Asthma prescription for treating cough variant asthma and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an asthma prescription for treating cough variant asthma and a preparation method thereof. The asthma prescription for treating cough variant asthma is prepared from the following raw materials in parts by weight: honey-fried ephedra, semen armeniacae amarae, raw liquorice, earthworm, stiff silkworm, cicada slough, dark plum, folium mori, white mulberry root-bark, mint, radix peucedani and folium eriobotryae. In the formula, ephedra, lumbricus and folium mori are used as monarch drugs for dispelling wind and diffusing lung; semen armeniacae amarae, white mulberry root-bark, radix peucedani and folium eriobotryae The bombyx batryticatus, the cicada slough and the mint help the monarch drug to dispel wind, and the dark plum astringes And liquorice is used as a conductant drug for harmonizing the medicines. According to the asthma prescription, the cough frequency of a cough variant asthma model is remarkably reduced, the concentration of IgE, IL-6 and ICAM-1 in serum is adjusted, and the asthma prescription has a treatment effect on the cough variant asthma.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an asthma prescription for treating cough variant asthma and a preparation method thereof. Background Art

[0002] Cough variant asthma is a special type of asthma with chronic cough as the main or only clinical manifestation. The etiology and pathogenesis of cough variant asthma have not been fully elucidated. It is currently believed that cough variant asthma is affected by multiple factors such as genetics, environment, immunity, and infection. Its pathogenesis is similar to that of typical asthma, mainly related to airway inflammation, airway hyperresponsiveness, and airway remodeling. The main clinical diagnostic manifestations of cough variant asthma are persistent and repetitive irritating dry coughs that are more obvious at night, often accompanied by itchy and dry throats. There is no obvious shortness of breath during the onset, and there is more obvious airway hyperresponsiveness.

[0003] Western medicine commonly uses drugs such as bronchodilators, glucocorticoids and leukotriene receptor antagonists for clinical treatment, but the course of treatment is long, and it is easy to relapse after stopping the drug, which is difficult to cure. In addition, long-term use of drugs may increase drug toxicity and side effects, affect medication compliance, and some patients still have contraindications, and the effect is not ideal. With the continuous development of traditional Chinese medicine, the understanding of the name, etiology, pathogenesis and clinical treatment of cough variant asthma has gradually deepened. The ideas of syndrome differentiation treatment, disease location treatment, disease stage treatment, treatment from the six meridians theory and collateral disease theory, and the increase in modern single-herb and Chinese medicine compound experimental and clinical research have provided more possibilities for the treatment of cough variant asthma with traditional Chinese medicine. Summary of the invention

[0004] The purpose of the present invention is to provide an asthma prescription for treating cough variant asthma according to the deficiencies of the prior art, and a preparation method and application thereof. The asthma prescription of the present invention significantly reduces the number of coughs in a cough variant asthma model, regulates the concentrations of IgE, IL-6, and ICAM-1 in serum, and has a therapeutic effect on cough variant asthma.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] The first aspect of the present invention provides an asthma prescription for treating cough variant asthma, which is prepared from honey ephedra, bitter almonds, raw licorice, earthworms, silkworm pupa, cicada shells, black plums, mulberry leaves, mulberry bark, mint, peucedanum chinense and loquat leaves.

[0007] Furthermore, the asthma prescription for treating cough variant asthma is made of the following raw materials in parts by weight: 4-8 parts of honey ephedra, 6-12 parts of bitter almonds, 6-12 parts of raw licorice, 5-15 parts of earthworms, 6-12 parts of silkworm pupa, 6-12 parts of cicada shells, 4-8 parts of black plums, 5-15 parts of mulberry leaves, 10-20 parts of mulberry bark, 6-12 parts of mint, 10-20 parts of peucedanum chinense and 10-20 parts of loquat leaves.

[0008] Furthermore, the asthma prescription for treating cough variant asthma is made of the following raw materials in parts by weight: 6 parts of honey ephedra, 9 parts of bitter almonds, 9 parts of raw licorice, 10 parts of earthworms, 9 parts of silkworms, 9 parts of cicada shells, 6 parts of black plums, 10 parts of mulberry leaves, 15 parts of mulberry bark, 9 parts of mint, 15 parts of peucedanum and 15 parts of loquat leaves.

