Formula for treating gout as well as preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and particularly discloses a formula for treating gout and a preparation method and application thereof.The traditional Chinese medicine formula is prepared from, by weight, 8-10 parts of saffron crocus, 6-8 parts of rhizoma acori calami, 8-15 parts of radix gentianae macrophyllae, 5-8 parts of herba portulacae, 3-5 parts of radix platycodonis, 5-8 parts of honey, 2-5 parts of liquorice extract and 1-2 parts of citric acid. According to the invention, natural medicinal materials such as saffron crocus, acorus calamus, gentiana macrophylla, purslane and platycodon grandiflorum are carefully selected, and auxiliary materials such as honey, a licorice extract and citric acid are combined, so that an efficient formula aiming at gout diseases is formed. The medicinal materials and the auxiliary materials have good effects of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness, clearing away heat and toxic materials and the like in the theory of traditional Chinese medicine, can achieve a synergistic effect and effectively relieve symptoms such as arthralgia and swelling caused by gout.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a formula for treating gout, a preparation method thereof, and an application thereof. Background Art

[0002] Worldwide, gout, as a common metabolic joint disease, has an increasing incidence year by year, bringing severe physical pain and life troubles to patients. Especially in remote or underdeveloped areas with uneven distribution of medical resources, the effective treatment of gout has become an urgent problem to be solved. Although modern medicine has made certain progress in the treatment of gout, there are still challenges such as drug side effects and high treatment costs. At the same time, some patients are intolerant to traditional chemical drugs or seek more natural and mild treatment methods.

[0003] Under this background, it is particularly important to search for and develop an efficient, safe, convenient and affordable treatment method for gout. Natural drugs in traditional medicine have gradually become a research hotspot due to their unique pharmacological effects and fewer side effects. However, many natural drugs, especially those derived from plant, animal or mineral raw materials, often have problems such as low content of active ingredients, poor stability and inconvenient administration without modern processing, which greatly limits their wide application in clinical practice.

[0004] Therefore, in view of the need for gout treatment, it has become an urgent task to develop an efficient, stable and convenient preparation based on natural drugs. Summary of the Invention

[0005] The purpose of the present invention is to provide a formula for treating gout, a preparation method thereof, and an application thereof, so as to solve the problems raised in the above background art.

[0006] To achieve the above purpose, the present invention provides the following technical solutions:

[0007] A formula for treating gout, comprising the following raw materials in parts by weight: 8 - 10 parts of saffron, 6 - 8 parts of acorus calamus, 8 - 15 parts of gentiana macrophylla, 5 - 8 parts of portulaca oleracea, 3 - 5 parts of platycodon grandiflorum, 5 - 8 parts of honey, 2 - 5 parts of licorice extract, and 1 - 2 parts of citric acid.

[0008] Preferably, it comprises the following raw materials in parts by weight: 8 parts of saffron, 6 parts of acorus calamus, 8 parts of gentiana macrophylla, 5 parts of portulaca oleracea, 5 parts of platycodon grandiflorum, 5 parts of honey, 3 parts of licorice extract, and 1 part of citric acid.

[0009] A preparation method of a formula for treating gout, comprising the following steps:

[0010] S1. Selection of medicinal materials:

[0011] Purchase saffron, acorus calamus, gentiana macrophylla, purslane, and platycodon grandiflorum traditional Chinese medicine materials, and then conduct acceptance inspection on the materials to ensure that the materials are free from mildew, insect damage, impurities, and meet the medicinal standards.

[0012] S2. Cleaning and Drying:

[0013] Clean the materials with running water to remove the dust and impurities on the surface, and dry the cleaned materials to avoid mildew or affecting the extraction effect during the subsequent extraction process.

[0014] S3. Crushing Treatment:

[0015] Use a DF-20 type traditional Chinese medicine crusher to crush the dried materials to a size between 0.5 and 1 mm, and sieve them through a 300-mesh sieve. Re-crush the crushed materials that do not meet the requirements to ensure passing through the 300-mesh sieve.

[0016] S4. Mixing and Homogenization

[0017] Mix the crushed material powder with auxiliary materials such as honey, licorice extract, and lemon evenly according to the formula ratio; use an I KN three-stage high-shear homogenizer to stir until all components are fully integrated.

[0018] S5. pH Value Adjustment:

[0019] Use a pH meter such as a PHS-3C type pH meter to detect the pH value of the mixed powder. According to the detection results, use an appropriate amount of acid-base regulator, such as dilute hydrochloric acid or sodium hydroxide solution, to adjust to ensure that the pH value of the powder is controlled within an appropriate range, generally 4.5 - 7.5.

