External traditional Chinese medicine spray for treating shoulder, neck, waist and leg pain and preparation method of external traditional Chinese medicine spray

Abstract

The invention discloses a traditional Chinese medicine external spray for treating shoulder, neck, waist and leg pain and a preparation method thereof. The traditional Chinese medicine external spray is characterized by comprising the following components in parts by weight: 6-10 parts of radix aconiti preparata, 6-10 parts of prepared kusnezoff monkshood root, 10-15 parts of safflower, 10-12 parts of ligusticum wallichii, 10-15 parts of beefwood-like clubmoss herb, 5-8 parts of scorpion, 3-5 parts of asarum, 10-12 parts of salvia miltiorrhiza, 8-10 parts of yellow ginger and 2-4 parts of borneol. According to the external traditional Chinese medicine spray for treating shoulder, neck, waist and leg pain and the preparation method of the external traditional Chinese medicine spray, the effects of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and activating meridians to stop pain can be achieved on local swelling and pain caused by shoulder, neck, waist and leg pain such as cervical spondylosis, lumbar disc herniation, lumbar muscle degeneration, rheumatic arthritis, rheumatoid arthritis and traumatic injuries.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparations, and in particular to a traditional Chinese medicine microemulsion gel spray for treating pain in the shoulder, neck, waist and legs and a preparation method thereof. Background Art

[0002] Shoulder, neck, waist and leg pain is a common and frequently occurring disease, which seriously affects the quality of life of patients. At present, commonly used clinical treatment methods include drug therapy, physical therapy and surgical treatment. Among them, drug therapy is oral and topical, such as plasters and patches, but there are still the following problems: 1. The drug transdermal rate is low, and the onset time is usually more than 30 minutes, which is difficult to meet the needs of rapid relief of acute pain; 2. Existing technologies mostly target a single pathological mechanism, such as only anti-inflammatory or analgesic, and lack multi-target synergistic effects; 3. Oral drugs such as non-steroidal anti-inflammatory drugs are prone to cause systemic side effects such as gastrointestinal irritation and liver and kidney toxicity; 4. Traditional plasters and patches need to be applied for a long time, which can easily cause skin discomfort, and cannot achieve local precision drug delivery, affecting patient compliance. Summary of the invention

[0003] In order to overcome the deficiencies in the background technology, the present invention discloses a Chinese medicine external spray for treating shoulder, neck, waist and leg pain and a preparation method thereof.

[0004] In order to achieve the above-mentioned invention object, the present invention adopts the following technical scheme: A Chinese medicine external spray for treating shoulder, neck, waist and leg pain and a preparation method thereof, comprising the following components by weight: 6-10 parts of processed Chuanwu, 6-10 parts of processed Caowu, 10-15 parts of safflower, 10-12 parts of Chuanxiong, 10-15 parts of Shujincao, 5-8 parts of scorpion, 3-5 parts of asarum, 10-12 parts of salvia miltiorrhiza, 8-10 parts of turmeric, and 2-4 parts of borneol; The preparation method comprises the following steps: (1) pretreatment of raw materials: processing and reducing the toxicity of processed Chuanwu and processed Caowu, and then crushing the above-mentioned Chinese medicines except borneol into coarse powder, passing through a 40-mesh sieve, and mixing evenly; Step (2) extraction: placing the uniformly mixed drug powder into a sealed container, adding 60% medical alcohol, with a drug-liquid weight ratio of 1:6-8, soaking at room temperature for 7-10 days, stirring twice a day, filtering after the first extraction, performing a second extraction on the drug residue filtered out from the first extraction, adding 60% medical alcohol, with a residue-liquid weight ratio of 1:3-4, soaking for 5 days, and combining the filtrates obtained from the two extractions; Step (3) concentration and preparation: let the filtrate stand for 48 hours, take the supernatant, add borneol to dissolve, adjust the pH to 5.5-6.5, concentrate to 1 / 3 of the original volume and adjust the alcohol concentration to 50-55%; Step (4) Packaging and sterilization: Fill into spray bottles, sterilize by ultraviolet irradiation, and store in a sealed container.

[0005] Preferably, after the pH value adjustment in step (3) is completed, the solution is mixed with 5-10 parts by weight of Tween 80, 1-3 parts of oil phase, and 25-50 parts of water and stirred evenly to form a transparent or translucent microemulsion, 0.5-2 parts of gel matrix are dispersed in water, and allowed to swell for 12 hours, the microemulsion is slowly added to the gel matrix solution while stirring until a uniform gel is formed, 25-50 parts of water are added to the gel, concentrated to 1 / 3 of the original volume and the alcohol concentration is adjusted to 50-55%, filled into a spray bottle, sterilized by ultraviolet irradiation, and sealed for storage.

