Female genital tract antibacterial preparation and preparation method thereof

Abstract

The invention provides a female genital tract antibacterial preparation and a preparation method thereof, and relates to the technical field of antibacterial preparations. Comprising the following components: 1-3 parts of fructus cnidii, 2-3 parts of cortex phellodendri, 1-5 parts of cortex dictamni, 0.3-0.5 part of mint, 1-3 parts of radix sophorae flavescentis, 1-3 parts of peach kernel, 1-3 parts of honeysuckle, 0.1-0.3 part of radix salviae miltiorrhizae, 0.1-0.3 part of safflower, 7-9 parts of aloe, 5-7 parts of China rose, 1-3 parts of cowherb seed, 2-4 parts of motherwort, 1-5 parts of polyhexamethylene biguanide and 9-11 parts of a relieving preparation. The liquorice and the saffron crocus play a role, the liquorice has antibacterial and antiviral effects, harmonizes the medicines and can enhance the curative effect of other medicines, and the saffron crocus helps resist damage of free radicals, retard cell aging, regulate an immune system and control the immune system of the human body to control diseases, so that the irritation of the human body to the medicines is small, and the occurrence of allergy conditions is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of antibacterial preparations, and in particular to an antibacterial preparation for female reproductive tract and a preparation method thereof. Background Art

[0002] Female genital tract antimicrobial preparations are drugs used to prevent and treat infections of the female reproductive system. These drugs are usually used to treat bacterial infections of the vagina, cervix, or other parts of the reproductive tract.

[0003] Existing female reproductive tract antibacterial preparations are purified by drugs to control inflammation when used. This method can control inflammation very well, but because it is all controlled by drugs, it cannot regulate the immune system and control the body's own immune system to control the disease. This will cause the human body to be overly irritated by the drugs, which may cause allergies. Therefore, we provide a female reproductive tract antibacterial preparation and a preparation method thereof. Summary of the invention

[0004] The purpose of the present invention is to solve the shortcomings existing in the prior art.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A female reproductive tract antibacterial preparation comprises the following components: 1-3 parts of cnidium monnieri, 2-3 parts of phellodendron amurense, 1-5 parts of dactylic acid cortex, 0.3-0.5 parts of mint, 1-3 parts of sophora flavescens, 1-3 parts of peach kernel, 1-3 parts of honeysuckle, 0.1-0.3 parts of salvia miltiorrhiza, 0.1-0.3 parts of safflower, 7-9 parts of aloe, 5-7 parts of rose, 1-3 parts of fenugreek, 2-4 parts of motherwort, 1-5 parts of polyhexamethylene biguanide and 9-11 parts of relief preparation.

[0007] By adopting the above technical solution: the relief preparation includes: 1-3 parts of probiotics, 3-5 parts of Rhodiola rosea, 2-4 parts of licorice, and 0.5-0.7 parts of saffron;

[0008] The preparation method of the relief preparation comprises the following steps:

[0009] (1) Grinding the dried raw materials of licorice and saffron into coarse powder respectively;

[0010] (2) Select 70% ethanol as the extraction solvent, put the crude powder of Rhodiola rosea, licorice and saffron into the extractor at a mass ratio of 1:5 to 1:10 to the solvent, and soak for 24 hours;

[0011] (3) heating the soaked solution to 60-80° C. and performing heating reflux extraction for 1-2 hours. After the extraction solution is heated, use a filter screen or filter cloth to remove the herbal residue to obtain a crude extract;

[0012] (4) using a rotary evaporator or a reduced pressure evaporation method to concentrate the solvent in the crude extract to a small volume, and the concentrated extract can be further processed by spray drying or freeze drying to obtain a dry powder;

[0013] (5) Using ethanol to extract the concentrated liquid of the effective components of Rhodiola rosea, spraying the Rhodiola rosea solution on the surface of the above powder by spray drying, drying, and finally adding probiotics.

[0014] A method for preparing a female reproductive tract antibacterial preparation comprises the following steps:

[0015] S1. Herbal extraction;

[0016] S2, dissolution of polyhexamethylene biguanide;

[0017] S3, synthetic matrix;

[0018] S4, formula mixing;

[0019] S5. Quality control;

[0020] S6. Packaging.