[0020] S6. Sterilization Treatment

[0021] Conduct sterilization treatment on the evenly mixed powder. Select the high-temperature and high-pressure sterilization method. Place the powder in a sterilizer and sterilize it at 121°C for 15 - 20 minutes to ensure that the powder is sterile.

[0022] S7. Drying and Packaging:

[0023] Place the powder in a drying equipment to dry, remove the excess moisture, and ensure the dryness of the powder. After drying, use sterile packaging materials to divide the powder into packages of specified doses, conduct bagging, and perform sealing treatment.

[0024] S8. Quality Inspection and Labeling:

[0025] Conduct quality inspection on the packaged powder, including appearance, color, smell, pH value, uniformity, stability, and microbial limit indicators; after passing the inspection, affix a label on the package, indicating the drug name, specifications, usage and dosage, production date, expiration date, production batch number, and manufacturer information.

[0026] A formula for treating gout is applied to a powder.

[0027] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0028] The present invention selects natural medicinal materials such as saffron, acorus calamus, gentiana macrophylla, purslane, platycodon grandiflorum, etc., and combines auxiliary materials such as honey, licorice extract, and citric acid to form an efficient formula for treating gout. These medicinal materials and auxiliary materials have good effects of promoting blood circulation and removing blood stasis, dispelling wind and dampness, clearing heat and detoxifying, etc. in traditional Chinese medicine theory, and can act synergistically to effectively relieve symptoms such as joint pain and swelling caused by gout. Through a series of modern preparation steps such as strict selection, cleaning, drying, pulverization, homogenization, pH adjustment, sterilization, and dry packaging of the medicinal materials, the present invention ensures the high quality of the powder. At the same time, the powder form prepared by the present invention is convenient for patients to carry and take, without complicated operations such as decocting, greatly improving the convenience of patients' medication. Moreover, by adjusting the taste and taking method, the powder is made more in line with the living habits of modern people, improving the acceptance and compliance of patients. Detailed implementation manners

[0029] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0030] Embodiment 1:

[0031] A formula for treating gout:

[0032] Raw material formula (by weight):

[0033] Saffron: 8 parts

[0034] Acorus calamus: 6 parts

[0035] Gentiana macrophylla: 8 parts

[0036] Purslane: 5 parts

[0037] Platycodon grandiflorum: 5 parts

[0038] Honey: 5 parts

[0039] Licorice extract: 3 parts

[0040] Citric acid: 1 part

[0041] II. Preparation method

[0042] Selection of medicinal materials:

[0043] Purchase the above traditional Chinese medicine materials from reputable suppliers to ensure that all materials meet pharmaceutical standards, without mildew, insect damage, or impurities.

[0044] Washing and Drying:

[0045] Thoroughly wash the materials with running water to remove surface dust and impurities.

[0046] Place the washed materials in a cool and well-ventilated place to dry naturally, or use low-temperature drying equipment for rapid drying to ensure that the materials are thoroughly dried and prevent mildew.

[0047] Grinding Process:

[0048] Use a DF-20 type traditional Chinese medicine grinder to grind the dried materials to a particle size of 0.5 - 1 mm.

[0049] Pass through a 300-mesh sieve. Re-grind the ground materials that do not pass through the sieve until all materials can pass through the 300-mesh sieve.

[0050] Mixing and Homogenization:

[0051] Accurately weigh and mix the ground material powder with auxiliary materials such as honey, licorice extract, and citric acid according to the formula ratio.

[0052] Use an IKN three-stage high-shear homogenizer to fully stir the mixture to ensure uniform distribution of each component and form a homogeneous mixture.

[0053] pH Value Adjustment:

[0054] Use a PHS-3C type pH meter to detect the pH value of the mixture.

[0055] According to the test results, use dilute hydrochloric acid or sodium hydroxide solution to finely adjust the pH value of the mixture to ensure it is within the appropriate range of 4.5 - 7.5.

[0056] Sterilization Treatment:

[0057] Place the uniformly mixed powder in a high-temperature and high-pressure sterilizer, set the temperature to 121 °C, and the sterilization time to 15 - 20 minutes to ensure the powder is sterile.

[0058] Drying and Packaging:

[0059] Place the sterilized powder in a drying equipment to remove excess moisture and ensure the powder is dry.

[0060] Use sterile packaging materials to divide the powder into bags according to the specified dosage and seal it to ensure that the powder is not contaminated during storage and transportation.

[0061] Quality Inspection and Labeling:

[0062] Conduct a comprehensive quality inspection on the packaged powder, including indicators such as appearance, color, odor, pH value, uniformity, stability, and microbial limit.

[0063] After passing the inspection, affix a label on the package, indicating the drug name (such as "Gout Treatment Powder"), specification (such as "XX grams per bag"), usage and dosage, production date, expiration date, production batch number, production manufacturer information, etc.

