Stirring device capable of controlling particle size of liposome adjuvant

Abstract

The invention discloses a stirring device capable of controlling the particle size of a lipidosome adjuvant, and relates to the technical field of lipidosome adjuvant production, the stirring device comprises a bottom plate, the top of the bottom plate is connected with an ultrasonic stirrer, the ultrasonic stirrer comprises a stirring head, the top of the bottom plate is fixedly connected with a supporting plate, and the supporting plate is fixedly connected with the bottom plate. And two groups of electric push rods are symmetrically and fixedly connected to the top of the bottom plate. During use, the arranged electric push rod drives the stirring barrel to move up and down in a reciprocating manner, so that a solution in the stirring barrel can be more uniformly contacted with the stirring head, the liposome is more uniformly mixed with the solution, and the stirring and mixing processing efficiency is improved; when the ultrasonic stirrer is used for stirring and controlling the particle size of the lipidosome, the large lipidosome can be crushed to enable the particle size of the lipidosome to be more uniform, and meanwhile, the lipidosome cannot be damaged, so that the reliability of the stirring device is improved, and the qualified rate of the stirring device is increased.

Description

Technical Field

[0001] The invention relates to the technical field of liposome adjuvant production, in particular to a stirring device capable of controlling the particle size of liposome adjuvant. Background Art

[0002] Adjuvant, also known as immunomodulator or immunopotentiator, is a substance that can non-specifically enhance the body's specific immune response to antigens and play an auxiliary role. Therefore, adjuvant is mainly used as an additive to vaccines. It can induce the body to produce long-term and efficient specific immune response, improve the body's protective ability, and at the same time reduce the amount of immune substances used and reduce the production cost of vaccines.

[0003] Liposome adjuvant is a type of adjuvant. Liposome is a tiny particle composed of lipids that can help encapsulate the effective ingredients of the vaccine and improve the stability and antigen presentation of the vaccine in the body, thereby enhancing the immune response. Therefore, it has been widely used in recent years. When producing liposome adjuvants, the liposomes and the solution need to be mixed and stirred to form a uniform suspension.

[0004] The Chinese invention patent with patent application number CN202120472672.8 records a stirring device with controllable liposome adjuvant particle size, which is provided with a stirring blade. When the stirring blade rotates in the mixer, the fixed bracket connected to the outside of the mixer rotates the mixer through the rotating shaft. Under the action of centrifugal force, the raw materials are fully mixed, the stirring is more sufficient, and the production efficiency is improved. However, in the above-mentioned stirring device, the liposomes and the solution are quickly stirred and mixed by the rotation of the stirring blades and the rotation of the mixer itself. However, since the liposomes are relatively fragile, if the colloid particle size can be controlled during the mechanical stirring process, the colloids with larger particle sizes are broken to make the colloid particle size uniform, more intense mechanical stirring is required to achieve it. Excessively strong mechanical stirring can easily cause damage to the more fragile liposomes, thereby increasing the scrap rate and reducing the reliability and pass rate of the stirring and mixing process. Summary of the invention

[0005] The object of the present invention is to provide a stirring device with controllable liposome adjuvant particle size, so as to solve the problem that the existing liposome adjuvant production stirring device proposed in the above background technology adopts relatively strong mechanical stirring to achieve the mixing of colloid and solution and the control of colloid particle size, which easily leads to damage of liposome and increases the scrap rate, and reduces the reliability and qualified rate of stirring and mixing processing.

[0006] To achieve the above object, the present invention provides the following technical solution: a stirring device for controlling the particle size of liposome adjuvant, comprising a bottom plate, the top of the bottom plate is connected to an ultrasonic stirrer, the ultrasonic stirrer comprises a stirring head, the top of the bottom plate is fixedly connected to a support plate, the top of the bottom plate is symmetrically fixedly connected to two groups of electric push rods, the output ends of the two groups of electric push rods penetrate the support plate and are fixedly connected to a lifting plate, the top of the lifting plate is connected to a stirring barrel;

[0007] The electric push rod pushes the stirring barrel to move up and down through the lifting plate, and then the ultrasonic stirrer is started to stir the solution in the stirring barrel through the stirring head, and the stirring barrel moves up and down so that the stirring head can stir and mix the solution and liposomes in the stirring barrel more fully.

