Permeation promoting composition as well as preparation method and application thereof

Abstract

The invention discloses a permeation promoting composition which comprises dihydric alcohol, glucosamine and a plant extract, and the weight ratio of the plant extract to the dihydric alcohol to the glucosamine is (0.01-0.1): (1-3): (0.5-3). According to the present invention, the tetrahydropiperine, the 2, 3-butanediol and the hydrolyzed glucosaminoglycan are combined according to the weight ratio of 0.1: 2: 0.5, such that the optimal permeation effect can be achieved, and the skin irritation effect cannot be caused. The prepared whitening product has the advantages that the melanin inhibition rate is increased greatly through the combined action with the whitening components, the whitening effect is improved, meanwhile, the skin irritation effect is not caused, and the use safety is high.

Description

Technical Field

[0001] The invention relates to the field of makeup preparations, and in particular to a penetration-promoting composition and a preparation method and application thereof. Background Art

[0002] The stratum corneum is the armor on the surface of the skin, a barrier that isolates the environment and microorganisms, and protects the skin from damage by the external environment. However, the stratum corneum also limits the absorption of topical skin care products to a certain extent. In order to promote the penetration of various functional skin care products, permeation enhancers are generally added to skin care products. Traditional permeation enhancers such as ethanol, piperine, azone and other raw materials increase percutaneous penetration by changing the arrangement of stratum corneum lipids. However, there are certain risks in the use of such traditional permeation enhancers. For example, azone causes the skin structure to become loose and has a certain irritation to the skin, especially the increased sensitivity of damaged skin. With the increase in the number of people with sensitive skin, traditional permeation enhancers are more irritating to the skin and are not friendly to people with sensitive skin. Therefore, it is crucial to develop a permeation enhancer product that has a good permeation effect but is non-irritating and safe to use.

[0003] Chinese invention patent CN115770196B discloses a multi-effect whitening and anti-freckle skin care product, its preparation method and its application, which uses natural plant penetration enhancers such as tetrahydropiperine to promote nicotinamide to block the transport of melanin from the basal layer to the stratum corneum, encapsulates salicylic acid to promote stratum corneum exfoliation, and accelerates pigment metabolism, but requires multiple whitening ingredients to work together, and the preparation steps are cumbersome. Chinese invention patent CN117860635B discloses a plant-extracted whitening and anti-freckle composition and its preparation method, which prepares curcumin-tetrahydropiperine co-loaded liposomes, encapsulates whitening components, reduces tyrosinase activity, reduces irritation, and thus reduces the amount of melanin synthesis, but the preparation cost of the liposomes is high and the process is cumbersome. Summary of the invention

[0004] In order to develop a penetration-promoting product that has good penetration-promoting effect but is non-irritating and safe to use, the first aspect of the present invention provides a penetration-promoting composition, including glycol, aminoglucan, and plant extract, wherein the weight ratio of the plant extract, glycol, and aminoglucan is (0.01-0.1):(1-5):(0.5-3).

[0005] As a preferred embodiment, the aminodextran is hydrolyzed glucosaminoglycan.

[0006] As a preferred embodiment, the diol is at least one selected from ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,6-hexanediol, 1,3-hexanediol, 1,3-butanediol, 2,3-butanediol, and pentanediol.

[0007] As a preferred embodiment, the plant extract is selected from at least one of capsaicin, tetrahydropiperine (COSMOPERINE CH), gingerol, gingerol, spilanthol, Centella asiatica extract, Portulaca oleracea extract and tea extract.

[0008] As a preferred embodiment, the diol is one or a combination of 2,3-butanediol and 1,3-propylene glycol, and the plant extract is one or a combination of several selected from capsaicin, gingerol, gingerol and tetrahydropiperine.

[0009] As a preferred embodiment, the diol is 2,3-butanediol; and the plant extract is tetrahydropiperine.

[0010] As a preferred embodiment, the weight ratio of the plant extract, diol and aminodextran is (0.03-0.1):(1.5-2.5):(0.5-2).

[0011] As a preferred embodiment, the weight ratio of the plant extract, diol and aminodextran is 0.1:2:0.5.

