Sample analyzer and method for detecting use state of kit

Abstract

The invention discloses a sample analyzer and a detection method for the use state of a kit, the sample analyzer comprises a detection seat, a first detection assembly and a control unit, the detection seat forms a containing cavity, the containing cavity is used for containing the kit, and the kit comprises at least one detection channel; the first detection assembly is arranged on the detection seat and is used for detecting a voltage parameter of at least one detection channel of the kit; the control unit is connected with the first detection assembly and is used for acquiring a voltage parameter of at least one detection channel of the kit through the first detection assembly; and determining the use state of the kit based on the voltage parameter of the at least one detection channel of the kit. According to the sample analyzer, the use state of the kit is confirmed, the repeatedly used kit is prevented from entering a test process, the test accuracy of the sample analyzer is improved, and the service life of the sample analyzer is prolonged.

Description

Technical Field

[0001] The present application relates to the technical field of medical equipment, and in particular to a method for detecting the use status of a sample analyzer and a reagent kit. Background Art

[0002] The sample analyzer is a medical precision instrument that can be used to analyze and measure blood samples. In blood test analysis, the sample analyzer generally uses a disposable test kit to test the sample. When the test kit is placed in the sample analyzer and the test begins, negative pressure will be used to remove the air from the microporous sheet to the waste liquid chamber to ensure normal counting.

[0003] However, if the test kit has been used, that is, the test kit to be tested is in a reused state, the waste liquid chamber of the test kit is generally full, and during the process of extracting air, the waste liquid may be drawn into the negative pressure air line, thereby affecting the accuracy of the data detection of the sample analyzer. Summary of the invention

[0004] The present application provides a method for detecting the usage status of a sample analyzer and a reagent kit to solve the technical problem in the prior art that if the reagent kit has been used, waste liquid may be drawn into the negative pressure gas pipeline during the process of extracting air, thereby affecting the accuracy of data detection by the sample analyzer.

[0005] In order to solve the above technical problems, a technical solution adopted by the present application is: to provide a sample analyzer, which includes: a detection seat, a first detection component and a control unit. The detection seat forms a receiving cavity, which is used to receive a reagent kit, wherein the reagent kit includes at least one detection channel; the first detection component is arranged on the detection seat, and is used to detect the voltage parameter of at least one detection channel of the reagent kit; the control unit is connected to the first detection component, and the control unit is used to: obtain the voltage parameter of at least one detection channel of the reagent kit through the first detection component; and determine the use status of the reagent kit based on the voltage parameter of at least one detection channel of the reagent kit.

[0006] Further, the detection channels of the kit include at least one impedance detection channel. A microplate is provided in each impedance detection channel, and micropores are provided on the microplate. The first detection component includes at least one impedance detection unit, and each impedance detection unit is used to perform impedance detection on the corresponding impedance detection channel. The control unit is used to: detect the voltage across the micropores in the corresponding impedance detection channel through at least one impedance detection unit to obtain the voltage parameters of at least one impedance detection channel, and / or, the detection channels of the kit include at least one optical detection channel. The first detection component includes at least one optocoupler unit, and the optocoupler unit is used to perform optical detection on the corresponding optical detection channel. The control unit is further used to: perform optical detection on the corresponding optical detection channel through at least one optocoupler unit to obtain the voltage parameters of at least one optical detection channel.

[0007] Further, the control unit is further used to: detect the voltage across the micropores in the corresponding impedance detection channel through at least one impedance detection unit to obtain the voltage parameters of at least one impedance detection channel; when it is confirmed that the voltage parameters of at least one impedance detection channel are greater than the corresponding voltage thresholds, then perform optical detection on the corresponding optical detection channel through at least one optocoupler unit to obtain the voltage parameters of at least one optical detection channel; and determine the usage status of the kit based on the voltage parameters of at least one optical detection channel.

[0008] Further, at least one impedance detection channel includes a white blood cell detection channel and a red blood cell detection channel. The control unit is further used to: obtain the voltage parameters of the white blood cell detection channel and the red blood cell detection channel through at least one impedance detection unit; when it is confirmed that any one of the voltage parameters of the white blood cell detection channel and the red blood cell detection channel is less than the corresponding voltage threshold, then determine that the kit is in a reused state.

