Traditional Chinese medicine application paste based on meridian point targeted drug delivery and preparation method and application of traditional Chinese medicine application paste

Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine application plaster based on meridian point targeted drug delivery and a preparation method and application thereof.According to the application plaster, by combining traditional Chinese medicine meridian science and a Chinese herbal medicine formula, through the targeted drug delivery principle and combining a meridian point system, drugs are accurately delivered to a focus position through a specific acupoint, and the targeted drug delivery effect is achieved; the medicine effect is fully exerted; the preparation method of the application paste comprises the steps of wall breaking treatment of the traditional Chinese medicine raw materials, addition of the transdermal agent, heating and cooling molding of the paste and the like. The formula of the ointment can be adjusted according to different health problems, and proper herbal medicines and acupuncture points are selected for conditioning according to different diseases; in combination with the sky-stem and earth-branch acupoint selection method, the optimal acupoint is recommended according to the sky-stem and earth-branch combination every day, so that the conditioning effect is more accurate and personalized. Through an external application mode, the side effects of oral medicines are reduced, a convenient, efficient and safe health conditioning scheme is provided, and the traditional Chinese medicine composition is suitable for conditioning various diseases and sub-health problems.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly to a traditional Chinese medicine application paste based on meridian acupoint targeted drug delivery, its preparation method and application. Background Art

[0002] With the changes in modern social lifestyles, more and more people are facing sub - health states and various chronic diseases. Traditional Chinese medicine treatment methods, including acupuncture, massage, herbal medicine treatment, etc., have been widely applied due to their advantages in regulating the body and improving health. However, despite the long - standing traditional Chinese medicine theory, there are still some deficiencies in the clinical application of existing treatment methods.

[0003] Firstly, traditional oral herbal medicine treatment often requires long - term adherence and may cause some discomfort reactions, such as gastrointestinal discomfort and incomplete drug absorption. In addition, long - term oral medication may also burden organs such as the liver and kidneys, especially during the long - term treatment of chronic diseases, these side effects become more obvious. Therefore, the way of delivering drug efficacy through the oral route is not the best choice.

[0004] Secondly, although therapies such as acupuncture and massage can improve the body condition by regulating the meridian system, these therapies often require professional physicians to operate, with low patient compliance and long treatment courses, and are often not suitable for busy modern life. Especially for some common minor pains, fatigue and other problems, patients often need convenient and efficient treatment methods, while traditional therapies may not be able to meet these needs.

[0005] Furthermore, although existing external application pastes can provide certain soothing effects, most of them have a single conditioning function and lack personalized precise treatment. Many existing plasters only simply relieve local pain or reduce swelling, lacking comprehensive and multi - dimensional conditioning, and unable to provide a comprehensive and personalized treatment plan according to the specific symptoms and health problems of patients.

[0006] Therefore, how to provide safe and effective treatment through external plasters, avoid the side - effect problems in traditional treatment methods, and be able to select appropriate drug formulas and acupoints for precise conditioning according to the actual needs of individuals has become an important topic in the development of traditional Chinese medicine treatment technology. Summary of the Invention

[0007] Aiming at the deficiencies of the prior art, the present invention provides a traditional Chinese medicine application paste based on meridian acupoint targeted drug delivery, its preparation method and application, which solve the problems of large side effects, complex treatment process and lack of personalization in existing traditional Chinese herbal medicine treatment methods.

[0008] To achieve the above objectives, the present invention is realized through the following technical solutions: a traditional Chinese medicine plaster for meridian acupoint targeted drug delivery, and the plaster comprises the following traditional Chinese medicine components in percentage by weight: Angelica dahurica 5% - 15%, Radix Paeoniae Rubra 3% - 10%, Semen Sinapis Albae 3% - 8%, Cyathula officinalis Kuan 5% - 10%, Rhizoma Chuanxiong 5% - 10%, Angelica sinensis 4% - 8%, Heracleum hemsleyanum Diels 3% - 7%, Eucommia ulmoides Oliv. 2% - 6%, Astragalus membranaceus (Fisch.) Bunge 5% - 12%, Panax notoginseng 2% - 6%, Ramulus Cinnamomi 3% - 8%, Flos Carthami 3% - 8%, Cortex Cinnamomi 1% - 5%, Rehmannia glutinosa Libosch. 3% - 6%, Moschus 0.1% - 0.5%, and the rest are auxiliary materials and solvents.

[0009] Preferably, the plaster comprises the following traditional Chinese medicine components in percentage by weight: Angelica dahurica 6% - 12%, Radix Paeoniae Rubra 4% - 8%, Semen Sinapis Albae 4% - 7%, Cyathula officinalis Kuan 6% - 9%, Rhizoma Chuanxiong 6% - 9%, Angelica sinensis 5% - 7%, Heracleum hemsleyanum Diels 4% - 6%, Eucommia ulmoides Oliv. 3% - 5%, Astragalus membranaceus (Fisch.) Bunge 6% - 10%, Panax notoginseng 3% - 5%, Ramulus Cinnamomi 4% - 6%, Flos Carthami 4% - 6%, Cortex Cinnamomi 2% - 4%, Rehmannia glutinosa Libosch. 4% - 5%, Moschus 0.2% - 0.4%, and the rest are auxiliary materials and solvents.

[0010] Preferably, the plaster comprises the following traditional Chinese medicine components in percentage by weight: Angelica dahurica 10%, Radix Paeoniae Rubra 6%, Semen Sinapis Albae 5%, Cyathula officinalis Kuan 7%, Rhizoma Chuanxiong 7%, Angelica sinensis 6%, Heracleum hemsleyanum Diels 5%, Eucommia ulmoides Oliv. 4%, Astragalus membranaceus (Fisch.) Bunge 8%, Panax notoginseng 4%, Ramulus Cinnamomi 5%, Flos Carthami 5%, Cortex Cinnamomi 3%, Rehmannia glutinosa Libosch. 5%, Moschus 0.3%, and the rest are auxiliary materials and solvents.