[0021] By adopting the above technical scheme: in the step S1: Cnidium monnieri, Phellodendron amurense and mint are extracted by alcohol extraction, and fresh peel, Sophora flavescens, peach kernel, honeysuckle, Salvia miltiorrhiza, safflower, aloe, rose, Vaccaria segetalis, Leonurus japonicus and polyhexamethylene biguanide are extracted by water extraction, and the extraction is preserved for later use.

[0022] By adopting the above technical solution: the dissolution of polyhexamethylene biguanide in step S2 comprises the following steps:

[0023] S21, calculating the amount of polyhexamethylene biguanide;

[0024] S22, select solvent: use deionized water;

[0025] S23, dissolving hexamethylene biguanide: adding the calculated polyhexamethylene biguanide into deionized water, stirring with a stirrer, and setting aside for later use.

[0026] By adopting the above technical solution: in step S3, the matrix synthesized by adding glycerol, polyvinyl alcohol and carbomer into a stirrer for stirring to form a gel for later use.

[0027] By adopting the above technical solution: in step S4, the reserved materials of steps S1, S2 and S3 are mixed, and the mitigation preparation is added and mixed, and stirred until there are no bubbles or precipitation.

[0028] By adopting the above technical solution: during the quality control in step S5:

[0029] Conduct a pH test: Make sure the pH value of the product is between 4.5-5.5;

[0030] Microbiological testing: ensuring that the preparation does not contain any harmful microorganisms;

[0031] Antibacterial activity test: The antibacterial effect of the preparation is confirmed through bacterial inhibition experiments, etc.

[0032] Compared with the prior art, the advantages and positive effects of the present invention are:

[0033] The present invention discloses that rhodiola rosea can stimulate the activity of the immune system, enhance the defense capability against pathogens, and can help alleviate the symptoms caused by inflammation, especially when the immune system is overactivated. When other drugs are used to treat the cause of the disease, rhodiola rosea is located outside the relief preparation, and can relieve the symptoms caused by inflammation when the immune system is overactivated, enhance the defense capability against pathogens, and alleviate the patient's own condition. Licorice and saffron are in effect. Licorice has antibacterial and antiviral effects, can inhibit the growth of various pathogenic microorganisms, coordinate the effects of various drugs, can enhance the efficacy of other drugs, and reduce side effects at the same time. It also has a strong anti-inflammatory effect, can inhibit the generation of inflammatory mediators, and alleviate inflammation caused by infection or other reasons. Saffron helps resist the damage of free radicals, slows down cell aging, can resist inflammation, regulate the nervous system, improve skin health, slow down skin aging, minimize the damage caused by illness, can regulate the immune system, and control the immune system of the body to control the disease, so that the human body is less irritated by the drugs, and the current allergic situation is reduced.

[0034] Through the combination of multiple ingredients, various vaginal problems can be comprehensively regulated. Probiotics can help restore the normal flora in the vagina, inhibit the growth of pathogenic bacteria, and prevent the recurrence of infectious diseases such as vaginitis. The use of probiotics can supplement the insufficient regulation of microecological balance in traditional Chinese medicine treatment;

[0035] Through combined use, it may be possible to cover a wider range of pathogens and improve efficacy. The blood-activating and blood-stasis-removing effects of safflower and peach kernel can also help improve blood circulation and promote local recovery. Its comprehensive regulation and comprehensive treatment characteristics can enhance immunity, regulate microecology, activate blood circulation and remove blood stasis. It can better adapt to vaginal problems caused by different causes, reduce side effects and improve efficacy. DETAILED DESCRIPTION

[0036] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] Example 1

[0038] The present invention provides a technical solution: an antibacterial preparation for female reproductive tract and a preparation method thereof, comprising the following components: 1 part of Cnidium monnieri, 2 parts of Phellodendron amurense, 1 part of Dictamni cortex, 0.3 parts of Mentha arvense, 1 part of Sophora flavescens, 1 part of Prunus persica, 1 part of Honeysuckle, 0.1 part of Salvia miltiorrhiza, 0.1 part of Carthamus tinctorius, 7 parts of Aloe vera, 5 parts of Rose, 1 part of Vaccaria segetalis, 2 parts of Leonurus japonicus, 1 part of Polyhexamethylene biguanide and 9 parts of relief preparation;

[0039] The relief preparation comprises: 1 part of probiotics, 3 parts of Rhodiola rosea, 2 parts of liquorice, and 0.5 parts of saffron.