[0009] Further, the control unit is further used to: when it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is greater than or equal to a preset number, then determine that the kit is in a reused state.

[0010] Further, the sample analyzer further includes a pipette, and a second detection component is provided on the pipette. The control unit is further used to: when it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is less than the preset number, then determine that the kit is in a non-reused state; detect whether there is a pipette tip in the preset jack of the kit through the second detection component; when it is confirmed that there is no pipette tip in the preset jack of the kit, send a reminder message to indicate to the user to insert a pipette tip into the preset jack.

[0011] Further, the sample analyzer further includes a pipette, and a second detection component is provided on the pipette. The control unit is further configured to: when it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is less than a preset number, detect whether there is a pipette tip in a preset jack of the reagent kit through the second detection component; when it is confirmed that there is no pipette tip in the preset jack of the reagent kit, determine that the reagent kit is in a reused state; when it is determined that there is a pipette tip in the preset jack of the reagent kit, determine that the reagent kit is in a non-reused state.

[0012] Further, the control unit is further configured to: when it is determined that the usage state of the reagent kit is a reused state, send a reminder message and terminate the detection of the reagent kit; when it is confirmed that the usage state of the reagent kit is a non-reused state, perform the next step of detection on the reagent kit.

[0013] Further, the sample analyzer includes at least one optocoupler unit, and the detection channels of the reagent kit include at least one optical detection channel. The optocoupler unit is configured to perform optical detection on the corresponding optical detection channel. The control unit is configured to: determine whether the reagent kit is located at a preset position in the accommodation cavity based on the voltage change detected by at least one optocoupler unit; when it is confirmed that the reagent kit is located at the preset position in the accommodation cavity, perform the step of obtaining the voltage parameters of at least one detection channel of the reagent kit through the first detection component.

[0014] To solve the above technical problems, a technical solution adopted in this application is: to provide a method for detecting the usage state of a reagent kit. Based on the sample analyzer in any of the above embodiments, the detection method includes: obtaining the voltage parameters corresponding to at least one detection channel of the reagent kit through the first detection component; determining the usage state of the reagent kit based on the voltage parameters corresponding to at least one detection channel of the reagent kit.

[0015] Beneficial effects of this application: Different from the prior art, the sample analyzer of this application includes: a detection base, a first detection component, and a control unit. The detection base forms an accommodation cavity for accommodating the reagent kit; the first detection component is provided on the detection base and is configured to detect the voltage parameters of at least one detection channel of the reagent kit; the control unit is connected to the first detection component, and the control unit is configured to: obtain the voltage parameters of at least one detection channel of the reagent kit through the first detection component; determine the usage state of the reagent kit based on the voltage parameters of at least one detection channel of the reagent kit. The sample analyzer of this application can determine the usage state of the reagent kit according to the voltage parameters of the detection channels of the reagent kit. In this way, it can effectively prevent reused reagent kits from entering the test process, thereby avoiding the waste liquid in the reagent kit from entering the instrument pipeline and causing abnormal detection of samples, improving the accuracy of data testing of the sample analyzer, enhancing the stability of the sample analyzer, and extending the service life of the sample analyzer. Description of the Drawings

[0016] The accompanying drawings here are incorporated into the specification and form a part of this specification. These drawings illustrate embodiments consistent with this application and, together with the specification, are used to explain the technical solutions of this application.

[0017] Figure 1 It is a schematic structural diagram of an embodiment of a sample analyzer provided by this application;

[0018] Figure 2 It is a schematic flowchart of an embodiment of a method for detecting the usage state of a kit provided by this application;

[0019] Figure 3 is Figure 2 a schematic flowchart of an embodiment of step S12 in

[0020] Figure 4 It is a schematic flowchart of another embodiment of a method for detecting the usage state of a kit provided by this application. Detailed Embodiments

[0021] To make the above objects, features, and advantages of this application more obvious and understandable, the following will describe in detail the specific embodiments of this application with reference to the accompanying drawings. It can be understood that the specific embodiments described herein are only used to explain this application and are not intended to limit this application. Additionally, it should be noted that for the sake of description, only the parts related to this application rather than all the structures are shown in the accompanying drawings. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of this application.

