Preparation and processing method of drug containing gene recombinant antioxidant enzyme

Abstract

The invention provides a preparation and processing method of a drug containing gene recombinant antioxidant enzyme, and relates to the technical field of enzyme product preparation and processing, and the method comprises the following steps: S1, collecting raw materials of each component: firstly, collecting the raw materials of each component for preparing the drug containing gene recombinant antioxidant enzyme; various raw materials including glucan, fructo-oligosaccharide, galactooligosaccharide, superoxide dismutase, vitamin C, bunge cherry seed powder, cassia seed powder, turmeric, sorbitol, hydroxypropyl methyl cellulose, silicon dioxide and magnesium stearate are collected and separated from animals and plants or purchased from the market. The manufacturing and processing method of the medicine containing the gene recombination antioxidant enzyme is high in production efficiency, high in packaging speed, free of manual operation in the whole process, high in automation degree and capable of automatically separating packaging bags. By means of the manufacturing and processing method of the medicine containing the gene recombination antioxidant enzyme, pill particles can be efficiently sealed through film bags.

Description

Technical Field

[0001] The present invention relates to the technical field of enzyme product manufacturing and processing, and specifically to a manufacturing and processing method of a drug containing genetically recombinant antioxidant enzymes. Background Art

[0002] Inflammatory bowel disease is a chronic granulomatous disease of the gastrointestinal tract with unknown causes, mostly seen in the terminal ileum and adjacent colon. The lesions are segmental or skip-shaped and are transmural intestinal wall inflammation. Ulcerative colitis, also known as non-specific ulcerative colitis, is a chronic inflammatory disease of the rectum and colon with unknown causes. The lesions mainly involve the large intestine mucosa and submucosa. The rectum and distal colon are the most common affected sites, but when the lesions are severe, the entire colon and terminal ileum can also be involved. Their manifestations are generally diarrhea, abdominal pain, and even bloody stools in some people. It is currently believed that the pathogenesis of inflammatory bowel disease may be as follows: certain genetic determinants make susceptible individuals prone to the disease. Under the action of infectious agents or antigens in the intestinal lumen, the mucosal-associated lymphoid tissue is stimulated, causing an upregulated T cell response, thereby activating a network of various cytokines, causing local tissue inflammation, which is continuously amplified and sustained, resulting in damage to the intestinal wall and corresponding clinical manifestations. Treatments often use glucocorticosteroid (GCS) drugs (prednisone, adrenal cortical hormones) and antibiotics, etc.

[0003] Currently, our company has also publicly disclosed relevant patented technologies for the preparation method of drugs containing antioxidant enzyme compositions. For example, Patent No. CN202110269039.3 discloses a preparation method of a drug containing highly stable novel antioxidant enzymes for treating inflammatory enteritis. The preparation steps of the drug containing highly stable novel antioxidant enzymes for treating inflammatory enteritis are as follows: Step 1: Put dextran, fructooligosaccharide, and galactooligosaccharide into a homogenizer for homogenization; Step 2: Add superoxide dismutase, vitamin C, Prunus japonica powder, Cassia obtusifolia powder, turmeric, sorbitol, hydroxypropyl methylcellulose, silicon dioxide, and magnesium stearate to the homogenized material and then crush it; Step 3: Sieve the crushed material through a 60-mesh sieve; Step 4: Add 1%-4% water to the filtered material and stir; Step 5: Press and form tablets in an environment with a temperature of 10-30°C and a humidity of 40%RH-55%RH. In this application document, the occurrence of local inflammation caused by cell reactions activating various cytokine reactions is reduced, and the damage to the intestinal wall is reduced.

[0004] Although the above patent discloses the relevant preparation method of drugs containing antioxidant enzyme compositions, relevant hardware support still needs to be considered during the actual implementation process of the preparation method of drugs containing antioxidant enzyme compositions. Moreover, the existing preparation methods of drugs containing antioxidant enzyme compositions still have some deficiencies. The specific deficiencies are as follows: During the production and processing of pill particles, it is necessary to store the pill particles in a sealed package. Currently, the packaging and storage of pill particles mainly use bottled sealing. Bottled sealing is costly and has a slow packaging speed, making it difficult to meet the needs of enterprises for batch production and processing of pill particles. Therefore, a manufacturing and processing method for drugs containing recombinant antioxidant enzymes is needed. Summary of the Invention

[0005] Aiming at the problems in the prior art, the purpose of the present invention is to provide a manufacturing and processing method for drugs containing recombinant antioxidant enzymes, and solve the problems described in the above background technology: During the production and processing of pill particles, it is necessary to store the pill particles in a sealed package. Currently, the packaging and storage of pill particles mainly use bottled sealing. Bottled sealing is costly and has a slow packaging speed, making it difficult to meet the technical problems of enterprises for batch production and processing of pill particles.

[0006] The technical problems to be solved by the present invention are achieved by the following technical solutions: A manufacturing and processing method for drugs containing recombinant antioxidant enzymes includes the following steps: S1. Collect raw materials of each component: First, collect raw materials of each component for preparing drugs containing recombinant antioxidant enzymes, and separate and prepare various raw materials such as dextran, fructooligosaccharide, galactooligosaccharide, superoxide dismutase, vitamin C, Prunus japonica powder, Cassia obtusifolia powder, turmeric, sorbitol, hydroxypropyl methylcellulose, silicon dioxide, and magnesium stearate by collecting and separating from animals and plants or purchasing from the market. S2. Synchronous production and processing on multiple production lines: Set up multiple factory workshops or multiple production lines in the same workshop. Each production line independently processes and manufactures the various raw materials collected in step S1, and respectively prepares and grinds the various raw materials collected in step S1 into fine particles to obtain powdery substances of different raw materials in granular form. S3. Big bag packaging: Quantitatively fill the granular powder obtained in step S2 into an easily sealable polyethylene bag and seal it. During the sealing process, first evacuate the air and then seal. The granular powder filled into the polyethylene bag is controlled to be 25KG per bag in packaging weight, and the error range for filling into the bag is plus or minus not exceeding 500G; each component of granular powder keeps the inside of the packaging bag dry and clean during the bagging process. S4. Storage and stacking: Seal and store the granular powder packed in bags in step S3 through polyethylene bags, and stack the neatly packaged granular powder of each component around the corresponding production line or in the factory workshop where production is carried out, waiting for the next transfer. S5. Material sorting and statistics: Set up a general pharmaceutical production workshop that meets pharmaceutical production standards. Transfer the granular powders of different material properties separately stacked around the corresponding production lines or in different factory workshops during step S4 to the pharmaceutical production workshop through polyethylene bags for logistics transportation. In the pharmaceutical production workshop, count, sort, and analyze the granular powders of each component for preparing the antioxidant enzyme composition. S6. Uniform mixing: First, put the dextran powder, fructooligosaccharide powder, and galactooligosaccharide powder in the pharmaceutical production workshop into a homogenizer for homogenization. Then, add superoxide dismutase powder, vitamin C powder, Prunus japonica powder, Cassia seed powder, turmeric powder, sorbitol powder, hydroxypropyl methylcellulose powder, silicon dioxide powder, and magnesium stearate powder to the homogenized materials for homogenization treatment with water injection and stirring. Stir evenly by adding 3%-5% water according to the total weight after homogenization. S7. Pill pressing and forming: Press and form pills in an environment with a temperature of 10-30°C and a humidity of 40%RH-55%RH to obtain pill-shaped antioxidant enzyme composition. S8. Pill transfer: Transfer the pills obtained by pill pressing and forming to the pill hopper. S9. Pretreatment of the thin film bag: A vertical clamping and sealing mechanism and a double-sided locking and sealing mechanism are set at the bottom of the pill hopper. The vertical clamping and sealing mechanism first heat-seals the polyethylene film formed into a circular tube, and the double-sided locking and sealing mechanism heat-seals the bottom of the polyethylene film that has formed a circular tube. S10. Pill filling: The pills transferred to the pill hopper pass through the spraying tube at the bottom of the pill hopper and extend through the wrapping and shaping tube to the bottom of the wrapping and shaping tube. The pills in the pill hopper are quantitatively ejected downward through the bottom of the spraying tube extending from the bottom of the wrapping and shaping tube and fall into the circular polyethylene film for packaging. S11. Dry powder sealing: The polyethylene film containing pills in step S10 falls downward by gravity into the double-sided locking and sealing mechanism. The double-sided locking and sealing mechanism heat-seals the top and bottom of the polyethylene film containing pills, and automatically cuts off at the middle position between the two heat-sealing lines to obtain small bag-packed recombinant antioxidant enzyme drug particles. S12. Collection and packing: The small bagged particles obtained in step S11 fall into the collection box by gravity. The collection box is used to collect the obtained small bagged particles for later centralized packing.

