Composition with effects of removing dandruff, relieving itching, controlling oil and protecting hair

Abstract

The invention provides a composition with dandruff-removing, itching-relieving, oil-controlling and hair-protecting effects, and belongs to the technical field of hair cosmetics and biological medicines. The composition is prepared from zinc ricinoleate, sophocarpidine and trehalose according to the mass ratio of (1 to 50) to (1 to 15) to (1 to 15). The zinc ricinoleate in the composition disclosed by the invention is a safe and environment-friendly molecule which is environment-friendly and is obtained from renewable resources; the matrine is natural extract alkaloid; the trehalose is also natural disaccharide. The combination of the ricinoleic acid zinc grease, the sophocarpidine and the trehalose combines the hair effects of natural active zinc inorganic molecules, alkaloid organic molecules and natural marine sugar molecules, and has the remarkable effects of removing dandruff, relieving itching, controlling oil and caring scalp. The shampoo and the hair conditioner prepared from the composition have the remarkable effects of conditioning, softening and brightening hair, preventing hair loss, nourishing hair, resisting allergy, relieving and removing peculiar smell of hair, are outstanding in effect, safe to use and free of irritation, and have a good application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of hair cosmetics and biomedicine, and particularly relates to a composition with the functions of removing dandruff, relieving itching, controlling oil and protecting hair. Background Art

[0002] As people's living standards improve, they pay more and more attention to their personal image. As basic personal care products, shampoo and hair care products are indispensable in people's daily lives and are widely concerned and demanded by people. Under the fast-paced and high-pressure lifestyle, oily hair, dandruff and itchy scalp are plaguing people's lives.

[0003] Commonly used anti-dandruff and antipruritic agents on the market include piroctone ethanolamine (OCT), zinc pyrithione (ZPT), climbazole (oxadiazole), salicylic acid, antifungal drugs such as ketoconazole, etc., which reduce the growth of scalp microorganisms and inhibit the division of scalp keratinocytes, thereby achieving the purpose of dandruff removal. However, long-term use of such drugs is prone to drug resistance and has a large irritation to the scalp. ZPT, the most widely used anti-dandruff and antipruritic agent, has certain toxicity and irritation, and there are safety risks. People are more inclined to choose natural and safe products to avoid damage to the scalp and hair.

[0004] In the prior art, there is a lack of products that are derived from nature and have good anti-dandruff, anti-itching, oil control and hair care effects. Summary of the invention

[0005] The purpose of the present invention is to provide a composition with anti-dandruff, anti-itching, oil-controlling and hair-care functions. The anti-dandruff, anti-itching, oil-controlling and hair-care functions are remarkable, the raw materials are derived from natural products, and the composition is safe and non-irritating.

[0006] The purpose of the present invention is achieved by the following technical solutions:

[0007] A composition with the functions of removing dandruff, relieving itching, controlling oil and protecting hair is composed of zinc ricinoleate, matrine and trehalose in a mass ratio of 1-50:1-15:1-15.

[0008] In the preferred technical solution, the mass ratio of zinc ricinoleate, matrine and trehalose is 1:0.5-1.5:0.5-1.5.

[0009] In the preferred technical solution, the mass ratio of zinc ricinoleate, matrine and trehalose is 1:1:1.

[0010] In the present invention, the ricinoleate zinc grease is obtained by activating ricinoleate zinc with arginine, wherein the active zinc content is greater than 5000 ppm.

[0011] In the present invention, the matrine is extracted from the root of Sophora flavescens and dried, wherein the content of matrine is greater than 10%.

[0012] The present invention also provides a skin external preparation containing the composition.

[0013] In the present invention, the skin external preparation includes shampoo, conditioner, hair liquid, shampoo and hair conditioner gel, and leave-in conditioner.

[0014] In the present invention, the external skin preparation further includes a cosmetic raw material or a drug excipient.

[0015] The composition of the present invention can be mixed with shampoo and hair care raw materials or excipients to prepare an external hair preparation, which has the effects of removing dandruff, relieving itching, controlling oil, protecting scalp, conditioning, softening, shining hair, and removing hair odor; it has the characteristics of significant shampoo and hair care efficacy, long-lasting maintenance, and safe use.

