Method for quickly acquiring physical information of human life

Abstract

The invention belongs to the technical field of biophysical and biomedical examination, and particularly relates to a human life physical information quick acquisition method, which comprises the following steps of: after a sample is kept in a resting state for a period of time, utilizing a parallel plate capacitance sensor in a parallel mode; measuring changes of capacitance, resistance, impedance, capacitive reactance and inductive reactance of an earlobe part of a human body in a resting state under different tiny pressures, constructing a model of the capacitance, resistance, impedance, capacitive reactance and inductive reactance changing along with the pressures, and obtaining earlobe resting electrical parameters; according to the model parameters and the earlobe resting electrical parameters, calculating the energy conversion capability, intracellular moisture and nutrient transportation capability, intracellular dielectric substance transfer capability and cell metabolism capability of earlobe cells; and forming a human body life physical information detection report of the to-be-detected person according to the obtained data list. Instant electrical parameters of earlobes of human body information are utilized, and biophysical indexes are used for representing human body energy conversion capability, material transportation and transformation capability and cell metabolism capability, so that the physiological function of a human body is objectively reflected.

Description

Technical Field

[0001] The invention belongs to the technical field of biophysics and biomedical testing, and in particular relates to a method for quickly acquiring human body biophysical information. Background Art

[0002] The electrical components on the cells absorb energy for energy storage and conversion, causing changes in material metabolism and energy metabolism. Measuring the electrical behavior and biophysical characteristics of cells can characterize the metabolic status and physiological functions of cells. For the heterotrophic human body, various complex life activities and physiological functions are coordinated and carried out by eight major systems including the motor system, nervous system, endocrine system, circulatory system, respiratory system, digestive system, urinary system, and reproductive system. The cell structure and function between organs are diverse, making it extremely difficult to select an organ or organ to obtain the energy storage and conversion information of electrical components in cells online without loss, and then characterize the overall physiological function, viscera and organ functions, and health status of the human body. Summary of the invention

[0003] The technical problem to be solved by the present invention is that it is difficult to quickly and non-destructively obtain the electrical behavior and biophysical characteristics of human cells online to characterize the energy conversion, material transportation and cell metabolism capabilities of the human body.

[0004] To this end, the present invention provides a method for quickly acquiring human body life physical information.

[0005] The technical solution adopted by the present invention to solve the technical problem is:

[0006] A method for quickly acquiring human body life physical information comprises the following steps:

[0007] Step 1: After the sample to be tested is kept in a resting state for a period of time, a parallel plate capacitance sensor is used in a parallel mode to measure the changes in capacitance, resistance, impedance, capacitive reactance and inductive reactance of the earlobe of the human body in a resting state under different small pressures, and a model of capacitance, resistance, impedance, capacitive reactance and inductive reactance changing with pressure is constructed to obtain the resting electrical parameters of the earlobe;

[0008] Step 2: Calculate the energy conversion capacity, intracellular water and nutrient transport capacity, intracellular dielectric substance transfer capacity and cell metabolism capacity of earlobe cells based on the model parameters and earlobe resting electrical parameters;

[0009] Step three, the data list obtained in the above steps is used to form a test report on the life and physical information of the human body of the subject.

[0010] Further, in step 2, the earlobe resting electrical parameters include earlobe thickness d, earlobe resting capacitance ICP, earlobe resting resistance IR, earlobe resting capacitive reactance IXc, earlobe resting inductive reactance IXl, earlobe resting impedance IZ, earlobe cell unit resting capacitance ICP U 、Earlobe cell unit resting resistance IR U , resting capacitance ICP of earlobe cells U , resting resistance of earlobe cell unit IXl U and the cell unit resting impedance IZ U .

[0011] Furthermore, the earlobe resting resistance IR is calculated as follows: IR = y 1 +k 1 , where y 1 and k 1 is the parameter of the model of earlobe resistance changing with pressure, and the earlobe cell unit resting resistance IR U The calculation method is: IR U =IR×d; the calculation method of the earlobe resting impedance IZ is: IZ=y 2 +k 2 , where y 2 and k 2 is the parameter of the model of earlobe impedance variation with pressure, and the earlobe cell unit resting impedance IZ U The calculation method of IZ is: U =IZ×d; the calculation method of the earlobe resting capacitive reactance IXc is: IXc=y 3 +k 3 , where y 3 and k 3 is the parameter of the model of earlobe capacitance changing with pressure, and the earlobe cell unit resting capacitance IXc U The calculation method is: IXc U =IXc×d; the calculation method of the earlobe resting inductive reactance IXl is: IXl=y 4 +k 4 , where y 4 and k 4 is the parameter of the model of earlobe reactance changing with pressure, and the resting reactance of earlobe cell unit is IXl U The calculation method is: IXl U = IXl × d; the method of calculating the earlobe resting capacitance ICP is: Where f is the test frequency, the earlobe cell unit resting capacitance ICP U The calculation method is: ICP U =ICP / d, the calculation method of earlobe thickness d is: Wherein U is the test voltage, and h is the parameter of the model of earlobe cell capacitance changing with pressure.

[0012] Furthermore, in step 2, the intracellular water and nutrient transportation capacity includes the intracellular water transportation capacity of earlobe cells and the intracellular nutrient transportation capacity of earlobe cells.

[0013] Furthermore, the intracellular water transport capacity of the earlobe cells includes the intracellular water holding capacity IWHC, the intracellular water transport efficiency IWTTE, the intracellular water holding time IWHT and the intracellular water transport rate IWTTR; the method for calculating the intracellular water holding capacity IWHC based on the earlobe resting capacitance ICP is: The method for calculating the intracellular water transport efficiency IWTTE based on the earlobe thickness d and the intracellular water holding capacity IWHC is: According to the earlobe resting capacitance ICP and earlobe resting impedance IZ, the calculation formula for the intracellular water holding time IWHT is: IWHT = ICP × IZ; according to the intracellular water holding capacity IWHC and the intracellular water holding time IWHT, the calculation formula for the intracellular water transport rate IWTTR is:

[0014] Furthermore, the intracellular nutrient transport capacity of the earlobe cells includes the intracellular nutrient transport rate INTTR, the intracellular nutrient transport efficiency INTTE, the active transport unit flow rate UATTF, the intracellular nutrient active transport capacity NATTC, the intracellular nutrient transport unit flow rate UNTTF, the intracellular nutrient transport capacity NTTC, the intracellular nutrient passive transport unit flow rate UPTTF, the intracellular nutrient passive transport capacity NPTTC, and the intracellular active / passive transport capacity ratio RAP; the calculation formula of the intracellular nutrient transport efficiency INTTE is: The calculation formula of the intracellular active transport unit flow UATTF is: The calculation formula of the intracellular nutrient active transport capacity NATTC is: NATTC = UATTF × INTTR; the intracellular nutrient transport unit flow UNTTF can be expressed as: The calculation formula of the intracellular nutrient transport capacity NTTC is: NTTC = UNTTF × INTTR; the calculation formula of the intracellular passive transport unit flow UPTTF is: UPTTF = UNTTF - UATTF; the calculation formula of the intracellular nutrient passive transport capacity NPTTC is: NPTTC = NTTC - NATTC; the calculation formula of the intracellular active / passive transport capacity ratio RAP is:

[0015] Furthermore, the intracellular dielectric substance transfer capacity includes the number of intracellular dielectric substances transferred, the transport force and transport resistance of various substances, the transport capacity of various substances, and the RTTC of the transport of capacitive / sensitive substances. C-L ; Wherein, the transfer number of various dielectric substances in the cell includes the transfer number of dielectric substances Kn of the response resistance R 、Dielectric material transfer number Kn corresponding to capacitive reactance XC , Dielectric material transfer number Kn of response inductive reactance XL And the dielectric material transfer number Kn of the response impedance Z The conduction force and conduction resistance of various substances include the conduction force of resistive substances ICF R , resistive material conduction resistance ICR R , Capacitive Material Conductivity ICF C , Capacitive material conduction resistance ICR C , Inductive Material Conductivity ICF L , Inductive material conduction resistance ICR L , total dielectric conductivity ICF Z and total dielectric conductivity resistance ICR Z ; The transport capacity of various substances includes the transport capacity of resistive substances TTC R , TTC C , sensory material transport capacity TTC L Total dielectric transport capacity TTC Z The dielectric material transfer number Kn of the response resistor R The calculation method of Kn is: R =lnk 1 -lny 1 The dielectric material transfer number Kn of the response capacitive reactance XC The calculation method of Kn is: XC =lnk 3 -lny 3 The dielectric material transfer number Kn of the response inductive reactance XL The calculation method of Kn is: XL =lnk 4 -lny 4 The dielectric material transfer number Kn of the response impedance Z The calculation method of Kn is: Z =lnk 2 -lny 2 The resistive material conduction force ICF R The calculation method is: The resistive material conduction resistance ICR R The calculation method is: ICR R =-b 1 k1 , the capacitive material conduction force ICF C The calculation method is: The capacitive material conduction resistance ICR C The calculation method is: ICR C =-b 3 k 3 , the inductive material conduction force ICF L The calculation method is: The inductive material conduction resistance ICR L The calculation method is: ICR L =-b 4 k 4 The total dielectric conductivity ICF Z The calculation method is: The total dielectric material conductance resistance ICR Z The calculation method is: ICR Z =-b 2 k 2 ; The resistive material transport capacity TTC R The calculation method is: TTC R =ICF R / Kn R ; The transport capacity of the capacitive substance TTC C The calculation method is: TTC C =ICF C / Kn XC ; The transport capacity of the sensory substance TTC L The calculation method is: TTC L =ICF L / Kn XL ; The total dielectric transport capacity TTC Z The calculation method is: TTC Z =ICF Z / Kn Z ; The transport ratio of the capacitive substance to the perceptual substance RTTC C-L The calculation formula is: RTTC C-L =TTC C / TTC L .

