Pressed candy capable of clearing heat from throat and preparation method and application thereof

Abstract

The invention discloses a tablet candy capable of clearing heat from throat and a preparation method and application of the tablet candy, and belongs to the technical field of candy food. The tablet candy is prepared from the following components in parts by weight: 40 to 50 parts of fucoidin, 40 to 45 parts of sorbitol, 2 to 4 parts of gorse powder, 2 to 4 parts of dendrobium officinale powder, 2 to 3 parts of roxburgh rose powder, 0.01 to 0.02 part of lucid ganoderma powder and 1 to 1.5 parts of magnesium stearate. In the eating process, the tablet candy can clear throat, relieve discomfort of the respiratory tract and enhance the immunity of the human body.

Description

Technical Field

[0001] The present application relates to a throat-clearing compressed candy and a preparation method and application thereof, belonging to the technical field of candy foods. Background Art

[0002] Common health problems include low immunity, diverse and long-lasting sequelae of respiratory infections, Helicobacter pylori positivity, insufficient gastrointestinal function, mild anxiety, poor sleep quality, etc. Some people feel uncomfortable after drinking, which causes certain pain and harm to the human body. The alcohol sobering products on the market cannot protect the stomach and intestines while relieving discomfort.

[0003] Some people have more than two of the above health problems at the same time. Such people often need to take multiple products to improve their health status, which is not only expensive and inconvenient to take, but also uncertain whether the effects of the products affect each other. In addition, the use of multiple products will also burden the kidneys and cause new health problems. Therefore, there is an urgent need for a product that can improve multiple health problems at the same time and does not burden the kidneys, so that consumers can take it easily. Summary of the invention

[0004] In order to solve the above problems, a throat-clearing compressed candy is provided. The compressed candy comprises fucoidan, sorbitol, broom powder, dendrobium officinale powder, roxburghii powder, ganoderma lucidum powder and magnesium stearate. When consumed, the compressed candy can enhance human immunity, reduce the risk of respiratory infection, clear the throat, relieve respiratory discomfort, eliminate Helicobacter pylori, enhance gastrointestinal function, relieve anxiety, improve sleep, increase alcohol tolerance and improve various sub-health problems.

[0005] According to one aspect of the present application, a throat-clearing and throat-relief compressed candy is provided, comprising, by weight:

[0006] 40-50 parts of fucoidan, 40-45 parts of sorbitol, 2-4 parts of genus spatholobi powder, 2-4 parts of dendrobium officinale powder, 2-3 parts of roxburghii powder, 0.01-0.02 parts of ganoderma lucidum powder, and 1-1.5 parts of magnesium stearate.

[0007] The fucoidan in candy is a macromolecular polysaccharide composed of fucose and sulfate groups. It can combine with Helicobacter pylori to prevent Helicobacter pylori from adhering to and invading the gastric mucosa, reduce gastric inflammatory response and promote gastric mucosal repair. Fucoidan can regulate intestinal flora, effectively inhibit colon inflammatory response and repair the intestinal barrier. Therefore, it has the function of nourishing the stomach and restoring human digestion, and enhances the killing ability of natural killer cells (NK cells) and T cells. After being injected into the body as a vaccine adjuvant, it can enhance the body's level of antibody production, enhance antiviral immunity, and inhibit the release of inflammatory factors to play an anti-inflammatory role.

[0008] Thread-leaved broom is rich in various flavonoids (such as aspartame, quercetin, luteolin), SOD, and minerals such as calcium, magnesium, and potassium. It acts on organs such as the liver, kidneys, and spleen, and has the effects of calming the central nervous system, lowering the three highs, and enhancing immunity.

[0009] Dendrobium candidum is an important Chinese medicine and is included in the list of medicine and food. It nourishes yin and clears away heat, which can relieve dry mouth, sore throat and other discomfort symptoms caused by high fever; it benefits the stomach and produces body fluid; it protects the liver and improves eyesight, which can enhance vision, relieve symptoms such as sore eyes and pain, and even help prevent the occurrence of cataracts, and strengthen fascia; it also nourishes the kidney and improves the essence, and improves immunity.