[0006] Preferably, the oil phase is one of menthol or camphor.

[0007] Preferably, the gel matrix is ​​carbomer 940 or hydroxypropyl methylcellulose.

[0008] Due to the adoption of the above-mentioned technical solution, the present invention has the following beneficial effects: The Chinese medicine ingredients of the present invention are reasonably formulated: 1. The main drug (dominant effect): Processed Chuanwu: dispels wind and dampness, warms the meridians and relieves pain, and is targeted at pain caused by cold and dampness.

[0009] Processed Caowu: Works synergistically with Chuanwu to enhance the effects of dispelling cold and relieving pain, and is especially good at relieving stubborn cold pain in joints.

[0010] Safflower: promotes blood circulation and relieves menstruation, dissipates blood stasis and relieves pain, improves local blood circulation.

[0011] 2. Assistant medicine (auxiliary and synergistic): Chuanxiong: promotes qi and blood circulation, dispels wind and relieves pain, and relieves muscle spasms.

[0012] Shujincao: also known as stretching grass, it can relax muscles and tendons, and relieve joint flexion and extension problems.

[0013] Scorpion: Unblocks meridians and relieves pain, removes wind and expels evil, and is effective for treating intractable neuralgia.

[0014] 3. Auxiliary drugs (harmony and efficacy): Asarum: warms the meridians and dispels cold, opens the orifices and relieves pain, and promotes drug penetration.

[0015] Salvia miltiorrhiza: promotes blood circulation and removes blood stasis, cools blood and reduces swelling, and balances the warming and dryness properties of the medicine.

[0016] Turmeric: Also known as turmeric, it can promote blood circulation, stimulate qi, relieve menstruation and relieve pain, and enhance anti-inflammatory effects.

[0017] Borneol: promotes penetration and guides the meridians, accelerates drug absorption, and relieves acute pain.

[0018] 60% medical alcohol: a solvent and penetration enhancer, extracting active ingredients and enhancing transdermal absorption.

[0019] The invention discloses a Chinese medicine external spray for treating pain in the shoulder, neck, waist and legs and a preparation method thereof. The Chinese medicine external spray can promote blood circulation and remove blood stasis, dispel wind and dampness, and relieve pain in the shoulder, neck, waist and legs, such as local swelling and pain caused by cervical spondylosis, lumbar disc herniation, lumbar muscle strain, rheumatoid arthritis, rheumatoid arthritis and traumatic injury.

[0020] The present invention utilizes processed Chuanwu and processed Caowu to inhibit inflammatory factors, combines safflower and salvia miltiorrhiza to improve microcirculation, and uses scorpion to block pain signal conduction, thereby achieving simultaneous action on multiple targets and effectively improving the therapeutic effect on shoulder, neck, waist and leg pain.

[0021] The present invention delivers precise local drug administration through a spray, enhances drug permeability through alcohol, and increases the speed of onset of action through borneol, thereby further improving the therapeutic effect on shoulder, neck, waist and leg pain.

[0022] The present invention improves the permeability of the drug by using microemulsion technology in the preparation process, so that the drug can quickly reach the affected area and take effect quickly.

[0023] The gel matrix of the present invention realizes sustained release and enhances the action time of the drug on the affected part. DETAILED DESCRIPTION Example 1

[0024] Weigh 8 parts of processed Chuanwu, 8 parts of processed Caowu, 12 parts of Carthamus tinctorius, 10 parts of Chuanxiong, 12 parts of Herba Lycopodii, 6 parts of Scorpio, 4 parts of Asarum, 10 parts of Salvia miltiorrhiza, 9 parts of Dioscorea turmeric, and 3 parts of Borneol.

[0025] Step (1) raw material pretreatment: processing and reducing the toxicity of processed Chuanwu and processed Caowu, then grinding the above-mentioned traditional Chinese medicines except borneol and medical alcohol into coarse powder, passing through a 40-mesh sieve, and mixing evenly; Step (2) extraction: placing the uniformly mixed drug powder into a sealed container, adding 60% medical alcohol, with a drug-liquid weight ratio of 1:7, soaking at room temperature for 7 days, stirring twice a day, filtering after the first extraction, performing a second extraction on the drug residue filtered out from the first extraction, adding 60% medical alcohol, with a residue-liquid weight ratio of 1:3, soaking for 5 days, and combining the filtrates obtained from the two extractions; Step (3) Concentration and preparation: let the filtrate stand for 48 hours, take the supernatant, add borneol to dissolve, adjust the pH to 6, concentrate to 1 / 3 of the original volume and adjust the alcohol concentration to 50%; Step (4) Packaging and sterilization: Fill into spray bottles, sterilize by ultraviolet irradiation, and store in a sealed container. Example 2

[0026] Weigh 7 parts of processed Chuanwu, 7 parts of processed Caowu, 11 parts of Carthamus tinctorius, 12 parts of Chuanxiong, 13 parts of Herba Lycopodii, 6 parts of Scorpio, 3 parts of Asarum, 10 parts of Salvia miltiorrhiza, 8 parts of Dioscorea turmeric, and 2 parts of Borneol.

