Method for generating hydrophilic monodisperse aerosol with different particle sizes for human body to inhale

Abstract

The invention relates to the field of intelligent medical treatment, in particular to a method for generating hydrophilic monodisperse aerosol with different particle sizes for human body inhalation. Comprising the following steps: acquiring hydrophilic aerosol generating liquid; conveying the hydrophilic aerosol generating liquid into an aerosol generator to obtain first monodisperse hydrophilic aerosol; the aerosol generator comprises a polydisperse aerosol generator and an aerosol particle size sorter, and the hydrophilic aerosol generating liquid generates polydisperse hydrophilic aerosol through the polydisperse aerosol generator; the polydisperse hydrophilic aerosol is screened by the aerosol particle size sorter to obtain the first monodisperse hydrophilic aerosol with different particle sizes, deposition distribution of the hydrophilic monodisperse aerosol with radioactivity in the respiratory tract of the human body can be obtained, and the method has good research value.

Description

Technical Field

[0001] This application relates to the field of intelligent medicine, and particularly to a method, device, program product, and computer-readable storage medium for generating hydrophilic monodisperse aerosols with different particle sizes for human inhalation. Background Art

[0002] Most drugs are hydrophilic particulate matters. However, most of the current inhalation studies on human targeted drugs adopt the technology of generating inhalable polydisperse non-radioactive hydrophobic aerosols. At the same time, there is no reliable closed inhalation device for human radioactive aerosols. Therefore, it is impossible to obtain a reliable high-resolution quantitative deposition distribution of targeted drugs similar to drugs. In 2007, Jakob first studied the total deposition rate of nanoscale (50 - 150nm) polydisperse hydrophobic particulate matters in the respiratory tract using an atomizing device. The study found that as the particle size increases, the total deposition rate of the particles gradually decreases. In 2017, Rissler et al. first used a polydisperse aerosol generating device to roughly quantitatively study the total deposition rate of polydisperse hydrophobic particulate matters in the respiratory tract in the particle size range of 15 - 5000nm. The study found that for particulate matters in the range of 15 - 300nm, the total deposition rate gradually decreases as the particle size increases; for particulate matters in the range of 300 - 5000nm, the total deposition rate gradually increases as the particle size increases. The above studies can only obtain the total deposition rate of hydrophobic polydisperse aerosol particles. Therefore, it is impossible to obtain the deposition distribution characteristics of each region of the respiratory tract, and the guiding significance for existing clinical drug targeted therapy is limited. Summary of the Invention

[0003] In view of the above problems, the present invention provides a method for generating hydrophilic monodisperse aerosols with different particle sizes for human inhalation, specifically including: Obtaining a hydrophilic aerosol generating liquid; Transporting the hydrophilic aerosol generating liquid to an aerosol generator to obtain a first monodisperse hydrophilic aerosol; the aerosol generator includes a polydisperse aerosol generator and an aerosol aerodynamic particle size sorter. The hydrophilic aerosol generating liquid generates a polydisperse hydrophilic aerosol through the polydisperse aerosol generator, and the polydisperse hydrophilic aerosol is screened by the aerosol particle size sorter to obtain first monodisperse hydrophilic aerosols with different particle sizes.

[0004] The first monodisperse hydrophilic aerosols with different particle sizes are monodisperse hydrophilic aerosols with particle sizes less than or equal to 3μm.

[0005] Optionally, the aerosol generator further includes a monodisperse aerosol generator, and the monodisperse aerosol generator and the polydisperse aerosol generator are in a non-interfering parallel relationship. The hydrophilic aerosol generating liquid obtains a second monodisperse hydrophilic aerosol through the monodisperse aerosol generator.

[0006] Optionally, the second monodisperse aerosol is a monodisperse hydrophilic aerosol with a size greater than 3 μm.

[0007] Optionally, the aerosol generator further includes a medical nebulizer, which has a parallel relationship with the polydisperse aerosol generator and the monodisperse aerosol generator without interference. The hydrophilic aerosol generating liquid passes through the medical nebulizer to obtain a polydisperse hydrophilic aerosol.

[0008] The hydrophilic aerosol generating liquid is a radioactive hydrophilic aerosol generating liquid; the radioactive hydrophilic aerosol generating liquid is transported to the aerosol generator to obtain a radioactive first monodisperse hydrophilic aerosol.

