Disinfectant and preparation method thereof

Abstract

The invention relates to a disinfectant and a preparation method thereof, and belongs to the technical field of animal husbandry, the disinfectant comprises the following components by weight: 20-50 parts of sodium dichloroisocyanurate, 10-30 parts of an anionic surfactant, 4-12 parts of polyethylene glycol, 1-10 parts of an auxiliary agent and 8-25 parts of anhydrous sodium sulfate, and the auxiliary agent is cardanol cationic surfactant coated modified silica. The disinfectant based on the technical scheme of the invention not only has strong foaming ability, but also improves the stability of foam and increases the maintenance time of the foam by adding polyethylene glycol and an auxiliary agent, thereby prolonging the effective disinfection time of sodium dichloroisocyanurate and improving the disinfection effect.

Description

Technical Field

[0001] The present invention belongs to the technical field of animal husbandry, and particularly relates to a disinfectant and a preparation method thereof. Background Art

[0002] Sodium dichloroisocyanurate (DCCNa), with the molecular formula C 3 Cl 2 N 3 NaO 3 , is a white powdery crystal or granule at room temperature, with a chlorine odor. It is the most broad-spectrum, efficient, and safe disinfectant among oxidative bactericides, and can strongly kill various pathogenic microorganisms such as viruses, bacterial spores, bacterial vegetative cells, and fungi. It is widely used for drinking water disinfection, preventive disinfection, and environmental disinfection of various places.

[0003] In large-scale animal breeding farms, biological safety management has become a top priority, making sodium dichloroisocyanurate play an important role in the biological safety prevention and control of breeding farms. However, the effective action time of sodium dichloroisocyanurate disinfectant is relatively short (usually 20 - 30 minutes), and due to different natural environments in various regions, it is difficult to master the effective action time of disinfection well.

[0004] In the prior art, the method of repeated spraying is usually adopted to ensure the disinfection effect. Although thorough disinfection can be achieved in this way, excessive use of disinfectant products not only causes certain irritation to the skin and mucous membranes of operators and breeding animals, but also has a certain impact on the natural environment. Summary of the Invention

[0005] In view of the above situation, to overcome at least some defects of the above prior art, the present invention provides a disinfectant and a preparation method thereof.

[0006] To achieve the above object, the technical solution adopted by the present invention is as follows: The present invention provides a disinfectant, comprising the following components in parts by weight: 20 - 50 parts of sodium dichloroisocyanurate, 10 - 30 parts of anionic surfactant, 4 - 12 parts of polyethylene glycol, 1 - 10 parts of an auxiliary agent, and 8 - 25 parts of anhydrous sodium sulfate; the auxiliary agent is cashew phenol cationic surfactant-coated modified silica.

[0007] In some embodiments, the anionic surfactant includes at least one of sodium dodecyl sulfate, fatty alcohol polyoxyethylene ether sulfate, α-olefin sulfonate, and sodium carboxymethyl cellulose.

[0008] The present invention also provides a preparation method of the disinfectant, comprising: Sequentially adding the anionic surfactant into anhydrous sodium sulfate for premixing; Mix the premixed components with polyethylene glycol, sodium dichloroisocyanurate and an auxiliary agent evenly to obtain a disinfectant.

[0009] In some embodiments, the preparation method of the auxiliary agent includes: Take tetraethyl orthosilicate and add it to an alkaline solution, react at 40°C - 50°C for 2h - 3h. After the reaction is completed, add cardanol cationic surfactant and react for 2h - 3h. After the reaction is completed, centrifuge for purification, wash, and dry to obtain the auxiliary agent.

[0010] In some embodiments, the alkaline solution is prepared from ethanol, deionized water and ammonia water; and / or, the pH value of the alkaline solution is 8 - 11.

[0011] In some embodiments, the preparation method of the cardanol cationic surfactant includes: Add cardanol and 1,8 - dibromooctane to isopropanol, react at 90°C - 100°C for 10h - 15h under alkaline conditions to obtain brominated cardanol ether; Add brominated cardanol ether and dimethyldodecylamine to acetonitrile, react at 50°C - 60°C for 20h - 30h to obtain cardanol cationic surfactant.