[0011] The present invention also provides a preparation method of the traditional Chinese medicine plaster for meridian acupoint targeted drug delivery, comprising the following steps: a) Carry out wall-breaking treatment on the traditional Chinese medicine raw materials to make the particle size reach more than 800 meshes; b) Mix the wall-broken traditional Chinese medicine raw materials with natural beeswax and rosin, add an appropriate amount of transdermal agent, and stir evenly; c) Heat the mixture to a suitable temperature to make it fully dissolve to obtain a medicinal paste; d) Cool and shape the medicinal paste to obtain the final traditional Chinese medicine plaster.

[0012] Preferably, the wall-breaking treatment step comprises: After cryo-wall-breaking the traditional Chinese medicine raw materials with liquid ammonia, grind them with a jet mill.

[0013] Preferably, the transdermal agent is a composition of menthol, borneol and sinapine, wherein, menthol:borneol:sinapine = 3:1:2.

[0014] Preferably, the addition ratio of the natural beeswax and rosin is: Natural beeswax accounts for 3% - 7% of the total weight of the application plaster; Rosin accounts for 3% - 8% of the total weight of the application plaster.

[0015] The present invention also provides an application method of the traditional Chinese medicine application plaster based on meridian acupoint targeted drug delivery. The Chinese herbal medicine application plaster is adjusted by applying it to specific meridian acupoints. The acupoints are selected according to different health problems, and the health problems include but are not limited to the following: When there is a heart problem, the acupoints are Jiquan, Neiguan, Xinshu, Laogong, Shaofu; When there is a liver problem, the acupoints are Dadun, Taichong, Ganshu, Zhangmen, Zusanli; When there is a spleen problem, the acupoints are Yinbai, Dadu, Pishu, Zusanli; When there is a lung problem, the acupoints are Zhongfu, Yunmen, Tianfu, Feishu, Chize; When there is a kidney problem, the acupoints are Yongquan, Taixi, Shenshu, Fuliu, Zhaohai; When there is a stomach problem, the acupoints are Zhongwan, Shenque, Qihai, Weishu, Daju; When there is a large intestine problem, the acupoints are Shangyang, Hegu, Yangxi, Zhouliao, Tianding; When there is a bladder problem, the acupoints are Jingming, Cuanzhu, Fengmen, Shenshu, Pangguangshu; When there is a triple energizer problem, the acupoints are Waiguan, Zhigou, Tianjing, Jianliao, Yifeng; When there is a sub - health problem, the acupoints are Shenque, Sanyinjiao, Xuehai, Guanyuan; When there is discomfort in the head, shoulders, neck, waist and legs, the acupoints are Dazhui, Jianjing, Fengchi, Xiyangguan.

[0016] Preferably, the application plaster selects acupoints according to the method of taking acupoints according to Heavenly Stems and Earthly Branches, and selects the corresponding acupoints corresponding to the Heavenly Stems and Earthly Branches for conditioning. The method of taking acupoints according to Heavenly Stems and Earthly Branches determines the combination of Heavenly Stems and Earthly Branches according to the date of the day, and selects the corresponding meridian acupoints according to this combination.

[0017] Preferably, the method of taking acupoints according to Heavenly Stems and Earthly Branches includes the following steps: 1) Determine the combination of Heavenly Stems and Earthly Branches according to the current date. The Heavenly Stems and Earthly Branches are associated with specific meridian acupoints through the generating and restraining relationships of the Five Elements; 2) Select the corresponding meridian acupoints according to the combination of Heavenly Stems and Earthly Branches. The acupoints are used to condition the health problems of the patient; 3) Apply the Chinese herbal medicine on the selected acupoints, and transmit the medicinal properties to the lesion site through the meridians to achieve the conditioning effect.

[0018] The present invention provides a traditional Chinese medicine application plaster based on meridian acupoint targeted drug delivery, its preparation method and application. It has the following beneficial effects: 1. The Chinese herbal medicine plaster of the present invention can select corresponding acupoints for application according to different health problems by combining the principles of meridian science and Chinese herbal medicine formulas. Through the method of targeted drug delivery at acupoints, the medicinal effect can be accurately transmitted to the lesion site, enabling the medicinal properties to be directly transported to the target area through relevant meridians, thereby ensuring more effective and precise treatment and avoiding the possible generalization problems of traditional treatment methods.

[0019] 2. By combining the method of selecting acupoints according to the Heavenly Stems and Earthly Branches, the present invention can dynamically select the most suitable acupoints for conditioning according to the date of the day. Through this personalized conditioning plan, each treatment can be matched with the climate and physical condition of the day, which helps to improve the curative effect and the overall health level of the patient, thus maximizing the treatment effect.

[0020] 3. Compared with oral medications, the plaster of the present invention is applied externally. While the drug acts directly on the skin and meridians, it avoids the side effects brought about by gastrointestinal absorption and reduces the burden on the liver and gastrointestinal tract. It is particularly suitable for long-term use and conditioning, being both safe and efficient.

[0021] 4. The Chinese herbal medicine plaster of the present invention is extremely convenient. The patient only needs to apply the plaster on the designated acupoints without complicated operations. The plaster softens at skin temperature and the medicinal properties gradually penetrate, facilitating self-use by the patient at home, greatly improving the operability of the treatment and the compliance of the patient. The use process is simple and efficient.

[0022] 5. The plaster of the present invention combines the pharmacological effects of various Chinese herbal medicines, such as promoting blood circulation to remove blood stasis, relaxing tendons and activating collaterals, reducing swelling and alleviating pain, etc. It can provide comprehensive conditioning for a variety of common diseases and sub-healthy problems. Through precise formula and acupoint selection, the medicinal properties reach the lesion directly through targeted drug delivery at acupoints, which can help relieve pain, improve blood circulation, enhance immunity, etc., and has a significant overall conditioning effect. Detailed implementation mode

[0023] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope of protection of the present invention.

[0024] The present invention provides a traditional Chinese medicine plaster for targeted drug delivery based on meridian acupoints, its preparation method and application. By combining the principles of traditional Chinese medicine meridian theory with modern external herbal plaster technology, the present invention can target drug delivery through specific meridian acupoints, directly transmit the medicinal properties to the lesion site, and precisely regulate various health problems of the body. This technology uses the pathways of the meridian system to ensure that the medicinal effect reaches the required site accurately, ensuring more efficient and precise treatment effects. The following is a detailed description of the embodiments of the present invention.