[0008] Preferably, a rotating assembly is provided on the lifting plate, and the stirring barrel is clamped and connected to the rotating assembly through a clamping assembly. The rotating assembly is used to drive the stirring barrel to rotate intermittently, and the axis line of the stirring head is parallel to the axis line of the stirring barrel but not colinear. The advantage of such a setting is that the stirring is more uniform, the fusion speed of the solution and the colloid is accelerated, and the colloid in the solution can be in close contact with the stirring head over a larger range, so that the particle size of the colloid can be controlled to make the particle size of the colloid more uniform.

[0009] Preferably, the rotating assembly includes a driving unit arranged on the lifting plate, the rotating assembly also includes a damping shaft rotatably connected to the center of the top of the lifting plate, the top of the damping shaft is fixedly connected to a rotating plate, the driving unit is used to drive the rotating plate to rotate, the clamping assembly is connected to the top of the rotating plate, and the lifting plate is provided with a fixing unit, and the fixing unit is used to clamp the rotating plate to prevent it from rotating. The advantage of such a setting is that by clamping and fixing the rotating plate with the fixing unit, the mixing barrel can be prevented from moving during the mixing process, thereby ensuring smooth mixing work and improving the reliability of the mixing device.

[0010] Preferably, the driving unit comprises a transmission mechanism and a pushing mechanism which are arranged on the lifting plate, and the pushing mechanism drives the rotating plate to rotate through the transmission mechanism.

[0011] Preferably, the transmission mechanism includes a through cavity opened at the top of the lifting plate, and a first rotating shaft is rotatably connected between the front and rear inner walls of the through cavity, and a ratchet and a large gear are fixedly sleeved on the first rotating shaft from back to front, respectively, and the top of the large gear passes through the top of the through cavity and extends to the upper side of the lifting plate. The transmission mechanism also includes a plurality of driving teeth fixedly connected to the bottom of the rotating plate in a ring shape at equal angles, and the large gear is meshed with the driving teeth. The pushing mechanism is used to push the ratchet to rotate forward or reverse. The advantage of such a configuration is that the large gear is meshed with the plurality of driving teeth, and then cooperates with the damping rotating shaft to stably drive the rotating plate and the mixing barrel to rotate intermittently at equal angles, thereby ensuring that the mixing work is carried out efficiently and reliably.

[0012] Preferably, the pushing mechanism includes a horizontal plate fixedly connected to the left inner wall of the through cavity, two groups of plug rods are symmetrically fixedly connected to the bottom of the horizontal plate, and the bottom ends of the two groups of plug rods are movably sleeved with straight plates, and a first elastic member is fixedly connected between the top of the straight plate and the bottom of the horizontal plate, and a plurality of ratchet teeth are equidistantly connected to the right side of the straight plate from top to bottom, and the plurality of ratchet teeth are meshed with ratchet wheels, and the bottom end of the straight plate passes through the bottom end of the through cavity and extends to the lower side of the lifting plate. The advantage of such an arrangement is that the operation of driving the mixing barrel to rotate intermittently at equal angles can be completed during the reciprocating lifting of the mixing barrel, and no additional power source is required to drive the mixing barrel to rotate, thereby reducing energy consumption and improving the economy and reliability of the mixing device.

[0013] Preferably, a speed control component is provided on the top of the lifting plate, and the speed control component is used to control the rotation speed of the turntable. The advantage of such a setting is that it can control the speed at which the rotation unit drives the turntable to rotate, thereby preventing the lifting plate from falling too fast and causing the turntable to rotate too fast, ensuring that the mixing barrel and the solution inside it can rotate smoothly, thereby ensuring the reliability of the stirring and mixing process.