[0012] In some embodiments, the molar ratio of cardanol to 1,8 - dibromooctane is 1:1.2 - 1.6.

[0013] In some embodiments, the molar ratio of brominated cardanol ether to dimethyldodecylamine is 1:2 - 2.5.

[0014] In some embodiments, the alkaline condition is formed by adding potassium carbonate to isopropanol, and the molar ratio of cardanol to potassium carbonate is 1:2 - 2.5.

[0015] The beneficial effects achieved by the present invention are as follows: By compounding sodium dichloroisocyanurate with an anionic surfactant, the present invention can generate a disinfection foam, thereby extending the effective disinfection time of sodium dichloroisocyanurate, fully exerting the disinfection activity of sodium dichloroisocyanurate, and at the same time avoiding the environmental impact caused by excessive disinfection.

[0016] The disinfectant based on the technical solution of the present invention not only has strong foaming ability, but also improves the stability of the foam and increases the foam maintenance time by adding polyethylene glycol and an auxiliary agent, thereby extending the effective disinfection time of sodium dichloroisocyanurate and enhancing the disinfection effect. Detailed implementation manners

[0017] Next, in combination with the embodiments of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts belong to the scope of protection of the present invention.

[0018] Unless otherwise defined, all professional and scientific terms used herein have the same meaning as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to the described content can be applied to the present invention. The preferred methods and materials described herein are only for illustrative purposes and do not limit the content of this application.

[0019] In view of the deficiencies in the prior art mentioned in the background art, the first aspect of the embodiments of the present invention provides a disinfectant, which includes the following components in parts by weight: 20-50 parts of sodium dichloroisocyanurate, 10-30 parts of anionic surfactant, 4-12 parts of polyethylene glycol, 1-10 parts of an auxiliary agent, and 8-25 parts of anhydrous sodium sulfate; the auxiliary agent is silica modified by coating with cardanol cationic surfactant.

[0020] Since the sprayed disinfection liquid flows away immediately after spraying and has a short action time, the compounding of sodium dichloroisocyanurate and an anionic surfactant can generate disinfection foam. The foam can effectively cover the surface of the object and penetrate into fine gaps. Thus, according to the thickness of the foam, multiple layers of foam can overlap at the edges of the poultry house, feeding troughs, corners and other parts for key disinfection, making the disinfection have quantifiable and controllable indicators and stronger intuitiveness. At the same time, the foam has a long adhesion time, which can extend the action time of the disinfectant liquid and microorganisms and enhance the disinfection effect.

[0021] Among them, the anionic surfactant has the advantages of fast foaming speed and large foam volume, and the cost is relatively low. However, the foam generated by it has insufficient stability. By adding polyethylene glycol and an auxiliary agent, the stability of the foam can be improved, the foam maintenance time can be increased, and thus the effective disinfection time of sodium dichloroisocyanurate can be extended, effectively improving the disinfection effect.

[0022] Silica as nanoparticles can, without reducing the foaming performance, improve the foam stability by stacking between adjacent two bubbles to delay the liquid drainage and coarsening of the foam. Cardanol is a natural phenolic compound extracted from cashew nut shell liquid. Its molecule contains a benzene ring, a long-chain alkyl group (C15) and a hydroxyl group, and has excellent hydrophobicity and biodegradability. By chemically modifying to introduce cationic groups, an environmentally friendly cationic surfactant can be obtained. The cardanol cationic surfactant-coated modified silica introduces hydrophobic long chains on the silica surface, which can enhance its dispersibility and make the silica have moderate wettability, and can stably adsorb on the gas-liquid interface, thereby improving the foam stability.

[0023] Preferably, the anionic surfactant includes at least one of sodium dodecyl sulfate, sodium laureth sulfate, alpha-olefin sulfonate and sodium carboxymethyl cellulose.

[0024] In some embodiments, the disinfectant forms foam through a high-pressure washer and a foaming gun head and is sprayed, so that the disinfectant can be fully foamed, thereby fully exerting the effect of the disinfectant.

