Method for inhibiting premature delivery or shortening delivery process of sows and application

Abstract

The invention provides a method for inhibiting premature delivery of sows or shortening the delivery process and application, and particularly discloses a method for inhibiting premature delivery of sows and shortening the delivery process of sows by using vitamin B6 or a derivative thereof and application. Aiming at the perinatal period problem of low survival rate of newborn piglets caused by long premature delivery or delivery birth process of sows, the vitamin B6 or the derivative thereof is applied to the sows at the end of pregnancy, and the result shows that the vitamin B6 or the derivative thereof can effectively inhibit the premature delivery of the sows, shorten the delivery birth process of the sows and improve the survival rate of the piglets; the method is an effective method for improving sow delivery and piglet survival, provides great value for promoting batch production and high-efficiency breeding of sows, and has important significance for solving the problem of premature delivery in the perinatal period in the reproductive field.

Description

Technical Field

[0001] The present invention mainly relates to the field of animal perinatal reproduction regulation, and specifically provides a method and application for inhibiting premature birth of sows or shortening the sow's delivery process. The method is based on the continuous administration of vitamin B6 at the end of sow pregnancy to inhibit premature birth of sows, shorten the sow's delivery process, and improve the survival rate of piglets. It provides great value for promoting the efficient breeding of sows in batch production in my country, and is of great significance for solving the problem of perinatal premature birth in the reproductive field. Background Art

[0002] The sow batch production technology is to divide the sow group according to the production plan according to the size of the sow group, supplement the reserve sows according to the production plan, and use biotechnology to make the reserve sows and multiparous sows in the same batch achieve the purpose of synchronous estrus, synchronous mating and synchronous delivery. It is an efficient and controllable management technology system to improve the reproductive performance of the sow group in the pig farm. However, in actual production, due to individual differences in sows, some sows often give birth prematurely, resulting in a low survival rate of piglets and difficulty in achieving the goal of synchronous delivery; in addition, after the sow starts to give birth, the uterus contracts rhythmically. The longer the piglets stay in the sow's uterus or birth canal, the higher the risk of umbilical cord rupture, and the greater the risk of piglet death. Especially in the late stage of sow delivery, the sow's production force is insufficient, the uterus is weak, and the piglets with broken umbilical cords cannot be delivered in time, resulting in an increased risk of suffocation and death. Therefore, it is necessary to provide effective solutions to the above-mentioned perinatal problems of sows.

[0003] Some existing delivery control technologies can induce delivery, but have no significant effect on the delivery process of sows; and although the combined use of certain drugs can induce concentrated delivery in sows, it is easy to lead to prolonged delivery and an increase in the number of stillbirths. In addition, the number of live piglets and the live piglet rate also have a downward trend. The application scope of existing delivery control technologies is sows that are due to give birth, but there is no room for premature sows. In response to the problem of premature delivery in sows, the current method used in production is to feed allylprogesterone, but feeding allylprogesterone often leads to late delivery and prolonged delivery of sows, and the price of allylprogesterone is relatively high. In view of the above reasons, the pig farming industry is in urgent need of a delivery control solution that is simple to operate, efficient and inexpensive to inhibit premature delivery in sows and shorten the delivery process of sows.

[0004] Vitamin B6 is a water-soluble B vitamin that exists in the body in the form of pyridoxine, pyridoxal, pyridoxamine, pyridoxine phosphate, pyridoxal phosphate, and pyridoxamine phosphate. It participates in key biochemical processes such as amino acid metabolism and neurotransmitter synthesis, and has physiological functions such as anti-inflammatory, antioxidant, neuromodulatory, and anti-tumor. It is essential for maintaining the health of the nervous system, skin health, and immune function. However, to date, there have been no reports or suggestions on the use of vitamin B6 to inhibit premature birth in sows, shorten the delivery process of sows, and improve the survival rate of piglets. Summary of the invention

[0005] The present invention has conducted a large number of creative experiments to compare the effects of applying vitamin B6 to batch sows and natural delivery. The results show that the application of vitamin B6 to sows in the late pregnancy can effectively inhibit sow premature delivery, shorten the sow delivery process, and increase the live piglet rate, thereby establishing a method for improving the delivery effect of batch sows, which provides important value for the promotion and application of sow batch production. Specifically, the present invention includes the following contents.

