Traditional Chinese medicine lipstick for treating chronic cheilitis and preparation method thereof

Abstract

The invention belongs to the technical field of lipsticks, and particularly provides a traditional Chinese medicine lipstick for treating chronic cheilitis and a preparation method thereof. The coconut oil, the licorice extract, the sweet almond oil, the peach kernel oil (also called peach kernel oil), the sweet almond oil, the wax gourd seed extract, the polygonatum odoratum extract and the salvia miltiorrhiza oil are adopted as raw materials and are proportioned by proper weight, and the medicines are combined to achieve the effects of clearing away heat and toxic materials, nourishing yin, moistening dryness, tonifying spleen and nourishing blood; during preparation, part of the raw materials are firstly taken to be heated and dissolved, then the remaining raw materials are added to be stirred and mixed evenly, finally filtering and discharging are conducted, and the traditional Chinese medicine lipstick is prepared and obtained and has the effects of being natural and clear, effectively relieving lip tightening and peeling phenomena and the like and has the anti-inflammatory, repairing, nourishing and moisturizing effects on lips.

Description

Technical Field

[0001] The invention belongs to the technical field of lipsticks, and particularly relates to a traditional Chinese medicine lipstick for treating chronic cheilitis and a preparation method thereof. Background Art

[0002] Chronic cheilitis is also known as exfoliative cheilitis and chronic actinic cheilitis. It is characterized by dryness, desquamation, exudation, scabs, congestion and edema. The main manifestation is repeated attacks, sometimes severe and sometimes mild, and it persists. Conscious swelling, itching, burning pain, these symptoms often run through the entire course of the disease. Chronic recurrent attacks, swelling and exudation, inflammatory infiltration, forming a persistent lymphatic reflux disorder. The lip swelling persists. Chronic repeated infection can also lead to lymphatic tissue hyperplasia. The red part of the lower lip is a common site, with light yellow dry scabs, surrounded by grayish white scales, and mild congestion around the edges. Local dryness, swelling and itching, so people often lick their lips with their tongues, rub their lips with their hands, and bite their lips with their teeth, which causes lip ulcers and fissures, bleeding exudates, infection and pain, and scabs attached, swelling becomes more obvious, congestion and inflammation worsen, and even affect lip movement. It brings great pain to patients and affects their image.

[0003] The treatment of chronic cheilitis lacks a unified standard at present. According to literature reports, the clinical treatment of chronic cheilitis is varied, mostly using local external ointment or local combined systemic medication, such as glucocorticoids, immunomodulators, antibiotics, vitamins, antihistamines, moisturizers, laser therapy, microwave therapy, or taking active maintenance therapy, etc. Common methods include topical glucocorticoid ointments, such as desonide cream, hydrocortisone butyrate cream, mometasone furoate cream, fluocinolone ointment, etc. The mechanism of action of hormone drugs is that they can shrink the blood vessels of local skin lesions, increase the tension of local blood vessels, thereby reducing the permeability of blood vessels, play an anti-inflammatory effect, and inhibit local inflammatory reactions. Because it exerts a fast curative effect, it is widely used in clinical practice. However, the recurrence rate is high after hormone withdrawal, and long-term use can cause adverse reactions such as atrophy and pigmentation of local skin. Or use macrolide immunomodulators, such as the calcineurin inhibitor tacrolimus ointment. Currently, 0.1% and 0.03% tacrolimus are mainly used in clinical practice. Its clinical effects are to exert immunosuppression, antipruritic, anti-inflammatory and other effects, and it can also promote the synthesis of local skin collagen. However, relevant literature reports that tacrolimus ointment has the effect of promoting melanin deposition. Long-term use will produce abnormal dark spots on the lips, which will aggravate the patient's negative emotions. Therefore, there is still a lack of a relatively safe and effective targeted treatment method. Summary of the invention

[0004] In order to solve the above problems existing in the prior art, the present invention provides a Chinese medicine lipstick for treating chronic cheilitis, which is mild and safe, highly moisturizing, anti-inflammatory and soothing, and provides long-lasting protection and helps improve psychological comfort, and a preparation method thereof. The Chinese medicine lipstick of the present invention has the effects of natural clarity, effectively reducing lip tightness and peeling, and has the effects of anti-inflammatory, repairing, nourishing and moisturizing the lips.