[0064] Example 2:

[0065] A formula for treating gout:

[0066] Saffron: 9 parts

[0067] Acorus calamus: 7 parts

[0068] Gentiana macrophylla: 10 parts

[0069] Portulaca oleracea: 6 parts

[0070] Platycodon grandiflorum: 4 parts

[0071] Honey (natural wild honey): 6 parts

[0072] Licorice extract (high purity): 4 parts

[0073] Citric acid (food grade): 1.5 parts

[0074] Extra addition: Microcrystalline cellulose as a filler to improve the fluidity of the powder, appropriate amount

[0075] II. Preparation method

[0076] Preparation of medicinal materials and excipients:

[0077] Select the above-mentioned medicinal materials, ensure reliable sources, high quality, no mildew, insect damage or impurities.

[0078] The excipients are selected as high-quality natural wild honey, high-purity licorice extract and food-grade citric acid, and microcrystalline cellulose as a filler.

[0079] Washing and drying:

[0080] Wash the medicinal materials with purified water to remove surface dirt, and then place them in a cool and ventilated place to dry naturally or use a low-temperature drying equipment to dry, ensuring that the medicinal materials are dry and maintain their original medicinal effects.

[0081] Fine grinding:

[0082] Use an improved traditional Chinese medicine grinder to grind the medicinal materials to a finer particle size (about 0.3 - 0.8 mm) to improve the release and solubility of the active ingredients.

[0083] Pass through a 400-mesh sieve to ensure that all medicinal powder can pass through, improving the uniformity and stability of the product.

[0084] Mixing and homogenization:

[0085] Accurately weigh the crushed medicinal powder and excipients (honey, licorice extract, citric acid, microcrystalline cellulose) according to the formula ratio.

[0086] Use a high-efficiency rotary mixer for mixing to ensure uniform distribution of each component. Subsequently, through ultrasonic homogenization treatment, further promote the fusion and dispersion of components.

[0087] Precise pH adjustment:

[0088] Use a precision pH meter to detect the pH value of the mixture, and accurately adjust it with a trace amount of dilute hydrochloric acid or sodium hydroxide solution as needed to ensure that the pH value is stable between 4.8 - 7.2 to optimize the taste and stability of the product.

[0089] Low-temperature sterilization:

[0090] Adopt low-temperature plasma sterilization technology to sterilize the mixed powder, ensuring both the sterility of the product and avoiding the influence of high temperature on the medicinal effect.

[0091] Drying and packaging optimization:

[0092] Use vacuum drying equipment to dry the powder at low temperature, removing excess moisture while maintaining the active ingredients of the medicinal materials.

[0093] The packaging uses aluminum foil bags with deoxidizers added to ensure the freshness and stability of the product during long-term storage. Detailed product information and usage and dosage instructions are printed on each bag.

[0094] Strict quality control:

[0095] Conduct a comprehensive quality inspection on each batch of products, including but not limited to the inspection of indicators such as appearance, color, smell, pH value, uniformity, stability, microbial limit, heavy metals, and pesticide residues.

[0096] Qualified products will be affixed with anti-counterfeiting labels indicating the drug name, specifications, usage and dosage, production date, expiration date, production batch number, manufacturer information, and anti-counterfeiting code, etc.

[0097] Example 3:

[0098] A formula for treating gout:

[0099] Saffron: 10 parts (promoting blood circulation to remove blood stasis and promoting local blood circulation)

[0100] Acorus calamus: 8 parts (removing dampness and dredging collaterals to relieve joint swelling and pain)

[0101] Gentiana macrophylla Pall.: 12 parts (Clearing heat and promoting diuresis, reducing inflammatory response)

[0102] Portulaca oleracea L.: 7 parts (Assisting in reducing local uric acid deposition)

[0103] Platycodon grandiflorum (Jacq.) A. DC.: 3 parts (Regulating the properties of medicinal herbs and promoting drug penetration)

[0104] Honey (fused with natural beeswax): 5 parts (Enhancing the adhesiveness of the powder and protecting the skin)

[0105] Licorice extract (standardized): 5 parts (Anti-inflammatory and anti-allergic, reducing skin irritation)

[0106] Citric acid (naturally extracted): 1.5 parts (Adjusting the pH value of the powder and enhancing skin adaptability)

[0107] Additional additives: Menthol 2 parts (Cooling and relieving pain, alleviating local itching), Borneol 1 part (Enhancing transdermal absorption and quickly relieving pain)

[0108] Preparation process:

[0109] Medicinal material treatment: All medicinal materials are strictly screened, washed, dried, and sterilized to ensure the purity of the medicinal materials without impurities, while retaining their natural active ingredients.