[0016] Furthermore, the energy conversion capacity of the earlobe cells includes the unit endogenous energy ΔG based on resistance. R-U and endogenous energy ΔG based on resistance R , Unit endogenous energy ΔG based on capacitive reactance Xc-U and endogenous energy ΔG based on capacitive reactance Xc , Unit endogenous energy ΔG based on inductive reactance Xl-U and endogenous energy ΔG based on inductive reactanceXl , Unit endogenous energy ΔG based on impedance Z-U and the endogenous energy ΔG based on impedance Z , average unit endogenous energy ΔG U , Capacitive reactance endogenous energy / Inductive reactance endogenous energy RG Xc-xl

[0017] Furthermore, the unit endogenous energy ΔG based on resistance R-U The calculation method is: The endogenous energy ΔG based on resistance R The calculation method is: ΔG R =ΔG R-U ×d; the unit endogenous energy ΔG based on impedance Z-U The calculation method is: The endogenous energy ΔG based on impedance Z The calculation method is: ΔG Z =ΔG Z-U ×d; the unit endogenous energy ΔG based on capacitive reactance Xc-U The calculation method is: The endogenous energy ΔG based on capacitive reactance Xc The calculation method is: ΔG Xc =ΔG Xc-U ×d; the unit endogenous energy ΔG based on inductive reactance Xl-U The calculation method is: The endogenous energy ΔG based on inductive reactance Xl The calculation method is: ΔG Xl =ΔG Xl-U ×d; the average unit endogenous energy ΔG U The calculation method is: The capacitive reactance endogenous energy / inductive reactance endogenous energy RG Xc-xl The calculation method of RG is: Xc-xl＝ ΔG Xc-U / ΔG Xl-U .

[0018] Furthermore, the cell metabolic capacity includes earlobe cell metabolic rate MR, earlobe cell metabolic flux MF, cell metabolic intensity MS and earlobe cell relative metabolic activity MA.

[0019] Furthermore, the method for obtaining the earlobe cell metabolic rate MR is: MR=INTTR×NATTC; the method for obtaining the earlobe cell metabolic flux MF is: The method for obtaining the cell metabolic intensity MS is: MS=ln[MF]; the method for obtaining the earlobe cell relative metabolic activity MA is:

[0020] The beneficial effect of the present invention is that the present application uses earlobe cells as a window, based on the fact that the earlobe is composed of fat and fibrous tissue, has no cartilage, good homogeneity, no cell wall, heterotrophy and unique composition characteristics, so that we can not only obtain electrical parameters such as the average resting capacitance (resistance, inductance, capacitance, impedance) of earlobe cells, but also obtain the material transportation capacity based on heterotrophy.

[0021] Thus, the present application applies a small energy variable to the earlobe cells, obtains the electrical parameters such as earlobe capacitance, resistance, inductance, capacitive reactance, impedance, etc. of the human body in a resting state under the action of a high-frequency low-voltage electric field online, constructs a physical model between electrical parameters and pressure based on the Gibbs free energy equation and the Nernst equation, constructs an earlobe cell thermodynamic model based on the physical model between electrical parameters and pressure and electrical principles, obtains the energy conversion capacity, intracellular water and nutrient transportation capacity, intracellular dielectric material transfer capacity and cell metabolism capacity of the earlobe cells based on the earlobe cell thermodynamic model and biophysical principles, and provides essential first-hand data for the diagnosis of physiological functions, viscera and organ functions and health status. Among them, by measuring the electrical parameters of the earlobe that can reflect human information, and analyzing the electrical behavior and biophysical characteristics of the earlobe cells based on the Gibbs free energy equation and the Nernst equation, the physiological functions of the human body (especially the material transportation capacity based on heterotrophy), viscera and organ functions and health status can be truly and objectively reflected. Provide basic data and reference for disease diagnosis, health assessment and selection of personnel in special industries (such as athletes, astronauts, etc.).

[0022] The present application makes a groundbreaking proposal to utilize electrical parameters such as earlobe capacitance, resistance, inductance, capacitive reactance, and impedance to analyze the electrical behavior and biophysical characteristics of the earlobe based on the Gibbs free energy equation and the Nernst equation, which can well describe the process of energy conversion in different forms and the conversion of system internal energy into chemical energy, to characterize the energy conversion, material transportation, and metabolic characteristics of earlobe cells, thereby achieving real-time quantification of human physiological functions, viscera and organ functions, and health status, building a bridge between traditional Chinese medicine and Western medicine, overcoming the defect of traditional Chinese medicine in being unable to quantify energy conversion, material transportation, and metabolism, and rapidly and completely quantifying human cell energy conversion, material transportation, and metabolic capacity online, and rapidly and completely forming a human physical examination report with biophysical indicators, without pain, harm, or stimulation, and without the need for blood drawing. The physical examination report truly and objectively reflects human physiological functions, viscera and organ functions, and health status, and has the advantages of being simple, fast, time-saving, small workload, wide applicability, and simple operation.

[0023] This application not only obtains the electrical parameters of human cells such as resting capacitance, resting resistance, resting inductance, resting capacitance, and resting impedance online for the first time, but also obtains the transportation and transformation capabilities of various substances at the same time for the first time, overcoming the defects of Western medicine that it is difficult to detect resting electrical parameters of cells other than resting potential of cells and the inability of traditional Chinese medicine to quantify the transportation and transformation capabilities of various substances.

[0024] This method fills the gap in using biophysical indicators to characterize the human body's energy conversion ability, material transportation ability and cell metabolism ability. It uses the real-time electrical parameters of the earlobe that can reflect human body information to analyze the electrical behavior and biophysical characteristics of earlobe cells based on the Gibbs free energy equation and the Nernst equation that can well describe the process of energy conversion in different forms and the conversion of system energy into chemical energy. It truly and objectively reflects the human body's physiological functions, internal organs and organ functions, and health status. DETAILED DESCRIPTION

[0025] A method for quickly acquiring human body life physical information comprises the following steps:

[0026] Step 1: Online parameter acquisition

[0027] Traditional Chinese medicine theory and modern medical testing practice tell us that the ear is a window of human information and an important external appearance of human organs. It can reflect the information of the organs and meridians of the whole body. The earlobe is a part of the auricle, located below the helix and at the lowest part of the auricle. It is composed of fat and fibrous tissue, without cartilage and complex blood vessels to interfere with the measurement of real-time electrical parameters. It is a common site for acupuncture and clinical blood sampling. The earlobe cells are composed of adipose tissue and connective tissue. Adipose tissue is composed of fat cells in the fat depot containing triglycerides. Connective tissue is composed of cells and a large amount of intercellular matrix. The intercellular matrix of connective tissue includes liquid, colloidal or solid matrix, filamentous fibers and tissue fluid that is constantly circulated and renewed. Therefore, the real-time electrical parameters of the earlobe can truly and objectively reflect the overall physiological function of the human body.

[0028] Before the measurement, the sample to be tested was kept in a resting state for 20 minutes. Then, the parallel plate capacitance sensor was gently clamped in the center of the earlobe of the subject to be tested. The measuring voltage, frequency and different pressure levels were set, and the LCR meter was started in parallel mode to measure the changes in capacitance, resistance, impedance, capacitive reactance and inductive reactance of the earlobe part of the human body in a resting state under different small pressures. According to the Gibbs free energy equation and the Nernst equation, a model of capacitance, resistance, impedance, capacitive reactance and inductive reactance changing with pressure was constructed. The parameters of these models were used to obtain the earlobe resting electrical parameters including earlobe thickness, earlobe resting capacitance, earlobe resting resistance, earlobe resting capacitive reactance, earlobe resting inductive reactance, earlobe resting impedance, earlobe cell unit resting capacitance, earlobe cell unit resting resistance, earlobe cell unit resting capacitive reactance, earlobe cell unit resting inductive reactance and cell unit resting impedance.