[0007] As a preferred technical solution of the present invention, the manufacturing and processing method described in steps S8 to S12 is mainly completed by a medicine pellet packaging machine, which includes a bottom support plate fixed to the ground, a vertical machine box upright on the top of the bottom support plate is fixed on the top of the bottom support plate, a packaging bag winding drum is arranged on the top of the vertical machine box, and a polyethylene film is wound on the surface of the packaging bag winding drum; the medicine pellet hopper is arranged above the packaging bag winding drum, a vertical particle spraying pipe is arranged at the bottom of the medicine pellet hopper, a wrapping molding pipe is arranged on the outer wall of the particle spraying pipe, an outer film guide plate is arranged in front of the wrapping molding pipe, an inner film guide plate is arranged behind the wrapping molding pipe, and film guide pressing wheels are arranged on the surface of the inner film guide plate and the surface of the outer film guide plate; The wrapping and molding tube is a hollow flat tube with a flat rear end and an arc-shaped front end. The wrapping and molding tube is fixed to the front end surface of the vertical chassis through a bracket, and the particle spraying tube at the bottom of the medicine particle hopper passes through the middle of the wrapping and molding tube and extends to the bottom of the wrapping and molding tube.

[0008] The polyethylene film wound on the packaging bag winding drum is guided by the outer film guide plate and the inner film guide plate so that the polyethylene film is wrapped on the outer wall of the wrapping molding tube, a vertical clamping and sealing mechanism is arranged in the middle of the outer wall of the wrapping molding tube, the vertical clamping and sealing mechanism is arranged at the bottom of the outer film guide plate, a bag separation and lifting mechanism is arranged below the vertical clamping and sealing mechanism, a double-sided locking and sealing mechanism is arranged at the bottom of the double-sided locking and sealing mechanism, a force-releasing support plate is arranged at the bottom of the force-releasing support plate, and a collection box is arranged at the bottom of the force-releasing support plate.

[0009] As a preferred technical solution of the present invention, the bilateral locking mechanism includes a fixed frame 2 fixed to the front end face of the vertical chassis, and round rod linear guides are symmetrically arranged on the left and right sides of the front end face of the fixed frame 2, and rear hot melt support plates are fixedly installed on the top ends of the round rod linear guides on both sides, and the bottom of the polyethylene film wrapped around the bottom of the outer wall of the particle injection tube extends into the middle of the round rod linear guides on both sides, and the surface of the fixed frame 2 is provided with reciprocating horizontally sliding heat sealing strips 2, and there are two heat sealing strips 2 in total, and a cutting knife is arranged in the middle position of the two heat sealing strips 2, and the surface of the rear hot melt support plate is provided with a makeshift hot melt groove cooperating with the two heat sealing strips 2, and a cutting knife is arranged in the middle position of the two makeshift hot melt grooves.

[0010] As a preferred technical solution of the present invention, a linear push rod motor three is fixedly installed on the rear end face of the vertical chassis. The linear push rod motor three passes through the vertical chassis and extends a push rod towards the middle of the front end of the fixed frame two. The top end of the push rod of the linear push rod motor three is provided with a sliding support plate, the sliding support plate is parallel to the front end face of the vertical chassis, and an inclined liquid pressing cloth pushing plate is arranged on the front end face of the sliding support plate. The liquid pressing cloth pushing plate is flat, the bottom of the inclined liquid pressing cloth pushing plate inclines forward, and the bottom of the liquid pressing cloth pushing plate has a function of elastically retracting backward.

[0011] As a preferred technical solution of the present invention, a cloth pushing roller is arranged at each end of the inner circle of the liquid pressing cloth pushing plate. A roller support is arranged between the two cloth pushing rollers, and the cloth pushing rollers can freely rotate at both ends of the roller support. A movable support is rotatably connected to the left and right ends of the cloth pushing roller near the top end of the liquid pressing cloth pushing plate. A sliding block is arranged at the top end of each movable support. A sliding frame is arranged on the front end face of the sliding support plate near the top end face of the sliding support plate. The sliding block is slidably connected to the surface of the sliding frame, and the sliding block can reciprocally slide up and down on the surface of the sliding frame.

[0012] As a preferred technical solution of the present invention, a sliding shaft rod is rotatably connected to the left and right ends of the cloth pushing roller near the bottom end of the liquid pressing cloth pushing plate. Two through circular holes are formed on the surface of the sliding support plate near the bottom end face of the sliding support plate. Each sliding shaft rod is slidably connected to the circular hole on the surface of the sliding support plate, and a compression spring is arranged in the middle of the surface of each sliding shaft rod.

[0013] As a preferred technical solution of the present invention, the vertical clamping and sealing mechanism includes a clamping strip support frame fixed on the top end of the vertical chassis. Gear transmission support plates are symmetrically arranged on the left and right sides of the front end of the clamping strip support frame. Electric supports three are fixed at the top ends of the two gear transmission support plates. The polyethylene film wrapped on the outer wall of the wrapping and shaping tube extends downward from the middle of the two gear transmission support plates. A heat-sealing plastic clamping strip two and a heat-sealing plastic clamping strip one are arranged on the inner wall surface of one of the gear transmission support plates. A V-shaped hot melting groove is formed on the surface of the heat-sealing plastic clamping strip one. A heat-sealing pressing strip one is arranged on the surface of the heat-sealing plastic clamping strip two. The surface of the heat-sealing pressing strip one is provided with a contour matching the surface of the V-shaped hot melting groove.

[0014] As a preferred technical solution of the present invention, the bag separating and lifting mechanism includes a free bracket arranged on the front face of the vertical chassis. The free bracket is arranged to reciprocally slide and lift on the front face of the vertical chassis. Symmetrically fixed on the left and right sides at the front end of the free bracket are side linear guides. Fixed at the top ends of the two side linear guides is a disc bracket. The polyethylene film wrapped around the outer wall of the spraying particle tube extends downward from the middle parts of the two free brackets on both sides. Slidingly connected to the middle parts of the two side linear guides is a sliding support plate. On the surface of the sliding support plate are provided two silica gel discs I. On the surface of the disc bracket are provided two silica gel discs II corresponding to the silica gel discs I.

[0015] As a preferred technical solution of the present invention, the force unloading support piece is a metal elastic piece with a vertical top and an arc-shaped bent bottom. The surface of the force unloading support piece is a smooth arc surface.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: 2. The manufacturing and processing method of the drug containing genetically recombinant antioxidant enzyme provided by the present invention has high production efficiency, fast packaging speed, does not require manual operation throughout the process, has a high degree of automation, and automatically separates packaging bags. The manufacturing and processing method of the drug containing genetically recombinant antioxidant enzyme can efficiently seal the film bags for pill particles. In the initial state, the middle part of the tubular polyethylene film is pre-heat sealed by the vertical clamping and sealing mechanism, and the bottom of the polyethylene film is heat sealed in cooperation with the bilateral locking and sealing mechanism. Then, a quantitative amount of pill particles is ejected from the bottom of the spraying particle tube. The quantitative amount of pill particles is contained in the polyethylene film heat sealed on the left side and at the bottom. Since the vertical clamping and sealing mechanism is arranged above the bottom of the spraying particle tube, the height of the heat seal on the left side of the packaging film is higher than the bottom of the spraying particle tube, which can effectively prevent the quantitative pill particles ejected from the spraying particle tube from spilling out. At this time, the bag separating and lifting mechanism clamps the packaging film containing the quantitative pill particles and moves it downward to a predetermined height. The bilateral locking and sealing mechanism below clamps each other through the sliding support plate and the rear heat sealing support plate, and heat seals the polyethylene film extending into the bilateral locking and sealing mechanism at two places. The two heat seals form two parallel heat-sealed plastic lines, and a quick shearing is performed at the adhesion position between the two parallel heat-sealed plastic lines, so that the adjacent two polyethylene films are cut off and separated, improving the production, processing and packaging efficiency of the pill particles.