[0012] The inventors found during the experiment that the combination of tetrahydropiperine, 2,3-butanediol, and hydrolyzed glycosaminoglycans can significantly improve the inhibition rate of whitening components on melanin. The possible reasons are speculated to be: the combination of tetrahydropiperine, 2,3-butanediol, and hydrolyzed glycosaminoglycans has an excellent effect on promoting cell penetration, 2,3-butanediol has a good dissolving effect on whitening components, and can lock moisture on the skin surface after being used on the skin, so that the whitening components can have a good residence effect on the skin surface. The combination of 2,3-butanediol and tetrahydropiperine can promote the whitening composition to quickly achieve the effect inside the skin, and under the action of hydrolyzed glycosaminoglycans, the irritation of the whitening components to the skin can be reduced, and the acceptable concentration of the whitening components on the skin can be increased, thereby significantly improving the whitening effect. The hydrolyzed glycosaminoglycan introduced in the present invention has a moderate molecular weight and is a precursor of physiological hyaluronic acid synthesized by organisms. It can increase the hydration of the skin and can better help the active ingredients penetrate the gaps between keratinocytes to reach the dermis, increase transdermal penetration and expand the intercellular domain to further achieve better absorption of the active ingredients. The combination of tetrahydropiperine, 2,3-butanediol, and hydrolyzed glycosaminoglycan can achieve good absorption of the active ingredients at low concentrations. High concentrations of effective components may cause protein coagulation, which in turn reduces skin permeability. The combination of the present application promotes penetration at low concentrations of effective components, can achieve the effect of high concentrations, has better cost-effectiveness, and is safer to use.

[0013] The applicant further discovered that the combination of tetrahydropiperine, 2,3-butanediol, and hydrolyzed glycosaminoglycans in a weight ratio of 0.1:2:0.5 can achieve the best penetration effect. The reason may be that at the preferred weight ratio, the pathways on the skin surface are active and the maximum penetration effect is achieved. If the weight ratio exceeds the preferred ratio, the penetration effect will cause irritation to the skin, which will lead to a decrease in the penetration effect.

[0014] The second aspect of the present invention provides a method for preparing a penetration-promoting composition, comprising the following steps: mixing plant extracts, diols, and aminodextran at 30-40° C. to obtain.

[0015] The third aspect of the present invention provides an application of a penetration-promoting composition for use in the preparation of whitening products.

[0016] As a preferred embodiment, the raw materials of the whitening product further include a whitening component, and the whitening component is selected from at least one of niacinamide, 4-n-butylresorcinol, and phenethylresorcinol.

[0017] As a preferred embodiment, the concentration of niacinamide in the whitening product is 0.5-2 g / L; the concentration of 4-n-butylresorcinol in the whitening product is 5-10 g / L.

[0018] As a preferred embodiment, the concentration of niacinamide in the whitening product is 0.5 g / L, 1 g / L, 2 g / L, 3 g / L, and 4 g / L. The concentration of 4-n-butylresorcinol in the whitening product is 5 g / L, 6 g / L, 7 g / L, 8 g / L, 9 g / L, and 10 g / L.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] (1) The penetration-promoting composition of the present invention, which uses a combination of tetrahydropiperine, 2,3-butanediol, and hydrolyzed glycosaminoglycan, can significantly increase the inhibition rate of whitening components on melanin and has a better penetration effect on the skin.

[0021] (2) The penetration-promoting composition of the present invention, tetrahydropiperine, 2,3-butylene glycol, and hydrolyzed glycosaminoglycan are combined in a weight ratio of 0.1:2:0.5, which can achieve the best penetration effect and will not cause skin irritation.

[0022] (3) The penetration-promoting composition of the present invention works together with the whitening component to prepare a whitening product with significant whitening effect and a high inhibition rate of melanin.

[0023] (4) The penetration-promoting composition of the present invention works together with the whitening component to prepare a whitening product that improves the whitening effect without causing skin irritation and is highly safe to use.

[0024] (5) The penetration-promoting composition of the present invention, when used together with 4-n-butylresorcinol or niacinamide, can achieve a melanin inhibition rate of more than 30% without causing irritation to the skin. DETAILED DESCRIPTION

[0025] Hydrolyzed glycosaminoglycan was purchased from D FACTOR of Shanghai Yiheng Chemical.