[0005] The technical solution adopted by the present invention is: The first aspect of the present invention provides a Chinese medicinal lipstick for treating chronic cheilitis, wherein the effective ingredients of the raw materials include: Coconut oil, 2-4 parts by weight; Licorice extract, 0.2-0.4 parts by weight; Sweet almond oil, 0.1-0.3 parts by weight; Peach kernel oil, 0.1-0.3 parts by weight; Sweet almond (PRUNUS AMYGDALUS DULCIS) oil, 0.1-0.3 parts by weight; Wax gourd seed extract, 0.05-0.15 parts by weight; Polygonatum odoratum extract, 0.05-0.15 parts by weight; Salvia miltiorrhiza oil, 0.1-0.3 parts by weight.

[0006] Preferably, the raw material active ingredients of the Chinese medicine lipstick for treating chronic cheilitis include: Coconut oil, 3 parts by weight; Licorice extract, 0.3 parts by weight; Sweet almond oil, 0.2 parts by weight; Peach kernel oil, 0.2 parts by weight; Sweet almond oil, 0.2 parts by weight; Wax gourd seed extract, 0.1 parts by weight; Polygonatum odoratum extract, 0.1 parts by weight; Salvia miltiorrhiza oil, 0.2 parts by weight.

[0007] Preferably, the salvia miltiorrhiza oil is salvia miltiorrhiza oil.

[0008] Preferably, the raw materials of the Chinese medicine lipstick also include auxiliary ingredients.

[0009] Preferably, the auxiliary ingredients include ethylhexyl palmitate, polyisobutene, beeswax, caprylic / capric triglyceride, bis-diglyceryl polyacyl adipate-2, octyldodecanol, tridecyl trimellitate, hydrogenated polyisobutene, synthetic wax, dipentaerythrityl hexahydroxystearate / hexastearate / hexarosinate, EUPHORBIACERIFERA wax, BUTYROSPERMUM PARKII fruit butter, phytosteryl oleate, stearyl glycyrrhetinate, pentaerythrityl tetra(di-tert-butyl hydroxyhydrocinnamate), glyceryl caprylate, bisabolol, tocopheryl acetate, glyceryl tri(ethylhexanoate), and tocopherol (vitamin E).

[0010] Preferably, the auxiliary ingredients include 25 parts by weight of ethylhexyl palmitate, 15 parts by weight of polyisobutylene, 13 parts by weight of beeswax, 6 parts by weight of caprylic / capric triglyceride, 5 parts by weight of bis-diglycerol polyacyl adipate-2, 5 parts by weight of octyldodecanol, 5 parts by weight of tridecyl trimellitate, 5 parts by weight of hydrogenated polyisobutylene, 4.6 parts by weight of synthetic wax, 4 parts by weight of dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, 4 parts by weight of candelilla wax, 4 parts by weight of shea butter. PARKII) fruit fat 3 parts by weight, phytosteryl oleate 0.2 parts by weight, stearyl glycyrrhetinate 0.2 parts by weight, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate) ester 0.2 parts by weight, glyceryl caprylate 0.2 parts by weight, bisabolol 0.1 parts by weight, tocopherol acetate 0.1 parts by weight, glyceryl tri(ethylhexanoate) ester 0.05 parts by weight, vitamin E 0.05 parts by weight.

[0011] The second aspect of the present invention provides a method for preparing the Chinese medicinal lipstick for treating chronic cheilitis, comprising the following steps: (a) Take ethylhexyl palmitate, polyisobutene, beeswax, caprylic / capric triglyceride, bis-diglyceryl polyacyl adipate-2, octyldodecanol, tridecyl trimellitate, hydrogenated polyisobutene, synthetic wax, dipentaerythrityl hexahydroxystearate / hexastearate / hexarosinate, Euphorbia cerebroside wax, Butyrospermum parkii butter, pentaerythrityl tetra(di-tert-butyl hydroxyhydrocinnamate), and glyceryl caprylate in parts by weight, add them to an emulsifying pot, and heat under stirring until they are completely dissolved; (b) After cooling, take the remaining raw materials, add them into the emulsifying pot in sequence, and mix them thoroughly and stir them evenly; (c) filtering the material obtained in step (b) to obtain the Chinese medicinal lipstick for treating chronic cheilitis.

