Traditional Chinese medicine formula for treating hyperplasia of mammary glands

Abstract

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine formula for treating hyperplasia of mammary glands, which is mainly prepared from the following components: 10-15g of cobra, 10-15g of selfheal, 8-10g of radix clematidis, 10-15g of fructus akebiae, 8-10g of radix curcumae and 8-10g of curcuma zedoary. The cobra, selfheal, radix clematidis, fructus akebiae, radix curcumae and curcuma zedoary are adopted as raw materials, so that the traditional Chinese medicine composition is considerable in curative effect, quick in effect, safe and reliable in long-term administration and free of toxic and side effects.

Description

[Technical field]

[0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine formula for treating breast hyperplasia. [Background technology]

[0002] Cystomegaly is the phenomenon of breast tissue hyperplasia and degeneration, with breast lumps and pain as the two main symptoms. According to the survey, about 70% of women have different degrees of cystomegaly. At present, Western medicine adopts hormone receptor regulation treatment or surgical treatment for cystomegaly, wherein, hormone treatment may cause menstrual disorders or even amenorrhea in patients; surgical treatment leaves scars that affect beauty, and cystomegaly often has the characteristics of multiple and postoperative recurrence, so multiple and repeated operations are required, which brings physical damage and greater psychological impact to patients. And the existing Chinese medicine for the treatment of cystomegaly adopts a large amount of Chinese medicine for breaking blood, promoting qi and resolving phlegm, which is violent and fast, and it is inevitable to hurt the body and is not easy to take for a long time. Therefore, it is urgent to develop a new Chinese medicine prescription for the treatment of cystomegaly, which is of considerable efficacy, quick effect, safe and reliable for long-term use, and has no toxic and side effects, to make up for the above-mentioned defects. [Summary of the invention]

[0003] The technical problem to be solved by the present invention is achieved by adopting the following technical solutions:

[0004] A traditional Chinese medicine prescription for treating breast hyperplasia is mainly prepared from the following components: 10-15 grams of cobra, 10-15 grams of selfheal, 8-10 grams of clematis, 10-15 grams of August sedge, 8-10 grams of turmeric and 8-10 grams of zedoaria.

[0005] Preferably, a Chinese medicine prescription for treating breast hyperplasia is mainly composed of the following components: 15 grams of Naja, 15 grams of Prunella Vulgaris, 10 grams of Clematis, 15 grams of Akebia, 10 grams of Curcuma, and 10 grams of Curcuma.

[0006] Preferably, the Chinese medicine formula for treating breast hyperplasia is prepared into an oral preparation.

[0007] Preferably, the oral preparation of the Chinese medicine formula for treating breast hyperplasia is one of a decoction, an oral liquid, a granule, a tablet, a capsule, and a pill.

[0008] The present invention provides an application of the above-mentioned Chinese medicine formula in preparing a medicine of the Chinese medicine formula for treating breast hyperplasia.

[0009] Preferably, the present invention provides a traditional Chinese medicine preparation for treating breast hyperplasia, which is composed of the above-mentioned traditional Chinese medicine formula and pharmaceutically acceptable excipients.

[0010] Preferably, the dosage form of the Chinese medicine preparation is ointment, granules, pills, powders, tablets, capsules or oral liquid.

[0011] Preferably, the pharmaceutically acceptable excipient is selected from at least one of a solvent, a diluent, a disintegrant, a precipitation inhibitor, a surfactant, a glidant, a binder, a lubricant, a dispersant, a suspending agent, an isotonic agent, a thickener, an emulsifier, a preservative, a stabilizer, a hydrating agent, an emulsification accelerator, a buffer, an absorbent, a colorant, a flavoring agent, a sweetener, an ion exchanger, a release agent, a coating agent, a flavoring agent or an antioxidant.

[0012] The drug mechanism of the drug raw materials used in the present invention is as follows:

[0013] Cobra: Sweet, salty, warm in nature; enters the liver and kidney meridians. Has the effect of dispelling wind, unblocking meridians and relieving pain. Commonly used for rheumatic pain, stroke paralysis, and polio.

[0014] Prunella Vulgaris: pungent, bitter, cold. Enters the liver and gallbladder meridians. Has the effects of clearing the liver and purging fire, improving eyesight, dispersing stagnation and reducing swelling. Can be used for red and swollen eyes, night pain in the eyes, headache and dizziness, scrofula, goiter, breast abscess, breast lumps, and breast pain.