[0009] Optionally, the preparation process of the radioactive hydrophilic aerosol generating liquid is as follows: Obtain a radioactive isotope and hydrophilic particles; Add the radioactive isotope to ultrapure water to obtain a mixed solution; Add the hydrophilic particles to the mixed solution, shake well and perform ultrasonic treatment to obtain a radioactive hydrophilic aerosol generating liquid.

[0010] Optionally, the radioactive isotope includes 18 F-FDG solution.

[0011] Optionally, the hydrophilic particles include glucose.

[0012] Optionally, the execution time of the ultrasonic treatment is 8 - 12 minutes.

[0013] The purpose of the present invention is to provide a quantitative method for the deposition distribution of hydrophilic aerosol in the respiratory tract, including: Obtain a radioactive hydrophilic aerosol according to the above method for generating hydrophilic monodisperse aerosols with different particle sizes for human inhalation. The hydrophilic aerosol includes one or more of the following: the first monodisperse hydrophilic aerosol, the second monodisperse hydrophilic aerosol, and the polydisperse hydrophilic aerosol; After the subject inhales the hydrophilic aerosol, tomographically scan the subject's respiratory tract to obtain the subject's image data; Based on the subject's image data, obtain the deposition distribution map of the hydrophilic aerosol in the respiratory tract.

[0014] The method further includes tail gas recovery. After the subject inhales the hydrophilic aerosol from the inhalation tower, the remaining radioactive hydrophilic aerosol in the inhalation tower and the exhalation tower is recovered.

[0015] The purpose of the present invention is to provide a method for constructing a prediction model for the deposition distribution of hydrophilic particles, including: Obtain the deposition distribution data set of the subject according to the quantitative method of the deposition distribution of the hydrophilic aerosol in the respiratory tract, with hydrophilic aerosols of different particle sizes as labels; Input the data set and labels into a neural network for training until the loss function remains unchanged to obtain a deposition prediction model.

[0016] The object of the present invention is to provide a prediction method for the deposition distribution of hydrophilic aerosol particles of different particle sizes, including: Obtain the particle size of the hydrophilic aerosol inhaled by the subject; Input the particle size into the deposition prediction model obtained by the above deposition prediction model construction method based on the deposition distribution of hydrophilic particles for prediction to obtain a deposition distribution prediction map.

[0017] The object of the present invention is to provide a computer program product, which includes a computer program or instruction, and the computer program or instruction is executed by a processor to implement the above method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, or to implement the above prediction method for the deposition distribution of hydrophilic aerosols in the respiratory tract, or to implement the above prediction model construction method based on the deposition distribution of hydrophilic particles, or to implement the above prediction method for the deposition distribution of hydrophilic aerosol particles of different particle sizes.

[0018] The object of the present invention is to provide a computer device, which includes a memory, a processor, and a computer program or instruction stored on the memory, and the computer program or instruction is executed by the processor to implement the above method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, or to implement the above quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract, or to implement the above prediction model construction method for the deposition distribution of hydrophilic particles, or to implement the above prediction method based on the deposition distribution of hydrophilic aerosol particles of different particle sizes.

[0019] The object of the present invention is to provide a computer-readable storage medium, which stores a computer program or instruction, and the computer program or instruction is executed by a processor to implement the above method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, or to implement the above method for generating a deposition distribution map of hydrophilic aerosols in the respiratory tract, or to implement the above prediction model construction method for the deposition distribution of hydrophilic particles, or to implement the above prediction method for the deposition distribution of hydrophilic aerosol particles of different particle sizes.

[0020] Advantages of the present invention: 1. The aerosols generated by the aerosol generating device for human inhalation are all non-radioactive polydisperse, and mostly hydrophobic particulate matters. At the same time, there is no reliable radioactive closed inhalation device, which cannot meet the high-resolution real quantitative analysis of hydrophilic aerosol particulate matters in the respiratory tract. The present invention provides a method for generating hydrophilic aerosol monodispersion, which helps to observe the deposition distribution of monodisperse in the human respiratory tract, and further helps to understand the deposition distribution law of hydrophilic monodisperse aerosol in the human respiratory tract, providing a research basis for subsequent diagnosis and treatment. Precise targeted drug delivery requires accurate deposition of drugs at the lesion site and reduction of drug deposition in healthy areas to minimize harm to the body. There are significant differences in the deposition distribution of aerosols with different particle sizes. The generation of monodisperse aerosol can obtain the deposition distribution of particulate matters with different particle sizes and the difference in deposition mechanisms of particulate matters with different particle sizes. However, polydisperse contains multiple particle sizes, and its deposition area is relatively wide, making it impossible to achieve precise targeted drug delivery of drugs.