[0027] Step (1) raw material pretreatment: processing and reducing the toxicity of processed Chuanwu and processed Caowu, then grinding the above-mentioned traditional Chinese medicines except borneol and medical alcohol into coarse powder, passing through a 40-mesh sieve, and mixing evenly; Step (2) extraction: placing the uniformly mixed drug powder into a sealed container, adding 60% medical alcohol, with a drug-liquid weight ratio of 1:8, soaking at room temperature for 8 days, stirring twice a day, filtering after the first extraction, performing a second extraction on the drug residue filtered out from the first extraction, adding 60% medical alcohol, with a residue-liquid weight ratio of 1:3, soaking for 5 days, and combining the filtrates obtained from the two extractions; Step (3) concentration and preparation: the filtrate is allowed to stand for 48 hours, the supernatant is taken, borneol is added to dissolve, the pH is adjusted to 6, the solution is mixed with 5 parts of Tween 80, 2 parts of menthol and 35 parts of water and stirred uniformly until a transparent or translucent microemulsion is formed, 1 part of Carbomer 940 is dispersed in water, and the mixture is allowed to stand for swelling for 12 hours, the microemulsion is slowly added to the gel matrix solution while stirring until a uniform gel is formed, 25 parts of water is added to the gel, the mixture is concentrated to 1 / 3 of the original volume and the alcohol concentration is adjusted to 50%.

[0028] Step (4) Packaging and sterilization: Fill into spray bottles, sterilize by ultraviolet irradiation, and store in a sealed container. Example 3

[0029] Weigh 10 parts of processed Chuanwu, 10 parts of processed Caowu, 15 parts of Carthamus tinctorius, 12 parts of Chuanxiong, 15 parts of Herba Lycopodii, 8 parts of Scorpio, 5 parts of Asarum, 12 parts of Salvia miltiorrhiza, 10 parts of Dioscorea zingiberensis, and 4 parts of Borneol.

[0030] Step (1) raw material pretreatment: processing and reducing the toxicity of processed Chuanwu and processed Caowu, then grinding the above-mentioned traditional Chinese medicines except borneol and medical alcohol into coarse powder, passing through a 40-mesh sieve, and mixing evenly; Step (2) extraction: placing the uniformly mixed drug powder into a sealed container, adding 60% medical alcohol at a drug-liquid weight ratio of 1:8, soaking at room temperature for 10 days, stirring twice a day, filtering after the first extraction, performing a second extraction on the drug residue filtered out from the first extraction, adding 60% medical alcohol at a residue-liquid weight ratio of 1:4, soaking for 5 days, and combining the filtrates obtained from the two extractions; Step (3) concentration and preparation: the filtrate is allowed to stand for 48 hours, the supernatant is taken, borneol is added to dissolve, the pH is adjusted to 5.5-6.5, the solution is mixed with 10 parts of Tween 80, 3 parts of camphor and 50 parts of water and stirred uniformly until a transparent or translucent microemulsion is formed, 0.5-2 parts of hydroxypropyl methylcellulose is dispersed in water, and the mixture is allowed to stand for swelling for 12 hours, the microemulsion is slowly added to the gel matrix solution while stirring until a uniform gel is formed, 40 parts of water is added to the gel, the mixture is concentrated to 1 / 3 of the original volume and the alcohol concentration is adjusted to 55%.

[0031] Step (4) Packaging and sterilization: Fill into spray bottles, sterilize by ultraviolet irradiation, and store in a sealed container.

[0032] The parts of the present invention that are not described in detail are prior art. It is obvious to those skilled in the art that the present invention is not limited to the details of the above-mentioned exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention; therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is limited by the appended claims rather than the above description, and it is intended that all changes within the meaning and scope of the equivalent elements of the claims are included in the present invention.