[0016] Compared with the prior art, the present invention has the following characteristics: the ricinoleic acid zinc grease in the composition of the present invention is a safe and environmentally friendly molecule obtained from renewable resources, which is friendly to the environment; matrine is a natural extract alkaloid; and trehalose is also a natural disaccharide. The combination of ricinoleic acid zinc grease, matrine and trehalose combines the hair effects of natural active zinc inorganic molecules, alkaloid organic molecules and natural marine sugar molecules, and has significant effects of removing dandruff, relieving itching, controlling oil and caring for scalp. In addition, the shampoo and conditioner prepared by the composition of the present invention have significant effects of conditioning, softening, shining hair, preventing hair loss and promoting hair growth, anti-allergic and soothing, and removing hair odor, with outstanding efficacy, safe and non-irritating use, and good application prospects. DETAILED DESCRIPTION

[0017] The present invention will be further described below in conjunction with embodiments.

[0018] C162: Cationic guar gum, content 99%.

[0019] JR30M: Polyquaternium-10, content 98%.

[0020] CAB35: cocamidopropyl betaine, active matter content 35%, purchased from Guangzhou Suixin Chemical Co., Ltd.

[0021] AES (30%): sodium fatty alcohol polyoxyethylene ether sulfate, active matter content 30%, purchased from Linyi Lvsen Chemical Co., Ltd.

[0022] 6501: Coconut oil diethanolamide, content 95%.

[0023] M550: Polyquaternium-7, content 99%.

[0024] Example 1

[0025] The composition A with the functions of removing dandruff, relieving itching, controlling oil and protecting hair is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 1:1:1.

[0026] The preparation method of ricinoleic acid zinc grease is as follows: 100g of ricinoleic acid zinc and 1000g of water are added to a reaction kettle, heated to 60°C and kept warm under stirring, 100g of arginine is added as an amino acid activation auxiliary agent, and stirring is continued for 1 hour; impurities are filtered to remove, the filtrate is collected, and cooled to room temperature to obtain ricinoleic acid zinc grease. The properties of ricinoleic acid zinc grease are as follows: slightly yellow clear liquid, slightly sticky like grease, with a characteristic odor of castor oil, and soluble in water. The active zinc content in ricinoleic acid zinc grease is determined by spectrophotometry, which is 32610ppm.

[0027] The extraction method of matrine powder is as follows: crush the root of Sophora flavescens (particle size 100 mesh), extract it by ultrasonic assisted alcohol extraction, heat and reflux extract it with 65% ethanol aqueous solution by volume percentage for 2 times, in each extraction, the solid-liquid ratio is 1:18 (1g of crushed Sophora flavescens root is added with 18mL 65% ethanol aqueous solution by volume percentage), the extraction time is 1 hour, and the extraction temperature is 40°C. Combine the extracts, recover ethanol by rotary evaporator and concentrate to 1 / 4 of the original extract volume, add it to AB-8 macroporous adsorption resin, elute it with 75% ethanol aqueous solution by volume percentage, collect the eluate, concentrate it by rotary evaporator under reduced pressure, vacuum dry it (temperature 45°C, pressure 2kPa), weigh it, obtain matrine powder with a particle size of 100 mesh, and determine the content of matrine (mg / g). The properties of matrine powder are as follows: extremely light yellow powder, odorless, bitter, hygroscopic, soluble in water and ethanol. Determination of matrine powder content: The phthalic acid-bromocresol green colorimetric method was used to determine the content of matrine in the sophora flavescens extract. The matrine content of this product is 503.25 mg / g.

[0028] The matrine powder extraction process and content determination method are well-known and commonly used methods.

[0029] Trehalose powder (particle size: 100 mesh) was purchased from Dezhou Huiyang Biotechnology Co., Ltd., with a content of 99.5%.

[0030] The preparation method of shampoo A is as follows: Prepare phase A: add 2g C162, 2g JR30M and 0.3g citric acid to 570.7g deionized water in sequence and stir evenly. Prepare phase B: mix 3530g CAB, 330g AES (30%) and 110g 650 and stir evenly. Prepare phase C: mix 10g water-soluble olive oil and 10g M550 and stir evenly. Add phase B to phase A and stir evenly, then add phase C and stir evenly, then add 15g composition A and stir evenly, and finally add 20g sodium chloride and stir evenly to thicken, and obtain 1000g shampoo, containing 15g composition A, specifically, 5g ricinoleic acid zinc grease, 5g matrine, and 5g trehalose.

