External traditional Chinese medicine for treating malignant tumor related abdominal distension and application

Abstract

The invention discloses an external traditional Chinese medicine for treating malignant tumor related abdominal distension. Comprising the following raw materials in parts by weight: 300-2500 parts of halite, 5-30 parts of folium artemisiae argyi, 3-30 parts of clove, 6-50 parts of radix angelicae, 3-50 parts of semen brassicae, 3-30 parts of fructus amomi, 5-50 parts of radix aucklandiae, 3-30 parts of semen myristicae, 3-50 parts of semen tsaoko, 5-50 parts of cortex magnoliae officinalis, 3-30 parts of radix et rhizoma rhei, 5-50 parts of rhizoma pinelliae, 5-50 parts of rhizoma cyperi, 5-50 parts of rhizoma corydalis, 5-50 parts of flos rosae rugosae, 3-50 parts of pericarpium zanthoxyli, 5-50 parts of borneol, 5-50 parts of dried ginger, 5-30 parts of mirabilite and 3-50 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition is scientific and reasonable in formula compatibility and convenient to use, has the effects of promoting the circulation of qi, relieving distension, warming the middle warmer, resolving dampness and activating meridians to stop pain, can be effectively used for treating malignant tumor related abdominal distension, is good in effect, is a great innovation of medicines for treating malignant tumor related abdominal distension, and has huge social and economic benefits.

Description

Technical Field

[0001] The invention relates to the field of medicine, in particular to an external Chinese medicine for treating abdominal distension associated with malignant tumors and application thereof. Background Art

[0002] The latest data released by the World Health Organization's International Agency for Research on Cancer (IARC) in 2024 showed that the number of new cancer cases in the world reached 20 million in 2022, including 9.7 million new deaths. It is expected that the number of new cancer cases will surge by 77% in 30 years. The latest data released by the National Cancer Center show that the incidence and mortality of malignant tumors are also showing a continuous upward trend. Abdominal distension is one of the most common accompanying symptoms of cancer patients, often accompanied by symptoms such as poor appetite, nausea and vomiting, pain, and constipation. In the process of clinical treatment, if it is not handled properly, it will lead to complications such as intestinal obstruction, intestinal adhesions, and enterogenic infections, and even death. There are many causes of abdominal distension. Direct factors include adverse reactions of analgesics, local compression of tumors, and adverse effects of anticancer treatment; indirect factors include electrolyte imbalance, long-term bed rest, unreasonable diet, ascites, intestinal adhesion obstruction, etc. It causes poor gastrointestinal function, slow intestinal peristalsis, and abdominal distension. Modern medicine mainly uses gastrointestinal motility drugs, laxatives, enema, anal tube exhaust and other treatment methods. However, for patients with advanced malignant tumors with weak spleen and stomach and deficiency of vital energy, oral medication often increases the gastrointestinal burden of patients, and enema and anal tube exhaust can also cause great pain to patients physically and mentally. Related studies have also shown that Western medicine has limited means of treating abdominal distension and the treatment effect is not ideal.

[0003] "External treatment for internal diseases" is one of the commonly used treatment methods in traditional Chinese medicine. It refers to the use of external therapies (such as hot compresses, plasters, etc.) to act on the body surface to regulate the meridians and blood to achieve the purpose of treating internal diseases. The use of drugs on the surface of the body can prevent the drugs from entering the body directly, reducing the burden and side effects on organs such as the liver and kidneys. So, can we provide an external Chinese medicine to treat abdominal distension related to malignant tumors to solve the problem that existing drugs increase the burden on the patient's gastrointestinal tract (obvious side effects) and have poor effects? However, there have been no relevant public reports so far. Summary of the invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide an external Chinese medicine for treating malignant tumor-related abdominal distension and its application, which can effectively solve the problem that the existing drugs have obvious side effects and poor effects.