[0029] Specifically, the calculation formula for earlobe capacitance is: Where Xc is the earlobe capacitive reactance, Cp is the earlobe capacitance, f is the test frequency, and π is the ratio of pi, which is equal to 3.1416.

[0030] Since the earlobe resistance, impedance and capacitance are measured in parallel mode, the calculation formula of the earlobe inductive reactance is: Where Xl is the earlobe inductive reactance, Xc is the earlobe capacitive reactance, Z is the earlobe impedance, and R is the earlobe resistance.

[0031] The Gibbs free energy equation is expressed as ΔG = ΔH + PV, and the energy formula of the capacitor is expressed as W is the energy of the capacitor, which is equal to the work converted from Gibbs free energy ΔG, that is, W=ΔG; ΔH is the internal energy of the system (the earlobe composed of cells), P is the pressure on the earlobe cells, V is the volume of the earlobe cells, U is the test voltage, and Cp is the capacitance of the earlobe cells.

[0032] S1.1 Model of earlobe cell capacitance changing with pressure

[0033] Earlobe cell capacitance C p The equation for the change of pressure F is:

[0034]

[0035] Where ΔH is the endogenous energy of earlobe cells, U is the test voltage, and d is the thickness of earlobe. Formula (1) can be transformed into:

[0036]

[0037] make Formula (2) can be transformed into:

[0038] Cp=x 0 +hF (3)

[0039] Formula (3) is a linear model, where x 0 and h are model parameters.

[0040] because therefore

[0041] S1.2 Model of earlobe resistance changing with pressure

[0042] Since resistive current is caused by dielectric substances, it is determined by factors such as the permeability of the membrane to various dielectric substances and whether the dielectric substances exist in large quantities. External stimuli change the permeability of dielectric substances, affecting the concentration of internal and external dielectric substances. The concentration difference of internal and external dielectric substances obeys the Nernst equation, and resistance is inversely proportional to conductivity, while conductivity is proportional to the concentration of dielectric substances in the cell. From this, it can be deduced that the relationship between cell resistance and external stimuli.

[0043] The amount of water in the earlobe cells is related to the elasticity of the earlobe cells. Under different pressures, the permeability of the cell membranes of different earlobe cells changes differently, so their resistance is different.

[0044] The expression of the Nernst equation is as follows:

[0045]

[0046] Where, E is the electromotive force; E 0 is the standard electromotive force; R 0 is the ideal gas constant, equal to 8.314570 JK -1 .mol -1 , T is temperature, unit K; C i is the dielectric substance concentration of the cell membrane response resistance, C o is the dielectric substance concentration of the cell membrane response resistance outside, and the total amount of dielectric substance of the membrane response resistance inside and outside the membrane C T =C i +C o , F 0 is Faraday's constant, equal to 96485C.mol -1 ;n R is the number of dielectric substances transferred in response to resistance, in mol.

[0047] The internal energy of the electromotive force E can be converted into pressure work, which is proportional to PV. PV = a E, that is:

[0048]

[0049] Where: P is the pressure on the earlobe cells, a is the electromotive force conversion energy coefficient, and V is the volume of the earlobe cells;

[0050] The pressure P on the earlobe cells can be calculated using the pressure formula: Where F is the pressure, S is the effective area under the action of the parallel plate;

[0051] For earlobe cells, C o With C i The sum is certain, equal to the total amount of dielectric material C of the response resistance inside and outside the film T , Ci It is proportional to the conductivity, and the conductivity is the reciprocal of the resistance R, so, Can be expressed as Where R is the resistance, f 0 is the dielectric concentration C of the cell membrane response resistance i The proportional coefficient between the conversion of resistance and the resistance, therefore, equation (5) can be transformed into:

[0052]

[0053] Formula (6) is transformed into

[0054]

[0055] Formula (7) is transformed into

[0056]

[0057] Taking the exponents on both sides of formula (8) can be transformed into:

[0058]

[0059] Further deformation can be obtained:

[0060]

[0061] In formula (10), R is the resistance. Formula (10) can be transformed into:

[0062]

[0063] For the same sample under the same measurement environment, d, a, E in formula (11) 0 , R 0 ,T,n R 、F 0 , C T 、f 0 are all fixed values; Therefore, formula (11) can be transformed into:

[0064]

[0065] In formula (12), y 1 , k 1 and b 1 are the parameters of the model.

[0066] S1.3 Model of earlobe impedance changing with pressure

[0067] For the same sample to be measured under the same measurement environment, the impedance mainly depends on the concentration of the dielectric substances that respond to the impedance inside and outside the membrane. Therefore, the permeability of the membrane to the dielectric substances that respond to various impedances and the water content determine the cell impedance. For earlobe cells, the impedance depends even more on the concentration of the dielectric substances that respond to the impedance inside and outside the membrane. The external excitation changes the membrane permeability of the dielectric substances, affecting the concentration of the dielectric substances that respond to the impedance inside and outside the membrane. The concentration difference of the dielectric substances that respond to the impedance inside and outside the membrane also follows the Nernst equation. When the concentration of the dielectric substances that respond to the impedance outside the membrane is constant, the impedance is inversely proportional to the concentration of the dielectric substances that respond to the impedance inside the cell. From this, the relationship between the impedance of the cell and the external excitation can be deduced.

[0068] The amount of water in earlobe cells is related to the elasticity of earlobe cells. Under different pressures, the permeability of the dielectric substances that respond to the impedance of different earlobe cell membranes changes differently, so their impedances are different.

[0069] The expression of the Nernst equation is as shown in Equation (13):

[0070]

[0071] Among them, E is the electromotive force, E 0 is the standard electromotive force, R 0 is the ideal gas constant, equal to 8.314570 J·K -1 .mol -1 ; T is the temperature, in units of K; Q i is the concentration of the dielectric substances that respond to the impedance inside the cell membrane, Q o is the concentration of the dielectric substances that respond to the impedance outside the cell membrane. The total amount of the dielectric substances that respond to the impedance inside and outside the membrane Q = Q i + Q o , F 0 is the Faraday constant, equal to 96485 C·mol -1 ; n Z is the transfer number of the dielectric substances that respond to the impedance, in units of mol.

[0072] The internal energy of the electromotive force E can be converted into pressure work, which is proportional to PV. PV = aE, that is:

[0073]

[0074] Among them: P is also the pressure exerted on the earlobe cells, a is also the energy conversion coefficient of the electromotive force, and V is also the volume of the earlobe cells;

[0075] The pressure P exerted on the earlobe cells can be obtained from the pressure formula. The pressure formula: Among them, F is also the force, and S is the effective area under the action of the parallel plates;

[0076] For earlobe cells, Q o With Q i The sum is certain and equal to the total amount of dielectric material Q, Q of the response impedance inside and outside the film i It is proportional to the conductivity of the dielectric material of the response impedance, and the conductivity of the dielectric material of the response impedance is the inverse of the impedance Z. Therefore, Can be expressed as Z is impedance, J 0 is the dielectric concentration Q of the cell membrane response impedance i The proportional coefficient between the impedance and the impedance is thus converted into (14):

[0077]

[0078] Formula (15) is transformed into

[0079]

[0080] Formula (16) can be transformed into:

[0081]

[0082] Taking the exponents on both sides of formula (17), it can be transformed into:

[0083]

[0084] Further deformation can be obtained:

[0085]

[0086] In formula (19), Z is the impedance. Formula (19) can be transformed into:

[0087]

[0088] For the same sample under the same measurement environment, d, a, E in formula (20) 0 , R 0 ,T,n Z 、F 0 , Q, J 0 are all fixed values, let Therefore, formula (20) can be transformed into:

[0089]

[0090] Where y 2 , k 2 and b 2 are the parameters of the model.

[0091] S1.4 Model of earlobe capacitance changing with pressure

[0092] For the same sample under the same measurement environment, the size of the capacitive reactance mainly depends on the concentration of the dielectric substance that responds to the capacitive reactance inside and outside the membrane. Therefore, the permeability of the membrane to various dielectric substances that respond to the capacitive reactance determines the size of the cell capacitive reactance. For earlobe cells, the capacitive reactance depends even more on the concentration of the dielectric substance that responds to the capacitive reactance inside and outside the membrane. External excitation changes the membrane permeability of the dielectric substance, affecting the concentration of the dielectric substance that responds to the capacitive reactance inside and outside the membrane. The concentration difference of the dielectric substance that responds to the capacitive reactance inside and outside the membrane also obeys the Nernst equation. When the concentration of the dielectric substance that responds to the capacitive reactance outside the membrane is constant, the capacitive reactance is inversely proportional to the concentration of the dielectric substance that responds to the capacitive reactance inside the cell. It can be deduced that the cell's capacitive reactance is also related to external excitation.

