Temperature-sensitive suppository for eliminating pelvic inflammation and preparation method and drug delivery device of temperature-sensitive suppository

Abstract

The invention discloses a Chinese patent medicine for treating gynecological inflammatory diseases, and particularly discloses a pelvic inflammation temperature-sensitive suppository as well as a preparation method and a drug delivery device.The pelvic inflammation temperature-sensitive suppository is prepared from the following raw materials in parts by weight: 30-60 parts of polygonum cuspidatum, 30-40 parts of sargentgloryvine stem, 20-30 parts of radix isatidis, 20-30 parts of honeysuckle, 20-30 parts of golden cypress, 20-30 parts of patrinia, 30-40 parts of salvia miltiorrhiza, 20-30 parts of ligusticum wallichii, 20-30 parts of corydalis tuber, 20-30 parts of achyranthes bidentata and 20-30 parts of rhizoma cyperi. 20-30 parts of selfheal and 10-20 parts of liquorice. The dosing device is arranged, through autolysis of medicine, the medicine stored in the medicine storage cavity breaks through the diaphragm and enters the water storage cavity, the medicine and water are mixed to form mixed liquid, then the mixed liquid enters the rectum focus of a patient and is absorbed through the temperature of the human body, positioning type dosing is achieved, the dosing precision is high, and the dosing effect is good. And adverse factors such as intestinal wall stimulation and obvious foreign body sensation caused by enema and various suppositories are avoided, and the formula raw materials and the proportion of all components are optimized, so that a better treatment effect is achieved.

Description

Technical Field

[0001] The present invention discloses a Chinese patent medicine for treating gynecological inflammatory diseases, in particular, discloses a Penyanxiao thermosensitive suppository and its preparation method and administration device. Background Art

[0002] Pelvic inflammatory disease refers to an inflammation of the uterus, fallopian tubes, ovaries, pelvic connective tissue and pelvic peritoneum in a woman's pelvic cavity. The main pathogens of this disease are aerobic bacteria, simple anaerobic bacteria or mixed infections of aerobic bacteria and anaerobic bacteria. The pathogenic bacteria include streptococcus, staphylococcus, Escherichia coli and anaerobic bacteria, mycoplasma, Chlamydia trachomatis, etc. According to its pathogenesis, it is clinically divided into acute and chronic types. Its main clinical manifestations include lower abdominal pain, lumbosacral soreness, excessive vaginal discharge, abdominal mass or fever. There is no disease name of "pelvic inflammatory disease" in traditional Chinese medical literature. According to its clinical manifestations, it is classified into diseases such as "abdominal pain in women", "leukorrhea", "irregular menstruation", "abdominal mass", "dysmenorrhea" and "infertility". Pelvic inflammatory disease is a common and frequently-occurring disease in gynecology. Since the pelvic cavity is located relatively deep, once inflammation occurs, if the treatment is not thorough or timely, acute pelvic inflammatory disease is very likely to turn into chronic. Chronic pelvic inflammatory disease has a long course, relapses frequently, and gets better and worse from time to time, seriously affecting women's health, life and work.

[0003] For the treatment of pelvic inflammation, antibiotics are the first choice in China. Due to the application of broad-spectrum antibiotics, life-threatening acute pelvic inflammatory disease has been controlled, but the treatment effect of antibiotics for chronic pelvic inflammatory disease is not ideal. If antibiotics are used for a long time and in large amounts, it will cause serious damage to liver and kidney functions and drug resistance to antibiotics.

[0004] In the prior art, Patent CN102631589B discloses a Penyanxiao enema solution and its preparation method, which is made into a liquid preparation with a variety of effective ingredients and directly administered by enema. The drug is directly absorbed through the rectal mucosa, reaching the lesion site with the advantages of short distance, high local drug concentration, large contact area, short course of treatment, good curative effect and satisfactory treatment effect.

[0005] However, the above patent solution has the following technical problems:

[0006] 1. The enema solution is not convenient for transportation, carrying and storage, and is easy to be damaged;

[0007] 2. The operation of administering the enema solution is inconvenient, it is easy to overflow and cause pollution, and it will also lead to the problem of insufficient drug dosage;

[0008] 3. Administering the enema solution will stimulate the intestinal wall and cause discomfort symptoms;

[0009] 4. Although the enema solution is administered rectally, it lacks the cooperation of an administration device, making it difficult to achieve targeted administration and unable to directly reach the lesion site;

[0010] 5. With the development of medicine, the raw materials of this formula need to be adjusted and improved to achieve better therapeutic effects.