[0026] Tetrahydropiperine was purchased from Cosmoperine CH of Shanghai Jiuqian Chemical. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a fluorescence test chart of the penetration effect of the penetration-enhancing composition prepared in Example 13 on the skin;

[0028] Figure 2 This is a fluorescence test chart of the penetration effect of the penetration-enhancing composition prepared in Example 14 on the skin;

[0029] Figure 3 This is a fluorescence test chart of the penetration effect of the penetration-enhancing composition prepared in Example 18 on the skin;

[0030] Figure 4 This is a fluorescence test chart of the penetration effect of the penetration-enhancing composition prepared in Example 25 on the skin;

[0031] Figure 5 This is a fluorescence test chart of the penetration effect of the penetration-enhancing composition prepared in Example 26 on the skin;

[0032] Figure 6 This is a test diagram of fish embryos for the melanin inhibition effect of Application Example 2;

[0033] Figure 7 This is a test diagram of fish embryos for the melanin inhibition effect of Example 6;

[0034] Figure 8 This is a test diagram of fish embryos for the melanin inhibition effect of Example 8;

[0035] Fig. 9 This is a test diagram of fish embryos for the melanin inhibition effect of Example 12;

[0036] Fig.10 This is a test diagram of fish embryos for the melanin inhibition effect of Example 17;

[0037] Fig.11This is a test diagram of fish embryos showing the melanin inhibitory effect of Example 19.

[0038] Example 1

[0039] A penetration-promoting composition comprises 1,3-propylene glycol with a mass concentration of 5% and deionized water supplemented to 100%.

[0040] A method for preparing a penetration-promoting composition comprises the following steps: dissolving raw materials in deionized water at 35°C to obtain.

[0041] Example 2

[0042] The invention discloses a penetration-promoting composition, comprising hydrolyzed glycosaminoglycan with a mass concentration of 3% and supplemented with deionized water to 100%.

[0043] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0044] Example 3

[0045] A penetration-promoting composition comprises hydrolyzed glycosaminoglycan with a mass concentration of 1.5% and deionized water supplemented to 100%.

[0046] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0047] Example 4

[0048] The invention discloses a penetration-promoting composition, comprising hydrolyzed glycosaminoglycan with a mass concentration of 0.5% and supplemented with deionized water to 100%.

[0049] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0050] Example 5

[0051] The invention discloses a penetration-promoting composition, comprising hydrolyzed glycosaminoglycan with a mass concentration of 0.3% and supplemented with deionized water to 100%.

[0052] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0053] Example 6

[0054] A penetration-promoting composition comprises hydrolyzed glycosaminoglycan with a mass concentration of 0.15% and deionized water supplemented to 100%.

[0055] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0056] Example 7

[0057] A penetration-promoting composition comprises tetrahydropiperine with a mass concentration of 0.5% and deionized water supplemented to 100%.

[0058] A preparation method of a penetration-promoting composition comprises the following steps: dissolving tetrahydropiperine with dimethyl sulfoxide, and then supplementing and diluting with deionized water to a mass concentration of 0.5%.

[0059] Example 8

[0060] A penetration-promoting composition comprises tetrahydropiperine with a mass concentration of 0.1% and deionized water supplemented to 100%.

[0061] A preparation method of a penetration-promoting composition comprises the following steps: dissolving tetrahydropiperine with dimethyl sulfoxide, and then supplementing and diluting with deionized water to a mass concentration of 0.1%.

[0062] Example 9

[0063] A penetration-promoting composition comprises tetrahydropiperine with a mass concentration of 0.03% and deionized water supplemented to 100%.

[0064] A preparation method of a penetration-promoting composition comprises the following steps: dissolving tetrahydropiperine with dimethyl sulfoxide, and then supplementing and diluting with deionized water to a mass concentration of 0.03%.

[0065] Example 10

[0066] A penetration-promoting composition comprises tetrahydropiperine with a mass concentration of 0.01% and deionized water supplemented to 100%.