[0093] The amount of water in the earlobe cells is related to the elasticity of the earlobe cells. Under different pressures, the permeability of the dielectric substance of the response capacitance of different earlobe cell membranes changes differently, so their capacitance is different.

[0094] The expression of the Nernst equation is as follows:

[0095]

[0096] Where E is the electromotive force, E 0 is the standard electromotive force, R 0 is the ideal gas constant, equal to 8.314570 JK -1 .mol -1 ; T is temperature, unit K; X i is the dielectric substance concentration in the cell membrane that responds to the capacitive reactance, X o is the concentration of dielectric substance outside the cell membrane that responds to capacitance, and the total amount of dielectric substance inside and outside the membrane that responds to capacitance is X = X i +X o , F 0 is Faraday's constant, equal to 96485C.mol -1 ;n XC It is the number of dielectric substances transferred in response to capacitive reactance, in mol.

[0097] The internal energy of the electromotive force E can be converted into pressure work, which is proportional to PV. PV = a E, that is:

[0098]

[0099] Among them: P is also the pressure on the earlobe cells, a is also the electromotive force conversion energy coefficient, and V is also the volume of the earlobe cells;

[0100] The pressure P on the earlobe cells can be calculated using the pressure formula: Where F is also the pressure, and S is the effective area under the action of the parallel plate;

[0101] For earlobe cells, X o With X i The sum is certain, equal to the total amount of dielectric material X, X inside and outside the film that responds to the capacitive reactance i It is proportional to the conductivity of the dielectric material that responds to the capacitive reactance, and the conductivity of the dielectric material that responds to the capacitive reactance is the reciprocal of the capacitive reactance Xc. Therefore, Can be expressed as Xc is the capacitive reactance, L 0 is the dielectric substance concentration X in the cell membrane that responds to the capacitive reactance i The proportional coefficient between the conversion of and capacitive reactance is thus (23) transformed into:

[0102]

[0103] Formula (24) is transformed into

[0104]

[0105] Formula (25) can be transformed into:

[0106]

[0107] Taking the exponents on both sides of formula (26) can be transformed into:

[0108]

[0109] Further deformation can be obtained:

[0110]

[0111] In formula (28), Xc is the capacitive reactance. Formula (28) can be transformed into:

[0112]

[0113] For the same sample under the same measurement environment, d, a, E in formula (29) 0 , R 0 ,T,n XC 、F 0 ,X,L 0 are all fixed values, let Therefore, formula (29) can be transformed into:

[0114]

[0115] In formula (30), y 3 , k 3 and b 3are the parameters of the model.

[0116] S1.5 Model of earlobe reactance changing with pressure

[0117] Under different pressures, the permeability of the dielectric substance of the response inductive reactance of different earlobe cell membranes also changes differently, so their inductive reactance is different.

[0118] The expression of the Nernst equation is as follows:

[0119]

[0120] Where E is the electromotive force, E 0 is the standard electromotive force, R 0 is the ideal gas constant, equal to 8.314570 JK -1 .mol -1 ; T is temperature, unit K; M i is the dielectric substance concentration in the cell membrane that responds to inductive reactance, M o is the concentration of dielectric substance outside the cell membrane that responds to inductive reactance, and the total amount of dielectric substance inside and outside the membrane that responds to inductive reactance M T =M i +M o , F 0 is Faraday's constant, equal to 96485C.mol -1 ;n XL It is the number of dielectric substances transferred in response to inductive reactance, in mol.

[0121] The internal energy of the electromotive force E can be converted into pressure work, which is proportional to PV. PV = a E, that is:

[0122]

[0123] Among them: P is also the pressure on the earlobe cells, a is also the electromotive force conversion energy coefficient, and V is also the volume of the earlobe cells;

[0124] The pressure P on the earlobe cells can be calculated using the pressure formula: Where F is also the pressure, and S is the effective area under the action of the parallel plate;

[0125] For earlobe cells, M o With M i The sum is certain, equal to the total amount of dielectric material M of the response inductive reactance inside and outside the membrane T , M i It is proportional to the conductivity of the dielectric material that responds to the inductive reactance, and the conductivity of the dielectric material that responds to the inductive reactance is the reciprocal of the inductive reactance Xl. Therefore, Can be expressed as Xl is the inductive reactance, P 0is the dielectric substance concentration M in the cell membrane that responds to the inductive reactance i The proportional coefficient between the conversion of and inductive reactance is, therefore, equation (32) can be transformed into:

[0126]

[0127] Formula (33) is transformed into

[0128]

[0129] Formula (34) can be transformed into:

[0130]

[0131] Taking exponents on both sides of formula (35) can be transformed into:

[0132]

[0133] Further deformation can be obtained:

[0134]

[0135] In formula (37), Xl is the inductive reactance. Formula (37) can be transformed into:

[0136]

[0137] For the same sample under the same measurement environment, d, a, E in formula (38) 0 , R 0 ,T,n XL 、F 0 、M T , P 0 are all fixed values, let Therefore, formula (38) can be transformed into:

[0138]

[0139] In formula (39), y 4 , k 4 and b 4 are the parameters of the model.

[0140] S1.6 Calculation of earlobe resting electrical parameters

[0141] Based on S1.2 earlobe resistance variation with pressure model (12) When F = 0 is substituted into equation (12), the earlobe resting resistance IR is obtained: IR = y 1 +k 1 Since it is a parallel circuit measurement method, the earlobe cell unit resting resistance IR U=d×IR.

[0142] Based on the S1.3 earlobe impedance variation with pressure model (21) When F = 0 is substituted into equation (21), the earlobe resting impedance IZ is obtained: IZ = y 2 +k 2 ; Since it is a parallel circuit measurement method, the unit resting impedance of the earlobe cell IZ U =d×IZ.

[0143] Based on S1.4 earlobe capacitance change with pressure model (30) When F = 0 is substituted into equation (30), the earlobe resting capacitive reactance IXc is obtained: IXc = y 3 +k 3 ; Because it is a parallel circuit measurement method, the resting capacitance of the earlobe cell unit is IXc U =d×IXc. The capacitance converted from the earlobe resting capacitive reactance IXc is the earlobe resting capacitance ICP. The formula for converting the earlobe resting capacitive reactance into the earlobe resting capacitance is: Where IXc is the resting capacitive reactance of the earlobe, ICP is the resting capacitance of the earlobe, f is the test frequency, and π is the ratio of pi, which is equal to 3.1416. Since it is a parallel circuit measurement method, the resting capacitance per earlobe cell ICP is U =ICP / d.

[0144] Based on the S1.5 model of earlobe reactance changing with pressure (39) When F = 0 is substituted into equation (39), the resting inductive reactance of the earlobe IXl is obtained: IXl = y 4 +k 4 ; Because it is a parallel circuit measurement method, the resting inductive reactance of the earlobe cell unit is IXl U =d×IXl.

[0145] Step 2: Calculate the energy conversion capacity, intracellular water and nutrient transport capacity, intracellular dielectric substance transfer capacity and cell metabolism capacity of earlobe cells based on the model parameters and earlobe resting electrical parameters. Specifically, the following steps are included:

[0146] S2.1 Obtain the energy conversion capacity of earlobe cells based on the model parameters and the earlobe resting electrical parameters.

[0147] The energy conversion capacity of earlobe cells includes the unit endogenous energy ΔG based on resistance. R-U and endogenous energy ΔG based on resistance R , Unit endogenous energy ΔG based on capacitive reactance Xc-U and endogenous energy ΔG based on capacitive reactance Xc , Unit endogenous energy ΔG based on inductive reactance Xl-Uand endogenous energy ΔG based on inductive reactance Xl , Unit endogenous energy ΔG based on impedance Z-U and the endogenous energy ΔG based on impedance Z , average unit endogenous energy ΔG U , Capacitive reactance endogenous energy / Inductive reactance endogenous energy RG Xc-xl ; Unit endogenous energy ΔG based on resistance R-U The calculation method is: Endogenous energy ΔG based on resistance R The calculation method is: ΔG R =ΔG R-U d; Unit endogenous energy ΔG based on impedance Z-U The calculation method is: Endogenous energy ΔG based on impedance Z The calculation method is: ΔG Z =ΔG Z-U ×d; unit endogenous energy ΔG based on capacitive reactance Xc-U The calculation method is: Endogenous energy ΔG based on capacitive reactance Xc The calculation method is: ΔG Xc =ΔG Xc-U ×d; unit endogenous energy ΔG based on inductive reactance Xl-U The calculation method is: Endogenous energy ΔG based on inductive reactance Xl The calculation method is: ΔG Xl =ΔG Xl-U ×d; average unit endogenous energy ΔG U The calculation method is: Capacitive reactance endogenous energy / inductive reactance endogenous energy RG Xc-xl The calculation method of RG is: Xc-xl＝ ΔG Xc-U / ΔG Xl-U .