[0006] A first aspect of the present invention provides a method for inhibiting premature birth in sows, shortening their parturition process and / or improving the survival rate of piglets, which comprises the step of administering vitamin B6 or a derivative thereof to the sow.

[0007] In certain embodiments, the method for inhibiting premature birth of sows, shortening the delivery process and / or improving the survival rate of piglets according to the present invention comprises the following steps:

[0008] (1) Sows are bred at the same time, followed by pregnancy tests, pregnancy confirmation, and then transferred to the farrowing house;

[0009] (2) Administering vitamin B6 or its derivatives to sows at the end of pregnancy, and the daily dosage of the vitamin B6 or its derivatives is in the range of 1-20 mg / Kg.BW.

[0010] In certain embodiments, according to the method of inhibiting premature birth in sows, shortening their delivery process and / or improving the survival rate of piglets described in the present invention, the daily dosage of vitamin B6 or its derivatives is in the range of 1-20 mg / Kg.BW.

[0011] In certain embodiments, according to the method of inhibiting premature birth, shortening the delivery process and / or improving the survival rate of piglets in sows according to the present invention, vitamin B6 or its derivatives are administered to the sow daily 1-30 days before delivery.

[0012] In certain embodiments, according to the method of inhibiting premature birth, shortening the delivery process and / or improving the survival rate of piglets in sows according to the present invention, vitamin B6 or its derivatives are administered to the sow daily 1-14 days before delivery.

[0013] In certain embodiments, according to the method of the present invention for inhibiting premature birth of sows, shortening their farrowing process and / or improving the survival rate of piglets, the administration method is oral or injection.

[0014] In certain embodiments, according to the method of inhibiting premature birth, shortening the delivery process and / or improving the survival rate of piglets in sows according to the present invention, vitamin B6 or its derivatives are administered continuously every day from 84 to 114 days of gestation.

[0015] The second aspect of the present invention provides the use of vitamin B6 or its derivatives or the method or composition described in the present invention in the perinatal reproduction regulation of animals, wherein the use includes inhibiting premature birth of sows, shortening the sow's labor process and / or improving the survival rate of sows' piglets.

[0016] The present invention aims at the perinatal problem of low survival rate of newborn piglets caused by premature birth or long delivery of sows. Vitamin B6 is administered to sows in the late pregnancy. The results show that it can effectively inhibit premature birth of sows, shorten the delivery process of sows, and improve the survival rate of piglets. It is an effective method for improving sow delivery and improving piglet survival, provides great value for promoting sow batch production and high-efficiency breeding, and is of great significance for solving the perinatal premature birth problem in the reproductive field. DETAILED DESCRIPTION

[0017] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0018] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that the upper and lower limits of the scope and each intermediate value therebetween are specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0019] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as commonly understood by those skilled in the art to which the invention belongs. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0020] The present invention provides a nutrient, a composition and a method for inhibiting premature birth of sows, shortening the delivery process and / or improving the survival rate of piglets. The nutrient or composition contains vitamin B6 or its derivatives, or is composed of them. The present invention also provides the use of vitamin B6 or its derivatives in inhibiting premature birth of sows, shortening the delivery process of sows and improving the survival rate of piglets.

[0021] In the present invention, "vitamin B6" refers to vitamin B6 family compounds, including but not limited to pyridoxine, pyridoxal, pyridoxamine and their phosphates, i.e., pyridoxal phosphate, pyridoxamine phosphate. "Vitamin B6 derivatives" refer to acetals, ketals, organic acid esters, sulfonates, aminosulfonates, aminophosphonates, acetals and hemiacetal compounds of the above vitamin B6 family compounds.

[0022] In a preferred embodiment, the method for inhibiting premature birth or shortening the farrowing process of a sow comprises the following steps:

[0023] (1) Sows are bred at the same time, followed by pregnancy checks to confirm pregnancy, and sows in the late pregnancy are transferred to the farrowing house;

[0024] (2) Administering vitamin B6 or its derivatives to sows at the end of pregnancy, with the daily dosage of the vitamin B6 or its derivatives being in the range of 1-20 mg / kg.BW, so as to inhibit premature birth of sows, shorten the delivery process of sows, and improve the survival rate of piglets.