[0040] The preparation method of the relief preparation comprises the following steps:

[0041] (1) Grinding the dried raw materials of licorice and saffron into coarse powder respectively to increase the surface area to improve the extraction efficiency. The powder can be sieved as needed to ensure uniform particles;

[0042] (2) Select 70% ethanol as the extraction solvent, which can better extract water-soluble and fat-soluble components at the same time. The mass ratio of the crude powder of Rhodiola rosea, licorice and saffron to the solvent is between 1:5 and 1:10, put them in the extractor and soak for 24 hours;

[0043] (3) The soaked solution is heated to 60-80° C. and subjected to heating reflux extraction for 1-2 hours. After the extraction solution is heated, the herbal residue is removed using a filter screen or filter cloth to obtain a crude extract. During the heating process, a reactor, a reflux device or an extraction tower can be used to ensure that the active ingredients are extracted to the greatest extent possible.

[0044] (4) using a rotary evaporator or a reduced pressure evaporation method to concentrate the solvent in the crude extract to a small volume. This process can be carried out at a low temperature to avoid the influence of the volatile components of the solvent on the active ingredients. The concentrated extract can be further processed by spray drying or freeze drying to obtain a dry powder;

[0045] (5) Using ethanol to extract the concentrated liquid of the effective components of Rhodiola rosea, spraying the Rhodiola rosea solution on the surface of the above powder by spray drying, drying, and finally adding probiotics.

[0046] Rhodiola rosea can stimulate the activity of the immune system, enhance the defense against pathogens, and help relieve symptoms caused by inflammation, especially when the immune system is overactivated. When other drugs are treating the cause of the disease, Rhodiola rosea is located outside the relief preparation, which can relieve the symptoms caused by inflammation when the immune system is overactivated, enhance the defense against pathogens, and relieve the patient's own condition. Licorice and saffron are working. Licorice has antibacterial and antiviral effects, can inhibit the growth of a variety of pathogenic microorganisms, coordinate the effects of various medicines, can enhance the efficacy of other drugs, and reduce side effects. It also has a strong anti-inflammatory effect, can inhibit the production of inflammatory mediators, and relieve inflammation caused by infection or other reasons. Saffron helps resist free radical damage, slows down cell aging, can be anti-inflammatory, regulate the nervous system, improve skin health, slow down skin aging, and minimize damage caused by illness.

[0047] Example 2

[0048] Except for the components, everything else is the same as implementation 1:

[0049] The composition includes the following components: 2 parts of Cnidium monnieri, 2.5 parts of Phellodendron chinense, 3 parts of Dictamni cortex, 0.4 parts of Mentha arvense, 2 parts of Sophora flavescens, 2 parts of Peach kernel, 2 parts of Honeysuckle, 0.2 parts of Salvia miltiorrhiza, 0.2 parts of Carthamus tinctorius, 8 parts of Aloe vera, 6 parts of Rose, 2 parts of Vaccaria segetalis, 3 parts of Leonurus japonicus, 3 parts of Polyhexamethylene biguanide and 10 parts of Relief Preparation

[0050] The relief preparation includes: 2 parts of probiotics, 4 parts of Rhodiola rosea, 3 parts of licorice, and 0.6 parts of saffron.