[0014] Preferably, the speed control component includes a rotating ring rotatably connected to the top of the lifting plate, the top of the rotating ring is fixedly connected to a straight rod, the top of the straight rod is fixedly connected to a square rod, one end of the square rod is connected to a travel switch, and a trigger plate is fixedly connected to the outer circumference of the rotating plate, and the trigger plate can trigger the travel switch. The speed control component also includes a driving motor fixedly connected to the side of the lifting plate, the output end of the driving motor is fixedly connected to a driving wheel, the outer circumference of the driving wheel is tightly against the outer circumference of the rotating ring, and the speed of the driving wheel when driving the rotating ring is less than the speed at which the driving unit drives the rotating plate to rotate. The advantage of such a setting is that as the rotating plate rotates, the trigger plate will be driven to rotate, and the trigger plate will trigger the travel switch. At this time, the driving motor starts and drives the driving wheel to rotate, the driving wheel drives the rotating ring to rotate, and the rotating ring drives the travel switch to rotate. Since the speed of the rotating ring is less than the speed of the rotating plate, the travel switch can offset and reduce the speed of the rotating plate, thereby avoiding the rotating plate from rotating too fast due to the lifting plate descending too fast, ensuring that the mixing barrel and the solution therein can rotate smoothly, and ensuring the reliability of the mixing and mixing process.

[0015] Preferably, the speed control assembly also includes a round rod movably inserted into the end face of the square rod, the end of the round rod away from the square rod is fixedly connected to a rectangular plate, a third elastic member is fixedly connected between the rectangular plate and the end face of the square rod, and the travel switch is fixedly connected to the side of the rectangular plate away from the square rod. The advantage of such an arrangement is that when the trigger plate hits and triggers the travel switch, the round rod cooperates with the third elastic member, the third elastic member can shrink and the travel switch is subjected to excessive force, thereby ensuring the safety of the travel switch and improving the reliability of the stirring device.

[0016] In summary, the technical effects and advantages of the present invention are as follows:

[0017] 1. In the present invention, the electric push rod is provided to drive the stirring barrel to move up and down reciprocatingly, so that the solution in the stirring barrel can contact the stirring head more evenly, so that the liposomes are more evenly mixed with the solution, thereby improving the efficiency of the stirring and mixing process. When the ultrasonic stirrer is used to stir and control the liposome particle size, the larger liposomes can be broken to make the liposome particle size more uniform without causing the liposomes to be destroyed, thereby improving the reliability and qualified rate of the stirring device.

[0018] 2. In the present invention, by setting a rotating component, the stirring barrel can be driven to rotate by the rotating component, thereby increasing the contact range and area between the stirring head and the solution, making the stirring more uniform, accelerating the fusion speed of the solution and the colloid, and allowing the colloid in the solution to be in close contact with the stirring head over a larger range, thereby being able to control the particle size of the colloid to make the particle size of the colloid more uniform. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without paying any creative work.

[0020] Figure 1 This is a schematic structural diagram of a stirring device for controlling the particle size of liposome adjuvants in an embodiment of the present invention;

[0021] Figure 2 This is a schematic diagram of a first partial structure of a stirring device capable of controlling the particle size of liposome adjuvants in an embodiment of the present invention;

[0022] Figure 3 This is a schematic diagram of a second partial structure of a stirring device capable of controlling the particle size of liposome adjuvants in an embodiment of the present invention;

[0023] Figure 4 This is a schematic diagram of a third partial structure of a stirring device capable of controlling the particle size of liposome adjuvants in an embodiment of the present invention;

[0024] Figure 5 This is a schematic diagram of a fourth partial structure of a stirring device capable of controlling the particle size of liposome adjuvants in an embodiment of the present invention;

[0025] Figure 6 It is a schematic cross-sectional structural diagram of a lifting plate in an embodiment of the present invention;

[0026] Figure 7 In the embodiment of the present invention Figure 5 The enlarged schematic diagram of point A in the middle;

[0027] Figure 8 In the embodiment of the present invention Figure 1 A magnified schematic diagram of point B in the middle.