[0110] Ultra-fine grinding and nanotechnology: Advanced ultra-fine grinding technology is used to grind the medicinal materials to the nanoscale, greatly improving the release rate of the effective components of the medicinal materials and their skin permeability. Ultra-fine grinding technology refers to the powder processing technology that grinds the material particles with a particle size of 0.55 mm to the micron level (1 - 100 μm), sub-micron level (0.1 - 1 μm), or even nanoscale (1 - 100 nm).

[0111] Intelligent mixing and homogenization: An intelligent mixing system is used to precisely control the mixing ratio and speed according to the characteristics of the medicinal materials to ensure the uniform distribution of each component. Subsequently, through high-pressure homogenization technology, the particles are further refined to enhance the fineness and stability of the powder.

[0112] Precise pH value regulation: Using a precision pH meter, according to the physiological characteristics of the skin, the pH value of the powder is precisely adjusted to 5.8 - 6.2, which not only protects the skin but also promotes the efficacy of the drug.

[0113] III. Packaging design and user experience

[0114] Innovative packaging: An environmentally friendly and breathable aluminum-plastic composite bag is used, with a desiccant inside to ensure that the powder remains dry and fresh during storage. The packaging is printed with detailed usage guidelines, ingredient descriptions, and safety warnings for the convenience of patients to use correctly.

[0115] Convenient usage design: Each bag of powder is equipped with a special measuring spoon to ensure the accurate dosage for patients each time. Meanwhile, a soft applicator stick is attached inside the powder box, which is convenient for patients to evenly apply it on the affected area, reducing direct hand contact and improving hygiene.

[0116] It should be understood that in the development of any actual implementation, such as in any engineering or design project, a large number of specific implementation decisions can be made. Such development efforts may be complex and time-consuming, but for those of ordinary skill in the art who benefit from this disclosure, without excessive experimentation, the development efforts will be a routine task of design, manufacture, and production.

[0117] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention, and they should all be covered within the scope of the claims of the present invention.

Claims

1. A formula for treating gout, characterized in that: The invention comprises the following raw materials in parts by weight: 8-10 parts of saffron, 6-8 parts of Tibetan calamus, 8-15 parts of gentiana macrophylla, 5-8 parts of purslane, 3-5 parts of platycodon, 5-8 parts of honey, 2-5 parts of liquorice extract and 1-2 parts of citric acid.

2. A formula for treating gout according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 8 parts of saffron, 6 parts of Tibetan calamus, 8 parts of gentiana macrophylla, 5 parts of purslane, 5 parts of platycodon, 5 parts of honey, 3 parts of liquorice extract and 1 part of citric acid.

3. A method for preparing a formula for treating gout, characterized in that: The following steps are involved: S1. Selection of medicinal materials: Purchase saffron, calamus, qinjiao, purslane, platycodon and other Chinese medicinal materials, and then inspect and accept them to ensure that they are free of mold, insects, impurities, and meet the medicinal standards; S2. Cleaning and drying: Use running water to wash the medicinal materials to remove dust and impurities on the surface, and dry the washed medicinal materials to avoid mildew or affect the extraction effect during the subsequent extraction process; S3, crushing treatment: Use the DF-20 Chinese medicine grinder to grind the dried medicinal materials into pieces between 0.5-1 mm, and sieve them through a 300-mesh sieve. Grind the medicinal materials that do not meet the requirements again to ensure that they pass the 300-mesh sieve. S4. Mixing and homogenization Mix the crushed medicinal powder with the auxiliary materials honey, licorice extract and lemon according to the formula ratio; use an IKN three-stage high shear homogenizer to stir until all the ingredients are fully blended; S5. pH adjustment: Use a pH meter such as PHS-3C pH meter to test the pH value of the mixed powder. According to the test results, use an appropriate amount of acid-base regulator, such as dilute hydrochloric acid or sodium hydroxide solution, to ensure that the pH value of the powder is controlled within the appropriate range, generally 4.5-7.5; S6. Sterilization Sterilize the evenly mixed powder by high temperature and high pressure sterilization. Place the powder in a sterilizer and sterilize at 121°C for 15-20 minutes to ensure that the powder is sterile. S7. Drying and packaging: The powder is placed in a drying device to dry, remove excess moisture, and ensure the dryness of the powder. After drying, the powder is packaged into packages of prescribed doses using sterile packaging materials, bagged, and sealed; S8, Quality Inspection and Labeling: The packaged powders are subject to quality inspection, including appearance, color, odor, pH value, uniformity, stability, and microbial limit indicators; after passing the inspection, a label is affixed to the package, indicating the drug name, specifications, usage and dosage, production date, expiration date, production batch number, and manufacturer information.

4. A formula for treating gout according to claim 1, characterized in that: For use in powders.