[0051] Example 3

[0052] Except for the components, everything else is the same as implementation 1:

[0053] 3 parts of Cnidium monnieri, 3 parts of Phellodendron chinense, 5 parts of Dictamni cortex, 0.5 parts of Mentha, 3 parts of Sophora flavescens, 3 parts of Semen persica, 3 parts of Flos lonicerae, 0.3 parts of Salvia miltiorrhiza, 0.3 parts of Carthamus tinctorius, 9 parts of Aloe, 7 parts of Flos Rosae Chinensis, 3 parts of Vaccaria segetalis, 4 parts of Leonurus japonicus, 5 parts of Polyhexamethylene biguanide and 11 parts of relief preparation.

[0054] The relief preparation includes: 3 parts of probiotics, 5 parts of Rhodiola rosea, 4 parts of licorice, and 0.7 parts of saffron.

[0055] A method for preparing a female reproductive tract antibacterial preparation comprises the following steps:

[0056] S1. Extraction of herbs: Cnidium monnieri, Phellodendron amurense and mint were extracted by alcohol extraction, and fresh peel, Sophora flavescens, peach kernel, honeysuckle, Salvia miltiorrhiza, safflower, aloe, rose, Vaccaria segetalis, Leonurus japonicus and polyhexamethylene biguanide were extracted by water extraction, and the extracted herbs were stored for later use;

[0057] S2. Dissolution steps of polyhexamethylene biguanide:

[0058] S21, calculating the amount of polyhexamethylene biguanide;

[0059] S22, select solvent: use deionized water;

[0060] S23, dissolving hexamethylene biguanide: adding the calculated polyhexamethylene biguanide into deionized water, stirring with a stirrer, and setting aside for later use;

[0061] In the above operation:

[0062] During the preparation process, if the final concentration needs to be adjusted, it can be achieved by adding more water or PHMB. For example:

[0063] If you find that the solution is too concentrated, you can dilute it to the desired concentration by adding the appropriate amount of water.

[0064] If the concentration is too low, increase the amount of PHMB and continue stirring until it is completely dissolved.

[0065] Concentration verification

[0066] After preparation, the concentration of PHMB can be verified by the following methods:

[0067] Theoretical calculation: Theoretical calculation is done by weighing and dissolving the amount, which is usually accurate enough.

[0068] Experimental verification: In the experiment, appropriate chemical analysis methods, such as spectrophotometry, can be used to verify the actual concentration of PHMB in the solution.

[0069] Solution storage and stability

[0070] PHMB solution can be stored at room temperature, but in order to ensure its long-term stability, it is best stored in a cool and dry place, away from high temperature or sunlight.

[0071] S3, synthesizing a matrix by adding glycerol, polyvinyl alcohol and carbomer into a blender and stirring to form a gel for later use;

[0072] S4, formula mixing, mixing the materials reserved in steps S1, S2, and S3, adding the mitigation agent, and stirring until there are no bubbles or precipitation;

[0073] S5. Quality control, pH test: ensure the pH value of the product is between 4.5-5.5;

[0074] Microbiological testing: ensuring that the preparation does not contain any harmful microorganisms;

[0075] Antibacterial activity test: confirm the antibacterial effect of the preparation through bacterial inhibition experiments, etc.

[0076] S6. Packaging: Packing the prepared vaginal gel into a sterile container and performing aseptic packaging.

[0077] At the same time, Cnidium monnieri: The main active ingredient is osthole (which has antibacterial and antifungal effects), which can be extracted with alcohol.

[0078] Phellodendron chinense: Mainly contains berberine (which has strong antibacterial effect), which can be extracted with alcohol.

[0079] Dictamni: has strong antibacterial and antifungal effects and is suitable for water extraction.

[0080] Mint: The main ingredient is menthol, which has a cooling effect and can also enhance antibacterial effects and is suitable for alcohol extraction.

[0081] Sophora flavescens: The main ingredient is matrine, which has antibacterial and anti-inflammatory effects and is suitable for water extraction or alcohol extraction.

[0082] Peach kernel: has antibacterial and anti-inflammatory effects and is suitable for water extraction.

[0083] Honeysuckle: Rich in chlorogenic acid and flavonoids, it has antibacterial and antiviral effects and is suitable for water extraction.

[0084] Salvia miltiorrhiza: has antibacterial and anti-inflammatory effects and is suitable for water extraction.