[0011] In addition, the prior art also discloses various types of suppositories such as anal plugs and hollow plugs. However, the suppositories are administered through the anus and are easily expelled from the body if not properly operated. At the same time, the foreign body sensation is obvious, causing discomfort symptoms, and it is difficult to reach the lesion site. The drug delivery devices equipped with various suppositories are mostly plastic push rods, which are inconvenient to operate and easily cause damage to the anus. Summary of the invention

[0012] In order to solve the above technical problems, the present invention discloses a pelvic inflammation temperature-sensitive suppository and a preparation method and a drug delivery device thereof.

[0013] The technical scheme adopted by the present invention is: a pelvic inflammation anti-temperature sensitive suppository is made of the following raw materials in parts by weight: 30-60 parts of polygonum cuspidatum, 30-40 parts of saffron vine, 20-30 parts of isatis root, 20-30 parts of honeysuckle, 20-30 parts of phellodendron, 20-30 parts of patrinia herb, 30-40 parts of salvia miltiorrhiza, 20-30 parts of ligusticum chuanxiong, 20-30 parts of corydalis, 20-30 parts of cyperus, 20-30 parts of prunella vulgaris and 10-20 parts of liquorice.

[0014] Preferably, the polygonum cuspidatum is 50 parts, the saffron caulis is 35 parts, the isatis root is 20 parts, the honeysuckle is 20 parts, the phellodendron is 20 parts, the patrinia herb is 20 parts, the salvia miltiorrhiza is 40 parts, the chuanxiong is 20 parts, the corydalis is 20 parts, the cyperus is 20 parts, the rhizome of cyperus is 20 parts, the selfheal is 20 parts, and the liquorice is 10 parts.

[0015] A method for preparing a pelvic inflammation-relieving temperature-sensitive suppository comprises the following steps:

[0016] (1) Weigh 30-60 parts of Polygonum cuspidatum, 30-40 parts of Sargentodoxae, 20-30 parts of Radix Isatidis, 20-30 parts of Flos Lonicerae, 20-30 parts of Cortex Phellodendri, 20-30 parts of Herba Patriniae, 30-40 parts of Radix Salviae Miltiorrhizae, 20-30 parts of Rhizoma Chuanxiong, 20-30 parts of Rhizoma Corydalis, 20-30 parts of Radix Cyperi, 20-30 parts of Spica Prunellae, and 10-20 parts of Radix Glycyrrhizae by using an electronic balance, and preliminarily crush the above raw materials by using a crushing device;

[0017] (2) mixing the raw materials after preliminary crushing in step (1), and then putting them into an ultrafine grinder for ball milling for 15-20 minutes to make the mixed raw material particles uniformly crushed to 600-800 mesh, and then filtering them through a sieve for the first time to filter out coarse impurities;

[0018] (3) boiling the mixed raw material particles uniformly crushed in step (2) for 5 minutes, and then filtering them for a second time;

[0019] (4) Dry the mixed raw materials that have completed the second filtration in step (3) to evaporate the moisture and form powder particles of the medicine.

[0020] In a method for preparing a pelvic inflammation relieving temperature-sensitive suppository, preferably, there are 50 parts of polygonum cuspidatum, 35 parts of sargentodoxa cuneata, 20 parts of isatis root, 20 parts of honeysuckle flower, 20 parts of phellodendron amurense, 20 parts of patrinia scabiosaefolia, 40 parts of salvia miltiorrhiza, 20 parts of ligusticum wallichii, 20 parts of rhizoma corydalis, 20 parts of achyranthes bidentata, 20 parts of cyperus rotundus, 20 parts of prunella vulgaris, and 10 parts of licorice.

[0021] A drug delivery device includes a storage cavity and a push rod that are detachably connected. The storage cavity is composed of a water storage cavity and a medicine storage cavity that are arranged in sequence from top to bottom. A diaphragm is arranged between the water storage cavity and the medicine storage cavity. A limit card is arranged between the push rod and the storage cavity. The medicine stored in the medicine storage cavity is powder particles of the medicine prepared by the method for preparing a pelvic inflammation relieving temperature-sensitive suppository.

[0022] Preferably, the push rod is a two-stage push rod. The first stage of pushing enables the medicine stored in the medicine storage cavity to break through the diaphragm and enter the water storage cavity, so that the medicine is mixed with water to form a mixed solution. The second stage of pushing enables the mixed solution to enter the rectal lesion of the patient.

[0023] Preferably, the outer wall of the water storage cavity is a food fiber membrane.

[0024] Preferably, gelatin ribs for reinforcement are arranged on the outer wall of the storage cavity.

