Skin care composition containing animal thymus extract as well as preparation method and application of skin care composition

Abstract

The invention belongs to the technical field of skin care products, and particularly relates to a skin care composition containing animal thymus extract as well as a preparation method and application of the skin care composition. The skin care composition provided by the invention comprises 8.5%-12% of a humectant, 0.01%-0.05% of a chelating agent, 2%-2.3% of a thickening agent, 3%-4% of an emulsifier, 10%-16% of an emollient, 0.5%-0.6% of an antioxidant, 14%-22% of a skin conditioner, 0.2%-0.25% of a pH regulator, 0.6%-0.8% of a preservative, 0.1%-0.2% of an aromatic and the balance of water. According to the invention, the synergistic interaction of the skincare functional components in the skincare composition is realized; meanwhile, through matching assistance, a skin care composition product which is uniform in composition, good in permeability and stable in skin care performance can be obtained. The skin care composition provided by the invention has moisturizing, anti-wrinkle, soothing and repairing effects at the same time, and can be used as a night cream cosmetic.

Description

Technical Field

[0001] The present invention belongs to the technical field of skin care products, and particularly relates to a skin care composition containing animal thymus extract, a preparation method thereof and an application thereof. Background Art

[0002] With the increase of age, the skin ages, its moisturizing effect and barrier function gradually weaken, and the content of natural moisturizing factors decreases; the physiological aging of the skin, the long-term contraction of muscles and the long-term lack of water in the skin will greatly accelerate the generation of fine lines and wrinkles.

[0003] In skin care and beauty products, facial cream is the most important step in basic skin care. If the effective ingredients such as whitening, anti-aging and anti-wrinkle in the facial cream can be effectively absorbed by the skin, they can directly act on facial cells, stimulate the new energy of facial cells, promote the synthesis of collagen at the same time, improve the texture of the skin surface and the skin color uniformity, and make the skin more delicate.

[0004] In recent years, anti-wrinkle, soothing, repairing and moisturizing skin care products have become the core demands of consumers over 25 years old. However, most of the current commercially available cosmetics have the effects of whitening and anti-wrinkle, or are cosmetics with a single performance, and there are very few cosmetics that can simultaneously achieve the effects of anti-wrinkle, soothing, repairing and moisturizing. Summary of the Invention

[0005] The purpose of the present invention is to provide a skin care composition containing animal thymus extract, a preparation method thereof and an application thereof. The skin care composition containing animal thymus extract provided by the present invention has the effects of moisturizing, anti-wrinkle, soothing and repairing, and can be used as a night cream cosmetic.

[0006] In order to achieve the above purpose, the present invention provides the following technical solutions:

[0007] The present invention provides a skin care composition containing animal thymus extract, comprising the following components in mass percentage:

[0008] Humectant 8.5 - 12%, chelating agent 0.01 - 0.05%, thickening agent 2 - 2.3%, emulsifier 3 - 4%, emollient 10 - 16%, antioxidant 0.5 - 0.6%, skin conditioner 14 - 22%, pH regulator 0.2 - 0.25%, preservative 0.6 - 0.8%, fragrance 0.1 - 0.2%, and the balance is water;

[0009] The humectant includes glycerol, glycerol polyacrylate, propylene glycol and hydrogenated polyisobutene;

[0010] The emollient includes lysophosphatidylcholine, scleroglucan, xanthan gum, pullulan, macadamia nut oil, hydrogenated macadamia nut oil, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter, polydimethylsiloxane, and cetearyl dimethicone crosspolymer;

[0011] The skin conditioner includes caprylic / capric triglyceride, centaurea cyanus extract, rosemary leaf oil, animal thymus extract, ginseng root extract, asiatic pennywort extract, and dipotassium glycyrrhizate.

[0012] Preferably, the humectant includes Hispagel 200, glycerin, propylene glycol, and hydrogenated polyisobutene; the mass percentage contents of the components of the humectant in the skin care composition are: Hispagel 200 1.5 - 2%, glycerin 3 - 4%, propylene glycol 3 - 4%, and hydrogenated polyisobutene 1 - 2%.

[0013] Preferably, the emollient includes Ecogel TM , macadamia nut oil, hydrogenated macadamia nut oil, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter, polydimethylsiloxane, and cetearyl dimethicone crosspolymer; the mass percentage contents of the components of the emollient in the skin care composition are: Ecogel TM 0.25 - 0.3%, macadamia nut oil 0.7 - 1.4%, hydrogenated macadamia nut oil 0.3 - 0.6%, ethylhexyl palmitate 2 - 3%, caprylic / capric triglyceride 2 - 3%, shea butter 2 - 3%, polydimethylsiloxane 0.82 - 1.64%, and cetearyl dimethicone crosspolymer 0.18 - 0.36%.

[0014] Preferably, the mass percentage contents of the components of the skin conditioner in the skin care composition are: caprylic / capric triglyceride 2.5 - 3%, centaurea cyanus extract 0.06 - 0.1%, rosemary leaf oil 0.01 - 0.03%, animal thymus extract 6 - 10%, ginseng root extract 3 - 5%, asiatic pennywort extract 2.5 - 3.5%, and dipotassium glycyrrhizate 0.1 - 0.2%.

[0015] Preferably, the emulsifier includes C12 - 16 alcohol, hydrogenated lecithin, palmitic acid, glyceryl stearate, PEG - 100 stearate, polyacrylamide, water, C13 - 14 isoparaffin, and laureth - 7.

[0016] Preferably, the emulsifier includes Biophilic TM H, SIMULSOL 165, and SEPIGEL 305; the mass percentage contents of the components of the emulsifier in the skin care composition are: Biophilic TMH 1.4 - 1.5%, SIMULSOL 165 1.8 - 2% and SEPIGEL 305 0.4 - 0.5%.

[0017] Preferably, the chelating agent is disodium EDTA;

[0018] The thickener includes acrylic (ester) / C10 - 30 alkyl acrylate cross - linked polymer and / or cetearyl alcohol;

[0019] The antioxidant includes p - hydroxyacetophenone;

[0020] The pH regulator is triethanolamine;

[0021] The preservative includes phenoxyethanol and ethylhexylglycerin;

[0022] The fragrance is essence.