[0085] Safflower: Contains volatile oils and flavonoids, suitable for water extraction.

[0086] Aloe vera: has antibacterial and anti-inflammatory properties and is suitable for water extraction or cold pressing.

[0087] Rose: has a soothing effect and is suitable for water extraction.

[0088] Fenugreek: has antibacterial and anti-inflammatory effects, suitable for water extraction.

[0089] Motherwort: has antibacterial effects and is suitable for water extraction.

[0090] In summary, this product:

[0091] 1. Multiple ingredients

[0092] This combination of herbs and relief preparations can play different therapeutic effects through multiple ingredients, covering the various needs of vaginal diseases. Each combination of medicines has its own unique effect and can be adjusted to different symptoms and causes.

[0093] Heat-clearing and detoxifying, antibacterial and anti-inflammatory: Such as honeysuckle, phellodendron, sophora flavescens, Dictamni, etc., all have strong antibacterial and anti-inflammatory effects, and can effectively fight vaginal infections caused by bacteria, fungi or viruses (such as vaginitis, vulvar itching, etc.).

[0094] Promoting blood circulation and removing blood stasis: Such as peach kernel, salvia miltiorrhiza, safflower, etc., have the effect of promoting blood circulation and removing blood stasis, which helps to improve blood circulation and relieve vaginal discomfort, irregular menstruation and other problems caused by qi stagnation and blood stasis.

[0095] Regulate immunity and inhibit allergic reactions: Probiotics, Rhodiola rosea and other relief preparations can enhance the body's immunity, inhibit inflammatory responses, help maintain the balance of vaginal microecology, and reduce recurrent infections or allergic reactions.

[0096] Reduce swelling, relieve pain, and promote healing: Such as aloe vera, fenugreek, motherwort, etc., have the effect of reducing swelling, relieving pain, and promoting healing, especially in the recovery period after vaginal trauma and surgery, helping to reduce discomfort and accelerate healing.

[0097] 2. Comprehensive treatment effect

[0098] This combination is not limited to treating a single disease, but through the coordination of multiple components, it can comprehensively regulate various vaginal problems. For example, it may solve symptoms such as vaginal inflammation, abnormal secretions, itching, pain, etc. at the same time, instead of relying solely on the efficacy of a single drug.

[0099] 3. Improve the balance of vaginal microecology

[0100] The addition of probiotics is particularly important in this combination. Probiotics can help restore the normal flora in the vagina, inhibit the growth of pathogenic bacteria, and prevent the recurrence of infectious diseases such as vaginitis. The use of probiotics can supplement the insufficient regulation of microecological balance in traditional Chinese medicine treatment.

[0101] 4. Synergistic effects between drugs

[0102] The compatibility of these herbs may form a synergistic effect and enhance the therapeutic effect. For example, Phellodendron chinense and Sophora flavescens both have antibacterial effects, but their mechanisms of action are different. Their combined use may cover a wider range of pathogens and improve the efficacy; at the same time, the blood-activating and blood-stasis-removing effects of safflower and peach kernel can also help improve blood circulation and promote local recovery.

[0103] 5.Higher security

[0104] Compared with Western medicine, many Chinese herbal ingredients may have a lower risk of side effects, especially when used long-term. Combinations of herbal medicines may be suitable for some patients with weaker constitutions, reducing the toxic side effects of drugs and providing a gentler treatment option.

[0105] 6. Supplementary effects of relief preparations

[0106] Relief preparations such as probiotics, rhodiola rosea and licorice can help relieve the discomfort caused by vaginal problems and improve overall health. Probiotics help adjust the microecology of the intestines and vagina, the antioxidant effect of rhodiola rosea helps improve immune function, and licorice has anti-inflammatory and anti-allergic effects.

[0107] Compared with existing treatment methods, the biggest advantage lies in its comprehensive regulation and comprehensive treatment characteristics, especially in enhancing immunity, regulating microecology, and promoting blood circulation and removing blood stasis. It can better adapt to vaginal problems caused by different causes, reduce side effects and improve efficacy.