[0022] The terms "first", "second", etc. in this application are used to distinguish different objects rather than to describe a specific order. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but may optionally further include steps or units not listed, or may optionally further include other steps or units inherent to these processes, methods, products, or devices.

[0023] Referring to "embodiment" in this context means that a specific feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of this application. The phrase appears in various places in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. Those skilled in the art explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.

[0024] The present application provides a sample analyzer, which can confirm the usage status of a reagent kit. Thus, it can effectively prevent the occurrence of the situation where the reagent kit is reused, improve the accuracy and reliability of data testing of the sample analyzer, and extend the service life of the sample analyzer.

[0025] Please refer to Figure 1 as shown Figure 1 It is a schematic structural diagram of an embodiment of the sample analyzer provided by the present application. Specifically, the sample analyzer 10 includes a detection base 11, a first detection component 12, and a control unit 13.

[0026] Among them, the detection base 11 forms a receiving cavity 111 for receiving the reagent kit 20. The sample analyzer 10 detects the sample through the reagent kit 20. The reagent kit 20 is a consumable for single use. Reusing the reagent kit 20 will affect the accuracy of sample detection by the sample analyzer 10 and the service life of the sample analyzer 10.

[0027] The reagent kit 20 includes at least one detection channel. Optionally, the detection channels of the reagent kit 20 may include at least one impedance detection channel. A microplate is provided in the impedance detection channel, and micropores are provided on the microplate. The impedance detection channel is used for impedance detection of the sample. In a specific embodiment, each reagent kit 20 may include a WBC (white blood cell) detection channel and an RBC (red blood cell) detection channel. The WBC detection channel and the RBC detection channel each include a front pool and a rear pool. Each front pool has an open upper part and serves as an inlet for adding reagents and samples. A front pool electrode is installed in the front pool, and a rear pool electrode is installed in the rear pool. One ends of the front pool electrode and the rear pool electrode are exposed on the surface of the pool body to form electrode contact points. A microplate for detecting blood parameters is provided between the front pool and the rear pool; each rear pool is connected to a cavity. The bottom of the cavity is closed, and the upper opening is a pressure jack, which is connected to a negative pressure connection device during measurement. Under the action of negative pressure, the sample in the front pool enters the rear pool through the microplate to count the cells.

[0028] In some other embodiments, the detection channels of each reagent kit 20 may also include at least one optical detection channel for performing transmission light photoelectric detection and / or scattered light photoelectric detection on the sample. For example, each reagent kit 20 may include an HGB (hemoglobin) detection channel for measuring hemoglobin in the sample by a colorimetric method using an optical detection component.

[0029] The first detection component 12 is disposed on the detection base 11 and is used to detect the voltage parameters of the detection channels of the reagent kit 20 in the accommodation cavity 111, so as to obtain the voltage parameters of the detection channels of the reagent kit 20 through the first detection component 12.

[0030] Optionally, the first detection component 12 may include at least one impedance detection unit (not shown in the figure). The impedance detection unit is used to detect the impedance of the impedance detection channel of the reagent kit 20. The control unit 13 of the sample analyzer 10 can obtain the voltage parameters of the impedance detection channel of the reagent kit 20 through the impedance detection unit.

[0031] Optionally, the first detection component 12 may also include at least one optocoupler unit (not shown in the figure). The optocoupler unit is used to perform optical detection on the optical detection channel of the reagent kit 20. The optocoupler unit can convert the acquired optical signal into a voltage signal to obtain the voltage parameters of the optical detection channel. The optocoupler unit may include a light emitter and a light receiver. The light emitter emits an illumination beam, and the illumination beam is transmitted or scattered through the optical detection channel of the reagent kit 20. The light receiver is used to receive the beam exiting from the optical detection channel, and the control unit 13 can obtain the voltage parameters of the optical detection channel through the voltage change of the light receiver.

