Ganoderma lucidum oral liquid containing bamboo leaf flavone and red yeast rice

Abstract

The invention discloses ganoderma lucidum oral liquid containing bamboo leaf flavone and red yeast rice, and relates to the technical field of oral liquid preparation. The health-care food is prepared from the following raw materials in parts by mass: 850-950 parts of ganoderma lucidum, 95-105 parts of red yeast rice, 350-450 parts of bamboo leaf flavone and a proper amount of traditional Chinese medicine auxiliary material powder, the preparation process comprises the following steps: S1, a cleaning procedure: cleaning the ganoderma lucidum for 20 minutes to remove impurities, microorganisms and the like attached to the surface of the ganoderma lucidum so as to create a clean environment for subsequent fermentation; and S2, a ganoderma lucidum fermentation process: under the proper conditions that the temperature is 27-32 DEG C, the relative humidity is 60% and the pH value is 7.2. The ganoderma lucidum is used as a main raw material and matched with the bamboo leaf flavone, the red yeast rice and various traditional Chinese medicine auxiliary materials, so that the nutritional value of the product is greatly improved, and the product has various functions of reducing blood sugar, invigorating the kidney and strengthening Yang, reducing blood pressure, reducing blood fat, resisting aging, calming the heart and tranquilizing the mind, reducing side effects after tumor chemotherapy, promoting blood circulation to remove blood stasis, preventing cerebral thrombosis, invigorating spleen to promote digestion and the like.

Description

Technical Field

[0001] The invention relates to the technical field of oral liquid preparation, in particular to a ganoderma lucidum oral liquid containing bamboo leaf flavonoids and red yeast rice. Background Art

[0002] In today's society, with the continuous development of the economy and the significant improvement of people's living standards, the concept of health and wellness has become more and more popular. The public's demand for health and wellness products is showing a rapid growth and increasingly diversified trend. Ganoderma lucidum, as an extremely rare biological resource, has long been endowed with many magical health benefits in folk legends, such as regulating body functions and delaying aging.

[0003] Ganoderma lucidum, also known as Tai Sui, mainly lives underground or in water. The surface of Ganoderma lucidum is uneven and light yellow, while the inside is white and fibrous. It is very soft and has excellent toughness. In the Compendium of Materia Medica, it is recorded that "Ganoderma lucidum is shaped like meat and is a living thing. The red ones are like coral, the white ones are like fat, the yellow ones are like purple gold, and the black ones are like lacquer. They are all bright and clear like ice." The Shennong's Herbal Classic also records that "Ganoderma lucidum is non-toxic, nourishes the middle, improves the essence and qi, and long-term use will make the body light and not old."

[0004] At the same time, bamboo leaf flavonoids, red yeast rice and a variety of Chinese medicinal materials have shown unique health care potential in their respective research fields. Bamboo leaf flavonoids have excellent antioxidant properties, can effectively remove free radicals in the body, and have a positive effect on preventing cardiovascular diseases; red yeast rice has certain effects in regulating blood lipids, and the ingredients it contains, such as lovastatin, can inhibit cholesterol synthesis; and Chinese medicinal materials such as ginseng, cordyceps militaris, and codonopsis pilosula have their own advantages in improving immunity, nourishing the kidneys and strengthening yang, and calming the mind.

[0005] At present, the research work of organically integrating these ingredients with Ganoderma lucidum to develop comprehensive and synergistic health care functional products is still in its infancy. There is a broad space for exploration and great demand for innovation. To this end, we provide a Ganoderma lucidum oral liquid with bamboo leaf flavonoids and red yeast rice to solve the above-mentioned problems. Summary of the invention

[0006] The purpose of the present invention is to provide a meat ganoderma oral liquid with bamboo leaf flavonoids and red yeast rice, which solves the problem that the oral liquid in the prior art is difficult to meet people's pursuit of comprehensive health care functions through the combination of meat ganoderma, red yeast rice, bamboo leaves and Chinese medicine auxiliary material powder.