[0108] The above description is only a preferred embodiment of the present invention and does not limit the present invention in other forms. Any technician familiar with the profession may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes and apply it to other fields. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A female reproductive tract antibacterial preparation, characterized in that: The invention comprises the following components: 1-3 parts of Cnidium monnieri, 2-3 parts of Phellodendron amurense, 1-5 parts of Dictamni cortex, 0.3-0.5 parts of Mentha arvense, 1-3 parts of Sophora flavescens, 1-3 parts of Prunus persica, 1-3 parts of Honeysuckle, 0.1-0.3 parts of Salvia miltiorrhiza, 0.1-0.3 parts of Carthamus tinctorius, 7-9 parts of Aloe vera, 5-7 parts of Rose, 1-3 parts of Vaccaria segetalis, 2-4 parts of Leonurus japonicus, 1-5 parts of Polyhexamethylene biguanide and 9-11 parts of relief preparation.

2. The female reproductive tract antibacterial preparation according to claim 1, characterized in that: The relief preparation comprises: 1-3 parts of probiotics, 3-5 parts of rhodiola rosea, 2-4 parts of liquorice, and 0.5-0.7 parts of saffron; The preparation method of the relief preparation comprises the following steps: (1) Grinding the dried raw materials of liquorice and saffron into coarse powder respectively; (2) Select 70% ethanol as the extraction solvent, put the crude powder of Rhodiola rosea, licorice and saffron into the extractor at a mass ratio of 1:5 to 1:10 to the solvent, and soak for 24 hours; (3) heating the soaked solution to 60-80° C. and performing heating reflux extraction for 1-2 hours. After the extraction solution is heated, use a filter screen or filter cloth to remove the herbal residue to obtain a crude extract; (4) using a rotary evaporator or a reduced pressure evaporation method to concentrate the solvent in the crude extract to a small volume, and the concentrated extract can be further processed by spray drying or freeze drying to obtain a dry powder; (5) Using ethanol to extract the effective component concentrate of Rhodiola rosea, spraying the Rhodiola rosea solution on the surface of the above powder by spray drying, drying, and finally adding probiotics.

3. A method for preparing an antibacterial preparation for the female reproductive tract, characterized in that: The following steps are involved: S1. Herbal extraction; S2, dissolution of polyhexamethylene biguanide; S3, synthetic matrix; S4, formula mixing; S5. Quality control; S6. Packaging.

4. The method for preparing a female reproductive tract antibacterial preparation according to claim 3, characterized in that: In the step S1, the fructus cnidium, cortex phellodendri and mint are extracted by alcohol extraction, and the fresh peel, sophora flavescens, peach kernel, honeysuckle, salvia miltiorrhiza, safflower, aloe, rose, fenugreek, motherwort and polyhexamethylene biguanide are extracted by water extraction, and the extracted products are stored for later use.

5. The method for preparing a female reproductive tract antibacterial preparation according to claim 3, characterized in that: The dissolution of polyhexamethylene biguanide in step S2 comprises the following steps: S21, calculating the amount of polyhexamethylene biguanide; S22, select solvent: use deionized water; S23, dissolving hexamethylene biguanide: adding the calculated polyhexamethylene biguanide into deionized water, stirring with a stirrer, and setting aside for later use.

6. The method for preparing a female reproductive tract antibacterial preparation according to claim 3, characterized in that: In step S3, the matrix is ​​synthesized by adding glycerol, polyvinyl alcohol and carbomer into a stirrer for stirring to form a gel for later use.

7. The method for preparing a female reproductive tract antibacterial preparation according to claim 3, characterized in that: In step S4, the reserved materials in steps S1, S2 and S3 are mixed, and the mitigation agent is added and mixed, and stirred until there are no bubbles or precipitation.

8. The method for preparing a female reproductive tract antibacterial preparation according to claim 3, characterized in that: During the quality control of step S5: Conduct a pH test: Make sure the pH value of the product is between 4.5-5.5; Microbiological testing: ensuring that the preparation does not contain any harmful microorganisms; Antibacterial activity test: The antibacterial effect of the preparation is confirmed through bacterial inhibition experiments, etc.