[0025] Beneficial effects

[0026] The advantages and positive effects of the present invention are:

[0027] 1. The powder particles of the medicine are convenient for transportation and storage;

[0028] 2. Through ball milling and pulverization by an ultrafine pulverizer, the purity of the powder particles of the medicine is higher, and intestinal irritation caused by the traditional alcohol extraction method is avoided;

[0029] 3. A drug delivery device is provided. Through the self-dissolution of the medicine, the medicine stored in the medicine storage cavity breaks through the diaphragm and enters the water storage cavity, so that the medicine is mixed with water to form a mixed solution. Then, the mixed solution enters the rectal lesion of the patient and is absorbed through the human body temperature, realizing targeted drug delivery with high drug delivery accuracy, and avoiding adverse factors such as irritation of the intestinal wall and obvious foreign body sensation caused by enema fluid and various suppositories;

[0030] 4. The formula raw materials and the ratio of each component are optimized to achieve a better therapeutic effect. Specific embodiments

[0031] The present invention will be further described below in conjunction with specific embodiments:

[0032] A pelvic inflammation-relieving temperature-sensitive suppository is prepared from the following raw materials in parts by weight: 30-60 parts of polygonum cuspidatum, 30-40 parts of sargentodoxa cuneata, 20-30 parts of isatis root, 20-30 parts of honeysuckle flower, 20-30 parts of phellodendron amurense, 20-30 parts of patrinia scabiosaefolia, 30-40 parts of salvia miltiorrhiza, 20-30 parts of ligusticum wallichii, 20-30 parts of rhizoma corydalis, 20-30 parts of achyranthes bidentata, 20-30 parts of cyperus rotundus, 20-30 parts of prunella vulgaris, and 10-20 parts of liquorice.

[0033] Preferably, it is prepared from 50 parts of polygonum cuspidatum, 35 parts of sargentodoxa cuneata, 20 parts of isatis root, 20 parts of honeysuckle flower, 20 parts of phellodendron amurense, 20 parts of patrinia scabiosaefolia, 40 parts of salvia miltiorrhiza, 20 parts of ligusticum wallichii, 20 parts of rhizoma corydalis, 20 parts of achyranthes bidentata, 20 parts of cyperus rotundus, 20 parts of prunella vulgaris, and 10 parts of liquorice.

[0034] A preparation method of a pelvic inflammation-relieving temperature-sensitive suppository comprises the following steps:

[0035] (1) Weigh 30-60 parts of polygonum cuspidatum, 30-40 parts of sargentodoxa cuneata, 20-30 parts of isatis root, 20-30 parts of honeysuckle flower, 20-30 parts of phellodendron amurense, 20-30 parts of patrinia scabiosaefolia, 30-40 parts of salvia miltiorrhiza, 20-30 parts of ligusticum wallichii, 20-30 parts of rhizoma corydalis, 20-30 parts of achyranthes bidentata, 20-30 parts of cyperus rotundus, 20-30 parts of prunella vulgaris, and 10-20 parts of liquorice by an electronic balance, and respectively conduct preliminary pulverization on the above raw materials through a pulverization device;

[0036] (2) Mix the preliminarily pulverized raw materials in step (1), then put them into an ultrafine pulverizer for ball milling pulverization for 15-20 minutes to make the mixed raw material particles evenly pulverized to reach 600-800 meshes, and then conduct the first filtration through a sieve to filter out coarse impurities;

[0037] (3) Conduct preliminary boiling treatment on the evenly pulverized mixed raw material particles in step (2) for 5 minutes, and then conduct the second filtration;

[0038] (4) Conduct drying treatment on the mixed raw materials that have completed the second filtration in step (3) to evaporate the moisture to form medicine powder particles.

[0039] In a preparation method of a pelvic inflammation-relieving temperature-sensitive suppository, preferably, it is prepared from 50 parts of polygonum cuspidatum, 35 parts of sargentodoxa cuneata, 20 parts of isatis root, 20 parts of honeysuckle flower, 20 parts of phellodendron amurense, 20 parts of patrinia scabiosaefolia, 40 parts of salvia miltiorrhiza, 20 parts of ligusticum wallichii, 20 parts of rhizoma corydalis, 20 parts of achyranthes bidentata, 20 parts of cyperus rotundus, 20 parts of prunella vulgaris, and 10 parts of liquorice.

[0040] A drug delivery device, comprising a storage chamber and a push rod detachably connected. The storage chamber consists of a water storage chamber and a drug storage chamber arranged in sequence from top to bottom. A diaphragm is provided between the water storage chamber and the drug storage chamber. A limit card is provided between the push rod and the storage chamber. The drug stored in the drug storage chamber is powder particles prepared by the preparation method of Penyanxiao thermosensitive suppository.

[0041] Preferably, the push rod is a two-stage push rod. The first stage of pushing enables the drug stored in the drug storage chamber to break through the diaphragm and enter the water storage chamber, so that the drug is mixed with water to form a mixed solution. The second stage of pushing enables the mixed solution to enter the rectal lesion of the patient.