[0007] In order to solve the above technical problems, the present invention is achieved through the following technical solutions:

[0008] The invention discloses a meat ganoderma oral liquid containing bamboo leaf flavonoids and red yeast rice, which is composed of the following raw materials in parts by weight: 850-950 parts of meat ganoderma, 95-105 parts of red yeast rice, 350-450 parts of bamboo leaf flavonoids and an appropriate amount of Chinese medicine auxiliary material powder;

[0009] The preparation process includes the following steps:

[0010] S1: Cleaning process: Clean the Ganoderma lucidum for 20 minutes to remove impurities, microorganisms, etc. attached to its surface and create a clean environment for subsequent fermentation;

[0011] S2: Ganoderma lucidum fermentation process: under suitable conditions of temperature at 27-32°C, relative humidity at 60%, and pH at 7.2, the cleaned Ganoderma lucidum is added to a specific culture solution and the "AHCC" spore complex is added for 20 days of fermentation. During this process, Ganoderma lucidum releases its own active ingredients under the action of the specific environment and the "AHCC" spore complex, and at the same time cooperates with the "AHCC" spore complex to improve the quality and efficacy of the fermentation product;

[0012] S3: Red yeast rice pretreatment process: first soak the red yeast rice in cold boiled water for 3-5 hours to allow it to fully absorb water and swell, then place the soaked red yeast rice in an environment of 30-40°C for 2-3 days for fermentation, and after the fermentation is completed, seal the jar and set aside. This step allows the microorganisms in the red yeast rice to fully reproduce and metabolize, producing beneficial components of red yeast pigment;

[0013] S4: Bamboo leaf flavonoid extraction process: the bamboo leaves are crushed, and then an appropriate amount of organic solvent is added and soaked for 1 day to fully dissolve the flavonoids in the bamboo leaves in the organic solvent. After the soaking, a filtrate is obtained by filtering, and the filtrate is concentrated and dried to finally obtain a bamboo leaf flavonoid extract;

[0014] S5: Mixed fermentation and filling process: Add the prepared bamboo leaf flavonoids extract, fermented Monascus and specially formulated Chinese medicine auxiliary powder into a culture tank and ferment them under suitable environmental conditions for 10 days. After the fermentation is completed, the finished product is aseptically filled into pre-sterilized bottles.

[0015] The present invention is further configured that the Chinese medicine auxiliary material powder is made of the following raw materials in parts by weight: 150-250 parts of ginseng, 90-100 parts of cordyceps militaris, 28-32 parts of codonopsis, 25-35 parts of dendrobium officinale, 25-35 parts of tremella, 75-85 parts of yam, 25-35 parts of mulberry, 95-105 parts of angelica, 190-210 parts of spiny jujube seeds, 28-32 parts of honey, 290-310 parts of astragalus, and 25-35 parts of tuckahoe. These Chinese medicine raw materials are compatible according to a specific ratio, and cooperate with ganoderma lucidum, red yeast rice and bamboo leaf flavonoids to jointly enhance the health care effect of the product.

[0016] The present invention is further configured as follows: the specific weight portions of the Chinese medicine auxiliary material powder are: 200 parts of ginseng, 95 parts of cordyceps militaris, 30 parts of codonopsis pilosula, 28 parts of dendrobium officinale, 30 parts of tremella, 80 parts of yam, 30 parts of mulberry, 100 parts of angelica, 200 parts of spiny jujube seeds, 30 parts of honey, 300 parts of astragalus, and 30 parts of poria. The Chinese medicine auxiliary material powder with this specific ratio can accurately exert its efficacy in the product and achieve the best health care effect balance with other ingredients.

[0017] The present invention is further configured that the method for preparing the Chinese medicine auxiliary material powder comprises the following steps:

[0018] Step 1: Raw material pretreatment: Screen and classify the Chinese medicines. Except for honey, wash each Chinese medicine separately to remove surface impurities. After washing, cut the Chinese medicine into sections or pieces, and then reduce its water content by sun drying or drying to facilitate subsequent processing.

[0019] Step 2: Grinding and sieving: Weigh the Chinese medicine excipients according to specific weight portions, directly add honey without adding additional water in an environment with a temperature of 22-25 degrees Celsius and a relative humidity of 65%, and grind them so that the mesh size after grinding reaches 80-100 mesh. After the grinding is completed, remove the particles that do not meet the standards through a sieving operation to obtain a uniform and fine Chinese medicine excipient powder. This preparation method can retain the active ingredients of Chinese medicine to the greatest extent, and at the same time fully integrate honey and Chinese medicine.