[0023] The present invention provides a preparation method of a skin - care composition containing animal thymus extract according to the above - mentioned technical solution, comprising the following steps:

[0024] Mix the components constituting the skin - care composition containing animal thymus extract to obtain the skin - care composition containing animal thymus extract.

[0025] Preferably, the mixing includes the following steps:

[0026] Perform the first mixing on phase A, phase B and phase C to obtain a first mixture. The temperature of the first mixing is 80 - 85 °C. Phase A is water, the first part of the humectant, the chelating agent and part of the thickener. Phase B is the first part of the emulsifier, part of the emollient, the second part of the humectant and the antioxidant. Phase C is the remaining thickener, the second part of the emulsifier, the remaining emollient, the remaining humectant and part of the skin conditioner;

[0027] Perform the second mixing on the first mixture, phase D, phase E and phase F to obtain a second mixture. The temperature of the second mixing is 50 - 55 °C. Phase D is the pH regulator, phase E is the remaining emulsifier, and phase F is the preservative;

[0028] Perform the third mixing on the second mixture, phase G and phase H to obtain the skin - care composition. The temperature of the third mixing is 40 - 45 °C. Phase G is the remaining skin conditioner, and phase H is the fragrance.

[0029] The present invention provides the application of the skin - care composition containing animal thymus extract according to the above - mentioned technical solution or the skin - care composition containing animal thymus extract prepared by the preparation method according to the above - mentioned technical solution in cosmetics, and the cosmetics have one or more of the effects of moisturizing, anti - wrinkle, soothing and repairing.

[0030] The present invention provides a skin care composition containing animal thymus extract, which comprises the following components in mass percentage: humectant 8.5 - 12%, chelating agent 0.01 - 0.05%, thickening agent 2 - 2.3%, emulsifier 3 - 4%, emollient 10 - 16%, antioxidant 0.5 - 0.6%, skin conditioner 14 - 22%, pH regulator 0.2 - 0.25%, preservative 0.6 - 0.8%, fragrance 0.1 - 0.2%, and the balance is water; the humectant includes glycerol, glycerol polyacrylate, propylene glycol and hydrogenated polyisobutene; the emollient includes lysophosphatidylcholine, sclerotium gum, xanthan gum, pullulan, macadamia nut oil, hydrogenated macadamia nut oil, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter, polydimethylsiloxane and cetearyl dimethicone crosslinked polymer; the skin conditioner includes caprylic / capric triglyceride, centaurea cyanus extract, rosemary leaf oil, animal thymus extract, ginseng root extract, asiatic pennywort extract and dipotassium glycyrrhizinate. The skin care composition provided by the present invention realizes the synergistic effect of the skin care functional components in the skin care composition by optimizing the types of the humectant, emollient and skin conditioner; at the same time, with the assistance of the chelating agent, thickening agent, emulsifier, antioxidant, pH regulator, preservative and fragrance, a skin care composition product with uniform composition, good permeability and stable skin care performance can be obtained. As can be seen from the results of the examples, the skin care composition provided by the present invention evaluates its moisturizing performance by means of laboratory tests, and evaluates the anti-wrinkle, soothing and repairing abilities of the skin care composition provided by the present invention through human efficacy evaluation experiments and self-evaluation by the subjects. The results show that the moisturizing effect of the skin care composition provided by the present invention is significantly higher than that of the blank group. After the subjects use the skin care composition provided by the present invention, the fine lines on the face, forehead, eye area and nasolabial folds are reduced, and the redness area becomes smaller, indicating its anti-wrinkle and soothing effects; according to the self-evaluation of the subjects after use, after using the skin care composition provided by the present invention, there are changes in pore refinement, skin hydration and enhanced skin barrier. It shows that the skin care composition provided by the present invention is a cosmetic with moisturizing, anti-wrinkle, soothing and repairing effects. Description of the Drawings

[0031] Figure 1 It is a diagram of the dynamic drying result of the thymopeptide skin care product provided by the example;

[0032] Figure 2 It is a diagram of the wrinkle test result of the Metis skin detector;

[0033] Figure 3 It is a facial texture analysis diagram;

[0034] Figure 4 It is a polarized light diagram. Detailed Embodiments

[0035] The present invention provides a skin care composition containing animal thymus extract, comprising components in the following mass percentages:

[0036] Humectant 8.5 - 12%, chelating agent 0.01 - 0.05%, thickening agent 2 - 2.3%, emulsifier 3 - 4%, emollient 10 - 16%, antioxidant 0.5 - 0.6%, skin conditioner 14 - 22%, pH regulator 0.2 - 0.25%, preservative 0.6 - 0.8%, fragrance 0.1 - 0.2%, and the balance is water;

[0037] The humectant includes glyceryl polyacrylate, glycerin, propylene glycol, and hydrogenated polyisobutene;

[0038] The emollient includes lysophosphatidylcholine, sclerotium gum, xanthan gum, pullulan, macadamia nut oil, hydrogenated macadamia nut oil, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter, polydimethylsiloxane, and cetearyl dimethicone crosspolymer;

[0039] The skin conditioner includes caprylic / capric triglyceride, centaurea cyanus extract, rosemary leaf oil, animal thymus extract, ginseng root extract, centella asiatica extract, and dipotassium glycyrrhizinate.

[0040] In the present invention, unless otherwise specified, all preparation raw materials / components are commercially available products well-known to those skilled in the art.

[0041] Calculated by mass percentage, the skin care composition provided by the present invention includes 8.5 - 12% of humectant, preferably 9 - 11%, and more preferably 9.5 - 10%. In the present invention, the humectant includes glyceryl polyacrylate, glycerin, propylene glycol, and hydrogenated polyisobutene. In a specific embodiment of the present invention, the humectant preferably includes Hispagel 200, glycerin, propylene glycol, and hydrogenated polyisobutene. Hispagel 200 includes glycerin, glyceryl polyacrylate, and water. In Hispagel 200: the mass percentage of glycerin is preferably 45%, the mass percentage of glyceryl polyacrylate is preferably 5%, and the mass percentage of water is preferably 50%. The mass percentages of the components of the humectant in the skin care composition are preferably: Hispagel 200 1.5 - 2%, glycerin 3 - 4%, propylene glycol 3 - 4%, and hydrogenated polyisobutene 1 - 2%; more preferably, Hispagel 200 1.5%, glycerin 3%, propylene glycol 3%, and hydrogenated polyisobutene 2%.

