Insecticidal suspending agent composition

Abstract

The invention provides an insecticidal suspending agent composition compounded from diafenthiuron and dinotefuran, and the problem of generation overlapping of target insects can be solved by utilizing the ovicidal effect of diafenthiuron and the characteristic that dinotefuran has a special effect on piercing-sucking mouthpart pests. A three-stage grinding process is adopted in the production process, so that raw medicine particles can be finer, and the raw medicine particles can penetrate through air holes more easily to reach a target body; the synergistic additive is added after grinding and before subpackaging, so that the stability of the preparation can be improved, the plant-source synergistic additive is prevented from being decomposed, and the production cost is saved. The botanical synergistic auxiliary agent can greatly reduce the surface tension of a diluent, draw active compound particles, penetrate through a plant wax coat to directly reach a target to play a role, and can also prolong the adhesion time of a liquid medicine on the surface of a plant through a coating effect, delay the degradation of an active compound, prolong the lasting period and reduce the pesticide application frequency.

Description

Technical Field

[0001] The present invention relates to the field of pesticide formulations, and particularly to an insecticidal suspension concentrate composition of diafenthiuron and dinotefuran in combination. Background Art

[0002] At present, pests and diseases are one of the main reasons affecting crop yields. In agricultural production practices, applying chemical agents remains the most effective means of controlling crop pests and diseases. However, controlling crop pests and diseases with chemical agents can easily have a serious impact on the ecological environment: on the one hand, the large-scale application of chemical agents is likely to cause drug residues, severely polluting the air, water, and soil; on the other hand, the long-term high-dose application of a single chemical agent can easily cause target organisms such as phytopathogenic microorganisms and pests to develop drug resistance, and it will also affect the survival of natural enemy organisms. Several technical means can be used to alleviate or overcome the above problems. For example, using green and environmentally friendly pesticide formulations, reducing the use of toxic volatile organic solvents, and extending the effective period; carrying out reasonable pesticide compounding to expand the control spectrum, improve the control effect, thereby reducing the amount of pesticides used, reducing pesticide residues, and delaying the occurrence and development of target organism drug resistance. In addition to the inherent disadvantages of chemical agents themselves, there are also many problems in the application process. Limited by objective factors such as pesticide costs, external environments, and application technologies, the liquid interface properties of chemical agents are often not good. During the application process, the bouncing and loss of droplets are serious, resulting in poor adhesion and less deposition of the liquid medicine on the surface of target plants; in case of high temperature or strong wind weather, the evaporation and drift of the liquid medicine are serious, not only reducing the drug effect but also increasing the degree of environmental pollution. To address the above application problems, it can also be achieved by using special auxiliaries. For example, adding surfactants to reduce the surface tension to avoid the bouncing and loss of the liquid medicine on the leaf surface; applying vegetable oil auxiliaries to regulate the contact angle of the liquid medicine on the target to improve the adhesion on the leaves and delay the evaporation rate; adding high molecular polymer auxiliaries to improve the uniformity and sedimentation performance of the liquid medicine droplets and improve the pesticide utilization rate.

[0003] Therefore, developing pesticide compound formulations with excellent pest and disease control effects and featuring green environmental protection, high efficiency in application, etc. remains the main task that technicians in the pesticide field have long faced.

[0004] Diafenthiuron, with the English name Diafenthiuron, was first developed by Ciba-Geigy (now Syngenta) and is a thiourea-type insect growth regulator. The structural formula is as follows:

[0005] The molecular formula of diafenthiuron is C 23 H 32 N 2OS, with a relative molecular weight of 384.58, and its chemical name is 1-tert-butyl-3-(2,6-diisopropyl-4-phenoxyphenyl)thiourea. It is of low toxicity, but highly toxic to fish and bees. It inhibits the synthesis of chitin in the insect cuticle, and is a highly efficient insecticide and acaricide, having contact, stomach, systemic and fumigation effects, and also having a certain ovicidal effect. Diafenthiuron can effectively control pests resistant to carbamates, organophosphates, pyrethroids, etc., and can prevent and control aphids, whiteflies, leafhoppers, noctuid pests and mites on various crops and ornamental plants. Diafenthiuron can be formulated into various dosage forms such as wettable powders and emulsifiable concentrates.