[0015] Clematis: Spicy, salty, warm in nature. Enters the bladder meridian. Has the effect of removing rheumatism and unblocking meridians. Used for rheumatic pain, numbness of limbs, spasm of tendons and veins, and difficulty in flexion and extension.

[0016] August Zha: sweet, cold. Enters the liver, spleen, and kidney meridians. It has the effects of soothing the liver and regulating qi, promoting blood circulation, dispersing blood stasis and relieving pain, and removing restlessness and promoting urination. It is used for liver and stomach qi pain, stomach heat and poor appetite, thirst, low back pain, hypochondria, hernia, menopause, and uterine prolapse.

[0017] Curcuma: pungent, bitter, cold. Enters the liver, heart, and lung meridians. Has the effects of promoting blood circulation and relieving pain, promoting qi and relieving depression, clearing the heart and cooling blood, promoting bile and relieving jaundice. Used for chest and flank pain, chest obstruction and heart pain, amenorrhea and dysmenorrhea, breast pain, febrile coma, epilepsy, vomiting and bleeding due to blood heat, jaundice and red urine.

[0018] Due to the adoption of the above technical scheme, the present invention has the following beneficial effects: the present invention adopts cobra, selfheal, clematis, aconite, turmeric and zedoaria as raw materials, has considerable curative effect, quick effect, is safe and reliable for long-term use, and has no toxic side effects. [Specific implementation method]

[0019] The following embodiments may help those skilled in the art to more fully understand the present invention, but shall not limit the present invention in any way.

[0020] A traditional Chinese medicine prescription for treating breast hyperplasia is mainly prepared from the following components: 10-15 grams of cobra, 10-15 grams of selfheal, 8-10 grams of clematis, 10-15 grams of August sedge, 8-10 grams of turmeric and 8-10 grams of zedoaria.

[0021] Example 1

[0022] A Chinese medicine prescription for treating breast hyperplasia is mainly prepared from the following components: 15 grams of cobra, 15 grams of selfheal, 10 grams of clematis, 15 grams of August sedge, 10 grams of turmeric, and 10 grams of zedoaria.

[0023] A method for preparing a Chinese medicine prescription for treating breast hyperplasia comprises the following steps:

[0024] (1) Preparation: Weigh the ingredients of the formula according to the weight ratio, rinse and dry the cobra, selfheal, clematis, aconite, turmeric, and zedoaria respectively for later use;

[0025] (2) Decoction: Add 3-5 times the amount of water as the raw material, decoct over low heat for 30-40 minutes, filter, and obtain 200-300 ml of filtrate.

[0026] Comparative Example 1

[0027] 15 grams of black-necked snake, 15 grams of selfheal, 10 grams of clematis, 15 grams of atractylodes, 10 grams of turmeric, and 10 grams of curcuma.

[0028] A method for preparing a Chinese medicine formula for treating breast hyperplasia, comprising: (1) preparing: weighing the raw materials of the formula according to the weight ratio, washing and drying the black-striped snake, selfheal, clematis, aconite, turmeric and zedoaria respectively for later use;

[0029] (2) Decoction: add 3-5 times the amount of water as the raw material, decoct over low heat for 30-40 minutes, filter, and obtain 200-300 ml of reference filtrate.

[0030] Experimental example

[0031] The therapeutic effect of the Chinese medicine formula in Example 1 on mammary hyperplasia in SD rats was investigated, as follows:

[0032] 1. Experimental animals: 50 SD rats, female non-pregnant, weighing 180-220g, fed with pellet feed, and entered the experimental period after observation for 1 week. Among them, 10 were injected with physiological saline (0.02mL / kg) once every two days, for a total of 15 times, as a blank group; the remaining 40 were Example 1 group, Comparative Example 1 group, model group and positive control group, and the three groups were injected with estradiol benzoate (0.3mg / kg; Tianjin Jinyao Pharmaceutical Co., Ltd.) and progesterone (4mg / kg; Tianjin Jinyao Pharmaceutical Co., Ltd.) in both thigh muscles every two days, for a total of 15 times, to form a model of mammary hyperplasia.