Claims

1. A Chinese medicine external spray for treating shoulder, neck, waist and leg pain and a preparation method thereof, characterized in that: The components are as follows: 6-10 parts of processed Chuanwu, 6-10 parts of processed Caowu, 10-15 parts of safflower, 10-12 parts of Chuanxiong, 10-15 parts of Shujincao, 5-8 parts of scorpion, 3-5 parts of asarum, 10-12 parts of salvia miltiorrhiza, 8-10 parts of turmeric, and 2-4 parts of borneol; The preparation method comprises the following steps: (1) pretreatment of raw materials: processing and reducing the toxicity of processed Chuanwu and processed Caowu, and then crushing the above-mentioned Chinese medicines except borneol into coarse powder, passing through a 40-mesh sieve, and mixing evenly; Step (2) extraction: placing the uniformly mixed drug powder into a sealed container, adding 60% medical alcohol, with a drug-liquid weight ratio of 1:6-8, soaking at room temperature for 7-10 days, stirring twice a day, filtering after the first extraction, performing a second extraction on the drug residue filtered out from the first extraction, adding 60% medical alcohol, with a residue-liquid weight ratio of 1:3-4, soaking for 5 days, and combining the filtrates obtained from the two extractions; Step (3) Concentration and preparation: let the filtrate stand for 48 hours, take the supernatant, add borneol to dissolve, adjust the pH to 5.5-6.5, concentrate to 1 / 3 of the original volume and adjust the alcohol concentration to 50-55%; Step (4) Packaging and sterilization: Fill into spray bottles and seal for storage.

2. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain as claimed in claim 1 and its preparation method, characterized in that: After the pH value of step (3) is adjusted, the solution is mixed with 5-10 parts by weight of Tween 80, 1-3 parts of oil phase, and 25-50 parts of water, and stirred evenly to form a transparent or translucent microemulsion. 0.5-2 parts of gel matrix are dispersed in water and allowed to swell for 12 hours. The microemulsion is slowly added to the gel matrix solution while stirring until a uniform gel is formed. 25-50 parts of water are added to the gel, concentrated to 1 / 3 of the original volume, and the alcohol concentration is adjusted to 50-55%. The gel is filled into a spray bottle and sealed for storage.

3. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain as claimed in claim 2 and its preparation method, characterized in that: The oil phase is one of menthol or camphor.

4. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain as claimed in claim 2 and its preparation method, characterized in that: The gel matrix is ​​carbomer 940 or hydroxypropyl methylcellulose.

5. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain as claimed in claim 1 and its preparation method, characterized in that: The composition comprises the following components by weight: 8 parts of processed Chuanwu, 8 parts of processed Caowu, 12 parts of safflower, 10 parts of Chuanxiong, 12 parts of Shujincao, 6 parts of scorpion, 4 parts of asarum, 10 parts of salvia miltiorrhiza, 9 parts of turmeric, and 3 parts of borneol.

6. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain as claimed in claim 1 and its preparation method, characterized in that: The composition comprises the following components by weight: 7 parts of processed Chuanwu, 7 parts of processed Caowu, 11 parts of safflower, 12 parts of Chuanxiong, 13 parts of Shujincao, 6 parts of scorpion, 3 parts of asarum, 10 parts of salvia miltiorrhiza, 8 parts of turmeric, and 2 parts of borneol.

7. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain as claimed in claim 1 and its preparation method, characterized in that: The composition comprises the following components by weight: 10 parts of processed Chuanwu, 10 parts of processed Caowu, 15 parts of safflower, 12 parts of Chuanxiong, 15 parts of Shujincao, 8 parts of scorpion, 5 parts of asarum, 12 parts of salvia miltiorrhiza, 10 parts of turmeric, and 4 parts of borneol.

8. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain as claimed in claim 2 and its preparation method, characterized in that: The solution was mixed with 5 parts of Tween 80, 2 parts of menthol and 35 parts of water and stirred evenly to form a transparent or translucent microemulsion. 1 part of Carbomer 940 was dispersed in water and allowed to stand for swelling for 12 hours. The microemulsion was slowly added to the gel matrix solution while stirring until a uniform gel was formed. 25 parts of water was added to the gel, concentrated to 1 / 3 of the original volume and the alcohol concentration was adjusted to 50%.

9. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain as claimed in claim 2 and its preparation method, characterized in that: The solution was mixed with 10 parts of Tween 80, 3 parts of camphor and 50 parts of water and stirred evenly to form a transparent or translucent microemulsion. 0.5-2 parts of hydroxypropyl methylcellulose was dispersed in water and allowed to stand for swelling for 12 hours. The microemulsion was slowly added to the gel matrix solution while stirring until a uniform gel was formed. 40 parts of water was added to the gel, concentrated to 1 / 3 of the original volume and the alcohol concentration was adjusted to 55%.

10. The Chinese medicine external spray for treating shoulder, neck, waist and leg pain and its preparation method as claimed in claim 1 or 2, characterized in that: After filling into the spray bottle, sterilize it with ultraviolet light.