[0031] The preparation method of conditioner A is as follows: prepare phase A: take 830g of deionized water, 20g of hexadecyltrimethylammonium chloride and 15g of composition A, mix them, and heat them to 80°C under stirring to obtain a uniform phase. Prepare phase B: take 70g of hexadecanol, 30g of glyceryl monostearate and 35g of isopropyl palmitate, mix them, and heat them to 80°C under stirring to obtain a uniform phase. Add phase B to phase A at 80°C, emulsify under stirring, and then homogenize with a homogenizer to obtain 1000g of conditioner A, containing 5g of ricinoleic acid zinc grease, 5g of matrine and 5g of trehalose. Wherein, stirring and homogenizing are both carried out at 80°C.

[0032] In addition, a control shampoo was prepared according to the preparation method of shampoo A, except that 15 g of composition A in shampoo A was replaced with the substances in Table 1, to obtain a corresponding control shampoo. A control conditioner was prepared according to the preparation method of conditioner A, except that 15 g of composition A in conditioner A was replaced with the substances in Table 2, to obtain a corresponding control conditioner.

[0033] Table 1 Composition of control shampoo

[0034]

[0035] Table 2 Composition of control conditioner

[0036]

[0037]

[0038] Example 2

[0039] The composition B with anti-dandruff, anti-itching, oil-controlling and hair-care functions is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 1:5:1.

[0040] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 15g of Composition A was replaced by a mixture of 14g of Composition B and 1g of deionized water, and the rest remained unchanged to prepare 1000g of the corresponding shampoo and conditioner.

[0041] Example 3

[0042] The composition C with anti-dandruff, anti-itching, oil-controlling and hair-care functions is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 10:1:1.

[0043] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 15g of Composition A was replaced by a mixture of 12g of Composition C and 3g of deionized water, and the rest remained unchanged to prepare 1000g of the corresponding shampoo and conditioner.

[0044] Example 4

[0045] The composition D having the functions of removing dandruff, relieving itching, controlling oil and protecting hair is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 1:2:2.

[0046] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 15 g of Composition A was replaced with 15 g of Composition D, and the other conditions remained unchanged to prepare 1000 g of the corresponding shampoo and conditioner.

[0047] Example 5

[0048] The composition E with anti-dandruff, anti-itching, oil-controlling and hair-care functions is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 2:1:1.

[0049] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 20 g of Composition E was used to replace 15 g of Composition A, and the other parts remained unchanged to prepare 1005 g of the corresponding shampoo and conditioner.

[0050] Example 6

[0051] The composition F with anti-dandruff, anti-itching, oil-controlling and hair-care functions is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 1:5:10.

[0052] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 16 g of Composition F was used to replace 15 g of Composition F, and the other parts remained unchanged to prepare 1001 g of the corresponding shampoo and conditioner.

[0053] Example 7

[0054] The composition G with anti-dandruff, anti-itching, oil-controlling and hair-care functions is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 1:5:20.

[0055] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 26 g of Composition G was used to replace 15 g of Composition A, and 1011 g of the corresponding shampoo and conditioner were prepared without changing other matters.

[0056] Example 8

[0057] The composition H having the functions of removing dandruff, relieving itching, controlling oil and protecting hair is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 50:1:1.

[0058] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 15 g of Composition A was replaced with 15 g of Composition H, and the other conditions remained unchanged to prepare 1000 g of the corresponding shampoo and conditioner.

[0059] Example 9

[0060] The composition I with anti-dandruff, antipruritic, oil-control and hair care functions is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 1:10:10.

[0061] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 15 g of Composition I was used to replace 15 g of Composition A, and other conditions remained unchanged to prepare 1000 g of the corresponding shampoo and conditioner.

[0062] Example 10

[0063] The composition J with anti-dandruff, anti-itching, oil-controlling and hair-care functions is obtained by uniformly mixing ricinoleic acid zinc grease, matrine powder and trehalose powder in a mass ratio of 1:10:5.

[0064] According to the preparation method of Shampoo A and Conditioner A in Example 1, only 16 g of Composition J was used to replace 15 g of Composition A, and the rest remained unchanged to prepare 1001 g of the corresponding shampoo and conditioner.

[0065] Example 11 Effect Verification

[0066] The shampoo A and conditioner A prepared in Example 1, the control shampoo in Table 1, and the control conditioner in Table 2 were subjected to relevant efficacy tests and local irritation safety evaluation experiments.

