Lateral branch circulation identification method, device and equipment and computer readable storage medium

Abstract

The invention discloses a collateral circulation recognition method, device and equipment and a computer readable storage medium, and the method comprises the steps: obtaining an ischemic penumbra recognized in a target tissue region; acquiring a focus position in the ischemic penumbra, and acquiring at least two stages of angiography images corresponding to the target tissue area; determining blood flow path information in the target tissue area according to the at least two stages of angiography images; according to the blood flow path information, whether a communicated blood flow path exists at the two ends of the focus position or not is determined; if it is determined that the communicated blood flow paths exist at the two ends of the focus position, it is determined that collateral circulation exists. The method can effectively improve the lateral branch circulation recognition rate.

Description

Technical Field

[0001] The present invention relates to the field of computer technology, and in particular to a collateral circulation identification method, device, equipment and computer-readable storage medium. Background Art

[0002] With the development of AI imaging technology, image scanning has become a common auxiliary diagnosis and treatment method in modern medical diagnosis and treatment. Medical imaging can provide doctors with more and more intuitive information about the human body, speeding up doctors' diagnosis of patients' conditions.

[0003] Cerebral infarction is one of the common brain diseases, which is mainly caused by stenosis and blockage of local blood vessels, resulting in cerebral ischemia with insufficient blood supply to the brain. Some cerebral ischemia problems can be alleviated to a certain extent through collateral circulation, thereby avoiding the risk of brain surgery for patients. However, at present, whether there is collateral circulation can only be judged by some examination data and the doctor's experience. It often happens that patients have collateral circulation, but it is not discovered, which leads to deviations in the treatment plan, and even the patient needs to bear the risk of surgery. Summary of the invention

[0004] The embodiments of the present invention provide a collateral circulation identification method, device, equipment and computer-readable storage medium, aiming to effectively improve the imaging effect of medical images.

[0005] In a first aspect, an embodiment of the present invention provides a method for identifying a collateral circulation, wherein the collateral circulation identification comprises:

[0006] Acquiring an ischemic penumbra identified within a target tissue region;

[0007] Acquiring the location of the lesion in the ischemic penumbra, and acquiring at least two phases of angiography images corresponding to the target tissue region;

[0008] Determining blood flow path information in the target tissue region based on the at least two phases of angiography images;

[0009] Determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information;

[0010] If it is determined that there are connected blood flow paths at both ends of the lesion, it is determined that there is collateral circulation.

[0011] Optionally, determining the blood flow path information in the target tissue region according to the at least two phases of angiography images includes:

[0012] obtaining a blood vessel region in each angiographic image;

[0013] The blood flow path information is determined according to the blood vessel region in each angiography image and the acquisition time of each angiography image.

[0014] Optionally, determining the blood flow path information according to the blood vessel region in each angiography image and the acquisition time of each angiography image includes:

[0015] Sequentially stitching the blood vessel regions in each of the angiography images according to the acquisition time of each of the angiography images to obtain a blood vessel path morphology image;

[0016] The blood vessel path morphology image is used as the blood flow path information.

[0017] Optionally, determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information includes:

[0018] Determine a first blood vessel endpoint and a second blood vessel endpoint corresponding to two ends of the lesion position according to the blood vessel path morphology image;

[0019] Determine whether there is a connected blood flow path morphology between the first blood vessel endpoint and the second blood vessel endpoint in the blood vessel path morphology image, so as to determine whether there is a connected blood flow path at both ends of the lesion position.

[0020] Optionally, determining the blood flow path information according to the blood vessel region in each angiography image and the acquisition time of each angiography image includes:

[0021] dividing the target tissue region into a plurality of sub-tissue regions;

[0022] Determine the blood flow sequence of each tissue sub-region according to the blood vessel region in each angiographic image and the acquisition time of each angiographic image;

[0023] The blood flow sequence of each of the sub-tissue regions is set as the blood flow path information.

[0024] Optionally, determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information includes:

[0025] Determine the target sub-tissue region where the lesion is located;

[0026] Determine whether there are other sub-tissue regions with continuous blood flow sequence between the neighboring tissue regions of the target sub-tissue region, so as to determine whether there are connected blood flow paths at both ends of the lesion position.

[0027] Optionally, if it is determined that there are connected blood flow paths at both ends of the lesion, then determining that there is collateral circulation includes:

[0028] If it is determined that there is a connected blood flow path at both ends of the lesion position, obtaining the blood flow path length of the blood flow path;

[0029] If the length of the blood flow path is greater than a length threshold corresponding to the ischemic penumbra, it is determined that collateral circulation exists.

[0030] In a second aspect, an embodiment of the present invention provides a collateral circulation identification device, the collateral circulation identification device comprising:

[0031] An acquisition module, used to acquire an ischemic penumbra identified in a target tissue region, acquire a lesion location in the ischemic penumbra, and acquire at least two phases of angiography images corresponding to the target tissue region;

[0032] A first determination module, configured to determine blood flow path information in the target tissue region according to the at least two phases of angiography images;

[0033] The second determination module is used to determine whether there are connected blood flow paths at both ends of the lesion position according to the blood flow path information; if it is determined that there are connected blood flow paths at both ends of the lesion position, it is determined that there is collateral circulation.