[0005] To achieve the above object, the technical solution provided by the present invention is an external Chinese medicine for treating abdominal distension associated with malignant tumors, comprising the following raw materials in parts by weight: 300-2500 parts of daqing salt, 5-30 parts of wormwood leaves, 3-30 parts of cloves, 6-50 parts of angelica dahurica, 3-50 parts of white mustard seeds, 3-30 parts of amomum villosum, 5-50 parts of costusroot, 3-30 parts of nutmeg, 3-50 parts of grass kernels, 5-50 parts of magnolia bark, 3-30 parts of rhubarb, 5-50 parts of pinellia tuber, 5-50 parts of cyperus rotundus, 5-50 parts of corydalis, 5-50 parts of rose, 3-50 parts of prickly ash, 5-50 parts of borneol, 5-50 parts of dried ginger, 5-30 parts of sodium sulfate and 3-50 parts of tangerine peel; wherein, the daqing salt is crushed to obtain particles with a diameter of 2-10 mm; the borneol is crushed to obtain particles with a diameter of 0.5-5 mm particles; after grinding wormwood leaves, rose, clove, angelica dahurica, amomum villosum, costus root, nutmeg, grass fruit kernel, prickly ash, and cyperus rotundus, take particles with a diameter of 0.1-5 mm; after grinding white mustard, magnolia bark, rhubarb, pinellia, yanhusuo, dried ginger, sodium sulfate, and tangerine peel, take particles with a diameter of 0.1-5 mm; mix the above Chinese medicine particles and put them into a cloth bag (size is (10-50 cm) × (5-30 cm) × (1-10 cm)).

[0006] The external Chinese medicine is used in preparing an external medicine for treating abdominal distension associated with malignant tumors.

[0007] The prescription of the invention is scientific and reasonable in composition and compatibility, low in cost, easy to use, has the effects of promoting qi and relieving distension, warming the middle and removing dampness, unblocking meridians and relieving pain, reduces the side effects caused by oral drugs, can be effectively used for treating abdominal distension associated with malignant tumors, has stable and reliable efficacy, and has good effects. It is a major innovation in drugs for treating abdominal distension associated with malignant tumors and has huge social and economic benefits. DETAILED DESCRIPTION

[0008] The specific implementation modes of the present invention are described in detail below in combination with embodiments and specific situations.

[0009] The present invention is specifically implemented by the following examples. Example 1

[0010] A Chinese medicine for external use for treating abdominal distension associated with malignant tumors, comprising the following raw materials in parts by weight: 300 parts of daqing salt, 5 parts of wormwood leaf, 30 parts of clove, 6 parts of angelica root, 50 parts of white mustard seed, 3 parts of amomum villosum, 50 parts of costus root, 3 parts of nutmeg, 50 parts of grass fruit kernel, 5 parts of magnolia bark, 30 parts of rhubarb, 5 parts of pinellia tuber, 50 parts of cyperus rhizome, 5 parts of corydalis, 50 parts of rose, 3 parts of prickly ash, 50 parts of borneol, 5 parts of dried ginger, 30 parts of mirabilite and 3 parts of tangerine peel; wherein the daqing salt is crushed to obtain particles with a diameter of 2-10 mm; the borneol is crushed to obtain particles with a diameter of 0.5-5 mm; the wormwood leaf, rose, clove, angelica root, amomum villosum, costus root, nutmeg, grass fruit kernel, prickly ash and cyperus rhizome are crushed to obtain particles with a diameter of 0.1-5 mm particles; white mustard seeds, Magnolia officinalis, rhubarb, Pinellia, Corydalis, dried ginger, Sodium Sulfate, and dried tangerine peel are crushed to obtain particles with a diameter of 0.1-5 mm; the above Chinese medicine particles are mixed and put into a cloth bag (size of 10×5×2 cm). Example 2

[0011] A Chinese medicine for external use for treating abdominal distension associated with malignant tumors comprises the following raw materials in parts by weight: 2500 parts of isatis salt, 30 parts of wormwood leaves, 3 parts of cloves, 50 parts of angelica dahurica, 3 parts of white mustard seeds, 30 parts of amomum villosum, 5 parts of costusroot, 30 parts of nutmeg, 3 parts of tsaoko seeds, 50 parts of magnolia bark, 3 parts of rhubarb, 50 parts of pinellia tuber, 5 parts of cyperus rotundus, 50 parts of yanhusuo, 5 parts of rose, 50 parts of zanthoxylum bungeanum, 5 parts of borneol, 50 parts of dried ginger, 5 parts of mirabilite and 50 parts of tangerine peel; the specific preparation method is the same as that of Example 1 (the size of the cloth bag is 50×30×10 cm). Example 3