[0042] Preferably, the outer wall of the water storage chamber is a food fiber membrane.

[0043] Preferably, the outer wall of the storage chamber is provided with gelatin ribs for reinforcement.

[0044] The above has described the embodiments of the present invention in detail, but the content is only the preferred embodiments of the present invention and cannot be considered as limiting the scope of implementation of the present invention. All equal changes and improvements made according to the scope of the application of the present invention shall still fall within the scope covered by the patent of the present invention.

Claims

1. A pelvic inflammation temperature-sensitive plug, characterized in that: The invention is prepared from the following raw materials in parts by weight: 30-60 parts of polygonum cuspidatum, 30-40 parts of saffron caulis thunbergii, 20-30 parts of isatis root, 20-30 parts of honeysuckle, 20-30 parts of phellodendron, 20-30 parts of patrinia herb, 30-40 parts of salvia miltiorrhiza, 20-30 parts of ligusticum chuanxiong, 20-30 parts of corydalis yanhusuo, 20-30 parts of cyperus rotundus, 20-30 parts of selfheal, and 10-20 parts of liquorice.

2. The pelvic inflammation-relieving temperature-sensitive plug according to claim 1, characterized in that: The polygonum cuspidatum is 50 parts, the saffron caulis is 35 parts, the isatis root is 20 parts, the honeysuckle is 20 parts, the phellodendron is 20 parts, the patrinia herb is 20 parts, the salvia miltiorrhiza is 40 parts, the ligusticum chuanxiong is 20 parts, the corydalis is 20 parts, the cyperus is 20 parts, the rhizoma annuae is 20 parts, the rhizoma cyperi is 20 parts, the herb prunella vulgaris is 20 parts and the liquorice is 10 parts.

3. A method for preparing a pelvic inflammation-relieving temperature-sensitive suppository, characterized in that: The steps include: (1) Weigh 30-60 parts of Polygonum cuspidatum, 30-40 parts of Sargentodoxae, 20-30 parts of Radix Isatidis, 20-30 parts of Flos Lonicerae, 20-30 parts of Cortex Phellodendri, 20-30 parts of Herba Patriniae, 30-40 parts of Radix Salviae Miltiorrhizae, 20-30 parts of Rhizoma Chuanxiong, 20-30 parts of Rhizoma Corydalis, 20-30 parts of Radix Cyperi, 20-30 parts of Spica Prunellae, and 10-20 parts of Radix Glycyrrhizae by using an electronic balance, and preliminarily crush the above raw materials by using a crushing device; (2) mixing the raw materials after preliminary crushing in step (1), and then putting them into an ultrafine grinder for ball milling for 15-20 minutes to make the mixed raw material particles uniformly crushed to 600-800 mesh, and then filtering them through a sieve for the first time to filter out coarse impurities; (3) boiling the mixed raw material particles uniformly crushed in step (2) for 5 minutes, and then filtering them for a second time; (4) Drying the mixed raw material after the second filtration in step (3) to evaporate the water and form powder particles.

4. The method for preparing the temperature-sensitive suppository for pelvic inflammation according to claim 3, characterized in that: The polygonum cuspidatum is 50 parts, the saffron caulis is 35 parts, the isatis root is 20 parts, the honeysuckle is 20 parts, the phellodendron is 20 parts, the patrinia herb is 20 parts, the salvia miltiorrhiza is 40 parts, the ligusticum chuanxiong is 20 parts, the corydalis is 20 parts, the cyperus is 20 parts, the rhizoma annuae is 20 parts, the rhizoma cyperi is 20 parts, the herb prunella vulgaris is 20 parts and the liquorice is 10 parts.

5. A drug delivery device, comprising a detachably connected storage chamber and a push rod, wherein the storage chamber is composed of a water storage chamber and a drug storage chamber arranged in sequence from top to bottom, a diaphragm is arranged between the water storage chamber and the drug storage chamber, a limit card is arranged between the push rod and the storage chamber, and the drug stored in the drug storage chamber is the powder particles described in claim 3.

6. The drug delivery device according to claim 5, characterized in that: The push rod is a two-stage push rod. The first stage pushes the medicine stored in the medicine storage cavity to break through the diaphragm and enter the water storage cavity, so that the medicine and water are mixed to form a mixed liquid. The second stage pushes the mixed liquid into the rectal lesion of the patient.

7. The drug delivery device according to claim 6, characterized in that: The outer wall of the water storage cavity is a food fiber membrane.

8. The drug delivery device according to claim 7, characterized in that: The outer wall of the storage cavity is provided with gelatin ribs for reinforcement.