[0032] The control unit 13 is connected to the first detection component 12 and is used to control the first detection component 12 to detect the detection channels of the reagent kit 20.

[0033] Based on the sample analyzer 10 of any of the above embodiments, the present application further provides a method for detecting the usage status of a reagent kit. Please refer to Figure 2 as shown in Figure 2 FIG. is a schematic flowchart of an embodiment of the method for detecting the usage status of the reagent kit provided by the present application. The detection method includes:

[0034] S11: Obtain the voltage parameters of at least one detection channel of the reagent kit through the first detection component.

[0035] After the reagent kit 20 is placed at a preset position in the accommodation cavity 111, the control unit 13 controls the first detection component 12 to detect at least one detection channel of the reagent kit 20, so as to obtain the voltage parameters of at least one detection channel of the reagent kit 20. Wherein, the preset position of the reagent kit 20 in the accommodation cavity 111 refers to the initial position where the reagent kit 20 can directly start detecting the sample in the reagent kit 20 after being installed in the accommodation cavity 111.

[0036] Specifically, the control unit 13 can control the first detection component 12 to detect the voltage parameters of one detection channel of the test kit 20, so as to simplify the detection steps and improve the detection efficiency. In other embodiments, the control unit 13 can also control the first detection component 12 to detect the voltage parameters of multiple detection channels to obtain the voltage parameters of multiple detection channels and improve the reliability of the detection.

[0037] When the detection channel is an impedance detection channel, the control unit 13 can control the impedance detection unit of the sample analyzer 10 to detect the voltage across the microplate to obtain the voltage parameters of the impedance detection channel. When the detection channel is an optical detection channel, the control unit 13 can obtain the voltage parameters of the optical detection channel through the optocoupler unit of the sample analyzer 10.

[0038] For example, the test kit 20 includes two impedance detection channels and one optical detection channel. The two impedance detection channels are the red blood cell detection channel and the white blood cell detection channel respectively, and the optical detection channel is the HGB detection channel. The control unit 13 can control the first detection component 12 to measure the voltage parameters of the red blood cell detection channel, the white blood cell detection channel and the HGB detection channel, or only detect the voltage parameters of some of the detection channels. Specifically, it can be selected according to the actual situation and is not specifically limited here.

[0039] S12: Determine the usage status of the test kit based on the voltage parameters of at least one detection channel of the test kit.

[0040] After obtaining the voltage parameters of at least one detection channel of the test kit 20, the control unit 13 determines the usage status of the test kit 20 according to the voltage parameters of the at least one detection channel.

[0041] The usage status of the test kit 20 includes a reused status and a non-reused status. Since the test kit 20 is a disposable item, the test kit 20 in the reused status refers to a test kit that has been used, and this test kit 20 is an abnormal test kit. The non-reused test kit 20 refers to a test kit that has not been used, and this test kit 20 is a test kit for normal testing.

[0042] Furthermore, if the test kit 20 is in a reused state, there is waste liquid in the detection channel and its voltage parameter value is low; if the test kit 20 is in a non-reused state, there is no waste liquid in the detection channel and its voltage parameter value is high. Therefore, the control unit 13 can judge whether the voltage value of the detection channel is lower than the corresponding voltage threshold to judge the usage status of the test kit 20.

[0043] In the above embodiments, the usage status of the kit is judged by detecting the voltage parameters of the detection channels. The measurement process of the voltage parameters is simple, no new hardware needs to be added, the cost is low, and the accuracy of this detection method is also relatively high. It can effectively prevent the reused kit 20 from entering the test process, avoid the waste liquid in the kit 20 from entering the instrument pipeline and causing abnormal detection of the sample, improve the accuracy of data testing of the sample analyzer 10, improve the stability of the sample analyzer 10, and extend the service life of the sample analyzer 10.

[0044] Further, as Figure 3 shown, Figure 3 is Figure 2 a schematic flowchart of an embodiment of step S12 in

[0045] S121: When it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is greater than or equal to a preset number, it is determined that the kit is in a reused state.

[0046] The control unit 13 can determine that the kit 20 is in a reused state when it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is greater than or equal to a preset number. The preset number can be 1, 2, 3, or 4, etc. That is, if the voltage parameters of the detection channels above the preset number are abnormal, it is confirmed that the kit 20 has been used.