[0012] Preferably, in step (a), the stirring is ultrasonic stirring, the ultrasonic stirring condition is 15-20KHz, the stirring time is 30-45 minutes, and the heating temperature is 95-100°C; In step (b), the stirring is ultrasonic stirring, the ultrasonic stirring condition is 10-15KHz, and the stirring time is 20-30 minutes; In step (c), the filtration is performed using a 100-mesh filter.

[0013] Preferably, in step (b), the cooling is carried out in a staged cooling manner. In the first stage, the temperature is reduced from 95-100°C to 85°C at a cooling rate of 1°C per minute; in the second stage, the temperature is reduced from 85°C to 80°C at a cooling rate of 1°C per minute; in the third stage, the temperature is reduced from 80°C to 75°C at a cooling rate of 1°C per minute.

[0014] The inventors of the present application have found in long-term research that the use of ultrasonic stirring under limited conditions in lipstick production has the following advantages: (1) Uniform dispersion: Ultrasonic stirring can effectively disperse and evenly mix the various ingredients in the lipstick, ensuring the consistency of the ingredients of each batch of products and improving product quality; (2) Rapid dissolution: Through the cavitation effect of ultrasound, the solid ingredients and wax substances in the lipstick can be dissolved more quickly, shortening the production time and improving production efficiency; (3) Improved texture: Ultrasonic stirring can refine the particles and improve the texture of the lipstick, making it smoother and more delicate, thereby enhancing the user experience; (4) Enhanced stability: Uniform mixing and dispersion help improve the stability of the lipstick, reduce stratification or crystallization, and extend the shelf life of the product; (5) Reduced temperature requirements: Since ultrasound can promote dissolution and mixing, it is not necessary to heat to a very high temperature during the production process, thereby protecting heat-sensitive ingredients and maintaining their activity and efficacy; (6) Reduced use of additives: By improving mixing efficiency, the dependence on emulsifiers and stabilizers can be reduced, and a more natural product can be produced.

[0015] The inventors of the present application have also found in long-term research that the use of a segmented cooling strategy in lipstick production has the following advantages: (1) Improving product stability. By gradually lowering the temperature, the crystallization process of each component in the lipstick can be better controlled, stratification or uneven crystallization can be prevented, and the stability and consistency of the product can be improved; (2) Improving texture and appearance. Segmented cooling helps to form a uniform microstructure, making the texture of the lipstick more delicate and smooth, and improving the product's appearance quality and user experience; (3) Reducing stress and cracks. A slow and uniform cooling process can reduce the thermal stress inside the lipstick and reduce the risk of cracks or other physical defects; (4) Optimizing ingredient performance. Certain active ingredients are more stable within a specific temperature range. Segmented cooling can ensure that these ingredients are cured under optimal conditions and maintain their efficacy; (5) Saving energy and reducing consumption. By optimizing the cooling curve, unnecessary energy consumption can be reduced, production efficiency can be improved, and production costs can be reduced at the same time; (6) Improving production flexibility. The segmented cooling strategy can be adjusted according to different formulas and product requirements, providing greater process flexibility to adapt to diversified product lines.

[0016] Coconut oil can protect skin, moisturize skin, protect against the sun, and cleanse the face. Coconut oil contains the unique life tension of tropical plants, which can lift the tightness between cells, strengthen the contraction ability of pores, help remove the outer layer of dead skin cells, and restore damaged skin.

[0017] Licorice, sweet in taste, neutral in nature, belongs to the heart, lung, spleen and stomach meridians, and has the effects of clearing heat and detoxifying, tonifying the spleen and replenishing qi, and harmonizing various medicines. Modern pharmacological research shows that licorice has multiple effects such as anti-inflammatory, antibacterial, antiviral, anti-tumor, and antioxidant.

[0018] Apricot kernels are bitter and slightly warm in nature. They belong to the lung and large intestine meridians. They have the functions of lowering qi, relieving cough and asthma, moistening the intestines and relieving constipation. The Ben Jing says that it is used to treat "milk sores". Qian Jin Fang says that it is used to treat nasal sores. Sweet almond oil has a very low solidification point. It can still remain in a clear liquid state at -10°C and only solidifies at -20°C. Therefore, sweet almond oil is a raw material for making high-end cosmetics.