[0067] 1. Efficacy test - antibacterial experiment

[0068] The anti-dandruff and antibacterial effects of shampoo A containing composition A were studied. It is currently believed that the cause of dandruff is the excessive proliferation of microorganisms, mainly Malassezia and Staphylococcus, and excessive secretion of scalp oil. Therefore, the antibacterial effects of shampoo A containing composition A and the control shampoo in Table 1 on three typical representative bacteria of scalp infection, Malassezia furfur, Candida albicans, and Staphylococcus epidermidis, were determined by an in vitro antibacterial method. Referring to the National Standard of the People's Republic of China QB / T2738-2023—"Evaluation Method for Antibacterial and Antibacterial Effects of Daily Chemical Products", the inhibitory effects of each shampoo on Malassezia furfur, Staphylococcus epidermidis, and Candida albicans were determined through antibacterial tests.

[0069] The specific method of the antibacterial test of Malassezia furfur, Staphylococcus epidermidis and Candida albicans was carried out on Shampoo A and the control shampoo in Table 1: 1 g of shampoo was added with 0.1 mL of bacterial suspension (concentration of 10 6 cfu / mL), mix evenly, add 9mL PBS buffer (pH7.2) after 20min, mix thoroughly, dilute appropriately, take 2-3 dilutions, take 1mL respectively and place in two parallel plates, then add the culture medium of the corresponding bacteria, mix and culture. Malassezia furfur was cultured at 30℃ for 4d, Staphylococcus epidermidis was cultured at 37℃ for 48h, and Candida albicans was cultured at 28℃ for 72h, colony counts were made, and the inhibition rate was calculated. The test was repeated 3 times, and the average inhibition rate was calculated.

[0070] The experimental results are shown in Table 3. The higher the antibacterial rate, the better the antibacterial and anti-dandruff effect of the product. Among them, Malassezia furfur uses Malassezia culture medium, Staphylococcus epidermidis uses LB culture medium, and Candida albicans uses Sabouraud glucose agar culture medium.

[0071] Table 3 Antibacterial effect of shampoo A and control shampoo

[0072]

[0073] The results showed that shampoo A containing composition A had significant inhibitory effects on bacteria (Staphylococcus epidermidis) and fungi (Malassezia furfur and Candida albicans), and was superior to the control shampoos.

[0074] 2. Efficacy test --- Evaluation of the oil control effect of shampoo A containing composition A

[0075] 240 volunteers, aged 20-50 years old, 120 males and 120 females, were recruited. They were randomly divided into 8 groups, 30 people in each group (half males and half females). A half-head test was conducted in an environment with a temperature of 20°C and a relative humidity of 50%, i.e., the left side of each person's hair was treated with Shampoo A in Example 1 or each control shampoo in Table 1, and the right side was not treated with any shampoo as a blank control. At 0, 1, 4, 24, and 48 hours after shampooing, the scalp oil content of each shampoo and the blank control was measured using a scalp oil tester. The measurement was performed three times and the average value was taken. The oil control rate was calculated according to the oil control rate = (blank control scalp oil content - experimental group scalp oil content) / blank control scalp oil content * 100%.

[0076] The experimental results are shown in Table 4. The results show that within the test period, after the test sample was used in the test area, Shampoo A containing Composition A had a significant inhibitory effect on the scalp oil content and had a significant oil control effect; and the effect was maintained for a long time, which was better than the control shampoos.

[0077] Table 4 Oil control effect of shampoo A and control shampoo (oil control rate / %)

[0078]

[0079]

[0080] 3. Efficacy test - Evaluation of the anti-dandruff and antipruritic effect of shampoo A containing composition A

[0081] Evaluation of anti-dandruff and antipruritic effects: 240 volunteers with dandruff and itchy scalp were selected, aged 20-45 years old, 120 men and 120 women. They were randomly divided into 8 groups, each with 30 people (half men and half women), and their hair was washed with Shampoo A in Example 1 or the control shampoos in Table 1. According to the group standard "Test Method for Anti-dandruff Efficacy of Anti-dandruff Products" (T / GDCA 010-2022), the symptoms of dandruff and itchy scalp were compared before and after use. The anti-dandruff effect was effective, and the no anti-dandruff effect was ineffective. The effective and ineffective numbers were counted.

[0082] The evaluation results of the anti-dandruff and anti-itching effects are shown in Table 5. As can be seen from Table 5, Shampoo A containing Composition A has a more significant effect on dandruff and itching, and the subjects felt that the dandruff symptoms were significantly alleviated or disappeared, and believed that Shampoo A had an outstanding anti-dandruff and anti-itching effect. The trial results also showed that the shampoo containing Composition A is mild, safe, and low in irritation.