[0025] In a preferred embodiment, the method of using vitamin B6 to inhibit premature birth in sows, shorten the sow's parturition process, and improve the survival rate of piglets is to continuously administer vitamin B6 or its derivatives every day during 84-114 days of gestation, preferably 84-113 days, and further preferably 100-113 days, for example 100 days, 101 days, 102 days, 103 days, 104, 105 days, 106 days, 107 days, 108 days, 109 days, 110 days, 111 days, 112 days, 113 days, or any range within the above number of days.

[0026] In a preferred embodiment, the daily dosage of vitamin B6 or its derivatives can vary in the range of 1-20 mg / Kg.BW, and the preferred dosage is 2-20 mg / Kg.BW per day, for example 2, 4, 6, 8, 10, 12, 14, 16, 18, 20 mg / Kg.BW, or any range within the above dosages.

[0027] In a preferred embodiment, vitamin B6 or its derivatives are used orally or by injection, preferably by injection. It will be appreciated by those skilled in the art that when administered orally, any suitable oral dosage form of vitamin B6 or its derivatives may be selected, such as soft capsules, tablets, etc. of vitamin B6 or its derivatives. When administered by injection, any suitable liquid dosage form of vitamin B6 or its derivatives may be selected, such as an injection of vitamin B6 or its derivatives.

[0028] In a preferred embodiment, the sow is administered vitamin B6 or a derivative thereof daily 1-30 days before farrowing, preferably 1-14 days before farrowing, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 days.

[0029] The present invention further provides a composition comprising vitamin B6 or a derivative thereof for inhibiting premature birth in sows, shortening the delivery process and / or improving the survival rate of piglets. The composition may further comprise optional additional substances, which are not particularly limited and can be selected as needed. The additional substances may or may not be any suitable agent for inhibiting premature birth in sows, shortening the delivery process and / or improving the survival rate of piglets.

[0030] In the present invention, the additional substances include but are not limited to enzymes, proteins, anti-nutritional factors, polysaccharides or fibers.

[0031] In the present invention, the composition includes optional additives or adjuvants, such as additives or adjuvants used in feed production, examples of which include but are not limited to minerals, preservatives, antibiotics, fermentation products, fats, other essential ingredients, colorants, fillers, etc. Substances that can be added include marine products, calcium hydrogen phosphate, calcium carbonate, calcium hydrogen carbonate, magnesium oxide, multivitamins, minerals or other types of minerals or trace elements, essential amino acids such as lysine, methionine, tryptophan, threonine, and derivatives thereof, or combinations thereof.

[0032] Example

[0033] The following shows the application of vitamin B6 in batch production of sows to inhibit premature birth and shorten the delivery process.

[0034] (1) Experimental methods and grouping

[0035] The large white sows produced in batches were randomly divided into groups, including a natural delivery group and a vitamin B6 group. The sows were multiparous sows with a body weight of 250-270 kg and were fed a daily diet of 2.5-3 kg. During the experiment, the experimental sows in each group were fed regularly according to the feeding and management requirements of the farm and had free access to water. The daily diet fed could adopt the formula used for sows during pregnancy (for example, the formula recommended in "Batch Production Management Technology for Sows") or the components could be adjusted as needed. The nutritional level of the diet used in this embodiment is shown in Table 1 below.

[0036] Table 1 Nutritional levels of sow diets during pregnancy

[0037]

[0038] The specific groups are as follows:

[0039] (a) Natural delivery group: pregnant sows were not treated in any way, and the data of natural delivery and litter size were recorded.

[0040] (b) Vitamin B6-low-dose group: Sows were fed 0.075 g (each) of vitamin B6 every day at 8:00 am from 100 to 113 days of gestation until 113 days before the expected delivery date of the sows.

[0041] (c) Vitamin B6-medium dose group: Sows were fed 0.75 g (per head) of vitamin B6 every day at 8:00 am from 100 to 113 days of gestation until 113 days after the sows' expected farrowing date.

[0042] (d) Vitamin B6-high dose group: Sows were fed 7.5 g (per head) of vitamin B6 per day at 8:00 am from 100 to 113 days of gestation until 113 days before the expected delivery date of the sows.

[0043] (2) Observe and record sow farrowing

[0044] Record the date, time, duration, and farrowing conditions of the sows (including the total number of farrowings, number of live piglets, number of stillbirths, and number of mummies, and calculate the average farrowing process and live piglet rate.

[0045] (3) Statistical analysis

[0046] SPSS 22.0 software (SPSS GmbH, Munich, Germany) was used for one-way ANOVA and chi-square test. The average farrowing process, litter size, and litter live piglets were analyzed by one-way ANOVA and expressed as mean ± standard deviation. Chi-square test was used to analyze the premature birth rate and live piglet rate of sows. P < 0.05 was considered significant.