[0148] S2.2, based on the model parameters and the resting electrical parameters of the earlobe, the intracellular water transport capacity of the earlobe cells is obtained.

[0149] The intracellular water transport capacity of earlobe cells includes intracellular water holding capacity IWHC, intracellular water transport efficiency IWTTE, intracellular water holding time IWHT and intracellular water transport rate IWTTR; the method for calculating the intracellular water holding capacity IWHC based on the earlobe resting capacitance ICP is: The method for calculating the intracellular water transport efficiency IWTTE based on the earlobe thickness d and the intracellular water holding capacity IWHC is: According to the earlobe resting capacitance ICP and earlobe resting impedance IZ, the calculation formula for the intracellular water holding time IWHT is: IWHT = ICP × IZ; according to the intracellular water holding capacity IWHC and the intracellular water holding time IWHT, the calculation formula for the intracellular water transport rate IWTTR is:

[0150] S2.3, based on the model parameters and the resting electrical parameters of the earlobe, the intracellular nutrient transport capacity of the earlobe cells is obtained.

[0151] The intracellular nutrient transport capacity of earlobe cells includes intracellular nutrient transport rate INTTR, intracellular nutrient transport efficiency INTTE, active transport unit flow rate UATTF, intracellular nutrient active transport capacity NATTC, intracellular nutrient transport unit flow rate UNTTF, intracellular nutrient transport capacity NTTC, intracellular nutrient passive transport unit flow rate UPTTF, intracellular nutrient passive transport capacity NPTTC, and intracellular active / passive transport capacity ratio RAP; the intracellular nutrient transport rate INTTR and the intracellular water transport rate IWTTR are similar in concept and have the same value; the calculation formula of the intracellular nutrient transport efficiency INTTE is: The calculation formula of intracellular active transport unit flow UATTF is: The calculation formula of intracellular nutrient active transport capacity NATTC is: NATTC = UATTF × INTTR; the intracellular nutrient transport unit flow UNTTF can be expressed as: The calculation formula of intracellular nutrient transport capacity NTTC is: NTTC = UNTTF × INTTR; the calculation formula of intracellular passive transport unit flow UPTTF is: UPTTF = UNTTF - UATTF; the calculation formula of intracellular nutrient passive transport capacity NPTTC is: NPTTC = NTTC - NATTC; the calculation formula of intracellular active / passive transport capacity ratio RAP is:

[0152] S2.4 Obtain the dielectric substance transfer capacity of earlobe cells based on the model parameters and the earlobe resting electrical parameters.

[0153] The intracellular dielectric transport capacity includes the number of intracellular dielectric substances transferred, the transport force and resistance of various substances, the transport capacity of various substances, and the transport ratio of capacitive / sensitive substances RTTC. C-L ; Wherein, the transfer number of various dielectric substances in the cell includes the transfer number of dielectric substances Kn of the response resistance R 、Dielectric material transfer number Kn corresponding to capacitive reactance XC , Dielectric material transfer number Kn of response inductive reactance XL And the dielectric material transfer number Kn of the response impedance ZThe conduction force and conduction resistance of various substances include the conduction force of resistive substances ICF R , resistive material conduction resistance ICR R , Capacitive Material Conductivity ICF C , Capacitive material conduction resistance ICR C , Inductive Material Conductivity ICF L , Inductive material conduction resistance ICR L , total dielectric conductivity ICF Z and total dielectric conductivity resistance ICR Z ; The transport capacity of various substances includes the transport capacity of resistive substances TTC R , TTC C , sensory material transport capacity TTC L Total dielectric transport capacity (TTC) Z ; Dielectric material transfer number Kn of response resistance R The calculation method of Kn is: R =lnk 1 -lny 1 ; Dielectric material transfer number Kn in response to capacitive reactance XC The calculation method of Kn is: XC =lnk 3 -lny 3 ; Dielectric material transfer number Kn in response to inductive reactance XL The calculation method of Kn is: XL =lnk 4 -lny 4 ; Dielectric material transfer number Kn of response impedance Z The calculation method of Kn is: Z =lnk 2 -lny 2 ; Resistive material conductivity ICF R The calculation method is: Resistive material conduction resistance ICR R The calculation method is: ICR R =-b 1 k 1 , Capacitive Material Conductivity ICF C The calculation method is: Capacitive material conduction resistance ICR C The calculation method is: ICR C =-b 3 k 3 , Inductive Material Conductivity ICF L The calculation method is: Inductive material conduction resistance ICR L The calculation method is: ICR L =-b4 k 4 ; Total dielectric conductivity ICF Z The calculation method is: Total dielectric conductivity resistance ICR Z The calculation method is: ICR Z =-b 2 k 2 ; Resistive material transport capacity TTC R The calculation method is: TTC R =ICF R / Kn R ; TTC C The calculation method is: TTC C =ICF C / Kn XC ; TTC (transport capacity of sensory substances) L The calculation method is: TTC L =ICF L / Kn XL ; Total dielectric transport capacity TTC Z The calculation method is: TTC Z =ICF Z / Kn Z ; Capacitive / sensible material transport ratio RTTC C-L The calculation formula is: RTTC C-L =TTC C / TTC L .

[0154] S2.5 obtains the cell metabolic capacity based on the model parameters, earlobe resting electrical parameters and intracellular nutrient transport capacity.

[0155] The metabolic capacity of earlobe cells includes earlobe cell metabolic rate MR, earlobe cell metabolic flux MF, cell metabolic intensity MS and earlobe cell relative metabolic activity MA; the method for obtaining earlobe cell metabolic rate MR is: MR = INTTR × NATTC; the method for obtaining earlobe cell metabolic flux MF is: The method for obtaining the cell metabolic intensity MS is: MS = ln [MF]; the method for obtaining the relative metabolic activity MA of earlobe cells is:

[0156] It should be noted that in steps S2.1 to S2.5, the calculation method of each parameter is as follows:

[0157] Based on the earlobe resistance variation model obtained in S1.2 and the earlobe resting resistance and earlobe cell unit resting resistance obtained in S1.6, and Perform deformation operations. Here, E 0 , R 0 , T and F 0 is a fixed value, The number n is transferred only to the dielectric material of the response resistance R Proportional, set Kn R =n R , then: The dielectric material transfer number Kn of the response resistor R The calculation method of Kn is: R =lnk 1 -lny 1 Similarly, and Perform deformation calculation to obtain unit endogenous energy based on resistance Endogenous energy ΔG based on resistance R =ΔG R-U d.

[0158] According to Ohm's law, for the current passing through a resistor, the current I R =U / R, where U is the measured voltage; I R is the current through the resistor; therefore In the formula, I R To measure the current through the resistor with voltage U. Derivative of the above formula: Resistive Material Conductivity ICF R It is defined as I when F = 0 R ′, which is calculated as: According to the derivative formula of the relationship model between resistance and pressure: Resistive material conduction resistance ICR R It is defined as R' when F = 0, and its calculation method is: ICR R =-b 1 k 1 .

[0159] Based on the earlobe impedance variation model obtained in S1.3 and the earlobe resting impedance and earlobe cell unit resting impedance obtained in S1.6, and Perform deformation operations. Here, E 0 , R 0 , T and F 0 is a fixed value, The number n is transferred only to the dielectric material with the response impedance Z Proportional, set Kn Z =n Z , then: The dielectric material transfer number Kn of the response impedance ZThe calculation method of Kn is: Z =lnk 2 -lny 2 Similarly, and Perform deformation calculation to obtain unit endogenous energy based on impedance Endogenous energy ΔG based on impedance Z =ΔG Z-U d.

[0160] According to Ohm's law, for the current passing through the impedance, the current I Z =U / Z, where U is the measured voltage; I Z is the current through the impedance; therefore In the formula, I Z To measure the current through the impedance with voltage U. Derivative of the above formula, we get: Total dielectric conductivity ICF Z It is defined as I when F = 0 Z ′, which is calculated as: According to the derivative formula of the relationship model between impedance and pressure: Total dielectric conductivity resistance ICR Z It is defined as Z' when F = 0, and its calculation method is: ICR Z =-b 2 k 2 .

[0161] Based on the earlobe capacitance change with pressure model obtained in S1.4 and the earlobe resting capacitance, earlobe cell unit resting capacitance, earlobe resting capacitance, and earlobe cell unit resting capacitance obtained in S1.6, and Perform deformation operations. Here, E 0 , R 0 , T and F 0 is a fixed value, The number n is transferred only to the dielectric material with the corresponding capacitive reactance XC Proportional, set Kn XC =n XC , then: The dielectric material transfer number Kn of the response capacitive reactance XC The calculation method of Kn is: XC =lnk 3 -lny 3 Similarly, and Perform deformation calculation to obtain unit endogenous energy based on capacitive reactance Endogenous energy ΔG based on capacitive reactance Xc=ΔG Xc-U d.