[0021] 2. The aerosol generation method of the present invention can adjust to obtain particles of different particle sizes, providing conditions for the deposition distribution of different particle sizes in the human respiratory tract, helping to understand the deposition trajectories and laws of different particle sizes, and providing assistance for the localization of harmful substances in the respiratory tract and the targeted treatment of aerosol drugs in the later stage. Compared with the existing human inhalation aerosol generation, the present invention can generate monodisperse and polydisperse radioactive glucose, which can achieve precise analysis of the deposition differences of different particle sizes in the respiratory tract. At the same time, the human inhalation exposure device designed in this study can not only achieve leak-free inhalation of aerosols, but also accurately obtain the total deposition rate of the respiratory tract.

[0022] 3. In order to present the distribution of hydrophilic monodisperse aerosol particles with different particle sizes in the respiratory tract, the present invention proposes a radioactive hydrophilic aerosol, which is ultrasonically treated with radioactive isotopes and hydrophilic particles to improve the preparation efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are only some embodiments of the present invention. For those skilled in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0024] Figure 1 Schematic flow chart of the method for generating hydrophilic monodisperse aerosol with different particle sizes for human inhalation provided by the embodiment of the present invention; Figure 2 Schematic diagram of the system for generating hydrophilic monodisperse aerosol with different particle sizes for human inhalation provided by the embodiment of the present invention; Figure 3Schematic diagram of a hydrophilic monodisperse aerosol generating device for human inhalation provided by an embodiment of the present invention; Figure 4 Preparation process of a radioactive hydrophilic aerosol provided by an embodiment of the present invention; Preparation of radioactive aerosol generating solutions of different concentrations of glucose; Figure 5 Generation process of monodisperse / polydisperse hydrophilic aerosol provided by an embodiment of the present invention; Monodisperse and polydisperse radioactive glucose aerosol generation system; Figure 6 Aerosol particle size spectrum diagram provided by an embodiment of the present invention; Particle size spectrum diagrams of 0.7μm and 3μm monodisperse aerosols; Figure 7 Tail gas recovery process provided by an embodiment of the present invention; Human aerosol lung deposition quantification system and aerosol tail gas recovery system; Figure 8 PET-CT images of the deposition distribution of glucose particles in the human respiratory tract provided by an embodiment of the present invention; Inhalation deposition distribution diagram of 0.2μm hydrophilic monodisperse aerosol. Detailed implementation manners

[0025] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0026] In some processes described in the specification, claims and above-mentioned drawings of the present invention, a plurality of operations appear in a specific order. However, it should be clearly understood that these operations may not be executed in the order in which they appear herein or may be executed in parallel. The serial numbers of the operations, such as S101, S102, etc., are only used to distinguish different operations, and the serial numbers themselves do not represent any execution order. In addition, these processes may include more or fewer operations, and these operations may be executed in sequence or in parallel. It should be noted that the descriptions such as "first" and "second" in this article are used to distinguish different messages, devices, modules, etc., and do not represent a sequence, nor do they limit that "first" and "second" are of different types.

[0027] Figure 1 Schematic diagram of a method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation provided by an embodiment of the present invention, specifically including: S101: Obtain a hydrophilic aerosol generating solution; In one embodiment, the hydrophilic aerosol generating solution is a radioactive hydrophilic aerosol generating solution; The radioactive hydrophilic aerosol generating solution is transported to an aerosol generator to obtain a radioactive first monodisperse hydrophilic aerosol.

[0028] In one embodiment, the preparation process of the radioactive hydrophilic aerosol generating liquid is as follows: Obtain a radioactive isotope and hydrophilic particles; Add the radioactive isotope to ultrapure water to obtain a mixed solution; Add the hydrophilic particles to the mixed solution, shake well, and perform ultrasonic treatment to obtain a radioactive hydrophilic aerosol generating liquid.

