia divaricata, 20g of Crataegus pinnatifida, 40g of Ligusticum chuanxiong and 20g of Platycodon grandiflorum, mix well, add 3 times the weight of the medicinal materials in water, soak for 0.5h, decoct twice, each time for 25min, filter to obtain the filtrate, add 10g of butylene glycol and 10g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0072] Embodiment 14

[0073] Weigh 15g of Artemisia capillaris, 13g of Atractylodes lancea, 15g of Angelica dahurica, 11g of Taraxacum mongolicum, 13g of Poria, 15g of Coix seed, 10g of Radix Trichosanthis, 15g of Astragalus, 10g of Cortex Moutan, 8g of Scutellaria baicalensis, 8g of Asarum, 10g of Patchouli, 15g of Lonicera japonica, 11g of Lophatherum gracile, 15g of Angelica sinensis, 11g of Drynaria fortunei, 15g of Morus alba, 11g of Saposhnikovia divaricata, 10g of Crataegus pinnatifida, 11g of Ligusticum chuanxiong and 10g of Platycodon grandiflorum, mix well, add 3 times the weight of the medicinal materials in water, soak for 0.5h, decoct twice, each time for 20min, filter to obtain the filtrate, add 8g of butylene glycol and 8g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0074] Embodiment 15

[0075] Weigh 25g of Artemisia capillaris, 23g of Atractylodes lancea, 25g of Angelica dahurica, 21g of Taraxacum, 23g of Poria, 25g of Coix seed, 20g of Radix Trichosanthis, 25g of Astragalus, 20g of Cortex Moutan, 18g of Scutellaria baicalensis, 18g of Asarum, 20g of Patchouli, 25g of Lonicera japonica, 21g of Lophatherum gracile, 25g of Angelica sinensis, 21g of Drynaria fortunei, 25g of Morus alba, 21g of Saposhnikovia divaricata, 20g of Crataegus pinnatifida, 21g of Ligusticum chuanxiong and 20g of Platycodon grandiflorum, mix well, add 3 times the weight of the medicinal materials in water, soak for 50min, decoct twice, each time for 30min, filter to obtain the filtrate, add 15g of butylene glycol and 15g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0076] Example 16

[0077] Weigh 40g of Artemisia capillaris, 30g of Atractylodes lancea, 70g of Angelica dahurica, 50g of Taraxacum, 70g of Poria, 30g of Coix seed, 20g of Radix Trichosanthis, 40g of Astragalus, 30g of Cortex Moutan, 20g of Scutellaria baicalensis, 10g of Asarum, 20g of Patchouli, 10g of Honeysuckle, 30g of Lophatherum gracile, 30g of Angelica sinensis, 40g of Drynaria fortunei, 20g of Morus alba, 30g of Saposhnikovia divaricata, 20g of Crataegus pinnatifida, 40g of Ligusticum chuanxiong and 20g of Platycodon grandiflorum, mix well, add 4 times the weight of the medicinal materials in water, soak for 0.5h, decoct twice, each time for 20min, filter to obtain the filtrate, add 10g of butylene glycol and 10g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0078] Embodiment 17

[0079] Weigh 12g of Artemisia capillaris, 10g of Atractylodes lancea, 12g of Angelica dahurica, 8g of Taraxacum, 10g of Poria, 12g of Coix seed, 7g of Radix Trichosanthis, 12g of Astragalus, 8g of Cortex Moutan, 5g of Scutellaria baicalensis, 5g of Asarum, 8g of Patchouli, 12g of Lonicera japonica, 8g of Lophatherum gracile, 12g of Angelica sinensis, 8g of Drynaria fortunei, 12g of Morus alba, 8g of Saposhnikovia divaricata, 8g of Crataegus pinnatifida, 8g of Ligusticum chuanxiong and 7g of Platycodon grandiflorum, mix well, add 2 times the weight of the medicinal materials in water, soak for 0.5h, decoct twice, each time for 20min, filter to obtain the filtrate, add 5g of butylene glycol and 5g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0080] Embodiment 18