[0042] Calculated by mass percentage, the skin care composition provided by the present invention includes 0.01 - 0.05% of chelating agent, specifically 0.05% in the examples. In the present invention, the chelating agent is preferably disodium EDTA.

[0043] In terms of mass percentage, the skin care composition provided by the present invention comprises 2-2.3% of a thickener, specifically 2.25% in the examples. In the present invention, the thickener preferably comprises acrylate / C10-30 alkanol acrylate cross-linked polymer and / or cetearyl alcohol, specifically acrylate / C10-30 alkanol acrylate cross-linked polymer and cetearyl alcohol in the examples. The mass percentage of each component of the thickener in the skin care composition is preferably: 0.2-0.3% of acrylate / C10-30 alkanol acrylate cross-linked polymer and 1.8-2% of cetearyl alcohol, specifically 0.25% of acrylate / C10-30 alkanol acrylate cross-linked polymer and 2% of cetearyl alcohol in the examples.

[0044] In terms of mass percentage, the skin care composition provided by the present invention comprises 3-4% of an emulsifier. Specifically 4% in the examples. In the present invention, the emulsifier preferably comprises C12-16 alcohol, hydrogenated lecithin, palmitic acid, glyceryl stearate, PEG-100 stearate, polyacrylamide, C13-14 isoparaffin and laureth-7. The emulsifier preferably comprises Biophilic TM H, SIMULSOL 165 and SEPIGEL 305. The Biophilic TM H preferably comprises C12-16 alcohol, hydrogenated lecithin and palmitic acid. In the Biophilic TM H: the mass percentage of C12-16 alcohol is preferably 57%, the mass percentage of hydrogenated lecithin is preferably 18%, and the mass percentage of palmitic acid is preferably 25%. The SIMULSOL 165 preferably comprises glyceryl stearate and PEG-100 stearate. In the SIMULSOL 165: the mass percentage of glyceryl stearate is preferably 50%, and the mass percentage of PEG-100 stearate is preferably 50%. The SEPIGEL 305 preferably comprises polyacrylamide, water, C13-14 isoparaffin and laureth-7. In the SEPIGEL 305: the mass percentage of polyacrylamide is preferably 40%, the mass percentage of water is preferably 30%, the mass percentage of C13-14 isoparaffin is preferably 24%, and the mass percentage of laureth-7 is preferably 6%. In the present invention, the mass percentage of each component of the emulsifier in the skin care composition is preferably: Biophilic TM H 1.4-1.5%, SIMULSOL 165 1.8-2% and SEPIGEL 305 0.4-0.5%; more preferably Biophilic TM H 1.5%, SIMULSOL 165 2% and SEPIGEL 305 0.5%.

[0045] In terms of mass percentage, the skin care composition provided by the present invention comprises 10-16%, preferably 12-15%, more preferably 13-14% of emollients. In the present invention, the emollients include lysophosphatidylcholine, scleroglucan, xanthan gum, pullulan, macadamia nut oil, hydrogenated macadamia nut oil, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter, polydimethylsiloxane and cetearyl dimethicone crosspolymer. The emollients preferably include Ecogel TM , macadamia nut oil, hydrogenated macadamia nut oil, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter, polydimethylsiloxane and cetearyl dimethicone crosspolymer; the mass percentage of each component of the emollients in the skin care composition is preferably: Ecogel TM 0.25-0.3%, macadamia nut oil 0.7-1.4%, hydrogenated macadamia nut oil 0.3-0.6%, ethylhexyl palmitate 2-3%, caprylic / capric triglyceride 2-3%, shea butter 2-3%, polydimethylsiloxane 0.82-1.64%, cetearyl dimethicone crosspolymer 0.18-0.36%. In a specific embodiment of the present invention, the emollients specifically include Ecogel TM , MacadamiaNutButter, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter (BUTYROSPERMUMPARKII) and Velvesil DM LC gel. The mass percentage of each component of the emollients in the skin care composition is specifically: Ecogel TM 0.3%, Macadamia Nut Butter 2%, ethylhexyl palmitate 3%, caprylic / capric triglyceride 3%, shea butter (BUTYROSPERMUM PARKII) 3% and Velvesil DM LC gel 2%. The Ecogel TM preferably includes lysophosphatidylcholine, scleroglucan, xanthan gum, pullulan and silica. The Ecogel TMIn terms of mass percentage content: the mass percentage content of lysophosphatidylcholine is preferably 35%, the mass percentage content of scleroglucan is preferably 34%, the mass percentage content of xanthan gum is preferably 14%, the mass percentage content of pullulan is preferably 14%, and the mass percentage content of silica is preferably 3%. The Macadamia NutButter preferably comprises Macadamia ternifolia seed oil and hydrogenated Macadamia ternifolia seed oil. In the Macadamia NutButter: the mass percentage content of Macadamia ternifolia seed oil is preferably 70%, and the mass percentage content of hydrogenated Macadamia ternifolia seed oil is preferably 30%. The ethylhexyl palmitate is specifically C24 RC. The triglyceride of caprylic acid / capric acid is specifically 318RC. The shea butter (Butyrospermum parkii) is specifically OLVEA Vegetable Oils. The Velvesil DM LC gel preferably comprises polydimethylsiloxane and cetearyl dimethicone crosspolymer. In the Velvesil DM LC gel: the mass percentage content of polydimethylsiloxane is preferably 82%, and the mass percentage content of cetearyl dimethicone crosspolymer is preferably 18%.

