Traditional Chinese medicine composition for drying dampness, reducing phlegm, regulating qi and relieving cough as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for eliminating dampness and phlegm and regulating qi to arrest cough as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 140 to 190 parts of fructus perillae, 140 to 190 parts of semen sinapis, 140 to 190 parts of semen raphani, 80 to 120 parts of rhizoma arisaematis, 140 to 190 parts of cortex magnoliae officinalis, 140 to 190 parts of radix peucedani, 170 to 230 parts of pericarpium citri reticulatae, 140 to 190 parts of pummelo peel, 220 to 280 parts of poria cocos, 220 to 280 parts of radix platycodonis and 80 to 120 parts of liquorice root. The traditional Chinese medicine composition has a good curative effect on symptoms such as cough, excessive phlegm, chest distress, wheeze, heavy body and tiredness, and can effectively solve the problems of existing medicines.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough, and a preparation method and application thereof. Background Art

[0002] Chronic bronchitis is a chronic nonspecific inflammation of the trachea, bronchial mucosa and surrounding tissues, with cough and sputum as the main clinical symptoms, or wheezing, which lasts for 3 months or more each year for 2 years or more, and other diseases with symptoms of cough, sputum and wheezing are excluded.

[0003] Emphysema is a pathological state in which the airway elasticity at the distal end of the terminal bronchioles is reduced, over-expanded, inflated, and the lung volume is increased, or accompanied by airway wall destruction, and the main manifestations are dyspnea, cough, sputum, wheezing, and chest tightness.

[0004] Cor pulmonale is a heart disease of lung origin, which is caused by lesions in the broncho-pulmonary tissue, thorax or pulmonary vessels, leading to increased pulmonary vascular resistance, pulmonary hypertension, and subsequent changes in the structure and / or function of the right ventricle. The main symptoms are cough, sputum, and dyspnea.

[0005] Asthma is a chronic inflammatory disease of the airways involving a variety of cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, airway epithelial cells, etc.) and cell components. This chronic inflammation is associated with airway hyperresponsiveness, and usually presents with widespread and variable reversible expiratory airflow limitation, leading to recurrent symptoms such as wheezing, shortness of breath, chest tightness, and / or coughing, which often occur and worsen at night and / or in the early morning. Most patients can be relieved on their own or through treatment.

[0006] The above diseases are mostly manifested as cough, sputum, chest tightness, wheezing, etc. At present, although there are corresponding treatment methods for the above diseases, most of the existing chemotherapeutic drugs have serious side effects and strong dependence, while most of the existing Chinese patent medicines have limited therapeutic effects. Summary of the invention

[0007] In view of the above-mentioned deficiencies in the prior art, the present invention provides a Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough, as well as a preparation method and application thereof. The Chinese medicine composition has good therapeutic effects on symptoms such as cough, excessive phlegm, chest tightness, wheezing, heaviness and fatigue, and can effectively solve the problems existing in existing drugs.

[0008] To achieve the above purpose, the technical solution adopted by the present invention to solve the technical problem is:

[0009] A Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough comprises the following components in parts by weight: 140-190 parts of perilla seeds, 140-190 parts of mustard seeds, 140-190 parts of radish seeds, 80-120 parts of arisaema, 140-190 parts of magnolia bark, 140-190 parts of peucedanum, 170-230 parts of tangerine peel, 140-190 parts of tangerine peel, 220-280 parts of tuckahoe, 220-280 parts of platycodon and 80-120 parts of liquorice.

[0010] Further, the invention comprises the following components in parts by weight: 150-170 parts of perilla seeds, 150-170 parts of mustard seeds, 150-170 parts of radish seeds, 90-110 parts of arisaema, 150-170 parts of magnolia bark, 150-170 parts of peucedanum, 190-210 parts of tangerine peel, 150-170 parts of tangerine peel, 240-270 parts of poria, 240-260 parts of platycodon and 90-110 parts of liquorice.

[0011] Further, the invention comprises the following components in parts by weight: 150 parts of perilla seeds, 150 parts of mustard seeds, 170 parts of radish seeds, 90 parts of arisaema, 170 parts of magnolia bark, 170 parts of peucedanum, 190 parts of tangerine peel, 170 parts of tangerine peel, 240 parts of poria, 260 parts of platycodon and 90 parts of liquorice.