[0017] 3. The heat-melting groove of the present invention is a groove of V-shaped structure, and the inner wall of the heat-melting groove is heated to a temperature capable of heat-melting the polyethylene film by metal tungsten wire, and the temperature is kept constant. The two surfaces of the heat-sealing strip are provided with a profile matching the heat-melting groove, so that the heat-melting plastic sealing area of ​​the polyethylene film can be increased during the hot-melting process, the fastness of the heat-melting plastic sealing is improved, the tightness of the sealing is improved, the closeness of the edge of the packaging bag is increased, it is not easy to debond, the sealing safety is high and the sealing speed is fast, and the heat-melting plastic sealing groove of the V-shaped structure can quickly heat-melt the packaging film, and the heat-melt plastic sealing efficiency is high. The double-sided locking mechanism can quickly cut the adhesion position of the two heat-melt plastic sealing lines after the heat-melting plastic sealing is completed, so that the two adjacent polyethylene films 5 are cut off and separated, thereby improving the production and processing efficiency of the pill particles.

[0018] 4. For the polyethylene film that moves downward into the double-sided locking and sealing mechanism, the present invention pushes the sliding support plate to move toward the rear hot-melt support plate through the linear push rod motor 3, and the surface of the pressure liquid push cloth gradually fits upward from the bottom to the surface of the rear hot-melt support plate. Since the pressure liquid push cloth is inclined, it pushes the quantitative pill particles in the packaging film upward to achieve a lifting action, and moves the quantitative pill particles in the packaging film away from the hot-melt plastic sealing area, so that the heat-sealing pressure strip 2 under the sliding support plate and the giving way hot melt groove are hot-melted, which can effectively reduce the influence of the pill particles on the hot-melt plastic sealing area, thereby significantly reducing the phenomenon of loose hot-melt plastic sealing and incomplete sealing, and can effectively improve the production yield of pill particles.

[0019] 5. The yielding hot melt groove of the present invention is a groove of V-shaped structure, and the inner wall of the yielding hot melt groove is heated to a temperature capable of hot-melting the polyethylene film by metal tungsten wire, and maintained at a constant temperature. The heat-sealing pressure strip 2 can increase the hot-melt plastic sealing area of ​​the polyethylene film in the process of extruding the polyethylene film into the yielding hot melt groove for hot melting, improve the tightness of the hot-melt plastic sealing, increase the closeness of the edge of the packaging bag, and is not easy to debond, has high sealing safety and fast sealing speed. The yielding hot melt groove of V-shaped structure can quickly hot-melt plastic seal the packaging film, and the hot-melt plastic sealing efficiency is high. Through the double-sided locking mechanism, the adhesion position of the two hot-melt plastic sealing lines can be quickly cut off after the hot-melt plastic sealing is completed, so that the two adjacent polyethylene films are cut off and separated, thereby improving the production and processing efficiency of the pill particles. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0021] Figure 1 The present invention is a flowchart of the steps of the method for preparing and processing a drug containing a genetically recombinant antioxidant enzyme; Figure 2 The left side structural schematic diagram of the method for preparing and processing the gene-recombinant antioxidant enzyme drug of the present invention; Figure 3 is the partial enlarged view of part A in the attached drawings of the present invention; Figure 2 Figure 4 is the partial enlarged view of part B in the attached drawings of the present invention; Figure 3 Figure 5 is the partial top view structural schematic diagram of the double-sided locking mechanism of the present invention; Figure 6 is the rear view structural schematic diagram of the manufacturing and processing method of the drug containing genetically recombinant antioxidant enzyme of the present invention; Figure 7 is the partial top view structural schematic diagram of the bag-splitting and lifting mechanism of the present invention; Figure 8 is the front view structural schematic diagram of the manufacturing and processing method of the drug containing genetically recombinant antioxidant enzyme of the present invention; Figure 9 is the right view structural schematic diagram of the vertical clamping mechanism of the present invention; Figure 10 is the transmission structural schematic diagram of the linear linear slide rail, movable rack and synchronous gear in the transmission groove of the present invention; Figure 11 is the top view sectional structural schematic diagram of the polyethylene film edge being fitted under the guidance of the outer film guide plate and the inner film guide plate of the present invention; Figure 12 is the comparison diagram of the polyethylene film on the packaging bag winding cylinder and the packaging bag after hot melt plastic sealing and forming of the present invention; ​​In the figure: bottom support plate 1, bottom support foot 2, vertical chassis 3, packaging bag winding drum 4, polyethylene film 5, hopper support rod 6, bottom support frame 7, medicine granule hopper 8, granule spraying tube 9, wrapping shaping tube 10, inner film guide plate 11, vertical clamping and sealing mechanism 12, clamping strip support frame 1201, gear transmission support plate 1202, heat plastic sealing clamping strip 1 1203, heat sealing pressure strip 1 1204, heat plastic sealing clamping strip 2 1205, linear linear guide rail 1 206, movable rack 1207, synchronous gear 1208, linear push rod motor 1 1209, transmission slot 1210, electric bracket 3 1211, bag lifting mechanism 13, servo motor 1301, linear push rod motor 2 1302, lever 1303, horizontal frame 1304, vertical lifting rod 1305, lifting slot 1306, free motor bracket 1307, rotating wheel 1308, silicone disc 1 1309, Free bracket 1310, sliding support plate 1311, side linear guide 1312, silicone disc 2 1313, disc bracket 1314, side hot melt sealing line 14, double-sided locking and sealing mechanism 15, linear push rod motor 3 1501, fixed frame 2 1502, sliding support plate 1503, round rod linear guide 1504, rear hot melt support plate 1505, give way hot melt groove 1506, gate cutting groove 1507, heat sealing strip 2 1508, cutting knife 1510, cloth pushing roller 1511, liquid pressure cloth pushing 1512, roller bracket 1513, sliding bracket 1514, sliding groove 1515, sliding block 1516, movable bracket 1517, sliding shaft 1518, compression spring 1519, force unloading support plate 16, collection box 17, outer film guide plate 18, film guide pressure wheel 19. DETAILED DESCRIPTION

[0022] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific diagrams. It should be noted that the embodiments in this application and the features in the embodiments can be combined with each other without conflict.