[0006] Dinotefuran, with the English name Dinotefuran, is a third-generation nicotinic insecticide developed by Mitsui Chemicals, Japan. The structural formula is as follows:

[0007] The molecular formula of dinotefuran is C 7 H 14 N 4 O 3 , with a relative molecular weight of 202.21, and its chemical name is 1-methyl-2-nitro-3-(tetrahydro-3-furanylmethyl)guanidine. It is a nicotinic acetylcholine receptor stimulant, which can affect the synapses in the central nervous system of insects, having contact and stomach effects. It has strong systemic absorption in the roots of plants, can be rapidly absorbed and widely distributed in plants, and is very safe for mammals, birds, etc., and has no phytotoxicity to crops. Dinotefuran has good control effects on aphids, leafhoppers, planthoppers, etc. on various crops such as wheat, rice, vegetables, and fruit trees. Dinotefuran can be formulated into dosage forms such as granules, soluble concentrates, and wettable powders.

[0008] A suspension concentrate is also known as a water suspension concentrate, a thick suspension concentrate, or a colloidal suspension concentrate. It uses water as the dispersion medium. With the help of surfactants and other auxiliaries, through sand grinding and pulverization, the insoluble or slightly water-soluble solid technical material is evenly dispersed in water to form a coarse suspension system with fine particles, high suspension, fluidity, and uniform stability. The general processing technology of a suspension concentrate is to mix the technical material, wetting agent, dispersant, defoamer, and water for pre-dispersion and sand grinding, then add water-soluble components such as thickeners, preservatives, and antifreeze agents for homogeneous mixing, and finally filter and package.

[0009] The tea green leafhopper occurs about ten generations a year, with overlapping generations and strong reproductive ability, seriously harming tea gardens. The leaves of the affected tea plants curl, harden, the leaf margins wither, and the growth of the bud tips is slow, which has a great impact on the yield and quality of tea. Due to the large-scale and large-volume use of a single chemical pesticide all year round, the tea green leafhopper has developed high resistance to imidacloprid and pyrethroid pesticides.

[0010] Chinese Patent Application CN201310644212.9 discloses an insecticidal composition of dinotefuran and diafenthiuron, and also discloses various dosage forms including suspension concentrates and their preparation methods. However, this application only lists the types and content ranges of auxiliaries used in various dosage forms, without specifically disclosing the formulations of any dosage forms. No specific formulations and related quality indicators of any dosage forms are given in the examples, and there are no field control efficacy data for the suspension concentrate of dinotefuran and diafenthiuron.

[0011] Therefore, there is still a need to develop a pesticide preparation product of dinotefuran and diafenthiuron to meet the control needs of Empoasca vitis. Summary of the Invention

[0012] The present invention provides an insecticidal suspension concentrate composition of dinotefuran and diafenthiuron, which contains the following components in mass percentage: Diafenthiuron 30 - 40%, dinotefuran 3 - 7%, dispersant 3 - 5%, emulsifier 4 - 8%, synergist 8 - 12%, antifreeze 4 - 8%, defoamer 0.1 - 0.5%, thickening and stabilizing agent 0.1 - 0.2%, and water to make up 100%.

[0013] Preferably, the ratio of diafenthiuron to dinotefuran is 7:1.

[0014] Preferably, the dispersant is one or more of polycarboxylic acid, alkylphenol polyoxyethylene ether methyl ether condensate sulfate, fatty alcohol EO / PO block copolymer, sodium salt of naphthalene sulfonic acid formaldehyde condensate, and triethanolamine salt of triphenylvinylphenol polyoxyethylene ether phosphate.

[0015] Preferably, the emulsifier is one or more of calcium dodecylbenzenesulfonate, triphenylvinylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, and castor oil polyoxyethylene ether.

[0016] Preferably, the synergist is one or more of modified soybean oil, cottonseed oil, rapeseed oil, etc.

[0017] Preferably, the antifreeze is one or more of ethylene glycol, propylene glycol, and glycerol.

[0018] Preferably, the defoamer is one or more of silicone-based, polyether-based, and polyether-modified polysiloxane defoamers.

[0019] Preferably, the thickening and stabilizing agent is one or more of silica, diatomaceous earth, bentonite, and silicon dioxide.

[0020] The insecticidal suspension concentrate composition of the present invention is prepared by the following method: First, mix other components except the synergist and a part of the emulsifier for pre-dispersion, then conduct rough grinding through primary sand grinding, secondary sand grinding for mixing, and tertiary sand grinding for fine grinding. Then, add the synergist and the remaining part of the emulsifier under high shear to form the finished suspension agent, and conduct detection.