[0025] The present invention also provides a preparation method of a disinfectant, including: sequentially adding an anionic surfactant into anhydrous sodium sulfate for premixing; mixing the premixed components with polyethylene glycol, sodium dichloroisocyanurate and an auxiliary agent uniformly to obtain the disinfectant. Among them, mixing the anionic surfactant with anhydrous sodium sulfate can prevent the surfactant from caking due to moisture absorption and prevent the disinfectant from caking. Moreover, in the foam system, the ionic effect of sodium sulfate can reduce the critical micelle concentration (CMC) of the surfactant and enhance the foaming efficiency to a certain extent.

[0026] In some embodiments, the preparation method of the auxiliary agent includes: adding tetraethyl orthosilicate into an alkaline solution, reacting at 40°C - 50°C for 2h - 3h, adding a cardanol cationic surfactant after the reaction ends, reacting for 2h - 3h, centrifuging, purifying, washing and drying after the reaction ends to obtain the auxiliary agent. Since tetraethyl orthosilicate can hydrolyze to form silica under alkaline conditions, and the surface of the formed silica particles will show anionic characteristics in the alkaline solution, the positively charged cardanol cationic surfactant can combine with the negatively charged silica through electrostatic attraction, thereby preparing the auxiliary agent.

[0027] Preferably, the alkaline solution is prepared from ethanol, deionized water and ammonia water. Preferably, the pH value of the alkaline solution is 8 - 11. In the alkaline solution, tetraethyl orthosilicate has good solubility in ethanol, deionized water can catalyze the hydrolysis of tetraethyl orthosilicate, and the addition of ammonia water can adjust the pH value. By controlling the addition amount of ammonia water, the pH value of the alkaline solution can be controlled within 8 - 11, thereby avoiding insufficient hydrolysis of tetraethyl orthosilicate due to too small pH value and too violent reaction due to too large pH value.

[0028] In some embodiments, the preparation method of the cardanol cationic surfactant includes: Adding cardanol and 1,8 - dibromooctane into isopropanol, reacting at 90°C - 100°C for 10h - 15h under alkaline conditions to obtain brominated cardanol ether; Adding brominated cardanol ether and dimethyldodecylamine into acetonitrile, reacting at 50°C - 60°C for 20h - 30h to obtain the cardanol cationic surfactant.

[0029] The phenolic hydroxyl group of cardanol is deprotonated to generate an oxygen anion under alkaline conditions, and undergoes nucleophilic substitution on 1,8 - dibromooctane to form brominated cardanol ether. Isopropanol, as a polar solvent, promotes the reaction. Dimethyldodecylamine, as a nucleophile, attacks the bromine atom at the end of brominated cardanol ether to generate a quaternary ammonium salt. The quaternary ammonium salt structure has good antibacterial properties and can improve the antibacterial effect of the disinfectant.

[0030] Preferably, the molar ratio of cardanol to 1,8 - dibromooctane is 1:1.2 - 1.6. Among them, too little addition amount of 1,8 - dibromooctane will lead to too low reaction efficiency, and too much addition amount of 1,8 - dibromooctane will increase the amount of double - substitution by - products. By setting the molar ratio of cardanol to 1,8 - dibromooctane to 1:1.2 - 1.6, the reaction efficiency can be increased while reducing the amount of by - products.

[0031] Preferably, the molar ratio of brominated cardanol ether to dimethyldodecylamine is 1:2 - 2.5. Among them, too little addition amount of dimethyldodecylamine will lead to incomplete quaternization of brominated cardanol ether, and too much addition amount of dimethyldodecylamine will produce a large amount of unreacted amine, which is difficult to separate and remove. By setting the molar ratio of brominated cardanol ether to dimethyldodecylamine to 1:2 - 2.5, the quaternization of brominated cardanol ether can be complete and the separation of the product is facilitated.

[0032] In some embodiments, an alkaline condition is formed by adding potassium carbonate into isopropanol, and the molar ratio of cardanol to potassium carbonate is 1:2 - 2.5. Potassium carbonate added into the polar solvent (i.e., isopropanol) can provide a suitable alkaline condition and promote the deprotonation of phenol.

[0033] The present invention will be further described by way of specific embodiments.