[0083] Table 5 Evaluation of the antidandruff and antipruritic effects of Shampoo A and Control Shampoo

[0084]

[0085] 4. Efficacy test - Evaluation of the hair care effect of conditioner A containing composition A

[0086] 240 volunteers who subjectively felt that their hair was prone to falling off after shampooing were selected, aged 20-45 years old, 120 men and 120 women. They were randomly divided into 8 groups, each with 30 people (half men and half women), and the conditioner A in Example 1 or the control conditioners in Table 2 were applied to the scalp of the volunteers in a combing manner. After the entire scalp was covered, they were evenly massaged by hand and rinsed. Use it once every other day for 7 consecutive days. According to the "Technical Specifications for Safety of Cosmetics-Test Methods for the Anti-Hair Loss Efficacy of Cosmetics" (issued by the State Food and Drug Administration on March 2, 2021), the symptoms of easy hair falling off after shampooing were compared before and after use. Those with anti-hair loss efficacy are effective, and those with anti-hair loss efficacy are ineffective. The number of effective and ineffective people are counted.

[0087] The trial effect was evaluated, and the trial situation after continuous use of the present invention for 7 days was compared and compared. The evaluation results are shown in Table 6. As can be seen from Table 6, after continuous use for 7 days, compared with the control conditioner, the conditioner A containing composition A has a more significant effect on the subjects whose hair is easy to fall off after shampooing. The subjects feel that the anti-hair loss effect is outstanding and has a significant hair care effect. The trial results also show that the conditioner A containing composition A is mild, safe and low in irritation.

[0088] Table 6 Evaluation of the hair care effects of Conditioner A and Control Conditioner

[0089]

[0090] 5. Local irritation test

[0091] Eight adult rabbits were selected, half male and half female, and each animal was housed in a separate cage and kept in laboratory conditions for 3-4 days. Then the hair on both sides of the rabbit spine was shaved with an electric shaver, with an area of ​​5×10 cm on each side. 2 . Carefully check whether there is redness, swelling and damage in the hair removal area. If there is any, it should be discarded and cannot be tested. Use the test method of multiple administration, apply shampoo A containing composition A or conditioner A containing composition A to the hair removal area, twice a day, apply evenly to the hair removal area each time, and apply continuously for 7 days. Wash off the smear with warm water 24 hours after the last application, and observe local skin reactions such as erythema, edema, desquamation, scab, etc., whether there are bleeding spots, rough or thin skin peptides, etc., after 1, 24, 48, and 72 hours respectively, and record the occurrence time and disappearance time.

[0092] The experimental results show that after continuous application of shampoo A or conditioner A containing composition A for 7 days, the skin of each rabbit showed no obvious skin irritation and allergic reaction. The above results show that the composition A, shampoo A and conditioner A are safe, have no adverse reactions, are non-toxic and non-irritating. Moreover, the in vitro red blood cell hemolysis test proves that it is milder, safer and less irritating than the commercially available scalp care solution containing chemical anti-dandruff ingredients.

Claims

1. A composition having anti-dandruff, antipruritic, oil-controlling and hair-care effects, characterized in that: The invention is composed of ricinoleic acid zinc ester, matrine and trehalose in a mass ratio of 1-50:1-15:1-15.

2. The composition according to claim 1, characterized in that The mass ratio of zinc ricinoleate, matrine and trehalose is 1:0.5-1.5:0.5-1.

5.

3. The composition according to claim 2, characterized in that The mass ratio of zinc ricinoleate, matrine and trehalose is 1:1:

1.

4. A composition according to any one of claims 1 to 3, characterized in that The ricinoleate zinc grease is obtained by activating ricinoleate zinc with arginine, wherein the active zinc content is greater than 5000 ppm.

5. The composition according to claim 4, characterized in that The matrine is extracted from the root of Sophora flavescens and dried, wherein the content of matrine is greater than 10%.

6. A skin external preparation comprising the composition according to any one of claims 1 to 5.

7. The hair shampoo and hair care product according to claim 6, characterized in that The skin external preparations include shampoo, hair conditioner, hair liquid, shampoo and hair conditioner gel, and leave-in conditioner.

8. The hair shampoo and hair care product according to claim 7, characterized in that The external skin preparation may further include cosmetic raw materials or excipients for drugs.

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