[0010] Rosa roxburghii is rich in active substances such as Vc, flavonoids, saponins, polyphenols, polysaccharides, etc. It is suitable for strengthening the stomach and promoting digestion, relieving symptoms such as bloating; it can also promote the metabolism of alcohol and relieve symptoms such as headache, dizziness, nausea, etc. caused by excessive drinking; because it is rich in vitamin C, polyphenols and superoxide dismutase (SOD), it can remove free radicals, delay cell aging, enhance the body's immunity; and it also has anti-atherosclerosis and anti-tumor effects.

[0011] Lingzhi, the best of the traditional Chinese medicines, has the functions of strengthening the body, nourishing and strengthening the body, and can "replenish qi" and "lighten the body", help strengthen the body and prolong life. It has the characteristics of "taking more and taking it for a long time will not hurt people". Lingzhi is rich in polysaccharides, triterpenoids, proteins and trace elements, which can inhibit the production of free radicals, reduce oxidative damage, and delay aging; strengthening the body, it also has the functions of regulating immunity, anti-tumor, regulating blood pressure and blood lipids, and improving cardiovascular health.

[0012] Sorbitol is a refreshing sweetener and excipient with good moisturizing properties. It can maintain the softness of compressed candies, improve the compressed candy structure, and prevent the product from drying out during storage or transportation, thereby extending the shelf life of the product.

[0013] The addition of magnesium stearate improves the fluidity and compressibility of the material, facilitates the molding of the candy, and improves the processing efficiency of the candy.

[0014] Optionally, the weight ratio of the Dendrobium officinale to the Rosa roxburghii powder is (1-1.5):1.

[0015] The above two substances can synergize and maintain the homeostasis of the respiratory system. Chinese medicine believes that if the mother is strong, the child will be strong, and if the child is weak, the mother will be strengthened. The spleen and stomach are the mother of the lung. Dendrobium candidum has the effect of benefiting the stomach and producing body fluid, and Rosa roxburghii has the function of strengthening the spleen and digesting food. The combination of the two can make the spleen and stomach harmonious, and the digestive function is normal, while ensuring the smooth operation of the lung function, improving the immunity of the respiratory system, and making the product better play the role of clearing the throat.

[0016] Optionally, the weight ratio of the fucoidan to the Dendrobium officinale is 1:(0.05-0.08).

[0017] The fucoidan and Dendrobium officinale powder of the present application can work together to play an anti-inflammatory role, relieve sequelae of respiratory infection, and improve symptoms such as dry throat and sore throat. After digestion and absorption, fucoidan can inhibit the release of inflammatory factors in the body and relieve systemic inflammation; Dendrobium officinale nourishes yin and clears heat, which can relieve uncomfortable symptoms such as dry mouth and sore throat caused by high fever. The combination of the two can relieve the inflammatory reaction in the throat, so that the product can play a targeted role in clearing the throat.

[0018] Optionally, the preparation method of the Dendrobium officinale powder is:

[0019] S1: washing and drying the stems of Dendrobium officinale, and then adding Bacillus subtilis and Eurotium cristatum to ferment to obtain a fermented product of Dendrobium officinale;

[0020] S2: placing the fermented product of Dendrobium officinale in water for microfluidization extraction, and filtering to obtain a Dendrobium officinale extract and a Dendrobium officinale filter residue;

[0021] S3: adding aminopeptidase and neutral protease to the Dendrobium officinale extract for enzymolysis, filtering to obtain enzymolysis solution A, and spray-drying the enzymolysis solution A to obtain the Dendrobium officinale powder.