[0034] In the experimental methods in the following examples, unless otherwise specified, they are all conventional methods; the test materials used in the following examples, unless otherwise specified, are all obtained by purchasing from commercial channels.

[0035] Example 1 A disinfectant comprises the following components in parts by weight: 20 parts of sodium dichloroisocyanurate, 10 parts of anionic surfactant, 4 parts of polyethylene glycol, 1 part of auxiliary agent, and 8 parts of anhydrous sodium sulfate.

[0036] The anionic surfactant includes sodium dodecyl sulfate, sodium fatty alcohol polyoxyethylene ether sulfate, α-olefin sulfonate, and sodium carboxymethyl cellulose, and the mass ratio is 1:1:1:1.

[0037] Preparation of cardanol cationic surfactant: Cardanol and 1,8-dibromooctane are added to isopropanol. The molar ratio of cardanol to 1,8-dibromooctane is 1:1.2, and potassium carbonate is added. The molar ratio of cardanol to potassium carbonate is 1:2. React at 90 °C for 10 h to obtain brominated cardanol ether; The brominated cardanol ether and dimethyldodecylamine are added to acetonitrile. The molar ratio of brominated cardanol ether to dimethyldodecylamine is 1:2. React at 50 °C for 20 h to obtain cardanol cationic surfactant.

[0038] Preparation of auxiliary agent: Take tetraethyl orthosilicate and add it to an alkaline solution with a pH value of 7. React at 40 °C for 2 h. After the reaction, add cardanol cationic surfactant and react for 2 h. After the reaction, centrifuge for purification, wash, and dry to obtain the auxiliary agent.

[0039] Preparation of disinfectant: Sodium dodecyl sulfate, sodium fatty alcohol polyoxyethylene ether sulfate, α-olefin sulfonate, and sodium carboxymethyl cellulose are successively added to anhydrous sodium sulfate for premixing; The premixed components are mixed uniformly with polyethylene glycol, sodium dichloroisocyanurate, and auxiliary agent to obtain the disinfectant.

[0040] Example 2 A disinfectant comprises the following components in parts by weight: 50 parts of sodium dichloroisocyanurate, 30 parts of anionic surfactant, 12 parts of polyethylene glycol, 10 parts of auxiliary agent, and 25 parts of anhydrous sodium sulfate.

[0041] The anionic surfactant includes sodium dodecyl sulfate, sodium fatty alcohol polyoxyethylene ether sulfate, α-olefin sulfonate, and sodium carboxymethyl cellulose, and the mass ratio is 1:1:1:1.

[0042] Preparation of cardanol cationic surfactant: Add cardanol and 1,8-dibromooctane into isopropanol. The molar ratio of cardanol to 1,8-dibromooctane is 1:1.6. Add potassium carbonate, and the molar ratio of cardanol to potassium carbonate is 1:2.5. React at 100 °C for 15 h to obtain brominated cardanol ether; Add brominated cardanol ether and dimethyldodecylamine into acetonitrile. The molar ratio of brominated cardanol ether to dimethyldodecylamine is 1:2.5. React at 60 °C for 30 h to obtain cardanol cationic surfactant.

[0043] Preparation of auxiliary agent: Take tetraethyl orthosilicate and add it into an alkaline solution with a pH value of 11. React at 50 °C for 3 h. After the reaction, add cardanol cationic surfactant and react for 3 h. After the reaction, centrifuge for purification, wash, and dry to obtain the auxiliary agent.

[0044] Preparation of disinfectant: Add sodium dodecyl sulfate, sodium lauryl polyoxyethylene ether sulfate, α-olefin sulfonate, and sodium carboxymethyl cellulose into anhydrous sodium sulfate in sequence for premixing; Mix the premixed components with polyethylene glycol, sodium dichloroisocyanurate, and the auxiliary agent evenly to obtain the disinfectant.

[0045] Example 3 It is the same as Example 1, except that the weight part of the auxiliary agent in the disinfectant is 2 parts.

[0046] Example 4 It is the same as Example 1, except that the weight part of the auxiliary agent in the disinfectant is 4 parts.