[0028] In the figure: 1, bottom plate; 2, ultrasonic stirrer; 21, stirring head; 3, support plate; 4, electric push rod; 41, lifting plate; 5, stirring barrel; 51, liquid outlet pipe; 6, rotating assembly; 61, driving unit; 611, transmission mechanism; 6111, through cavity; 6112, first rotating shaft; 6113, ratchet; 6114, large gear; 6115, driving tooth; 612, pushing mechanism; 6121, horizontal plate ; 6122, plug rod; 6123, straight plate; 62, damping shaft; 63, rotating plate; 64, fixing unit; 641, rocker rod; 642, clamping plate; 643, toggle member; 7, clamping assembly; 8, speed control assembly; 81, swivel; 82, straight rod; 83, square rod; 84, travel switch; 841, trigger plate; 85, drive motor; 86, drive wheel; 87, round rod; 88, third elastic member. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] Example 1

[0031] Please refer to Figure 1-Figure 8 A stirring device for controlling the particle size of liposome adjuvants shown in the figure comprises a bottom plate 1, an ultrasonic stirrer 2 is connected to the top of the bottom plate 1, the ultrasonic stirrer 2 comprises a stirring head 21, a support plate 3 is fixedly connected to the top of the bottom plate 1, two groups of electric push rods 4 are symmetrically fixedly connected to the top of the bottom plate 1, the output ends of the two groups of electric push rods 4 pass through the support plate 3 and are fixedly connected to a lifting plate 41, a stirring barrel 5 is connected to the top of the lifting plate 41, and a liquid outlet pipe 51 is connected to the outer wall of the stirring barrel 5, so that the liposome solution after stirring is discharged from the stirring barrel 5;

[0032] The electric push rod 4 pushes the stirring barrel 5 to move up and down through the lifting plate 41, and then the ultrasonic stirrer 2 is started and stirs the solution in the stirring barrel 5 through the stirring head 21. The reciprocating movement of the stirring barrel 5 up and down can enable the stirring head 21 to stir and mix the solution and liposomes in the stirring barrel 5 more fully.

[0033] refer to Figure 1-Figure 5 A rotating assembly 6 is provided on the lifting plate 41, and the mixing barrel 5 is clamped and connected to the rotating assembly 6 through a clamping assembly 7. The rotating assembly 6 is used to drive the mixing barrel 5 to rotate intermittently, and the axis line of the mixing head 21 is parallel to the axis line of the mixing barrel 5 but not colinear.

[0034] Specifically, the rotating component 6 can be used to drive the stirring barrel 5 to rotate, thereby increasing the contact range and area between the stirring head 21 and the solution, making the stirring more uniform, accelerating the fusion rate of the solution and the colloid, and allowing the colloid in the solution to be in close contact with the stirring head 21 over a larger range, thereby controlling the particle size of the colloid to make the colloid particle size more uniform.

[0035] refer to Figure 2-Figure 5 The rotating assembly 6 includes a driving unit 61 arranged on the lifting plate 41, and the rotating assembly 6 also includes a damping shaft 62 rotatably connected to the top center of the lifting plate 41. The top of the damping shaft 62 is fixedly connected with a rotating plate 63. The driving unit 61 is used to drive the rotating plate 63 to rotate. The clamping assembly 7 is connected to the top of the rotating plate 63. A fixing unit 64 is provided on the lifting plate 41. The fixing unit 64 is used to clamp the rotating plate 63 to prevent it from rotating.

[0036] Specifically, by clamping and fixing the rotating plate 63 through the fixing unit 64, the stirring barrel 5 can be prevented from moving during the stirring and mixing process, thereby ensuring that the stirring and mixing work proceeds smoothly and improving the reliability of the stirring device;

[0037] The fixing unit 64 includes two swing rods 641 symmetrically connected to the left and right sides of the lifting plate 41 through a first rotating rod and a first torsion spring, and two clamping plates 642 are symmetrically fixedly connected to the top of the two swing rods 641. The sides of the two clamping plates 642 close to each other are concave arc surfaces and can be tightly pressed against the outer side of the rotating plate 63. The fixing unit 64 also includes a toggle member 643 connected to the top of the supporting plate 3. The toggle member 643 is used to drive the two swing rods 641 to swing in opposite directions so that the two clamping plates 642 clamp the rotating plate 63 or move away from the rotating plate 63.