[0012] A Chinese medicine for external use for treating abdominal distension associated with malignant tumors comprises the following raw materials in parts by weight: 1400 parts of isatis salt, 17 parts of wormwood leaves, 12 parts of cloves, 28 parts of angelica dahurica, 26 parts of white mustard seeds, 16 parts of amomum villosum, 27 parts of costusroot, 16 parts of nutmeg, 27 parts of tsaoko seeds, 28 parts of magnolia bark, 16 parts of rhubarb, 27 parts of pinellia tuber, 28 parts of cyperus rotundus, 27 parts of yanhusuo, 27 parts of rose, 26 parts of zanthoxylum bungeanum, 28 parts of borneol, 28 parts of dried ginger, 17 parts of sodium sulfate and 26 parts of dried tangerine peel; the specific preparation method is the same as that in Example 1 (the size of the cloth bag is 30×15×5 cm). Example 4

[0013] A Chinese medicine for external use for treating malignant tumor-related abdominal distension comprises the following raw materials in parts by weight: 800 parts of isatis salt, 10 parts of wormwood leaves, 8 parts of cloves, 20 parts of angelica dahurica, 18 parts of white mustard seeds, 10 parts of amomum villosum, 20 parts of costusroot, 10 parts of nutmeg, 16 parts of tsaoko seeds, 21 parts of magnolia bark, 12 parts of rhubarb, 19 parts of pinellia tuber, 20 parts of cyperus rotundus, 21 parts of yanhusuo, 19 parts of rose, 20 parts of zanthoxylum bungeanum, 22 parts of borneol, 24 parts of dried ginger, 11 parts of sodium sulfate and 23 parts of dried tangerine peel; the specific preparation method is the same as that in Example 1 (the size of the cloth bag is 20×10×5 cm). Example 5

[0014] A Chinese medicine for external use for treating malignant tumor-related abdominal distension comprises the following raw materials in parts by weight: 2100 parts of isatis salt, 25 parts of wormwood leaves, 24 parts of cloves, 40 parts of angelica dahurica, 40 parts of white mustard seeds, 26 parts of amomum villosum, 40 parts of costusroot, 21 parts of nutmeg, 41 parts of tsaoko seeds, 38 parts of magnolia bark, 21 parts of rhubarb, 42 parts of pinellia tuber, 39 parts of cyperus rotundus, 48 ​​parts of yanhusuo, 40 parts of rose, 40 parts of zanthoxylum bungeanum, 45 parts of borneol, 43 parts of dried ginger, 26 parts of sodium sulfate and 35 parts of dried tangerine peel; the specific preparation method is the same as that in Example 1 (the size of the cloth bag is 40×20×10 cm).

[0015] Among the above drugs, Daqingyan salt: salty, cold. Enters the heart, kidney, and bladder meridians. Clears away heat, cools blood, and improves eyesight. Hot compress can improve the body's coldness, warm the meridians and dispel cold, promote menstrual blood discharge, and improve dysmenorrhea symptoms. It can also clear away heat and detoxify, reduce swelling, and promote blood circulation.

[0016] Mugwort leaf: warm in nature, bitter and pungent in taste. It enters the liver meridian, spleen meridian and kidney meridian. Mugwort leaf is pungent, fragrant, bitter, dry, warm and dispersing. Raw is warm and cooked is hot. Stir-fried charcoal is also astringent. Internally, stir-fried charcoal warms the meridians, dispels cold, warms the uterus, astringes and stops bleeding. Raw warms the meridians, dispels cold and dampness, warms the uterus, regulates qi and blood, and stops pain, hemostasis and leukorrhea. External decoction is used for fumigation and washing, drying dampness, killing insects and stopping itching. Moxibustion can warm the meridians, dispel cold and stop pain or swelling.

[0017] Clove: warm in nature, pungent in taste, enters the spleen and stomach meridians, has the effects of warming the middle and dispelling cold, lowering adverse reactions and stopping vomiting. It is often used for symptoms such as spleen and stomach deficiency and cold, hiccups and vomiting, loss of appetite, vomiting and diarrhea, and cold pain in the heart and abdomen.

[0018] Angelica dahurica: pungent, warm. Enters the lung, spleen, and stomach meridians. Indications: dispel wind, dry dampness, reduce swelling, and relieve pain. Treats headaches, supraclavicular pain, toothache, sinusitis, cold and damp abdominal pain, intestinal wind, hemorrhoids, leucorrhea, carbuncle, itchy skin, and scabies.