[0034] In a third aspect, an embodiment of the present invention further provides a side branch circulation identification device, comprising a processor and a memory, wherein the memory stores a computer program. When the computer program is executed by the processor, the processor executes the steps of any side branch circulation identification method provided by the embodiment of the present invention.

[0035] In a fourth aspect, an embodiment of the present invention further provides a computer-readable storage medium, the computer-readable storage medium comprising a computer program. When the computer program runs on an electronic device, the computer program is used to enable the electronic device to execute the steps of any side branch circulation identification method provided by an embodiment of the present invention.

[0036] The present invention obtains an ischemic penumbra identified in a target tissue region; obtains a lesion position in the ischemic penumbra, and obtains at least two phases of angiography images corresponding to the target tissue region; determines blood flow path information in the target tissue region based on the at least two phases of angiography images; determines whether there are connected blood flow paths at both ends of the lesion position based on the blood flow path information; if it is determined that there are connected blood flow paths at both ends of the lesion position, then it is determined that there is collateral circulation. In this way, after the ischemic penumbra is found, it can be determined whether there are blood flow paths at both ends of the lesion position of the ischemic penumbra based on the lesion position and the blood flow path information determined from the angiography images corresponding to the target tissue region, so as to determine whether there is collateral circulation, thereby improving the recognition rate of collateral circulation, so that doctors can provide more appropriate treatment plans and reduce the surgical risks of patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0038] Figure 1 It is a flow chart of an embodiment of a collateral circulation identification method provided in an embodiment of the present invention;

[0039] Figure 2 is a schematic diagram of brain collateral circulation provided in an embodiment of the present invention;

[0040] Figure 3 is a schematic diagram of the structure of a collateral circulation identification device provided in an embodiment of the present invention;

[0041] Figure 4 It is a schematic diagram of the structure of a collateral circulation identification device provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention. At the same time, in the description of the embodiments of the present invention, the terms "first", "second", etc. are only used to distinguish the descriptions and cannot be understood as indicating or implying relative importance. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more features. In the description of the embodiments of the present invention, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0043] Embodiments of the present invention provide a collateral circulation identification method, apparatus, device and computer-readable storage medium.

[0044] Specifically, this embodiment will be described from the perspective of a collateral circulation identification device, which can be specifically integrated into a collateral circulation identification device, that is, the collateral circulation identification method of the embodiment of the present invention can be executed by a collateral circulation identification device, and the collateral circulation identification device can be a medical device (such as a magnetic resonance imaging device, etc.), a terminal device (such as a computer, etc.), etc.

[0045] The following is a detailed description in conjunction with the accompanying drawings. In this embodiment, the execution subject is taken as an example of a collateral circulation identification device. It should be noted that the description order of the following embodiments is not intended to limit the preferred order of the embodiments. Although the logical order is shown in the flow chart, in some cases, the steps shown or described may be performed in an order different from that shown in the accompanying drawings.

[0046] According to the background technology of the present invention, some brain ischemia problems can be alleviated to a certain extent through collateral circulation, thereby avoiding the risk of brain surgery for patients. However, at present, whether there is collateral circulation can only be judged by some examination data and the experience of doctors. Often, patients have collateral circulation, but it is not discovered, resulting in deviations in the treatment plan, and even the risk of surgery for patients.

[0047] In order to solve the above problems, the present invention discloses a collateral circulation identification method, please refer to Figure 1 The specific process of the collateral circulation identification method can be as follows: Step S10 to Step S40, wherein:

[0048] Step S10, obtaining the ischemic penumbra identified in the target tissue region;

[0049] In this embodiment, the target tissue region may be a region with blood vessels on the target object, such as the brain region of the target object, and the target object may be an organism with biological characteristics, such as a human body, a pet, etc. The ischemic penumbra in the target tissue region can be identified through medical imaging. The ischemic penumbra refers to a low blood perfusion area around the lesion location. The cells in this area have physiological and biochemical abnormalities and functional disorders due to ischemia, but have not yet died. If the low perfusion condition can be improved in time, these cells can restore normal function; otherwise, they may deteriorate and progress to infarction, thereby aggravating the damage. The medical image can be CT perfusion imaging (CTP) or magnetic resonance perfusion imaging (MRP), etc., and parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP) can be evaluated through medical imaging, thereby helping to identify and define the ischemic penumbra in the target tissue region.

[0050] In one example, some fully automatic software for analyzing cerebral perfusion imaging (CTP), such as rapid, considers Tmax>6s to be an ischemic penumbra. Tmax is the time when the arterial point is found based on CTP. Then deconvolution is performed on the brain tissue area. At this time, for any point in the brain tissue area, if the peak time-arterial point time>6s, the area is considered to be an ischemic penumbra.

[0051] It should be noted that the ischemic penumbra in the target tissue area identified above is not necessarily true, and it is necessary to determine whether there is a corresponding collateral circulation through the collateral circulation identification method provided in this embodiment. If so, the ischemic penumbra is a false ischemic penumbra, and a more conservative treatment plan can be adopted. If not, the ischemic penumbra is a true ischemic penumbra, and the true ischemic penumbra needs to be treated as soon as possible.