[0009] The asthma prescription of the present invention also includes pharmaceutically acceptable excipients, including but not limited to solvents, solubilizers, co-solvents, colorants, disintegrants, fillers, lubricants, wetting agents, stabilizers, flavoring agents, preservatives, suspending agents, coating materials, anti-adhesive agents, integrators, plasticizers, etc.

[0010] The Chinese medicine of the present invention is prepared into various clinically acceptable dosage forms by adding conventional auxiliary materials according to conventional pharmacy methods, including but not limited to tablets, capsules, oral liquids, lozenges, granules, granules, pills, drops, powders, pastes, pills, suspensions, powders, solutions, injections, suppositories, ointments, plasters, creams, sprays, and patches. Tablets are ordinary tablets, sugar-coated tablets, and film tablets.

[0011] Furthermore, the dosage form of the asthma prescription for treating cough variant asthma is decoction, granules, tablets, capsules, mixtures, syrups, pills, gels, powders or ointments.

[0012] Furthermore, the dosage form of the asthma prescription for treating cough variant asthma is granules.

[0013] The second aspect of the present invention provides a method for preparing the asthma prescription for treating cough variant asthma, which is as follows: after combining the medicinal materials, add water and boil twice, the first time adding water is 6-8 times the weight of the medicinal materials, and boiling for 2-3h, the second time adding water is 6-8 times the weight of the medicinal materials, and boiling for 2-3h, and the decoctions are combined.

[0014] Furthermore, the preparation method of the present invention is as follows: after combining the medicinal materials, add water and boil twice, the first time adding water is 8 times the weight of the medicinal materials, boiling for 3 hours, the second time adding water is 6 times the weight of the medicinal materials, boiling for 2 hours, and combining the decoctions.

[0015] The third aspect of the present invention provides use of the asthma prescription for treating cough variant asthma in preparing a medicament for preventing or treating cough variant asthma.

[0016] In the asthma prescription of the present invention, the pharmacological effects of each Chinese medicine component are as follows:

[0017] Honey Ephedra: It tastes spicy and slightly bitter, is warm in nature, and enters the lung and bladder meridians. It can induce sweating and relieve exterior symptoms, promote lung function and relieve asthma, promote diuresis and reduce swelling, and dispel cold and relieve stagnation. It is used for wind-cold exterior symptoms, chest tightness, cough and asthma, wind-water edema, wind-cold arthralgia, yin carbuncle, phlegm nodules, etc.

[0018] Bitter almond: bitter in taste, slightly warm in nature, enters the lung and large intestine meridians, also known as almond, has the effects of lowering qi, relieving cough and asthma, moistening the intestines and promoting bowel movements, and is used for symptoms such as cough and asthma, chest fullness and phlegm, blood deficiency and dry body fluids, dry intestines and constipation.

[0019] Raw licorice: sweet in taste, neutral in nature, enters the heart, lung, spleen, and stomach meridians, tonifies the spleen and replenishes qi, clears away heat and detoxifies, removes phlegm and relieves cough, relieves pain, and harmonizes various medicines.

[0020] Earthworm: salty in taste, cold in nature, enters the liver, lung, spleen, and bladder meridians, clears away heat and calms convulsions, dredges the meridians, relieves asthma, and is a diuretic; used for high fever and convulsions, convulsions of the hands and feet, cough and asthma due to lung heat, joint pain, hemiplegia, and heat-stagnation and urinary retention.

[0021] Bombyx batryticatus: salty and spicy in taste, neutral in nature, enters the liver, lung and stomach meridians, can calm wind and stop convulsions, dispel wind and relieve pain, resolve phlegm and disperse nodules; used for aphonia caused by stroke, epilepsy, head wind, wind sores, rashes, erysipelas, and mastitis.

[0022] Cicada shell: sweet in taste, salty and cold in nature, enters the lung and liver meridians, dispels wind and heat, relieves sore throat and rashes, removes cataracts and improves eyesight, and relieves spasms; used for wind-heat colds, sore throats, hoarseness, measles that does not break out, itchy rubella, red eyes and cataracts, convulsions, tetanus and other symptoms.