[0023] Example 1 See also Figure 1 , is a schematic diagram of the overall structure of a method for producing and processing a drug containing a genetically recombinant antioxidant enzyme. S1. Collecting raw materials of various components: firstly, collecting and preparing raw materials of various components containing genetically recombinant antioxidant enzyme drugs, collecting and separating from animals and plants or purchasing various raw materials of glucan, oligofructose, oligogalactose, superoxide dismutase, vitamin C, prunes kernel powder, cassia seed powder, turmeric, sorbitol, hydroxypropyl methylcellulose, silicon dioxide and magnesium stearate from the market; S2. Synchronous production and processing on multiple production lines: Set up multiple factory workshops or multiple production lines in the same workshop. Each production line independently processes and manufactures various raw materials collected in step S1, and grinds and prepares the various raw materials collected in step S1 into fine particles to obtain powdery substances in the form of different raw material particles; S3. Big bag packaging: Quantitatively fill the powdery substances in the form of particles obtained in step S2 into polyethylene bags that are easy to seal and seal them. During the sealing process, first evacuate the air and then seal. The weight of the powdery particles filled into each polyethylene bag is controlled at 25KG, and the error range of the weight filled into the bag is no more than ±500G; each component of the powdery particles keeps the inside of the packaging bag dry and clean during the bagging process; S4. Storage and stacking: Store the powdery substances in the form of particles packed in bags in step S3 through polyethylene bags, and stack the neatly packaged powdery substances of each component around the corresponding production line or in the factory workshop where production takes place, waiting for the next transfer; S5. Material sorting and statistics: Set up a general pharmaceutical production workshop that meets pharmaceutical production standards, and transport and transfer the powdery substances of different material properties stacked around the corresponding production line or in the factory workshop where production takes place in step S4 to this pharmaceutical production workshop through polyethylene bags for packaging and logistics. In the pharmaceutical production workshop, count, sort, and analyze the powdery substances of each component used to prepare the antioxidant enzyme composition; S6. Uniform mixing: First put dextran powder, fructooligosaccharide powder, and galactooligosaccharide powder in the pharmaceutical production workshop into a homogenizer for homogenization, and then add superoxide dismutase powder, vitamin C powder, Prunus japonica powder, Cassia obtusifolia powder, turmeric powder, sorbitol powder, hypromellose powder, silicon dioxide powder, and magnesium stearate powder to the homogenized materials for homogenization treatment and water injection stirring; Add 3%-5% of water according to the total weight after homogenization and stir evenly; S7. Pill pressing and forming: Press and form pills in an environment with a temperature of 10-30°C and a humidity of 40%RH-55%RH to obtain pills containing the antioxidant enzyme composition; S8. Pill transfer: Transfer the pills obtained by pill pressing and forming to a pill hopper; S9. Pretreatment of the film bag: A vertical clamping and sealing mechanism and a bilateral locking and sealing mechanism are arranged at the bottom of the pill hopper. The vertical clamping and sealing mechanism first heat-seals the polyethylene film formed into a circular tube, and the bilateral locking and sealing mechanism heat-seals the bottom of the polyethylene film that has formed a circular tube; S10. Granule filling: The pills transferred to the pill hopper pass through the spraying tube at the bottom of the pill hopper and extend through the wrapping and shaping tube 10 to the bottom of the wrapping and shaping tube 10. The pills in the pill hopper are quantitatively ejected downward through the bottom of the spraying tube extending from the bottom of the wrapping and shaping tube 10 and fall into the tubular polyethylene film for packaging. S11. Dry powder sealing: The polyethylene film containing pills in step S10 falls downward by gravity into the double-sided sealing mechanism. The double-sided sealing mechanism heat-seals the top and bottom ends of the polyethylene film containing pills, and automatically cuts off at the middle position between the two heat-sealing lines to obtain small bag packages containing genetically recombinant antioxidant enzyme drug particles. S12. Collection and packing: The small bag particles obtained in step S11 fall into the collection box by gravity. The collection box collects the obtained small bag particles for later centralized packing.

[0024] Example 2 Please refer to Figures 2 - 12 , which is a schematic diagram of the overall structure of a manufacturing and processing method of a drug containing genetically recombinant antioxidant enzyme. This example has the same parts as the above Example 1, which will not be elaborated in this example. The specific differences are as follows: A manufacturing and processing method of a drug containing genetically recombinant antioxidant enzyme. The manufacturing and processing method described in steps S8 to S12 is mainly completed by a pill packaging machine. The pill packaging machine includes a bottom support plate 1. The bottom of the bottom support plate 1 is provided with bottom support feet 2. The top of the bottom support plate 1 is fixed with a vertical machine case 3 standing on the top of the bottom support plate 1. The top of the vertical machine case 3 is provided with a packaging bag winding cylinder 4. The packaging bag winding cylinder 4 is inclined and arranged on the top of the vertical machine case 3. The surface of the packaging bag winding cylinder 4 is wound with a polyethylene film 5. The top of the bottom support plate 1 is fixed with a hopper support rod 6 standing on the top of the bottom support plate 1. The surface of the hopper support rod 6 is fixedly installed with a bottom bracket 7. The top of the bottom bracket 7 is provided with a pill hopper 8. The pill hopper 8 is arranged above the packaging bag winding cylinder 4. The bottom of the pill hopper 8 is provided with a vertical spraying tube 9. The spraying tube 9 is arranged on the front surface of the vertical machine case 3. The outer wall of the spraying tube 9 is provided with a wrapping and shaping tube 10. The wrapping and shaping tube 10 wraps around the outer wall of the spraying tube 9. An outer film guiding plate 18 is arranged in front of the wrapping and shaping tube 10. The top surface of the outer film guiding plate 18 is an inclined surface. An inner film guiding plate 11 is arranged behind the wrapping and shaping tube 10. Guide film pressing wheels 19 are arranged on the surfaces of the inner film guiding plate 11 and the outer film guiding plate 18. The polyethylene film 5 wound around the packaging bag winding cylinder 4 is guided by the cooperation of the outer film guide plate 18 and the inner film guide plate 11 so that the polyethylene film 5 wraps around the outer wall of the wrapping and shaping tube 10. A vertical clamping mechanism 12 is arranged in the middle of the outer wall of the wrapping and shaping tube 10. The vertical clamping mechanism 12 is arranged at the bottom of the outer film guide plate 18. A bag separating and lifting mechanism 13 is arranged below the vertical clamping mechanism 12. A double-sided sealing mechanism 15 is arranged at the bottom of the bag separating and lifting mechanism 13. A force-relieving support piece 16 is arranged at the bottom of the double-sided sealing mechanism 15. A collection box 17 is arranged at the bottom of the force-relieving support piece 16.

[0025] Specifically, in this embodiment, the present invention is provided with a vertical machine case 3 on the top of the bottom support plate 1. A medicine granule hopper 8 is fixedly installed at the top of the vertical machine case 3. The medicine granule hopper 8 stores the prepared pill granules to be packaged. The pill granules are discharged downward through the spraying tube 9 in the medicine granule hopper 8. The surface of the packaging bag winding cylinder 4 at the top of the vertical machine case 3 is wound with a polyethylene film 5. The right edge of the polyethylene film 5 is guided by the inclined surface at the top of the outer film guide plate 18, so that the right edge of the polyethylene film 5 is guided along the inclined surface of the outer film guide plate 18 to the film guiding and pressing wheel 19 rotating on the surface of the outer film guide plate 18. The film guiding and pressing wheel 19 is used to roll and convey the right edge of the polyethylene film 5. The left edge of the polyethylene film 5 is conveyed downward through the guiding of the inner film guide plate 11. The middle of the polyethylene film 5 will wrap around the outer wall of the wrapping and shaping tube and be conveyed downward. The left edge of the polyethylene film 5 is rolled and conveyed through the film guiding and pressing wheel 19 rotatably connected to the surface of the inner film guide plate 11, so that the left edge and the right edge of the polyethylene film 5 are stretched to the corresponding positions on the left side of the wrapping and shaping tube, and the middle of the polyethylene film 5 is used to support and convey downward along the surface of the wrapping and shaping tube, so that the left edge and the right edge of the polyethylene film 5 stretched to the corresponding positions are conveyed downward to the vertical clamping mechanism 12. The vertical clamping mechanism 12 performs hot melt sealing on the left edge and the right edge of the polyethylene film 5 on the left side of the wrapping and shaping tube, completing the left sealing of the polyethylene film 5 to form a side hot melt sealing line 14. The polyethylene film 5 in the shape of a sheet is hot melt sealed into a circular tubular polyethylene film 5 through the side hot melt sealing line 14, and the bottom of the spraying tube 9 can be wrapped in the middle of the polyethylene film 5, which is convenient for filling pill granules into the middle of the polyethylene film 5. This design can realize the automatic continuous film supply of the packaging bag winding cylinder 4. The working position of the vertical clamping mechanism 12 is fixed, and the left side of the polyethylene film 5 can be continuously hot melt sealed, thus effectively improving the sealing efficiency.