[0020] The present invention is further configured that the preparation method of the AHCC spore complex is as follows: the shiitake mushroom strain is cultured at 24-28°C and pH 5.5-6.5. After the strain grows to a specific stage, cellulase and protease are added to decompose the mycelial cell wall and release the intracellular active ingredients, such as α-glucan and low molecular weight polysaccharides, and then vacuum low-temperature concentration technology is used to retain the thermosensitive active substances, and finally ultrafiltration technology is used to intercept the low molecular weight polysaccharide complex with a molecular weight of less than 5000Da to obtain the "AHCC" spore complex, which is added to the fermentation process of Ganoderma lucidum to significantly improve the fermentation effect and product efficacy.

[0021] The present invention is further configured that the strain selected for the AHCC spore complex is Lentinus edodes, which, under specific culture conditions, can efficiently produce bioactive substances with unique advantages compared to other strains, thereby improving the quality and efficacy of the Ganoderma lucidum oral liquid.

[0022] The present invention is further configured such that the solvent is ethanol or methanol. Ethanol and methanol have good solubility, can effectively extract flavonoids from bamboo leaves, and are easy to remove in the subsequent concentration and drying process without adversely affecting product quality and safety. At the same time, they have a wide source and low cost, and are suitable for large-scale production applications.

[0023] The present invention has the following beneficial effects:

[0024] 1. The present invention uses Ganoderma lucidum as the main raw material, and is matched with bamboo leaf flavonoids, red yeast rice and a variety of traditional Chinese medicine excipients, which greatly improves the nutritional value of the product. The product has the functions of lowering blood sugar, tonifying the kidney and strengthening yang, lowering blood pressure, lowering blood lipids, anti-aging, calming the mind, reducing the side effects after tumor chemotherapy, promoting blood circulation and removing blood stasis, preventing cerebral thrombosis, strengthening the spleen and promoting digestion, etc.

[0025] 2. Drinking the Ganoderma Lucidum oral liquid in moderation can increase the number of white blood cells and the total number of macrophages in the body, reduce the necrosis of normal cells, prolong the life cycle of cells, enhance the vitality of cells, increase the number of white blood cells and the total number of macrophages in the body, resist the invasion of foreign substances, and thus reduce the risk of cell canceration.

[0026] 3. The Ganoderma Lucidum oral liquid prepared by the present invention has a good inhibitory effect on local inflammation in lung tissue and helps maintain the health of the respiratory system. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for describing the embodiments are briefly introduced below.

[0028] Figure 1 The present invention is a flow chart of a Lingzhi oral liquid containing bamboo leaf flavonoids and red yeast rice. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present invention are described below. The described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments.

[0030] Example 1

[0031] A meat ganoderma oral liquid containing bamboo leaf flavonoids and red yeast rice, comprising the following raw materials in parts by weight: 850 parts of meat ganoderma, 200 parts of ginseng, 90 parts of cordyceps militaris, 30 parts of codonopsis pilosula, 30 parts of dendrobium candidum, 400 parts of bamboo leaf flavonoids, 100 parts of red yeast rice, 30 parts of tremella, 80 parts of yam, 30 parts of mulberry, 100 parts of angelica, 200 parts of spiny jujube seeds, 29 parts of honey, 300 parts of astragalus and 28 parts of tuckahoe;

[0032] The preparation process includes the following steps:

[0033] S1: Cleaning process: Clean the Ganoderma lucidum for 20 minutes to remove impurities, microorganisms, etc. attached to its surface and create a clean environment for subsequent fermentation;

[0034] S2: Ganoderma lucidum fermentation process: under suitable conditions of temperature at 27-32°C, relative humidity at 60%, and pH at 7.2, the cleaned Ganoderma lucidum is added to a specific culture solution and the "AHCC" spore complex is added for 20 days of fermentation. During this process, Ganoderma lucidum releases its own active ingredients under the action of the specific environment and the "AHCC" spore complex, and at the same time cooperates with the "AHCC" spore complex to improve the quality and efficacy of the fermentation product;