[0162] According to Ohm's law, for the current passing through the capacitive reactance, the current I Xc =U / Xc, where U is the measured voltage; I Xc is the current through the capacitive reactance; therefore In the formula, I Xc To measure the current through the capacitive reactance with voltage U. Derivative of the above formula: Capacitive Conductivity ICF C It is defined as I when F = 0 Xc ′, which is calculated as: According to the derivative formula of the relationship model between capacitive reactance and pressure: Capacitive material conduction resistance ICR C It is defined as Xc′ when F=0, and its calculation method is: ICR Xc =-b 3 k 3 .

[0163] Based on the model of earlobe inductive reactance changing with pressure obtained in S1.4 and the earlobe resting inductive reactance and earlobe cell unit resting inductive reactance obtained in S1.6, and Perform deformation operations. Here, E 0 , R 0 , T and F 0 is a fixed value, The number n is transferred only to the dielectric material with the corresponding inductive reactance XL Proportional, set Kn XL =n XL , then: The dielectric material transfer number Kn of the response inductive reactance XL The calculation method of Kn is: XL =lnk 4 -lny 4 ;same, and Perform deformation calculation to obtain unit endogenous energy based on inductive reactance Endogenous energy ΔG based on inductive reactance Xl =ΔG Xl-U d.

[0164] According to Ohm's law, for the current passing through the inductive reactance, the current I Xl =U / Xl, where U is the measured voltage; I Xl is the current through the inductive reactance; therefore In the formula, I XlTo measure the current through the inductive reactance with voltage U. Derivative of the above formula: Capacitive Conductivity ICF L It is defined as I when F = 0 L ′, which is calculated as: According to the derivative formula of the relationship model between inductive reactance and pressure: Capacitive material conduction resistance ICR L It is defined as Xl' when F = 0, and its calculation method is: ICR L =-b 4 k 4 .

[0165] The endogenous energy of the electrical components of human cells drives different physiological functions. The average unit endogenous energy ΔG U It can reflect the overall energy conversion capacity of the human body, the average unit endogenous energy ΔG U The calculation method is: Capacitive reactance endogenous energy / inductive reactance endogenous energy RG Xc-xl It is an important indicator of whether the energy is balanced, and has extremely important value in the diagnosis of "yin and yang balance" in traditional Chinese medicine. Xc-xl The calculation method of RG is: Xc-xl＝ ΔG Xc-U / ΔG Xl-U , the best state of yin and yang balance capacitive resistance endogenous energy / inductive resistance endogenous energy RG Xc-xl The value of is 1.

[0166] According to the principles of mechanics, the acceleration of a substance is proportional to the force it receives and inversely proportional to its mass, so we can define: the resistance to transport capacity TTC R For:TTC R =ICF R / Kn R ; TTC C For:TTC C =ICF C / Kn XC ; TTC (transport capacity of sensory substances) L For:TTC L =ICF L / Kn XL ; Total dielectric transport capacity TTC Z For:TTC Z =ICF Z / Kn Z . RTTC C-L The calculation formula is: RTTC C-L =TTC C / TTCL .

[0167] Since the cell (organelle) is a spherical structure, the water content in human earlobe cells is more than 60%. The capacitance of earlobe cells can borrow the calculation formula of a concentric spherical capacitor:

[0168]

[0169] Here, π is the pi equal to 3.1416, C is the capacitance of the concentric spherical capacitor, ε is the dielectric constant of the electrolyte, R 1 , R 2 are the radii of the outer sphere and the inner sphere respectively. In the cell (organelle), R 2 -R 1 can be used as the thickness of the membrane, R 1 ≈R 2 , for the same type of cells (organelles) in the same earlobe tissue and organ, the thickness of the membrane is constant and ε is constant. Therefore, there is the following relationship between the volume of the cell (organelle) and the capacitance C of the cell:

[0170]

[0171] In formula (41), for the same sample, α is constant, the volume is proportional to the water holding capacity, that is, the water holding capacity of the cell is proportional to is proportional. Therefore, can be used to characterize the water holding capacity of earlobe cells. The method for calculating the intracellular water holding capacity IWHC based on the earlobe resting capacitance ICP is:

[0172] The earlobe thickness d represents the number and volume of cells. The intracellular water holding capacity IWHC supports the number and volume d of earlobe cells, and can be characterized as the intracellular water transport efficiency IWTTE. The calculation method is:

[0173] According to Ohm's law, for the current passing through the impedance, the current I Z =U / Z, where U is the measured voltage and I Z is the current. Z is the impedance; at the same time, the current is also equal to the capacitance multiplied by the time derivative of the voltage. After integral transformation, the time t is the product of the capacitance and the impedance. Therefore, based on the earlobe resting capacitance ICP and the earlobe resting impedance IZ, the calculation formula for the intracellular water holding time IWHT of earlobe cells based on electrophysiological parameters is: IWHT = ICP × IZ. Based on the intracellular water holding capacity IWHC and the intracellular water holding time IWHT, the intracellular water transport rate IWTTR can be calculated. Its calculation formula is: The intracellular nutrient transport rate INTTR is conceptually similar to the intracellular water transport rate IWTTR and has the same value.

[0174] The calculation formula of earlobe resting resistance IR is: IR 1 IR 2 IR 3 ,…IR n is the resting resistance of each unit cell membrane. Assuming that the resting resistance of each unit cell membrane is equal, that is, IR 1 =IR 2 =IR 3 =…=IR n =IR 0 , then the formula for calculating the earlobe resting resistance is: Where n can be characterized as the number of proteins and lipids that cause electrical resistance in biological tissues.

[0175] The calculation formula of earlobe resting capacitive reactance IXc is: Among them IXc 1 IXc 2 IXc 3 ,…IXc p is the resting capacitive reactance of each unit cell membrane. Assuming that the resting capacitive reactance of each unit cell membrane is equal, that is, IXc 1 =IXc 2 =IXc 3 =…=IXc p =IXc 0 , then the calculation formula for the earlobe resting capacitive reactance is: Among them, p can be characterized as the number of proteins that cause the resistance of biological tissues, especially surface proteins (peripheral proteins).

[0176] The calculation formula of earlobe resting inductive reactance IXl is: Among them IXl 1 IXl 2 IXl 3 ,…IXl q is the resting inductive reactance of each unit cell membrane, assuming that the resting inductive reactance of each unit cell membrane is equal, that is, IXl 1 =IXl 2 =IXl 3 =…=IXl q =IXl 0 , then the calculation formula for the resting inductive reactance of the earlobe is: Where q can be characterized as the number of protein-binding proteins (intrinsic proteins) that cause resistance in biological tissues, especially the number of transport proteins therein.

[0177] Earlobe resting sense resistance countdown IXl - The calculation formula is: Earlobe resting sense resistance inverse IXc -The calculation formula is: The reciprocal of the earlobe resting resistance R - The calculation formula is: The ratio of the cell's material transport capacity caused by surface proteins (peripheral proteins) to the total material transport capacity determines the passive nutrient transport capacity, while the ratio of the cell's material transport capacity caused by bound proteins to the total material transport capacity determines the active nutrient transport capacity. At the same time, due to the same measurement sample Therefore, the calculation formula of intracellular nutrient active transport capacity NATTC is: NATTC = UATTF × INTTR. Passive transport unit flow Since the same measurement sample The calculation formula of intracellular nutrient passive transport capacity NPTTC is: NPTTC = UPTTF × INTTR. The calculation formula of intracellular nutrient transport capacity NTTC is: NTTC = UNTTF × INTTR. The intracellular nutrient transport efficiency INTTE of earlobe cells is expressed as

[0178] Metabolic capacity is related to bioelectricity. The greater the bioelectricity, the more complete the metabolism. Therefore, the bioelectricity I based on the resting resistance of the earlobe is R =U / IR, bioelectric current I based on the resting capacitive reactance of the earlobe Xc =U / IXc, bioelectric current I based on the resting inductive reactance of the earlobe Xl =U / IXl and the biocurrent I based on the resting impedance of the earlobe IZ =U / IZ. Here, U represents the voltage applied during the measurement. Since it is a parallel connection, U is the same. Therefore, we can define the earlobe cell metabolic flow MF as: Cell metabolic intensity MS can be defined as the logarithm of MF with base e, representing the metabolic intensity driven by endogenous energy. The algorithm is: MS = ln[MF]. The method for obtaining the relative metabolic activity MA of earlobe cells is:

[0179] The ability to actively transport nutrients is related to the metabolic rate. The stronger the ability to actively transport nutrients, the greater the metabolic rate. Therefore, we define the metabolic rate of earlobe cells MR: MR = INTTR × NATTC.

[0180] According to the metabolic flow MF and metabolic rate MR of earlobe cells, the relative metabolic activity MA of earlobe based on electrophysiological information is redefined:

[0181] Step three, the data list obtained in the above steps is used to form a test report on the life and physical information of the human body of the subject.