[0046] In terms of mass percentage, the skin care composition provided by the present invention comprises 0.5 - 0.6% of antioxidant, specifically 0.6% in the examples. In the present invention, the antioxidant comprises p-hydroxyacetophenone.

[0047] In terms of mass percentage, the skin care composition provided by the present invention comprises 14 - 22% of skin conditioner, preferably 15 - 21%, more preferably 16 - 20%. In the present invention, the skin conditioner comprises triglyceride of caprylic acid / capric acid, Centaurea cyanus extract, rosemary leaf oil, animal thymus extract, ginseng root extract, asiatic pennywort extract and dipotassium glycyrrhizinate. In the present invention, the mass percentage content of each component of the skin conditioner in the skin care composition is preferably: triglyceride of caprylic acid / capric acid 2.5 - 3%, Centaurea cyanus extract 0.06 - 0.1%, rosemary leaf oil 0.01 - 0.03%, animal thymus extract 6 - 10%, ginseng root extract 3 - 5%, asiatic pennywort extract 2.5 - 3.5% and dipotassium glycyrrhizinate 0.1 - 0.2%.

[0048] In a specific embodiment of the present invention, the skin conditioner preferably comprises GATULINE IN-TENSE MB, rosemary (ROSMARINUS OFFICINALIS) leaf oil, EI-500, ginseng root extract, centella asiatica extract, and dipotassium glycyrrhizate. The mass percentage content of each component of the skin conditioner in the skin care composition is specifically 1-3% of GATULINE IN-TENSE MB, 0.01-0.03% of rosemary (ROSMARINUS OFFICINALIS) leaf oil, 5-10% of EI-500, 1-5% of ginseng root extract, 1-3.5% of centella asiatica extract, and 0.1-0.2% of dipotassium glycyrrhizate. The GATULINE IN-TENSE MB preferably comprises triglyceride caprylate / caprate and acmella oleracea extract. In the GATULINE IN-TENSE MB, the mass percentage content of triglyceride caprylate / caprate is preferably 97% and the mass percentage content of acmella oleracea extract is preferably 3%. The rosemary (ROSMARINUS OFFICINALIS) leaf oil is specifically ROSEMARY ESSENTIAL OIL. The EI-500 comprises water and (animal) thymus extract. In the EI-500, the mass percentage content of water is preferably 50% and the mass percentage content of (animal) thymus extract is preferably 50%. The main active ingredients of the (animal) thymus extract are polypeptide active substances, amino acids, and polynucleotide mixtures, etc. The (animal) thymus extract can significantly scavenge free radicals and has excellent antioxidant ability; it can improve skin hydration and reduce the transdermal water loss rate, having a certain degree of moisturizing effect. The ginseng root extract comprises water, ginseng (PANAX GINSENG) root extract, glycerin, 1,2-hexanediol, and p-hydroxyacetophenone. In the ginseng root extract, the mass percentage content of water is preferably 88.8%, the mass percentage content of ginseng (PANAX GINSENG) root extract is preferably 5%, the mass percentage content of glycerin is preferably 5%, the mass percentage content of 1,2-hexanediol is preferably 0.7%, and the mass percentage content of p-hydroxyacetophenone is preferably 0.5%. The centella asiatica extract comprises water, centella asiatica (CENTELLA ASIATICA) extract, glycerin, 1,2-hexanediol, and p-hydroxyacetophenone. In the centella asiatica extract, the mass percentage content of water is preferably 88.8%, the mass percentage content of centella asiatica (CENTELLA ASIATICA) extract is preferably 5%, the mass percentage content of glycerin is preferably 5%, the mass percentage content of 1,2-hexanediol is preferably 0.7%, and the mass percentage content of p-hydroxyacetophenone is preferably 0.5%. The dipotassium glycyrrhizate is specifically Dipotassium Glycyrrhizate.

[0049] In terms of mass percentage, the skin care composition provided by the present invention comprises 0.2 - 0.25% of a pH regulator, specifically 0.25% in the examples. In the present invention, the pH regulator is preferably triethanolamine.

[0050] In terms of mass percentage, the skin care composition provided by the present invention comprises 0.6 - 0.8% of a preservative, specifically 0.8% in the examples. In the present invention, the preservative comprises phenoxyethanol and ethylhexylglycerin. In a specific embodiment of the present invention, the preservative is SY-Exp. In SY-Exp: the mass percentage of phenoxyethanol is preferably 90% and that of ethylhexylglycerin is preferably 10%.

[0051] In terms of mass percentage, the skin care composition provided by the present invention comprises 0.1 - 0.2% of a fragrance, specifically 0.2% in the examples. In the present invention, the fragrance is preferably essence.

[0052] In terms of mass percentage, the skin care composition provided by the present invention comprises the balance of water.

[0053] The present invention provides a preparation method of the skin care composition described in the above technical solution, comprising the following steps:

[0054] Mix the components constituting the skin care composition to obtain the skin care composition.

[0055] In the present invention, the mixing preferably comprises the following steps:

[0056] Perform a first mixing on phase A, phase B and phase C to obtain a first mixture. In the present invention, phase A is the first part of humectants, chelating agent and part of thickeners. The first part of humectants is preferably water and Hispagel 200. The part of thickeners is preferably acrylate / C10-30 alkyl acrylate crosslinked polymer. Phase B is preferably the first part of emulsifiers, part of emollients, the second part of humectants and antioxidants. The first part of emulsifiers is preferably Biophilic TM H. The part of emollients is preferably Ecogel TMThe second part of the humectant is preferably glycerol and propylene glycol. The C phase consists of the remaining thickeners, the second part of the emulsifiers, the remaining emollients, the remaining humectants, and part of the skin conditioners. The remaining thickener is preferably cetearyl alcohol. The second part of the emulsifier is preferably SIMULSOL 165. The remaining emollients are preferably Macadamia Nut Butter, ethylhexyl palmitate, triglyceride of caprylic acid / capric acid, shea (BUTYROSPERMUMPARKII) butter, and Velvesil DM LC gel. The remaining humectant is preferably hydrogenated polyisobutene. The part of the skin conditioner is preferably GATULINE IN-TENSE MB and rosemary (ROSMARINUS OFFICINALIS) leaf oil. The temperature of the first mixing is preferably 80 - 85°C. The first mixing preferably includes: mixing the components in the A phase to obtain an A-phase solution; mixing the components in the B phase to obtain a B-phase solution; mixing the components in the C phase to obtain a C-phase solution. The temperature for mixing the components in the A phase is preferably 80 - 85°C, and the rotation speed is preferably 20 revolutions per minute. The temperature for mixing the components in the B phase is preferably 80 - 85°C, the rotation speed is preferably 20 revolutions per minute, and the time is preferably 30 min. The temperature for mixing the components in the C phase is preferably 80 - 85°C, the rotation speed is preferably 25 - 30 revolutions per minute, and the time is preferably 15 min. Mix the A-phase solution and the B-phase solution, add the C-phase solution after swelling, then carry out heat preservation stirring, and finally carry out homogenization to obtain the first mixture. The temperature of the heat preservation stirring is preferably 80 - 85°C, the rotation speed is preferably 25 - 30 revolutions per minute, and the time is preferably 15 min. The rotation speed of the homogenization is preferably 20 revolutions per minute, and the time is preferably 2 minutes. After homogenization, a first mixture without oil-water separation is obtained.

[0057] After obtaining the first mixing, the present invention mixes the first mixture, the D phase, the E phase, and the F phase to carry out the second mixing to obtain a second mixture. The temperature of the second mixing is 50 - 55°C. The D phase is a pH regulator. The E phase is the remaining emulsifier. The F phase is a preservative. In the present invention, the second mixing is preferably: heating the D phase, the E phase, and the F phase to the first mixture in sequence. The temperature when the D phase is added is 50 - 55°C, the rotation speed is preferably 25 - 30 revolutions per minute, and the time is preferably 15 - 30 min. The temperature when the E phase is added is 50 - 55°C, the rotation speed is preferably 25 - 30 revolutions per minute, and the time is preferably 15 - 30 min. The temperature when the F phase is added is 50 - 55°C, the rotation speed is preferably 25 - 30 revolutions per minute, and the time is preferably 15 - 30 min.

[0058] After obtaining the second mixture, the present invention mixes the second mixture, the G phase and the H phase for a third time to obtain the skin care composition. The temperature of the third mixing is preferably 40-45 °C. The G phase is the remaining skin conditioner, and the H phase is the fragrance. The remaining skin conditioner is preferably EI-500, ginseng root extract, centella asiatica extract and dipotassium glycyrrhizinate. In the present invention, the third mixing is preferably as follows: the G phase and the H phase are sequentially heated into the second mixture. The temperature when the G phase is added is preferably 40-45 °C, the rotation speed is preferably 25-30 revolutions per minute, and the time is preferably 15-20 min. The temperature when the H phase is added is preferably 40-45 °C, the rotation speed is preferably 25-30 revolutions per minute, and the time is preferably 15-20 min.

[0059] The third mixing directly obtains the third mixture. After the stirring of the present invention is stopped, the third mixture is sampled to detect the physical and chemical indexes and microorganisms. After the physical and chemical indexes are qualified, the product is discharged to obtain the skin care composition. Then, after the skin care composition passes the microorganism detection, it is filled; then, after inkjet coding, box packing and sealing, it is stored in the warehouse for inspection; finally, the finished product is sampled, and after passing the inspection, it is released and stored in the qualified area of the warehouse.

[0060] The present invention provides the application of the skin care composition described in the above technical solution or the skin care composition prepared by the preparation method described in the above technical solution in cosmetics. The cosmetics have one or more of the functions of moisturizing, anti-wrinkle, soothing and repairing. The cosmetics preferably have the functions of moisturizing, anti-wrinkle, soothing and repairing.

[0061] In the present invention, the cosmetics include lotion, cream or essence.

[0062] From 11 pm to 5 am is the time when skin cells grow and repair most vigorously. At this time, the speed of cell division is about 8 times faster than usual. Performing beauty care during this period can make skin care products more easily absorbed by the human body, stimulate the vitality of skin cells, improve skin moisture, strengthen the basal barrier, repair fragile skin, activate skin energy, and thus make the skin more delicate. In the present invention, the cosmetics having the functions of moisturizing, anti-wrinkle, soothing and repairing are preferably cream, specifically night cream.

[0063] In order to further illustrate the present invention, the technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they cannot be understood as limiting the protection scope of the present invention.

[0064] The raw materials and reagents used in the following examples and test examples are shown in Table 1.

[0065] The equipment used in the following examples and test examples includes:

[0066] HORUSBASIC dynamic dryness analyzer, manufactured by FORMULACTION, France; Metis skin detector, manufactured by DJM, Germany; Quintix35-1CN digital display electronic balance, manufactured by Sartorius Instrument Systems Co., Ltd., Beijing; HH-8 digital display constant temperature purification water bath, manufactured by Guohua Electric Appliance Co., Ltd., and other instruments.

[0067] Example 1

[0068] The types and dosages of the components in the skin care composition provided by the present invention are shown in Table 1.

[0069] Table 1 Types and dosages of the components in the skin care composition provided by Example 1

[0070]

[0071]

[0072] The preparation method of the skin care composition provided in this example specifically includes:

[0073] (1) Add the water in Phase A to the main tank, then evenly spread U20 on the water surface and soak until complete. Then add EDTA 2 Na, Hispagel 200, and p-hydroxyacetophenone in Phase A to the main tank, heat up and stir (20 revolutions per minute) to 80 - 85 °C until completely dissolved;

[0074] Disperse Biophilic H and Ecogel in Phase B evenly with glycerol and propylene glycol, then add them to the main tank and keep warm and stir (20 revolutions per minute) at 80 - 85 °C for 30 min;

[0075] (2) Add the raw materials in Phase C to the oil tank in sequence, stir (25 - 30 revolutions per minute), heat up to 80 - 85 °C and keep warm for 15 minutes until completely dissolved;