[0035] S3: Red yeast rice pretreatment process: first soak the red yeast rice in cold boiled water for 3-5 hours to allow it to fully absorb water and swell, then place the soaked red yeast rice in an environment of 30-40°C for 2-3 days for fermentation, and after the fermentation is completed, seal the jar and set aside. This step allows the microorganisms in the red yeast rice to fully reproduce and metabolize, producing beneficial components of red yeast pigment;

[0036] S4: Bamboo leaf flavonoid extraction process: the bamboo leaves are crushed, and then an appropriate amount of organic solvent is added and soaked for 1 day to fully dissolve the flavonoids in the bamboo leaves in the organic solvent. After the soaking, a filtrate is obtained by filtering, and the filtrate is concentrated and dried to finally obtain a bamboo leaf flavonoid extract;

[0037] S5: Mixed fermentation and filling process: Add the prepared bamboo leaf flavonoids extract, fermented Monascus and specially formulated Chinese medicine auxiliary powder into a culture tank and ferment them under suitable environmental conditions for 10 days. After the fermentation is completed, the finished product is aseptically filled into pre-sterilized bottles.

[0038] Clinical Validation

[0039] 30 different patients with various middle and late stage cancers accompanied by deficiency of both qi and yin or deficiency of both qi and blood in traditional Chinese medicine were selected for trial use. This example was applied to the above patients twice a day; the white blood cell count (WBC) and classification, hemoglobin (Hb) and other indicators were tested and recorded once every 10 days; 30 days was a course of treatment, and all data were statistically processed using t-test. The patient recovery status is as follows:

[0040] Efficacy criteria:

[0041] Markedly effective: After stopping chemotherapy drugs and taking Ganoderma Lucidum oral liquid for one month, WBC count and classification returned to the normal range, >5.0*109 / L or increased from 2.0*109 / L to above 4.0*109 / L, and maintained for more than 2 weeks.

[0042] Effective: WBC count increased by 100% or rose to 3.0*109 / L compared with before treatment and maintained above 2 weeks.

[0043] Ineffective: After treatment, WBC did not increase significantly.

[0044] Significant effect efficient invalid total n 17 10 3 30 ％ 56.67％ 33.33％ 10％ 100％

[0045] Table 1

[0046] Clinically, it is shown that oral liquid of Ganoderma lucidum with flavonoids and red yeast rice has a total effective rate of 90% and a significant effective rate of 56.67% for treating WBC deficiency after radiotherapy and chemotherapy for tumors, indicating that oral liquid of Ganoderma lucidum can significantly increase the total white blood cell count.

[0047] Example 2

[0048] A meat ganoderma oral liquid containing bamboo leaf flavonoids and red yeast rice, which is composed of the following raw materials in parts by weight: 850 parts of meat ganoderma, 200 parts of ginseng, 90 parts of cordyceps militaris, 30 parts of codonopsis pilosula, 29 parts of dendrobium candidum, 400 parts of bamboo leaf flavonoids, 100 parts of red yeast rice, 28 parts of tremella, 80 parts of yam, 30 parts of mulberry, 100 parts of angelica, 200 parts of spiny jujube seeds, 29 parts of honey, 300 parts of astragalus and 31 parts of tuckahoe;

[0049] The preparation process includes the following steps:

[0050] S1: Cleaning process: Clean the Ganoderma lucidum for 20 minutes to remove impurities, microorganisms, etc. attached to its surface and create a clean environment for subsequent fermentation;

[0051] S2: Ganoderma lucidum fermentation process: under suitable conditions of temperature at 27-32°C, relative humidity at 60%, and pH at 7.2, the cleaned Ganoderma lucidum is added to a specific culture solution and the "AHCC" spore complex is added for 20 days of fermentation. During this process, Ganoderma lucidum releases its own active ingredients under the action of the specific environment and the "AHCC" spore complex, and at the same time cooperates with the "AHCC" spore complex to improve the quality and efficacy of the fermentation product;