[0026] The vertical clamping and sealing mechanism 12 includes a clamping bar support frame 1201 fixed to the top end of the vertical chassis 3. On the left and right sides of the front end of the clamping bar support frame 1201, there are symmetrically arranged gear transmission support plates 1202. At the top ends of the two side gear transmission support plates 1202, there is a third electric support 1211. The polyethylene film 5 wrapped around the outer wall of the wrapped plastic tube 10 extends downward from the middle parts of the two side gear transmission support plates 1202. On the inner wall surface of one of the gear transmission support plates 1202, there are a second heat-sealing plastic clamping bar 1205 and a first heat-sealing plastic clamping bar 1203. On the surface of the first heat-sealing plastic clamping bar 1203, there is a V-shaped hot-melt groove. On the surface of the second heat-sealing plastic clamping bar 1205, there is a first heat-sealing pressure bar 1204. On the surface of the first heat-sealing pressure bar 1204, there is a contour that matches the surface of the V-shaped hot-melt groove. Inside the V-shaped hot-melt groove, there is a tungsten wire to heat the inner wall of the V-shaped hot-melt groove, so that the inner wall of the V-shaped hot-melt groove can reach the temperature for hot-melting the polyethylene film 5 and maintain a constant temperature state. Thus, it is convenient for the first heat-sealing pressure bar 1204 to perform hot-melt sealing and pressing.

[0027] On the front end face of the third electric support 1211, there is a first linear push rod motor 1209 fixedly installed. On the inner wall surface of one of the gear transmission support plates 1202, there is a transmission groove 1210. On the top surface and the bottom surface of the inner wall of the transmission groove 1210, there are respectively linear straight slide rails 1206. On the surface of each linear straight slide rail 1206, there is a movable rack 1207 slidingly connected. At the middle position between the two movable racks 1207, there is a synchronous gear 1208. The synchronous gear 1208 is rotatably connected to the middle position of the inner wall of the transmission groove 1210. On the surface of one of the movable racks 1207, there is a first heat-sealing plastic clamping bar 1203 fixedly installed. On the surface of the other first heat-sealing plastic clamping bar 1203, there is a second heat-sealing plastic clamping bar 1205 fixedly installed. The second heat-sealing plastic clamping bar 1205 is fixedly connected to the top end of the push rod of the first linear push rod motor 1209.

[0028] Specifically, in this embodiment, the manufacturing and processing method of the drug containing genetically recombinant antioxidant enzyme provided by the present invention has high production efficiency, fast packaging speed, no manual operation required throughout the process, high degree of automation, and automatic separation of packaging bags. The manufacturing and processing method of the drug containing genetically recombinant antioxidant enzyme can efficiently seal the pill particles with a film bag. In the initial state, the middle part of the circular polyethylene film 5 is pre-melt sealed by the vertical clamping mechanism 12, and the bottom of the polyethylene film is heat-sealed in cooperation with the double-sided locking mechanism 15. Then, a fixed amount of pill particles are ejected from the bottom of the particle spraying tube 9. The fixed amount of pill particles are contained in the polyethylene film 5 heat-sealed on the left side and the bottom. Since the vertical clamping mechanism 12 is arranged above the bottom of the particle spraying tube 9, the height of the heat seal on the left side of the packaging film is higher than the bottom of the particle spraying tube 9, which can effectively prevent the fixed amount of pill particles ejected from the particle spraying tube 9 from spilling out. At this time, the bag separation and lifting mechanism 13 clamps the packaging film containing the fixed amount of pill particles and moves it downward to a predetermined height. The lower double-sided locking mechanism 15 clamps each other through the sliding support plate 1503 and the rear heat-sealing support plate 1505, and heat-seals the polyethylene film 5 extending into the double-sided locking mechanism 15 at two places. The two heat seals form two parallel heat-sealed plastic lines, and a quick cutting is performed at the adhesion position between the two parallel heat-sealed plastic lines, so that the adjacent two polyethylene films 5 are cut off and separated, improving the production, processing and packaging efficiency of the pill particles.

[0029] The bag separation and lifting mechanism 13 includes a free support 1310 arranged on the front end face of the vertical chassis 3. The free support 1310 is arranged to reciprocate and slide up and down on the front end face of the vertical chassis 3. Symmetrically fixed on the left and right sides at the front end of the free support 1310 are side linear guide rails 1312. The top ends of the two side linear guide rails 1312 are fixed with a disc support 1314. The polyethylene film 5 wrapped around the outer wall of the particle spraying tube 9 extends downward from the middle parts of the two free supports 1310. A sliding support plate 1311 is slidably connected to the middle parts of the two side linear guide rails 1312. Two silica gel discs 1309 are arranged on the surface of the sliding support plate 1311, and two silica gel discs 1313 corresponding to the silica gel discs 1309 are arranged on the surface of the disc support 1314.

[0030] Specifically, in this embodiment, the bag separation and lifting mechanism 13 provided by the present invention can reciprocate up and down under the particle spraying tube 9. During the downward free movement of the bag separation and lifting mechanism 13, the packaging film containing the fixed amount of pill particles is accurately dropped and supported to a fixed height, which can ensure that the size and volume of each packaging bag cut out by the double-sided locking mechanism 15 are the same, improving the accuracy of pill particle packaging.

[0031] A lifting slot 1306 that penetrates the rear end face of the vertical chassis 3 is provided in the middle of the vertical chassis 3. The rear end of the free bracket 1310 passes through the lifting slot 1306 and extends out towards the rear end face of the vertical chassis 3. A free motor bracket 1307 is slidably arranged on the rear end face of the vertical chassis 3. Limit blocks are arranged on the left and right sides of the rear end face of the vertical chassis 3 where the free motor bracket 1307 is located. The surfaces of the limit blocks are slidably connected to the left and right side ends of the free motor bracket 1307. The limit blocks perform left and right limits during the vertical lifting process of the free motor bracket 1307, which can effectively prevent the situation that the free motor bracket 1307 shakes and jams during the up and down reciprocating lifting and sliding process on the rear end face of the vertical chassis 3, and improve the lifting stability of the free motor bracket 1307. The rear end of the free bracket 1310 extending out of the rear end face of the vertical chassis 3 is fixedly connected to the free motor bracket 1307. A linear push rod motor two 1302 is fixedly installed at the top of the free motor bracket 1307. The linear push rod motor two 1302 extends a push rod towards the front end face of the free bracket 1310. The top of the push rod of the linear push rod motor two 1302 is fixedly installed with a sliding support plate 1311. By pushing the sliding support plate 1311 towards the direction of the disc bracket 1314 by the linear push rod motor two 1302, the two silicone discs two 1313 on the surface of the disc bracket 1314 are mutually attached and clamped with the corresponding silicone discs one 1309 to hold and move the polyethylene film 5 up and down.

[0032] A servo motor 1301 is fixedly installed on the rear end face of the vertical chassis 3. The servo motor 1301 extends a output shaft forward. A runner 1308 is installed at the top of the output shaft of the servo motor 1301. A dial rod 1303 is arranged on the outer wall of the runner 1308. The top of the dial rod 1303 is slidably connected to a cross frame 1304. A vertical lifting rod 1305 that stands upright at the bottom end of the cross frame 1304 is arranged at the bottom of the cross frame 1304. The top of the free motor bracket 1307 is fixed to the bottom of the vertical lifting rod 1305.

[0033] Specifically, in this embodiment, the bag splitting and lifting mechanism 13 provided by the present invention can reciprocate up and down freely below the spraying tube 9. During the downward free movement of the bag splitting and lifting mechanism 13, the packaging film containing the quantitative pill particles is accurately dropped and supported to a quantitative height, which can ensure that the size and volume of each packaging bag cut out by the double-sided sealing mechanism 15 are the same, and improve the accuracy of pill particle packaging.