[0052] Step S20, obtaining the location of the lesion in the ischemic penumbra, and obtaining at least two phases of angiography images corresponding to the target tissue region;

[0053] In this embodiment, after the ischemic penumbra is identified, the position of the lesion in the ischemic penumbra is further obtained. The position of the lesion belongs to the core area of ​​the ischemic penumbra, and lesions such as infarction may have occurred at the lesion position, and blood flow cannot pass normally here. In some embodiments, the ischemic penumbra may be identified first, and then the position of the lesion in the ischemic penumbra is further identified, or after the ischemic penumbra is identified, the position of the lesion in the ischemic penumbra is determined from a plurality of pre-identified lesion positions. In some embodiments, the position of the lesion in the ischemic penumbra is the cause of the ischemic penumbra.

[0054] In this embodiment, at least two phases of angiography images corresponding to the target tissue region need to be obtained. Each angiography image is an image acquired for the target tissue region and can view the blood vessels in the target tissue region. Different angiography images are images acquired at different times. Due to different acquisition times, different angiography images contain different vascular regions. The order in which blood flows in different vascular regions is consistent with the order in which the angiography images of the vascular regions are acquired.

[0055] In some embodiments, the angiographic image is a medical image acquired at different acquisition times after contrast agent is injected into the target object. The device for scanning medical images can image the contrast agent. When acquiring, the image area corresponding to the area where the contrast agent appears will be brighter, forming a distinct blood vessel area in the medical image. After the contrast agent is injected into the target object, the contrast agent can flow with the blood, so that different imaging effects appear when flowing through different positions. Therefore, the flow of the contrast agent in the blood vessel can be determined through multiple phases of angiographic images, so as to determine the flow of blood and the blood flow path information.

[0056] Step S30, determining blood flow path information in the target tissue region according to the at least two phases of angiography images;

[0057] In this embodiment, since different angiography images contain different vascular regions, the order in which blood flows in different vascular regions is consistent with the acquisition order of the angiography images in which the vascular regions are located. Therefore, according to the vascular regions in each angiography image and the acquisition time of the angiography image, blood path information can be determined to characterize the blood flow in the target tissue region.

[0058] Step S40, determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information;

[0059] In this embodiment, the lesion is located in the target tissue area, and the blood path information is the blood flow condition in the target tissue area. Therefore, based on the blood flow path information, it can be determined whether there are connected blood flow paths at both ends of the ischemic penumbra corresponding to the lesion.

[0060] Step S50: If it is determined that there are connected blood flow paths at both ends of the lesion, it is determined that there is collateral circulation.

[0061] In this embodiment, if there is a connected blood flow path at both ends of the lesion, then the blood has an alternative path to achieve blood circulation, and there is a corresponding collateral circulation. The existence of the collateral circulation causes the blood flow path to become longer, which may cause the blood circulation at the lesion to change, and an ischemic penumbra will be identified; on the contrary, if there is no connected blood flow path at both ends of the lesion, then there is no alternative path to achieve blood circulation, there is no corresponding collateral circulation, and the ischemic penumbra is true. If there is a collateral circulation in the target tissue area, the identified ischemic penumbra can be conservatively treated or the false ischemic penumbra can be left untreated, and the surgical risk of the target object can be reduced by conservative treatment. If there is no collateral circulation in the target tissue area, the ischemic penumbra needs to be treated as soon as possible.

[0062] like Figure 2 As shown in the figure, taking the ischemic penumbra of the brain as an example, the dark dots in the figure are the locations of lesions. Due to the embolism, the brain tissue around the dark dots has ischemia problems, forming an ischemic penumbra. For example, in the light-colored area in the figure, normally, the light-colored area should be supplied with blood through 1→2→3. Now there is embolism at position 3, and the blood supply cannot be met. In this case, if there are connected blood flow paths at both ends of the lesion, that is, 3-2→3'→4→5→6-3, there is collateral circulation, and the original 1→2→3 path can be replaced by the 1→2→3'→4→5→6 path to achieve normal blood supply. However, due to the lengthening of the path, the blood supply speed of the collateral will be slower than the original path, and it will arrive at the original blood supply position a little later, but it will not affect the patient's normal life. A more conservative treatment can be used to treat the ischemic penumbra, which is conducive to the doctor to give an accurate diagnosis plan.

[0063] In the technical solution disclosed in this embodiment, the ischemic penumbra identified in the target tissue region is obtained; the lesion position in the ischemic penumbra is obtained, and at least two phases of angiography images corresponding to the target tissue region are obtained; the blood flow path information in the target tissue region is determined according to the at least two phases of angiography images; according to the blood flow path information, it is determined whether there are connected blood flow paths at both ends of the lesion position; if it is determined that there are connected blood flow paths at both ends of the lesion position, it is determined that there is collateral circulation. In this way, after the ischemic penumbra is found, according to the lesion position and the blood flow path information determined from the angiography images corresponding to the target tissue region, it can be determined whether there are blood flow paths at both ends of the lesion position of the ischemic penumbra, so as to determine whether there is collateral circulation, thereby improving the recognition rate of collateral circulation, so that doctors can give more appropriate treatment plans and reduce the surgical risks of patients.

