Traditional Chinese medicine composition for treating pain, traditional Chinese medicine patch and preparation method of traditional Chinese medicine patch

Abstract

The invention discloses a traditional Chinese medicine composition for treating pain, a traditional Chinese medicine patch and a preparation method of the traditional Chinese medicine patch. The traditional Chinese medicine patch comprises a pasty ointment, and oil paper is covered with the pasty ointment; the pasty ointment comprises the following components in parts by weight: 4-6 parts of a traditional Chinese medicine composition, 3-5 parts of honey and 0.5-2 parts of an auxiliary matrix; the traditional Chinese medicine composition is prepared from vinegar-processed rhizoma corydalis, vinegar-processed szechwan chinaberry fruit, vinegar-processed trogopterus dung, vinegar-processed frankincense and vinegar-processed myrrh, and the prepared preparation is low in cost, high in production efficiency and better in cancer pain relieving effect compared with similar products.

Description

Technical Field

[0001] The invention relates to the field of medicament production, and in particular to a traditional Chinese medicine composition for treating pain, a traditional Chinese medicine patch and a preparation method thereof. Background Art

[0002] Pain caused by tumors is one of the most common and painful symptoms for patients in the middle and late stages of the disease. It is an important factor affecting the quality of life of cancer patients. Because the causes of cancer pain are very complex, the treatment of cancer pain has always troubled clinicians.

[0003] At present, the drugs for treating tumor pain at home and abroad mainly include three categories: non-opioid analgesics (such as aspirin), opium analgesics and auxiliary analgesics (such as diazepam, etc.). Chinese medicine preparations have also been studied in cancer analgesia. For example, application number: CN200810167612.4 proposes a nano-drug magnetic patch for tumor detumescence and analgesia. Each Chinese medicine powder is mixed with ethanol, concentrated to a thick paste by ethanol percolation, and azone and nano far-infrared ceramic powder are added to obtain a fluid extract. The fluid extract is pressed on a transdermal skeleton with a neodymium iron boron magnet to obtain a plaster. The plaster has the advantages of low cost, certain efficacy and no toxic side effects. However, the types of raw materials and the production method required for the preparation are relatively complicated, and the production cost and production efficiency are difficult to control. Summary of the invention

[0004] In order to control the production cost of cancer analgesic Chinese medicine preparations and improve production efficiency, the present invention provides a Chinese medicine composition for treating pain, which comprises: Vinegar-processed Corydalis yanhusuo: 10%-25%; Vinegar-based neem: 8%-22%; Vinegar-processed aconite: 11%-30%; Vinegar-made frankincense: 14%-24%; Myrrh made from vinegar: 12%-22%.

[0005] In addition, based on the above-mentioned Chinese medicine composition, a Chinese medicine patch for treating pain is also proposed, which includes: a paste ointment, the paste ointment is covered on oil paper; the ingredients of the paste ointment include: 4-6 parts of the Chinese medicine composition, 3-5 parts of honey, and 0.5-2 parts of an auxiliary matrix, the above are weight parts; in the Chinese medicine composition, the components and weight proportions are as follows: Vinegar-processed Corydalis yanhusuo: 10%-25%; Vinegar-based neem: 8%-22%; Vinegar-processed aconite: 11%-30%; Vinegar-made frankincense: 14%-24%; Myrrh made from vinegar: 12%-22%.

[0006] Preferably, the auxiliary matrix is ​​hydroxymethylcoumarin.

[0007] Preferably, the ingredients of the paste ointment include: 5 parts of Chinese medicine composition, 4 parts of honey, and 1 part of auxiliary matrix, and the above are parts by weight.

[0008] Preferably, in the Chinese medicine composition, the components and their weight proportions are: Vinegar-processed Corydalis yanhusuo: 20%; Vinegar-based neem: 20%; Vinegar-processed aconite: 20%; Vinegar-made frankincense: 20%; Myrrh made from vinegar: 20%.