[0182] Example 1

[0183] This embodiment provides a human body biophysical information detection report based on the electrical behavior and biophysical characteristics of earlobe cells of three adult males. The specific process is as follows, and the three adult males are numbered as sample 1, sample 2 and sample 3 respectively. Before the measurement, the sample to be tested was kept in a resting state for 20 minutes. Then, the parallel plate capacitance sensor was gently clamped in the center of the earlobe of the subject to be tested. The measuring voltage was set to 1.5V and the frequency was set to 3000Hz. The LCR meter was started in parallel mode for measurement. The measuring pressure was between 0.5N and 6N. The changes in capacitance, resistance, impedance, capacitive reactance and inductive reactance of the earlobe part of the human body in a resting state under 9 pressure levels were measured. According to the Gibbs free energy equation and the Nernst equation, a model of capacitance, resistance, impedance, capacitive reactance and inductive reactance changing with pressure was constructed to obtain the parameters of each model. According to the parameters of each model, the earlobe resting electrical parameters including earlobe thickness, earlobe resting capacitance, resting resistance, resting capacitive reactance, resting inductive reactance, resting impedance, earlobe cell unit resting capacitance, unit resting resistance, unit resting capacitive reactance, unit resting inductive reactance and unit resting impedance were obtained. Based on the model parameters and the resting electrical parameters of the earlobe, the energy conversion capacity, intracellular water transportation capacity, intracellular nutrient transportation capacity and intracellular dielectric substance transfer capacity of the earlobe cells are obtained; based on the model parameters, the resting electrical parameters of the earlobe and the intracellular nutrient transportation capacity, the metabolic capacity of the earlobe cells is obtained.

[0184] The energy conversion capacity of earlobe cells includes the unit endogenous energy ΔG based on resistance. R-U and endogenous energy ΔG based on resistance R , Unit endogenous energy ΔG based on capacitive reactance Xc-U and endogenous energy ΔG based on capacitive reactance Xc , Unit endogenous energy ΔG based on inductive reactance Xl-U and endogenous energy ΔG based on inductive reactance Xl , Unit endogenous energy ΔG based on impedance Z-U and the endogenous energy ΔG based on impedance Z , average unit endogenous energy ΔG U , Capacitive reactance endogenous energy / Inductive reactance endogenous energy RG Xc-xl. The intracellular water transport capacity of earlobe cells includes the intracellular water holding capacity IWHC, the intracellular water transport efficiency IWTTE, the intracellular water holding time IWHT and the intracellular water transport rate IWTTR. The intracellular nutrient transport capacity of earlobe cells includes the intracellular nutrient transport rate INTTR, the intracellular nutrient transport efficiency INTTE, the active transport unit flow rate UATTF, the intracellular nutrient active transport capacity NATTC, the intracellular nutrient transport unit flow rate UNTTF and the intracellular nutrient transport capacity NTTC. The intracellular dielectric substance transfer capacity of earlobe cells includes the transfer number of various dielectric substances in the cell, the transport force and transport resistance of various substances, the transport capacity of various substances and the receptive / sensitive substance transport ratio RTTC. C-L ; The number of various dielectric substances transferred in the cell, including the number of dielectric substances transferred with response resistance Kn R 、Dielectric material transfer number Kn corresponding to capacitive reactance XC , Dielectric material transfer number Kn of response inductive reactance XL And the dielectric material transfer number Kn of the response impedance Z ; The conductivity and resistance of various substances include the conductivity of resistive substances ICF R , resistive material conduction resistance ICR R , Capacitive Material Conductivity ICF C , Capacitive material conduction resistance ICR C , Inductive Material Conductivity ICF L , Inductive material conduction resistance ICR L , total dielectric conductivity ICF Z and total dielectric conductivity resistance ICR Z ; The transport capacity of various substances, including the transport capacity of resistive substances TTC R , TTC C , sensory material transport capacity TTC L Total dielectric transport capacity (TTC) Z ; The metabolic capacity of earlobe cells includes earlobe cell metabolic rate MR, earlobe cell metabolic flux MF, cell metabolic intensity MS and earlobe cell relative metabolic activity MA.

[0185] The data obtained in the above steps are tabulated to form a test report of the subject's life physical information as shown in Table 1.

[0186] Table 1 Human body life physics information detection report

[0187]

[0188]

[0189]

[0190] As can be seen from Table 1, similar to indicators such as human blood pressure, the values of the earlobe resting electrical parameters, including the unit resting capacitance, unit resting resistance, unit resting capacitive reactance, unit resting inductive reactance, and unit resting impedance of earlobe cells, have a certain range. Samples 1, 2, and 3 are very close in 12 indicators. Among these 12 indicators, 6 are related to the energy conversion ability, namely the unit endogenous energy ΔG based on resistance R-U , the unit endogenous energy ΔG based on impedance Z-U , the unit endogenous energy ΔG based on capacitive reactance Xc-U , the unit endogenous energy ΔG based on inductive reactance Xl-U , the average unit endogenous energy ΔG U , and the ratio of capacitive reactance endogenous energy to inductive reactance endogenous energy RG Xc-xl . Moreover, in the same sample, the 5 indicators of the unit endogenous energy ΔG based on resistance R-U , the unit endogenous energy ΔG based on impedance Z-U , the unit endogenous energy ΔG based on capacitive reactance Xc-U , the unit endogenous energy ΔG based on inductive reactance Xl-U , and the average unit endogenous energy ΔG U are similar, and the value of the ratio of capacitive reactance endogenous energy to inductive reactance endogenous energy RG Xc-xl is close to 1, indicating that the "yin-yang" of the three adult males represented by the three samples is balanced in traditional Chinese medicine. Among these 12 indicators, 4 are related to the dielectric substance transfer ability, namely the number of dielectric substance transfers Kn in response to resistance R , the number of dielectric substance transfers Kn in response to capacitive reactance XC , the number of dielectric substance transfers Kn in response to inductive reactance XL , and the number of dielectric substance transfers Kn in response to impedance Z , which indicates that the dielectric substance transfer modes of normal human bodies are similar. Among these 12 indicators, 2 are related to the water transport ability, namely the intracellular water holding time IWHT and the intracellular water transport efficiency IWTTE, which also indicates that the water transport modes of normal human bodies are similar. These results have good repeatability, indicating that the present invention has good credibility.

[0191] The d value of the earlobe thickness of Sample 3 is smaller than that of Samples 1 and 2 because the earlobe thickness of Sample 3 is small, which is consistent with the actual situation. In addition, the intracellular water transport rate IWTTR, the intracellular nutrient active transport ability NATTC, the capacitive substance conduction force ICF C , and the inductive substance conduction force ICF LThe results of the present invention are consistent. The body shape of sample 3 is significantly thinner than that of sample 1 and sample 2, which can also be explained by the above results (which is consistent with the actual situation).

[0192] In addition, compared with sample 3, sample 1 is obviously more "humid", because it can be seen from Table 1 that the unit resting capacitance ICP of the earlobe cell of sample 3 U The capacitance value is the largest, and the earlobe cell unit resting resistance IR U and earlobe cell unit resting resistance IXl U The values ​​of are significantly greater than those of sample 1, and the resting capacitance of earlobe cells is IXc. U and the resting impedance of the earlobe cell unit IZ U are significantly smaller than sample 1.

[0193] Based on the above ideal embodiments of the present invention, the relevant staff can make various changes and modifications without departing from the technical concept of the present invention through the above description. The technical scope of the present invention is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. A method for quickly acquiring human life physical information, characterized in that: The following steps are included: Step 1: After the sample to be tested is kept in a resting state for a period of time, a parallel plate capacitance sensor is used in a parallel mode to measure the changes in capacitance, resistance, impedance, capacitive reactance and inductive reactance of the earlobe of the human body in a resting state under different small pressures, and a model of capacitance, resistance, impedance, capacitive reactance and inductive reactance changing with pressure is constructed to obtain the resting electrical parameters of the earlobe; Step 2: Calculate the energy conversion capacity, intracellular water and nutrient transport capacity, intracellular dielectric substance transfer capacity and cell metabolism capacity of earlobe cells based on the model parameters and earlobe resting electrical parameters; Step three, the data list obtained in the above steps is used to form a test report on the life and physical information of the human body of the subject.

2. The method for rapidly acquiring human life physical information according to claim 1, characterized in that: In step 1, the earlobe resting electrical parameters include earlobe thickness d, earlobe resting capacitance ICP, earlobe resting resistance IR, earlobe resting capacitive reactance IXc, earlobe resting inductive reactance IXl, earlobe resting impedance IZ, earlobe cell unit resting capacitance ICP U 、Earlobe cell unit resting resistance IR U , resting capacitance of earlobe cells IXc U , resting resistance of earlobe cell unit IXl U and the cell unit resting impedance IZ U .