[0012] Further, the invention comprises the following components in parts by weight: 170 parts of perilla seeds, 150 parts of mustard seeds, 150 parts of radish seeds, 110 parts of arisaema, 150 parts of magnolia bark, 150 parts of peucedanum, 210 parts of tangerine peel, 150 parts of tangerine peel, 270 parts of poria, 240 parts of platycodon and 110 parts of liquorice.

[0013] Further, the invention comprises the following components in parts by weight: 160 parts of perilla seeds, 160 parts of mustard seeds, 160 parts of radish seeds, 100 parts of arisaema, 160 parts of magnolia bark, 160 parts of peucedanum, 200 parts of tangerine peel, 160 parts of tangerine peel, 260 parts of poria, 250 parts of platycodon and 100 parts of liquorice.

[0014] Furthermore, the perilla seeds are fried perilla seeds, the mustard seeds are fried mustard seeds, the radish seeds are fried radish seeds, the arisaema is processed arisaema, and the magnolia bark is ginger magnolia bark.

[0015] Furthermore, it includes the steps of crushing the raw materials and mixing them; or mixing the raw materials or extracting them separately to obtain an extract; or further refining and purifying the extract to obtain an effective ingredient; or adding pharmaceutically acceptable excipients to the extract / effective ingredient.

[0016] Furthermore, the dosage form is one of pills, granules, capsules, powders, mixtures, oral liquids or pastes.

[0017] Furthermore, the specific preparation method includes: the above eleven herbs, fried radish seeds, fried mustard seeds are roughly crushed, and boiled together with the remaining nine herbs in water, the decoction is filtered, the filtrate is combined, and concentrated under reduced pressure to a clear paste, which is granulated with an appropriate amount of pharmaceutically acceptable excipients to obtain the product.

[0018] The beneficial effects produced by the present invention are:

[0019] In the prescription, the stir-fried mustard seeds warm the lungs and promote qi, relieve phlegm, stir-fried perilla seeds lower qi and calm asthma, resolve phlegm and relieve cough, and stir-fried radish seeds can help digestion and relieve stagnation, promote qi and remove phlegm. All three medicines can promote qi and are commonly used medicines for treating phlegm and regulating qi. When used together, they can make qi smooth and eliminate phlegm, resolve food accumulation, and relieve cough and asthma. They are the main medicines. The processed arisaema is bitter, pungent, warm, and can dry dampness and resolve phlegm, dispel wind and relieve spasm. It can treat phlegm and dampness congestion, especially its warm and dry nature, and has a strong expectorant effect. The ginger and magnolia bark lower qi and calm asthma, widen the chest and eliminate fullness. The peucedanum chinense promotes the descending of qi in the lungs, removes phlegm and relieves cough. The three medicines are used together to help the three seeds lower qi, remove phlegm and calm asthma, and are the assistant medicines. Tangerine peel and tangerine peel regulate qi, dry dampness and eliminate phlegm. Drying dampness helps the processed arisaema to resolve phlegm. Regulating qi can make qi smooth and eliminate phlegm. Phlegm is generated by dampness, which comes from the spleen, so Poria is used to strengthen the spleen and drain dampness, so that dampness can be removed and qi can be strong, and phlegm cannot be generated. Therefore, the above three medicines are used as adjuvants. Licorice and Platycodon grandiflorum are used as guiding medicines. Licorice harmonizes the properties of the medicine and moistens the lungs and harmonizes the middle; Platycodon grandiflorum is a boat medicine that guides the medicine into the lungs. The combination of these medicines takes into account both the symptoms and the root cause, dries dampness, resolves phlegm, relieves asthma, regulates qi and harmonizes the middle, and is an effective prescription for removing phlegm and resolving fluid. DETAILED DESCRIPTION

[0020] In order to make the purpose, technical scheme and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention, that is, the embodiments described are only part of the embodiments of the present invention, rather than all of the embodiments.

[0021] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present invention.

[0022] It should be noted that relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprises" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0023] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0024] Example 1

[0025] A traditional Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough is prepared from the following components in parts by weight: 140g of stir-fried perilla seeds, 160g of stir-fried mustard seeds, 190g of stir-fried radish seeds, 80g of processed arisaema, 190g of ginger magnolia bark, 170g of peucedanum chinense, 170g of tangerine peel, 190g of tangerine peel, 220g of tuckahoe, 280g of platycodon grandiflorum and 80g of liquorice.