[0047] For example, as long as there is 1 detection channel among the measured voltage parameters of the detection channels whose voltage parameter is lower than the corresponding voltage threshold, that is, the voltage parameter of one of the detection channels is abnormal, it is confirmed that the kit 20 is a reused kit. By this means, the probability of the reused kit 20 entering the subsequent test process can be reduced, and the reliability of the sample analyzer 10 can be improved. In other embodiments, it can also be determined that the kit 20 is in a reused state when the voltage parameters of at least two detection channels of the kit 20 are lower than the corresponding voltage thresholds. By this means, the accuracy of judging the usage status of the kit 20 can be improved, and the misjudgment of the usage status of the kit 20 can be reduced.

[0048] S122: When it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is less than the preset number, it is determined that the kit is in a non-reused state.

[0049] When the control unit 13 determines that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is less than the preset number, it can determine that the test kit 20 is in a non-reusable state. For example, when the preset number is 1, when the number of detection channels with abnormal voltage parameters is 0, that is, when the voltage parameters of all detection channels are normal, it is confirmed that the test kit 20 is a non-reusable test kit 20. In this way, it is possible to accurately determine the unused test kit 20 and improve the reliability of the sample analyzer 10. In other embodiments, when the voltage parameters of most of the measured detection channels are greater than the corresponding voltage thresholds (for example, the voltage parameters in 50% of the detection channels are greater than the corresponding voltage thresholds), it can be considered that the test kit 20 is in a non-reusable state. In this way, it is possible to avoid misjudging the usage status of the test kit 20 due to measurement errors in a certain detection channel.

[0050] When the control unit 13 determines that the usage status of the test kit 20 is a reusable state, it can send a reminder message to the user, terminate the detection of the test kit 20, and respond to the user's operation instruction to exit the test kit 20. When the control unit 13 determines that the usage status of the test kit 20 is a non-reusable state, the sample analyzer 10 can perform the next detection on the test kit 20, enabling the test kit 20 to be used for sample detection. In this way, it is possible to prevent the reusable test kit 20 from entering the test process, enable the non-reusable test kit 20 to enter the test process normally, with a high degree of intelligence, and improve the reliability of the sample analyzer 10.

[0051] In the above embodiments, the usage status of the test kit 20 is determined according to the number of detection channels with voltage parameters lower than the corresponding voltage thresholds. The judgment process is simple, and it is possible to avoid misjudging the usage status of the test kit 20 due to measurement errors in the voltage parameters of individual detection channels, improve the accuracy of the test kit 20 status detection, and thus improve the stability of the sample analyzer 10.

[0052] Further, since there is a situation where the new kit does not have a pipette placed, for the structure of the pipette on the kit 20, please refer to the description of the following embodiments and will not be elaborated here. The control unit 13 can also be used for: when it is determined that the kit 20 is in a non-reusable state; then, the second detection component 141 (for the description of the second detection component 141, please refer to the description of the following embodiments and will not be elaborated here) is used to detect whether there is a pipette in the preset jack of the kit 20; when it is confirmed that there is no pipette in the preset jack of the kit 20, a reminder message is sent to indicate the user to insert a pipette into the preset jack of the kit 20. In this embodiment, when it is confirmed that the kit 20 is a new kit, the second detection component 14 is used to detect whether a pipette is placed on the kit 20. If there is no pipette on the kit 20, a reminder is sent to the user so that the user can insert the pipette in time to avoid affecting the normal test of the kit 20. In this way, the detection reliability of the sample analyzer 10 can be improved.

[0053] Optionally, the control unit 13 can also obtain the voltage parameters of the white blood cell detection channel and the red blood cell detection channel through the impedance detection unit; when it is confirmed that any one of the voltage parameters of the white blood cell detection channel and the red blood cell detection channel is less than the corresponding voltage threshold, it is determined that the kit 20 is in a reusable state. In this embodiment, only the voltage parameters of the impedance detection channel need to be detected, and the detection process is simple. Moreover, when any one of the voltage parameters of the white blood cell detection channel and the red blood cell detection channel is abnormal, it is confirmed that the kit 20 is in a reusable state. The accuracy of the state detection of the kit 20 is relatively high, which can effectively prevent the reused kit 20 from entering the test process and causing abnormal detection of the sample due to the waste liquid entering the instrument pipeline, thereby improving the stability of the sample analyzer 10.