[0019] Peach kernel is bitter and neutral in nature. It has the functions of promoting blood circulation, removing blood stasis, moistening the intestines and relieving constipation. Modern pharmacological research has confirmed that peach kernel contains fatty oil, and the alcohol extract of peach kernel has an anti-coagulation effect.

[0020] The vitamin E and various amino acids rich in wax gourd seeds can moisturize the skin and prevent skin dryness and aging.

[0021] Polygonatum odoratum is sweet in taste and slightly cold in nature. It belongs to the lung and stomach meridians and has the effects of nourishing yin and moistening dryness, promoting body fluid and quenching thirst. Its chemical components are mainly steroidal isoflavones, saponins, volatile oils, polysaccharides, etc., and polysaccharides are its main active ingredients. According to current medical research, Polygonatum odoratum polysaccharides mainly have the effects of anti-oxidation, lowering blood sugar and regulating immunity, and are widely used in the prevention and treatment of various diseases and in the field of medical care.

[0022] Salvia miltiorrhiza oil has antioxidant effects, reduces the damage of free radicals to the skin, delays skin aging, and makes the skin firmer and more elastic.

[0023] The present invention has the following beneficial effects: The invention provides a Chinese medicine lipstick for treating chronic cheilitis. The lipstick adopts coconut oil, licorice extract, sweet almond oil, peach kernel oil (also called peach kernel oil), wax gourd seed extract, polygonatum extract, and salvia miltiorrhiza oil as raw materials and performs appropriate weight ratio. The licorice has the effects of anti-inflammatory, antibacterial, clearing heat and detoxifying, tonifying spleen and replenishing qi, and harmonizing various medicines. The fatty oil contained in bitter almond can soften the stratum corneum of the skin, moisturize the skin, protect nerve endings, blood vessels and tissues and organs, and inhibit bacteria. In addition, HCN generated by enzyme hydrolysis can inhibit active tyrosinase in the body, eliminate pigmentation, freckles, black spots, etc., so as to achieve a cosmetic effect. Polygonatum polysaccharide contained in polygonatum has the effects of anti-oxidation, lowering blood sugar, regulating immunity, etc., and can be applied to the prevention and treatment of various diseases and the field of medical care. Peach kernel contains fatty oil, and the alcohol extract of peach kernel has the effect of anti-coagulation. Peach kernel powder is applied to the lesion, and it is absorbed and penetrated by the skin, promoting local blood circulation, accelerating local blood flow rate, promoting blood circulation and qi circulation, relieving qi and blood stagnation, eliminating blood circulation wind, and curing lip wind. Coconut oil can lift the tightness between cells, strengthen the contraction ability of pores, help remove the outer layer of dead skin cells, restore damaged skin, make the junction of the epidermis and dermis of the skin healthier and smoother, generate new skin cells, improve dry and allergic skin, and relieve lip cracking. The above medicines are used together to play the effects of clearing away heat and detoxification, nourishing yin and moisturizing dryness, and strengthening the spleen and nourishing blood. The Chinese medicine lipstick of the present invention has the effects of natural clarity, effectively reducing the tightness and peeling of the lips, and playing the role of anti-inflammatory, repairing, nourishing and moisturizing the lips. DETAILED DESCRIPTION

[0024] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0025] Unless otherwise specified, the reagents involved in the specific embodiments of the present invention are all commercially available products and can be purchased through commercial channels.

[0026] In the following examples, 1 part by weight represents 1 g.

[0027] Example 1 The present embodiment provides a Chinese medicine lipstick for treating chronic cheilitis, wherein the raw material components include effective ingredients and auxiliary ingredients; wherein the effective ingredients are: 2 parts by weight of coconut oil, 0.4 parts by weight of licorice extract, 0.1 parts by weight of sweet almond oil, 0.3 parts by weight of peach kernel oil, 0.05 parts by weight of wax gourd seed extract, 0.15 parts by weight of polygonatum odoratum extract, 0.1 parts by weight of salvia miltiorrhiza oil, and 0.3 parts by weight of sweet almond (PRUNUS AMYGDALUS DULCIS) oil.