[0081] Weigh 35g of Artemisia capillaris, 25g of Atractylodes lancea, 60g of Angelica dahurica, 50g of Taraxacum, 60g of Poria, 35g of Coix seed, 25g of Radix Trichosanthis, 45g of Astragalus, 35g of Cortex Moutan, 20g of Scutellaria baicalensis, 10g of Asarum, 20g of Patchouli, 10g of Honeysuckle, 25g of Lophatherum gracile, 20g of Angelica sinensis, 20g of Drynaria fortunei, 15g of Morus alba, 15g of Saposhnikovia divaricata, 10g of Crataegus pinnatifida, 20g of Ligusticum chuanxiong and 30g of Platycodon grandiflorum, mix well, add 4 times the weight of the medicinal materials in water, soak for 1h, decoct twice, 40min each time, filter to obtain the filtrate, add 10g of butylene glycol and 15g of sodium hyaluronate to the filtrate to prepare a pharmaceutical preparation commonly used in pharmacy.

[0082] 1. Clinical efficacy and safety analysis of the composition of the present invention in treating patients with seborrheic alopecia.

[0083] 1 Objects and Methods

[0084] 1.1 Research subjects

[0085] A total of 43 patients with seborrheic alopecia who visited the hospital from September 2023 to May 2024 were selected as the research subjects, including 37 females and 6 males. The youngest was 15 years old and the oldest was 56 years old. The average age was 32.38±8.64 years old. The shortest course of disease was 1 month, the longest course of disease was 10 years, and the average course of disease was 1.47±2.03 years.

[0086] 1.2 Diagnostic criteria

[0087] The diagnostic criteria refer to the relevant diagnostic criteria for AGA in the "Guidelines for the Diagnosis and Treatment of Androgenic Alopecia in Chinese" and the diagnostic criteria for seborrheic alopecia in the "Chinese Journal of Clinical Dermatology":

[0088] ① In the early stage, the hair on the forehead becomes thinner and the hairline gradually moves back;

[0089] ② Oily scalp, itchy scalp, and increased dandruff;

[0090] ③ Skin lesions may be seen on the head, or the head may be bald, or hairless, or with fine hair, or with increased oil content;

[0091] ④ Recently, the patient has noticed significant hair loss.

[0092] 1.3 Inclusion criteria

[0093] Those who meet the above diagnostic criteria and the following conditions: ① Age < 60 years old; ② No relevant treatment for this disease within the previous month; ③ The patient voluntarily signs the informed consent form and cooperates with relevant treatment.

[0094] 1.4 Exclusion criteria

[0095] ① Patients with concurrent scalp tinea capitis, psoriasis, eczema, liver and kidney dysfunction, malignant tumors, and mental illness; ② Patients with immune deficiency alopecia, traumatic alopecia, nutritional alopecia, and drug-induced alopecia;

[0096] ③ Those who are allergic to the experimental drugs;

[0097] ④ Pregnant and lactating women;

[0098] ⑤Patients with skin erosion and exudation.

[0099] 1.5 Falling off and rejection criteria

[0100] ① Those with poor compliance, unable to take medication as required, unable to return for follow-up visits on time, or dropping out midway;

[0101] ② Patients who suddenly develop other diseases during treatment that affect the judgment of efficacy;

[0102] ③ Patients with incomplete clinical data.

[0103] 1.6 Treatment

[0104] 1.6.1 Health education

[0105] Before treatment, patients were given health education and advised to abstain from eating raw, cold, greasy, spicy and irritating foods, maintain a regular work and rest schedule, and try to keep a happy mood.

