Anti-fatigue medicated diet and preparation method thereof
By combining Chonglou with animal meat to make an anti-fatigue medicinal diet, the problem of lack of effective anti-fatigue medicinal diet in the prior art is solved, and the effect of reducing lactic acid accumulation, promoting energy metabolism and improving antioxidant capacity is achieved, which significantly relieves muscle fatigue.
Patent Information
- Application Number
- CN202510453739.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-11
- Publication Date
- 2025-06-06
AI Technical Summary
The prior art lacks a medicinal diet that is widely applicable, can prevent or delay the generation of fatigue, promote fatigue elimination, is healthy, non-toxic and has antioxidant activity.
It provides an anti-fatigue medicinal meal, including glutinous rice and animal meat (poultry meat and animal meat), which is made by washing, cutting, adding ginger, cooking wine, oil, salt and other seasonings, boiling and slowly simmering.
This medicinal diet can reduce the accumulation of lactic acid during exercise, promote energy metabolism, improve antioxidant ability, relieve muscle fatigue, significantly prolong the swimming time of exhaustion in mice, increase the SOD level in the serum, and reduce LD and MDA levels.
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Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to an anti-fatigue medicinal diet and a preparation method thereof. Background Art
[0002] Fatigue is the result of complex physiological and biochemical changes in the body. From the central nervous system to skeletal muscle cells and then to the material metabolism process in the cell, any comprehensive change in any link or process in the middle can cause fatigue. Fatigue not only reduces the body's original working ability, but also indicates that the body has developed to a certain degree of injury and disease. After the human body is in a state of fatigue, if it is not treated and eliminated in time, it will gradually accumulate, eventually leading to overwork and chronic fatigue syndrome. Chinese medicine has a very good effect on conditioning the body. Compared with Western medicine, Chinese medicine has less toxic and side effects and is suitable for long-term use. For diseases that require long-term treatment, Chinese medicine has incomparable advantages over Western medicine. Under the guidance of traditional Chinese medicine, culinary and nutritional theories, Chinese medicine is strictly combined with certain foods with medicinal value in accordance with the formula of medicinal diet, and delicious food is made using my country's unique dietary cooking technology and modern scientific methods. It "combines medicine with food", not only uses medicine as food, but also gives food medicinal properties. Medicine borrows the power of food, and food helps the power of medicine. The two complement each other and bring out the best in each other.
[0003] Since the use of medicinal diets needs to be based on symptoms, time, people and places, there is currently no widely applicable, healthy and non-toxic medicinal diet with antioxidant activity that can prevent or delay the occurrence of fatigue, promote fatigue elimination, and is safe and non-toxic. Summary of the invention
[0004] In order to overcome the above technical defects, the present invention provides an anti-fatigue medicinal diet which is easy to prepare, conforms to people's eating habits, has low cost, has no side effects, can reduce the accumulation of lactic acid during exercise, promote energy metabolism, improve antioxidant capacity, and relieve muscle fatigue.
[0005] One of the purposes of the present invention is to provide an anti-fatigue medicinal diet, comprising the following raw materials in parts by weight: 200-500 parts of Paris polyphylla and 100-1000 parts of animal meat.
[0006] Paris polyphylla, bitter in taste, slightly cold in nature; it enters the liver meridian, has the effects of clearing away heat and detoxifying, reducing swelling and relieving pain, cooling the liver and calming the nerves. It is mainly used to treat carbuncle, sore throat, snake bites, convulsions, and injuries from falls.
[0007] Furthermore, the animal meat includes poultry meat and / or livestock meat.
[0008] Further, the anti-fatigue medicinal diet comprises 250-400 portions, or 300-500 portions, or 350-500 portions, or 400-500 portions, or 400-450 portions of Paris polyphylla; and
[0009] 300-1800 portions, or 400-1500 portions, or 500-1200 portions, or 600-1000 portions of poultry; and
[0010] 100-800 portions, or 200-600 portions, or 300-500 portions of livestock meat.