[0019] White mustard seeds: pungent, warm. Enters the lung meridian. Pungent, dispersing, warming and unblocking, sharp and moving, specifically enters the lung meridian. It warms the lungs, dispels cold phlegm, and promotes the flow of qi, and also dredges the meridians, dispels cold knots, and relieves pain. It has the effects of warming the lungs, dispersing phlegm, promoting qi, dispersing knots, unblocking the meridians and relieving pain. It is used for cough caused by cold phlegm, distending pain in the chest and ribs, phlegm blocking the meridians, numbness and pain in the joints, phlegm-dampness in the flow, and swelling and poison in the yin.

[0020] Amomum villosum: pungent, warm. Enters the spleen, stomach, and kidney meridians. Pungent and dispersing, aromatic and warming, enters the spleen and stomach meridians. It can eliminate dampness and wake up the spleen, promote qi, warm the middle, stop diarrhea, and stabilize the fetus. It is used to treat dampness blocking the middle jiao, spleen and stomach qi stagnation, cold and damp diarrhea, and fetal movement disorders. It is especially suitable for cold and dampness blocking and poor qi movement.

[0021] Muxiang: Spicy, bitter, warm. It enters the spleen, stomach, large intestine, triple energizer, and gallbladder meridians. Muxiang is spicy, warm, and bitter, and can descend. It can ascend or descend. When used raw, it is good at dispersing qi, regulating the middle and relieving pain, helping digestion, appetizing, and strengthening the spleen. When used simmered, it has both activating and stopping effects, and can strengthen the intestines and stop diarrhea. It regulates the triple energizer, is especially good at relieving gastrointestinal qi stagnation, and can also strengthen the spleen and digest food. It is an essential medicine for activating qi, regulating the middle and relieving pain. It is most suitable for people with gastrointestinal qi stagnation with cold or with food accumulation and dampness.

[0022] Nutmeg: pungent and warm in nature. It enters the spleen, stomach, and large intestine meridians. This product is warm and astringent, pungent and fragrant, and dispersing. It is good at warming the middle and astringing the intestines, and treating chronic diarrhea caused by yang deficiency; it can also warm the middle and promote qi circulation, and treat deficiency and cold qi stagnation. It is a product that takes both the symptoms and the root cause into consideration.

[0023] Tsaoko Kernel: warm in nature, pungent in taste, and enters the spleen and stomach meridians. It has the effects of digesting food, eliminating accumulation, relieving cough and reducing phlegm. It can effectively dispel cold and dampness in the body, and has obvious therapeutic effects on symptoms such as spleen and stomach deficiency and cold, vomiting, diarrhea, and cold pain in the abdomen caused by cold and dampness. It also has the effect of promoting qi and relieving pain. For epigastric distension and pain, umbilical and abdominal pain caused by exogenous cold evil, Tsaoko Kernel can warm the middle and dispel cold, promote qi and relieve pain, and effectively relieve the patient's pain.

[0024] Magnolia officinalis: bitter, pungent, warm. Enters the spleen, stomach, lung, and large intestine meridians. Magnolia officinalis is bitter, dry, purgative, pungent, dispersing, warming, and can remove dampness and food accumulation in the gastrointestinal tract, and regulate qi stagnation in the gastrointestinal tract. Therefore, it is an important medicine for treating abdominal distension caused by dampness, food accumulation, and qi stagnation. Enters the lung meridian, can descend qi, remove phlegm and dampness, and relieve asthma. It is commonly used to treat cough, asthma, and excessive phlegm. It has the functions of drying dampness and eliminating phlegm, and removing qi and distension. It is used for dampness stagnation, abdominal distension, vomiting and diarrhea, food accumulation and qi stagnation, abdominal distension and constipation, and phlegm and cough.

[0025] Rhubarb: bitter, cold. Enters the spleen, stomach, and large intestine meridians. Rhubarb is bitter and cold, and it can clear and relieve constipation. It enters the spleen, stomach, and large intestine meridians, as well as the heart, liver meridians, and blood. Internally, it is good at clearing gastrointestinal stagnation and heat, purging heat and relieving constipation, and guiding dampness and heat from the stool, promoting bile and relieving jaundice. Externally, it is good at clearing heat, reducing swelling, relieving pain, detoxifying, and treating sores, carbuncles, and burns.