[0026] The preparation method of the above-mentioned Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough specifically comprises the following steps: the above eleven herbs, fried radish seeds and fried mustard seeds are coarsely crushed, and are decocted twice with water together with the remaining nine herbs. The first time, 10 times the amount of water is added, decocted for 1 hour, and filtered; the second time, 8 times the amount of water is added, decocted for 1 hour, the decoction is filtered, the filtrate is combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.15 (60°C), and granulated in one step with an appropriate amount of dextrin to make 1000g.

[0027] Example 2

[0028] A traditional Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough is prepared from the following components in parts by weight: 190g of stir-fried perilla seeds, 140g of stir-fried mustard seeds, 160g of stir-fried radish seeds, 120g of processed arisaema, 140g of ginger magnolia bark, 190g of peucedanum, 230g of tangerine peel, 140g of tangerine peel, 280g of tuckahoe, 220g of platycodon and 120g of liquorice.

[0029] The preparation method of the above-mentioned Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough specifically comprises the following steps: the above eleven herbs, fried radish seeds and fried mustard seeds are coarsely crushed, and are decocted twice with water together with the remaining nine herbs. The first time, 10 times the amount of water is added, decocted for 1 hour, and filtered; the second time, 8 times the amount of water is added, decocted for 1 hour, the decoction is filtered, the filtrate is combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.25 (60°C), and granulated in one step with an appropriate amount of dextrin to make 1000g.

[0030] Example 3

[0031] A traditional Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough is prepared from the following components in parts by weight: 150g of stir-fried perilla seeds, 150g of stir-fried mustard seeds, 170g of stir-fried radish seeds, 90g of processed arisaema, 170g of ginger magnolia bark, 170g of peucedanum, 190g of tangerine peel, 170g of tangerine peel, 240g of tuckahoe, 260g of platycodon and 90g of liquorice.

[0032] The preparation method of the above-mentioned Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough specifically comprises the following steps: the above eleven herbs, fried radish seeds and fried mustard seeds are coarsely crushed, and are decocted twice with water together with the remaining nine herbs. The first time, 10 times the amount of water is added, decocted for 1 hour, and filtered; the second time, 8 times the amount of water is added, decocted for 1 hour, the decoction is filtered, the filtrate is combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.20 (60°C), and granulated in one step with an appropriate amount of dextrin to make 1000g.

[0033] Example 4

[0034] A traditional Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough is prepared from the following components in parts by weight: 170g of stir-fried perilla seeds, 150g of stir-fried mustard seeds, 150g of stir-fried radish seeds, 110g of processed arisaema, 150g of ginger magnolia bark, 150g of peucedanum, 210g of tangerine peel, 150g of tangerine peel, 270g of tuckahoe, 240g of platycodon and 110g of liquorice.

[0035] The preparation method of the above-mentioned Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough specifically comprises the following steps: the above eleven herbs, fried radish seeds and fried mustard seeds are coarsely crushed, and are decocted twice with water together with the remaining nine herbs. The first time, 10 times the amount of water is added, decocted for 1 hour, and filtered; the second time, 8 times the amount of water is added, decocted for 1 hour, the decoction is filtered, the filtrate is combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.20 (60°C), and granulated in one step with an appropriate amount of dextrin to make 1000g, and 1000g is obtained.

[0036] Example 5

[0037] A traditional Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough is prepared from the following components in parts by weight: 160g of stir-fried perilla seeds, 160g of stir-fried mustard seeds, 160g of stir-fried radish seeds, 100g of processed arisaema, 160g of ginger magnolia bark, 160g of peucedanum, 200g of tangerine peel, 160g of tangerine peel, 260g of tuckahoe, 250g of platycodon and 100g of liquorice.

[0038] The preparation method of the above-mentioned Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough specifically comprises the following steps: the above eleven herbs, fried radish seeds and fried mustard seeds are coarsely crushed, and are decocted twice with water together with the remaining nine herbs. The first time, 10 times the amount of water is added, decocted for 1 hour, and filtered; the second time, 8 times the amount of water is added, decocted for 1 hour, the decoction is filtered, the filtrate is combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.20 (60°C), and granulated in one step with an appropriate amount of dextrin to make 1000g.

[0039] Comparative Example 1

[0040] A traditional Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough is prepared from the following components in parts by weight: 160g of stir-fried perilla seeds, 160g of stir-fried mustard seeds, 160g of stir-fried radish seeds, 100g of pinellia tuber, 160g of immature bitter orange, 160g of white scutellaria, 200g of tangerine peel, 160g of tangerine peel, 260g of poria, 250g of platycodon and 100g of liquorice.