[0029] In one embodiment, the radioactive isotope includes 18 F-FDG solution.

[0030] In one embodiment, the hydrophilic particles include glucose.

[0031] In one embodiment, the execution time of the ultrasonic treatment is 8 - 12 minutes.

[0032] In a specific embodiment, the preparation of the radioactive hydrophilic aerosol: Experimental materials: The raw materials mainly include ultrapure glucose (Thermo Scientific, USA), ultrapure water, 18 F-FDG, human lung deposition quantification device (Huironghe Technology Co., Ltd.), TSI3321 aerodynamic particle size spectrometer, TSI scanning mobility particle size spectrometer (TSI3756, TSI3081A, TSI3082, TSI3088), cascade filter (Huironghe Technology Co., Ltd.), flow meter (Huironghe Technology Co., Ltd.), valve (Huironghe Technology Co., Ltd.), air pump (Huironghe Technology Co., Ltd.), aerodynamic particle size separator (Cambustion, UK).

[0033] Add 10 mCi 18 F-FDG and 10 mL of ultrapure water into a test tube and shake well to prepare 18 F-FDG solution. As Figure 4 shown, then calculate the mass of glucose to be added according to the particle size of the generated aerosol and the liquid aerosol generator manual, and then add glucose to 18 F-FDG solution, shake the solution well, and perform ultrasonic treatment for ten minutes to obtain an aerosol generating liquid. Finally, add the generating liquid to the generator to generate monodisperse and polydisperse aerosols.

[0034] S102: Deliver the hydrophilic aerosol generating liquid to an aerosol generator to obtain a first monodisperse hydrophilic aerosol. The aerosol generator includes a polydisperse aerosol generator and an aerosol particle size sorter. The hydrophilic aerosol generating liquid generates a polydisperse hydrophilic aerosol through the polydisperse aerosol generator, and the polydisperse hydrophilic aerosol is screened by the aerosol particle size sorter to obtain first monodisperse hydrophilic aerosols with different particle sizes.

[0035] In one embodiment, the first monodisperse hydrophilic aerosols with different particle sizes are monodisperse hydrophilic aerosols with particle sizes less than or equal to 3 μm and different particle sizes.

[0036] In one embodiment, the particle size of the first monodisperse hydrophilic aerosol is 25 nm - 3 μm.

[0037] S103: In one embodiment, the aerosol generator further includes a monodisperse aerosol generator. The monodisperse aerosol generator and the polydisperse aerosol generator are such that the hydrophilic aerosol generating liquid passes through the monodisperse aerosol generator to obtain a second monodisperse hydrophilic aerosol.

[0038] In one embodiment, the second monodisperse aerosol is a monodisperse hydrophilic aerosol with a particle size greater than 3 μm.

[0039] In one embodiment, the aerosol generator further includes a medical nebulizer. The medical nebulizer has a non-interfering parallel relationship with both the polydisperse aerosol generator and the monodisperse aerosol generator. The hydrophilic aerosol generating liquid passes through the medical nebulizer to obtain a polydisperse hydrophilic aerosol.

[0040] In a specific embodiment, the generation of monodisperse / polydisperse hydrophilic aerosols is as Figure 5 shown. After the air compressor compresses the air, the clean air is obtained through cascade filtration. The clean air enters different channels through valve control for aerosol generation. Among them, there are three types of channels. The first type consists of a polydisperse aerosol generator and an aerodynamic aerosol particle size sorter for generating monodisperse aerosols with particle sizes less than or equal to 3 microns. The second type consists of a flow-aggregation monodisperse aerosol generator for generating monodisperse aerosols with particle sizes greater than 3 microns. The third type consists of an air-compressed medical nebulizer for generating polydisperse aerosols. In the first type, there is a glucose radioactive aerosol generating liquid with a single particle size for obtaining an aerosol with a single particle size. In the first and second types, there are glucose radioactive aerosol generating liquids with different concentrations for obtaining aerosols with different particle sizes and different numbers of particle sizes.