[0025] The herbal plaster of the present invention contains a variety of classic traditional Chinese medicine ingredients, which are widely used in conditioning and treating various physical discomforts such as rheumatism, arthritis, pain relief, promoting blood circulation to remove blood stasis, etc. The raw materials include but are not limited to the following Chinese herbs: Angelica dahurica, Radix Paeoniae Rubra, Semen Sinapis Albae: These herbs have the effects of expelling wind, promoting blood circulation, and reducing swelling, and can effectively relieve symptoms such as rheumatic joint pain and muscle soreness.

[0026] Cyathula officinalis Kuan, Ligusticum chuanxiong, Angelica sinensis: They have the functions of promoting blood circulation to remove blood stasis and dredging meridians to relieve pain, and are commonly used to treat various pains caused by blood stasis.

[0027] Angelica pubescens, Eucommia ulmoides Oliv., Rhizoma Zedoariae: These herbs have significant effects in relieving bone and joint diseases and are commonly used to treat symptoms such as weakness in the waist and knees and arthritis.

[0028] Astragalus membranaceus, Panax notoginseng, Ramulus Cinnamomi: They have the effects of promoting blood circulation to remove blood stasis and supplementing qi to strengthen the superficial resistance, can promote blood circulation, enhance immunity, and help relieve symptoms caused by poor qi and blood circulation.

[0029] Flos Carthami, Cortex Cinnamomi, Rehmannia glutinosa Libosch.: Such herbs help warm yang and nourish blood, enhance the circulation of qi and blood in the body, and improve symptoms caused by qi and blood deficiency, such as cold pain.

[0030] Moschus, Whitmania pigra Whitman, Eupolyphaga seu Steleophaga: These herbs have strong effects of promoting blood circulation to remove blood stasis and relieving pain, and are widely used in pain relief and detoxification to promote blood circulation.

[0031] In addition, other raw materials such as Flos Caryophylli, Menthol, Borneol, Cistanche deserticola Ma, etc. have the effects of dredging meridians, anti-inflammatory, analgesic, and promoting blood circulation to relax muscles and tendons, and can enhance the overall therapeutic effect of the plaster.

[0032] Based on the medicinal effects of the above-mentioned various Chinese herbs, combined with the extraction process of modern herbs and meridian theory, the herbal plaster of the present invention is scientifically formulated to provide physiotherapy support for different health problems. The specific Chinese medicine ingredients and ratios are as follows: Angelica dahurica 5% - 15%, Radix Paeoniae Rubra 3% - 10%, Semen Sinapis Albae 3% - 8%, Cyathula officinalis Kuan 5% - 10%, Ligusticum wallichii Franch. 5% - 10%, Angelica sinensis (Oliv.) Diels 4% - 8%, Heracleum hemsleyanum Diels 3% - 7%, Eucommia ulmoides Oliv. 2% - 6%, Astragalus membranaceus (Fisch.) Bunge 5% - 12%, Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow 2% - 6%, Cinnamomum cassia Presl 3% - 8%, Carthamus tinctorius L. 3% - 8%, Cinnamomum cassia Presl 1% - 5%, Rehmannia glutinosa (Gaertn.) Libosch. f. hueichingensis (Chao & Kuang) Hsiao & Keng 3% - 6%, Moschus 0.1% - 0.5%, the rest are excipients and solvents.

[0033] Angelica dahurica: Angelica dahurica has the functions of promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, and is commonly used to treat headache, rheumatic pain, joint swelling and pain, etc. The volatile oil components it contains can effectively relieve pain and reduce inflammation, and are applicable to various meridian problems.

[0034] Radix Paeoniae Rubra: Radix Paeoniae Rubra has the effects of promoting blood circulation to remove blood stasis, reducing swelling and relieving pain. It is commonly used to improve pain problems caused by blood stasis, especially for lower limb pain, arthritis and other symptoms. Its pharmacological effects help promote blood circulation and enhance immunity.

[0035] Semen Sinapis Albae: Semen Sinapis Albae has the functions of dispelling wind and dampness, promoting blood circulation and dredging collaterals. Its main component, isothiocyanate, has anti - inflammatory and analgesic effects, and can effectively dredge the meridians, relieve joint pain and muscle soreness.

[0036] Cyathula officinalis Kuan: Cyathula officinalis Kuan is used for strengthening tendons and bones, dispelling wind - dampness, and promoting blood circulation and dredging collaterals. It is commonly used to treat joint pain caused by rheumatism, and has obvious analgesic and anti - inflammatory effects, and can promote joint fluid circulation.

[0037] Ligusticum wallichii Franch.: Ligusticum wallichii Franch. is widely used for promoting blood circulation to remove blood stasis, dredging channels and relieving pain, especially effective in treating pain and inflammation caused by poor blood circulation. Its main components have a regulatory effect on the blood system and help relieve various diseases caused by blood stasis.

[0038] Angelica sinensis (Oliv.) Diels: Angelica sinensis (Oliv.) Diels is a common blood - nourishing Chinese medicinal material, with the functions of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain. Its pharmacological effects are of great significance for promoting blood circulation and improving meridian health, and are commonly used to treat blood deficiency and various symptoms caused by it.

[0039] Heracleum hemsleyanum Diels: Heracleum hemsleyanum Diels has the effects of dispelling wind - dampness, dredging collaterals and relieving pain, and is commonly used to treat rheumatoid arthritis, muscle pain and other symptoms. Its effect on dredging the meridians and relieving pain is particularly prominent, and it is an effective ingredient for relieving pain, reducing swelling and relieving pain.

[0040] Eucommia ulmoides Oliv.: Eucommia ulmoides Oliv. has the functions of strengthening tendons and bones, tonifying the liver and kidney, and is commonly used to treat weakness in the waist and knees, fractures, etc. Its pharmacological effects relieve pain by improving bone and muscle health, and have a good conditioning effect on rheumatoid arthritis and osteoporosis.