[0041] The preparation method of the above-mentioned Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough specifically comprises the following steps: the above eleven herbs, fried radish seeds and fried mustard seeds are coarsely crushed, and are decocted twice with water together with the remaining nine herbs. The first time, 10 times the amount of water is added, decocted for 1 hour, and filtered; the second time, 8 times the amount of water is added, decocted for 1 hour, the decoction is filtered, the filtrate is combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.20 (60°C), and granulated in one step with an appropriate amount of dextrin to make 1000g.

[0042] Comparative Example 2

[0043] A traditional Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough is prepared from the following components in parts by weight: 160g of stir-fried perilla seeds, 160g of stir-fried mustard seeds, 160g of stir-fried radish seeds, 100g of processed arisaema, 160g of ginger magnolia bark, 160g of peucedanum, 200g of fructus aurantii, 160g of tangerine peel, 260g of poria, 120g of platycodon and 100g of liquorice.

[0044] The preparation method of the above-mentioned Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough specifically comprises the following steps: the above eleven herbs, fried radish seeds and fried mustard seeds are coarsely crushed, and are decocted twice with water together with the remaining nine herbs. The first time, 10 times the amount of water is added, decocted for 1 hour, and filtered; the second time, 8 times the amount of water is added, decocted for 1 hour, the decoction is filtered, the filtrate is combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.20 (60°C), and granulated in one step with an appropriate amount of dextrin to make 1000g.

[0045] Test example

[0046] 1. General Information

[0047] Patients who visited our hospital and were diagnosed were randomly selected, including 90 patients with chronic bronchitis, 90 patients with emphysema, and 90 patients with asthma.

[0048] 2. Disease diagnostic criteria

[0049] (1) Chronic bronchitis

[0050] Symptoms:

[0051] Cough: Chronic recurrent cough, usually more severe in the morning after waking up and lighter during the day, with cough suppressants or expectorants before going to bed;

[0052] Sputum: Sputum is usually white mucous sputum or serous foamy sputum, and yellow purulent sputum may also appear, and the amount of sputum will increase;

[0053] Wheezing or shortness of breath: accompanied by wheezing symptoms, especially during acute exacerbations, the wheezing symptoms are more obvious, and in severe cases, shortness of breath will occur and worsen after activity.

[0054] Auxiliary examination standards: X-ray examination: There may be no abnormalities in the early stage. As the disease progresses, the lung texture may become thicker and disordered, presenting reticular, cord-like, or spotted shadows, which are more obvious in the lower lung fields.

[0055] Pulmonary function test: When the small airway is obstructed, the maximum expiratory flow rate-volume curve at 75% and 50% lung capacity can significantly reduce the flow, and the closed air volume can increase. When the airway is narrowed or blocked, the pulmonary function manifestations of obstructive ventilation dysfunction will appear, such as the forced expiratory volume in the first second (FEV1). 1 ) / Forced vital capacity (FVC) < 70% and FEV 1 <80% expected value, etc.

[0056] Blood test: In case of bacterial infection, the total white blood cell count and neutrophil count increase, and the eosinophil count may increase in patients with wheezing. There is usually no change during the remission period.

[0057] Sputum examination: Smear or culture can show pathogens such as Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, etc. A large number of neutrophils and destroyed goblet cells can be seen in the smear, and more eosinophils are common in wheezing patients.

[0058] (2) Emphysema

[0059] Clinical manifestations: Dyspnea: In the early stage, dyspnea occurs after strenuous activities. As the disease progresses, dyspnea may also be felt during daily activities or even during rest, manifested as labored breathing, rapid breathing, wheezing, etc.

[0060] Cough and sputum: often accompanied by chronic cough, mostly intermittent, cough is more obvious when getting up in the morning, sputum is generally white mucous sputum or serous foamy sputum, when combined with infection, sputum volume increases, may be purulent sputum;

[0061] Other symptoms: When the symptoms are severe, patients may experience systemic symptoms such as weight loss, loss of appetite, fatigue, depression or anxiety. Some patients may experience hypoxia manifestations such as cyanosis of the lips and nails.

[0062] Auxiliary examination: Chest X-ray: increased lung translucency, sparse and thin lung texture, increased anteroposterior diameter of the thorax, widened intercostal space, flat diaphragm, vertical heart, and widened retrosternal space can be seen on lateral views;

[0063] Chest CT: It can show lung lesions more clearly, including destruction of lung tissue, formation of bullae, decreased density of lung parenchyma, thinning and sparse blood vessel texture, etc. It is of great significance for the diagnosis, classification and severity assessment of emphysema.