[0041] In a specific embodiment, the process of aerosol generation and human inhalation: Experimental equipment: Human lung deposition quantification device (Huironghe Technology Co., Ltd.), TSI 3321 Aerodynamic Particle Sizer, TSI Scanning Mobility Particle Sizer (TSI 3756, TSI 3081A, TSI 3082, TSI 3088), cascade filter (Huironghe Technology Co., Ltd.), flowmeter (Huironghe Technology Co., Ltd.), valve (Huironghe Technology Co., Ltd.), air pump (Huironghe Technology Co., Ltd.), human SPECT / CT (Siemens, Germany), filter membrane sampler (Huironghe Technology Co., Ltd.), negative pressure suction device (Siyamei Technology Co., Ltd.).

[0042] First, make radioactive glucose into monodisperse aerosol and introduce it into the nose and mouth exposure tower to construct a stable gas environment (monitor the aerosol particle size spectrum using the TSI 3321 Aerodynamic Particle Sizer and the TSI Scanning Mobility Particle Sizer).

[0043] In a specific embodiment, it is shown through the aerosol particle size spectrum that, as Figure 6 shown, the aerosol particle size spectrum diagram shows that the aerosol particle size spectra of 0.7 μm and 3 μm have good concentration, GSD < 1.2, meeting the monodisperse condition.

[0044] In a specific embodiment, the present invention first uses the radioactive isotope 18 F-FDG to construct a radioactive glucose solution by relying on the miscibility principle to label soluble glucose ( 18 F-FDG + glucose). Subsequently, use the Collision three-hole polydisperse aerosol generator combined with the aerodynamic aerosol particle size separator and the flow focusing monodisperse aerosol generator to generate monodisperse radioactive aerosol in the micro-nano wide scale (25 nm - 10 μm), use the air compression medical nebulizer to generate polydisperse aerosol, then use the first-invented human lung deposition quantification device combined with the tail gas recovery system to conduct human inhalation exposure to radioactive aerosol, and finally perform high-resolution PET / CT detection and quantification of the deposition distribution on the inhaled human body.

[0045] The disclosed embodiment of the present invention also provides a computer program product or system, including a computer program, which when executed by a processor implements the steps of the above method for generating different particle size hydrophilic monodisperse aerosol for human inhalation.

[0046] Figure 2 The schematic diagram of the system for generating different particle size hydrophilic monodisperse aerosol for human inhalation provided by the embodiment of the present invention specifically includes: Acquisition unit: Acquire hydrophilic aerosol generating liquid; Generating unit: the hydrophilic aerosol generating liquid is transported into an aerosol generator to obtain a first monodisperse hydrophilic aerosol; the aerosol generator comprises a polydisperse aerosol generator and an aerosol particle size sorter; the hydrophilic aerosol generating liquid is passed through the polydisperse aerosol generator to generate a polydisperse hydrophilic aerosol; the polydisperse hydrophilic aerosol is screened through the aerosol particle size sorter to obtain first monodisperse hydrophilic aerosols of different particle sizes.

[0047] Figure 3 A schematic diagram of a device for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation provided in an embodiment of the present invention specifically includes: A memory and a processor; the memory is used to store program instructions; the processor is used to call program instructions, and when the program instructions are executed, any one of the above-mentioned methods for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation is performed.

[0048] The disclosed embodiments of the present invention also provide a computer-readable storage medium storing a computer program, which, when executed by a processor, performs any of the above-mentioned methods for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation.

[0049] An embodiment of the present invention provides a method for generating a deposition distribution diagram of a hydrophilic aerosol in the respiratory tract, comprising: According to the above-mentioned method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, a radioactive hydrophilic aerosol is obtained, wherein the hydrophilic aerosol includes one or more of the following: a first monodisperse hydrophilic aerosol, a second monodisperse hydrophilic aerosol, and a polydisperse hydrophilic aerosol; After the subject inhales the hydrophilic aerosol, a respiratory tract of the subject is scanned to obtain image data of the subject; A deposition distribution diagram of the hydrophilic aerosol in the respiratory tract is obtained based on the image data of the subject.

[0050] In one embodiment, the method further comprises tail gas recovery, and after the subject inhales the hydrophilic aerosol from the inhalation tower, the radioactive hydrophilic aerosol remaining in the inhalation tower and the exhalation tower is recovered.