[0067] A preparation method of a penetration-promoting composition comprises the following steps: dissolving tetrahydropiperine with dimethyl sulfoxide, and then supplementing and diluting with deionized water to a mass concentration of 0.01%.

[0068] Embodiment 11

[0069] A penetration-promoting composition comprises 2,3-butanediol with a mass concentration of 5% and deionized water supplemented to 100%.

[0070] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0071] Example 12

[0072] A penetration-promoting composition comprises 2,3-butanediol with a mass concentration of 2% and deionized water supplemented to 100%.

[0073] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0074] Embodiment 13

[0075] A penetration-promoting composition comprises, by weight percentage, 0.1% tetrahydropiperine, 2% 2,3-butanediol, and deionized water supplemented to 100%.

[0076] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0077] Embodiment 14

[0078] A penetration-promoting composition comprises, by weight percentage, 0.03% tetrahydropiperine, 2% 2,3-butanediol, and deionized water supplemented to 100%.

[0079] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0080] Embodiment 15

[0081] A penetration-promoting composition comprises, by weight percentage, 0.01% tetrahydropiperine, 2% 2,3-butanediol, and deionized water supplemented to 100%.

[0082] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0083] Example 16

[0084] A penetration-promoting composition comprises, by weight percentage, 0.1% tetrahydropiperine, 2% 2,3-butanediol, 3% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0085] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0086] Embodiment 17

[0087] A penetration-promoting composition comprises, by weight percentage, 0.1% tetrahydropiperine, 2% 2,3-butanediol, 1.5% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0088] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0089] Embodiment 18

[0090] A penetration-promoting composition comprises, by weight percentage, 0.1% tetrahydropiperine, 2% 2,3-butanediol, 0.5% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0091] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0092] Embodiment 19

[0093] A penetration-promoting composition comprises, by weight percentage, 0.03% tetrahydropiperine, 2% 2,3-butanediol, 3% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0094] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0095] Embodiment 20

[0096] A penetration-promoting composition comprises, by weight percentage, 0.03% tetrahydropiperine, 2% 2,3-butanediol, 1.5% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0097] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0098] Embodiment 21

[0099] A penetration-promoting composition comprises, by weight percentage, 0.03% tetrahydropiperine, 2% 2,3-butanediol, 0.5% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0100] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0101] Embodiment 22

[0102] A penetration-promoting composition comprises, by weight percentage, 0.01% tetrahydropiperine, 2% 2,3-butanediol, 3% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0103] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0104] Embodiment 23

[0105] A penetration-promoting composition comprises, by weight percentage, 0.01% tetrahydropiperine, 2% 2,3-butanediol, 1.5% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0106] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0107] Embodiment 24

[0108] A penetration-promoting composition comprises, by weight percentage, 0.01% tetrahydropiperine, 2% 2,3-butanediol, 0.5% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0109] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0110] Embodiment 25

[0111] A penetration-promoting composition comprises, by weight percentage, 0.1% tetrahydropiperine, 2% 2,3-butanediol, 0.5% hyaluronic acid, and deionized water supplemented to 100%.

[0112] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0113] Embodiment 26

[0114] A penetration-promoting composition comprises, by weight percentage, 0.1% capsaicin, 2% 2,3-butanediol, 0.5% hydrolyzed glycosaminoglycan, and deionized water supplemented to 100%.

[0115] The preparation method of a penetration-promoting composition is the same as that of Example 1.

[0116] Application Example 1

[0117] An application of a penetration-promoting composition, the penetration-promoting composition prepared in Example 18 was diluted to 5 g / L using fish embryo culture medium, and the melanin inhibition rate was tested.

[0118] Application Example 2

[0119] An application of a penetration-promoting composition, the penetration-promoting composition prepared in Example 18 was diluted to 10 g / L using fish embryo culture medium, and the melanin inhibition rate was tested.

[0120] Application Example 3

[0121] An application of a penetration-promoting composition, the penetration-promoting composition prepared in Example 19 was diluted to 5 g / L using fish embryo culture medium, and the melanin inhibition rate was tested.

[0122] Application Example 4

[0123] An application of a penetration-promoting composition, the penetration-promoting composition prepared in Example 19 was diluted to 10 g / L using fish embryo culture medium, and the melanin inhibition rate was tested.