[0054] Optionally, the control unit 13 can also detect the voltage across the micropores on both sides of the corresponding impedance detection channel through at least one impedance detection unit to obtain the voltage parameters of at least one impedance detection channel; when it is confirmed that the measured voltage parameters of the impedance detection channels are all greater than the corresponding voltage thresholds, at least one optocoupler unit is used to perform optical detection on the corresponding optical detection channels to obtain the voltage parameters of at least one optical detection channel; based on the voltage parameters of at least one optical detection channel, the usage state of the kit 20 is determined. That is, the control unit 13 first makes a preliminary judgment on the usage state of the kit 20 through the impedance detection channel. When the voltage parameters in the impedance detection channel are normal, the voltage parameters of the optical detection channel are used to further confirm the usage state of the kit 20. In this way, the usage state of the kit 20 can be determined more accurately.

[0055] In other embodiments, the usage status of the reagent kit 20 can be initially judged by detecting the voltage parameters of the detection channel, and then the corresponding position of the reagent kit 20 is detected to determine whether there is a nozzle, so as to perform a second confirmation of the usage status of the reagent kit 20. In this way, the accuracy of the judgment of the usage status of the reagent kit 20 can be further improved.

[0056] like Figure 4 As shown, Figure 4 : is a flow chart of another embodiment of a method for detecting the use status of a kit provided in the present application, the detection method comprising:

[0057] S21: Determine whether the reagent kit is located at a preset position of the accommodating cavity through a voltage change of a light receiver of at least one optical coupling unit.

[0058] After the reagent box 20 is placed in the receiving chamber 111, the control unit 13 can determine whether the reagent box 20 is placed in the preset position through the optical coupling unit of the sample analyzer 10. The preset position of the reagent box 20 in the receiving chamber 111 refers to the initial position where the reagent box 20 is located in the receiving chamber 111 and the sample analyzer 10 can directly start to detect the sample in the reagent box 20.

[0059] Specifically, the optical coupling unit includes an optical transmitter and an optical receiver, the optical transmitter is used to emit an illumination light beam, the illumination light beam is emitted to the optical detection channel, the optical receiver is used to receive the light beam emitted by the optical detection channel, and the control unit 13 confirms whether the reagent kit 20 is placed in a preset position according to the voltage change of the optical receiver. The optical coupling unit can be used to perform HGB detection on the sample. In other embodiments, the optical coupling unit can also be used to detect other items on the sample. In this way, the installation position of the reagent kit 20 can be confirmed by using the optical coupling unit of the sample analyzer 10, the process is simple, and the cost is low.

[0060] S22: When it is confirmed that the reagent kit is located at a preset position in the accommodating chamber, a voltage parameter of at least one detection channel of the reagent kit is obtained through a first detection component.

[0061] Step S32 is the same as step S11 and will not be described again.

[0062] S23: When it is confirmed that the number of detection channels whose voltage parameters are lower than the corresponding voltage threshold is greater than or equal to a preset number, it is determined that the reagent kit is in a state of being reused.

[0063] Step S23 is the same as step S121 and will not be described again here.

[0064] S24: When it is confirmed that the number of detection channels whose voltage parameters are lower than the corresponding voltage threshold is less than a preset number, a second detection component is used to detect whether there is a nozzle in a preset socket of the reagent kit.

[0065] When the control unit 13 confirms that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is less than the preset number, it can be preliminarily confirmed that the kit is in a non-reusable state. Then, the second detection component 141 is used to detect whether there is a pipette tip (not shown in the figure) in the preset jack of the kit 20 to perform a secondary confirmation of the usage state of the kit 20.