[0051] In a specific embodiment, the human mouth is exposed to breathing for 15 minutes. After the exposure, PET / CT is used to quantify the distribution of particle deposition in the human lung. After the experiment, clean air is passed into the inhalation tower and the exhalation tower, and the remaining exhaust gas is recovered as follows Figure 7 shown.

[0052] In a specific embodiment, the quantitative results of PET-CT show that it can quantify the deposition and distribution of radioactive glucose particles in the respiratory tract with high resolution, such as Figure 8as shown

[0053] The disclosed embodiments of the present invention also provide a computer program product or system, including a computer program, which when executed by a processor implements the steps of the above-mentioned method for quantitatively determining the deposition distribution of hydrophilic aerosol in the respiratory tract.

[0054] The system for quantitatively determining the deposition distribution of hydrophilic aerosol in the respiratory tract provided by the embodiments of the present invention specifically includes: Acquisition module: obtaining a radioactive hydrophilic aerosol according to the above-mentioned method for generating hydrophilic monodisperse aerosols with different particle sizes for human inhalation, where the hydrophilic aerosol includes one or more of the following: first monodisperse hydrophilic aerosol, second monodisperse hydrophilic aerosol, polydisperse hydrophilic aerosol; Imaging module: performing tomographic scanning on the respiratory tract of the subject after the subject inhales the hydrophilic aerosol to obtain image data of the subject; Deposition module: obtaining a deposition distribution map of the hydrophilic aerosol in the respiratory tract based on the image data of the subject.

[0055] The equipment for quantitatively determining the deposition distribution of hydrophilic aerosol in the respiratory tract provided by the embodiments of the present invention specifically includes: A memory and a processor; the memory is used for storing program instructions; the processor is used for calling the program instructions, and when the program instructions are executed, any one of the above-mentioned methods for quantitatively determining the deposition distribution of hydrophilic aerosol in the respiratory tract.

[0056] The disclosed embodiments of the present invention also provide a computer-readable storage medium, which stores a computer program, and when the computer program is executed by a processor, any one of the above-mentioned methods for quantitatively determining the deposition distribution of hydrophilic aerosol in the respiratory tract.

[0057] The embodiments of the present invention provide a method for constructing a prediction model for the deposition distribution of hydrophilic particles, including: Obtaining a deposition distribution data set of the subject according to the above-mentioned method for quantitatively determining the deposition distribution of hydrophilic aerosol in the respiratory tract, with hydrophilic aerosols of different particle sizes as labels; Inputting the data set and labels into a neural network for training until the loss function remains unchanged to obtain a deposition prediction model.

[0058] The disclosed embodiments of the present invention also provide a computer program product or system, including a computer program, which when executed by a processor implements the steps of the above-mentioned method for constructing a prediction model for the deposition distribution of hydrophilic particles.

[0059] The system for constructing a prediction model for the deposition distribution of hydrophilic particles provided by the embodiments of the present invention specifically includes: Particle size module: Obtain the deposition distribution dataset of the subject according to the above method for generating the deposition distribution map of hydrophilic aerosol in the respiratory tract, and hydrophilic aerosols of different particle sizes are used as labels; Construction module: Input the dataset and labels into a neural network for training until the loss function remains unchanged to obtain a deposition prediction model.

[0060] In one embodiment, the neural network adopts one or several of the following: convolutional neural network, dilated convolutional neural network, residual network, Transformer.

[0061] The prediction model construction device for the deposition distribution of hydrophilic particles provided by the embodiments of the present invention specifically includes: A memory and a processor; the memory is used to store program instructions; the processor is used to call the program instructions, and when the program instructions are executed, any of the above methods for constructing the prediction model of the deposition distribution of hydrophilic particles.

[0062] The disclosed embodiments of the present invention also provide a computer-readable storage medium, which stores a computer program, and when the computer program is executed by a processor, any of the above methods for constructing the prediction model of the deposition distribution of hydrophilic particles.

[0063] The embodiments of the present invention provide a prediction method for the deposition distribution of hydrophilic aerosol particles based on different particle sizes, including: Obtain the particle size of the hydrophilic aerosol inhaled by the subject; Input the particle size into the deposition prediction model obtained by the above method for constructing the prediction model of the deposition distribution of hydrophilic particles to obtain a deposition distribution prediction map.