[0028] The auxiliary ingredients are as follows: 25 parts by weight of ethylhexyl palmitate, 15 parts by weight of polyisobutene, 13 parts by weight of beeswax, 6 parts by weight of caprylic / capric triglyceride, 5 parts by weight of bis-diglyceryl polyacyl adipate-2, 5 parts by weight of octyldodecanol, 5 parts by weight of tridecanol trimellitate, 5 parts by weight of hydrogenated polyisobutene, 4.6 parts by weight of synthetic wax, 4 parts by weight of dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, 4 parts by weight of candelilla (EUPHORBIA CERIFERA) wax, 4 parts by weight of avocado tree (BUTYROSPERMUM PARKII) fruit fat 3 parts by weight, phytosteryl oleate 0.2 parts by weight, stearyl glycyrrhetinate 0.2 parts by weight, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate) ester 0.2 parts by weight, glyceryl caprylate 0.2 parts by weight, bisabolol 0.1 parts by weight, tocopherol acetate 0.1 parts by weight, glyceryl tri(ethylhexanoate) ester 0.05 parts by weight, tocopherol (vitamin E) 0.05 parts by weight.

[0029] Among them, licorice extract, wax gourd seed extract and polygonatum odoratum extract are prepared by the following method: Licorice, wax gourd seeds and polygonatum were crushed separately, then extracted with 70% ethanol by reflux, the extracts were combined and concentrated under reduced pressure; purified by HPD100 macroporous resin, 70% ethanol eluate was collected, concentrated and dried to obtain respective extracts.

[0030] The preparation method of the Chinese medicinal lipstick for treating chronic cheilitis is as follows: (a) Take ethylhexyl palmitate, polyisobutene, beeswax, caprylic / capric triglyceride, bis-diglyceryl polyacyl adipate-2, octyldodecanol, tridecyl trimellitate, hydrogenated polyisobutene, synthetic wax, dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, Euphorbia cerebroside wax, Butyrospermum parkii fruit butter, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate), and glyceryl caprylate in parts by weight, add them to an emulsifying pot, turn on ultrasonic stirring at 15 kHz for 45 minutes, and heat to 95° C. until all ingredients are completely dissolved; (b) After cooling to 75°C by staged cooling, the remaining raw materials were added to the emulsification pot in batches, and ultrasonic stirring was turned on. The ultrasonic stirring condition was 10KHz and the stirring time was 30 minutes; The segmented cooling is carried out in three stages: in the first stage, the temperature is reduced from 95°C to 85°C at a cooling rate of 1°C per minute; in the second stage, the temperature is reduced from 85°C to 80°C at a cooling rate of 1°C per minute; in the third stage, the temperature is reduced from 80°C to 75°C at a cooling rate of 1°C per minute; (c) the material obtained in step (b) is filtered out through a 100-mesh filter and packaged in batches to obtain the Chinese medicinal lipstick for treating chronic cheilitis.

[0031] Example 2 The present embodiment provides a Chinese medicine lipstick for treating chronic cheilitis, wherein the raw material components include effective ingredients and auxiliary ingredients; wherein the effective ingredients are: 4 parts by weight of coconut oil, 0.2 parts by weight of licorice extract, 0.3 parts by weight of sweet almond oil, 0.1 parts by weight of peach kernel oil, 0.15 parts by weight of wax gourd seed extract, 0.05 parts by weight of polygonatum odoratum extract, 0.3 parts by weight of salvia miltiorrhiza oil, and 0.1 parts by weight of sweet almond (PRUNUS AMYGDALUS DULCIS) oil.

[0032] The auxiliary ingredients are as follows: 25 parts by weight of ethylhexyl palmitate, 15 parts by weight of polyisobutene, 13 parts by weight of beeswax, 6 parts by weight of caprylic / capric triglyceride, 5 parts by weight of bis-diglyceryl polyacyl adipate-2, 5 parts by weight of octyldodecanol, 5 parts by weight of tridecanol trimellitate, 5 parts by weight of hydrogenated polyisobutene, 4.6 parts by weight of synthetic wax, 4 parts by weight of dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, 4 parts by weight of candelilla (EUPHORBIA CERIFERA) wax, 4 parts by weight of avocado tree (BUTYROSPERMUM PARKII) fruit fat 3 parts by weight, phytosteryl oleate 0.2 parts by weight, stearyl glycyrrhetinate 0.2 parts by weight, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate) ester 0.2 parts by weight, glyceryl caprylate 0.2 parts by weight, bisabolol 0.1 parts by weight, tocopherol acetate 0.1 parts by weight, glyceryl tri(ethylhexanoate) ester 0.05 parts by weight, tocopherol (vitamin E) 0.05 parts by weight.