[0041] Astragalus membranaceus: Astragalus membranaceus is a classic qi-tonifying herb in traditional Chinese medicine, with the effects of tonifying qi and ascending yang, securing the exterior and stopping sweating, benefiting the spleen and strengthening the spleen. Its regulatory effect on the immune system enables it to enhance the body's resistance, promote blood circulation, and contribute to the excretion of toxins and metabolism in the body.

[0042] Panax notoginseng: Panax notoginseng has the effects of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, and is commonly used to treat sequelae of trauma, blood stasis diseases, etc. The main components of Panax notoginseng can improve blood flow, relieve blood vessel blockage, and thus promote the health of various organs in the body.

[0043] Cinnamomum cassia: Cinnamomum cassia has the effects of warming yang and relieving exterior syndrome, promoting blood circulation and dredging collaterals. It is commonly used for symptoms such as rheumatic pain, headache, joint stiffness caused by exogenous wind-cold. Its volatile oil components have analgesic and anti-inflammatory effects, helping to smooth qi and blood.

[0044] Carthamus tinctorius: Carthamus tinctorius has the effects of promoting blood circulation to remove blood stasis, promoting qi movement and relieving pain. It is commonly used to improve the blockage of meridians and relieve pain caused by qi and blood stasis, such as arthritis, dysmenorrhea and other diseases.

[0045] Cinnamomum cassia: Cinnamomum cassia has the effects of warming yang and dispelling cold, promoting blood circulation and qi movement, and can effectively relieve joint pain and coldness of the limbs caused by cold-dampness. Its pharmacological effects can improve meridian blockage and enhance the body's heat through the method of warming yang.

[0046] Rehmannia glutinosa: Rehmannia glutinosa has the effects of nourishing yin and tonifying blood, nourishing the liver and kidneys, and is suitable for various discomforts caused by blood deficiency, especially remarkable in regulating menstrual disorders and relieving muscle soreness.

[0047] Moschus: Moschus has the effects of promoting blood circulation to remove blood stasis, dredging meridians and relieving pain, and can quickly relieve severe pain, promote blood circulation and qi movement. It is commonly used to treat pain after acute trauma and has a significant analgesic effect.

[0048] Excipients and solvents: In addition to the above main medicinal materials, appropriate amounts of beeswax, rosin and other excipients are added to the plaster. These components are mainly used to adjust the texture and adhesiveness of the plaster, so that it can firmly adhere to the skin during use and ensure the stable release of the drug effect. The addition of transdermal agents can enhance the permeability of the drug and ensure that the drug effect can effectively penetrate the skin and reach the required lesion site.

[0049] The ratios of these traditional Chinese medicine components in the plaster of the present invention are verified through multiple clinical investigations and experiments to ensure that each component can exert the best effect under their interaction. Through reasonable ratios, it can target different health problems, promote smooth qi and blood, dredge tendons and activate collaterals, reduce swelling and relieve pain, and regulate the body functions.

[0050] Accordingly, the present invention also provides a method for preparing a Chinese medicine plaster based on meridian acupoint targeted drug delivery, which ensures that the active ingredients of the plaster can penetrate the skin through the meridian acupoints and exert a conditioning effect. The following is a detailed preparation process of the present invention: Step a) wall breaking treatment of Chinese medicine raw materials: First, the selected Chinese medicine raw materials are broken to improve the release and absorption rate of the drug ingredients. The wall breaking process is to destroy the cell wall of the medicinal material by physical means to ensure that the active ingredients can be fully released and utilized.

[0051] The preferred method of breaking the wall is: Liquid ammonia freezing breaking the wall. This step uses liquid ammonia freezing to form micro cracks on the surface of the Chinese medicine raw materials, thereby increasing the surface area of ​​the medicine.

[0052] Subsequently, the frozen Chinese medicine raw materials are ground using a jet mill to ensure that the particle size reaches above 800 meshes, thus ensuring the full release of the medicinal ingredients.

[0053] Step b) Mixing Chinese medicinal materials with auxiliary materials: After the wall of the Chinese medicine is broken, an appropriate amount of auxiliary materials are added to help the formation of the ointment and enhance the drug's transdermal ability.

[0054] Natural beeswax and rosin are the main ingredients of the ointment. Their function is to increase the adhesion and stability of the ointment. During use, they can soften at skin temperature to help drug penetration.

[0055] Natural beeswax accounts for 3% to 7% of the total weight of the patch.

[0056] Rosin accounts for 3% to 8% of the total weight of the plaster.

[0057] Mix the broken Chinese medicinal materials with natural beeswax and rosin in proportion to ensure their even distribution.

[0058] At the same time, in order to enhance the permeability of the drug, an appropriate amount of transdermal agent is added. A combination of menthol, borneol and sinapinic acid is selected and mixed according to the proportion. The role of the transdermal agent is to promote the rapid absorption of the drug ingredients through the skin and directly act on the meridians and acupoints. The proportion of the transdermal agent is: Menthol: borneol: sinapinic acid = 3:1:2, this ratio helps to enhance the penetration of the drug and the stability of the drug.

[0059] Step c) heating the mixture to a suitable temperature: The drug and excipients mixed evenly in step b) are placed in a reaction container and heated. The heating temperature needs to be controlled between 50-70° C. to ensure that the beeswax and rosin can be dissolved without destroying the effectiveness of the drug components.

[0060] During this process, the mixture of the drug and excipients is continuously heated and stirred to ensure that all components are fully dissolved, resulting in a homogeneous ointment.

[0061] Step d) Cooling and shaping: After the mixture is fully dissolved in step c), it is cooled to room temperature to gradually solidify and form the desired ointment. During this process, the texture of the ointment will gradually become viscous, forming a paste that can be stably used.

[0062] According to actual needs, a mold can be used to shape the ointment into sheets or strips for easy use and storage.

[0063] Through the above steps, the finally obtained Chinese herbal medicine plaster can not only ensure the persistence of the medicinal effect, but also ensure good adhesion and permeability during use, and can reach the acupoints through the skin for conditioning.

[0064] The Chinese herbal medicine plaster of the present invention is applied to specific meridian acupoints, and uses the principle of targeted drug delivery through meridian acupoints to provide precise conditioning effects for different health problems. By selecting acupoints and ointment formulas that match the health problems, the medicinal properties can accurately reach the lesion site, ensuring the maximization of the medicinal effect and achieving a more efficient and precise treatment effect. The following are the specific embodiments of the application method of the Chinese herbal medicine plaster of the present invention.