[0064] In one embodiment, determining the blood flow path information in the target tissue region based on the at least two phases of angiography images includes:

[0065] obtaining a blood vessel region in each angiographic image;

[0066] The blood flow path information is determined according to the blood vessel region in each angiography image and the acquisition time of each angiography image.

[0067] In this embodiment, the blood vessel region corresponding to the contrast agent in the medical image is obtained, and the blood vessel region corresponds to the location of the contrast agent in the target tissue region when the medical image is acquired. The contrast agent flows through the blood vessels, so it can reflect the blood vessel region at that time. These blood vessel regions can be sorted according to the acquisition time corresponding to the medical image, and the flow of the contrast agent in the blood vessel can be restored, thereby quickly and accurately determining the blood flow path information.

[0068] In one embodiment, determining the blood flow path information according to the blood vessel region in each angiography image and the acquisition time of each angiography image includes:

[0069] Sequentially stitching the blood vessel regions in each of the angiography images according to the acquisition time of each of the angiography images to obtain a blood vessel path morphology image;

[0070] The blood vessel path morphology image is used as the blood flow path information.

[0071] In this embodiment, each angiography image may be registered first so that the blood vessel regions in each angiography image correspond to each other, and then the blood vessel regions in each angiography image may be sequentially spliced ​​from the earliest angiography image to the latest angiography image according to the acquisition time of each angiography image, so as to obtain a blood vessel path morphology image. The blood vessel path morphology image can characterize the morphology of blood vessels in the target tissue region, and the blood flow in the target tissue region can be seen in detail from the blood vessel path morphology image, and the blood vessel path morphology image can be used as blood flow path information.

[0072] In one embodiment, determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information includes:

[0073] Determine a first blood vessel endpoint and a second blood vessel endpoint corresponding to two ends of the lesion position according to the blood vessel path morphology image;

[0074] Determine whether there is a connected blood flow path morphology between the first blood vessel endpoint and the second blood vessel endpoint in the blood vessel path morphology image, so as to determine whether there is a connected blood flow path at both ends of the lesion position.

[0075] In this embodiment, determining whether there are connected blood flow paths at both ends of the lesion position according to the blood flow path information includes:

[0076] Determine a first blood vessel endpoint and a second blood vessel endpoint corresponding to two ends of the lesion position according to the blood vessel path morphology image;

[0077] Determine whether there is a connected blood flow path morphology between the first blood vessel endpoint and the second blood vessel endpoint in the blood vessel path morphology image, so as to determine whether there is a connected blood flow path at both ends of the lesion position.

[0078] In this embodiment, by determining the lesion location and the vascular path morphological image, the blood vessel blocked by the lesion location can be determined. In some embodiments, any blood vessel location between the bifurcation point at one end of the blood vessel and the lesion location can be used as the first blood vessel endpoint, and any blood vessel location between the bifurcation point at the other end of the blood vessel and the lesion location can be used as the second blood vessel endpoint.

[0079] In some embodiments, since there is a connecting path between the bifurcation points at both ends of the blood vessel, the first blood vessel endpoint and the second blood vessel endpoint thus set will also be connected, and the bifurcation points at both ends of the blood vessel can be used as the first blood vessel endpoint and the second blood vessel endpoint corresponding to the two ends of the lesion position, respectively, so as to facilitate the determination of the endpoints and improve the calculation efficiency. The first blood vessel endpoint and the second blood vessel endpoint are both points in the blood vessel path image, and then the first blood vessel endpoint is used as the starting point to search along the blood vessels in the blood vessel path morphology image to determine whether there is a blood flow path that can be connected to the second blood vessel endpoint. If so, it is determined that there is a connecting blood flow path at both ends of the lesion position.

[0080] In this way, the blood flow path that accurately connects the two ends of the lesion can be identified, which is suitable for the identification of collaterals of thick blood vessels and further improves the recognition rate of collateral circulation.

[0081] In one embodiment, determining the blood flow path information according to the blood vessel region in each angiography image and the acquisition time of each angiography image includes:

[0082] dividing the target tissue region into a plurality of sub-tissue regions;

[0083] Determine the blood flow sequence of each tissue sub-region according to the blood vessel region in each angiographic image and the acquisition time of each angiographic image;

[0084] The blood flow sequence of each of the sub-tissue regions is set as the blood flow path information.

[0085] In this embodiment, considering that some side branches are very small or relatively complex, it is difficult to determine the specific blood flow path information, and it is impossible to find the connecting path along the blood vessels one by one. Therefore, in this embodiment, there is no need to determine the specific blood flow path morphological image, but the blood flow sequence of the sub-tissue area divided in the target tissue area is set as the blood flow path information to avoid the problem of recognition errors that are easy to occur when the side branches are very small or relatively complex, and to improve the recognition efficiency.