[0026] Pinellia: pungent, warm; toxic. Enters the spleen, stomach, and lung meridians. Pinellia is pungent, dispersing, warm, and dry. It is toxic but has a strong effect. It enters the spleen, stomach, and lung meridians and is good at removing phlegm and dampness from the spleen and stomach. Internally, it can dry out dampness and resolve phlegm, reduce adverse reactions and stop vomiting, and eliminate lumps and resolve knots. It is an essential medicine for treating phlegm and dampness, cold phlegm, and vomiting. It can be used for all diseases caused by phlegm and dampness. It is most suitable for those with cold symptoms, and bitter and cold products should be used for those with heat symptoms. Externally, it can attack toxins, resolve knots, and reduce swelling. It can treat goiters, phlegm nodules, and carbuncles.

[0027] Cyperus rotundus: pungent, slightly bitter, slightly sweet, neutral. Enters the liver, spleen, and triple burner meridians. Cyperus rotundus is pungent and fragrant, slightly bitter and slightly lowering, slightly sweet and neutral, neutral and not biased. Enters the liver and triple burner meridians, is good at soothing the liver and regulating qi and relieving pain, and is an excellent product for soothing the liver and regulating qi. It was praised by Li Shizhen as "the general director of qi diseases and the commander of gynecology." If the liver qi is smooth and the qi and blood are harmonious, the menstruation will be regulated and the pain can be eliminated, so it is also an important medicine for regulating menstruation and relieving pain.

[0028] Corydalis yanhusuo: pungent, bitter, warm in nature, enters the liver and spleen meridians. This product is pungent, dispersing, bitter, purging, warming and unblocking, and enters the heart, liver and spleen meridians. It promotes blood circulation and qi circulation, and has strong analgesic effect. It can be used for pain caused by blood stasis and qi stagnation, and is better for those with cold.

[0029] Rose: sweet, slightly bitter, warm. Enters the liver and spleen meridians. Has the effects and functions of promoting qi and relieving depression, harmonizing blood, and relieving pain. Used for liver and stomach pain, loss of appetite, nausea, irregular menstruation, and pain from falls.

[0030] Zanthoxylum bungeanum: spicy, warm in nature. Spicy, warm in nature. Warms the middle and relieves pain, kills insects and relieves itching. Used for cold pain in the abdomen, vomiting and diarrhea, abdominal pain caused by insect accumulation; external use: eczema, vaginal itching.

[0031] Borneol: It tastes pungent and bitter, is slightly cold in nature, and enters the heart, liver, and lung meridians. It has the effects of refreshing the mind, dissipating heat and relieving pain, and improving eyesight and removing cataracts. It can assist in the treatment of arthritis, coma, red and swollen eyes, throat paralysis, and mouth sores. It also has an auxiliary therapeutic effect on sores, swelling, sores, and burns caused by water or fire.

[0032] Dried ginger: hot in nature, pungent in taste. It enters the spleen, stomach, heart, and lung meridians, and moves but does not stay. It has the effects of warming the middle and dispelling cold, restoring yang and unblocking meridians, warming the lungs and transforming fluid, and is suitable for the treatment of symptoms such as cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, and cough due to cold fluid.

[0033] Glauber's Salt: Salty, bitter, cold in nature. It enters the stomach and large intestine meridians. Glauber's Salt is bitter, cold, and sinks, and salty can soften hard masses. It enters the stomach, large intestine, and triple burner meridians. Internally, it can purge heat and relieve constipation, moisten and soften dry stool, and accelerate defecation. It is an important medicine for treating internal heat accumulation and hard and difficult to pass dry stool; externally, it can soften and disperse hard lumps, restore milk, and clear heat. It is commonly used to treat sores, swelling, and hemorrhoids. It has similar functions to rhubarb, purging heat and clearing the intestines. It is good at moistening and softening dry stool and lumps. It can not only dilute soft and dry stool, but also promote intestinal peristalsis and purge heat and defecate. It is a bulk laxative with strong heat-clearing and laxative power. It is good at treating constipation caused by internal heat and dryness.

[0034] Tangerine peel: bitter, pungent, warm, enters the lung and spleen meridians. Tangerine peel is pungent and fragrant, bitter, dry and warm, and enters the spleen and lung meridians. It regulates the ascending and descending of the spleen and lung qi and regulates the qi and regulates the middle, and it also dries dampness and regulates qi and resolves phlegm. It can be used for all symptoms of qi stagnation, dampness obstruction, and phlegm congestion. It is especially good for treating qi stagnation in the middle jiao, and is most suitable for those with cold.