[0034] Specifically, in this embodiment, the height difference of the up and down reciprocating free lifting of the free motor bracket 1307 depends on the length of the dial rod 1303. Therefore, the dial rod 1303 and the outer wall of the runner 1308 in this embodiment are detachably connected, which is convenient for later replacement of the dial rod 1303 with different lengths, so as to adjust the cutting size of the double-sided sealing mechanism 15 according to different packaging bag size requirements.

[0035] The force-releasing support piece 16 is a metal spring piece with an upright top and an arc-shaped bottom, and the surface of the force-releasing support piece 16 is a smooth arc-shaped surface.

[0036] Specifically, in the present embodiment, after each packaging bag is cut and packaged by the double-sided locking and sealing mechanism 15, the packaging bag is a plastic sealing film, and a certain amount of pill particles are contained inside the packaging bag. At this time, the packaging bag cut by the gate will fall downward quickly due to the gravity of the certain amount of pill particles. If it falls directly on the ground below or in the collection box 17, the impact of the fall will easily cause the pill particles to expand from the packaging bag and cause rupture. Therefore, the present invention uses a metal spring sheet with an upright top and an arc-shaped bottom to absorb gravity, slow down the descent speed, and effectively improve the safety of the packaging bag's landing. The packaging bag cut by the gate is guided by the upright unloading support sheet 16 to press the arc-shaped metal spring sheet at the bottom downward to deform. During the deformation process, the metal spring sheet absorbs a part of the impact load when the packaging bag falls, thereby making the packaging bag fall safer.

[0037] Example 3 See also Figures 2 - 12 , is a schematic diagram of the overall structure of a method for producing and processing a gene-recombinant antioxidant enzyme drug. This embodiment is similar to the above-mentioned embodiment 1 and embodiment 2, and the similarities are not described in this embodiment. The specific differences are: A method for producing and processing a drug containing a genetically recombinant antioxidant enzyme, wherein a bilateral locking and sealing mechanism 15 comprises a fixed frame 1502 fixed to the front end face of a vertical chassis 3, round rod linear guides 1504 are symmetrically arranged on the left and right sides of the front end face of the fixed frame 1502, rear hot melt support plates 1505 are fixedly installed on the top ends of the round rod linear guides 1504 on both sides, the bottom of the polyethylene film 5 wrapped around the bottom of the outer wall of a particle injection tube 9 extends into the middle of the round rod linear guides 1504 on both sides, the surface of the fixed frame 1502 is provided with a reciprocating horizontally sliding heat sealing strip 1508, there are two heat sealing strips 1508, a cutting knife 1510 is arranged in the middle position of the two heat sealing strips 1508, a surface of the rear hot melt support plate 1505 is provided with a yielding hot melt groove 1506 matched with the two heat sealing strips 1508, and a cutting knife 1510 is arranged in the middle position of the two yielding hot melt grooves 1506.

[0038] Specifically, the heat-melting groove 1506 of the present invention is a groove of a V-shaped structure, and the inner wall of the heat-melting groove 1506 is heated to a temperature capable of heat-melting the polyethylene film 5 by a metal tungsten wire, and the temperature is kept constant. The surface of the heat-sealing strip 1508 is provided with a profile matching the heat-melting groove 1506, so that the heat-melting plastic sealing area of ​​the polyethylene film 5 can be increased during the heat-melting process, the fastness of the heat-melting plastic sealing can be improved, the tightness of the sealing can be improved, the closeness of the edge of the packaging bag can be increased, and it is not easy to debond, the sealing safety is high, and the sealing speed is fast. The heat-melting plastic sealing groove 1506 of the V-shaped structure can quickly heat-melt the packaging film, and the heat-melt plastic sealing efficiency is high. After the heat-melting plastic sealing is completed, the adhesion position of the two heat-melting plastic sealing lines can be quickly cut by the double-sided locking mechanism 15, so that the two adjacent polyethylene films 5 are cut off and separated, thereby improving the production and processing efficiency of the pill particles.

[0039] A linear push rod motor 3 1501 is fixedly installed on the rear end face of the vertical chassis 3, and a push rod is extended from the linear push rod motor 3 1501 through the vertical chassis 3 to the middle of the front end of the fixed frame 2 1502. A sliding support plate 1503 is provided at the top end of the push rod of the linear push rod motor 3 1501, and the sliding support plate 1503 is parallel to the front end face of the vertical chassis 3. The front end face of the sliding support plate 1503 is provided with an inclined liquid pressure push cloth 1512, and the liquid pressure push cloth 1512 is flat, and the bottom of the inclined liquid pressure push cloth 1512 is inclined forward, and the bottom of the liquid pressure push cloth 1512 has a backward elastic retreat function.

[0040] Specifically, the heat-melting groove 1506 of the present invention is a groove of a V-shaped structure, and the inner wall of the heat-melting groove 1506 is heated to a temperature capable of heat-melting the polyethylene film 5 by a metal tungsten wire, and the temperature is kept constant. The surface of the heat-sealing strip 1508 is provided with a profile matching the heat-melting groove 1506, so that the heat-melting plastic sealing area of ​​the polyethylene film 5 can be increased during the heat-melting process, the fastness of the heat-melting plastic sealing can be improved, the tightness of the sealing can be improved, the closeness of the edge of the packaging bag can be increased, and it is not easy to debond, the sealing safety is high, and the sealing speed is fast. The heat-melting plastic sealing groove 1506 of the V-shaped structure can quickly heat-melt the packaging film, and the heat-melt plastic sealing efficiency is high. After the heat-melting plastic sealing is completed, the adhesion position of the two heat-melting plastic sealing lines can be quickly cut by the double-sided locking mechanism 15, so that the two adjacent polyethylene films 5 are cut off and separated, thereby improving the production and processing efficiency of the pill particles.

[0041] As for the polyethylene film 5 that moves downward into the double-sided sealing mechanism 15, the present invention pushes the sliding support plate 1503 to move toward the rear hot-melt support plate 1505 through the linear push rod motor 3 1501, and the liquid pressure push cloth 1512 that is inclinedly arranged on the front end surface of the sliding support plate 1503 will first contact the packaging film containing the quantitative pill particles, and as the sliding support plate 1503 continues to move forward, since the liquid pressure push cloth 1512 is inclined, the liquid pressure push cloth 1512 will push the quantitative pill particles in the packaging film to move upward. At the same time, since the liquid pressure push cloth 1512 is inclined, when the bottom of the liquid pressure push cloth 1512 touches the surface of the rear hot-melt support plate 1505, since the sliding support plate 1503 continues to move forward, the rear hot-melt support plate 1505 will push the liquid pressure push cloth The cloth 1512 generates an extrusion force, and the cloth pushing roller 1511 at the bottom of the pressure liquid pushing cloth 1512 is in close contact with the surface of the rear hot melt support plate 1505 at this time, and as the sliding support plate 1503 continues to move forward, the surface of the pressure liquid pushing cloth 1512 gradually fits upward from the bottom to the surface of the rear hot melt support plate 1505, thereby pushing the quantitative pill particles in the packaging film upward, realizing a lifting action, and moving the quantitative pill particles in the packaging film away from the hot melt plastic sealing area, so that the heat sealing strip 1508 under the sliding support plate 1503 and the giving way hot melt groove 1506 are hot-melted, which can effectively reduce the influence of the pill particles on the hot melt plastic sealing area, thereby significantly reducing the phenomenon of loose hot melt plastic sealing and incomplete sealing, and effectively improving the production yield of pill particles.