[0064] The disclosed embodiments of the present invention also provide a computer program product or system, including a computer program, and when the computer program is executed by a processor, the steps of the above prediction method for the deposition distribution of hydrophilic aerosol particles based on different particle sizes are implemented.

[0065] The prediction system for the deposition distribution of hydrophilic aerosol particles based on different particle sizes provided by the embodiments of the present invention specifically includes: Aerosol unit: Obtain the particle size of the hydrophilic aerosol inhaled by the subject; Prediction unit: Input the particle size into the deposition prediction model obtained by the above method for constructing the prediction model of the deposition distribution of hydrophilic particles to obtain a deposition distribution prediction map.

[0066] The prediction device for the deposition distribution of hydrophilic aerosol particles based on different particle sizes provided by the embodiments of the present invention specifically includes: A memory and a processor; the memory is used for storing program instructions; the processor is used for calling the program instructions, and when the program instructions are executed, any one of the above-mentioned prediction methods based on the deposition distribution of hydrophilic aerosol particles with different particle sizes.

[0067] The disclosed embodiments of the present invention also provide a computer-readable storage medium storing a computer program, and when the computer program is executed by a processor, any one of the above-mentioned prediction methods for the deposition distribution of hydrophilic aerosol particles with different particle sizes.

[0068] The verification results of this verification embodiment show that assigning inherent weights to the indications can improve the performance of the method compared to the default settings. Those skilled in the art can clearly understand that for the convenience and conciseness of description, the specific working processes of the above-described systems, devices, and units can refer to the corresponding processes in the foregoing method embodiments and will not be elaborated herein. In several embodiments provided by the present application, it should be understood that the disclosed systems, devices, and methods can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For example, the division of the units is only a logical function division, and there may be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed couplings or direct couplings or communication connections to each other can be through some interfaces, and the indirect couplings or communication connections of the devices or units can be in electrical, mechanical, or other forms. The units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they can be located in one place or distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment. In addition, in each embodiment of the present invention, the functional units can be integrated into one processing unit, or each unit can exist physically alone, or two or more units can be integrated into one unit. The above-mentioned integrated units can be implemented in the form of hardware or in the form of software functional units. Those of ordinary skill in the art can understand that all or part of the steps in the various methods of the above embodiments can be completed by instructing relevant hardware through a program, and the program can be stored in a computer-readable storage medium. The storage medium can include: read-only memory (ROM, Read Only Memory), random access memory (RAM, Random Access Memory), magnetic disk, or optical disc, etc.

[0069] Those of ordinary skill in the art can understand that all or part of the steps in implementing the methods of the above embodiments can be completed by instructing relevant hardware through a program, and the program can be stored in a computer-readable storage medium. The above-mentioned medium storage can be a read-only memory, a magnetic disk, an optical disk, etc.

[0070] The above provides a detailed introduction to a computer device provided by the present invention. For those of ordinary skill in the art, according to the ideas of the embodiments of the present invention, there will be changes in the specific implementation manners and application scopes. In summary, the content of this specification should not be construed as a limitation on the present invention.

Claims

1. A method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, characterized in that: include: obtaining a hydrophilic aerosol generating liquid; The hydrophilic aerosol generating liquid is transported into an aerosol generator to obtain a first monodisperse hydrophilic aerosol; the aerosol generator includes a polydisperse aerosol generator and an aerosol particle size sorter, the hydrophilic aerosol generating liquid is passed through the polydisperse aerosol generator to generate a polydisperse hydrophilic aerosol, and the polydisperse hydrophilic aerosol is screened through the aerosol particle size sorter to obtain a first monodisperse hydrophilic aerosol with different particle sizes.

2. The method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation according to claim 1, characterized in that: The first monodisperse hydrophilic aerosols of different particle sizes are monodisperse hydrophilic aerosols of different particle sizes less than or equal to 3 μm; Optionally, the aerosol generator further comprises a monodisperse aerosol generator, the monodisperse aerosol generator and the polydisperse aerosol generator are in a parallel relationship without interfering with each other, and the hydrophilic aerosol generating liquid passes through the monodisperse aerosol generator to obtain a second monodisperse hydrophilic aerosol; Optionally, the second monodisperse hydrophilic aerosol is a monodisperse hydrophilic aerosol larger than 3 μm; Optionally, the aerosol generator also includes a medical nebulizer, and the medical nebulizer is in a parallel relationship with the polydisperse aerosol generator and the monodisperse aerosol nebulizer without interfering with each other, and the hydrophilic aerosol generating liquid is passed through the medical nebulizer to obtain a polydisperse hydrophilic aerosol.