[0023] Black plum: sour and astringent in taste, neutral in nature, enters the liver, spleen, lung, and large intestine meridians, astringes the lungs, astringes the intestines, promotes the production of body fluids, and calms ascaris; used for chronic cough due to lung deficiency, chronic diarrhea and dysentery, deficiency heat and thirst, ascariasis, vomiting and abdominal pain.

[0024] Mulberry leaves: sweet and bitter in taste, cold in nature, enter the lung and liver meridians, dispel wind-heat, clear the lungs and moisten dryness, clear the liver and improve eyesight; used to treat wind-heat colds, lung heat and dry coughs, dizziness and headaches, and red and blurred eyes.

[0025] Mulberry bark: sweet in taste, cold in nature, enters the lung and spleen meridians, clears the lungs and relieves asthma, promotes diuresis and reduces swelling, replenishes deficiency, promotes blood circulation and removes blood stasis, resolves phlegm and relieves cough, stops bleeding, expels parasites, helps digestion, dispels wind, relieves stranguria, and relieves pain.

[0026] Mint: spicy, warm in nature, non-toxic, enters the lung and liver meridians, eliminates wind and dissipates heat; used for influenza, headache, red eyes, fever, sore throat, swollen and painful gums, etc.

[0027] Peucedanum: bitter and pungent in taste, slightly cold in nature, enters the lung, spleen, and liver meridians, descends qi and resolves phlegm, dispels wind and clears heat; used for symptoms such as phlegm-heat wheezing, coughing up yellow and thick sputum, wind-heat cough with excessive sputum, etc.

[0028] Loquat leaves: bitter in taste, slightly cold in nature, enter the lung and stomach meridians, clear the lungs and relieve cough, harmonize the stomach and promote urination, quench thirst, have the effects of treating lung heat, phlegm cough, qi reversal and wheezing, and calming the respiratory center, and have a good effect on patients with wheezing.

[0029] In the asthma prescription of the present invention, ephedra, earthworm and mulberry leaf are used as main drugs to dispel wind and promote lung function; bitter almond, mulberry bark, peucedanum chinense and loquat leaf are used as assistant drugs to relieve lung function and relieve cough; silkworm, cicada shell and mint assist the main drugs to dispel wind; black plum is used to astringe the lung and relieve cough; and liquorice is used as a guiding drug to harmonize various drugs.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] The asthma prescription of the present invention can significantly reduce the cough frequency of the cough variant asthma model, regulate the concentrations of IgE, IL-6 and ICAM-1 in serum, and has a therapeutic effect on cough variant asthma.

[0032] The asthma prescription of the present invention has a simple composition, is easy to take, safe and reliable, has no toxic and side effects, and has a significant effect. It provides a convenient, effective, and non-toxic and side-effect-free medicine for the clinical treatment of cough variant asthma, and has high practical value. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 Comparison of cough frequency among rats in each group on the second day after administration. Different lowercase letters above the bar graph indicate significant differences among different groups (P<0.05).

[0034] Figure 2 Comparison of cough frequency among rats in each group on the 6th day after administration. Different lowercase letters above the bar graph indicate significant differences among different groups (P<0.05).

[0035] Figure 3 Comparison of IgE levels in rats of each group. Different lowercase letters above the bar graph indicate significant differences among different groups (P<0.05).

[0036] Figure 4 Comparison of IL-6 levels in rats of each group. Different lowercase letters above the bar graph indicate significant differences among different groups (P<0.05).

[0037] Figure 5 Comparison of ICAM-1 levels among rats in each group. Different lowercase letters above the bar graph indicate significant differences among different groups (P<0.05). DETAILED DESCRIPTION

[0038] The embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention.

[0039] Example 1

[0040] Honey ephedra 6g, bitter almond 9g, raw licorice 9g, earthworm 10g, silkworm 9g, cicada shell 9g, black plum 6g, mulberry leaf 10g, mulberry bark 15g, mint 9g, peucedanum 15g and loquat leaf 15g.

[0041] Preparation method: After combining the medicinal materials, add water and boil twice. The first time, add water in an amount of 8 times the weight of the medicinal materials and boil for 3 hours. The second time, add water in an amount of 6 times the weight of the medicinal materials and boil for 2 hours. Combine the decoctions.

[0042] Example 2

[0043] Honey ephedra 4g, bitter almond 12g, raw licorice 6g, earthworm 15g, silkworm 6g, cicada shell 12g, black plum 4g, mulberry leaf 15g, mulberry bark 10g, mint 12g, peucedanum 10g and loquat leaf 20g.