[0042] Specifically, the present invention provides a cloth pushing roller 1511 at each end of the inner circle of the liquid pressure push cloth 1512, and the liquid pressure push cloth 1512 is inclined. When the bottom of the liquid pressure push cloth 1512 touches the surface of the rear hot melt support plate 1505, as the sliding support plate 1503 continues to move forward, the rear hot melt support plate 1505 will generate an extrusion force on the liquid pressure push cloth 1512. At this time, the cloth pushing roller 1511 at the bottom of the liquid pressure push cloth 1512 is in close contact with the surface of the rear hot melt support plate 1505, and as the sliding support plate 1503 continues to move forward, the cloth pushing roller 1511 on the top of the roller support 1513 moves along the roller support The cloth pushing roller 1511 at the bottom of the frame 1513 swings with the center axis, so that the cloth pushing roller 1511 at the top of the roller bracket 1513 rolls on the inner wall of the liquid pressing cloth 1512. At this time, the liquid pressing cloth 1512 in close contact with the surface of the rear hot melt support plate 1505 remains fixed, so that the surface of the liquid pressing cloth 1512 can push the surface of the packaging film from bottom to top and press it obliquely. During the pressing process, the surface of the liquid pressing cloth 1512 will not roll and rub the surface of the packaging film, so that the quantitative pill particles inside the packaging film can be squeezed upward, while effectively improving the safety of the packaging film during the squeezing process.

[0043] A cloth-pushing roller 1511 is provided at each end of the inner circle of the pressure liquid cloth-pushing roller 1512, and a roller bracket 1513 is provided in the middle of the two cloth-pushing rollers 1511 for support, and the cloth-pushing rollers 1511 can rotate freely at both ends of the roller bracket 1513. The cloth-pushing rollers 1511 near the top of the pressure liquid cloth-pushing roller 1512 are rotatably connected to a movable bracket 1517 at the left and right ends, and a sliding block 1516 is provided at the top of each movable bracket 1517. A sliding frame 1514 is provided at the front end surface of the sliding support plate 1503 near the top surface of the sliding support plate 1503, and the sliding block 1516 is slidably connected to the surface of the sliding frame 1514, and the sliding block 1516 can be lifted and slid reciprocatingly up and down on the surface of the sliding frame 1514. The cloth pushing roller 1511 at the top of the roller bracket 1513 swings along the cloth pushing roller 1511 at the bottom of the roller bracket 1513 as the central axis, and the sliding block 1516 reciprocates up and down on the surface of the sliding frame 1514 to move out of position, so that the cloth pushing roller 1511 can swing along a predetermined trajectory.

[0044] The cloth pushing roller 1511 near the bottom end of the liquid pressure cloth pushing 1512 is rotatably connected to a sliding shaft 1518 at both ends, and the surface of the sliding support plate 1503 near the bottom end surface of the sliding support plate 1503 is provided with two through circular holes, and each sliding shaft 1518 is slidably connected to the circular hole on the surface of the sliding support plate 1503, and a compression spring 1519 is provided in the middle of the surface of each sliding shaft 1518.

[0045] The give-way hot melt groove 1506 is a groove of V-shaped structure, and the inner wall of the give-way hot melt groove 1506 is heated to a temperature capable of hot-melting the polyethylene film 5 by a metal tungsten wire, and maintained at a constant temperature. The heat-sealing pressure strip 2 1508 can increase the hot-melt plastic sealing area of ​​the polyethylene film 5 in the process of extruding the polyethylene film into the give-way hot melt groove 1506 for hot melting, improve the tightness of the hot-melt plastic sealing, improve the tightness of the sealing, increase the closeness of the edge of the packaging bag, and is not easy to debond, with high sealing safety and fast sealing speed. The give-way hot melt groove 1506 of V-shaped structure can quickly perform hot-melt plastic sealing on the packaging film, and the hot-melt plastic sealing efficiency is high. After the hot-melt plastic sealing is completed, the adhesion position of the two hot-melt plastic sealing lines can be quickly cut through the double-sided locking and sealing mechanism 15, so that the two adjacent polyethylene films 5 are cut off and separated, thereby improving the production and processing efficiency of the pill particles.

[0046] A stirring rod for uniform mixing is arranged inside the medicine pellet hopper 8, and the stirring rod for uniform mixing is used to uniformly stir the pill particles poured into the medicine pellet hopper 8, so that the pill particles in the medicine pellet hopper 8 always maintain a uniform formulation. At the same time, a powder metering pump with precise control is arranged inside the medicine pellet hopper 8, and the powder metering pump can precisely control the spraying dosage of the particle spraying tube 9, thereby effectively and precisely controlling the precise packaging amount of the pill particles during the production and packaging process.

[0047] The wrapping and shaping tube 10 is a hollow flat tube with a flat rear end and an arc-shaped front end. The wrapping and shaping tube 10 is fixed to the front end face of the vertical chassis 3 through a bracket. The spraying tube 9 at the bottom of the medicine granule hopper 8 passes through the middle of the wrapping and shaping tube 10 and extends towards the bottom of the wrapping and shaping tube 10.

[0048] The film guiding and pressing wheel 19 is rotatably installed at the corner positions of the inner film guiding plate 11 and the outer film guiding plate 18. The film guiding and pressing wheel 19 can pull the edge of the polyethylene film 5 wound around the surface of the packaging bag winding cylinder 4, so as to carry out a distributed positioning and unfolding of the edge of the polyethylene film 5 wound around the surface of the packaging bag winding cylinder 4 along a predetermined trajectory.

[0049] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The descriptions in the above embodiments and the specification only illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. A method for producing a drug containing a genetically recombinant antioxidant enzyme, characterized in that: It includes the following steps: S1. Collecting raw materials of various components: firstly, collecting and preparing raw materials of various components containing genetically recombinant antioxidant enzyme drugs, collecting and separating from animals and plants or purchasing various raw materials of glucan, oligofructose, oligogalactose, superoxide dismutase, vitamin C, prunes kernel powder, cassia seed powder, turmeric, sorbitol, hydroxypropyl methylcellulose, silicon dioxide and magnesium stearate from the market; S2. Synchronous production and processing of multiple production lines: multiple factory workshops are set up or multiple production lines are set up in the same workshop, each production line independently produces and processes various raw materials collected in step S1, and the various raw materials collected in step S1 are prepared and ground into fine particles to obtain powders of different raw material particles; S3, big bag packaging: quantitatively pack the granular powder obtained in step S2 into an easily sealable polyethylene bag and seal it. During the sealing process, vacuum is first applied and then sealed. The weight of each bag of granular powder packed in the polyethylene bag is controlled to be 25 kg, and the error range of packing in the bag is not more than 500 g. The granular powder of each component is kept dry and clean in the bag during the packing process; S4, storage and stacking: the granular powder packaged in step S3 is sealed and stored in polyethylene bags, and the neatly packaged granular powders of each component are stacked around the corresponding production line or in the production factory workshop, waiting for the next step of transportation and transfer; S5. Material sorting and statistics: a general pharmaceutical production workshop is set up, which meets the pharmaceutical production standards, and the granular powders of different material properties that are stacked around the corresponding production line or in the production factory workshop in step S4 are packaged and transported to the pharmaceutical production workshop in polyethylene bags, and the granular powders of each component for preparing the antioxidant enzyme composition are counted, sorted and analyzed in the pharmaceutical production workshop; S6. Evenly mix the materials: firstly put the dextran powder, oligofructose powder and oligogalactose powder in the pharmaceutical production workshop into a homogenizer for homogenization, then add superoxide dismutase powder, vitamin C powder, prunes powder, cassia seed powder, turmeric powder, sorbitol powder, hydroxypropyl methylcellulose powder, silicon dioxide powder and magnesium stearate powder into the homogenized materials for homogenization, and then stir with water; add 3%-5% water according to the total weight after homogenization and stir evenly; S7, pelleting: pelleting in an environment with a temperature of 10-30° C. and a humidity of 40% RH-55% RH to obtain a pill-shaped antioxidant enzyme-containing composition; S8, pill transfer: transfer the pills obtained by pill pressing into the pill hopper; S9, film bag pretreatment: a vertical clamping and sealing mechanism and a double-sided locking and sealing mechanism are arranged at the bottom of the granule hopper, the vertical clamping and sealing mechanism pre-heat-melt-seals the polyethylene film formed into a circular tube, and the double-sided locking and sealing mechanism pre-heat-melt-seals the bottom of the polyethylene film formed into a circular tube; S10, filling of medicine pellets: the pills transferred into the medicine pellet hopper pass through the spraying tube at the bottom of the medicine pellet hopper and extend toward the bottom of the wrapping molding tube, and the medicine pellets in the medicine pellet hopper are quantitatively sprayed downward through the bottom of the spraying tube extending from the bottom of the wrapping molding tube and fall into the cylindrical polyethylene film for filling; S11, dry powder sealing: the polyethylene film containing the drug particles in step S10 falls downward into the double-sided locking and sealing mechanism by gravity, the top and bottom of the polyethylene film containing the drug particles are hot-melt sealed by the double-sided locking and sealing mechanism, and the gate is automatically cut off at the middle position of the two hot-melt sealing lines to obtain the drug particles containing the genetically recombinant antioxidant enzyme packaged in small bags; S12, collection and packaging: the small bags of particles prepared in step S11 fall into a collection box by gravity, and the small bags of particles prepared are collected by the collection box for centralized packaging later.