[0022] The preparation method of the Dendrobium officinale powder can maximize the content of Dendrobium officinale polysaccharides and dendrobine in the Dendrobium officinale by first fermenting with Bacillus subtilis and Eurotium cristoloniferum, then performing microfluidization extraction, and finally performing enzymolysis with aminopeptidase and neutral protease, so as to improve the compatibility of the Dendrobium officinale polysaccharides and fucoidan with the Dendrobium officinale, thereby improving the effect of the candy.

[0023] Optionally, the inoculation amount of Bacillus subtilis in step S1 is 1.3%-2.5% of the weight of the stem of Dendrobium officinale, and the number of viable bacteria is 5×10 8 CFU / g-10×10 8 CFU / g, the inoculation amount of the cristatum cristatum is 0.8%-1.2% of the weight of the stem of Dendrobium officinale, and the number of viable bacteria is 5×10 8 CFU / g-10×10 8 CFU / g.

[0024] Optionally, the fermentation temperature of step S1 is 25-30° C., and the fermentation time is 8-10 h.

[0025] Dendrobium officinale contains not only dendrobium polysaccharides and dendrobine, but also other effective ingredients. The cooperation between Bacillus subtilis and Eurotium cristolide can also stimulate the release of other effective ingredients in Dendrobium officinale, thereby improving the effect of the candy. If a single bacterium is used or other bacteria are used to replace Bacillus subtilis and Eurotium cristolide of the present application, the effect of the present application cannot be achieved.

[0026] Optionally, microfluidic extraction is divided into four stages:

[0027] The first stage: extraction pressure is 120-150MPa, time is 0.5-1h;

[0028] The second stage: extraction pressure is 160-200MPa, time is 1-2h;

[0029] The third stage: extraction pressure is 220-240MPa, time is 1-1.5h;

[0030] The fourth stage: extraction pressure is 80-100MPa and time is 0.5-1h.

[0031] The above-mentioned microfluidic extraction process can promote the dissolution of the effective ingredients of Dendrobium officinale and facilitate the stability of the effective ingredients. The extraction pressure is gradually increased from the first stage to the third stage to facilitate the dissolution of Dendrobium officinale polysaccharides, dendrobium alkaloids and other effective ingredients in Dendrobium officinale. The fourth stage as the last stage is conducive to the stability of the dissolved ingredients and is conducive to achieving the best effect.

[0032] Optionally, in step S3, the amount of the aminopeptidase added is 0.2-0.3% by weight of the Dendrobium officinale extract, and the amount of the neutral protease added is 0.3-0.4% by weight of the Dendrobium officinale extract.

[0033] The extract obtained by the above fermentation and microfluidization extraction contains some components that are macromolecules and difficult to be absorbed by the human body. Therefore, under the above fermentation and microfluidization, aminopeptidase and neutral protease are used to enzymolyze the Dendrobium officinale extract to form small molecules that are beneficial to human absorption. However, it has been verified that when the amount of aminopeptidase or neutral protease is too much, it will cause excessive damage to the macromolecules and it is difficult to maintain a good effect. Therefore, the amount of aminopeptidase added in this application should not exceed 0.3% of the weight of the Dendrobium officinale extract, and the amount of neutral protease added should not exceed 0.4% of the weight of the Dendrobium officinale extract.

[0034] Optionally, the enzymolysis temperature of step S3 is 40-50°C, the pH is 7, and the enzymolysis time is 3-4h.

[0035] Optionally, the fucoidan is in powder form, and the purity of the powdered fucoidan is not less than 92%.

[0036] According to another aspect of the present application, there is provided a method for preparing any of the above-mentioned throat-clearing compressed candies, comprising the following steps:

[0037] (1) mixing fucoidan, sorbitol, broom powder, dendrobium officinale powder, roxburghii powder, ganoderma lucidum powder and magnesium stearate to obtain a mixture;

[0038] (2) placing the mixture in a tablet press to tablet the candy.

[0039] Optionally, the specification of the compressed candy is 0.2g-2.0g / piece.