[0066] Since the loading position of the pipette tip during the test of the kit 20 is the jack at a certain position of the kit, the pipette tip is inserted into the preset jack of the kit 20 before use. During the use of the kit 20, the pipette 14 of the sample analyzer 10 will assemble the pipette tip in the preset jack and then perform the work of each link of the sample analysis. And after the sample analysis work is completed, the pipette 14 will transfer the pipette tip to other empty positions of the kit 20 except the preset jack. Therefore, in the used kit 20, there is usually no pipette tip in the jack for accommodating the pipette tip. Therefore, if the user misoperates and uses a reusable kit 20, the pipette 14 cannot assemble the pipette tip in the preset jack of the kit 20. If the kit 20 is a non-reusable kit, the pipette 14 can assemble the pipette tip in the preset jack.

[0067] In some specific embodiments, the second detection component 141 can be provided on the pipette 14. When the loading head of the pipette 14 presses down to assemble the pipette tip, the second detection component 141 is used to detect whether there is a pipette tip at the preset position of the kit 20.

[0068] The second detection component 141 can include an optocoupler and an optocoupler baffle. A sleeve (not shown in the figure) can be provided on the outside of the loading head of the pipette 14, and the sleeve can move up and down relative to the loading head under the action of an external force. The optocoupler baffle can be fixed to the sleeve, and the optocoupler is fixed to the pipette 14. When the loading head moves down, if there is a pipette tip at the preset jack, the optocoupler baffle will move up to cover the optocoupler sensor to detect whether there is a pipette tip in the preset jack of the kit 20.

[0069] S25: When it is determined that there is a pipette tip in the preset jack of the kit, it is determined that the kit is in a non-reusable state.

[0070] When the control unit 13 confirms that there is a pipette tip at the preset jack of the kit 20, it can be considered that the kit 20 has not been used. Therefore, it is determined that the kit 20 is in a non-reusable state, and the sample analyzer 10 can perform the next test on the kit 20.

[0071] S26: When it is confirmed that there is no pipette tip in the preset jack of the kit, it is determined that the kit is in a reusable state.

[0072] When the control unit 13 confirms that there is no pipette tip at the preset jack of the kit 20, it can be considered that the kit 20 has been used, and the kit 20 is determined to be in a reused state. The test program of the sample analyzer 10 for the kit 20 is terminated, and a reminder is sent to the user, improving the accuracy of the test data of the sample analyzer 10 and extending the service life of the sample analyzer 10.

[0073] In the above embodiment, the voltage parameter of the detection channel of the kit 20 is first obtained, and the usage status of the kit 20 is preliminarily judged according to the voltage parameter of the detection channel. When it is confirmed that the kit 20 may be a non-reusable kit, the second detection component 141 is used to detect whether there is a pipette tip in the preset jack of the kit 20 to reconfirm the usage status of the kit 20. In this way, when judging the usage status of the kit 20 through the voltage parameter, when there is interference or accidental failure of some components, the usage status of the kit 20 can be further confirmed, thereby further improving the accuracy of the status detection of the kit 20.

[0074] In summary, the sample analyzer 10 of the present application can reduce the probability of reused kits 20 entering the test program; effectively prevent the waste liquid in the kit 20 from entering the instrument and causing pollution to the sample analyzer 10, improve the accuracy of data detection and the stability of performance of the sample analyzer 10, and extend the service life of the sample analyzer 10.

[0075] The above are only the embodiments of the present application, and do not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made by using the content of the specification and drawings of the present application, or directly or indirectly applied in other related technical fields, shall be equally included in the patent protection scope of the present application.

Claims

1. A sample analyzer, characterized in that, the sample analyzer includes: a detection seat, the detection seat forms a receiving cavity, and the receiving cavity is used for receiving a reagent kit, wherein the reagent kit includes at least one detection channel; a first detection component, arranged on the detection seat, for detecting voltage parameters of at least one of the detection channels of the reagent kit; a control unit, connected to the first detection component, and the control unit is used for: acquiring voltage parameters of at least one of the detection channels of the reagent kit through the first detection component; determining the usage status of the reagent kit based on the voltage parameters of at least one of the detection channels of the reagent kit.