[0009] In addition, a method for preparing a Chinese medicine patch for treating pain is proposed, comprising the following steps: S1. The Corydalis yanhusuo, Chuanlianzi, Wulingzhi, frankincense, myrrh were vinegar, and after the vinegar was completed, 1 part by weight of each was weighed and powdered and mixed to form a Chinese medicine composition; S2. Weigh 4 parts by weight of honey and 1 part by weight of hydroxymethylcoumarin, and mix the traditional Chinese medicine composition prepared in step S1 with honey, and heat hydroxymethylcoumarin to boiling; S3. First, 1.5-2 parts by weight of water is added to the uniformly mixed traditional Chinese medicine composition and honey to dilute it, and then boiling hydroxymethylcoumarin is poured in, and stirred at high speed. While stirring, the stirred material is cooled and air-dried so that the temperature of the stirred material drops to 50°C-60°C within 10s-15s, and under the dual effects of stirring and air-drying, a viscous paste ointment is formed; S4. The paste ointment is evenly applied to the oil paper to prepare a patch; S5. After the patch is disinfected, coated, cut, and evacuated, it is packaged and shipped out.

[0010] Preferably, in step S1, after being crushed by vinegar, the Corydalis yanhusuo, Toosendan fruit, Aconiti lobata, frankincense and myrrh are put into a V-type mixer and stirred for 10-20 minutes.

[0011] Preferably, in step S2, the Chinese medicine composition and honey are put into a mixing tank and mixed for 15-20 minutes.

[0012] Preferably, the heating temperature of hydroxymethylcoumarin in the heating container in step S2 is 290°C±5°C, and in step S3, the mixing time of hydroxymethylcoumarin, the traditional Chinese medicine composition and honey is 10-20min; when the boiling hydroxymethylcoumarin is added into the traditional Chinese medicine composition, 0.5-1 parts by weight of dry ice is added for cooling, and air drying is performed using a cold air blower.

[0013] Vinegar Corydalis enhances its analgesic effect by processing Corydalis with vinegar. Corydalis itself has the effects of promoting blood circulation, promoting qi circulation, and relieving pain, and its analgesic effect is more obvious after being processed with vinegar. The acidic environment of vinegar helps the dissolution and transformation of the effective ingredients in Corydalis, thereby enhancing its pharmacological effects. Therefore, vinegar Corydalis can be widely used to treat a variety of pains, such as various pains caused by qi stagnation and blood stasis, pain caused by soft tissue contusion or visceral spasm, neuralgic pain, etc. In addition, vinegar Corydalis has a strong effect of promoting blood circulation and removing blood stasis, which can effectively relieve pain caused by qi and blood stagnation. At the same time, it can also promote blood circulation, improve local nutritional status, and is conducive to the repair and regeneration of damaged tissues. Vinegar Corydalis can also regulate the qi of the spleen and stomach and relieve pain caused by qi stagnation.

[0014] Vinegar-processed Toosendan fruit can significantly enhance its effect of promoting qi and relieving pain. Toosendan fruit itself has the effect of soothing the liver and relieving heat, promoting qi and relieving pain, and this effect is more obvious after being processed with vinegar. Vinegar-processed Toosendan fruit is particularly suitable for treating chest and flank pain. Chest and flank pain are mostly caused by liver qi stagnation, qi stagnation and blood stasis, and Toosendan fruit has the effect of soothing the liver and regulating qi, promoting blood circulation and removing blood stasis. After being processed with vinegar, it can more specifically relieve this symptom. Toosendan fruit itself has a therapeutic effect on epigastric, flank and rib pain, and hernia pain, and the effect is better after being processed with vinegar. The astringent nature of vinegar helps stabilize the medicinal properties, making the analgesic effect of Toosendan fruit more lasting.