[0086] Specifically, the target tissue area is divided into multiple sub-tissue areas, which will be gradually illuminated due to the flow of contrast agent in the blood as the blood flows through them. Therefore, according to the acquisition time corresponding to each angiography image and the vascular area in each angiography image, the acquisition time when the vascular area first appears in each sub-tissue area is determined, and then according to the acquisition time, the blood flow order of each sub-tissue area is determined, and the blood flow order of each sub-tissue area is set as the blood flow path information.

[0087] In one embodiment, determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information includes:

[0088] Determine the target sub-tissue region where the lesion is located;

[0089] Determine whether there are other sub-tissue regions with continuous blood flow sequence between the neighboring tissue regions of the target sub-tissue region, so as to determine whether there are connected blood flow paths at both ends of the lesion position.

[0090] In this embodiment, the target sub-tissue region where the lesion is located is first determined, and whether there are other sub-tissue regions with continuous blood flow order between the neighboring tissue regions of the target sub-tissue region. The neighboring tissue region is a sub-tissue region adjacent to the target sub-tissue region, and the blood vessels in each sub-tissue region are assimilated into one region, which is equivalent to that if the blood flow order between two sub-tissue regions is continuous, it indicates that there will always be a blood vessel connecting the two sub-tissue regions, but it is impossible to specifically determine which blood vessel it is. Therefore, if there are other sub-tissue regions with continuous blood flow order between the neighboring tissue regions of the target sub-tissue region, it can be determined that there are connected blood flow paths at both ends of the lesion position, otherwise, it cannot be determined that there are connected blood flow paths at both ends of the lesion position.

[0091] In this way, the blood flow sequence of each sub-tissue area is used to determine whether there is a connected blood flow path at both ends of the lesion. There is no need to determine the distribution, flow direction and other information of the blood path. This can avoid the analysis of fine blood vessels, avoid the problem of easy identification errors, and improve the efficiency of identifying collateral circulation.

[0092] In one embodiment, if it is determined that there are connected blood flow paths at both ends of the lesion, then the existence of collateral circulation is determined, including:

[0093] If it is determined that there is a connected blood flow path at both ends of the lesion position, obtaining the blood flow path length of the blood flow path;

[0094] If the length of the blood flow path is greater than a length threshold corresponding to the ischemic penumbra, it is determined that collateral circulation exists.

[0095] In this embodiment, if it is determined that there are connected blood flow paths at both ends of the lesion, the blood flow path length of the blood flow path is obtained, and the blood flow path length can be the specific length of the connected path, or the number of other sub-tissue regions with continuous blood flow order between the neighboring tissue regions of the target sub-tissue region. The blood flow path length can characterize the length of the collateral circulation.

[0096] Specifically, the length of the shortest blood flow path between the first blood vessel endpoint and the second blood vessel endpoint in the blood vessel path morphology image can be used as the blood path length. Because of the existence of collateral circulation, the blood in the ischemic penumbra arrives later than normal. Then, combined with the blood flow path morphology image and the blood flow path length determined above, it can be determined whether the ischemic penumbra is caused by the lengthening of the blood flow path. If the position of the ischemic penumbra is caused by the lengthening of the blood flow path, it can be determined that there is collateral circulation in the target tissue area, otherwise there is no collateral circulation. Specifically, the ischemic area corresponding to the ischemic penumbra is obtained. If the blood flow path information indicates that the blood flow path length is greater than the length threshold corresponding to the ischemic area, that is, the ischemic penumbra corresponds to the blood flow path length, it can be determined that the ischemic penumbra is caused by the lengthening of the blood flow path, so that it can be determined that there is collateral circulation in the target tissue area, otherwise there is no collateral circulation. Thereby further improving the accuracy of collateral circulation identification.

[0097] In some embodiments, determining the ischemic penumbra based on a medical image of the target tissue region includes:

[0098] Acquiring arteriovenous curves of the target tissue area according to the medical image;

[0099] Determine blood flow information in the target tissue region according to the arteriovenous curve, wherein the blood flow information includes at least two of blood flow rate, blood volume and maximum blood flow time;

[0100] The ischemic penumbra of the target tissue area is determined according to the blood flow information.

[0101] In this embodiment, the medical image can obtain the arteriovenous curve of the target tissue area, and the arteriovenous curve can be used to obtain data values ​​such as CBF (blood flow), CBV (blood volume), Tmax (maximum blood flow time) as blood flow information, and the ischemic penumbra of the target tissue area can be quickly identified through these data values. However, the ischemic penumbra in the target tissue area identified in this way is not necessarily true, and it is necessary to determine whether there is a corresponding collateral circulation through the collateral circulation identification method provided in the above embodiment. If there is, the ischemic penumbra is a false ischemic penumbra, and a more conservative treatment plan can be adopted.

[0102] This embodiment also provides a collateral circulation identification device, which can be integrated into a collateral circulation identification device. Figure 3 As shown, the collateral circulation identification device may include:

[0103] An acquisition module 1001 is used to acquire an ischemic penumbra identified in a target tissue region, acquire a lesion location in the ischemic penumbra, and acquire at least two phases of angiography images corresponding to the target tissue region;

[0104] A first determination module 1002 is used to determine the blood flow path information in the target tissue region according to the at least two phases of angiography images;

[0105] The second determination module 1003 is used to determine whether there are connected blood flow paths at both ends of the lesion position according to the blood flow path information; if it is determined that there are connected blood flow paths at both ends of the lesion position, it is determined that there is collateral circulation.