[0076] (3) When Phase A and Phase B are stirred until swollen, pump Phase C into the main tank, keep warm and stir (25 - 30 revolutions per minute) for 15 minutes to make them completely mixed, then homogenize (20 revolutions per minute) for 2 minutes until there is no water-oil separation, and then cool down to 50 - 55 °C;

[0077] (4) Add Phase D to the main tank, stir (25 - 30 revolutions per minute) and keep warm for 15 - 20 minutes until completely uniform;

[0078] (5) Add Phase E to the main tank, stir (25 - 30 revolutions per minute) and keep warm for 15 - 20 minutes until completely uniform;

[0079] (6) Add Phase F to the main tank, stir (25 - 30 revolutions per minute) and keep warm for 15 - 20 minutes until completely uniform, and then cool down to 40 - 45 °C;

[0080] (7) Add phase G to the main tank in sequence, stir (at 25 - 30 revolutions per minute) and keep warm for 15 - 20 minutes until it is completely uniform;

[0081] (8) Add phase H to the main tank, stir (at 25 - 30 revolutions per minute) and keep warm for 15 - 20 minutes until it is completely uniform;

[0082] (9) Stop stirring, take samples to detect physical and chemical indicators and microorganisms, and discharge after the physical and chemical indicators are qualified;

[0083] (10) Carry out filling after the microorganisms are qualified;

[0084] (11) After inkjet coding, box loading, and cigarette sealing, store in the warehouse for inspection;

[0085] (12) Take samples of the finished product, release after passing the inspection, and put them into the qualified area of the warehouse.

[0086] Test Example

[0087] 1 Test Method

[0088] 1.1 Laboratory Test

[0089] 1.1.1 Test Equipment and Principle

[0090] Utilize the diffusive wave spectroscopy technology developed based on the dynamic light scattering theory of the dynamic dryness analyzer to detect the moisturizing performance of the skin care composition provided in Example 1. When light irradiates the sample, photons penetrate into the sample and undergo backscattering with the substances in the sample. The movement of particles causes fluctuations in the light intensity in the speckle and overall deformation of the speckle. When the coating film gradually forms, the movement speed of the scattering particles will decrease due to the reduction of the liquid component in the film, the increase in viscosity, and the cross-linking of the molecular framework in the film structure.

[0091] During the film formation process, the change in the movement of the scattering particles changes with the change in the internal fluidity of the film. The change in the flow factor is related to the deformation of the speckle caused by the movement of the scattering particles in the sample. By quantifying the speed of the speckle deformation, a curve of the change of the flow factor with time is plotted.

[0092] 1.1.2 Test Method

[0093] Set up an experimental group and a blank group. Experimental method for the experimental group: Use a four-sided preparation device to apply the sample on a test-grade stainless steel plate with a coating thickness of 25 mm, place it at a designated location, make the infrared ray irradiate vertically on the center of the stainless steel plate without being blocked, and close the protective cover. Experimental method for the blank group: Place a test-grade stainless steel plate without applying any sample on the fixed floor and irradiate it with a dynamic dryness analyzer. Control the temperature in the test chamber to be (25 ± 1) °C, the humidity to be (10% ± 1%), and the test duration to be 24 h.

[0094] 1.2 Human Efficacy Evaluation Test

[0095] 1.2.1 Test Equipment and Principle

[0096] Use the professional facial image analyzer Metis to conduct skin detection, quantitatively analyze data such as fine lines, pores, spots, and sensitivity of the skin of the subjects, including test data of people with different skin types. The Metis skin detector has five built-in light source modes. For this test, the following are selected: ① Standard light map: Soft standard light, reducing the influence of bright spots and shadows, suitable for quantitative analysis of most surface skin parameters in the present invention. ② Polarized light map: Using polarized light technology, a vertical light source is generated through vertical polarized light to remove plane reflected light, and deeper skin problems such as telangiectasia and skin inflammation can be observed. ③ Skin texture map: Using polarized light technology, a parallel light source is generated through parallel polarizers to filter out deep skin problems and highlight surface skin problems, suitable for quantitative analysis of wrinkle parameters in this test.

[0097] 1.2.2 Test Method

[0098] ① Select 6 healthy female subjects with different skin types, aged 25 to 35 years old, and self-evaluate that the fine lines on the forehead, under the eyes, at the corners of the eyes, and nasolabial folds of the face are obvious and the face is relatively rough. ② On the day of the test, the subjects need to clean their faces with the cleansing products provided by the laboratory, enter a test room with a temperature of (25 ± 2) °C and a relative humidity of (45% ± 5%) and sit quietly for 30 minutes. Then, use the Metis skin detector to collect facial images of the subjects and conduct self-evaluation by the subjects. ③ Distribute the test samples. The subjects need to continuously use the test samples for 28 days according to the instructions, and conduct follow-up visits after 7 days, 14 days, 21 days, and 28 days at the specified time. After sitting quietly for 30 minutes in a test room with a temperature of (22 ± 2) °C and a relative humidity of (45% ± 5%), collect facial images of the subjects and conduct self-evaluation by the subjects at the same time. ④ Through the built-in database of the Metis skin detector, compare with people of the same race, age, and skin type. The results are expressed as percentage scores, and analyze skin problems through changes in the facial images of the subjects, so as to preliminarily evaluate the anti-wrinkle, soothing, repair and other effects of the skin care composition prepared in Example 1.

[0099] 1.3 Safety Evaluation

[0100] The results show that the (animal) thymus extract has no cytotoxicity, and there are no abnormalities in the postauricular tests before the subjects use it; there are no adverse reaction evaluations during the follow-up visits of the subjects, such as symptoms like skin allergy, erythema, papules, purifying edema, purifying blisters, etc. In this test, only 6 subjects are selected due to limited test conditions. Although the test data cannot represent all, human efficacy evaluations will be conducted before the product is launched to ensure the effectiveness and safety of the product.