[0011] Furthermore, the poultry meat is selected from one or more of chicken, duck, goose, quail and pigeon.
[0012] In some specific embodiments, the poultry meat is selected from chicken, which is warm in nature and can "warm the middle and replenish qi, replenish essence and fill marrow", and is suitable for symptoms such as dizziness and fatigue caused by insufficient qi and blood, and weak spleen and stomach.
[0013] Furthermore, the livestock meat is selected from one or more of pigs, cattle, sheep, rabbits, dogs and horses.
[0014] In some specific embodiments, the livestock meat is selected from pig tripe, which is warm in nature, enters the spleen and stomach meridians, can replenish qi, improve spleen and stomach weakness, and alleviate insufficient nutrient absorption and fatigue caused by indigestion.
[0015] Furthermore, the anti-fatigue medicinal diet also includes seasonings, and the seasonings include one or more of natural spices, edible salt, white sugar, vegetable oil, and cooking wine.
[0016] The second purpose of the present invention is to provide a method for preparing an anti-fatigue medicinal diet. The Paris polyphylla and animal meat are washed, cut into pieces, placed in a container, and a small amount of ginger, cooking wine, oil, and salt are added. After boiling over high heat, the mixture is simmered over low heat for 1-3 hours before consumption.
[0017] In some specific embodiments, Paris polyphylla and animal meat are placed in a casserole, water is added and boiled, then the boiled water is poured out, and then water is added, and a small amount of ginger, cooking wine, oil, and salt are added. After boiling over high heat, simmer over low heat for 3 hours before serving.
[0018] In some specific embodiments, Paris polyphylla is put into a casserole, and an appropriate amount of water is added and stewed for 4 hours; animal meat is added into water and boiled, and then the boiled water is poured out, and then water is added, and a small amount of ginger, cooking wine, oil, and salt are added. After boiling over high heat, simmer over low heat for 3 hours, the mixture is removed and mixed with Paris polyphylla in a casserole, and stewed for another 0.5 hours before being eaten.
[0019] The third purpose of the present invention is that the anti-fatigue effect of the above-mentioned medicinal diet and the medicinal diet prepared by the above-mentioned method is also within the scope of protection required by the present invention.
[0020] Furthermore, the mechanism of action is manifested as increasing the SOD level in serum and decreasing the LD level; decreasing the MDA level in the liver and increasing the GSH level.
[0021] The present invention is the first to combine the Chinese medicinal material Paris polyphylla with chicken and pork tripe to make a medicinal diet that is both preventive and therapeutic, and the effect is remarkable. Paris polyphylla's heat-clearing and detoxifying and immune-regulating functions help to remove "heat-toxic" factors in the body that may affect the normal functions of the body, stabilize the body's internal environment, and reduce fatigue caused by factors such as inflammation or infection; chicken is rich in high-quality protein, multiple vitamins (such as B vitamins), minerals (such as iron, zinc, etc.) and taurine and other nutrients; pork tripe mainly plays a role in strengthening the spleen and stomach. The three work synergistically to make the body's metabolism smoother, improve the efficiency of energy generation and utilization, and reduce the accumulation of fatigue substances (such as lactic acid, etc.) in the body, thereby relieving fatigue.
[0022] The medicinal diet of the present invention has the characteristics of food such as color, fragrance and taste; even if some medicinal materials are added, it can still be made into delicious medicinal diet by paying attention to the selection of medicinal properties and flavors, and through the blending with food and fine cooking, so it is called "good medicine is delicious and easy to take", which can not only cure diseases, but also strengthen the body and prevent diseases. The preparation method of the present invention uses various ingredients to directly enter the formula, maintains the original flavor and original medicinal properties, can maximize the effective role of each ingredient, has a simple preparation process, is suitable for home use, and is also suitable for factory-scale production. DETAILED DESCRIPTION
[0023] In order to make those skilled in the art better understand the technical solution of the present invention, the present invention is described in detail below in conjunction with specific embodiments. The experimental methods in the following examples that do not specify specific conditions are usually based on conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, percentages and parts are calculated by weight. Unless otherwise defined, all professional and scientific terms used in the text have the same meanings as those familiar to those skilled in the art. In addition, any method and material similar or equivalent to the recorded content can be applied to the present invention. The preferred implementation methods and materials described in the text are for demonstration purposes only.