2. The method for preparing a drug containing a genetically recombinant antioxidant enzyme according to claim 1, characterized in that: The manufacturing and processing method described in steps S8 to S12 is mainly completed by a medicine pellet packaging machine, which includes a bottom support plate fixed to the ground, a vertical chassis upright on the top of the bottom support plate is fixed on the top of the bottom support plate, a packaging bag winding drum is arranged on the top of the vertical chassis, and the packaging bag winding drum is inclinedly arranged on the top of the vertical chassis, and a polyethylene film is wound on the surface of the packaging bag winding drum; the medicine pellet hopper is arranged above the packaging bag winding drum, and a vertical particle spraying pipe is arranged at the bottom of the medicine pellet hopper, and a wrapping molding pipe is arranged on the outer wall of the particle spraying pipe, and an outer film guide plate is arranged in front of the wrapping molding pipe, and an inner film guide plate is arranged behind the wrapping molding pipe, and the surface of the inner film guide plate and the surface of the outer film guide plate are both provided with film guide pressing wheels; The polyethylene film wound on the packaging bag winding drum is guided by the outer film guide plate and the inner film guide plate so that the polyethylene film is wrapped on the outer wall of the wrapping molding tube, a vertical clamping and sealing mechanism is arranged in the middle of the outer wall of the wrapping molding tube, the vertical clamping and sealing mechanism is arranged at the bottom of the outer film guide plate, a bag separation and lifting mechanism is arranged below the vertical clamping and sealing mechanism, a double-sided locking and sealing mechanism is arranged at the bottom of the double-sided locking and sealing mechanism, a force-releasing support plate is arranged at the bottom of the force-releasing support plate, and a collection box is arranged at the bottom of the force-releasing support plate.

3. The method for preparing a drug containing a genetically recombinant antioxidant enzyme according to claim 2, characterized in that: The bilateral locking and sealing mechanism includes a fixed frame 2 fixed to the front end face of the vertical chassis, and round rod linear guides are symmetrically arranged on the left and right sides of the front end face of the fixed frame 2, and rear hot-melt support plates are fixedly installed on the top ends of the round rod linear guides on both sides, and the bottom of the polyethylene film wrapped around the bottom of the outer wall of the particle injection tube extends into the middle of the round rod linear guides on both sides, and the surface of the fixed frame 2 is provided with reciprocating horizontally sliding heat-sealing strips 2, and there are two heat-sealing strips in total, and a cutting knife is arranged in the middle position of the two heat-sealing strips 2, and a yielding hot-melt groove cooperating with the two heat-sealing strips 2 is opened on the surface of the rear hot-melt support plate, and a cutting knife is arranged in the middle position of the two yielding hot-melt grooves.

4. The method for preparing a drug containing a genetically recombinant antioxidant enzyme according to claim 3, characterized in that: A linear push rod motor three is fixedly installed on the rear end face of the vertical chassis, and a push rod is extended from the linear push rod motor three through the vertical chassis to the middle of the front end of the fixed frame two. A sliding support plate is provided at the top end of the push rod of the linear push rod motor three, and the sliding support plate is parallel to the front end face of the vertical chassis. A tilted liquid pressure push cloth is provided on the front end face of the sliding support plate, and the liquid pressure push cloth is a plane, and the bottom of the tilted liquid pressure push cloth is tilted forward, and the bottom of the liquid pressure push cloth has a backward elastic retreat function.

5. The method for preparing a drug containing a genetically recombinant antioxidant enzyme according to claim 4, characterized in that: A cloth pushing roller is arranged at each end of the inner circle of the pressure liquid cloth pushing roller, and a roller bracket is arranged in the middle of the two cloth pushing rollers for support, and the cloth pushing roller can rotate freely at the two ends of the roller bracket; the left and right ends of the cloth pushing roller close to the top end of the pressure liquid cloth pushing roller are rotatably connected with a movable bracket, and a sliding block is arranged at the top end of each of the movable brackets, and a sliding bracket is arranged at the front end surface of the sliding support plate close to the top end surface of the sliding support plate, and the sliding block is slidably connected to the surface of the sliding bracket, and the sliding block can be lifted and slid reciprocatingly up and down on the surface of the sliding bracket.

6. The method for preparing a drug containing a genetically recombinant antioxidant enzyme according to claim 4, characterized in that: The left and right ends of the cloth pushing roller near the bottom end of the liquid pressure cloth pushing device are rotatably connected with a sliding shaft rod, and the surface of the sliding support plate near the bottom end surface of the sliding support plate is provided with two through circular holes, and each sliding shaft rod is slidably connected to the circular hole on the surface of the sliding support plate, and a compression spring is arranged in the middle of the surface of each sliding shaft rod.

7. The method for preparing a drug containing a genetically recombinant antioxidant enzyme according to claim 2, characterized in that: The vertical clamping and sealing mechanism includes a clamping strip supporting frame fixed to the top of the vertical chassis, and gear transmission support plates are symmetrically arranged on the left and right sides of the front end of the clamping strip supporting frame, and electric brackets three are fixed to the top of the gear transmission support plates on both sides, and the polyethylene film wrapped on the outer wall of the wrapping molding tube extends downward from the middle of the gear transmission support plates on both sides, and the inner wall surface of the gear transmission support plate on one side is provided with a heat plastic sealing clamping strip two and a heat plastic sealing clamping strip one, and the surface of the heat plastic sealing clamping strip one is provided with a V-shaped hot melt groove, and the surface of the heat plastic sealing clamping strip two is provided with a heat sealing strip one, and the surface of the heat sealing strip one is provided with a contour matching the surface of the V-shaped hot melt groove.

8. The method for preparing a drug containing a genetically recombinant antioxidant enzyme according to claim 2, characterized in that: The bag-distributing lifting mechanism includes a free bracket arranged on the front end surface of a vertical chassis, the free bracket is arranged on the front end surface of the vertical chassis to slide and lift back and forth, side linear guides are symmetrically fixedly installed on the left and right sides of the front end of the free bracket, disc brackets are fixed on the top ends of the side linear guides on both sides, the polyethylene film wrapped on the outer wall of the particle spraying tube extends downward from the middle of the free bracket on both sides, the middle parts of the side linear guides on both sides are slidably connected with sliding support plates, the surface of the sliding support plate is provided with two silicone discs 1, and the surface of the disc bracket is provided with two silicone discs 2 corresponding to the silicone disc 1.

9. The method for preparing a drug containing a genetically recombinant antioxidant enzyme according to claim 2, characterized in that: The force unloading support piece is a metal spring piece with an upright top and an arc-shaped bottom, and the surface of the force unloading support piece is a smooth arc-shaped surface.

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