[0035] The present invention uses Magnolia officinalis, Aucklandia lappa and Cyperus rotundus as the main drugs, targeting the core pathogenesis of abdominal distension, and leading the promotion of qi and dissipation. Amomum villosum, dried tangerine peel, nutmeg and tsaoko seeds are all ministerial drugs, Amomum villosum can dissipate dampness and stimulate appetite, warm the spleen and stop vomiting, dried tangerine peel can regulate qi and invigorate the spleen, dry dampness and resolve phlegm, nutmeg can warm the middle and promote qi, astringe the intestines and stop diarrhea, and tsaoko seeds can dry dampness and dissipate cold, digest food and resolve accumulation. The four assist the main drugs to enhance the effects of regulating qi and dissipating dampness, warming the middle and invigorating the spleen, and relieve the symptoms of poor appetite, nausea, diarrhea and the like associated with abdominal distension. Dried ginger, Chinese prickly ash, cloves, white mustard seeds, mirabilite, rhubarb, pinellia tuber, corydalis, rose and borneol are all adjuvant drugs, which can promote blood circulation and stop pain, warm the middle and dissipate cold. Daqing salt, mugwort leaf and angelica root harmonize various drugs and serve as guiding drugs. Daqing salt leads drugs into kidney meridians, softens and disperses nodules, mugwort leaf warms meridians and dredges collaterals, penetrates skin and enhances efficacy, and angelica root dispels wind and cold, and carries drugs upward. The three guide the drugs to reach the diseased area and harmonize the direction of action of various drugs. The main, secondary, auxiliary and guiding drugs are scientifically and rationally allocated, and they support and cooperate with each other to achieve the effects of regulating qi and relieving swelling, warming the middle and removing dampness, and clearing the bowels and dispersing nodules.

[0036] As can be seen from the above, the external Chinese medicine for treating malignant tumor-related abdominal distension of the present invention is a Chinese medicine composition mainly for promoting qi and relieving distension, warming the middle and removing dampness, and unblocking meridians and relieving pain, and has the advantages of high efficacy and no toxic side effects. The clinical experiment shows that the efficacy is very good. Taking Example 3 as an example, its clinical data are as follows: 1. Case selection: From February 2020 to February 2025, a total of 380 cases of tumor-related abdominal distension were admitted to the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, including 100 males and 280 females, including 45 cases of colorectal cancer, 56 cases of lung cancer, 37 cases of ovarian cancer, 60 cases of liver cancer, 20 cases of pancreatic cancer, 23 cases of cervical cancer, 68 cases of gastric cancer, 30 cases of breast cancer, 17 cases of esophageal cancer, 15 cases of endometrial cancer, 7 cases of gallbladder cancer, and 2 cases of appendix cancer.

[0037] 2. Treatment plan: The Chinese medicine bag prepared in Example 3 was heated to an internal and external temperature of 50-60° C. using a microwave oven, a thermostat, an oven or other heating equipment, and then placed on the patient's abdomen, back, limb joints, hands, feet, chest or back for 0.3-3 h. Two days constituted one course of treatment, and three courses of treatment were used continuously to statistically evaluate the efficacy.

[0038] 3. Diagnostic criteria: It is formulated with reference to the Gastrointestinal Symptom Rating System (GSRS) and the Guiding Principles for Clinical Research of New Chinese Medicines (Trial Implementation). It includes: The main symptoms are abdominal distension; the secondary symptoms are bowel sounds, flatulence, belching, and poor appetite. The main symptoms are scored from two dimensions: severity and frequency. The specific scoring criteria are as follows: severity: no symptoms, 0 points; symptoms can be felt when idle and quiet, 2 points; symptoms persist but do not affect daily life and work, 4 points; symptoms persist and affect daily life and work, 6 points; frequency of attacks: no, 0 points; 1-2 days / week, 2 points; 3-4 days / week, 4 points; ≥5 days / week, 6 points. The sum of the scores of the two dimensions is the main symptom score.

[0039] Secondary symptoms: mainly scored based on severity, with the specific scoring criteria as follows: 0 points for no symptoms; 1 point for symptoms that can be felt when idle and quiet; 2 points for symptoms that persist but do not affect daily life and work; 3 points for symptoms that persist and affect daily life and work; the evaluation period is 1 week.