[0052] S3: Red yeast rice pretreatment process: first soak the red yeast rice in cold boiled water for 3-5 hours to allow it to fully absorb water and swell, then place the soaked red yeast rice in an environment of 30-40°C for 2-3 days for fermentation, and after the fermentation is completed, seal the jar and set aside. This step allows the microorganisms in the red yeast rice to fully reproduce and metabolize, producing beneficial components of red yeast pigment;

[0053] S4: Bamboo leaf flavonoid extraction process: the bamboo leaves are crushed, and then an appropriate amount of organic solvent is added and soaked for 1 day to fully dissolve the flavonoids in the bamboo leaves in the organic solvent. After the soaking, a filtrate is obtained by filtering, and the filtrate is concentrated and dried to finally obtain a bamboo leaf flavonoid extract;

[0054] S5: Mixed fermentation and filling process: Add the prepared bamboo leaf flavonoids extract, fermented Monascus and specially formulated Chinese medicine auxiliary powder into a culture tank and ferment them under suitable environmental conditions for 10 days. After the fermentation is completed, the finished product is aseptically filled into pre-sterilized bottles.

[0055] Clinical Validation

[0056] 30 different patients with various middle and late stage cancers accompanied by deficiency of both qi and yin or deficiency of both qi and blood in traditional Chinese medicine were selected for trial use. This example was applied to the above patients twice a day; the white blood cell count (WBC) and classification, hemoglobin (Hb) and other indicators were tested and recorded once every 10 days; 30 days was a course of treatment, and all data were statistically processed using t-test. The patient recovery status is as follows:

[0057]

[0058]

[0059] Table 2

[0060] Clinically, it is shown that Lingzhi oral liquid with flavonoids and red yeast rice can increase the total white blood cell count of tumor patients. From the perspective of classification, the effect is not significant. It can also increase the hemoglobin content of patients. After statistical testing, there is a significant difference.

[0061] Example 3

[0062] A meat ganoderma oral liquid containing bamboo leaf flavonoids and red yeast rice, which is composed of the following raw materials in parts by weight: 850 parts of meat ganoderma, 200 parts of ginseng, 90 parts of cordyceps militaris, 31 parts of codonopsis pilosula, 30 parts of dendrobium candidum, 400 parts of bamboo leaf flavonoids, 100 parts of red yeast rice, 30 parts of tremella, 80 parts of yam, 34 parts of mulberry, 100 parts of angelica, 200 parts of spiny jujube seeds, 31 parts of honey, 300 parts of astragalus and 32 parts of tuckahoe;

[0063] The preparation process includes the following steps:

[0064] S1: Cleaning process: Clean the Ganoderma lucidum for 20 minutes to remove impurities, microorganisms, etc. attached to its surface and create a clean environment for subsequent fermentation;

[0065] S2: Ganoderma lucidum fermentation process: under suitable conditions of temperature at 27-32°C, relative humidity at 60%, and pH at 7.2, the cleaned Ganoderma lucidum is added to a specific culture solution and the "AHCC" spore complex is added for 20 days of fermentation. During this process, Ganoderma lucidum releases its own active ingredients under the action of the specific environment and the "AHCC" spore complex, and at the same time cooperates with the "AHCC" spore complex to improve the quality and efficacy of the fermentation product;

[0066] S3: Red yeast rice pretreatment process: first soak the red yeast rice in cold boiled water for 3-5 hours to allow it to fully absorb water and swell, then place the soaked red yeast rice in an environment of 30-40°C for 2-3 days for fermentation, and after the fermentation is completed, seal the jar and set aside. This step allows the microorganisms in the red yeast rice to fully reproduce and metabolize, producing beneficial components of red yeast pigment;

[0067] S4: Bamboo leaf flavonoid extraction process: the bamboo leaves are crushed, and then an appropriate amount of organic solvent is added and soaked for 1 day to fully dissolve the flavonoids in the bamboo leaves in the organic solvent. After the soaking, a filtrate is obtained by filtering, and the filtrate is concentrated and dried to finally obtain a bamboo leaf flavonoid extract;

[0068] S5: Mixed fermentation and filling process: Add the prepared bamboo leaf flavonoids extract, fermented Monascus and specially formulated Chinese medicine auxiliary powder into a culture tank and ferment them under suitable environmental conditions for 10 days. After the fermentation is completed, the finished product is aseptically filled into pre-sterilized bottles.