[0124] Application Example 5

[0125] A whitening component is prepared by diluting a solution of 0.1% by mass of 4-n-butylresorcinol to 5 g / L using fish embryo culture medium to test the melanin inhibition rate.

[0126] Application Example 6

[0127] A whitening component is prepared by diluting a solution of 0.1% 4-n-butylresorcinol by mass to 10 g / L using fish embryo culture medium to test the melanin inhibition rate.

[0128] Application Example 7

[0129] An application of a penetration-promoting composition is to mix the penetration-promoting composition prepared in Example 18 with a solution of 0.1% by mass of 4-n-butylresorcinol, and then dilute it to 5 g / L with fish embryo culture medium. The melanin inhibition rate is tested.

[0130] Application Example 8

[0131] An application of a penetration-promoting composition is to mix the penetration-promoting composition prepared in Example 18 with a solution of 0.1% by mass of 4-n-butylresorcinol, and then dilute it to 10 g / L with fish embryo culture medium. The melanin inhibition rate is tested.

[0132] Application Example 9

[0133] An application of a penetration-promoting composition is to mix the penetration-promoting composition prepared in Example 19 with a solution of 0.1% by mass of 4-n-butylresorcinol, and then dilute it to 10 g / L with fish embryo culture medium. The melanin inhibition rate is tested.

[0134] Application Example 10

[0135] A whitening component is prepared by diluting 100% nicotinamide by mass to 4 g / L with fish embryo culture medium to test the melanin inhibition rate.

[0136] Application Example 11

[0137] A whitening component is prepared by diluting 100% nicotinamide by mass to 3 g / L with fish embryo culture medium to test the melanin inhibition rate.

[0138] Application Example 12

[0139] A whitening component is prepared by diluting 100% nicotinamide by mass to 2 g / L with fish embryo culture medium to test the melanin inhibition rate.

[0140] Application Example 13

[0141] A whitening component, niacinamide is diluted to 1g / L with fish embryo culture medium, and the melanin inhibition rate is tested.

[0142] Application Example 14

[0143] A whitening component, niacinamide is diluted to 0.5g / L with fish embryo culture medium, and the melanin inhibition rate is tested.

[0144] Application Example 15

[0145] An application of a penetration-promoting composition, the penetration-promoting composition prepared in Example 18 and nicotinamide are mixed, and then diluted with fish embryo culture medium, the concentration of the penetration-promoting composition is 10 g / L, and the concentration of nicotinamide is 4 g / L. The melanin inhibition rate is tested.

[0146] Application Example 16

[0147] An application of a penetration-enhancing composition, the penetration-enhancing composition prepared in Example 18 and nicotinamide were mixed, and then diluted with fish embryo culture medium, the concentration of the penetration-enhancing composition was 10 g / L, and the concentration of nicotinamide was 3 g / L. The melanin inhibition rate was tested.

[0148] Application Example 17

[0149] An application of a penetration-promoting composition, the penetration-promoting composition prepared in Example 18 and nicotinamide are mixed, and then diluted with fish embryo culture medium, the concentration of the penetration-promoting composition is 10 g / L, and the concentration of nicotinamide is 2 g / L. The melanin inhibition rate is tested.

[0150] Application Example 18

[0151] An application of a penetration-enhancing composition, the penetration-enhancing composition prepared in Example 18 and nicotinamide were mixed, and then diluted with fish embryo culture medium, the concentration of the penetration-enhancing composition was 10 g / L, and the concentration of nicotinamide was 1 g / L. The melanin inhibition rate was tested.

[0152] Application Example 19

[0153] An application of a penetration-promoting composition, the penetration-promoting composition prepared in Example 18 and nicotinamide are mixed, and then diluted with fish embryo culture medium, the concentration of the penetration-promoting composition is 10 g / L, and the concentration of nicotinamide is 0.5 g / L. The melanin inhibition rate is tested.

[0154] Performance Testing

[0155] 1. Skin permeability:

[0156] Fish embryo culture medium: 2940 mg of anhydrous calcium chloride, 1233 mg of magnesium sulfate heptahydrate, 630 mg of sodium bicarbonate, and 55 mg of potassium chloride were weighed and dissolved in 10 L of water. The penetration-enhancing compositions of Examples 1-26 were diluted 10 times with the fish embryo solution and tested.