[0024] The endpoints and any values of the ranges disclosed in this article are not limited to the precise ranges or values, and these ranges or values should be understood to include values close to these ranges or values. For numerical ranges, the endpoint values of each range, the endpoint values of each range and the individual point values, and the individual point values can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed in this article.
[0025] The present invention selects Paris polyphylla, chicken and pig's stomach to form a medicinal diet composition. In the anti-fatigue medicinal diet, Paris polyphylla's heat-clearing and detoxifying and immune-regulating functions help to remove the "heat-toxic" factors that may affect the normal functions of the body, stabilize the body's internal environment, and reduce the fatigue caused by factors such as inflammation or infection. Its immune-regulating function can enhance the body's resistance and improve the body's ability to cope with fatigue-producing factors. Chicken provides a rich nutrient basis for medicinal diet. High-quality protein is an important raw material for body repair and maintenance of normal physiological functions, and is essential for relieving fatigue and restoring physical strength; B vitamins participate in the energy metabolism process in the body, can promote the metabolism of carbohydrates, fats and proteins, and help convert food into energy, thereby reducing fatigue; taurine has multiple functions such as regulating osmotic pressure, anti-oxidation, and enhancing myocardial contractility, and has a positive effect on improving fatigue. Pig's stomach improves the digestion and absorption function of the spleen and stomach by strengthening the spleen and stomach, so that the nutrients in chicken and Paris polyphylla can be better absorbed and utilized by the human body. At the same time, nutrients in pig stomach such as protein, vitamins and minerals also provide material support for anti-fatigue. Collagen helps maintain the normal structure and function of body tissues. Vitamins A and E have antioxidant effects, which can reduce the damage of free radicals to the body and thus relieve fatigue.
[0026] Based on the present invention, the anti-fatigue medicinal diet includes 250-400 portions, or 300-500 portions, or 350-500 portions, or 400-500 portions, or 400-450 portions of Paris polyphylla; and
[0027] 300-1800 portions, or 400-1500 portions, or 500-1200 portions, or 600-1000 portions of chicken; and
[0028] 100-800 portions, or 200-600 portions, or 300-500 portions of pork belly.
[0029] It is understood by those skilled in the art that the "parts by weight" of each component represents the dosage ratio of each component, rather than the actual mass unit. According to actual conditions, the unit weight part can be any mass, such as 1 part by weight can be 1g, 500g or 1kg, or even 15g, 30g, etc.
[0030] Based on the present invention, the anti-fatigue medicinal diet is prepared by the following method: wash and cut Paris polyphylla and animal meat into pieces, put them in a container, add a small amount of ginger, cooking wine, oil and salt, boil over high heat, simmer over low heat for 1-3 hours, and then the food can be eaten.
[0031] In some specific embodiments, the Paris polyphylla is washed, cut into 3-5 mm thick slices, and put into a casserole; the native chicken and pork tripe are washed, the chicken is chopped into small pieces, the pork tripe is cut into strips, and put into the casserole containing the Paris polyphylla, and water is added to boil, and then the boiled water is poured out, and then water is added, and a small amount of ginger, cooking wine, oil, and salt are added. After boiling over high heat, it is simmered over low heat for 3 hours; the cooking method of stewing Paris polyphylla, chicken, and pork tripe at the same time has a distinct aroma, a turbid soup color, and a slightly strong bitter taste.
