Composition with long-acting red repairing effect and application of composition in cosmetics
Through the composition of lime fruit extract, grapefruit fruit extract and traclutin, the problem of difficult maintenance of the treatment effect of capillary dilation in the prior art is solved, and the significant red-refining effect and anti-sting properties are achieved, and the treatment effect is extended.
Patent Information
- Application Number
- CN202510164679.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-14
- Publication Date
- 2025-05-30
AI Technical Summary
In the treatment of capillary dilation, the prior art rapidly blocks the hyperplastic capillaries but fails to effectively repair the damaged barrier and capillaries, making the treatment effect difficult to maintain and the red repair effect is not good.
A specific combination of lime fruit extract, grapefruit fruit extract and traclutin is used to form a composition with long-acting red-refining effect, which enhances the inhibitory effect of skin heme through synergistic effects.
Significantly improve the skin's heme level, improve the skin's anti-lactic acid tingling properties, prolong the treatment effect, and avoid the recurring attack of capillary dysplasia.
Smart Images
Figure CN120053336A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of cosmetics, and in particular to a composition with long-lasting redness-removing effect and application thereof in cosmetics. Background Art
[0002] Facial telangiectasia is one of the common skin diseases. Patients usually have a high degree of skin sensitivity and are easily stimulated by the external environment, resulting in symptoms such as redness, itching, and fever, which seriously affects the beauty of the skin and causes discomfort to patients. At present, clinical treatment mainly includes two treatment options: using moisturizing and other functional repair dressings to assist in improving barrier function and laser blocking of dilated capillaries. Repair dressings have a certain repair effect on barrier damage caused by lack of care or environmental factors, but their treatment is slow and has little effect on more severe telangiectasia. Laser is currently the fastest and most effective means of treating telangiectasia. Dilated capillaries are generally cured or significantly improved after several laser treatments, but if the skin barrier function or damaged blood vessels are not effectively repaired, the treated area will relapse, thus affecting the maintenance of the efficacy. Therefore, repairing the damaged barrier and capillaries while quickly blocking the proliferating capillaries is of great clinical significance for curing telangiectasia and avoiding its recurrence. Summary of the invention
[0003] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a composition with long-lasting redness-reducing effect and its application in cosmetics.
[0004] To achieve the above object, the technical solution adopted by the present invention is:
[0005] In a first aspect, the present invention provides a composition comprising the following components in parts by weight: 60 to 70 parts of sour orange fruit extract, 2.5 to 3.5 parts of grapefruit fruit extract and 2 to 3 parts of troxerutin.
[0006] The invention selects and matches sour orange fruit extract, grapefruit fruit extract and troxerutin, and the obtained composition has the effect of synergistic and long-lasting redness repairing.
[0007] As a preferred embodiment of the composition of the present invention, in the composition, the weight ratio of the sour orange fruit extract to the grapefruit fruit extract is: sour orange fruit extract:grapefruit fruit extract=(16-26):1.
[0008] Furthermore, the ratio of the total weight of the sour orange fruit extract and the grapefruit fruit extract to the weight of troxerutin is: (sour orange fruit extract+grapefruit fruit extract):troxerutin=68:2.5.
[0009] Most preferably, the composition comprises the following components in parts by weight: 65 parts of lime fruit extract, 3 parts of grapefruit fruit extract, and 2.5 parts of troxerutin; at this time, the weight ratio of lime fruit extract to grapefruit fruit extract is 21.7:1. When the components of the present invention are formulated with the above-defined optimal dosage ratio, the prepared composition has the best control effect on skin heme, thus exerting an excellent redness-reducing effect and at the same time improving the anti-lactic acid stinging property of the skin.
[0010] In a second aspect, the present invention provides the use of the composition as described above in the preparation of a product for preventing and / or treating telangiectasia of the skin.
[0011] In a third aspect, the present invention provides the use of the composition as described above in the preparation of a product for anti-skin sensitivity.
[0012] In a fourth aspect, the present invention provides a cosmetic, which contains the composition as described above.
[0013] Further, the mass percentage content of the composition in the cosmetic is 0.5-5%.
[0014] Further, the mass percentage content of the composition in the cosmetic is 1%.
[0015] Further, the cosmetic further contains cosmetically acceptable excipients.
[0016] Further, the excipients include at least one of disodium EDTA, glycerol, propylene glycol, hyaluronic acid, 1,2-hexanediol, and water.
[0017] Further, the cosmetic includes leave-on cosmetics and rinse-off cosmetics.