[0064] Pulmonary function test: It is the gold standard for diagnosing emphysema. The main indicators include forced expiratory volume in the first second (FEV 1 ), forced vital capacity (FVC), FEV 1 / FVC, residual volume (RV), total lung capacity (TLC), etc. FEV 1 / FVC<70%, it can be determined as persistent airflow limitation, and combined with RV / TLC>40%, it can be diagnosed as emphysema.

[0065] (3) Asthma

[0066] Clinical manifestations: Wheezing: It is the main symptom of asthma, manifested as paroxysmal expiratory dyspnea, accompanied by wheezing, rapid airflow and labored breathing, especially when exhaling, similar to the sound of a whistle or bellows;

[0067] Cough: It is often an irritating dry cough or accompanied by a small amount of white mucus sputum. The cough may worsen at night or in the early morning. Some patients may have cough as the only symptom, which is called cough variant asthma.

[0068] Chest tightness: Patients may feel a sense of oppression and tightness in the chest, as if a heavy object is pressing on the chest. In severe cases, this may affect normal breathing and activities.

[0069] Auxiliary examination:

[0070] Pulmonary function tests

[0071] Ventilatory function test: obstructive ventilatory dysfunction during the attack, forced expiratory volume in the first second (FEV 1 ), the ratio of forced expiratory volume in one second to forced vital capacity (FEV 1 / FVC) and peak expiratory flow (PEF) decreased;

[0072] Bronchial provocation test (BPT): used to measure airway responsiveness and is applicable to FEV 1 After inhalation of the provocative agent, if FEV 1 A decrease of ≥20% is positive, indicating airway hyperresponsiveness and helpful for the diagnosis of asthma;

[0073] Bronchodilator test (BDT): used to evaluate the reversibility of airway changes after inhalation of a bronchodilator. 1 An increase of ≥12% compared to before medication and an absolute increase of ≥200ml is considered positive, indicating that airway obstruction is reversible, which is of great significance for the diagnosis of asthma.

[0074] PEF and its variability measurement: PEF can reflect the changes in airway ventilation function. The diurnal variability of PEF in asthma patients is ≥20%, which is helpful for diagnosis.

[0075] Chest imaging examination: During an asthma attack, chest X-ray or CT examination may show increased and disordered lung texture or signs of emphysema, but most patients may not have obvious abnormalities in chest X-rays during remission. For some atypical cases, imaging examinations can help rule out other lung diseases.

[0076] 3. Inclusion criteria

[0077] Chronic bronchitis, emphysema, asthma:

[0078] (1) Age range: 18-75 years old, regardless of gender.

[0079] (2) Meet the diagnostic criteria for chronic bronchitis, emphysema, or asthma and be in a stable phase (no acute exacerbation in the past 4 weeks).

[0080] (3) Voluntarily signed the informed consent form and had good compliance

[0081] 4. Exclusion criteria

[0082] Chronic bronchitis, emphysema, asthma:

[0083] (1) Combined with other respiratory diseases.

[0084] (2) Severe complications: heart failure (NYHA grade III-IV), liver and kidney failure (ALT / AST>3 times normal value, eGFR<30mL / min).

[0085] (3) Allergy history: Allergy to test drug ingredients.

[0086] (4) Pregnant or lactating women.

[0087] (5) Participation in other clinical trials recently (within 3 months).

[0088] (6) Others: long-term use of immunosuppressants or systemic glucocorticoids.

[0089] 5. Treatment methods

[0090] Different patients were randomly divided into three groups, and each group of patients was respectively given the drugs in Example 5 and Comparative Examples 1-2, 10 g each time, three times a day, for 3 consecutive weeks, and the disease conditions of the patients were observed.

[0091] 6. Efficacy evaluation criteria

[0092] (1) Chronic bronchitis:

[0093] Clinical recovery: symptoms of cough, sputum and wheezing disappear, and the patient can work and live normally;

[0094] Effective: Cough, sputum and asthma symptoms are alleviated, and respiratory function is improved;

[0095] Ineffective: No improvement in symptoms and signs.