[0032] In other specific embodiments, the Paris polyphylla is cleaned, cut into 3-5 mm thick slices, put into a casserole, and an appropriate amount of water is added and stewed for 4 hours; animal meat is added into water and boiled, and then the boiled water is poured out, and then water is added, and a small amount of ginger, cooking wine, oil, and salt are added. After boiling over high heat, the mixture is simmered over low heat for 3 hours, taken out, mixed with the Paris polyphylla in a casserole, and stewed for 0.5 hours; the cooking method of stewing Paris polyphylla, chicken, and pork tripe separately first has a beneficial aroma, a clear soup color, a slightly bitter taste when taken, and a sweet after swallowing.
[0033] The embodiments of the present invention will be described in detail below with reference to the examples, but those skilled in the art will appreciate that the following examples are only used to illustrate the present invention and should not be considered to limit the scope of the present invention. If no specific conditions are specified in the examples, the conditions are carried out according to conventional conditions or conditions recommended by the manufacturer.
[0034] Reagents or instruments without indicating the manufacturer are all conventional products that can be obtained through commercial purchase.
[0035] Embodiment 1 Anti-fatigue medicinal diet
[0036] 250 parts by weight of Paris polyphylla, 2000 parts by weight of chicken, and 100 parts by weight of pork tripe.
[0037] Embodiment 2 Anti-fatigue medicinal diet
[0038] 350 parts by weight of Paris polyphylla, 1000 parts by weight of chicken, and 200 parts by weight of pork tripe.
[0039] Embodiment 3 Anti-fatigue medicinal diet
[0040] 400 parts by weight of Paris polyphylla, 1800 parts by weight of chicken, and 600 parts by weight of pork tripe.
[0041] Embodiment 4 Anti-fatigue medicinal diet
[0042] 500 parts by weight of Paris polyphylla, 1500 parts by weight of chicken, and 300 parts by weight of pork tripe.
[0043] Embodiment 5 Anti-fatigue medicinal diet
[0044] 450 parts by weight of Paris polyphylla, 1200 parts by weight of chicken, and 800 parts by weight of pork tripe.
[0045] Investigating the anti-fatigue effect of the medicinal diet of the present invention
[0046] The experimental data were statistically analyzed using SPSS 20.0 statistical software. Measurement data were expressed as . The pairwise comparison between groups was performed using the t-test, and P < 0.05 was considered statistically significant. GraphPad Prism 9.0 was used for chart plotting. P < 0.05 indicates significant differences, and P < 0.01 indicates extremely significant differences.
[0047] Experimental animals: 40 KM mice, half male and half female, 5 - 6 weeks old, with a body weight of (20 ± 2) g, provided by Kunming Medical University [Experimental Animal Production License Number: SCXK(Dian) K2020 - 004]; all mice were housed in the Animal Experiment Center of Yunnan University of Traditional Chinese Medicine, with a relative humidity of 40% - 50% and a room temperature of 20 - 25 °C. They were fed with ordinary feed, allowed to eat freely, and given sufficient water.
[0048] Drug sources: American ginseng powder (Hongxiang Biotechnology Co., Ltd.), batch number: 20230301; normal saline.
[0049] Experimental grouping: 40 KM mice were selected, half male and half female. After the adaptive feeding period, they were randomly divided into a blank group, a control group, a model group, a positive group, and a medicated diet group, with 10 mice in each group. After preliminary experiments, the appropriate drug administration concentration and volume were determined. After fasting for 12 h without water deprivation, the drugs were administered according to Table 1, 2 times a day, and intragastric administration was continued for 7 consecutive days. After that, the experiment was carried out;
[0050] Blank group: 0.6 mL of normal saline was administered daily;
[0051] Model group: 0.6 mL of normal saline was administered daily;
[0052] Positive group: 10 g / kg of American ginseng powder was administered daily;
[0053] Medicated diet group: 0.6 mL of medicated diet extract was administered daily.