[0101] 2 Results and Discussion

[0102] 2.1 Evaluation and Analysis of Laboratory Tests

[0103] Figure 1 Dynamic drying result graph of the skin care composition prepared for Example 1. The red line is the experimental group, and the blue basic curve is the blank group. As can be seen from Figure 1 it, within 0 min - 7 min, the flow factor of the experimental group rapidly decreased from 1 Hz to 10 -1 Hz, about 100 times that of the blank group, showing a significant immediate moisturizing effect; within 7 min - 4 h, the coating film of the experimental group gradually formed, and the movement speed of the scattering particles would decrease due to the reduction of liquid components in the film, the increase in viscosity, and the cross-linking of molecular frameworks in the film structure. The flow factor decreased from 10 -1 Hz to 10 -2 Hz, about 100 times that of the blank group, and the product had a significant moisturizing effect; within 4 h - 8 h, part of the bound water of the product disappeared, and the moisturizing effect was still higher than that of the blank group; between 8 h - 24 h, the sample gradually dried, the film was completely cured, the deformation speed of the speckle remained constant, the average slope r 2 = 0.02, and the flow factor was about 10 -3 Hz, 10 times that of the blank control group, and there was still a certain moisturizing effect after film curing. Therefore, compared with the blank group, the sample had significant immediate moisturizing property and the moisturizing property lasted at least 8 h.

[0104] 2.2 Performance Analysis of Human Efficacy Tests

[0105] 2.2.1 Anti-Wrinkle

[0106] Figure 2 It is the wrinkle test result graph of the Metis skin detector, Figure 3 and the facial texture analysis graph. Facial wrinkles reflect static wrinkles such as dry lines and fine lines on the face. Generally, the areas where facial wrinkles are most likely to gather are around the eyes, forehead, nose wings, etc. This skin feature will change greatly in the image, Figure 2 and it is the improvement status of the wrinkles of the subjects in 28 days. As can be seen from Figure 2 it, within 28 days of using the sample by 6 subjects, the skin wrinkle scores in the test area showed an increasing trend. The higher the wrinkle score value, the more the wrinkles were reduced, and on the 7th day, 14th day, and 21st day, the wrinkle score values of the subjects were higher than those of the control group (before using the sample). Figure 3 It is the facial texture analysis graph taken by Metis after the subjects used the sample for 0 d and 28 d. As can be seen from Figure 3It can be observed that when the sample was not used, fine lines were present on the forehead, corners of the eyes, under the eyes, and both sides of the nose wings of the subjects, and the density was relatively high. After using the thymopeptide skin care product for 28 days, the facial fine lines were significantly reduced and the skin became firm. This shows that the skin care composition prepared in Example 1 has the effects of removing fine lines and firming the skin.

[0107] 2.2.2 Soothing

[0108] Figure 4 It is a polarized light image. Figure 4 Polarized light images were taken of 6 subjects at 0d, 14d, and 28d. When the subjects did not use the skin care composition prepared in Example 1, the color of the red areas on the forehead, under the eyes, both cheeks, and nose wings was relatively deep. The red areas can represent some skin conditions such as acne, inflammation, allergy, rosacea, or spider nevi. After using the skin care composition prepared in Example 1 for 14 days, the red areas were significantly improved, and the reddened areas on the forehead, under the eyes, and both cheeks decreased and the color became lighter. After the subjects continuously used the sample for 28 days, the sensitive areas of the face were all smaller than those of the control group (before using the sample), and the facial sensitivity of the subjects showed a downward trend. Therefore, the skin care composition prepared in Example 1 has an obvious effect on maintaining stable skin and has a certain repair effect.

[0109] 3.3 Subjective evaluation of the subjects

[0110] The subjective evaluation content of the subjects includes the evaluation of product satisfaction and the improvement of the subjects' facial fine lines, dry lines, flushing, pores, facial contour, etc.

[0111] After 6 subjects used the sample for 28 days, the overall satisfaction of the tested sample was 94%, the overall skin feel satisfaction was 94%. 100% of the subjects thought that the tested sample had good spreading property, 100% of the subjects thought that the tested sample was mild and non-irritating and easy to absorb when applied, 83% of the subjects thought that the skin texture felt finer, 83% of the subjects thought that the dry lines and fine lines were reduced, 83% of the subjects thought that the skin was firmer, 83% of the subjects thought that the skin was more elastic, 83% of the subjects thought that the skin was more purified, moist, plump, 83% of the subjects thought that the skin was healthier, and 0% of the subjects had intolerance during use.

[0112] As can be seen from the above examples, in the skin care composition containing animal thymus extract provided by the present invention:

[0113] (1) The extract of Centaurea cyanus has anti-inflammatory and antioxidant effects. It is rich in alkylamides, which can inhibit the contraction of muscle cells, relax the facial muscles, and can smooth the skin and reduce wrinkles in a short time.

[0114] (2) Lysophosphatidylcholine can improve cell permeability, accelerate the replacement of damaged epidermal cells, and has the effect of promoting skin rejuvenation and anti-wrinkle; hydrogenated phosphatidylcholine has hydrophilicity and promotes the penetration of other nutrients.

[0115] (3) Ginseng root extract, rich in various ginsenosides, can delay skin aging, make the skin shiny, delicate, reduce skin wrinkles, and inhibit the reduction of melanin, enabling the skin to be fair, white, and smooth.

[0116] (4) Centella asiatica extract: contains various α-amyrin-type triterpenoid components, has antibacterial activity, anti-inflammatory activity, and promotes the synthesis of fibroblasts and collagen;

[0117] (5) Rosemary leaf oil has strong antioxidant activity and inhibits the formation of melanin. It also has strong anti-inflammatory activity, can protect the skin, promote blood circulation, and tighten loose skin;

[0118] (6) Macadamia ternifolia seed oil contains the necessary nutrients for the skin to form an oil protection layer, is mild in oiliness, protects cell membranes, and has good moisturizing, extensibility, and permeability.

[0119] (7) Aureobasidium pullulans polysaccharide is a polysaccharide polymer. When applied to the skin, it will form a thin and elastic moisture-absorbing film, which not only helps with moisturizing but also achieves an immediate tightening effect.