[0038] The toggle member 643 is a top plate fixedly connected to the top of the support plate 3. The top of the top plate is arc-shaped and is tightly against the side of the rocker arm 641 away from the rotating plate 63. The two rocker arms 641 are distributed in an inverted figure eight shape, so that when the lifting plate 41 moves downward, the two top plates can push the top ends of the two rocker arms 641 to rotate in directions away from each other, so that the clamping plate 642 releases the rotating plate 63, thereby ensuring that the rotating component 6 can smoothly drive the rotating plate 63 and the mixing barrel 5 to rotate, so that the clamping and fixing operation of the rotating plate 63 and the rotation of the mixing barrel 5 are orderly and closely combined, and both operations do not require an additional power source, further improving the economy and reliability of the stirring device.

[0039] refer to Figure 2-Figure 4 The driving unit 61 includes a transmission mechanism 611 and a pushing mechanism 612 disposed on the lifting plate 41 . The pushing mechanism 612 drives the rotating plate 63 to rotate through the transmission mechanism 611 .

[0040] refer to Figure 2-Figure 6 The transmission mechanism 611 includes a through cavity 6111 opened at the top of the lifting plate 41, and a first rotating shaft 6112 is rotatably connected between the front and rear inner walls of the through cavity 6111. A ratchet 6113 and a large gear 6114 are fixedly sleeved on the first rotating shaft 6112 from back to front. The top of the large gear 6114 passes through the top of the through cavity 6111 and extends to the upper side of the lifting plate 41. The transmission mechanism 611 also includes a plurality of driving teeth 6115 fixedly connected to the bottom of the rotating plate 63 in an equiangular shape and in a ring shape. The large gear 6114 and the driving teeth 6115 are meshed with each other. The pushing mechanism 612 is used to push the ratchet 6113 to rotate forward or reverse.

[0041] Specifically, by meshing the large gear 6114 with the plurality of driving teeth 6115 and cooperating with the damping shaft 62, the rotating plate 63 and the mixing barrel 5 can be stably driven to intermittently rotate at equal angles, thereby ensuring that the mixing work is carried out efficiently and reliably.

[0042] refer to Figure 2-Figure 6 The pushing mechanism 612 includes a horizontal plate 6121 fixedly connected to the left inner wall of the through cavity 6111, and two groups of plug rods 6122 are symmetrically fixedly connected to the bottom of the horizontal plate 6121, and the bottom ends of the two groups of plug rods 6122 are movably sleeved with a straight plate 6123, and a first elastic member is fixedly connected between the top of the straight plate 6123 and the bottom of the horizontal plate 6121, and a plurality of ratchets are equidistantly connected to the right side of the straight plate 6123 from top to bottom, and the plurality of ratchets are meshed with the ratchet 6113, and the bottom end of the straight plate 6123 passes through the bottom end of the through cavity 6111 and extends to the lower side of the lifting plate 41.

[0043] Specifically, when the straight plate 6123 moves downward to the lowest point as the lifting plate 41 moves downward, the straight plate 6123 will move upward under the obstruction of the support plate 3, so that the straight plate 6123 drives the ratchet to move upward and drives the ratchet 6113 to rotate. When the straight plate 6123 moves downward as the lifting plate 41 moves upward, the ratchet will not drive the ratchet 6113 to rotate. In this way, the operation of driving the mixing barrel 5 to rotate intermittently at equal angles can be completed during the reciprocating lifting and lowering of the mixing barrel 5. No additional power source is needed to drive the mixing barrel 5 to rotate, thereby reducing energy consumption and improving the economy and reliability of the mixing device.

[0044] refer to Figure 1 and Figure 8 A speed control component 8 is provided on the top of the lifting plate 41 , and the speed control component 8 is used to control the rotation speed of the rotating plate 63 .

[0045] Specifically, the speed at which the driving unit 61 drives the rotating plate 63 to rotate can be controlled to prevent the lifting plate 41 from falling too fast and causing the rotating plate 63 to rotate too fast, thereby ensuring that the mixing barrel 5 and the solution therein can rotate smoothly and ensuring the reliability of the mixing process.