[0021] Adopting the above technical solution, the present invention has the following beneficial effects: (1) The insecticidal suspension agent composition of the present invention can be used to control various pests such as aphids, leafhoppers, planthoppers, thrips, etc., and has a special effect on controlling Empoasca vitis. Empoasca vitis has the characteristic of overlapping generations, that is, eggs, nymphs, and adults exist simultaneously. Diafenthiuron has an ovicidal effect and also has contact, stomach toxicity, systemic, and fumigation effects, while dinotefuran has extremely excellent control effects on piercing-sucking mouthpart pests and can kill adults well at a relatively low content. Therefore, after compounding, it can solve the problem of overlapping generations of the target and thus achieve high control efficacy.

[0022] (2) The production of the insecticidal suspension agent composition of the present invention adopts a three-stage grinding process, which can ensure that the original drug particles are finer, thus making it easier to reach the target body and not being blocked on the surface of pests; adding the synergist after grinding and before packaging can avoid the decomposition of the synergist, help improve the stability of the preparation, and save production costs.

[0023] (3) The present invention adds modified vegetable oil, which, as a plant-derived synergist, can greatly reduce the surface tension of the dilution solution without burning the leaves, quickly spread to the curly wrinkles of plant buds, and can also directly extend to the back of the leaves to kill pests hidden on the back of the leaves and in the corners, providing full coverage protection for plants. The hydrophilic end of the modified vegetable oil pulls the original drug, and the lipophilic end easily penetrates the wax layer on the surface of the insect body, leading the original drug to reach the target and play a role. The modified vegetable oil can also increase the adhesion time of the liquid medicine on the plant surface, delay the degradation of the original drug, increase the residual period, and reduce the number of pesticide applications.

[0024] (4) The present invention adds a high molecular polymer auxiliary agent. As a high molecular compound, it can regulate the formation of a stable interfacial film structure at the gas-liquid interface of the droplets, thereby regulating the droplet uniformity and particle size, and improving the deposition density of the droplets on the back of the target leaves in aerial spraying. By adjusting the droplet particle size during spraying, the drift boundary is shortened, pesticide loss is reduced, and utilization rate is improved. Description of the Drawings

[0025] Figure 1 It is a process flow chart for the preparation of the insecticidal suspension agent composition of the present invention Detailed Embodiments The technical solution of the present invention will be clearly and completely described below in conjunction with embodiments. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative work belong to the scope of protection of the present invention.

[0026] Example 1: 40% Diafenthiuron·Dinotefuran Suspension Concentrate The formulation of 40% Diafenthiuron·Dinotefuran Suspension Concentrate is as follows:

[0027] The preparation method is as follows: First, mix diafenthiuron, dinotefuran, polycarboxylic acid, fatty alcohol EO / PO block copolymer, triphenylvinylphenol polyoxyethylene ether phosphate triethanolamine, triphenylvinylphenol polyoxyethylene ether, glycerol, polydimethylsiloxane emulsion, silica and water for pre-dispersion, followed by primary sand grinding for rough grinding, secondary sand grinding for mixing grinding, and tertiary sand grinding for fine grinding. Then, add modified soybean oil and castor oil polyoxyethylene ether under high shear to form the finished suspension concentrate.

[0028] Comparative Example 1: Prepare the product of Comparative Example 1 according to the formulation and preparation method of Example 1, with the difference that modified soybean oil and castor oil polyoxyethylene ether are not added after the tertiary sand grinding for fine grinding and before packaging, but all components are mixed and then subjected to tertiary sand grinding.

[0029] Comparative Example 2: Prepare the product of Comparative Example 2 according to the formulation and preparation method of Example 1, with the difference that modified soybean oil is not added.

[0030] Prepare multiple batches of the products of the examples and comparative examples, and conduct quality index tests. The relevant data are shown in the following table:

[0031] *In Comparative Examples 1 and 2, the suspension rates of diafenthiuron and dinotefuran decreased slightly compared to Example 1, but both reached the relevant standards.

[0032] In Comparative Examples 1 and 2, the suspension rates of the two active ingredients decreased relative to Example 1, but not significantly; the thermal storage stabilities were both unqualified and precipitation occurred. Without being bound by any theory, the inventors believe that it may be because the modified soybean oil can increase the viscosity of the medicament to a certain extent. Under normal conditions, although most of the modified soybean oil in Comparative Example 1 decomposed after three-stage sand grinding and Comparative Example 2 did not add modified soybean oil, other auxiliaries in the preparation played a role, so that the suspension rate of the active ingredient did not decrease significantly. However, under thermal storage conditions, the movement of the particles in the suspending agent accelerated, and the probability of collision and aggregation increased. In Comparative Examples 1 and 2, the function of the modified soybean oil to increase viscosity was lost or non-existent, thus resulting in precipitation.