[0106] Optionally, determining the blood flow path information in the target tissue region according to the at least two phases of angiography images includes:

[0107] obtaining a blood vessel region in each angiographic image;

[0108] The blood flow path information is determined according to the blood vessel region in each angiography image and the acquisition time of each angiography image.

[0109] Optionally, determining the blood flow path information according to the blood vessel region in each angiography image and the acquisition time of each angiography image includes:

[0110] Sequentially stitching the blood vessel regions in each of the angiography images according to the acquisition time of each of the angiography images to obtain a blood vessel path morphology image;

[0111] The blood vessel path morphology image is used as the blood flow path information.

[0112] Optionally, determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information includes:

[0113] Determine a first blood vessel endpoint and a second blood vessel endpoint corresponding to two ends of the lesion position according to the blood vessel path morphology image;

[0114] Determine whether there is a connected blood flow path morphology between the first blood vessel endpoint and the second blood vessel endpoint in the blood vessel path morphology image, so as to determine whether there is a connected blood flow path at both ends of the lesion position.

[0115] Optionally, determining the blood flow path information according to the blood vessel region in each angiography image and the acquisition time of each angiography image includes:

[0116] dividing the target tissue region into a plurality of sub-tissue regions;

[0117] Determine the blood flow sequence of each tissue sub-region according to the blood vessel region in each angiographic image and the acquisition time of each angiographic image;

[0118] The blood flow sequence of each of the sub-tissue regions is set as the blood flow path information.

[0119] Optionally, determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information includes:

[0120] Determine the target sub-tissue region where the lesion is located;

[0121] Determine whether there are other sub-tissue regions with continuous blood flow sequence between the neighboring tissue regions of the target sub-tissue region, so as to determine whether there are connected blood flow paths at both ends of the lesion position.

[0122] Optionally, if it is determined that there are connected blood flow paths at both ends of the lesion, then determining that there is collateral circulation includes:

[0123] If it is determined that there is a connected blood flow path at both ends of the lesion position, obtaining the blood flow path length of the blood flow path;

[0124] If the length of the blood flow path is greater than a length threshold corresponding to the ischemic penumbra, it is determined that collateral circulation exists.

[0125] In this embodiment, the ischemic penumbra identified in the target tissue region is obtained; the lesion position in the ischemic penumbra is obtained, and at least two phases of angiography images corresponding to the target tissue region are obtained; the blood flow path information in the target tissue region is determined based on the at least two phases of angiography images; based on the blood flow path information, it is determined whether there are connected blood flow paths at both ends of the lesion position; if it is determined that there are connected blood flow paths at both ends of the lesion position, it is determined that there is collateral circulation. In this way, after the ischemic penumbra is found, based on the lesion position and the blood flow path information determined from the angiography images corresponding to the target tissue region, it can be determined whether there are blood flow paths at both ends of the lesion position of the ischemic penumbra, so as to determine whether there is collateral circulation, thereby improving the recognition rate of collateral circulation, so that doctors can provide more appropriate treatment plans and reduce the surgical risks of patients.

[0126] The specific implementation of the above operations can be found in the previous embodiments, which will not be described in detail here.

[0127] like Figure 4 As shown, Figure 4A schematic diagram of the structure of a collateral circulation identification device provided in an embodiment of the present invention. The collateral circulation identification device 1100 includes a processor 1101 having one or more processing cores, a memory 1102 having one or more computer-readable storage media, and a computer program stored in the memory 1102 and executable on the processor. The processor 1101 is electrically connected to the memory 1102. Those skilled in the art will appreciate that the collateral circulation identification device structure shown in the figure does not constitute a limitation on the collateral circulation identification device, and may include more or fewer components than shown in the figure, or combine certain components, or arrange the components differently.

[0128] The processor 1101 is the control center of the collateral circulation identification device 1100, and uses various interfaces and lines to connect various parts of the entire collateral circulation identification device 1100. By running or loading software programs and / or units stored in the memory 1102, and calling data stored in the memory 1102, the processor 1101 executes various functions of the collateral circulation identification device 1100 and processes data, thereby monitoring the collateral circulation identification device 1100 as a whole. The processor 1101 can be a processor CPU, a graphics processor GPU, a network processor (Network Processor, NP), etc., and can implement or execute the various methods, steps and logic block diagrams disclosed in the embodiments of the present invention.

[0129] In the embodiment of the present invention, the processor 1101 in the side branch loop identification device 1100 will load instructions corresponding to the processes of one or more application programs into the memory 1102 according to the following steps, and the processor 1101 will run the application programs stored in the memory 1102, thereby realizing various functions, such as:

[0130] Acquiring an ischemic penumbra identified within a target tissue region;

[0131] Acquiring the location of the lesion in the ischemic penumbra, and acquiring at least two phases of angiography images corresponding to the target tissue region;

[0132] Determining blood flow path information in the target tissue region based on the at least two phases of angiography images;

[0133] Determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information;

[0134] If it is determined that there are connected blood flow paths at both ends of the lesion, it is determined that there is collateral circulation.