[0047] Example 5 It is the same as Example 1, except that the weight part of the auxiliary agent in the disinfectant is 6 parts.

[0048] Example 6 It is the same as Example 1, except that the weight part of the auxiliary agent in the disinfectant is 8 parts.

[0049] Comparative Example 1 It is the same as Example 1, except that no auxiliary agent is added to the disinfectant.

[0050] Test the disinfectants prepared in Examples 1-6 and Comparative Example 1. The specific test contents are as follows: Foaming test: Add 1 wt% of the disinfectant into 50 mL of deionized water, stir at 1000 r / min for 5 minutes, and record the foam volume and foam half-life of the disinfectant. The results are shown in Table 1.

[0051] Antibacterial test: Distribute bacteria and viruses (such as Escherichia coli, African swine fever virus, foot-and-mouth disease virus, avian influenza virus, etc.) on a glass plate, and distribute dirt such as grease, animal excrement, protein, rust spots, etc. on the glass plate as a test plate. Spray an equal amount of disinfectant on the treated test plate through a foam gun. After 30 minutes, rinse the test plate, monitor the residual amount of bacteria and viruses on the test plate, calculate the sterilization rate, and at the same time observe whether there is any impurity residue. The results are shown in Table 1.

[0052] Table 1

[0053] As can be seen from Table 1, the disinfectants prepared in Examples 1-6 have excellent foaming ability, foam stability and antibacterial effect. The excellent foaming ability and foam stability endow it with good cleaning ability. For the disinfectant prepared in Comparative Example 1, due to the absence of additives, the foaming ability and foam stability decreased significantly, the antibacterial effect weakened, and the cleaning ability also decreased.

[0054] The above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention, and they should all be covered by the protection scope of the present invention.

Claims

1. A disinfectant, characterized in that: The invention comprises the following components in parts by weight: 20-50 parts of sodium dichloroisocyanurate, 10-30 parts of anionic surfactant, 4-12 parts of polyethylene glycol, 1-10 parts of auxiliary agent and 8-25 parts of anhydrous sodium sulfate; The auxiliary agent is cardanol cationic surfactant coated modified silicon dioxide.

2. The disinfectant according to claim 1, characterized in that The anionic surfactant includes at least one of sodium lauryl sulfate, sodium fatty alcohol polyoxyethylene ether sulfate, sodium α-olefin sulfonate and sodium carboxymethyl cellulose.

3. A method for preparing a disinfectant according to claim 1, characterized in that: include: The anionic surfactants are sequentially added into anhydrous sodium sulfate for premixing; The premixed components are uniformly mixed with polyethylene glycol, sodium dichloroisocyanurate and an auxiliary agent to obtain a disinfectant.

4. The preparation method according to claim 3, characterized in that: The preparation method of the auxiliary agent comprises: Take ethyl orthosilicate and add it to an alkaline solution, react at 40°C-50°C for 2h-3h, add cardanol cationic surfactant after the reaction, react for 2h-3h, centrifuge and purify after the reaction, wash, and dry to obtain an auxiliary agent.

5. The preparation method according to claim 4, characterized in that: The alkaline solution is prepared from ethanol, deionized water and ammonia water; and / or the pH value of the alkaline solution is 8-11.

6. The preparation method according to claim 4, characterized in that: The preparation method of the cardanol cationic surfactant comprises: Adding cardanol and 1,8-dibromooctane to isopropanol, reacting at 90°C-100°C for 10h-15h under alkaline conditions to obtain bromocardanol ether; Bromocardol ether and dimethyldodecylamine were added into acetonitrile, and reacted at 50° C.-60° C. for 20 h-30 h to obtain a cardanol cationic surfactant.

7. The preparation method according to claim 6, characterized in that: The molar ratio of the cardanol to 1,8-dibromooctane is 1:1.2-1.

6.

8. The preparation method according to claim 6, characterized in that: The molar ratio of the brominated cardanol ether to dimethyl dodecylamine is 1:2-2.

5.

9. The preparation method according to claim 6, characterized in that: The alkaline condition is formed by adding potassium carbonate to isopropanol, and the molar ratio of cardanol to potassium carbonate is 1:2-2.5.

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