Encapsulation layer of probiotics for synergistic tumor chemotherapy, encapsulation method and application

Abstract

The invention discloses a probiotic encapsulation layer for synergistic tumor chemotherapy, an encapsulation method and application, and the encapsulation method comprises the following steps: plant polyphenol and protein are added into to-be-encapsulated probiotics, a first layer is formed on the surface of the probiotics after incubation, and in the first layer, the plant polyphenol and the protein are in non-covalent binding; and dissolving skim milk powder and glucose in a solvent to obtain a second-layer solution, adding the second-layer solution into the probiotics on which the first layer is formed, forming a second layer on the first layer, and forming an encapsulation layer of the probiotics by the first layer and the second layer. According to the invention, an encapsulation layer with a double-layer structure is formed on the surface of the probiotics, so that cytotoxicity and gastric acid invasion caused by chemotherapeutic drugs can be effectively resisted in the probiotic conveying process, biocompatibility and nutritional support are provided for the probiotics, intestinal colonization of the probiotics is promoted, and intestinal flora balance is recovered.

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