[0018] Compared with the prior art, the beneficial effects of the present invention are as follows:
[0019] By combining lime fruit extract, grapefruit fruit extract, and troxerutin in a specific manner, the present invention obtains a raw material composition with a remarkable redness-reducing effect; in this composition, lime fruit extract, grapefruit fruit extract, and troxerutin act on different targets to synergistically enhance the inhibitory effect on skin heme. In addition, the selection of the composition of the present invention is specific, and replacing the types in the composition will lead to a significant reduction in the redness-reducing effect. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] Figure 1 It is a skin test photo of a subject using the test product of Example 1. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0021] To better illustrate the objectives, technical solutions, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. Other materials, reagents, etc. used in the embodiments can be obtained from commercial sources unless otherwise specified.
[0022] The main component of the bitter orange fruit extract is flavonoid, and the mass percentage of flavonoid ≥ 95%. It can be obtained through regular purchase or prepared by existing preparation methods. Specifically, it can be purchased from Shanxi Ruisi Biotechnology Co., Ltd., Shaanxi Wanhe Pharmaceutical Co., Ltd., or Shaanxi Xinkang Biotechnology Co., Ltd.
[0023] The main component of the grapefruit fruit extract is naringin, and the mass percentage of naringin ≥ 95%. It can be obtained through regular purchase or prepared by existing preparation methods. Specifically, it can be purchased from Shanxi Ruisi Biotechnology Co., Ltd., Shaanxi Yuanshengte Biotechnology Co., Ltd., or Shaanxi Shizhen Baicao Biotechnology Co., Ltd.
[0024] Troxerutin can be obtained through regular purchase or prepared by existing preparation methods. Specifically, it can be purchased from Shaanxi Qianhui Biotechnology Co., Ltd., Shaanxi Hongyi Kaiyuan Biotechnology Co., Ltd., or Baoji Fangsheng Biological Development Co., Ltd.
[0025] The tea tree flower extract was purchased from Shaanxi Ruilin Panier Biotechnology Co., Ltd.
[0026] The red pomegranate extract was purchased from Xi'an Yuze Biotechnology Co., Ltd.
[0027] The main component of the bletilla striata extract is bletilla striata polysaccharide, and the mass percentage of bletilla striata polysaccharide ≥ 80%. It can be obtained through regular purchase or prepared by existing preparation methods. It is produced by Xi'an LvTian Biotechnology Co., Ltd. and can be prepared with reference to Examples 1 to 4 of Patent 2021106056918.
[0028] Examples 1 - 6
[0029] The composition components of the compositions of Examples 1 - 6 are shown in Table 1.
[0030] Table 1 Formulation table of the compositions of Examples 1 - 6 (parts by weight)
[0031]
[0032] Comparative Examples 1 - 16
[0033] The composition components of the compositions of Comparative Examples 1 - 13 are shown in Table 2.
[0034] Table 2 Formulation table of the compositions of Comparative Examples 1 - 13 (parts by weight)
[0035]
[0036]
[0037] In Table 2, "-" indicates no addition.
[0038] Comparative Example 14
[0039] This comparative example provides a composition with the effect of reducing skin redness. The difference from Example 1 is that the extract of tea tree flower is used instead of the extract of lime fruit, and the other components and their contents remain unchanged.
[0040] Comparative Example 15
[0041] This comparative example provides a composition with the effect of reducing skin redness. The difference from Example 1 is that the extract of red pomegranate is used instead of the extract of grapefruit fruit, and the other components and their contents remain unchanged.
[0042] Comparative Example 16
[0043] This comparative example provides a composition with the effect of reducing skin redness. The difference from Example 1 is that the extract of bletilla striata is used instead of troxerutin, and the other components and their contents remain unchanged.
[0044] Effect Example 1
[0045] Test method: The compositions of the examples and comparative examples were formulated into test products [composition 1% (w / v), disodium EDTA 0.03% (w / v), glycerol 4% (v / v), propylene glycol 2% (v / v), hyaluronic acid 0.03% (w / v), 1,2 - hexanediol 0.5% (v / v) and water, with water making up the balance]. Before the subjects used the test products, a heat source model was made on the face using an infrared therapeutic instrument. After the face showed obvious redness, the test products were used. The skin hemoglobin of the left and right cheeks of the subjects was measured at D0 / T0 (before modeling), D0 / T1 immediately (after modeling) before using the test products, at T5min (5 minutes after using the test products), at T10min (10 minutes after using the test products), and at T15min (15 minutes after using the test products); the skin hemoglobin of the right cheek was measured at D28 / T0 (before modeling) and D28 / T1 immediately (after modeling) 28 days after using the test products; the facial skin lactic acid stinging scores of the subjects were measured at D0 (before using the test products) and D28 (28 days after using the test products); at the same time, a self - evaluation questionnaire was conducted on the subjects at T15min (15 minutes after using the test products) and D28 (28 days after using the test products). The test results before and after product use were compared by statistical test methods to determine whether there were statistical differences.