[0106] 1.6.2 Chinese medicine for external use

[0107] Based on the fundamental pathogenesis of seborrheic alopecia, the method of removing dampness, removing fat and opening the orifices is adopted, that is, the traditional Chinese medicine external preparation, Lingtou hair nourishing liquid, is prepared by using Example 11, and the product quality standard is established by referring to the national standards such as "Chinese Pharmacopoeia", "Cosmetic Safety Technical Specifications", QB / T2660-2004 "Toner", etc., and combining the product characteristics. The method of use is: apply an appropriate amount of this product evenly to the hair loss part, and massage for 5 to 10 minutes. 2 to 4 times a day.

[0108] 1.7 Observation indicators

[0109] 1.7.1 Main symptom score

[0110] According to the "Guidelines for Clinical Research of New Chinese Medicines (Trial)" and the observation indicators formulated by Professor Xuan Guowei, the main symptoms of patients were scored at 0w, 2w, 4w, 6w, and 8w of treatment, including the amount of hair loss, degree of greasiness, itching, and desquamation. The symptom scoring criteria are shown in Table 1.

[0111] Table 1 Main symptom grading and quantification table

[0112]

[0113] 1.7.2 Based on safety evaluation

[0114] Observe whether the included patients have any adverse reactions during medication, such as nausea, vomiting, diarrhea, rash, etc., and evaluate the safety of the medication.

[0115] 1.8 Criteria for determining efficacy

[0116] According to the Guiding Principles for Clinical Research of New Chinese Medicines, the efficacy is divided into four levels: cured, markedly effective, effective, and ineffective. The specific evaluation criteria are shown in Table 2. Total effective rate = (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0117] Table 2 Criteria for judging efficacy

[0118]

[0119] 1.9 Statistical methods

[0120] Graphpad 8.0 statistical software was used for statistical analysis of the data. Paired sample t test was used to compare the data before and after treatment within the same group. P < 0.05 was considered statistically significant.

[0121] 2 Results

[0122] 2.1 Comparison of main symptom scores before and after treatment

[0123] After treatment, the hair loss score, greasiness score, and itching score all decreased significantly compared with those before treatment, with statistical differences (P < 0.05), indicating that Lingtou Hair Growth Essence has a good therapeutic effect. The scale score was generally low and showed a downward trend after treatment, but there was no statistical significance (P > 0.05). See Table 3.

[0124] Table 3 Analysis of efficacy before and after treatment (n=43, )

[0125] time Hair loss score Itch severity score Grease rating Scaly score 0w 5.30±0.95 1.77±1.94 2.70±2.02 0.33±1.05 2w <![CDATA[3.63±1.08 * ]]> <![CDATA[0.93±1.25 * ]]> <![CDATA[1.67±1.43 * ]]> 0.19±0.58 4w <![CDATA[2.56±1.17 * ]]> <![CDATA[0.33±0.74 * ]]> <![CDATA[0.97±1.32 * ]]> 0 6w <![CDATA[1.16±1.08 * ]]> <![CDATA[0.05±0.30 * ]]> <![CDATA[0.33±0.74 * ]]> 0 8w <![CDATA[0.47±1.23 * ]]> <![CDATA[0.09±0.42 * ]]> <![CDATA[0.19±0..72 * ]]> 0

[0126] Note: Compared with 0w, *P<0.05

[0127] 2.2 Comparison of clinical efficacy

[0128] Analysis of efficacy 2 weeks after treatment and 4 weeks after treatment: Compared with 2 weeks after treatment and 4 weeks after treatment, the total effective rate 2 weeks after treatment was 81.4%, and the total effective rate 4 weeks after treatment was 93.0%, P < 0.05, with statistically significant differences, indicating that Lingtou Hair Growth Essence has good therapeutic effects and a good dose-effect relationship.

[0129] Table 4 Comparison of efficacy 4 weeks after treatment and 8 weeks after treatment (n = 43)

[0130]

[0131] Note: Compared with 4 weeks, *P<0.05

[0132] 2.3 Safety evaluation

[0133] During the treatment, no obvious adverse reactions occurred in the included patients, and this treatment method is safe and feasible.