[0040] According to another aspect of the present application, there is provided a use of any of the above-mentioned throat-clearing compressed candies for clearing the throat, removing Helicobacter pylori, nourishing the stomach and restoring digestion, improving sleep, and alleviating discomfort caused by drinking.

[0041] The beneficial effects of this application include but are not limited to:

[0042] 1. The compressed candy of the present application has the effects of clearing the throat, removing Helicobacter pylori, nourishing the stomach and restoring digestion, improving sleep, relieving drinking discomfort, and increasing alcohol tolerance. It can improve multiple sub-health problems at the same time, is easy to carry, and can also enhance human immunity, reduce the risk of respiratory system infection, clear the throat, and relieve respiratory discomfort.

[0043] 2. The compressed candy of the present application is prepared by compounding Dendrobium officinale powder, Rosa roxburghii powder, Ganoderma lucidum powder, Broomflower filamentosa and fucoidan, which can exert the greatest effect under the above-mentioned proportion, improve the immunity of the consumer, have a positive effect on the respiratory tract, and thus have the effect of clearing the throat.

[0044] 3. The compressed candy of the present application uses a special process to process the Dendrobium officinale, which can increase the release of effective ingredients such as polysaccharides and dendrobine in the Dendrobium officinale, thereby achieving the best effect. DETAILED DESCRIPTION

[0045] The present application is described in detail below with reference to embodiments, but the present application is not limited to these embodiments.

[0046] Unless otherwise specified, the raw materials in the examples of this application were purchased through commercial channels.

[0047] In the following examples and comparative examples, the fucoidan was purchased from Qingdao Mingyue Seaweed Group Co., Ltd., and the purity of the fucoidan was 92%. Sorbitol was purchased from Qingdao Mingyue Seaweed Group Co., Ltd., genkia striata pollen was purchased from Qingdao Huibaicui Biotechnology Co., Ltd., roxburghii powder was purchased from Xi'an Shouhe Biotechnology Co., Ltd., ganoderma lucidum powder was purchased from Shaanxi Ciyuan Biotechnology Co., Ltd., and magnesium stearate was purchased from Huzhou Linghu Xinwang Chemical Co., Ltd.

[0048] Example 1

[0049] This embodiment involves processing the stems of Dendrobium officinale to obtain Dendrobium officinale powder for preparing candy. Dendrobium officinale 1#-8# are prepared according to the following preparation method:

[0050] Dendrobium candidum 1#

[0051] S1: washing and drying the stems of Dendrobium officinale, and then drying them at 80° C. for 24 hours to obtain a dried product;

[0052] S2: The dried product is placed in 10 times the amount of water for microfluidization extraction, and filtered to obtain the Dendrobium officinale extract and Dendrobium officinale residue. The microfluidization extraction is divided into four stages:

[0053] The first stage: extraction pressure is 120MPa and time is 1h;

[0054] The second stage: extraction pressure is 160MPa and time is 2h;

[0055] The third stage: extraction pressure is 240MPa and time is 1h;

[0056] The fourth stage: extraction pressure is 80MPa and the time is 1h;

[0057] The Dendrobium officinale extract was spray-dried to obtain Dendrobium officinale 1#.

[0058] Dendrobium candidum 2#

[0059] S1: Wash and dry the stems of Dendrobium officinale, then add Bacillus subtilis and Eurotium cristatum to ferment at 25°C for 10 h to obtain the fermented product of Dendrobium officinale. The inoculation amount of Bacillus subtilis is 1.3% of the weight of the stems of Dendrobium officinale, and the number of viable bacteria is 10×10 8 CFU / g, the inoculation amount of the cristatum was 0.8% of the weight of the stem of Dendrobium officinale, and the number of viable bacteria was 10×10 8 CFU / g;

[0060] S2: The fermented material of Dendrobium officinale is placed in 10 times water for microfluidization extraction, and the Dendrobium officinale extract and the Dendrobium officinale residue are obtained by filtration. The microfluidization extraction is divided into four stages:

[0061] The first stage: the extraction pressure is 120 MPa and the time is 1 h;

[0062] The second stage: the extraction pressure is 160 MPa and the time is 2 h;

[0063] The third stage: the extraction pressure is 240 MPa and the time is 1 h;

[0064] The fourth stage: the extraction pressure is 80 MPa and the time is 1 h;

[0065] S3: Add 0.2% aminopeptidase and 0.3% neutral protease based on the weight of the Dendrobium officinale extract, enzymatically hydrolyze at 40 °C and pH 7 for 4 h, filter to obtain the enzymolysis solution A, and spray-dry the enzymolysis solution A to obtain the Dendrobium officinale 2#.

[0066] Dendrobium officinale 3#

[0067] S1: Wash and dry the Dendrobium officinale stems, then add Bacillus subtilis and Eurotium cristatum, ferment at 30 °C for 8 h to obtain the Dendrobium officinale fermentation product. The inoculation amount of Bacillus subtilis is 2.5% of the weight of the Dendrobium officinale stems, and the viable count is 5×10 8 CFU / g, and the inoculation amount of Eurotium cristatum is 1.2% of the weight of the Dendrobium officinale stems, and the viable count is 5×10 8 CFU / g;

[0068] S2: Place the Dendrobium officinale fermentation product in 20 times the amount of water for microfluidic extraction, filter to obtain the Dendrobium officinale extract and the Dendrobium officinale filter residue. The microfluidic extraction is divided into four stages:

[0069] The first stage: the extraction pressure is 150 MPa and the time is 0.5 h;

[0070] The second stage: the extraction pressure is 200 MPa and the time is 1 h;

[0071] The third stage: the extraction pressure is 220 MPa and the time is 1.5 h;

[0072] The fourth stage: the extraction pressure is 100 MPa and the time is 0.5 h;

[0073] S3: Add 0.3% aminopeptidase and 0.4% neutral protease based on the weight of the Dendrobium officinale extract, enzymatically hydrolyze at 50 °C and pH 7 for 3 h, filter to obtain the enzymolysis solution A, and spray-dry the enzymolysis solution A to obtain the Dendrobium officinale 3#.

[0074] Dendrobium officinale 4#

[0075] The difference from Dendrobium officinale 3# is that Eurotium cristatum is not added in step S1, and the rest is the same as Dendrobium officinale 3#.

[0076] Dendrobium candidum 5#

[0077] The difference from Dendrobium officinale 3# is that Bacillus subtilis is not added in step S1, and the rest is the same as Dendrobium officinale 3#.

[0078] Dendrobium candidum 6#

[0079] The difference from Dendrobium officinale 3# is that the extraction pressure used in step S2 is 200 MPa for extraction for 3.5 hours, and the rest is the same as Dendrobium officinale 3#.

[0080] Dendrobium candidum 7#

[0081] The difference from Dendrobium officinale 3# is that the amount of aminopeptidase added in step S3 is 0.5% of the weight of the Dendrobium officinale extract, and the rest is the same as Dendrobium officinale 3#.

[0082] Dendrobium candidum 8#

[0083] The difference from Dendrobium officinale 3# is that the amount of the central protease added in step S3 is 0.5% of the weight of the Dendrobium officinale extract, and the rest is the same as Dendrobium officinale 3#.

[0084] Test Example 1

[0085] The contents of Dendrobium officinale polysaccharide and dendrobine were determined in the Dendrobium officinale extract in Dendrobium officinale 1# and the Dendrobium officinale enzymatic hydrolyzate in Dendrobium officinale 2#-8#, and the yields of Dendrobium officinale polysaccharide and dendrobine were calculated. The test results are shown in Table 1 below.