2. The sample analyzer according to claim 1, characterized in that, the detection channels of the reagent kit include at least one impedance detection channel, a microplate is arranged in each impedance detection channel, micropores are arranged on the microplate, the first detection component includes at least one impedance detection unit, and each impedance detection unit is used for performing impedance detection on the corresponding impedance detection channel, and the control unit is used for: detecting the voltage across the micropores in the corresponding impedance detection channel through at least one of the impedance detection units to obtain voltage parameters of at least one of the impedance detection channels, and / or, the detection channels of the reagent kit include at least one optical detection channel, the first detection component includes at least one optocoupler unit, and the optocoupler unit is used for performing optical detection on the corresponding optical detection channel, and the control unit is further used for: performing optical detection on the corresponding optical detection channel through at least one of the optocoupler units to obtain voltage parameters of at least one of the optical detection channels.

3. The sample analyzer according to claim 2, characterized in that, the control unit is further used for: detecting the voltage across the micropores in the corresponding impedance detection channel through at least one of the impedance detection units to obtain voltage parameters of at least one impedance detection channel; when it is confirmed that the voltage parameters of at least one of the impedance detection channels are greater than the corresponding voltage thresholds, then performing optical detection on the corresponding optical detection channel through at least one of the optocoupler units to obtain voltage parameters of at least one optical detection channel; determining the usage status of the reagent kit based on the voltage parameters of at least one of the optical detection channels.

4. The sample analyzer according to claim 2, characterized in that, the at least one impedance detection channel includes a white blood cell detection channel and a red blood cell detection channel, and the control unit is further used for: acquiring the voltage parameters of the white blood cell detection channel and the red blood cell detection channel through the at least one impedance detection unit; when it is confirmed that any one of the voltage parameters of the white blood cell detection channel and the red blood cell detection channel is less than the corresponding voltage threshold, then determining that the reagent kit is in a reused state.

5. The sample analyzer according to claim 1, characterized in that, the control unit is further used for: when it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is greater than or equal to a preset number, then determining that the reagent kit is in a reused state.

6. The sample analyzer according to claim 5, wherein, the sample analyzer further includes a pipette, a second detection component is provided on the pipette, and the control unit is further configured to: when it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is less than the preset number, determine that the kit is in a non-reusable state; detect whether there is a pipette tip in the preset jack of the kit through the second detection component; when it is confirmed that there is no pipette tip in the preset jack of the kit, send a reminder message to instruct the user to insert a pipette tip into the preset jack.

7. The sample analyzer according to claim 5, wherein, the sample analyzer further includes a pipette, a second detection component is provided on the pipette, and the control unit is further configured to: when it is confirmed that the number of detection channels with voltage parameters lower than the corresponding voltage thresholds is less than the preset number, detect whether there is a pipette tip in the preset jack of the kit through the second detection component; when it is confirmed that there is no pipette tip in the preset jack of the kit, determine that the kit is in a reusable state; when it is determined that there is a pipette tip in the preset jack of the kit, determine that the kit is in a non-reusable state.

8. The sample analyzer according to claim 7, wherein, the control unit is further configured to: when it is determined that the usage state of the kit is a reusable state, send a reminder message and terminate the detection of the kit; when it is confirmed that the usage state of the kit is a non-reusable state, perform the next step of detection on the kit.

9. The sample analyzer according to claim 1, wherein, the sample analyzer includes at least one optocoupler unit, at least one of the detection channels of the kit includes an optical detection channel, the optocoupler unit is used to perform optical detection on the corresponding optical detection channel, and the control unit is used to: determine whether the kit is located at a preset position in the accommodation cavity based on the voltage change detected by at least one of the optocoupler units; when it is confirmed that the kit is located at the preset position in the accommodation cavity, perform the step of obtaining the voltage parameters of at least one of the detection channels of the kit through the first detection component.

10. A method for detecting the usage state of a kit, wherein, based on the sample analyzer according to any one of claims 1-9, the detection method includes: obtaining the voltage parameters corresponding to at least one of the detection channels of the kit through the first detection component; determining the usage state of the kit based on the voltage parameters corresponding to at least one of the detection channels of the kit.

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