[0044] Preparation method: After combining the medicinal materials, add water and boil twice. The first time, add water that is 7 times the weight of the medicinal materials and boil for 2.5 hours. The second time, add water that is 8 times the weight of the medicinal materials and boil for 2 hours. Combine the decoctions.

[0045] Example 3

[0046] Honey ephedra 8g, bitter almond 6g, raw licorice 12g, earthworm 5g, silkworm 12g, cicada shell 6g, black plum 8g, mulberry leaf 5g, mulberry bark 20g, mint 6g, peucedanum 20g and loquat leaf 10g.

[0047] Preparation method: After combining the medicinal materials, add water and boil twice. The first time, add water that is 6 times the weight of the medicinal materials and boil for 2 hours. The second time, add water that is 8 times the weight of the medicinal materials and boil for 3 hours. Combine the decoctions.

[0048] Example 4

[0049] Honey ephedra 6g, bitter almond 12g, raw licorice 6g, earthworm 10g, silkworm 9g, cicada shell 6g, black plum 4g, mulberry leaf 9g, mulberry bark 10g, mint 9g, peucedanum 10g and loquat leaf 15g.

[0050] Preparation method: After combining the medicinal materials, add water and boil twice. The first time, add water that is 6 times the weight of the medicinal materials and boil for 2.5 hours. The second time, add water that is 6 times the weight of the medicinal materials and boil for 2.5 hours. Combine the decoctions.

[0051] Example 5

[0052] Honey ephedra 4g, bitter almond 9g, raw licorice 12g, earthworm 5g, silkworm 12g, cicada shell 12g, black plum 8g, mulberry leaf 15g, mulberry bark 20g, mint 12g, peucedanum 20g and loquat leaf 20g.

[0053] Preparation method: After combining the medicinal materials, add water and boil twice. The first time, add water in an amount of 8 times the weight of the medicinal materials and boil for 3 hours. The second time, add water in an amount of 6 times the weight of the medicinal materials and boil for 2 hours. Combine the decoctions.

[0054] Example 6

[0055] Honey ephedra 8g, bitter almond 8g, raw licorice 9g, earthworm 12g, silkworm 6g, cicada shell 9g, black plum 6g, mulberry leaf 5g, mulberry bark 15g, mint 6g, peucedanum 15g and loquat leaf 10g.

[0056] Preparation method: After combining the medicinal materials, add water and boil twice. The first time, add water that is 6 times the weight of the medicinal materials and boil for 2.5 hours. The second time, add water that is 6 times the weight of the medicinal materials and boil for 2.5 hours. Combine the decoctions.

[0057] Comparative Example 1

[0058] Bitter almond 9g, raw licorice 9g, earthworm 13g, silkworm 9g, cicada shell 9g, black plum 6g, mulberry leaf 13g, mulberry bark 15g, mint 9g, peucedanum 15g and loquat leaf 15g.

[0059] Compared with Example 1, the invention does not contain honey ephedra, and the dosage of earthworm and mulberry leaf is different, while other ingredients and contents remain unchanged.

[0060] The preparation method is similar to that of Example 1.

[0061] Comparative Example 2

[0062] Honey ephedra 11g, bitter almond 9g, raw licorice 9g, silkworm 9g, cicada shell 9g, black plum 6g, mulberry leaf 15g, mulberry bark 15g, mint 9g, peucedanum 15g and loquat leaf 15g.

[0063] Compared with Example 1, the invention does not contain earthworms, the dosages of ephedra and mulberry leaves are different, and the other components and contents remain unchanged.

[0064] The preparation method is similar to that of Example 1.

[0065] Comparative Example 3

[0066] Honey ephedra 11g, bitter almond 9g, raw licorice 9g, earthworm 15g, silkworm 9g, cicada shell 9g, black plum 6g, mulberry bark 15g, mint 9g, peucedanum 15g and loquat leaf 15g.

[0067] Compared with Example 1, mulberry leaves are not contained, the dosage of ephedra and earthworm is different, and other ingredients and contents remain unchanged.

[0068] The preparation method is similar to that of Example 1.