[0086] Table 1 Yields of Dendrobium officinale polysaccharide and Dendrobium officinale alkaloids

[0087] Serial number Dendrobium officinale polysaccharide yield (%) Dendrobium officinale alkaloid yield (%) Dendrobium candidum 1# 28.1 0.0345 Dendrobium candidum 2# 38.3 0.0385 Dendrobium candidum 3# 38.5 0.0394 Dendrobium candidum 4# 29.5 0.0386 Dendrobium candidum 5# 31.9 0.0348 Dendrobium candidum 6# 37.1 0.0372 Dendrobium candidum 7# 34.0 0.0359 Dendrobium candidum 8# 36.1 0.0361

[0088] Example 2

[0089] This embodiment relates to a throat-clearing and throat-relief compressed candy and a preparation method thereof, comprising the following steps:

[0090] (1) mixing 40-50 parts of fucoidan, 40-45 parts of sorbitol, 2-4 parts of genus spatholobi powder, 2-4 parts of dendrobium officinale powder, 2-3 parts of roxburghii powder, 0.01-0.02 parts of ganoderma lucidum powder and 1-1.5 parts of magnesium stearate to obtain a mixture;

[0091] (2) placing the mixture in a tablet press to obtain the compressed candy, wherein the specification of the compressed candy is 0.8 g / piece.

[0092] According to the above preparation method, the following candies 1#-9# were prepared, wherein the Dendrobium officinale powder used was the Dendrobium officinale 1#-8# prepared in Example 1, and the specific differences are shown in Table 2 below.

[0093] Table 2 Candy ratio table

[0094]

[0095] Test Example 1: Clearing the Throat

[0096] The candies of the above-mentioned embodiments were tested for throat clearing and relieving throat, specifically: volunteers with sequelae of respiratory tract infection or chronic pharyngitis were recruited, aged 18-36 years old, half male and half female, and randomly divided into groups, with 30-40 people in each group. Each group of volunteers took this product 1 tablet / time, 3 times / day, for 15 days. Before the start and after 15 days, the throat discomfort symptom scoring questionnaire in Table 3 was used to score once each, and Δ throat discomfort symptom score = initial throat discomfort symptom score - ending throat discomfort symptom score was calculated. When the throat discomfort symptom score is ≥10, it is considered that this product has played a role in clearing the throat and relieving throat. The test results are shown in Table 4 below.

[0097] Table 3 Throat discomfort symptom scoring questionnaire

[0098]

[0099] Scoring instructions:

[0100] Mild (1 point): Symptoms occur occasionally and have little impact on daily life.

[0101] Moderate (2 points): Symptoms occur frequently and have a certain impact on daily life.

[0102] Severe (3 points): Symptoms are persistent and severe, with a significant impact on daily life.

[0103] Table 4 Throat discomfort symptom scoring data

[0104]

[0105] Test Example 2: Elimination of Helicobacter pylori

[0106] The candies of the above examples were tested for the elimination of Helicobacter pylori, specifically: 14 Volunteers who were positive for C-urea breath test, aged 35-60 years old, half male and half female, were randomly divided into groups, with 40-48 people in each group. Each group of volunteers took 3 tablets of this product on an empty stomach before going to bed every day for 30 days. After 30 days, Helicobacter pylori 14 C-urea breath test DPM value, calculate each person's ΔDPM value = initial DPM value - end DPM value. When the ΔDPM value is ≥ 200, it is considered that this product has played a role in clearing Helicobacter pylori. The test results are shown in Table 5 below.

[0107] Table 5 Helicobacter pylori14 C-urea breath test DPM value

[0108]

[0109]

[0110] Test Example 3: Nourishing the Stomach and Restoring Digestion

[0111] The candies of the above examples were tested for their stomach-nourishing and digestion-restoring functions, specifically: 14 Volunteers who were positive for C-urea breath test were screened for obvious discomfort symptoms such as stomach pain, loss of appetite, abdominal distension after eating, heartburn or burning sensation, acid reflux, nausea and vomiting, belching, bitter mouth, and bad breath. They were aged 35-60 years old, half male and half female, and randomly divided into 25-30 people in each group. Each group of volunteers took 3 tablets of this product on an empty stomach before going to bed every day for 30 days. Before the start and after 30 days, the physical feelings were scored once according to the stomach clinical symptom scoring questionnaire in Table 6, and the Δ stomach clinical symptom score for each person was calculated = the initial stomach clinical symptom score - the end stomach clinical symptom score. When the Δ stomach clinical symptom score is ≥12, it is believed that this product has played a role in nourishing the stomach and restoring digestive function. The test results are shown in Table 7 below.