[0135] The specific implementation of the above operations can be found in the previous embodiments, which will not be described in detail here.

[0136] Optional, such as Figure 4 As shown, the collateral circulation identification device 1100 also includes: a touch screen 1103, a radio frequency circuit 1104, an audio circuit 1105, an input unit 1106 and a power supply 1107. Among them, the processor 1101 is electrically connected to the touch screen 1103, the radio frequency circuit 1104, the audio circuit 1105, the input unit 1106 and the power supply 1107 respectively. Those skilled in the art can understand that Figure 4 The collateral circulation identification device structure shown in the figure does not constitute a limitation on the collateral circulation identification device, and may include more or less components than shown in the figure, or combine certain components, or arrange the components differently.

[0137] The touch display screen 1103 can be used for displaying a graphical user interface and receiving an operation instruction generated by the user acting on the graphical user interface. The touch display screen 1103 can include a display panel and a touch panel. Wherein, the display panel can be used for displaying information input by a user or information provided to a user and various graphical user interfaces of a collateral circulation identification device, and these graphical user interfaces can be composed of graphics, text, icons, videos and any combination thereof. Optionally, a liquid crystal display (LCD, Liquid Crystal Display), an organic light emitting diode (OLED, Organic Light-EmittingDiode) and other forms can be used to configure the display panel. The touch panel can be used for collecting the touch operation of the user thereon or near it (such as the user uses any suitable object or attachment such as a finger, a stylus on the touch panel or near the touch panel), and generates corresponding operation instructions, and the operation instructions execute corresponding programs. Optionally, the touch panel may include two parts of a touch detection device and a touch controller. Among them, the touch detection device detects the user's touch orientation, detects the signal brought by the touch operation, and transmits the signal to the touch controller; the touch controller receives the touch information from the touch detection device, converts it into the touch point coordinates, and then sends it to the processor 1101, and can receive the command sent by the processor 1101 and execute it. The touch panel can cover the display panel. When the touch panel detects a touch operation on or near it, it is transmitted to the processor 1101 to determine the type of touch event, and then the processor 1101 provides corresponding visual output on the display panel according to the type of touch event. In an embodiment of the present invention, the touch panel and the display panel can be integrated into the touch display screen 1103 to realize the input and output functions. However, in some embodiments, the touch panel and the touch panel can be used as two independent components to realize the input and output functions. That is, the touch display screen 1103 can also be used as a part of the input unit 1106 to realize the input function.

[0138] The radio frequency circuit 1104 may be used to send and receive radio frequency signals, so as to establish wireless communication with a network device or other collateral circulation identification devices through wireless communication, and to send and receive signals between the network device or other collateral circulation identification devices.

[0139] The audio circuit 1105 can be used to provide an audio interface between the user and the collateral circulation identification device through a speaker and a microphone. The audio circuit 1105 can transmit the electrical signal converted from the received audio data to the speaker, which is converted into a sound signal for output; on the other hand, the microphone converts the collected sound signal into an electrical signal, which is received by the audio circuit 1105 and converted into audio data, and then the audio data is output to the processor 1101 for processing, and then sent to another collateral circulation identification device through the radio frequency circuit 1104, or the audio data is output to the memory 1102 for further processing. The audio circuit 1105 may also include an earplug jack to provide communication between an external earphone and the collateral circulation identification device.

[0140] The input unit 1106 may be used to receive input numbers, character information or user feature information (such as fingerprint, iris, facial information, etc.), and generate keyboard, mouse, joystick, optical or trackball signal input related to user settings and function control.

[0141] The power supply 1107 is used to supply power to various components of the collateral circulation identification device 1100. Optionally, the power supply 1107 can be logically connected to the processor 1101 through a power management system, so as to manage charging, discharging, and power consumption management through the power management system. The power supply 1107 can also include one or more DC or AC power supplies, recharging systems, power failure detection circuits, power converters or inverters, power status indicators, and other arbitrary components.

[0142] although Figure 4 Not shown in the figure, the collateral circulation identification device 1100 may also include a camera, a sensor, a wireless fidelity module, a Bluetooth module, etc., which will not be repeated here.

[0143] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0144] A person of ordinary skill in the art will appreciate that all or part of the steps in the various methods of the above embodiments may be completed by instructions, or by controlling related hardware through instructions. The instructions may be stored in a computer-readable storage medium and loaded and executed by a processor.

[0145] To this end, an embodiment of the present invention provides a computer-readable storage medium, in which a plurality of computer programs are stored, and the computer program can be loaded by a processor to execute any of the collateral circulation identification methods provided in the embodiments of the present invention. The computer program can execute the following steps of the collateral circulation identification method:

[0146] Acquiring an ischemic penumbra identified within a target tissue region;

[0147] Acquiring the location of the lesion in the ischemic penumbra, and acquiring at least two phases of angiography images corresponding to the target tissue region;

[0148] Determining blood flow path information in the target tissue region based on the at least two phases of angiography images;

[0149] Determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information;

[0150] If it is determined that there are connected blood flow paths at both ends of the lesion, it is determined that there is collateral circulation.