[0065] Step 1: Select appropriate health problems and acupoints Heart problems: For heart-related problems such as heart diseases and palpitations, the selected acupoints are Jiquan, Neiguan, Xinshu, Laogong, Shaofu, etc. The Chinese herbal medicine plaster will be applied to these specific acupoints, and through meridians such as the Heart Meridian of Hand-Shaoyin and the Pericardium Meridian of Hand-Jueyin, the medicinal effect can directly reach the heart area and play a physical therapy role.

[0066] Liver problems: Liver problems include liver insufficiency and stagnation of liver qi. The recommended conditioning acupoints are Dadun, Taichong, Ganshu, Zusanli, etc. Through the conduction of the Liver Meridian of Foot-Jueyin, the drug can effectively act on the liver.

[0067] Spleen problems: Common spleen problems such as spleen deficiency and indigestion, and the related acupoints are Pishu, Sanyinjiao, Zusanli, etc. The ointment regulates the function of the spleen through the meridian action of the Spleen Meridian of Foot-Taiyin, promoting digestion and absorption.

[0068] Lung problems: For lung health problems such as cough and shortness of breath, the recommended conditioning acupoints are Feishu, Zhongfu, Yunmen, Tianfu, etc. Through the conduction of the Lung Meridian of Hand-Taiyin, the drug can directly regulate the lungs and promote the recovery of respiratory function.

[0069] Kidney problems: For kidney health problems such as kidney deficiency, soreness and weakness in the waist and knees, etc., the acupoints used include Shenshu, Yongquan, Taixi, Zhaohai, etc. Through the action of the Foot-Shaoyin Kidney Meridian, the kidney function is regulated to help restore physical strength and anti-fatigue.

[0070] Stomach problems: For stomach-related diseases such as gastritis and indigestion, the recommended acupoints are Zhongwan, Shenque, Qihai, Weishu, etc. Through the conduction of the Foot-Yangming Stomach Meridian, the ointment can effectively regulate the stomach and improve the digestive function.

[0071] Large intestine problems: For large intestine health problems such as constipation and diarrhea, the commonly used acupoints are Shangyang, Hegu, Yangxi, Dachangshu, etc. The medicinal properties of the ointment act on the large intestine through the Hand-Yangming Large Intestine Meridian to achieve the physical therapy effect.

[0072] Bladder problems: For bladder health problems such as frequent urination and urgency, the related regulating acupoints are Pangguangshu, Zhonglushu, Weizhong, etc. Through the transmission of the Foot-Taiyang Bladder Meridian, the medicinal efficacy can effectively act on the bladder and relieve related symptoms.

[0073] Triple energizer problems: Triple energizer problems involve the body's fluid regulation. The regulating acupoints include Waiguan, Zhigou, Tianjing, etc. The medicinal efficacy of the ointment is conducted through the Hand-Shaoyang Triple Energizer Meridian to improve the body's overall fluid metabolism.

[0074] Sub-health problems: Sub-health status can be regulated through acupoints such as Shenque, Sanyinjiao, Xuehai, Guanyuan. Through the relevant acupoints of the twelve meridians, it reaches various systems in the body, restores the body's functions, and enhances physical strength and immunity.

[0075] Discomfort in the head, shoulders, neck, waist and legs: For common shoulder soreness, low back pain, and leg discomfort, the recommended acupoints include Dazhui, Jianjing, Xiyangguan, etc. The ointment transmits the medicinal efficacy through the meridians to relieve pain and stiffness.

[0076] Thyroid problems: For thyroid health problems such as abnormal thyroid function, the recommended acupoint is Guanyuan. The medicinal properties of traditional Chinese medicine are conducted through the twelve meridians to help regulate the thyroid function.

[0077] Prostate problems: For prostate health problems such as prostatitis and hyperplasia, the commonly used acupoints are Zhongliao, Sanyinjiao, Guanyuan. The ointment regulates the prostate through the relevant meridian acupoints.

[0078] Ovarian problems: For ovarian health problems such as ovarian cysts and irregular menstruation, the recommended acupoints include Guanyuan, Sanyinjiao, and Xuehai. By regulating the ovarian function through relevant acupoints, the physiological cycle can be improved.

[0079] Breast problems: For problems such as mastitis and breast hyperplasia, the commonly used acupoints are Guanyuan, the reflex area of the breast, and the back breast reflex area, etc. Through these specific acupoints, the medicinal plaster can effectively improve breast health.

[0080] Yang strengthening problems: For the regulation of physical weakness and insufficient yang qi, the commonly used acupoints include Mingmen, Guanyuan, Xuehai, etc. By regulating through these acupoints, it helps to restore the yang qi in the body and enhance physical strength.

[0081] Step 2: Acupoint selection method based on Heavenly Stems and Earthly Branches Preferably, the application method of the present invention also combines the acupoint selection method based on Heavenly Stems and Earthly Branches. This method determines the combination of Heavenly Stems and Earthly Branches according to the date of the day, and then selects the corresponding meridian acupoints for regulation.

[0082] Specific implementation steps of the acupoint selection method based on Heavenly Stems and Earthly Branches: Determine the combination of Heavenly Stems and Earthly Branches: According to the current date, calculate the combination of Heavenly Stems and Earthly Branches through the pairing rules of Heavenly Stems and Earthly Branches. For example, if today is Gengxu day, then select the relevant combination of Heavenly Stems and Earthly Branches according to the pairing result of Heavenly Stems and Earthly Branches.

[0083] Select relevant acupoints: According to the combination of Heavenly Stems and Earthly Branches, combined with the Five Elements theory and the relationship of generation and restriction, select the corresponding meridian acupoints. Different combinations of Heavenly Stems and Earthly Branches correspond to different meridians and acupoints. Through these meridians, the medicinal effect is transmitted to achieve a more precise regulation effect.

[0084] Apply the plaster for treatment: Apply the Chinese herbal plaster of the present invention on the selected acupoints. Through the action of the meridians, the medicinal effect can directly reach various systems and lesion sites of the body, thereby exerting the best treatment effect.