[0046] Table 3 Test Information Table
[0047]
[0048] Table 4 Results of the improvement rate of skin heme and the improvement rate of lactic acid stinging in the redness correction test
[0049]
[0050]
[0051] Table 4 results showed that the skin heme value increased immediately at T1 after the skin of the test sample area of the subjects was modeled with a heat source, and there were significant differences compared with T0 (before modeling) (P<0.001), indicating that the modeling was successful after the skin was irradiated with the infrared therapeutic instrument; the improvement rates of the reduction of skin heme in the subjects using the sample of Example 1 at 5 min, 10 min, and 15 min after application were 7.47%, 12.09%, and 16.83% respectively. The skin heme of the subjects continuously using the sample of Example 1 for 28 days showed a significant decrease compared with the baseline value (P<0.001), and the improvement rate was 6.71%. There was a significant decrease compared with that after modeling on the 0th day after 28 days of modeling (P<0.001), and the improvement rate was 8.19%.
[0052] The improvement rate of D28 / T0-D0 / T0 skin heme of the test products prepared in Examples 1 to 7 all reached more than 6%, showing a significant effect of redness correction. Among them, the improvement rate of D28 / T0-D0 / T0 skin heme of the test product prepared by the technical solution of Example 1 reached 6.71%, and the redness correction effect was the best. The skin test photos of the subjects using the test product of Example 1 are as Figure 1 shown.
[0053] After using the composition of Example for 28 days, the lactic acid stinging scores of the subjects showed a significant decrease compared with the baseline value after 28 days of product use (P<0.001), and the improvement rates were all above 25%.
[0054] When any one or two of the three components of lime fruit extract, grapefruit fruit extract and troxerutin are missing in Comparative Examples 1-9, the improvement effect of the prepared component on skin heme is significantly reduced. When the total weight ratio of lime fruit extract and grapefruit fruit extract to the weight of troxerutin is 68:2.5, the improvement rate of skin heme of the prepared composition is relatively good; under this component ratio, in Comparative Examples 10 and 11, the lime fruit extract or grapefruit fruit extract is missing respectively, and the better improvement rate of skin heme cannot be achieved; under this component ratio, in Comparative Examples 12 and 13, if the proportion of lime fruit extract is further reduced or increased, the improvement rate of skin heme is also further reduced. In addition, when the lime fruit extract, grapefruit fruit extract and troxerutin are replaced with other extracts with redness-reducing effects in Comparative Examples 14-16, the improvement rate of skin heme of the prepared composition is also significantly reduced compared with that of the Examples. When the effective substance concentrations of Comparative Examples 4-6 are added up according to the ratio of Example 1 respectively, the same efficacy result as that of Example 1 cannot be obtained, and the efficacy is lower than that of Example 1. The efficacy results of Comparative Examples 7-9 added up cannot reach the efficacy result of Example 1. The above results all show that there is an obvious synergistic effect among the specific components selected in the present invention, especially between lime fruit extract, grapefruit fruit extract and troxerutin. The three cooperate with each other and influence each other, and can significantly improve the efficacy of the product in improving skin heme, and none of the components can be missing.
[0055] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present invention.
Claims
1. A composition, characterized in that The invention comprises the following components in parts by weight: 60-70 parts of sour orange fruit extract, 2.5-3.5 parts of grapefruit fruit extract and 2-3 parts of troxerutin.
2. The composition according to claim 1, characterized in that The weight ratio of the sour orange fruit extract to the grapefruit fruit extract is: sour orange fruit extract:grapefruit fruit extract=(16-26):
1.
3. The composition according to claim 2, characterized in that The ratio of the total weight of the sour orange fruit extract and the grapefruit fruit extract to the weight of troxerutin is: (sour orange fruit extract+grapefruit fruit extract):troxerutin=68:2.
5.
4. The composition according to claim 3, characterized in that The invention comprises the following components in parts by weight: 65 parts of sour orange fruit extract, 3 parts of grapefruit fruit extract and 2.5 parts of troxerutin.
5. Use of the composition according to any one of claims 1 to 4 in the preparation of a product for preventing and / or treating skin telangiectasia.
6. Use of the composition according to any one of claims 1 to 4 in the preparation of products to prevent skin sensitivity.
7. A cosmetic, characterized in that: The cosmetic contains the composition according to any one of claims 1 to 4.
8. The cosmetic according to claim 7, characterized in that The mass percentage of the composition in cosmetics is 0.5-5%.
9. The cosmetic according to claim 7 or 8, characterized in that: The cosmetic also contains cosmetically acceptable auxiliary materials.
10. The cosmetic according to claim 9, characterized in that: The auxiliary material comprises at least one of EDTA disodium salt, glycerol, propylene glycol, hyaluronic acid, 1,2-hexanediol and water.