[0033] 2. Experimental drugs: Take the filtrate prepared in Example 1 and set aside.

[0034] Rupixiao tablets (Liaoning Haohushi Pharmaceutical (Group) Co., Ltd., national medicine standard Z20121823) were crushed and dissolved in water to form a 20 mg / mL solution, which was used as the test drug for rats in the positive control group.

[0035] 3. Experimental process: The rats after modeling were randomly divided into 4 groups (Example 1 group, Comparative Example 1 group, model group and positive control group). The Example 1 group was given the filtrate of Example 1, gavage once a day, 10 mL each time; the Comparative Example 1 group was given the comparison filtrate of Comparative Example 1, gavage once a day, 10 mL each time; the positive control group was given Rupixiao solution, gavage once a day, 10 mL each time; the blank group and the model group were given 10 mL of normal saline, once a day. After continuous gavage for one month, after the last administration, fast for 24 hours, and then measure the rat breast diameter and nipple height with a vernier caliper, the results are shown in Table 1.

[0036] Group Breast diameter (mm) Nipple height (mm) Blank group 1.02±0.13 1.24±0.22 Model Group 1.89±0.12 2.27±0.43 Positive drug group 1.29±0.18 1.86±0.16 Comparative Example 1 1.27±0.42 1.89±0.41 Example 1 Group 1.12±0.17 1.16±0.24

[0037] Table 1 Breast diameter and nipple height of rats in each group

[0038] Table 1 data can be seen, model group and blank group have extremely significant difference, illustrate modeling success. Positive control group compared with model group, breast diameter and nipple height all have significant difference, prove that Rupixiao tablets can effectively improve the breast swelling problem that hyperplasia of mammary glands brings. Embodiment 1 group compared with model group and comparative example 1, breast diameter and nipple height all have significant difference, prove that embodiment of the present invention 1 can also suppress hyperplasia of mammary glands, the effect of embodiment 1 is obviously better than comparative example 1 group simultaneously, effectively improves the breast swelling problem that hyperplasia of mammary glands brings, and the effect is better than positive control group, i.e. Rupixiao tablets.

[0039] At the same time, it can be seen that the therapeutic effect of cobra as a raw material is better than that of garter snake as a raw material. Although garter snake and cobra belong to the same snake family, the effect of garter snake for regulating menstrual disorders is obviously not as good as that of cobra, which shows that not any random snake replacement can achieve the effect that the Chinese medicine prescription for treating breast hyperplasia of the present invention can achieve.

[0040] During the above experiment, no mice in each experimental group died, and after administration, the mice had normal appearance, fur color, luster, social behavior, reaction, feeding and excretion, indicating that the composition of the present invention is safe and reliable.

[0041] Although the present invention has been described in detail above with general descriptions and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements may be made thereto based on the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.

Claims

1. A Chinese medicine formula for treating breast hyperplasia, characterized in that: The invention is mainly made of the following components: 10-15 grams of cobra, 10-15 grams of selfheal, 8-10 grams of clematis, 10-15 grams of August vine, 8-10 grams of turmeric and 8-10 grams of zedoaria.

2. A Chinese medicine prescription for treating breast hyperplasia according to claim 1, characterized in that: It is mainly made of the following ingredients: 15 grams of cobra, 15 grams of selfheal, 10 grams of clematis, 15 grams of August vine, 10 grams of curcuma, and 10 grams of zedoaria.

3. A Chinese medicine prescription for treating breast hyperplasia according to any one of claims 1-2, characterized in that: The Chinese medicine formula for treating breast hyperplasia is prepared into an oral preparation.

4. A Chinese medicine prescription for treating breast hyperplasia according to claim 3, characterized in that The Chinese medicine formula for treating breast hyperplasia, the oral preparation is one of water decoction, oral liquid, granule, tablet, capsule and pill.

5. A method for preparing a Chinese medicine prescription for treating breast hyperplasia according to claim 4, characterized in that: The following steps are involved: (1) Preparation: Weigh the ingredients of the formula according to the weight ratio, rinse and dry the cobra, selfheal, clematis, aconite, turmeric, and zedoaria respectively for later use; (2) Decoction: Add 3-5 times the amount of water as the raw material, decoct over low heat for 30-40 minutes, filter, and obtain 200-300 ml of filtrate.