3. The method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation according to claim 1, characterized in that: The hydrophilic aerosol generating liquid is a radioactive hydrophilic aerosol generating liquid; the radioactive hydrophilic aerosol generating liquid is transferred into an aerosol generator to obtain a radioactive first monodisperse hydrophilic aerosol; Optionally, the preparation process of the radioactive hydrophilic aerosol generating liquid is: Obtain radioisotopes and hydrophilic particles; adding the radioactive isotope to ultrapure water to obtain a mixed solution; Adding the hydrophilic particles to the mixed solution, shaking it evenly and performing ultrasound to obtain a radioactive hydrophilic aerosol generating liquid; Optionally, the radioisotope comprises 18 F-FDG solution; Optionally, the hydrophilic particles include glucose; Optionally, the ultrasound is performed for 8-12 minutes.

4. A quantitative method for the deposition distribution of hydrophilic aerosol in the respiratory tract, characterized in that: include: According to any one of claims 1 to 3, the method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation obtains a radioactive hydrophilic aerosol, wherein the hydrophilic aerosol comprises one or more of the following: a first monodisperse hydrophilic aerosol, a second monodisperse hydrophilic aerosol, and a polydisperse hydrophilic aerosol; After the subject inhales the hydrophilic aerosol, the respiratory tract of the subject is scanned to obtain imaging data of the subject; A deposition distribution diagram of the hydrophilic aerosol in the respiratory tract is obtained based on the image data of the subject.

5. The quantitative method for the deposition distribution of hydrophilic aerosol in the respiratory tract according to claim 4, characterized in that: The method further comprises tail gas recovery, wherein the subject inhales the hydrophilic aerosol from the inhalation tower and recovers the remaining radioactive hydrophilic aerosol in the inhalation tower and the exhalation tower.

6. A method for constructing a prediction model for hydrophilic particle deposition distribution, characterized in that: include: The quantitative method for the deposition distribution of hydrophilic aerosol in the respiratory tract according to claim 4 obtains a deposition distribution data set of a subject, wherein hydrophilic aerosols of different particle sizes are used as labels; The data set and labels are input into a neural network for training until the loss function remains unchanged to obtain a deposition prediction model.

7. A method for predicting the deposition distribution of hydrophilic aerosol particles of different particle sizes, characterized in that: include: Obtain the particle size of the hydrophilic aerosol inhaled by the subject; The particle size is input into the deposition prediction model obtained by the deposition prediction model construction method based on hydrophilic particle deposition distribution according to claim 6 for prediction to obtain a deposition distribution prediction graph.

8. A computer program product comprising a computer program or instructions, characterized in that: The computer program or instructions are executed by the processor to implement the method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation as described in any one of claims 1 to 3, or to implement the quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract as described in claim 4, or to implement the method for constructing a prediction model for the deposition distribution of hydrophilic particles as described in claim 6, or to implement the method for predicting the deposition distribution of hydrophilic aerosol particles of different particle sizes as described in claim 7.

9. A computer device comprising a memory, a processor and a computer program or instruction stored in the memory, characterized in that: The computer program or instructions are executed by the processor to implement the method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation as described in any one of claims 1 to 3, or to implement the quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract as described in claim 4, or to implement the method for constructing a prediction model for the deposition distribution of hydrophilic particles as described in claim 6, or to implement the method for predicting the deposition distribution of hydrophilic aerosol particles of different particle sizes as described in claim 7.

10. A computer-readable storage medium having a computer program or instruction stored thereon, characterized in that: The computer program or instructions are executed by the processor to implement the method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation as described in any one of claims 1 to 3, or to implement the quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract as described in claim 4, or to implement the method for constructing a prediction model for the deposition distribution of hydrophilic particles as described in claim 6, or to implement the method for predicting the deposition distribution of hydrophilic aerosol particles of different particle sizes as described in claim 7.

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