[0085] As an example, on February 10, 2025 (Gengxu day), the corresponding acupoints are (refer to the following table):

[0086] If the patient needs to regulate stomach problems, the stomach-related acupoints are (refer to the following table):

[0087] Through these regulation methods, the plaster of the present invention can achieve personalized regulation through precise acupoint selection and the acupoint selection method based on Heavenly Stems and Earthly Branches, and achieve a fast and effective physical therapy effect.

[0088] The present invention further combines intelligent technologies and proposes an application method for traditional Chinese medicine syndrome differentiation and acupoint selection through an intelligent APP. This method can, based on information such as the user's health status, symptoms, and constitution, intelligently recommend the most suitable traditional Chinese herbal plaster formula and corresponding meridian acupoints, thereby achieving personalized physiotherapy and conditioning.

[0089] Step 1: The user inputs health information Health data entry: The user inputs personal health status information through the intelligent APP, including but not limited to: Symptom description: Such as heart problems, liver problems, disharmony of the spleen and stomach, joint pain, sub-healthy state, etc.

[0090] Constitution information: Such as whether it is cold or hot, and whether there is an allergy history, etc.

[0091] Age, gender, living habits: These data help to judge the user's physical condition and, combined with modern traditional Chinese medicine syndrome differentiation theory, determine the conditioning direction.

[0092] Other additional symptoms: Such as sleep quality, stress, mood swings, etc.

[0093] Intelligent diagnosis and analysis: Based on the input health information, the intelligent APP uses traditional Chinese medicine syndrome differentiation theory (such as yin-yang, five elements, qi and blood, etc.) combined with symptoms for preliminary diagnosis. The APP will analyze the user's symptoms through algorithms, identify possible health problems of the user, and deduce the most suitable conditioning method through traditional Chinese medicine theory.

[0094] Step 2: Intelligently recommend traditional Chinese herbal formula and acupoints Recommend herbal formula: According to the analysis results, the APP will automatically recommend a traditional Chinese herbal formula suitable for the user, including specific herbal ingredients and their proportions. For example, if the user's symptoms involve disharmony of the spleen and stomach, the APP may recommend a formula containing herbs such as Astragalus membranaceus, Angelica sinensis, and Cornus officinalis; if it is a joint pain problem, it may recommend ingredients such as Chuanxiong rhizome, Eucommia ulmoides, and Angelica pubescens.

[0095] Intelligent matching of acupoints: According to the user's symptoms and health problems, the APP will intelligently recommend meridian acupoints related to the problem. The system will select relevant main and auxiliary acupoints based on traditional Chinese medicine meridian theory. For example: Heart problems: Recommend acupoints such as Jiquan, Neiguan, and Xinshu.

[0096] Liver problems: Recommend acupoints such as Dadun, Taichong, and Ganshu.

[0097] Sub-healthy problems: Recommend acupoints such as Shenque, Sanyinjiao, and Xuehai.

[0098] Meanwhile, the APP can also recommend additional conditioning acupoints for users according to the method of selecting acupoints based on the Heavenly Stems and Earthly Branches, ensuring the maximization of the daily conditioning effect.

[0099] Step 3: Dynamically update acupoint recommendations according to the method of the Heavenly Stems and Earthly Branches Combination of the Heavenly Stems and Earthly Branches: Every day, the APP automatically calculates the combination of the Heavenly Stems and Earthly Branches of the current day according to the date, and intelligently updates the recommended acupoints based on the relationship of the generation and restriction of the Five Elements. For example, if today is Gengxu Day, the system will select the best conditioning acupoints related to this day based on the relationship between the Five Elements and the meridians.

[0100] Combined with the Heavenly Stems and Earthly Branches: The APP recommends specific Chinese herbal plaster and acupoints for users to condition according to the Heavenly Stems and Earthly Branches of the current day. The specific steps include: Recommend the corresponding acupoints according to the Five-Element attributes of the Heavenly Stems and Earthly Branches.

[0101] Update the daily herbal formula to make it more in line with the climate, physical condition and corresponding changes of the Heavenly Stems and Earthly Branches of the current day.

[0102] Step 4: Personalized conditioning suggestions and reminders Real-time feedback and adjustment: After the user uses the plaster through the APP, they can give real-time feedback on the usage experience, such as the efficacy of the medicine, skin reactions, etc. The APP intelligently adjusts the subsequent plaster formula and acupoint recommendations according to the feedback information of the user to ensure the continuous optimization of the conditioning effect.

[0103] Health tracking and reminder: The APP provides a health tracking function, regularly evaluates the user's health status and provides conditioning suggestions. For example, regularly measuring and recording blood pressure, pulse, weight, sleep quality, etc., the APP will adjust the plaster formula and recommended acupoints according to the health index data to help the user continuously maintain a healthy state.

[0104] Step 5: User education and guidance Popularization of traditional Chinese medicine knowledge: In addition to intelligent diagnosis and treatment, the APP also provides users with rich traditional Chinese medicine knowledge, such as meridian theory, acupoint functions, herbal medicine knowledge, etc., to help users understand the conditioning process. It guides users on how to correctly use the Chinese herbal plaster and how to accurately press or stimulate the designated acupoints in the form of pictures, texts and videos.

[0105] Record and analysis of the treatment process: After using the APP, users can record each application process and effect. The APP will analyze the progress of the treatment and provide personalized suggestions to help users gradually improve their health status.

[0106] With the support of the intelligent APP, the traditional Chinese medicine syndrome differentiation and acupoint conditioning method of the present invention can provide personalized health management services for users. The APP collects users' health data, conducts intelligent diagnosis and analysis, combines traditional Chinese medicine syndrome differentiation and the theory of heavenly stems and earthly branches, and automatically recommends appropriate traditional Chinese medicine formulas and corresponding acupoints to help users obtain accurate, continuous, and effective physiotherapy effects when conditioning health problems.

[0107] To better understand the present invention, the above method will be described in detail below with reference to specific embodiments.