[0120] Thus, the skin care composition containing animal thymus extract provided by the present invention fully exhibits the effects of moisturizing, anti-aging, soothing, and repairing. The skin care composition provided by the present invention can effectively reduce the transdermal water loss rate of the skin, maintain skin moisture, and improve skin elasticity. From the test results of the dynamic dryness analyzer, it can be seen that the skin care composition provided by the present invention has a moisturizing duration of up to 8 hours and still has a certain moisturizing effect after film formation; after 7 days of using the product by the subjects, the wrinkles on the forehead, corners of the eyes, under the eyes, and both sides of the nose wings were improved as measured by Metis; after 28 days of using the product, the wrinkle test score increased significantly; according to the Metis polarized light pictures, over time, the redness areas on the forehead, under the eyes, and both sides of the nose wings of the subjects significantly shrank and the color became lighter. According to the self-evaluation of the subjects, most subjects believed that the product was helpful for maintaining skin moisture, smoothing fine lines, and soothing, and were satisfied with the test results.

[0121] Although the above embodiments have described the present invention in detail, they are only a part of the embodiments of the present invention, not all embodiments. Other embodiments can be obtained based on these embodiments without creative work, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A skin care composition containing an animal thymus extract, characterized in that: Includes the following components in percentage by mass: Moisturizer 8.5-12%, chelating agent 0.01-0.05%, thickener 2-2.3%, emulsifier 3-4%, emollient 10-16%, antioxidant 0.5-0.6%, skin conditioner 14-22%, pH adjuster 0.2-0.25%, preservative 0.6-0.8%, fragrance 0.1-0.2%, balance water; The humectants include glycerin, glyceryl polyacrylate, propylene glycol and hydrogenated polyisobutene; The emollients include lysolecithin, sclerotium gum, xanthan gum, budding pedunculate polysaccharide, macadamia seed oil, hydrogenated macadamia seed oil, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter, dimethicone, and cetearyl dimethicone crosspolymer; The skin conditioning agents include caprylic / capric triglyceride, spilion extract, rosemary leaf oil, animal thymus extract, ginseng root extract, centella asiatica extract, and dipotassium glycyrrhizinate.

2. The skin care composition containing animal thymus extract according to claim 1, characterized in that: The moisturizer comprises Hispagel 200, glycerol, propylene glycol and hydrogenated polyisobutylene; the mass percentage of each component of the moisturizer in the skin care composition is: Hispagel 200 1.5-2%, glycerol 3-4%, propylene glycol 3-4% and hydrogenated polyisobutylene 1-2%.

3. The skin care composition containing animal thymus extract according to claim 1, characterized in that: The emollients include Ecogel TM , macadamia seed oil, hydrogenated macadamia seed oil, ethylhexyl palmitate, caprylic / capric triglyceride, shea butter, dimethicone and cetearyl dimethicone crosspolymer; the mass percentage of each component of the emollient in the skin care composition is: Ecogel TM 0.25-0.3%, macadamia seed oil 0.7-1.4%, hydrogenated macadamia seed oil 0.3-0.6%, ethylhexyl palmitate 2-3%, caprylic / capric triglyceride 2-3%, shea butter 2-3%, polydimethylsiloxane 0.82-1.64%, cetearyl polydimethylsiloxane crosspolymer 0.18-0.36%.

4. The skin care composition containing animal thymus extract according to claim 1, characterized in that: The mass percentages of the skin conditioning agents in the skin care composition are as follows: 2.5-3% of caprylic / capric triglyceride, 0.06-0.1% of schizonepeta extract, 0.01-0.03% of rosemary leaf oil, 6-10% of animal thymus extract, 3-5% of ginseng root extract, 2.5-3.5% of Centella asiatica extract and 0.1-0.2% of dipotassium glycyrrhizinate.

5. The skin care composition containing animal thymus extract according to claim 1, characterized in that: The emulsifiers include C12-16 alcohol, hydrogenated lecithin, palmitic acid, glyceryl stearate, PEG-100 stearate, polyacrylamide, water, C13-14 isoparaffin and laureth-7.

6. The skin care composition containing animal thymus extract according to claim 5, characterized in that: The emulsifier includes Biophilic TM H, SIMULSOL 165 and SEPIGEL 305; the mass percentage of each component of the emulsifier in the skin care composition is: Biophilic TM H 1.4~1.5%, SIMULSOL 165 1.8~2% and SEPIGEL 305 0.4~0.5%.

7. The skin care composition containing animal thymus extract according to claim 1, characterized in that: The chelating agent is disodium EDTA; The thickener includes acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer and / or cetearyl alcohol; The antioxidant includes p-hydroxyacetophenone; The pH regulator is triethanolamine; The preservatives include phenoxyethanol and ethylhexylglycerin; The aromatic agent is essence.

8. The method for preparing the skin care composition containing animal thymus extract according to any one of claims 1 to 7, characterized in that: The following steps are involved: The various components constituting the skin care composition containing the animal thymus extract are mixed to obtain the skin care composition containing the animal thymus extract.

9. The preparation method according to claim 8, characterized in that: The mixing comprises the following steps: Phase A, phase B and phase C are first mixed to obtain a first mixture, wherein the temperature of the first mixing is 80-85° C., the phase A is water, a first part of a moisturizer, a chelating agent and a part of a thickener, the phase B is a first part of an emulsifier, a part of an emollient, a second part of a moisturizer and an antioxidant, and the phase C is the remaining thickener, the second part of an emulsifier, the remaining emollient, the remaining moisturizer and a part of a skin conditioner; The first mixture, phase D, phase E and phase F are mixed for the second time to obtain a second mixture, wherein the temperature of the second mixing is 50-55° C., the phase D is a pH regulator, the phase E is a residual emulsifier, and the phase F is a preservative; The second mixture, phase G and phase H are mixed for the third time to obtain the skin care composition. The temperature of the third mixing is 40-45° C., the phase G is the remaining skin conditioner, and the phase H is the fragrance.

10. Use of the skin care composition containing animal thymus extract according to any one of claims 1 to 7 or the skin care composition containing animal thymus extract prepared by the preparation method according to claim 8 or 9 in cosmetics, characterized in that: The cosmetic has one or more of moisturizing, anti-wrinkle, soothing and repairing effects.

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