[0157] Twenty three-day-old zebrafish embryos were exposed to 0.5 g / L sodium fluorescein solution and diluted solution of the embodiment as the experimental group, and 20 three-day-old zebrafish embryos were exposed to 0.5 g / L sodium fluorescein solution as the blank control group. After exposure for 2 hours, the fish embryos were anesthetized and the fluorescence intensity of the tail was measured by fluorescence photography. The test results of the reference zebrafish embryo skin penetration test method are shown in Table 1.

[0158] 0.5g / L fluorescein sodium solution: Weigh 0.5g of fluorescein sodium powder and prepare it into 0.5g / L using fish embryo culture medium.

[0159] Table 1

[0160]

[0161]

[0162] 2. Melanin inhibition rate: 20 8-hour-old zebrafish embryos were exposed to the sample solution of the application example, and a blank control group, a 100% melanin inhibition model group (30 mg / L phenylthiourea) and a positive control group (2.5 g / L kojic acid) were set up. After 48 hours of exposure, the fish embryos were photographed under a microscope to measure the melanin signal intensity and perform statistical analysis. Refer to T / SHRH 036-2021 "Cosmetic Melanin Inhibition Test-Zebrafish Embryo Test Method" for test results, see Table 2.

[0163] Fish embryo culture medium: weigh 2940 mg of anhydrous calcium chloride, 1233 mg of magnesium sulfate heptahydrate, 630 mg of sodium bicarbonate, and 55 mg of potassium chloride and dissolve them in 10 L of water to prepare the medium.

[0164] Blank control group: fish embryo culture medium.

[0165] 30mg / L phenylthiourea: weigh 15mg of phenylthiourea and dissolve it in 10mL of water, then dilute it 50 times with fish embryo culture medium.

[0166] 2.5g / L Kojic Acid: Weigh 2.5g of kojic acid and dissolve it in 1000mL of water.

[0167] Table 2

[0168]

[0169]

Claims

1. A penetration-promoting composition, characterized in that The invention comprises dihydric alcohol, aminoglucan and plant extract, wherein the weight ratio of the plant extract, dihydric alcohol and aminoglucan is (0.01-0.1):(1-5):(0.5-3).

2. The penetration-promoting composition according to claim 1, characterized in that The aminodextran is hydrolyzed glucosaminoglycan.

3. The penetration-promoting composition according to claim 1, characterized in that The diol is at least one selected from ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,6-hexanediol, 1,3-hexanediol, 1,3-butanediol, 2,3-butanediol, and pentanediol.

4. The penetration-promoting composition according to claim 3, characterized in that The plant extract is selected from at least one of capsaicin, gingerol, gingerol, spilanthol, Centella asiatica extract, Portulaca oleracea extract, tea extract and tetrahydropiperine.

5. The penetration-promoting composition according to claim 4, characterized in that The diol is selected from 2,3-butanediol, 1,3-propylene glycol, or a combination of two thereof; the plant extract is selected from capsaicin, gingerol, gingerol, and tetrahydropiperine, or a combination of several thereof.

6. The penetration-promoting composition according to claim 1, characterized in that: The weight ratio of the plant extract, diol and aminoglucan is (0.03-0.1):(1.5-2.5):(0.5-2).

7. A method for preparing the penetration-promoting composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: The plant extract, glycol and aminodextran are mixed at 30-40° C. to obtain.

8. An application of the penetration-promoting composition according to any one of claims 1 to 6, characterized in that: Used in the preparation of whitening products.

9. The use of the penetration-promoting composition according to claim 8, characterized in that: The raw materials of the whitening product also include whitening components, and the whitening components are selected from at least one of nicotinamide, 4-n-butylresorcinol, and phenethylresorcinol.

10. The use of the penetration-promoting composition according to claim 9, characterized in that: The concentration of the nicotinamide in the whitening product is 0.5-2 g / L; the concentration of the 4-n-butylresorcinol in the whitening product is 5-10 g / L.

Images