[0033] Example 2: Field experiment Controlling Empoasca vitis Experiment time and location: Conducted in a tea garden in Hubei in mid-June 2023 Test agents: The 40% diafenthiuron·dinotefuran suspending agent prepared in Example 1 of this application, the control agents of Comparative Examples 1 and 2, and a water control.

[0034] Experiment method: A total of 12 plots were set up, arranged in a randomized block design, with each plot having an area of 20m 2 , and Example 1, Comparative Examples 1 and 2, and the water control were each repeated 3 times. 50g of the agent per mu was mixed with 50kg of water, and a knapsack sprayer was used to evenly spray to the tips of the leaves until water droplets formed on the middle, upper, and side parts of the tea trees. No other agents were applied to control pests and diseases during the experiment.

[0035] Investigation method: Before applying the medicine, the initial insect population of each experimental treatment and control treatment was investigated. The insect population of each experimental treatment and control treatment was investigated 3 days and 7 days after applying the medicine. 20 mature leaves were randomly investigated on both sides of each row of tea trees to count the insect population of Empoasca vitis Pharmacodynamic calculation method:

[0036] Experimental results:

[0037] From the above experimental data, it can be seen that the sample of Example 1 of this application has good control efficacy against Empoasca vitis, reaching over 85% 3 days after applying the medicine, and the control efficacy can still be maintained without decrease, or even increased, 7 days after applying the medicine; although Comparative Example 1 added modified soybean oil, due to the grinding process, most of the modified soybean oil decomposed, and the control efficacy was average, only 77%, and the control efficacy decreased significantly 7 days after applying the medicine; Comparative Example 2 did not add modified soybean oil, the control efficacy was less than 70%, and decreased to less than 60% 7 days after applying the medicine.

[0038] It can be seen that the medicament of the present invention has excellent control efficacy against Empoasca vitis, and has a long-lasting effect, and can maintain the control efficacy for at least 7 days after application without reduction. Without being bound by any theory, the inventor believes that the modified soybean oil added in the suspension concentrate of the present invention can reduce the surface tension of the liquid medicine, enable the liquid medicine to spread rapidly on the leaves, and can also make the liquid medicine more easily penetrate the wax layer on the surface of the insect body to exert the drug effect, and can improve the adhesion time of the liquid medicine on the plant surface, delay the degradation of the technical material, and extend the long-lasting effect period.

[0039] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An insecticidal suspension composition, characterized in that: In terms of mass percentage, it contains the following components: Butafenthiuron 30-40%, dinotefuran 3-7%, dispersant 3-5%, emulsifier 4-8%, synergist 8-12%, antifreeze 4-8%, defoamer 0.1-0.5%, thickening stabilizer 0.1-0.2%, water to make up 100%.

2. The insecticidal suspension composition according to claim 1, characterized in that The ratio of diafenthiuron to dinotefuran is 7:

1.

3. The insecticidal suspension composition according to claim 1, characterized in that The dispersant is one or more of polycarboxylic acid, alkylphenol polyoxyethylene ether methyl ether condensate sulfate, fatty alcohol EO / PO block copolymer, naphthalenesulfonic acid formaldehyde condensate sodium salt, tristyrylphenol polyoxyethylene ether phosphate triethanolamine.

4. The insecticidal suspension composition according to claim 1, characterized in that The emulsifier is one or more of calcium dodecylbenzene sulfonate, tristyrylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, and castor oil polyoxyethylene ether.

5. The insecticidal suspension composition according to claim 1, characterized in that The synergist is one or more of modified soybean oil, cottonseed oil, rapeseed oil and the like.

6. The insecticidal suspension composition according to claim 1, characterized in that The antifreeze agent is one or more of ethylene glycol, propylene glycol, and glycerol; the defoaming agent is one or more of silicone, polyether, and polyether-modified polysiloxane defoaming agents; and the thickening stabilizer is one or more of white carbon black, diatomaceous earth, bentonite, and silicon dioxide.

7. The method for preparing the insecticidal suspension composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: First, the other ingredients except the synergist and a part of the emulsifier are mixed and pre-dispersed, and then the synergist and the remaining part of the emulsifier are added under high shear to form a suspension product, which is then tested.

8. Use of the insecticidal suspension composition according to any one of claims 1 to 6 or the insecticidal suspension composition prepared by the preparation method of claim 7 in controlling crop pests.

9. The use of the insecticidal suspension according to claim 8, characterized in that: The crop pests include aphids, leafhoppers, plant hoppers, and thrips.

10. The use of the insecticidal suspension according to claim 9, characterized in that: The crop pest is the tea green leafhopper.

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