[0069] Clinical Validation

[0070] 30 different patients with various middle and late stage cancers accompanied by deficiency of both qi and yin or deficiency of both qi and blood in traditional Chinese medicine were selected for trial use. This example was applied to the above patients twice a day; the white blood cell count (WBC) and classification, hemoglobin (Hb) and other indicators were tested and recorded once every 10 days; 30 days was a course of treatment, and all data were statistically processed using t-test. The patient recovery status is as follows:

[0071]

[0072]

[0073] Table 3

[0074] Clinically, it is shown that oral liquid of Ganoderma lucidum with flavonoids and red yeast rice can improve the main symptoms of deficiency syndrome, with an average improvement of more than 50%. Statistics show that p<0.01 or p<0.001.

[0075] Example 4

[0076] A meat ganoderma oral liquid containing bamboo leaf flavonoids and red yeast rice, which is composed of the following raw materials in parts by weight: 850 parts of meat ganoderma, 200 parts of ginseng, 90 parts of cordyceps militaris, 31 parts of codonopsis pilosula, 30 parts of dendrobium candidum, 400 parts of bamboo leaf flavonoids, 100 parts of red yeast rice, 30 parts of tremella, 80 parts of yam, 34 parts of mulberry, 100 parts of angelica, 200 parts of spiny jujube seeds, 31 parts of honey, 300 parts of astragalus and 32 parts of tuckahoe;

[0077] The preparation process includes the following steps:

[0078] S1: Cleaning process: Clean the Ganoderma lucidum for 20 minutes to remove impurities, microorganisms, etc. attached to its surface and create a clean environment for subsequent fermentation;

[0079] S2: Ganoderma lucidum fermentation process: under suitable conditions of temperature at 27-32°C, relative humidity at 60%, and pH at 7.2, the cleaned Ganoderma lucidum is added to a specific culture solution and the "AHCC" spore complex is added for 20 days of fermentation. During this process, Ganoderma lucidum releases its own active ingredients under the action of the specific environment and the "AHCC" spore complex, and at the same time cooperates with the "AHCC" spore complex to improve the quality and efficacy of the fermentation product;

[0080] S3: Red yeast rice pretreatment process: first soak the red yeast rice in cold boiled water for 3-5 hours to allow it to fully absorb water and swell, then place the soaked red yeast rice in an environment of 30-40°C for 2-3 days for fermentation, and after the fermentation is completed, seal the jar and set aside. This step allows the microorganisms in the red yeast rice to fully reproduce and metabolize, producing beneficial components of red yeast pigment;

[0081] S4: Bamboo leaf flavonoid extraction process: the bamboo leaves are crushed, and then an appropriate amount of organic solvent is added and soaked for 1 day to fully dissolve the flavonoids in the bamboo leaves in the organic solvent. After the soaking, a filtrate is obtained by filtering, and the filtrate is concentrated and dried to finally obtain a bamboo leaf flavonoid extract;

[0082] S5: Mixed fermentation and filling process: Add the prepared bamboo leaf flavonoids extract, fermented Monascus and specially formulated Chinese medicine auxiliary powder into a culture tank and ferment them under suitable environmental conditions for 10 days. After the fermentation is completed, the finished product is aseptically filled into pre-sterilized bottles.

[0083] Clinical Validation

[0084] 35 patients with different types of bone tumors were selected for trial use. This example was applied to the above patients, 3 times a day for 30 consecutive days, and the classification of T cell subpopulations, NK cell activity, macrophage function, etc. were detected. The specific results are as follows:

[0085]

[0086] Table 4

[0087]

[0088] Table 5

[0089]

[0090] Table 6

[0091] Clinically, it is shown that Lingzhi oral liquid containing flavonoids and red yeast rice has improved certain immune indicators, among which it has no obvious promoting effect on macrophage phagocytosis rate, killing rate, NK cell activity and T cell subsets CD3, CD4, CD8, etc. in patients with malignant bone tumors. However, CD4 / CD8 ratio and macrophage phagocytosis index have increased significantly. At the same time, various toxic and side effects have not been found in clinical applications, and it can be used as an auxiliary drug for immunotherapy.