[0108] Example 1: Traditional Chinese medicine plaster for heart problems Formulation composition: Angelica dahurica: 10% Chuanxiong rhizome: 8% Angelica sinensis: 6% Safflower: 5% Notoginseng: 4% Ramulus cinnamomi: 6% Rehmannia glutinosa: 5% Moschus: 0.3% Natural beeswax: 5% Colophony: 6% Menthol: 2% Transdermal agent (composition of menthol, borneol, and sinapine): menthol: borneol: sinapine = 3:1:2.

[0109] Preparation method: Wall-breaking treatment: After freezing the traditional Chinese medicine raw materials with liquid ammonia for wall-breaking, use an air-flow pulverizer to grind them to ensure that the particle size reaches over 800 meshes.

[0110] Mixing and heating: Mix the wall-broken traditional Chinese medicine powder with natural beeswax and colophony, add an appropriate amount of transdermal agent, stir evenly, and heat to 60 °C to completely dissolve and obtain the plaster.

[0111] Cooling and forming: Cool the plaster to room temperature and form it into a paste for convenient use.

[0112] Application method: Select corresponding acupoints according to heart problems, such as Jiquan, Neiguan, Xinshu, Laogong, Shaofu, etc., and apply the plaster to these acupoints.

[0113] The plaster reaches the heart directly through the Heart Meridian of Hand-Shaoyin, the Pericardium Meridian of Hand-Jueyin and other specific Ashi points to help condition heart health.

[0114] By applying the patch once a day, the medicinal effect can help relieve heart-related symptoms such as chest tightness and palpitations.

[0115] Example 2: Chinese herbal medicine plaster for liver problems Formulation composition: Cyathula officinalis: 10% Astragalus membranaceus: 8% Panax notoginseng: 5% Angelica pubescens: 7% Ganshu (BL18): 6% Eucommia ulmoides: 6% Aconitum kusnezoffii: 3% Hirudo: 0.5% Natural beeswax: 4% Colophony: 5% Menthol: 2% Transdermal agent (composition of menthol, borneol, and sinapine): menthol:borneol:sinapine = 3:1:2.

[0116] Preparation method: Cell wall breaking treatment: Freeze the Chinese herbal medicine raw materials with liquid ammonia and then grind them with an air flow pulverizer to ensure that the particle size reaches over 800 meshes.

[0117] Mixing and heating: Mix the cell wall broken Chinese herbal medicine raw materials with natural beeswax and colophony, add an appropriate amount of transdermal agent, stir evenly and then heat to 65°C to ensure that the plaster is fully dissolved.

[0118] Cooling and forming: Cool the plaster to room temperature and form it into a paste for easy application.

[0119] Application method: For liver problems, select acupoints such as Dadun (LR1), Taichong (LR3), Ganshu (BL18), and Zusanli (ST36).

[0120] Apply the plaster to these specific acupoints to directly regulate the liver function through the Jueyin Liver Meridian of Foot and other specific Ashi points.

[0121] By continuously applying the plaster for 3 - 5 days, it can help relieve symptoms caused by stagnation of liver qi, such as hypochondriac pain and indigestion.

[0122] Example 3: Chinese herbal medicine plaster for bladder problems Formulation composition: Ramulus Cinnamomi: 8% Flos Carthami: 6% Panax notoginseng: 4% Rhizoma Chuanxiong: 5% Strychnos nux-vomica: 3% Rehmannia glutinosa: 5% Cinnamomum cassia: 3% Pheretima: 2% Natural beeswax: 5% Colophony: 6% Menthol: 1% Transdermal agent (menthol, borneol, sinapine composition): menthol:borneol:sinapine = 3:1:2.

[0123] Preparation method: Wall-breaking treatment: The traditional Chinese medicine raw materials are treated by liquid ammonia freezing wall-breaking method and ground to more than 800 meshes by an air-flow pulverizer.

[0124] Mixing and heating: Mix the traditional Chinese medicine powder with transdermal agents such as beeswax, colophony, and menthol, stir evenly, and then heat to 50 - 65 °C to ensure complete dissolution of the ointment.

[0125] Cooling and forming: The ointment is cooled and formed into a paste for topical application.

[0126] Application method: For bladder problems such as frequent urination and urgency, the recommended acupoints include Bladder Shu (BL23), Zhonglü Shu (BL29), Weizhong (BL40), etc.

[0127] Apply the ointment to these specific acupoints, and the medicinal effect is transmitted to the bladder through the Bladder Meridian of Foot-Taiyang to regulate bladder health.

[0128] Continuously use the ointment, apply it 1 - 2 times a day, and the effect is significant, which can relieve related symptoms.

[0129] Example 4: Chinese herbal medicine topical application paste for sub-health problems Formulation composition: Astragalus membranaceus: 12% Codonopsis pilosula: 8% Lycium barbarum: 5% Angelica sinensis: 6% Rehmannia glutinosa: 4% Paeonia lactiflora: 5% Glycyrrhiza uralensis: 4% Natural beeswax: 5% Colophony: 6% Menthol: 2% Transdermal agent (menthol, borneol, sinapine composition): menthol:borneol:sinapine = 3:1:2.

[0130] Preparation method: Wall-breaking treatment: The traditional Chinese medicine raw materials are subjected to liquid ammonia freezing wall-breaking, and then the medicinal materials are pulverized to more than 800 meshes by an air-flow pulverizer.

[0131] Mixing and heating: Mix the wall-broken traditional Chinese medicine with transdermal agents such as beeswax, colophony, and menthol, stir evenly, and heat to 60 °C to ensure complete dissolution of the ointment.

[0132] Cooling and forming: The ointment is cooled to room temperature to form a paste suitable for use.

[0133] Application method: For sub-healthy problems, the recommended acupoints include Shenque, Sanyinjiao, Xuehai, Guanyuan, etc.

[0134] Apply the Chinese herbal ointment to these acupoints. Through the action of the twelve meridians, regulate the qi and blood of the whole body to help restore the normal functions of the body.

[0135] Use continuously for 5 - 7 days to help relieve fatigue, improve sleep and enhance immunity.