[0015] After frying the aconite with vinegar, its blood circulation and blood stasis-removing effect is enhanced, which is specifically manifested in: enhancing blood circulation: vinegar-processed aconite can accelerate the body's blood circulation and metabolism, and help improve local swelling and pain symptoms caused by blood stasis; treating qi stagnation and blood stasis: vinegar-processed aconite has a good therapeutic effect on chest pain, abdominal pain, dysmenorrhea, amenorrhea, postpartum abdominal pain, and distension and pain after trauma caused by qi stagnation and blood stasis; relaxing muscles and promoting blood circulation: vinegar-processed aconite also has the effect of relaxing muscles and promoting blood circulation, and can be used to improve muscle spasms and pain caused by meridian tightness. In addition, vinegar-processed aconite contains rich volatile oils and flavonoids, which have strong anti-inflammatory and antibacterial effects. Studies have shown that vinegar-processed aconite has an inhibitory effect on a variety of bacteria, and cancer patients are prone to infection due to treatment or impaired immune systems, which can lead to inflammation, which can cause cell damage and death, thereby causing pain, etc. Vinegar-processed aconite can also play an anti-inflammatory and antibacterial role against this type of pain.

[0016] Vinegar frankincense has a significant effect of promoting blood circulation and relieving pain, and has a good effect on alleviating various pains caused by blood stasis: it can relieve pain by promoting blood circulation and eliminating blood stasis. In addition, vinegar frankincense can promote the increase of multinuclear leukocytes and improve metabolism, thereby playing an anti-inflammatory and bactericidal, swelling-reducing and muscle-promoting, anti-inflammatory and antiseptic role, promoting wound healing, inhibiting bacterial growth and reproduction, and preventing wound infection. The active ingredients in vinegar frankincense can also enhance the body's immune function and improve the body's resistance. It has a certain anti-inflammatory and analgesic effect on the pain caused by local infection caused by low immunity in cancer patients.

[0017] Vinegar-prepared myrrh can promote blood circulation and dissipate blood stasis. It has a good therapeutic effect on various diseases caused by blood stasis. This effect is due to the fact that vinegar itself has the effect of promoting blood circulation and removing blood stasis, and the effect is better when combined with myrrh. Myrrh vinegar can enhance the effect of dispersing nodules and relieving pain, dissipate lumps in the body, and relieve the pain caused by them. It is suitable for treating joint swelling and pain as well as pain caused by blood stasis. Vinegar-prepared myrrh also has a certain astringent effect, which can promote wound healing and muscle growth. Vinegar-prepared frankincense and vinegar-prepared myrrh play an important role in traditional Chinese medicine. They have a variety of effects such as strengthening blood circulation and removing blood stasis, promoting qi and relieving pain, reducing swelling and promoting muscle growth, promoting wound healing and inhibiting bacterial growth. They have obvious auxiliary analgesic effects on cancer patients with cancer pain caused by various factors.

[0018] The matrix of this product, Dantong, has an active ingredient of hydroxymethylcoumarin. As a pharmaceutical matrix, it plays a certain reinforcing role in assisting spasmolysis and analgesia, mainly related to its relaxation of smooth muscle and regulation of pain signals: Smooth muscle relaxation: Hydroxymethylcoumarin can relax smooth muscle by regulating calcium ion channels and other signal transduction pathways. This relaxation effect is very effective in relieving pain caused by smooth muscle spasms; Hydroxymethylcoumarin has certain anti-inflammatory properties and can inhibit the release of inflammatory mediators, thereby reducing pain caused by inflammation. For example, it reduces local inflammatory reactions by inhibiting leukocyte infiltration and inhibiting the synthesis of inflammatory factors; Affecting nerve conduction: Hydroxymethylcoumarin can reduce pain perception by affecting the nervous system. This can be achieved by inhibiting the conduction of pain signals or affecting the release of neurotransmitters. Therefore, using Dantong as a matrix can enhance the analgesic effect on pathological pain caused by nerve compression and nerve damage, as well as smooth muscle spasm pain caused by compression of organs.