[0092] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that technicians in the relevant technical field can better understand and utilize the present invention.

Claims

1. A meat ganoderma oral liquid containing bamboo leaf flavonoids and red yeast rice, characterized in that: The raw materials include the following parts by weight: 850-950 parts of Ganoderma lucidum, 95-105 parts of red yeast rice, 350-450 parts of bamboo leaf flavonoids and appropriate amount of Chinese medicine auxiliary material powder; The preparation process includes the following steps: S1: Wash the Ganoderma lucidum for 20 minutes; S2: Add Ganoderma lucidum to the culture solution and add "AHCC" spore complex under the conditions of temperature 27-32°C, relative humidity 60%, and pH 7.2, and ferment for 20 days; S3: Soak the red yeast rice in cold boiled water for 3-5 hours, ferment it at 30-40°C for 2-3 days, and store it in a jar for later use; S4: crushing the bamboo leaves, adding an appropriate amount of organic solvent, soaking for 1 day and then filtering, concentrating and drying the filtrate to obtain the bamboo leaf flavonoid extract; S5: Add bamboo leaf flavonoids extract, Monascus and Chinese medicine auxiliary powder into a culture tank and ferment for 10 days. After the fermentation is completed, put the finished product into sterilized bottles.

2. The oral liquid of Ganoderma lucidum containing bamboo leaf flavonoids and red yeast rice according to claim 1, characterized in that: The Chinese medicine auxiliary material powder is prepared from the following raw materials in parts by weight: 150-250 parts of ginseng, 90-100 parts of cordyceps militaris, 28-32 parts of codonopsis pilosula, 25-35 parts of dendrobium officinale, 25-35 parts of tremella, 75-85 parts of yam, 25-35 parts of mulberry, 95-105 parts of angelica, 190-210 parts of spiny jujube seeds, 28-32 parts of honey, 290-310 parts of astragalus and 25-35 parts of poria.

3. The oral liquid of Ganoderma lucidum containing bamboo leaf flavonoids and red yeast rice according to claim 2, characterized in that: The specific weight portions of the Chinese medicine auxiliary material powder are: 200 parts of ginseng, 95 parts of cordyceps militaris, 30 parts of codonopsis pilosula, 28 parts of dendrobium officinale, 30 parts of tremella, 80 parts of yam, 30 parts of mulberry, 100 parts of angelica, 200 parts of spinach seed, 30 parts of honey, 300 parts of astragalus and 30 parts of poria.

4. The oral liquid of Ganoderma lucidum containing bamboo leaf flavonoids and red yeast rice according to claim 1, characterized in that: The preparation of the Chinese medicine auxiliary material powder comprises the following steps: Step 1: Screen and classify the Chinese medicines, clean each Chinese medicine except honey after classification, cut the cleaned Chinese medicines into sections or pieces, and dry them in the sun or in an oven; Step 2: Take a specific weight portion of Chinese medicine auxiliary material, add honey without adding water, grind it to a mesh size of 80-100, and sieve it to obtain Chinese medicine auxiliary material powder.

5. The oral liquid of Ganoderma lucidum containing bamboo leaf flavonoids and red yeast rice according to claim 1, characterized in that: The preparation method of the AHCC spore complex is as follows: after culturing the strain at 24-28° C. and pH 5.5-6.5, cellulase and protease are used to decompose the mycelium cell wall to release the intracellular active ingredients, vacuum low-temperature concentration is performed to retain the heat-sensitive active substances, and finally ultrafiltration technology is used to intercept the target molecular weight range.

6. The oral liquid of Ganoderma lucidum containing bamboo leaf flavonoids and red yeast rice according to claim 5, characterized in that: The AHCC spore complex is made of shiitake mushrooms.

7. The oral liquid of Ganoderma lucidum containing bamboo leaf flavonoids and red yeast rice according to claim 1, characterized in that: The organic solvent is ethanol or methanol.

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