[0046] refer to Figure 1 and Figure 8 The speed control component 8 includes a swivel 81 rotatably connected to the top of the lifting plate 41, a straight rod 82 is fixedly connected to the top of the swivel 81, a square rod 83 is fixedly connected to the top of the straight rod 82, a travel switch 84 is connected to one end of the square rod 83, a trigger plate 841 is fixedly connected to the outer circumference of the rotating plate 63, and the trigger plate 841 can trigger the travel switch 84. The speed control component 8 also includes a driving motor 85 fixedly connected to the side of the lifting plate 41, and a driving wheel 86 is fixedly connected to the output end of the driving motor 85. The outer circumference of the driving wheel 86 is tightly against the outer circumference of the swivel 81. The speed of the driving wheel 86 when driving the swivel 81 is less than the speed at which the driving unit 61 drives the rotating plate 63 to rotate.

[0047] Specifically, as the rotating plate 63 rotates, the trigger plate 841 will be driven to rotate, and the trigger plate 841 will trigger the travel switch 84. At this time, the driving motor 85 starts and drives the driving wheel 86 to rotate, the driving wheel 86 drives the rotating ring 81 to rotate, and the rotating ring 81 drives the travel switch 84 to rotate. Since the rotation speed of the rotating ring 81 is lower than the rotation speed of the rotating plate 63, the travel switch 84 can offset and reduce the rotation speed of the rotating plate 63, avoiding the rotating plate 63 from rotating too fast due to the lifting plate 41 descending too fast, ensuring that the mixing barrel 5 and the solution inside it can rotate smoothly, ensuring the reliability of the stirring and mixing process.

[0048] refer to Figure 1 and Figure 8 The speed control assembly 8 also includes a round rod 87 movably inserted into the end surface of the square rod 83, and a rectangular plate is fixedly connected to one end of the round rod 87 away from the square rod 83, and a third elastic member 88 is fixedly connected between the rectangular plate and the end surface of the square rod 83, and a travel switch 84 is fixedly connected to the side of the rectangular plate away from the square rod 83.

[0049] Specifically, by cooperating with the third elastic member 88, when the trigger plate 841 hits and triggers the travel switch 84, the third elastic member 88 can shrink so that the travel switch 84 is subjected to excessive force, thereby ensuring the safety of the travel switch 84 and improving the reliability of the stirring device.

[0050] Finally, it should be noted that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A stirring device for controlling the particle size of liposome adjuvant, comprising a bottom plate (1), characterized in that: The top of the base plate (1) is connected to an ultrasonic stirrer (2), the ultrasonic stirrer (2) comprising a stirring head (21), the top of the base plate (1) is fixedly connected to a support plate (3), the top of the base plate (1) is symmetrically fixedly connected to two groups of electric push rods (4), the output ends of the two groups of electric push rods (4) pass through the support plate (3) and are fixedly connected to a lifting plate (41), and the top of the lifting plate (41) is connected to a stirring barrel (5); The electric push rod (4) pushes the stirring barrel (5) to move up and down reciprocatingly via the lifting plate (41), and then the ultrasonic stirrer (2) is started and the solution in the stirring barrel (5) is stirred via the stirring head (21). The up and down reciprocating movement of the stirring barrel (5) enables the stirring head (21) to stir and mix the solution and liposomes in the stirring barrel (5) more fully.

2. A stirring device for controlling the particle size of liposome adjuvant according to claim 1, characterized in that: The lifting plate (41) is provided with a rotating assembly (6), and the stirring barrel (5) is clamped and connected to the rotating assembly (6) via a clamping assembly (7). The rotating assembly (6) is used to drive the stirring barrel (5) to rotate intermittently, and the axis of the stirring head (21) is parallel to the axis of the stirring barrel (5) but not colinear.