[0069] Comparative Example 4

[0070] Honey ephedra 6g, bitter almond 9g, raw licorice 9g, earthworm 10g, silkworm 9g, cicada shell 9g, black plum 6g, mulberry leaf 10g, mulberry bark 15g, mint 9g and loquat leaf 20g.

[0071] Compared with Example 1, the invention does not contain Peucedanum praeruptorum, and the dosages of bitter almond, white mulberry bark and loquat leaf are different, while the other components and contents remain unchanged.

[0072] The preparation method is similar to that of Example 1.

[0073] Comparative Example 5

[0074] 10g of black plum, 10g of mulberry leaf, 10g of mulberry bark, 10g of bombyx batryticatus, 6g of cicada shell, 15g of white peony root, 6g of schisandra chinensis, 6g of roasted licorice, 10g of almond, 15g of loquat leaf, 10g of chrysanthemum, and 10g of platycodon.

[0075] The preparation method is similar to that of Example 1.

[0076] Efficacy Example The therapeutic effect of the asthma prescription of the present invention on rats with cough variant asthma

[0077] 1. Experimental Methods

[0078] SPF male SD rats, weighing 160-200g, were given free access to water and food, and the room temperature was maintained at 20-25°C. After passing the quarantine for 7 days, 10 rats were randomly selected as the normal control group, and the remaining rats were used for modeling.

[0079] Except for the normal control group, each group was injected subcutaneously with 1 mg / mL egg protein solution (containing 100 mg egg protein, 0.25 ml aluminum hydroxide, and 0.75 ml normal saline). Ten points, including the soles of both hind paws, groin, waist, back, and neck, were injected with 0.05 mL at each point, and 0.5 mL was injected intraperitoneally at the same time. The injection was boosted once after 1 week.

[0080] Nebulizer inhalation on the morning of the 15th day after modeling: The rats were placed in a 4L glass bell jar and sprayed with 1% egg protein solution at a constant pressure of 400 mmHg for 20 minutes using an ultrasonic nebulizer to stimulate asthma. Positive results were determined by obvious contraction of the rats' abdominal muscles, deeper and faster breathing, etc., indicating that the modeling was successful.

[0081] The rats with successful modeling were randomly divided into model control group, Example 1 group, Example 2 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, and Comparative Example 4 group, with 10 rats in each group. -4 mol / L capsaicin solution was used to induce wheezing and coughing once, and the number of coughs within 2 minutes was recorded. The drug was administered intragastrically once in the afternoon. Each group was intragastrically administered with the corresponding decoction at a dose of 3.6 g / kg, and the normal control group and the model control group were intragastrically administered with an equal volume of saline. The drug was administered once a day for 6 days.

[0082] 2. Sample collection and indicator testing

[0083] 2.1 Record the number of coughs

[0084] On the 2nd and 6th day after administration, the coughing times of rats in each group within 2 min were recorded using a cough-inducing wheeze instrument.

[0085] 2.2 Determination of serum IgE, IL-6, and ICAM-1 levels

[0086] The eyeballs were removed, blood was collected, and the blood was centrifuged for 10 min (1500 r / min) to obtain serum, and the procedure was performed according to the instructions of the enzyme-linked immunosorbent assay kit.

[0087] 3. Statistical methods

[0088] Graphpad Prism 9.0 software was used for data processing, and the measured data were expressed as mean ± standard deviation ( ) indicated that one-way analysis of variance was used for comparison among multiple groups, and SNK-q was used for pairwise comparison among groups. The difference was considered statistically significant when P < 0.05.

[0089] 4. Experimental Results

[0090] 4.1 Effect on the number of coughs

[0091] Compared with the normal control group, the cough frequency of the model control group increased significantly, indicating that the cough variant asthma rat model was successfully established. Compared with the model control group, the cough frequency of Example 1 and Example 2 groups decreased significantly, and the effect of Example 1 on improving the cough frequency was the best, which was significantly better than the control groups. The cough frequency of rats in each group on the second day after administration was shown in Table 1. Figure 1 , the number of coughs on the 6th day after administration Figure 2 .