[0112] Table 6 Gastric clinical symptom scoring questionnaire

[0113]

[0114]

[0115] Table 7 Gastric clinical symptom scoring questionnaire data

[0116]

[0117] Test Example 4: Improve Sleep

[0118] The candies of the above embodiment were tested for improving sleep, specifically: volunteers with unsatisfactory sleep quality were recruited, and those with obvious symptoms such as difficulty falling asleep, short sleep time, easy awakening, going to the toilet at night, dyspnea, high snoring, and lack of energy during the day were screened. The age was 20-60 years old, half male and half female, and randomly divided into groups, with 36 people in each group. Each group of volunteers consumed 3 pieces of this product every day for 30 days. Before the start and after 30 days, the Pittsburgh Sleep Quality Index (PSQI) scale in Table 8 was scored once each, and the scores were calculated according to the method of Table 9 to obtain PSQI = A + B + C + D + E + F + G, and each person's Δ sleep quality score = initial sleep quality score - end sleep quality score was calculated. When the Δ sleep quality score is ≥5, it is considered that this product has played a role in improving sleep. The test results are shown in Table 10 below.

[0119] Table 8 Pittsburgh Sleep Quality Index (PSQI) Scale

[0120]

[0121] Table 9 Scoring method

[0122]

[0123] The calculation method of sleep efficiency in Table 7 is:

[0124]

[0125] The total score of PSQI = A+B+C+D+E+F+G. 0-5 points represent very good sleep quality, 6-10 points represent good sleep quality, 11-15 points represent average sleep quality, and 16-21 points represent very poor sleep quality.

[0126] Table 10 Pittsburgh Sleep Quality Index (PSQI) questionnaire score data

[0127]

[0128] Test Example 5: Relieve Discomfort from Drinking

[0129] The candies of the above embodiment were tested for relieving the discomfort of drinking, specifically: volunteers with daily drinking needs were recruited, and those with obvious discomfort symptoms such as headache, nausea and vomiting, uncoordinated movements, decreased vision, and emotional instability were screened. The age was 20-55 years old, and the gender composition ratio between each group was the same. They were randomly divided into 30 groups. Each group of volunteers first scored the previous experience according to the common drinking discomfort symptom scoring questionnaire in Table 11 to obtain the initial drinking discomfort score; thereafter, according to their own drinking opportunities, they took the test at an appropriate time and consumed 3 pieces of this product within 30 minutes before drinking. After returning to normal, the discomfort after drinking was scored immediately. Repeat the test 3 times to obtain the average test score. Calculate Δ drinking discomfort score = initial drinking discomfort score - test average score. When Δ drinking discomfort score ≥ 5, it is considered that this product has played a role in relieving the discomfort of drinking. The test results are shown in Table 12 below.

[0130] Table 11 Common symptoms of alcohol discomfort score questionnaire

[0131]

[0132]

[0133] Table 12 Scoring data of questionnaire on relieving discomfort caused by drinking

[0134]

[0135]

[0136] According to the above test results, the present invention provides a compressed candy for clearing the throat, which can clear the throat, relieve respiratory discomfort symptoms, and at the same time eliminate Helicobacter pylori, enhance gastrointestinal function, improve sleep quality, and increase alcohol tolerance through the synergistic enhancement of the scientific ratio of fucoidan, broom flower, dendrobium officinale, roxburghii powder and ganoderma lucidum powder. It has a high efficiency in all functional directions, achieving the purpose of improving multiple sub-health problems with one product.