[0019] The preparation of the present invention has obvious therapeutic effects such as promoting blood circulation and qi, removing blood stasis and relieving pain. After contacting the skin, the temperature rises, thereby promoting blood circulation, accelerating the absorption of the Chinese medicine plaster of the present invention, and promoting improvement of symptoms. The materials are all natural, environmentally friendly, safe and non-toxic. In addition, the preparation of the present invention has low cost and high production efficiency, and the effect of relieving cancer pain is better than similar products. DETAILED DESCRIPTION Example 1

[0020] The Chinese medicine composition for treating pain of the present invention comprises: Vinegar-processed Corydalis yanhusuo: 20%; Vinegar-based neem: 20%; Vinegar-processed aconite: 20%; Vinegar-made frankincense: 20%; Myrrh made from vinegar: 20%. Example 2

[0021] The Chinese medicine patch for treating pain of the present invention comprises: a paste ointment, which is covered on oil paper; the ingredients of the paste ointment include: 5 parts of Chinese medicine composition, 4 parts of honey, and 1 part of hydroxymethylcoumarin, and the above are parts by weight; in the Chinese medicine composition, the components and their weight proportions are as follows: Vinegar-processed Corydalis yanhusuo: 20%; Vinegar-based neem: 20%; Vinegar-processed aconite: 20%; Vinegar-made frankincense: 20%; Myrrh made from vinegar: 20%.

[0022] Preferably, the auxiliary matrix is ​​hydroxymethylcoumarin.

[0023] Preferably, the ingredients of the paste ointment include: 5 parts of Chinese medicine composition, 4 parts of honey, and 1 part of auxiliary matrix, and the above are parts by weight. Example 3

[0024] The method for preparing the Chinese medicine patch for treating pain described in Example 2 comprises the following steps: S1. The Corydalis yanhusuo, Chuanlianzi, Wulingzhi, frankincense, myrrh were vinegar, and after the vinegar was completed, 1 part by weight of each was weighed and powdered and mixed to form a Chinese medicine composition; S2. Weigh 4 parts by weight of honey and 1 part by weight of hydroxymethylcoumarin, and mix the traditional Chinese medicine composition prepared in step S1 with honey, and heat hydroxymethylcoumarin to boiling; S3. First, 1.5-2 parts by weight of water is added to the uniformly mixed traditional Chinese medicine composition and honey to dilute it, and then boiling hydroxymethylcoumarin is poured in, and stirred at high speed. While stirring, the stirred material is cooled and air-dried so that the temperature of the stirred material drops to 50°C-60°C within 10s-15s, and under the dual effects of stirring and air-drying, a viscous paste ointment is formed; S4. The paste ointment is evenly applied to the oil paper to prepare a patch; S5. After the patch is disinfected, coated, cut, and evacuated, it is packaged and shipped out.

[0025] Preferably, in step S1, after being crushed by vinegar, the Corydalis yanhusuo, Toosendan fruit, Aconiti lobata, frankincense and myrrh are put into a V-type mixer and stirred for 10-20 minutes.

[0026] Preferably, in step S2, the Chinese medicine composition and honey are put into a mixing tank and mixed for 15-20 minutes.

[0027] Preferably, the heating temperature of hydroxymethylcoumarin in the heating container in step S2 is 290°C±5°C, and in step S3, the mixing time of hydroxymethylcoumarin, the traditional Chinese medicine composition and honey is 10-20min; when the boiling hydroxymethylcoumarin is added into the traditional Chinese medicine composition, 0.5-1 parts by weight of dry ice is added for cooling, and air drying is performed using a cold air blower. Example 4

[0028] In order to verify the feasibility and practicality of introducing the unique ingredient hydroxymethylcoumarin in the preparation of the Chinese medicine patch of the present invention, the raw materials were treated as follows: control group a: powdered hydroxymethylcoumarin was mixed with the Chinese medicine composition and then mixed with honey, and stirred to obtain an ointment; control group b: a paste ointment obtained by the method described in Example 3; control group c: an ointment obtained by not diluting the Chinese medicine composition and not performing a rapid cooling operation when adding boiling hydroxymethylcoumarin; control group d: an ointment obtained by diluting the Chinese medicine composition and performing a rapid cooling operation when adding boiling hydroxymethylcoumarin, but not simultaneously air-drying. The types and weights of raw materials used in the above four control groups were equal, and the obtained products were observed and the patch penetration experiment was performed. The results are as shown in the following table:

[0029] As can be seen from the above table, the patch formed by the preparation method described in Example 2 has the best physical shape and drug penetration effect. Example 5

[0030] The Chinese medicine patch described in Example 2 was used clinically. Patient He, female, 64 years old, had lung cancer surgery 3 years ago. CEA increased and PET indicated pleural metastasis, and radiotherapy was performed. Genetic testing indicated EGFR19 mutation, and first-line treatment was performed. In October 2023, she complained of chest pain before and was given celecoxib orally without obvious effect. Diagnosis: Chinese medicine diagnosis: accumulation disease (Qi stagnation and blood stasis syndrome), Western medicine diagnosis: left pleural metastasis after surgery for adenocarcinoma of the left lung malignant tumor. Treatment: From December 2023, the prepared Chinese medicine preparation was used for 6 courses, and the pain disappeared. Follow-up observation for 1 month without recurrence. Example 6

[0031] The Chinese medicine patch described in Example 1 was used in a control experiment with a similar cancer pain relief patch. 100 patients were given clinical pain relief treatment, and 50 patients who used the preparation on the first day and the control preparation on the second day were group A, and another 50 patients who used the control preparation on the first day and the preparation on the second day were group B. After asking the patients about their physical sensations after the treatment, the statistics were as follows:

[0032] As can be seen from the above table, the Chinese medicine patch of the present invention has a better physical sensation in patients than similar cancer analgesic patches. Example 7

[0033] The proportion of each component in the patch was adjusted to form control group e, control group f, control group g, and control group h, wherein the Chinese medicine composition of control group e included: 1 part of Corydalis yanhusuo, 1 part of Chuanlianzi, 1 part of Pentaxylidum oleiferum, 1 part of frankincense, and 1 part of myrrh; the Chinese medicine composition of control group f included: 2 parts of Corydalis yanhusuo, 2 parts of Chuanlianzi, 1 part of Pentaxylidum oleiferum, 2 parts of frankincense, and 2 parts of myrrh; the Chinese medicine composition of control group g included: 2 parts of Corydalis yanhusuo, 1 part of Chuanlianzi, 1.5 parts of Pentaxylidum oleiferum, 1.5 parts of frankincense, and 2 parts of myrrh; the Chinese medicine composition of control group h The medicinal composition includes: 1.5 parts of Corydalis yanhusuo, 1.8 parts of Chuanlianzi, 1.2 parts of Penicillium truncatum, 1.5 parts of frankincense, and 1 part of myrrh; 40 healthy mice were selected and randomly divided into 4 groups, each with 10 mice. After feeding the mice with an appropriate amount of oxaliplatin for one week, the mice in the control group were treated and observed with the eh patch. The levels of pro-inflammatory cytokines IL-6 and TNF-α in the mice were measured on the 0th / 5th / 10th / 15th / 20th day of treatment, and the values ​​were determined according to the fluorescence kit method. The values ​​are as shown in the following table:

[0034] It can be seen from the above table that the levels of IL-6 and TNF-α in mice continue to decrease with the treatment time. The cumulative reduction values ​​of IL-6 and TNF-α in the mice of the control group e at each measurement time point are the lowest, so its analgesic effect is the most outstanding. The values ​​of IL-6 and TNF-α in the other control groups at each measurement time point are greater than those of the control group e, and the onset time is also delayed.

[0035] The preparation of the present invention has obvious therapeutic effects such as promoting blood circulation and qi, removing blood stasis and relieving pain. After contacting the skin, the temperature rises, thereby promoting blood circulation, accelerating the absorption of the Chinese medicine plaster of the present invention, and promoting improvement of symptoms. The materials are all natural, environmentally friendly, safe and non-toxic. In addition, the preparation of the present invention has low cost and high production efficiency, and the effect of relieving cancer pain is better than similar products.