[0054] The medicated diet extract was prepared by the following method: Take the Paris vietnamensis medicated diet in Example 3, thaw it in advance. When it becomes a thin slush, put it into a blender and run at the maximum speed for 10 min. Filter it using a non-woven filter cloth. Mix the Paris vietnamensis medicated diet filtered out multiple times and put it into a centrifuge tube and freeze it in an environment of -20 °C for standby.
[0055] Experimental method: Each group of mice was given the drug for 7 consecutive days. 30 minutes after the last drug administration, a lead sheet (lead sheet mass = body mass × 8%) was tied at 1 cm from the base of the mouse's tail and placed in a water tank with a water temperature of 26±2°C for weighted swimming. The timer was started at the same time, and the swimming time was recorded as the time when the mouse sank to the bottom of the water for 5 seconds and no longer floated. After the mouse was anesthetized, the eyeball was removed to collect blood, and the blood was centrifuged at 4°C and 3500rpm for 15 minutes to separate the serum for use; the liver, brain and hind limb muscle of the calf were also collected and placed in a -80°C refrigerator for use.
[0056] (1) Investigating the anti-fatigue effect of medicated diet on mice
[0057] Exhaustion time assessment criteria: mice in each group were judged as exhausted swimming when they sank into the middle of the water for 3 seconds or could not surface for 7 seconds. They were fished out and the time was recorded as the exhaustion swimming time (min). The average value was taken and recorded. The results are shown in Table 1 below:
[0058] Table 1
[0059]
[0060] Note: Compared with the model group, ** P<0.01; compared with the positive drug group, ▲▲ P<0.01
[0061] As can be seen in the table above, compared with the model group, the swimming time of the positive control group was significantly prolonged, and the medicinal diet group was also able to prolong the swimming time of mice, indicating that the medicinal diet can play an anti-fatigue role and thus prolong the exhaustive swimming time of mice. (2) Investigating the effect of the medicinal diet on serum LD and SOD in mice
[0062] When mice are in a state of high-intensity exercise, the decomposition of glycogen in the muscles will produce a large amount of lactic acid. The increase in lactic acid content will lead to a weakening of the body's exercise capacity, so the lactic acid content can indicate the degree of fatigue. Superoxide dismutase (SOD) has antioxidant and anti-aging effects, and its mechanism of action is mainly to remove superoxide anion free radicals that are harmful to the body. The results of LD and SOD determination of each group of mice are shown in Table 2:
[0063] Table 2 Serum LD and SOD levels n=8
[0064]
[0065]
[0066] Note: Compared with the blank group, #### P<0.0001; compared with the model group, ** P<0.01, * P<0.05
[0067] As can be seen from the table above, compared with the blank group, the SOD content of the model group decreased (P<0.0001), and compared with the model group, the SOD levels of the medicated diet group and the positive control group showed an upward trend (P<0.05, P<0.01); compared with the blank group, the LD content of the model group increased significantly (P<0.0001), and compared with the model group, the LD levels of the medicated diet group and the positive control group decreased (P<0.05). This shows that this medicated diet can increase the SOD level, reduce the LD level, and effectively reduce the accumulation of lactic acid in exercise mice.
[0068] (3) Investigate the effect of medicated diet on GSH and MDA levels in mouse liver
[0069] Fatigue caused by exercise can damage the body's antioxidant system. Malondialdehyde (MDA) can reflect the body's potential antioxidant capacity and is an important product of lipid peroxidation in the body. It can reflect the rate and intensity of lipid peroxidation in the body and can also indirectly reflect the degree of tissue peroxidation damage. Glutathione (GSH) can help maintain normal immune system function and has antioxidant and integrated detoxification effects. The results of GSH and MDA determination of each group of mice are shown in Table 3:
[0070] Table 3 GSH and MDA levels in liver n=8
[0071]
[0072] Note: Compared with the blank group, ### P < 0.001, #### P<0.0001; compared with the model group, ** P<0.01, * P<0.05; compared with the positive drug group, ▲ P<0.05
[0073] As can be seen in the table above, compared with the blank group, the GSH content in the model group decreased significantly (P<0.001), and compared with the model group, the GSH content in the medicated diet group and the positive control group increased significantly (P<0.01). Compared with the blank group, the MDA level in the model group increased significantly (P<0.001), and compared with the model group, the MDA levels in the medicated diet group and the positive control group decreased significantly (P<0.05, P<0.01). This shows that medicated diet can reduce MDA in the liver and increase GSH levels.