3. The method for rapidly acquiring human life physical information according to claim 2, characterized in that: The calculation method of the earlobe resting resistance IR is: IR=y1+k1, where y1 and k1 are the parameters of the earlobe resistance variation model with pressure, and the earlobe cell unit resting resistance IR U The calculation method is: IR U =IR×d; the calculation method of the earlobe resting impedance IZ is: IZ=y2+k2, where y2 and k2 are the parameters of the earlobe impedance change model with pressure, and the earlobe cell unit resting impedance IZ U The calculation method of IZ is: U =IZ×d; the calculation method of the earlobe resting capacitive reactance IXc is: IXc=y3+k3, where y3 and k3 are the parameters of the earlobe capacitive reactance changing with pressure model, and the earlobe cell unit resting capacitive reactance IXc U The calculation method is: IXc U =IXc×d; the calculation method of the earlobe resting inductive reactance IXl is: IXl=y4+k4, where y4 and k4 are the parameters of the model of the earlobe inductive reactance changing with pressure, and the earlobe cell unit resting inductive reactance IXl U The calculation method is: IXl U = IXl × d; the method of calculating the earlobe resting capacitance ICP is: Where f is the test frequency, the earlobe cell unit resting capacitance ICP U The calculation method is: ICP U =ICP / d, the calculation method of earlobe thickness d is: Wherein U is the test voltage, and h is the parameter of the model of earlobe cell capacitance changing with pressure.

4. The method for rapidly acquiring human life physical information according to claim 2, characterized in that: In step 2, the intracellular water and nutrient transportation capacity includes the intracellular water transportation capacity of earlobe cells and the intracellular nutrient transportation capacity of earlobe cells.

5. The method for rapidly acquiring human life physical information according to claim 4, characterized in that: The intracellular water transport capacity of the earlobe cell includes the intracellular water holding capacity IWHC, the intracellular water transport efficiency IWTTE, the intracellular water holding time IWHT and the intracellular water transport rate IWTTR; the method for calculating the intracellular water holding capacity IWHC based on the earlobe resting capacitance ICP is: The method for calculating the intracellular water transport efficiency IWTTE based on the earlobe thickness d and the intracellular water holding capacity IWHC is: According to the earlobe resting capacitance ICP and earlobe resting impedance IZ, the calculation formula for the intracellular water holding time IWHT is: IWHT = ICP × IZ; according to the intracellular water holding capacity IWHC and the intracellular water holding time IWHT, the calculation formula for the intracellular water transport rate IWTTR is:

6. The method for rapidly acquiring human life physical information according to claim 4, characterized in that: The intracellular nutrient transport capacity of the earlobe cells includes the intracellular nutrient transport rate INTTR, the intracellular nutrient transport efficiency INTTE, the active transport unit flow rate UATTF, the intracellular nutrient active transport capacity NATTC, the intracellular nutrient transport unit flow rate UNTTF, the intracellular nutrient transport capacity NTTC, the intracellular nutrient passive transport unit flow rate UPTTF, the intracellular nutrient passive transport capacity NPTTC, and the intracellular active / passive transport capacity ratio RAP; the calculation formula of the intracellular nutrient transport efficiency INTTE is: The calculation formula of the intracellular active transport unit flow UATTF is: The calculation formula of the intracellular nutrient active transport capacity NATTC is: NATTC = UATTF × INTTR; the intracellular nutrient transport unit flow UNTTF can be expressed as: The calculation formula of the intracellular nutrient transport capacity NTTC is: NTTC = UNTTF × INTTR; the calculation formula of the intracellular passive transport unit flow UPTTF is: UPTTF = UNTTF - UATTF; the calculation formula of the intracellular nutrient passive transport capacity NPTTC is: NPTTC = NTTC - NATTC; the calculation formula of the intracellular active / passive transport capacity ratio RAP is:

7. The method for rapidly acquiring human life physical information according to claim 4, characterized in that: The intracellular dielectric substance transfer capacity includes the number of intracellular dielectric substances transferred, the transport force and transport resistance of various substances, the transport capacity of various substances, and the transport ratio of capacitive / sensitive substances RTTC. C-L ; Wherein, the transfer number of various dielectric substances in the cell includes the transfer number of dielectric substances Kn of the response resistance R 、Dielectric material transfer number Kn corresponding to capacitive reactance XC , Dielectric material transfer number Kn of response inductive reactance XL And the dielectric material transfer number Kn of the response impedance Z The conduction force and conduction resistance of various substances include the conduction force of resistive substances ICF R , resistive material conduction resistance ICR R , Capacitive Material Conductivity ICF C , Capacitive material conduction resistance ICR C , Inductive Material Conductivity ICF L , Inductive material conduction resistance ICR L , total dielectric conductivity ICF Z and total dielectric conductivity resistance ICR Z ; The transport capacity of various substances includes the transport capacity of resistive substances TTC R , TTC C , sensory material transport capacity TTC L Total dielectric transport capacity (TTC) Z The dielectric material transfer number Kn of the response resistor R The calculation method of Kn is: R =lnk1-lny1; the dielectric material transfer number Kn of the response capacitive reactance XC The calculation method of Kn is: XC =lnk3-lny3; the dielectric material transfer number Kn of the response inductive reactance XL The calculation method of Kn is: XL =lnk4-lny4; the dielectric material transfer number Kn of the response impedance Z The calculation method of Kn is: Z =lnk2-lny2; the resistive material conduction force ICF R The calculation method is: The resistive material conduction resistance ICR R The calculation method is: ICR R =-b1k1, the capacitive material conduction force ICF C The calculation method is: The capacitive material conduction resistance ICR C The calculation method is: ICR C =-b3k3, the inductive material conduction force ICF L The calculation method is: The inductive material conduction resistance ICR L The calculation method is: ICR L =-b4k4; the total dielectric material conductivity ICF Z The calculation method is: The total dielectric material conductivity resistance ICR Z The calculation method is: ICR Z =-b2k2; the transport capacity of the resistive substance TTC R The calculation method is: TTC R =ICF R / Kn R ; The transport capacity of the capacitive substance TTC C The calculation method is: TTC C =ICF C / Kn XC ; The transport capacity of the sensory substance TTC L The calculation method is: TTC L =ICF L / Kn XL ; The total dielectric transport capacity TTC Z The calculation method is: TTC Z =ICF Z / Kn Z ; The transport ratio of the capacitive substance to the perceptual substance RTTC C-L The calculation formula is: RTTC C-L =TTC C / TTC L .

8. The method for rapidly acquiring human life physical information according to claim 4, characterized in that: The energy conversion capacity of the earlobe cells includes the unit endogenous energy ΔG based on resistance R-U and endogenous energy ΔG based on resistance R , Unit endogenous energy ΔG based on capacitive reactance Xc-U and endogenous energy ΔG based on capacitive reactance Xc , Unit endogenous energy ΔG based on inductive reactance Xl-U and endogenous energy ΔG based on inductive reactance Xl , Unit endogenous energy ΔG based on impedance Z-U and the endogenous energy ΔG based on impedance Z , average unit endogenous energy ΔG U , Capacitive reactance endogenous energy / Inductive reactance endogenous energy RG Xc-xl .

9. The method for rapidly acquiring human life physical information according to claim 8, characterized in that: The unit endogenous energy ΔG based on resistance R-U The calculation method is: The endogenous energy ΔG based on resistance R The calculation method is: ΔG R =ΔG R-U ×d; the unit endogenous energy ΔG based on impedance Z-U The calculation method is: The endogenous energy ΔG based on impedance Z The calculation method is: ΔG Z =ΔG Z-U ×d; the unit endogenous energy ΔG based on capacitive reactance Xc-U The calculation method is: The endogenous energy ΔG based on capacitive reactance Xc The calculation method is: ΔG Xc =ΔG Xc-U ×d; the unit endogenous energy ΔG based on inductive reactance Xl-U The calculation method is: The endogenous energy ΔG based on inductive reactance Xl The calculation method is: ΔG Xl =ΔG Xl-U ×d; the average unit endogenous energy ΔG U The calculation method is: The capacitive reactance endogenous energy / inductive reactance endogenous energy RG Xc-xl The calculation method of RG is: Xc-xl＝ ΔG Xc-U / ΔG Xl-U .

10. The method for rapidly acquiring human life physical information according to claim 2, characterized in that: The cell metabolic capacity includes the earlobe cell metabolic rate MR, the earlobe cell metabolic flow MF, the cell metabolic intensity MS and the earlobe cell relative metabolic activity MA. The method for obtaining the earlobe cell metabolic rate MR is: MR=INTTR×NATTC; the method for obtaining the earlobe cell metabolic flow MF is: The method for obtaining the cell metabolic intensity MS is: MS=ln[MF]; the method for obtaining the earlobe cell relative metabolic activity MA is:

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