3. A stirring device for controlling the particle size of liposome adjuvant according to claim 2, characterized in that: The rotating assembly (6) comprises a driving unit (61) arranged on the lifting plate (41), and the rotating assembly (6) further comprises a damping shaft (62) rotatably connected to the center of the top of the lifting plate (41), and the top of the damping shaft (62) is fixedly connected to a rotating plate (63), and the driving unit (61) is used to drive the rotating plate (63) to rotate, and the clamping assembly (7) is connected to the top of the rotating plate (63). The lifting plate (41) is provided with a fixing unit (64), and the fixing unit (64) is used to clamp the rotating plate (63) to prevent it from rotating.

4. A stirring device for controlling the particle size of liposome adjuvant according to claim 3, characterized in that: The driving unit (61) comprises a transmission mechanism (611) and a pushing mechanism (612) arranged on the lifting plate (41); the pushing mechanism (612) drives the rotating plate (63) to rotate through the transmission mechanism (611).

5. A stirring device for controlling the particle size of liposome adjuvant according to claim 4, characterized in that: The transmission mechanism (611) includes a through cavity (6111) opened at the top of the lifting plate (41); a first rotating shaft (6112) is rotatably connected between the front and rear inner side walls of the through cavity (6111); a ratchet (6113) and a large gear (6114) are fixedly sleeved on the first rotating shaft (6112) from the back to the front, respectively; the top of the large gear (6114) passes through the top of the through cavity (6111) and extends to the upper side of the lifting plate (41); the transmission mechanism (611) also includes a plurality of driving teeth (6115) fixedly connected to the bottom of the rotating plate (63) in an annular shape at equal angles; the large gear (6114) and the driving teeth (6115) are meshed with each other; and the pushing mechanism (612) is used to push the ratchet (6113) to rotate forward or reverse.

6. A stirring device for controlling the particle size of liposome adjuvant according to claim 5, characterized in that: The pushing mechanism (612) includes a horizontal plate (6121) fixedly connected to the left inner wall of the through cavity (6111), two groups of plug rods (6122) are symmetrically fixedly connected to the bottom of the horizontal plate (6121), and the bottom ends of the two groups of plug rods (6122) are movably sleeved with a straight plate (6123), and a first elastic member is fixedly connected between the top of the straight plate (6123) and the bottom of the horizontal plate (6121), and a plurality of ratchet teeth are equidistantly connected to the right side of the straight plate (6123) from top to bottom, and the plurality of ratchet teeth are meshed with the ratchet wheel (6113), and the bottom end of the straight plate (6123) passes through the bottom end of the through cavity (6111) and extends to the lower side of the lifting plate (41).

7. A stirring device for controlling the particle size of liposome adjuvant according to claim 6, characterized in that: A rotation speed control component (8) is provided on the top of the lifting plate (41), and the rotation speed control component (8) is used to control the rotation speed of the rotating plate (63).

8. A stirring device for controlling the particle size of liposome adjuvant according to claim 7, characterized in that: The speed control component (8) comprises a rotating ring (81) rotatably connected to the top of the lifting plate (41); a straight rod (82) is fixedly connected to the top of the rotating ring (81); a square rod (83) is fixedly connected to the top of the straight rod (82); one end of the square rod (83) is connected to a travel switch (84); a trigger plate (841) is fixedly connected to the outer circumference of the rotating plate (63); the trigger plate (841) can trigger the travel switch (84); the speed control component (88) further comprises a driving motor (85) fixedly connected to the side of the lifting plate (41); a driving wheel (86) is fixedly connected to the output end of the driving motor (85); the outer circumference of the driving wheel (86) is tightly against the outer circumference of the rotating ring (81); the rotation speed of the driving wheel (86) when driving the rotating ring (81) is less than the speed at which the driving unit (61) drives the rotating plate (63) to rotate.

9. A stirring device for controlling the particle size of liposome adjuvant according to claim 8, characterized in that: The speed control assembly (8) further comprises a round rod (87) movably plugged into the end surface of the square rod (83); an end of the round rod (87) away from the square rod (83) is fixedly connected to a rectangular plate; a third elastic member (88) is fixedly connected between the rectangular plate and the end surface of the square rod (83); and the travel switch (84) is fixedly connected to the side surface of the rectangular plate away from the square rod (83).

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