Targeting o-glcna glycosidase inhibitors to promote remyelination

CN119971037BActive Publication Date: 2026-08-28SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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Patent Information

Application Number
CN202311508656.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-11-13
Publication Date
2026-08-28
Estimated Expiration
2043-11-13

AI Technical Summary

Technical Problem

而目前关于调控OPCs增殖、分化的内在决定因素以及药物治疗的靶点等问题尚不清楚

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Abstract

The present application provides O-GlcNAc glycosidase (O-GlcNAcase, OGA) inhibitors and their applications for promoting remyelination. Specifically, by comparing the promoting effects of different types of OGA inhibitors on OPC differentiation and remyelination in the models of OPC differentiation and remyelination, the OGA inhibitors with drugability of the present application are obtained. The OGA inhibitors of the present application have wide application value in preventing and / or treating demyelination and its related diseases.
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Citation Information

Patent Citations

  • Glycosidase inhibitors

    CN107108601A