[0096] Total effective rate = (number of clinically cured patients + number of effective patients) / total number of patients * 100%

[0097] (2) Emphysema:

[0098] Clinical recovery: clinical symptoms and signs such as dyspnea, cough, and sputum disappear, and examination results are basically normal;

[0099] Effective: clinical symptoms and signs such as dyspnea, cough, and sputum production have improved, and examination results have improved;

[0100] Ineffective: There was no significant change in clinical symptoms and signs such as dyspnea, cough, and sputum, and there was no significant improvement in examination results.

[0101] Total effective rate = (number of clinically cured patients + number of effective patients) / total number of patients * 100%

[0102] (3) Asthma:

[0103] Clinical recovery: clinical symptoms and signs such as wheezing, coughing, and chest tightness have basically disappeared, and examination results are basically normal;

[0104] Effective: clinical symptoms and signs such as wheezing, coughing, and chest tightness have improved, and examination results have improved;

[0105] Ineffective: There is no significant change in clinical symptoms and signs such as wheezing, coughing, and chest tightness, and there is no significant change in examination results;

[0106] Total effective rate = (number of clinically cured patients + number of effective patients) / total number of patients * 100%

[0107] 7. Efficacy results

[0108] (1) The results of treatment of chronic bronchitis are shown in Table 1;

[0109] Table 1:

[0110] Group Clinically cured (person) Effective (person) Invalid (person) Total effective rate (%) Example 5 20 9 1 96.7 Comparative Example 1 6 15 9 70.0 Comparative Example 2 8 11 11 63.3

[0111] (2) The results of emphysema treatment are shown in Table 2;

[0112] Table 2:

[0113] Group Clinically cured (person) Effective (person) Invalid (person) Total effective rate (%) Example 5 22 8 0 100 Comparative Example 1 7 13 10 66.7 Comparative Example 2 6 14 10 66.7

[0114] (3) Asthma treatment results are shown in Table 3;

[0115] Table 3:

[0116] Group Clinically cured (person) Effective (person) Invalid (person) Total effective rate (%) Example 5 21 8 1 96.7 Comparative Example 1 6 12 12 60.0 Comparative Example 2 5 11 14 53.3

[0117] The results in Tables 1-3 show that the drug in Example 5 has a good therapeutic effect on symptoms such as cough and sputum caused by chronic bronchitis, emphysema and asthma. Although the drug in Comparative Example 1-2 also has a certain therapeutic effect, the therapeutic effect is worse than that of the drug in Example 5. It is speculated that the possible reason is that after adjusting the formula composition of the composition, the interaction and complementary effects between different medicinal materials in the composition are weakened or disappeared, thereby affecting the therapeutic effect.

[0118] Typical Cases

[0119] Case 1: Mr. Wang, male, 46 years old, came to our hospital for treatment in March 2021. He reported that he had repeated coughing and sputum for more than 2 years, with attacks for 3-4 months each year. He was diagnosed with chronic bronchitis and had taken Western medicine for treatment, but the effect was not obvious and the disease was prone to relapse after stopping the medicine. The medicine in Example 5 was prescribed for him and he was asked to take it for 4 consecutive weeks. The patient reported in the follow-up visit that the symptoms such as coughing and sputum were under control, and he continued to take the medicine until the symptoms disappeared. The results were followed up one year later, and the patient reported that a relapse had occurred.

[0120] Case 2: Liu Moumou, female, 62 years old, came to our hospital for treatment in November 2022. She reported that she had repeated cough, sputum, asthma, and chest tightness for many years. She had taken a variety of chemical drugs and traditional Chinese medicines for treatment, but the symptoms were prone to relapse after stopping the drugs. She was prescribed the drug in Example 5 for 4 consecutive weeks. During the follow-up visit, the patient reported that the symptoms such as cough, asthma, and chest tightness had basically improved. The drug was continued to be prescribed until the symptoms disappeared. The results were followed up one year later, and the patient reported that there was no relapse.

[0121] Case 3: Zhang, female, 55 years old, came to our hospital for treatment in December 2022. She reported that she had cough, wheezing, and chest tightness for many years. She took various medications during this period, but was not cured. The patient was prescribed the drug in Example 5 and took it for 4 consecutive weeks. The patient reported that her symptoms had improved significantly during the follow-up visit. She continued to take the drug until she recovered. The results were followed up one year later, and the patient reported that there was no recurrence.