[0047] (4) Experimental results

[0048] In this embodiment, compared with the control group (natural delivery), feeding appropriate doses of vitamin B6 (medium-dose group and high-dose group) to sows in the late pregnancy can significantly shorten the sow's delivery process, reduce the number of stillbirths, and increase the sow's live piglet rate (Table 2). However, feeding low doses of vitamin B6 has no obvious effect on the sow's delivery process and inhibition of premature birth. The live piglet rate has an increasing trend, but there is no significant difference.

[0049] Table 2 Effects of different synchronous farrowing plans on sow farrowing process and farrowing situation

[0050]

[0051]

[0052] Note: Different lowercase letters on the right shoulder indicate that the indicators in the same row are significantly different among the groups, P<0.05.

[0053] Industrial value of this invention:

[0054] Since the outbreak of African swine fever in August 2018, the traditional continuous production model has been unable to adapt to the rapid development of the pig farming industry. In addition, the entire pig market is facing severe challenges. Sow batch production technology has become an important measure for transformation and upgrading. In the future, the era of small-scale pig farming will become a thing of the past. The emergence of large-scale and batch production methods will inevitably bring earth-shaking changes to the pig farming industry. However, the problems of premature birth, long delivery process and low live piglet rate of sows have seriously affected the economic benefits of pig farms. However, the present invention is a method for improving the sow's delivery effect based on vitamin B6, which effectively improves the live piglet rate of batches of sows. The present invention can increase the live piglets by 70 for every 100 sows. According to the current market price of 350-450 yuan per weaned piglet, the present invention will generate an additional economic value of 24,500-31,500 yuan for every 100 sows. The method has low cost, high efficiency and easy operation, which provides an effective method for reducing costs and increasing efficiency in the pig farming industry. Therefore, the present invention will generate important economic and social value for promoting batch production of sows.

[0055] The present invention solves the problems of premature birth, long labor and low live piglet rate of sows by additionally applying a specific dose of vitamin B6, thereby reducing the number of stillbirths in batches of sows by 0.48 heads and effectively increasing the number of live piglets per litter by 0.7 heads. According to the annual number of litters per sow in China of 2.23 and the survival rate of weaned piglets of 95% in 2024, the PSY will be increased by 0.71*2.23*95%=1.48 heads. Therefore, the present invention is an effective way to improve the quality and efficiency of pig farming. At the same time, the present invention also has the advantages of simplicity, high efficiency, strong innovation, broad industrial prospects and value.

[0056] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A method for inhibiting premature birth or shortening the delivery process of sows, characterized in that: The following steps are involved: (1) Sows are bred at the same time, followed by pregnancy tests, pregnancy confirmation, and then transferred to the farrowing house; (2) Administering vitamin B6 or its derivatives to sows at the end of pregnancy, and the daily dosage of the vitamin B6 or its derivatives is in the range of 1-20 mg / Kg.BW.

2. The method for inhibiting premature birth or shortening the delivery process of sows according to claim 1, characterized in that: Sows are administered vitamin B6 or its derivatives daily 1-30 days before farrowing.

3. The method for inhibiting premature birth or shortening the delivery process of sows according to claim 1, characterized in that: Sows are administered vitamin B6 or its derivatives daily 1-14 days before farrowing.

4. The method for inhibiting premature birth or shortening the delivery process of sows according to claim 1, characterized in that: Vitamin B6 or its derivatives are administered daily continuously from 84 to 114 days of gestation.

5. The method for inhibiting premature birth or shortening the delivery process of sows according to claim 1, characterized in that: The route of administration is oral.

6. The method for inhibiting premature birth or shortening the delivery process of sows according to claim 1, characterized in that: The route of administration is injection.

7. Use of vitamin B6 or its derivatives in inhibiting premature birth and / or shortening sow labor, characterized in that: The sows are bred at the same time, then undergo a pregnancy check to confirm pregnancy, and then are transferred to a farrowing house. Vitamin B6 or a derivative thereof is administered to the sows at the end of pregnancy, and the daily dosage of the vitamin B6 or a derivative thereof is in the range of 1-20 mg / Kg.BW, so as to inhibit premature birth and / or shorten the sow's labor process.

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