[0137] The above is only the embodiment of the present application, and the protection scope of the present application is not limited by these specific embodiments, but is determined by the claims of the present application. For those skilled in the art, the present application can have various changes and variations. Any modification, equivalent replacement, improvement, etc. made within the technical ideas and principles of the present application should be included in the protection scope of the present application.

Claims

1. A throat-clearing and throat-relief compressed candy, characterized in that: The parts by weight include: 40-50 parts of fucoidan, 40-45 parts of sorbitol, 2-4 parts of genus spatholobi powder, 2-4 parts of dendrobium officinale powder, 2-3 parts of roxburghii powder, 0.01-0.02 parts of ganoderma lucidum powder, and 1-1.5 parts of magnesium stearate.

2. The throat-clearing compressed candy according to claim 1, characterized in that: The weight ratio of the Dendrobium officinale powder to the Rosa roxburghii powder is (1-1.5):

1.

3. The throat-clearing and throat-relief compressed candy according to claim 1, characterized in that: The weight ratio of the fucoidan to the Dendrobium officinale powder is 1:(0.05-0.08).

4. The throat-clearing and throat-relief compressed candy according to claim 1, characterized in that: The preparation method of the Dendrobium officinale powder is: S1: washing and drying the stems of Dendrobium officinale, and then adding Bacillus subtilis and Eurotium cristatum to ferment to obtain a fermented product of Dendrobium officinale; S2: placing the fermented Dendrobium officinale in 10-20 times water for microfluidization extraction, and filtering to obtain a Dendrobium officinale extract and a Dendrobium officinale filter residue; S3: adding aminopeptidase and neutral protease to the Dendrobium officinale extract for enzymolysis, filtering to obtain enzymolysis solution A, and spray-drying the enzymolysis solution A to obtain the Dendrobium officinale powder.

5. The throat-clearing compressed candy according to claim 4, characterized in that: The inoculation amount of Bacillus subtilis in step S1 is 1.3%-2.5% of the weight of the stem of Dendrobium officinale, and the number of viable bacteria is 5×10 8 CFU / g-10×10 8 CFU / g, the inoculation amount of the cristatum cristatum is 0.8%-1.2% of the weight of the stem of Dendrobium officinale, and the number of viable bacteria is 5×10 8 CFU / g-10×10 8 CFU / g.

6. The throat-clearing compressed candy according to claim 4, characterized in that: The microfluidic extraction in step S2 is divided into four stages: The first stage: extraction pressure is 120-150MPa, time is 0.5-1h; The second stage: extraction pressure is 160-200MPa, time is 1-2h; The third stage: extraction pressure is 220-240MPa, time is 1-1.5h; The fourth stage: extraction pressure is 80-100MPa and time is 0.5-1h.

7. The throat-clearing and throat-relief compressed candy according to claim 1, characterized in that: In step S3, the amount of aminopeptidase added is 0.2-0.3% of the weight of the Dendrobium officinale extract, and the amount of neutral protease added is 0.3-0.4% of the weight of the Dendrobium officinale extract.

8. The throat-clearing compressed candy according to claim 1, characterized in that: The fucoidan is in powder form, and the purity of the powdered fucoidan is not less than 92%.

9. The method for preparing the throat-clearing and throat-relief compressed candy according to any one of claims 1 to 8, characterized in that: The steps include: (1) mixing fucoidan, sorbitol, broom powder, dendrobium officinale powder, roxburghii powder, ganoderma lucidum powder and magnesium stearate to obtain a mixture; (2) placing the mixture in a tablet press to tablet the candy.

10. Use of the throat-clearing compressed candy according to any one of claims 1 to 8 in clearing the throat, removing Helicobacter pylori, nourishing the stomach and restoring digestion, improving sleep, and relieving discomfort caused by drinking.

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