[0151] The specific implementation of the above operations can be found in the previous embodiments, which will not be described in detail here.

[0152] The computer-readable storage medium may include: a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk, etc.

[0153] Since the computer program stored in the computer-readable storage medium can execute any of the side branch circulation identification methods provided in the embodiments of the present invention, the beneficial effects that can be achieved by any of the side branch circulation identification methods provided in the embodiments of the present invention can be achieved. Please refer to the previous embodiments for details and will not be repeated here.

[0154] In the above-mentioned collateral circulation identification device, computer-readable storage medium, collateral circulation identification equipment, and computer program product embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments. Those skilled in the art can clearly understand that for the convenience and simplicity of description, the specific working process and beneficial effects of the collateral circulation identification device, computer-readable storage medium, computer program product, collateral circulation identification device and its corresponding units described above can refer to the description of the collateral circulation identification method in the above embodiment, and will not be repeated here.

[0155] The above is a detailed introduction to a collateral circulation identification method, a collateral circulation identification device, a collateral circulation identification equipment, a computer-readable storage medium and a computer program product provided in an embodiment of the present invention. Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea; at the same time, for technical personnel in this field, according to the idea of ​​the present invention, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present invention.

Claims

1. A method for identifying collateral circulation, characterized in that: The collateral circulation identification comprises: Acquiring an ischemic penumbra identified within a target tissue region; Acquiring the location of the lesion in the ischemic penumbra, and acquiring at least two phases of angiography images corresponding to the target tissue region; Determining blood flow path information in the target tissue region based on the at least two phases of angiography images; Determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information; If it is determined that there are connected blood flow paths at both ends of the lesion, it is determined that there is collateral circulation.

2. The collateral circulation identification method according to claim 1, characterized in that: The determining of the blood flow path information in the target tissue region according to the at least two phases of angiography images comprises: obtaining a blood vessel region in each angiographic image; The blood flow path information is determined according to the blood vessel region in each angiography image and the acquisition time of each angiography image.

3. The collateral circulation identification method according to claim 2, characterized in that: Determining the blood flow path information according to the blood vessel region in each angiography image and the acquisition time of each angiography image includes: Sequentially stitching the blood vessel regions in each of the angiography images according to the acquisition time of each of the angiography images to obtain a blood vessel path morphology image; The blood vessel path morphology image is used as the blood flow path information.

4. The collateral circulation identification method according to claim 3, characterized in that: Determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information includes: Determine a first blood vessel endpoint and a second blood vessel endpoint corresponding to two ends of the lesion position according to the blood vessel path morphology image; Determine whether there is a connected blood flow path morphology between the first blood vessel endpoint and the second blood vessel endpoint in the blood vessel path morphology image, so as to determine whether there is a connected blood flow path at both ends of the lesion position.

5. The collateral circulation identification method according to claim 2, characterized in that: Determining the blood flow path information according to the blood vessel region in each angiography image and the acquisition time of each angiography image includes: dividing the target tissue region into a plurality of sub-tissue regions; Determine the blood flow sequence of each tissue sub-region according to the blood vessel region in each angiographic image and the acquisition time of each angiographic image; The blood flow sequence of each of the sub-tissue regions is set as the blood flow path information.

6. The collateral circulation identification method according to claim 5, characterized in that: Determining whether there are connected blood flow paths at both ends of the lesion location according to the blood flow path information includes: Determine the target sub-tissue region where the lesion is located; Determine whether there are other sub-tissue regions with continuous blood flow sequence between the neighboring tissue regions of the target sub-tissue region, so as to determine whether there are connected blood flow paths at both ends of the lesion position.

7. The collateral circulation identification method according to claim 1, characterized in that: If it is determined that there are connected blood flow paths at both ends of the lesion, then it is determined that there is collateral circulation, including: If it is determined that there is a connected blood flow path at both ends of the lesion position, obtaining the blood flow path length of the blood flow path; If the length of the blood flow path is greater than a length threshold corresponding to the ischemic penumbra, it is determined that collateral circulation exists.

8. A collateral circulation identification device, characterized in that: The collateral circulation identification device comprises: An acquisition module, used to acquire an ischemic penumbra identified in a target tissue region, acquire a lesion location in the ischemic penumbra, and acquire at least two phases of angiography images corresponding to the target tissue region; A first determination module, configured to determine blood flow path information in the target tissue region according to the at least two phases of angiography images; The second determination module is used to determine whether there are connected blood flow paths at both ends of the lesion position according to the blood flow path information; if it is determined that there are connected blood flow paths at both ends of the lesion position, it is determined that there is collateral circulation.

9. A collateral circulation identification device, characterized in that: The invention comprises a processor and a memory, wherein the memory stores a computer program, and when the computer program is executed by the processor, the processor executes the steps of the side branch circulation identification method according to any one of claims 1 to 7.

10. A computer-readable storage medium, characterized in that: The computer-readable storage medium comprises a computer program. When the computer program is executed on an electronic device, the computer program is used to enable the electronic device to execute the steps of the collateral circulation identification method according to any one of claims 1 to 7.

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