[0136] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine plaster based on meridian acupoint targeted drug delivery, characterized in that: The patch comprises the following Chinese medicinal ingredients in percentage by weight: Angelica dahurica 5%~15%, red peony root 3%~10%, white mustard seed 3%~8%, Sichuan cyathula 5%~10%, Chuanxiong 5%~10%, whole angelica 4%~8%, Duhuo 3%~7%, Eucommia 2%~6%, Astragalus 5%~12%, Panax notoginseng 2%~6%, cassia twig 3%~8%, safflower 3%~8%, cinnamon bark 1%~5%, rehmannia glutinosa 3%~6%, musk 0.1%~0.5%, and the rest are auxiliary materials and solvents.

2. The Chinese medicine plaster based on meridian acupoint targeted drug delivery according to claim 1, characterized in that: The patch comprises the following Chinese medicinal ingredients in percentage by weight: Angelica dahurica 6%~12%, red peony root 4%~8%, white mustard seed 4%~7%, Sichuan cyathula 6%~9%, Chuanxiong 6%~9%, whole angelica 5%~7%, Duhuo 4%~6%, Eucommia 3%~5%, Astragalus 6%~10%, Panax notoginseng 3%~5%, cinnamon twig 4%~6%, safflower 4%~6%, cinnamon bark 2%~4%, rehmannia glutinosa 4%~5%, musk 0.2%~0.4%, and the rest are auxiliary materials and solvents.

3. The Chinese medicine plaster based on meridian acupoint targeted drug delivery according to claim 1, characterized in that: The patch comprises the following Chinese medicinal ingredients in percentage by weight: Angelica dahurica 10%, red peony root 6%, white mustard seed 5%, Sichuan cyathula 7%, Chuanxiong 7%, whole angelica 6%, Duhuo 5%, Eucommia 4%, Astragalus 8%, Panax notoginseng 4%, cinnamon twig 5%, safflower 5%, cinnamon bark 3%, rehmannia glutinosa 5%, musk 0.3%, and the rest are auxiliary materials and solvents.

4. A method for preparing a Chinese medicine plaster based on meridian and acupoint targeted drug delivery, which is used to prepare a Chinese medicine plaster based on meridian and acupoint targeted drug delivery as claimed in any one of claims 1 to 3, characterized in that: The following steps are involved: a) breaking the wall of the Chinese medicine raw materials to make the particle size reach above 800 mesh; b) mixing the wall-broken Chinese medicinal raw materials with natural beeswax and rosin, adding an appropriate amount of transdermal agent, and stirring evenly; c) heating the mixture to a suitable temperature to fully dissolve it to obtain an ointment; d) cooling and shaping the ointment to obtain the final Chinese herbal medicine ointment.

5. The method for preparing the Chinese medicine plaster based on meridian acupoint targeted drug delivery according to claim 4, characterized in that: The cell wall breaking step comprises: The raw materials of traditional Chinese medicine are frozen and broken by liquid ammonia, and then ground by air flow mill.

6. The method for preparing the Chinese medicine plaster based on meridian acupoint targeted drug delivery according to claim 4, characterized in that: The transdermal agent is a composition of menthol, borneol and sinapinic acid, wherein the ratio of menthol: borneol: sinapinic acid is 3:1:

2.

7. The method for preparing the Chinese medicine plaster based on meridian acupoint targeted drug delivery according to claim 4, characterized in that: The addition ratio of the natural beeswax and rosin is: Natural beeswax accounts for 3% to 7% of the total weight of the patch; Rosin accounts for 3% to 8% of the total weight of the plaster.

8. An application method of a Chinese medicine plaster based on meridian and acupoint targeted drug delivery, based on the Chinese medicine plaster based on meridian and acupoint targeted drug delivery as claimed in any one of claims 1 to 3, characterized in that: The Chinese herbal medicine plaster is applied to specific meridian acupoints for conditioning, and the acupoints are selected according to different health problems, including but not limited to the following: In case of heart problems, the acupoints are Jiquan, Neiguan, Xinshu, Laogong, Shaofu; In case of liver problems, the acupoints are Dadun, Taichong, Ganshu, Zhangmen, and Zusanli; When it comes to spleen problems, the acupoints are Yinbai, Dadu, Pishu, and Zusanli; When it comes to lung problems, the acupoints are Zhongfu, Yunmen, Tianfu, Feishu, and Chize; In case of kidney problems, the acupoints are Yongquan, Taixi, Shenshu, Fuliu and Zhaohai; When it comes to stomach problems, the acupoints are Zhongwan, Shenque, Qihai, Weishu, and Daju; When it comes to large intestine problems, the acupoints are Shangyang, Hegu, Yangxi, Elbow, and Tianding; When it comes to bladder problems, the acupoints are Jingming, Zanzhu, Fengmen, Shenshu, and Bladdershu; When it comes to triple energizer problems, the acupoints are Waiguan, Zhigou, Tianjing, Jianliao, and Yifeng; In case of sub-health problems, the acupoints are Shenque, Sanyinjiao, Xuehai, and Guanyuan; When there is discomfort in the head, shoulders, neck, waist and legs, the acupoints are Dazhui, Jianjing, Fengchi and Xiyangguan.

9. The application method of the Chinese medicine plaster based on meridian acupoint targeted drug delivery according to claim 8, characterized in that: The plaster selects acupoints according to the Heavenly Stems and Earthly Branches acupoint selection method, and selects acupoints corresponding to the Heavenly Stems and Earthly Branches for conditioning. The Heavenly Stems and Earthly Branches acupoint selection method determines the combination of the Heavenly Stems and Earthly Branches according to the date of the day, and selects the meridian acupoints corresponding to the combination according to the combination.

10. The application method of the Chinese medicine plaster based on meridian acupoint targeted drug delivery according to claim 9, characterized in that: The method for selecting acupuncture points according to the Heavenly Stems and Earthly Branches comprises the following steps: 1) determining a combination of heavenly stems and earthly branches according to the current date, wherein the heavenly stems and earthly branches are associated with specific meridian acupuncture points through the mutual generation and mutual restraint relationship of the five elements; 2) selecting corresponding meridian acupuncture points according to the combination of heavenly stems and earthly branches, wherein the acupuncture points are used to treat the health problems of the patient; 3) Apply Chinese herbal medicine to the selected acupuncture points to transfer the medicinal properties to the lesion site through the meridians to achieve a conditioning effect.

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