[0134] 2.4 Discussion

[0135] For a long time, there is no Chinese patent medicine specifically for seborrheic alopecia, and there is no corresponding effective, safe and simple health care products and foods. According to preliminary investigation, there are about 14 Chinese patent medicines and 3 external products for treating alopecia on the market. The pathogenesis based on them is not based on dampness as the primary or main pathogenesis, so it does not fully conform to the pathological and physiological characteristics of seborrheic alopecia in modern medicine, nor does it fully conform to the pathogenesis of the disease in traditional Chinese medicine. Therefore, the present invention develops an external product with the effect of removing dampness, removing fat and opening the orifices for the fundamental pathogenesis of dampness, which can directly reach the diseased area, promote blood circulation of the scalp, dredge the meridians, and regulate qi and blood, thereby playing the role of promoting blood circulation and removing blood stasis, removing blood stasis and promoting new hair, and promoting the regeneration of hair.

[0136] 2. Evaluation of clinical efficacy of seborrheic dermatitis

[0137] According to the consensus of Chinese and Western medicine experts on the diagnosis and treatment of seborrheic dermatitis (2024 edition), the following three indicators are mainly used in clinical practice to determine the severity of seborrheic dermatitis. ① Erythema area: score the largest erythema lesion area on the body. 0 points: no erythema; 1 point: erythema area ≤ 2 cm 2 ; 2 points: 2cm 2 <erythema area<5cm 2 ; 3 points: erythema area ≥ 5 cm 2 . ② Scaling severity: The ASFS score (ten-level score for adherent scaling) was used to evaluate the severity of scaling in patients. 0 points: no scaling; 1-2 points: small pieces of powdery grayish-white rough scaling; 3-4 points: small to medium-sized scaling; 5-6 points: large and thin scaling loosely connected to the skin; 7-8 points: large adhesive scaling; 9-10 points: thick white to yellow scaling tightly attached to the skin. ③ Skin itching degree: The degree of skin itching in patients was assessed by the frequency of itching and whether it affected sleep. 0 points: no itching; 1 point: occasional itching; 2 points: frequent itching that does not affect normal sleep; 3 points: frequent itching that affects normal sleep. The total score (a total of 16 points) was obtained by adding up the scores of erythema, scaling, and itching. That is, the "16-point scale" was used to quantify the severity of seborrheic dermatitis. A total score of 0 to 5 indicates mild seborrheic dermatitis, 6 to 9 indicates moderate seborrheic dermatitis, and 10 to 16 indicates severe seborrheic dermatitis. The 16-point scale can more objectively evaluate the severity of seborrheic dermatitis in patients, avoid the influence of subjective factors of different evaluators, guide and standardize the diagnosis and treatment of seborrheic dermatitis, and better evaluate the treatment effect.

[0138] Clinical efficacy evaluation: According to the nimodipine method, the symptom score reduction rate = (pre-treatment score - post-treatment score) / pre-treatment score * 100%. According to the "Chinese Medicine Disease Diagnosis and Efficacy Standards (2017 Edition)", the clinical efficacy determination method is formulated: cure, symptom score reduction ≥ 95%; marked effect, symptom score reduction 70% to <95%; effective, symptom score reduction 30% to <70%; ineffective, symptom score reduction <30%. Clinical total effective rate = cure rate + marked effect rate + effective rate.

[0139] During the treatment, the Chinese medicine prepared by Example 11 was used, and the method of use was: apply an appropriate amount of the product evenly to the affected area of ​​seborrheic dermatitis, and massage for 5 to 10 minutes. 2 to 4 times a day. Comparison of clinical symptom scores before and after treatment The symptom scores of patients after treatment were significantly improved compared with those before treatment, and the comparison of the difference in the symptom scores before and after treatment was statistically significant (P < 0.01), as shown in Table 5.