[0074] Paris polyphylla diet can reduce the content of MDA in the liver and increase the level of SOD in the serum. The increase in GSH content indicates that Paris polyphylla diet can effectively eliminate oxygen free radicals after fatigue, thereby reducing and protecting the body from further damage caused by fatigue. Paris polyphylla diet can reduce MDA in the liver and increase GSH levels. Overall, Paris polyphylla diet has an anti-fatigue effect, and its mechanism may be to reduce the accumulation of lactic acid during exercise, promote energy metabolism, improve antioxidant capacity, and relieve muscle fatigue.
[0075] Finally, it should be noted that the above description is only a preferred embodiment of the present invention. Under the guidance of the present invention, those skilled in the art can make a variety of similar expressions without violating the purpose and claims of the present invention, and such changes all fall within the protection scope of the present invention.
Claims
1. An anti-fatigue medicinal diet, characterized in that: The invention comprises the following raw materials in parts by weight: 200-500 parts of Paris polyphylla and 100-1000 parts of animal meat.
2. The anti-fatigue medicinal diet according to claim 1, characterized in that: The animal meat includes poultry meat and / or livestock meat.
3. The anti-fatigue medicinal diet according to claim 2, characterized in that: Including 250-400 parts, or 300-500 parts, or 350-500 parts, or 400-500 parts, or 400-450 parts of Paris polyphylla; as well as 300-1800 portions, or 400-1500 portions, or 500-1200 portions, or 600-1000 portions of poultry; as well as 100-800 portions, or 200-600 portions, or 300-500 portions of livestock meat.
4. The anti-fatigue medicinal diet according to claim 2, characterized in that: The poultry meat is selected from one or more of chicken, duck, goose, quail and pigeon.
5. The anti-fatigue medicinal diet according to claim 2, characterized in that: The livestock meat is selected from one or more of pigs, cattle, sheep, rabbits, dogs and horses.
6. The anti-fatigue medicinal diet according to claim 1, characterized in that: The invention also comprises seasonings, which include one or more of natural spices, edible salt, white sugar, vegetable oil and cooking wine.
7. A method for preparing the anti-fatigue medicinal diet as claimed in claim 1, characterized in that: Wash and cut the Paris polyphylla and animal meat into pieces, place in a container, add a small amount of ginger, cooking wine, oil, and salt, boil over high heat, then simmer over low heat for 1-3 hours before serving.
8. The method according to claim 7, characterized in that Put Paris polyphylla and animal meat in a casserole, add water and boil, then pour out the boiled water, add water again, a small amount of ginger, cooking wine, oil and salt, boil over high heat, then simmer over low heat for 3 hours before serving.
9. The method according to claim 7, characterized in that: Put Paris polyphylla into a casserole, add appropriate amount of water and simmer for 4 hours; add water to boil the animal meat, then pour out the boiled water, add water again, add a small amount of ginger, cooking wine, oil and salt, boil over high heat, simmer over low heat for 3 hours, remove from the casserole, mix with Paris polyphylla, continue to simmer for 0.5 hours, then it is ready to eat.
10. The anti-fatigue medicinal diet according to any one of claims 1 to 6 and the medicinal diet prepared by the method according to any one of claims 7 to 9 are used to increase the SOD level in serum and reduce the LD level; reduce the MDA level in the liver and increase the GSH level.