[0036] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating pain, characterized in that: include: Vinegar-processed Corydalis yanhusuo: 10%-25%; Vinegar-based neem: 8%-22%; Vinegar-processed aconite: 11%-30%; Vinegar-made frankincense: 14%-24%; Myrrh made from vinegar: 12%-22%.

2. A Chinese medicine patch for treating pain, characterized in that: include: Paste ointment, the paste ointment is covered on oil paper; The ingredients of the paste ointment include: 4-6 parts of Chinese medicine composition, 3-5 parts of honey, and 0.5-2 parts of auxiliary matrix, the above are weight parts; in the Chinese medicine composition, the components and weight proportions are as follows: Vinegar-processed Corydalis yanhusuo: 10%-25%; Vinegar-based neem: 8%-22%; Vinegar-processed aconite: 11%-30%; Vinegar-made frankincense: 14%-24%; Myrrh made from vinegar: 12%-22%.

3. The Chinese medicine patch for treating pain according to claim 2, characterized in that: The auxiliary matrix is ​​hydroxymethylcoumarin.

4. The Chinese medicine patch for treating pain according to claim 3, characterized in that: The ingredients of the paste ointment include: 5 parts of Chinese medicine composition, 4 parts of honey, and 1 part of auxiliary matrix, and the above are parts by weight.

5. The Chinese medicine patch for treating pain according to claim 4, characterized in that: In the Chinese medicine composition, the components and their weight proportions are as follows: Vinegar-processed Corydalis yanhusuo: 20%; Vinegar-based neem: 20%; Vinegar-processed aconite: 20%; Vinegar-made frankincense: 20%; Myrrh made from vinegar: 20%.

6. A method for preparing a Chinese medicine patch for treating pain, characterized in that: The steps include: S1. The Corydalis yanhusuo, Chuanlianzi, Wulingzhi, frankincense, myrrh were vinegar, and after the vinegar was completed, 1 part by weight of each was weighed and powdered and mixed to form a Chinese medicine composition; S2. Weigh 4 parts by weight of honey and 1 part by weight of hydroxymethylcoumarin, and mix the traditional Chinese medicine composition prepared in step S1 with honey, and heat hydroxymethylcoumarin to boiling; S3. First, 1.5-2 parts by weight of water is added to the uniformly mixed traditional Chinese medicine composition and honey to dilute it, and then boiling hydroxymethylcoumarin is poured in, and stirred at high speed. While stirring, the stirred material is cooled and air-dried so that the temperature of the stirred material drops to 50°C-60°C within 10s-15s, and under the dual effects of stirring and air-drying, a viscous paste ointment is formed; S4. The paste ointment is evenly applied to the oil paper to prepare a patch; S5. After the patch is disinfected, coated, cut, and evacuated, it is packaged and shipped out.

7. The method for preparing the Chinese medicine patch for treating pain according to claim 6, characterized in that: In the step S1, after being crushed in vinegar, Corydalis yanhusuo, Toosendan fruit, Aconiti lobata, frankincense and myrrh are put into a V-type mixer and stirred for 10-20 minutes.

8. The method for preparing the Chinese medicine patch for treating pain according to claim 7, characterized in that: In step S2, the Chinese medicine composition and honey are put into a mixing tank and mixed for 15-20 minutes.

9. The method for preparing the Chinese medicine patch for treating pain according to claim 8, characterized in that: In step S2, the heating temperature of hydroxymethylcoumarin in the heating container is 290°C±5°C. In step S3, the mixing time of hydroxymethylcoumarin, the traditional Chinese medicine composition and honey is 10-20min. When the boiling hydroxymethylcoumarin is added into the traditional Chinese medicine composition, 0.5-1 parts by weight of dry ice is added for cooling, and air drying is performed using a cold air blower.

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