[0140] Table 5 Comparison of the differences in symptom scores before and after treatment (n=30, )

[0141] Group erythema Scaly Itching 0W 1.65±0.86 3.16±1.67 1.77±0.55 4W <![CDATA[0.48±0.71 * ]]> <![CDATA[0.87±1.36 * ]]> <![CDATA[0.48±0.56 * ]]>

[0142] Note: Compared with 0w, *P<0.01

[0143] Comparison of clinical efficacy after treatment After 4 weeks of treatment, the clinical efficacy was 93.33%. The comparison of clinical efficacy is shown in Table 6. There were no adverse reactions during the treatment.

[0144] Table 6 Comparison of clinical efficacy (%)

[0145] Group n get well Significant effect efficient invalid Efficiency After treatment 30 11(36.67％) 10(33.33％) 7(23.33％) 2(6％) 28(93.33％)

[0146] 3. Evaluation of clinical efficacy of folliculitis

[0147] Clinical efficacy evaluation: cured: the redness and swelling around the hair follicles subside, the skin color returns to normal, there is no tenderness, and the pustules are crusted and fall off; markedly effective: the symptoms are significantly relieved, the redness and swelling range is reduced by ≥70%, the color changes from dark red to light red, the tenderness is significantly relieved, and most of the pustules disappear; effective: the symptoms are alleviated, the redness and swelling range is reduced by 30% to 69%, the color becomes slightly lighter, the tenderness is relieved, and the pustules partially disappear; ineffective: the above standards are not met. Total effective rate = cure rate + markedly effective rate + effective rate.

[0148] During the treatment, the Chinese medicine prepared by Example 11 was used, and the method of use was: apply an appropriate amount of the product evenly to the affected area of ​​folliculitis, and massage for 5 to 10 minutes. 2 to 4 times a day. Comparison of clinical efficacy after treatment After 4 weeks of treatment, the clinical treatment effective rate was 92.00%, and the clinical treatment effective rate was compared, as shown in Table 7. There was no adverse reaction during the treatment.

[0149] Table 7 Comparison of clinical efficacy (%)

[0150] Group n get well Significant effect efficient invalid Efficiency After treatment 25 9(36.00％) 8(32.00％) 6(24.00％) 2(8.00％) 23(92.00％)

[0151] In the description of this specification, specific features, structures, materials or characteristics may be combined in an appropriate manner in any one or more embodiments or examples.

[0152] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A Chinese medicine composition for treating seborrheic alopecia, characterized in that: The invention comprises the following raw materials in parts by weight: 10-60 parts of Artemisia capillaris, 8-50 parts of Atractylodes lancea, 10-90 parts of Angelica dahurica, 6-70 parts of Taraxacum mongolicum, 8-90 parts of Poria cocos, 10-50 parts of Coix seeds, 5-40 parts of Radix Trichosanthis, 10-60 parts of Astragalus, 5-50 parts of Cortex Moutan, 3-40 parts of Scutellaria baicalensis, 3-30 parts of Asarum, 5-40 parts of Patchouli, 10-30 parts of Honeysuckle vine, 6-50 parts of Lophatherum gracile, 10-50 parts of Angelica sinensis, 6-60 parts of Drynaria fortunei, 10-40 parts of Morus alba bark, 6-50 parts of Saposhnikovia divaricata, 5-40 parts of Crataegus pinnatifida, 6-60 parts of Ligusticum chuanxiong and 5-40 parts of Platycodon grandiflorum.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 10-50 parts of Artemisia capillaris, 10-50 parts of Atractylodes lancea, 20-90 parts of Angelica dahurica, 10-70 parts of Taraxacum mongolicum, 10-90 parts of Poria cocos, 10-40 parts of Coix seeds, 8-40 parts of Radix Trichosanthis, 10-50 parts of Astragalus, 10-50 parts of Cortex Moutan, 8-40 parts of Scutellaria baicalensis, 8-30 parts of Asarum, 10-40 parts of Patchouli, 10-25 parts of Honeysuckle vine, 10-50 parts of Lophatherum gracile, 15-50 parts of Angelica sinensis, 10-60 parts of Drynaria fortunei, 15-40 parts of Morus alba bark, 10-50 parts of Saposhnikovia divaricata, 10-40 parts of Crataegus pinnatifida, 10-60 parts of Ligusticum chuanxiong and 8-40 parts of Platycodon grandiflorum.