[0040] IV. Criteria for determining efficacy: ① Clinical recovery: major symptoms and signs disappear or almost disappear, efficacy index ≥ 95%; ② Significantly effective: major symptoms and signs are significantly improved, 70% ≤ efficacy index <95%; ③ Effective: The main symptoms and signs are significantly improved, with the efficacy index of 30%≤<70%; ④ Ineffective: There is no significant improvement in the main symptoms and signs, or they may even worsen, and the efficacy index is <30%.

[0041] Total effective rate = (clinical cure + marked effect) / total number of cases × 100%.

[0042] 5. Treatment effect: After hot compress according to the treatment plan, according to the efficacy evaluation criteria, after statistical processing, the results are as follows Table 1: Table 1 Efficacy statistics Number of cases cure efficient invalid Total Effectiveness 380 2 337 41 89.2% From the above, we can see that 2 cases were cured (0.5%), 337 cases were effective (88.7%), 41 cases were ineffective (10.8%), and the total effective rate was 89.2%. No toxic side effects were found during the treatment.

[0043] At the same time, while the present invention conducted the above experiments on Example 3, the same clinical experiments were also conducted on Examples 1, 2, 4, and 5, and the same or similar results as those of Example 3 were obtained, which are not listed one by one here, indicating that the present invention has good effects and stable and reliable therapeutic effects.

[0044] 6. Typical Cases Yang Moumou, female, 87 years old, from Fuyang, Anhui. She was diagnosed with gastric cancer for more than one month, with abdominal distension, poor appetite, and belching. The drug of the present invention was used therapeutically, and the symptoms were relieved after one day. After continuous use for 2 weeks, the symptoms were basically relieved.

[0045] 2. Wei, female, 33 years old, from Jining, Shandong. She had ovarian cancer for more than 5 years, intestinal obstruction for more than half a year, abdominal distension, occasional nausea and vomiting, and the symptoms were relieved after continuous use for 1 week.

[0046] 3. Xiao Moumou, female, 62 years old, from Zhengzhou, Henan. Intermittent abdominal pain for more than 3 months, diagnosed with transverse colon cancer for more than 1 month, nausea after eating, vomiting, intermittent abdominal distension and abdominal pain, after continuous use for 1 week, the symptoms were relieved.

[0047] VII. Conclusion In summary, the raw materials of the components of the present invention are abundant and easy to obtain, the compatibility is scientific and reasonable, the cost is low, the effect is good, and the use is convenient. It has the effects of promoting qi and relieving distension, warming the middle and removing dampness, and dredging collaterals to relieve pain. It can directly reach the affected area through transdermal absorption through hot compress, and can effectively relieve the patient's abdominal distension and pain, intestinal rumbling, poor appetite, nausea and vomiting and other symptoms. Compared with oral drugs, it reduces the side effects caused by oral drugs, and at the same time avoids gastrointestinal irritation and liver and kidney metabolic burden. Patient compliance is high, and it can be effectively used to treat malignant tumor-related abdominal distension. The efficacy is stable and reliable, and the effect is good. According to clinical trials, the effective rate is as high as 89.2%. It is a major innovation in drugs for treating malignant tumor-related abdominal distension and has huge social and economic benefits.

[0048] It should be noted that the technical feature and key of the present application is the compatibility of the Chinese medicine composition. The above-mentioned external Chinese medicine hot compress is only an embodiment of a dosage form. All technical schemes that are essentially the same as those of the present application made by equivalent and equivalent replacement means, or various dosage forms suitable for oral administration prepared by conventional preparation methods using the Chinese medicine composition of the present application, all fall within the scope of protection of the present application.

Claims

1. A Chinese medicine for external use for treating abdominal distension associated with malignant tumors, characterized in that: The invention comprises the following raw materials in parts by weight: 300-2500 parts of daqing salt, 5-30 parts of mugwort leaves, 3-30 parts of cloves, 6-50 parts of angelica dahurica, 3-50 parts of white mustard seeds, 3-30 parts of amomum villosum, 5-50 parts of costusroot, 3-30 parts of nutmeg, 3-50 parts of tsaoko seeds, 5-50 parts of magnolia bark, 3-30 parts of rhubarb, 5-50 parts of pinellia tuber, 5-50 parts of cyperus rotundus, 5-50 parts of corydalis, 5-50 parts of rose, 3-50 parts of prickly ash, 5-50 parts of borneol, 5-50 parts of dried ginger, 5-30 parts of mirabilite and 3-50 parts of tangerine peel; wherein, the daqing salt is crushed to obtain a 2-10 mm particles; crush borneol to get particles with a diameter of 0.5-5mm; crush wormwood, rose, clove, angelica dahurica, amomum, costusroot, nutmeg, grass fruit kernel, prickly ash, and cyperus rotundus to get particles with a diameter of 0.1-5mm; crush white mustard, magnolia bark, rhubarb, pinellia, yanhusuo, dried ginger, sodium sulfate, and tangerine peel to get particles with a diameter of 0.1-5mm; mix the above Chinese medicine particles evenly and put them into a cloth bag to obtain the product.