[0122] Case 4: Zhang XX, male, 57 years old, came to our hospital for treatment in February 2023. He reported coughing, sputum, and dyspnea, which worsened at night. He took multiple medications with general poor results. The drug in Example 5 was prescribed for him. After taking it for 4 consecutive weeks, the patient reported that his symptoms were relieved during the follow-up visit. He continued to take the drug until he recovered. The effect was followed up after 9 months, and the patient reported that there was no recurrence.

Claims

1. A Chinese medicine composition for drying dampness and resolving phlegm, regulating qi and relieving cough, characterized in that: The invention comprises the following components in parts by weight: 140-190 parts of perilla seeds, 140-190 parts of mustard seeds, 140-190 parts of radish seeds, 80-120 parts of arisaema, 140-190 parts of magnolia bark, 140-190 parts of peucedanum, 170-230 parts of tangerine peel, 140-190 parts of tangerine peel, 220-280 parts of tuckahoe, 220-280 parts of platycodon and 80-120 parts of liquorice.

2. The Chinese medicine composition for drying dampness and eliminating phlegm, regulating qi and relieving cough as claimed in claim 1, characterized in that: The invention comprises the following components in parts by weight: 150-170 parts of perilla seeds, 150-170 parts of mustard seeds, 150-170 parts of radish seeds, 90-110 parts of arisaema, 150-170 parts of magnolia bark, 150-170 parts of peucedanum, 190-210 parts of tangerine peel, 150-170 parts of tangerine peel, 240-270 parts of tuckahoe, 240-260 parts of platycodon and 90-110 parts of liquorice.

3. The Chinese medicine composition for drying dampness and eliminating phlegm, regulating qi and relieving cough as claimed in claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 150 parts of perilla seeds, 150 parts of mustard seeds, 170 parts of radish seeds, 90 parts of arisaema, 170 parts of magnolia bark, 170 parts of peucedanum, 190 parts of tangerine peel, 170 parts of tangerine peel, 240 parts of tuckahoe, 260 parts of platycodon and 90 parts of liquorice.

4. The Chinese medicine composition for drying dampness and eliminating phlegm, regulating qi and relieving cough as claimed in claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 170 parts of perilla seeds, 150 parts of mustard seeds, 150 parts of radish seeds, 110 parts of arisaema, 150 parts of magnolia bark, 150 parts of peucedanum, 210 parts of tangerine peel, 150 parts of tangerine peel, 270 parts of tuckahoe, 240 parts of platycodon and 110 parts of liquorice.

5. The Chinese medicine composition for drying dampness and eliminating phlegm, regulating qi and relieving cough as claimed in claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 160 parts of perilla seeds, 160 parts of mustard seeds, 160 parts of radish seeds, 100 parts of arisaema, 160 parts of magnolia bark, 160 parts of peucedanum, 200 parts of tangerine peel, 160 parts of tangerine peel, 260 parts of tuckahoe, 250 parts of platycodon and 100 parts of liquorice.

6. The Chinese medicine composition for drying dampness and eliminating phlegm, regulating qi and relieving cough according to claim 1, characterized in that: The perilla seeds are fried perilla seeds, the mustard seeds are fried mustard seeds, the radish seeds are fried radish seeds, the arisaema is processed arisaema, and the magnolia bark is ginger magnolia bark.

7. A method for preparing the Chinese medicinal composition for drying dampness and resolving phlegm, regulating qi and relieving cough according to any one of claims 1 to 6, characterized in that: It includes the steps of crushing and mixing the raw materials; or the extract obtained by mixing or extracting the raw materials separately; or the active ingredient obtained by further refining and purifying the extract; or the extract / active ingredient is added with pharmaceutically acceptable excipients.

8. The method for preparing the Chinese medicine composition for drying dampness and eliminating phlegm, regulating qi and relieving cough as claimed in claim 7, characterized in that: The dosage form is one of pills, granules, capsules, powders, mixtures, oral liquids or pastes.

9. The method for preparing the Chinese medicine composition for drying dampness and eliminating phlegm, regulating qi and relieving cough as claimed in claim 8, characterized in that: The specific preparation method includes: coarsely chopping the above eleven herbs, stir-fried radish seeds and stir-fried mustard seeds, boiling them together with the remaining nine herbs in water, filtering the decoction, combining the filtrate, concentrating under reduced pressure to a clear paste, granulating with an appropriate amount of pharmaceutically acceptable excipients, and obtaining the product.

10. Use of the composition of claims 1-6 in the preparation of medicines for drying dampness and resolving phlegm, regulating qi and relieving cough.