Neck, shoulder, waist and leg health-care oil and preparation method thereof

Abstract

The invention discloses neck, shoulder, waist and leg health-care oil and a preparation method thereof, tea-seed oil, sunflower seed oil and bitter almond oil form a nano-carrier, and the nano-carrier is cooperated with 14 active components such as wintergreen oil, camphor and frankincense oil to prepare the neck, shoulder, waist and leg health-care oil through an ultrasonic pretreatment-gradient emulsification-molecular inclusion technology. The product breaks through the traditional oil penetration bottleneck, realizes deep delivery of analgesic and anti-inflammatory components, has dual effects of rapid relief and long-acting repair on neck, shoulder, waist and leg joint pain, and has no skin irritation reaction.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine external preparations, and specifically to a composite plant essential oil composition and a preparation process thereof, which are particularly suitable for alleviating sub-health symptoms such as pain, numbness, soreness and swelling in the neck, shoulder, waist and leg joints. Background Art

[0002] Neck, shoulder, waist and leg pain has become a common disease in modern society. Existing treatments mostly use nonsteroidal anti-inflammatory drugs or plasters, which have risks such as gastrointestinal damage and skin allergies. Traditional Chinese medicine oils generally have problems such as slow onset (such as single safflower oil) and single target. The present invention innovatively combines analgesic, anti-inflammatory, and transdermal penetration-promoting ingredients in a scientific combination to achieve rapid relief of deep tissue pain through multi-pathway synergy. Summary of the invention

[0003] Provide an external preparation with both rapid analgesia and long-lasting repair functions to solve the technical defects of existing products such as insufficient penetration depth and single mechanism of action.

[0004] 1. Raw material composition (by mass percentage): Basic carrier oil (50-65%): Tea seed oil 20-30% Sunflower oil 15-25% Bitter almond oil 10-20% Active essential oil complex (35-50%): Analgesic group: wintergreen oil 4-6%, camphor 3-5%, turpentine 2-4% Blood circulation group: frankincense oil 3-5%, myrrh oil 3-5%, dried ginger oil 2-4% Warming meridian group: cinnamon oil 3-5%, clove oil 2-4%, fennel oil 1-3% Anti-inflammatory group: Litsea cubeba oil 2-4%, Eucalyptus oil 2-4%, Magnolia officinalis oil 1-3% Synergistic group: lavender oil 2-4%, rosemary oil 1-3% 2. Preparation method: a. Base oil pretreatment: Mix tea seed oil, sunflower seed oil and bitter almond oil, and treat with ultrasound (40kHz) at 50-60℃ for 30 minutes b. Gradient fusion of active components: add them in batches in the order of analgesic group → blood circulation group → meridian warming group → anti-inflammatory group → synergistic group, with an interval of 8-12 minutes between each batch c. Dynamic emulsification: During the addition process, maintain a temperature of 55±2℃ and use a high shear emulsifier to stir intermittently at 5000-8000rpm (work 10s / stop 5s) d. Molecular inclusion: Add β-cyclodextrin (0.5-1% of the total mass) and stir with magnetic force at 45°C for 2 hours e. Low temperature aging: Refrigerate at 4-8℃ for 72 hours, then filter and package Beneficial effects: 1. Four-dimensional mechanism of action: Wintergreen oil (methyl salicylate) and camphor form an instant analgesic layer, frankincense-myrrh combination inhibits COX-2 inflammatory factor, cinnamon oil promotes local microcirculation, and β-cyclodextrin inclusion technology prolongs the duration of action 2. Deep penetration system: Ultrasonic treatment makes the base oil particle size ≤50nm, high shear emulsification forms O / W type microemulsion, and the skin penetration rate is increased by 2.3 times compared with traditional oils 3. Clinical verification: 150 patients with cervical and lumbar spondylosis applied the product three times a day for 14 consecutive days. The pain VAS score decreased by 67.8% and the joint range of motion improvement rate reached 81.2%. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 .Process flow chart for preparation of neck, shoulder, waist and leg health oil. DETAILED DESCRIPTION Example

[0005] Raw material ratio (total mass 1000g): Basic carrier oil: 250g tea seed oil, 200g sunflower seed oil, 100g bitter almond oil Active essential oil complex: Analgesic group: 50g wintergreen oil, 40g camphor, 30g turpentine Blood circulation group: frankincense oil 40g, myrrh oil 40g, dried ginger oil 30g Warming meridian group: cinnamon oil 40g, clove oil 30g, fennel oil 20g Anti-inflammatory group: 30g of Litsea cubeba oil, 30g of eucalyptus oil, 20g of magnolia bark oil Synergistic group: lavender oil 30g, rosemary oil 20g Preparation process: 1. After mixing the base oil, ultrasonic treatment was carried out at 55℃ for 30 minutes 2. Add the active ingredient in five batches, with 10 minutes between each batch 3. High shear emulsifier 6000rpm intermittent stirring (10s on / 5s off) 4. Add 8g β-cyclodextrin and stir magnetically at 45℃ for 2 hours 5. Refrigerate and mature at 6℃ for 72 hours, filter through 0.2μm filter membrane and then package Effect test Franz diffusion cell experiments show that: The 6-hour transdermal dose reached 82.4 μg / cm² (1.8 times that of the diclofenac sodium control group) The penetration depth of ex vivo pig skin reached 4.2 mm subcutaneously.

Claims

1. A neck, shoulder, waist and leg health care oil, characterized in that It is composed of the following components in percentage by mass: Basic carrier oil 50-65%: tea seed oil 20-30%, sunflower seed oil 15-25%, bitter almond oil 10-20% Active essential oil complex 35-50%: Analgesic group: wintergreen oil 4-6%, camphor 3-5%, turpentine 2-4% Blood circulation group: frankincense oil 3-5%, myrrh oil 3-5%, dried ginger oil 2-4% Warming meridian group: cinnamon oil 3-5%, clove oil 2-4%, fennel oil 1-3% Anti-inflammatory group: Litsea cubeba oil 2-4%, Eucalyptus oil 2-4%, Magnolia officinalis oil 1-3% Synergistic group: lavender oil 2-4%, rosemary oil 1-3%.

2. The health care oil according to claim 1, characterized in that It also includes a β-cyclodextrin inclusion system, the addition amount of which is 0.5-1% of the total mass.

3. The health care oil according to claim 1, characterized in that The preferred proportion of the active composite essential oil is: 5% wintergreen oil, 4% camphor, 3% turpentine oil, 4% frankincense oil, 4% myrrh oil, 3% dried ginger oil, 4% cinnamon oil, 3% clove oil, 2% fennel oil, 3% litsea cubeba oil, 3% eucalyptus oil, 2% magnolia oil, 3% lavender oil, and 2% rosemary oil.

4. A method for preparing the neck, shoulder, waist and leg health care oil according to any one of claims 1 to 3, characterized in that The following steps are involved: a. Ultrasonic treatment of the base carrier oil to form a nano-scale mixed oil base b. Add active ingredients in the order of analgesia group → blood circulation group → meridian warming group → anti-inflammatory group → synergistic group c. High shear emulsification combined with intermittent stirring to form a microemulsion system d.β-cyclodextrin inclusion treatment e. After low-temperature maturation, filter and package.

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