2. The external Chinese medicine for treating malignant tumor-related abdominal distension according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 300 parts of daqing salt, 5 parts of wormwood leaves, 30 parts of cloves, 6 parts of angelica dahurica, 50 parts of white mustard seeds, 3 parts of amomum villosum, 50 parts of costusroot, 3 parts of nutmeg, 50 parts of grass kernels, 5 parts of magnolia bark, 30 parts of rhubarb, 5 parts of pinellia, 50 parts of cyperus rotundus, 5 parts of corydalis, 50 parts of rose, 3 parts of zanthoxylum bungeanum, 50 parts of borneol, 5 parts of dried ginger, 30 parts of sodium sulfate and 3 parts of tangerine peel.

3. The external Chinese medicine for treating malignant tumor-related abdominal distension according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 2500 parts of large blue salt, 30 parts of wormwood leaves, 3 parts of cloves, 50 parts of angelica dahurica, 3 parts of white mustard seeds, 30 parts of amomum villosum, 5 parts of costusroot, 30 parts of nutmeg, 3 parts of grass fruit seeds, 50 parts of magnolia bark, 3 parts of rhubarb, 50 parts of pinellia, 5 parts of cyperus rotundus, 50 parts of corydalis, 5 parts of rose, 50 parts of prickly ash, 5 parts of borneol, 50 parts of dried ginger, 5 parts of sodium sulfate and 50 parts of tangerine peel.

4. The external Chinese medicine for treating malignant tumor-related abdominal distension according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 1400 parts of large blue salt, 17 parts of wormwood leaves, 12 parts of cloves, 28 parts of angelica dahurica, 26 parts of white mustard seeds, 16 parts of amomum villosum, 27 parts of costusroot, 16 parts of nutmeg, 27 parts of tsaoko seeds, 28 parts of magnolia bark, 16 parts of rhubarb, 27 parts of pinellia, 28 parts of cyperus rotundus, 27 parts of yanhusuo, 27 parts of rose, 26 parts of zanthoxylum bungeanum, 28 parts of borneol, 28 parts of dried ginger, 17 parts of sodium sulfate and 26 parts of dried tangerine peel.

5. The external Chinese medicine for treating malignant tumor-related abdominal distension according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 800 parts of daqing salt, 10 parts of wormwood leaves, 8 parts of cloves, 20 parts of angelica dahurica, 18 parts of white mustard seeds, 10 parts of amomum villosum, 20 parts of costusroot, 10 parts of nutmeg, 16 parts of tsaoko seeds, 21 parts of magnolia bark, 12 parts of rhubarb, 19 parts of pinellia tuber, 20 parts of cyperus rotundus, 21 parts of yanhusuo, 19 parts of rose, 20 parts of zanthoxylum bungeanum, 22 parts of borneol, 24 parts of dried ginger, 11 parts of mirabilite and 23 parts of tangerine peel.

6. The external Chinese medicine for treating malignant tumor-related abdominal distension according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 2100 parts of daqin salt, 25 parts of wormwood leaves, 24 parts of cloves, 40 parts of angelica dahurica, 40 parts of white mustard seeds, 26 parts of amomum villosum, 40 parts of costusroot, 21 parts of nutmeg, 41 parts of tsaoko seeds, 38 parts of magnolia bark, 21 parts of rhubarb, 42 parts of pinellia tuber, 39 parts of cyperus rotundus, 48 ​​parts of yanhusuo, 40 parts of rose, 40 parts of zanthoxylum bungeanum, 45 parts of borneol, 43 parts of dried ginger, 26 parts of mirabilite and 35 parts of tangerine peel.

7. Use of the external Chinese medicine according to any one of claims 1 to 6 in the preparation of an external medicine for treating abdominal distension associated with malignant tumors.