3. The Chinese medicine composition according to claim 1, characterized in that In parts by weight, the following raw materials are included: 15-50 parts of Artemisia capillaris, 10-40 parts of Atractylodes lancea, 20-70 parts of Angelica dahurica, 20-70 parts of Taraxacum, 20-80 parts of Poria, 10-35 parts of Coix seeds, 10-30 parts of Radix Trichosanthis, 15-60 parts of Astragalus, 20-50 parts of Cortex Moutan, 15-40 parts of Scutellaria baicalensis, 10-30 parts of Asarum, 20-40 parts of Patchouli, 10-20 parts of Honeysuckle vine, 20-50 parts of Lophatherum gracile, 20-50 parts of Angelica sinensis, 20-60 parts of Drynaria fortunei, 20-40 parts of Morus alba bark, 20-50 parts of Saposhnikovia divaricata, 15-40 parts of Charred Crataegus pinnatifida, 20-60 parts of Ligusticum chuanxiong and 10-40 parts of Platycodon grandiflorum.

4. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 20-40 parts of Artemisia capillaris, 20-30 parts of Atractylodes lancea, 40-60 parts of Angelica dahurica, 40-60 parts of Taraxacum mongolicum, 50-80 parts of Poria cocos, 20-30 parts of Coix seeds, 15-30 parts of Radix Trichosanthis, 30-40 parts of Astragalus, 40-50 parts of Cortex Moutan, 20-40 parts of Scutellaria baicalensis, 20-30 parts of Asarum, 30-40 parts of Patchouli, 15-20 parts of Honeysuckle vine, 30-40 parts of Lophatherum gracile, 30-40 parts of Angelica sinensis, 30-40 parts of Drynaria fortunei, 30-40 parts of Morus alba bark, 30-40 parts of Saposhnikovia divaricata, 20-30 parts of Charred Crataegus pinnatifida, 40-50 parts of Ligusticum chuanxiong and 20-30 parts of Platycodon grandiflorum.

5. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 15 parts of Artemisia capillaris, 8 parts of Atractylodes lancea, 12 parts of Angelica dahurica, 20 parts of Taraxacum mongolicum, 15 parts of Poria cocos, 15 parts of Coix seeds, 8 parts of Radix Trichosanthis, 15 parts of Astragalus, 10 parts of Cortex Moutan, 10 parts of Scutellaria baicalensis, 12 parts of Asarum, 15 parts of Patchouli, 20 parts of Honeysuckle Caulis, 30 parts of Lophatherum gracile, 15 parts of Angelica sinensis, 25 parts of Drynaria fortunei, 20 parts of Morus alba bark, 15 parts of Saposhnikovia divaricata, 20 parts of Charred Crataegus pinnatifida, 18 parts of Ligusticum chuanxiong and 8 parts of Platycodon grandiflorum.

6. A method for preparing the Chinese medicine composition according to any one of claims 1 to 5, characterized in that: The steps include: A. Weigh Artemisia capillaris, Atractylodes lancea, Angelica dahurica, Taraxacum mongolicum, Poria cocos, Coix seeds, Radix Trichosanthis, Radix Astragali, Cortex Moutan, Radix Scutellariae, Asarum, Patchouli, Caulis Lonicerae, Folium Lophatherum, Angelica sinensis, Drynariae Rhizoma, Cortex Mori, Saposhnikovia divaricata, Crataegus pinnatifida, Ligusticum chuanxiong and Platycodon grandiflorum by weight, mix well, add 2-4 times of the weight of the medicinal materials in water, soak for 0.5-1h, decoct twice, decoct for 20-40min each time, and filter to obtain a filtrate; B. Adding pharmaceutically acceptable excipients to the filtrate obtained in step A to prepare a pharmaceutical preparation commonly used in pharmacy.

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