[0092] 4.2 Effects on serum IgE, IL-6, and ICAM-1 levels

[0093] Compared with the normal control group, the IgE, IL-6, and ICAM-1 levels of the model control group rats were significantly increased. Compared with the model control group, the IgE, IL-6, and ICAM-1 levels of the Example 1 group and the Example 2 group were significantly reduced. The Example 1 group had the best effect in reducing the IgE, IL-6, and ICAM-1 levels, which was significantly better than the control groups. Figure 3 , Figure 4 , Figure 5 .

[0094] IgE-mediated type I allergic reaction plays a major role in the pathogenesis of cough variant asthma. IL-6 and ICAM-1 play an important role in airway mucosal inflammation and airway hyperresponsiveness in the cough variant asthma model. IL-6 is the main mediator of inflammatory and immune responses. Increased local synthesis and release of IL-6 plays an important role in asthma inflammatory response and increased airway responsiveness. ICAM-1 provides costimulatory signals for T cell activation, participates in inflammation, phagocytosis, and adhesion and recirculation of lymphocytes, and is closely related to the occurrence and development of cough variant asthma.

[0095] The asthma prescription of the present invention can significantly reduce the cough frequency of the cough variant asthma model, regulate the concentrations of IgE, IL-6 and ICAM-1 in serum, and has a therapeutic effect on cough variant asthma.

[0096] The present invention has been described in detail above with general descriptions and specific embodiments. However, it is obvious to those skilled in the art that some modifications or improvements may be made based on the present invention.

[0097] Therefore, all modifications or improvements made without departing from the spirit of the present invention belong to the scope of protection required by the present invention.

Claims

1. An asthma prescription for treating cough variant asthma, characterized in that: The asthma prescription for treating cough variant asthma is prepared from the following raw materials in parts by weight: 4-8 parts of honey ephedra, 6-12 parts of bitter almonds, 6-12 parts of raw licorice, 5-15 parts of earthworms, 6-12 parts of silkworm pupa, 6-12 parts of cicada shells, 4-8 parts of black plums, 5-15 parts of mulberry leaves, 10-20 parts of mulberry bark, 6-12 parts of mint, 10-20 parts of peucedanum chinense and 10-20 parts of loquat leaves.

2. The asthma prescription for treating cough variant asthma according to claim 1, characterized in that: The asthma prescription for treating cough variant asthma is prepared from the following raw materials in parts by weight: 6 parts of honey ephedra, 9 parts of bitter almonds, 9 parts of raw licorice, 10 parts of earthworms, 9 parts of silkworm pupa, 9 parts of cicada shells, 6 parts of black plums, 10 parts of mulberry leaves, 15 parts of mulberry bark, 9 parts of mint, 15 parts of peucedanum chinense and 15 parts of loquat leaves.

3. The asthma prescription for treating cough variant asthma according to any one of claims 1 to 2, characterized in that: The asthma prescription for treating cough variant asthma also includes pharmaceutically acceptable excipients.

4. The asthma prescription for treating cough variant asthma according to claim 3, characterized in that: The asthma prescription for treating cough variant asthma is a clinically acceptable dosage form.

5. The asthma prescription for treating cough variant asthma according to claim 4, characterized in that: The dosage form of the asthma prescription for treating cough variant asthma is decoction, granules, tablets, capsules, mixtures, syrups, pills, gels, powders or pastes.

6. The asthma prescription for treating cough variant asthma according to claim 4, characterized in that: The dosage form of the asthma prescription for treating cough variant asthma is granules.

7. The asthma prescription for treating cough variant asthma according to any one of claims 1-2, characterized in that: The preparation method of the asthma prescription for treating cough variant asthma is as follows: after combining the medicinal materials, add water and boil twice, the first time adding water is 6-8 times the weight of the medicinal materials, boiling for 2-3 hours, the second time adding water is 6-8 times the weight of the medicinal materials, boiling for 2-3 hours, and the liquid is combined and boiled.

8. The asthma prescription for treating cough variant asthma according to any one of claims 1-2, characterized in that: The preparation method of the asthma prescription for treating cough variant asthma is as follows: after combining the medicinal materials, add water and boil twice, the first time adding water is 8 times the weight of the medicinal materials, boiling for 3 hours, the second time adding water is 6 times the weight of the medicinal materials, boiling for 2 hours, and combining the decoctions.

9. Use of the asthma prescription for treating cough variant asthma according to any one of claims 1 to 2 in the preparation of a medicament for preventing or treating cough variant asthma.

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