[0033] The preparation method of the Chinese medicinal lipstick for treating chronic cheilitis is as follows: (a) Take ethylhexyl palmitate, polyisobutene, beeswax, caprylic / capric triglyceride, bis-diglyceryl polyacyl adipate-2, octyldodecanol, tridecyl trimellitate, hydrogenated polyisobutene, synthetic wax, dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, Euphorbia cerebroside wax, Butyrospermum parkii fruit butter, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate), and glyceryl caprylate in parts by weight, add them to an emulsifying pot, turn on ultrasonic stirring at 20 kHz for 30 minutes, and heat to 100°C until all ingredients are completely dissolved; (b) After cooling to 75°C by staged cooling, the remaining raw materials were added to the emulsifying pot in batches, and ultrasonic stirring was turned on. The ultrasonic stirring condition was 15KHz and the stirring time was 20 minutes; The segmented cooling is carried out in three stages: in the first stage, the temperature is reduced from 100°C to 85°C at a cooling rate of 1°C per minute; in the second stage, the temperature is reduced from 85°C to 80°C at a cooling rate of 1°C per minute; in the third stage, the temperature is reduced from 80°C to 75°C at a cooling rate of 1°C per minute; (c) the material obtained in step (b) is filtered out through a 100-mesh filter and packaged in batches to obtain the Chinese medicinal lipstick for treating chronic cheilitis.

[0034] Example 3 The present embodiment provides a traditional Chinese medicine lipstick for treating chronic cheilitis, wherein the raw material components include effective ingredients and auxiliary ingredients; wherein the effective ingredients are: 3 parts by weight of coconut oil, 0.3 parts by weight of licorice extract, 0.2 parts by weight of sweet almond oil, 0.2 parts by weight of peach kernel oil, 0.1 parts by weight of wax gourd seed extract, 0.1 parts by weight of polygonatum odoratum extract, 0.2 parts by weight of salvia miltiorrhiza oil, and 0.2 parts by weight of sweet almond (PRUNUS AMYGDALUS DULCIS) oil.

[0035] The auxiliary ingredients are as follows: 25 parts by weight of ethylhexyl palmitate, 15 parts by weight of polyisobutene, 13 parts by weight of beeswax, 6 parts by weight of caprylic / capric triglyceride, 5 parts by weight of bis-diglyceryl polyacyl adipate-2, 5 parts by weight of octyldodecanol, 5 parts by weight of tridecanol trimellitate, 5 parts by weight of hydrogenated polyisobutene, 4.6 parts by weight of synthetic wax, 4 parts by weight of dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, 4 parts by weight of candelilla (EUPHORBIA CERIFERA) wax, 4 parts by weight of avocado tree (BUTYROSPERMUM PARKII) fruit fat 3 parts by weight, phytosteryl oleate 0.2 parts by weight, stearyl glycyrrhetinate 0.2 parts by weight, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate) ester 0.2 parts by weight, glyceryl caprylate 0.2 parts by weight, bisabolol 0.1 parts by weight, tocopherol acetate 0.1 parts by weight, glyceryl tri(ethylhexanoate) ester 0.05 parts by weight, tocopherol (vitamin E) 0.05 parts by weight.

[0036] The preparation method of the Chinese medicinal lipstick for treating chronic cheilitis is as follows: (a) Take ethylhexyl palmitate, polyisobutene, beeswax, caprylic / capric triglyceride, bis-diglyceryl polyacyl adipate-2, octyldodecanol, tridecyl trimellitate, hydrogenated polyisobutene, synthetic wax, dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, candelilla (EUPHORBIA CERIFERA) wax, shea (BUTYROSPERMUM PARKII) fruit butter, pentaerythritol tetra (di-tert-butyl hydroxyhydrocinnamate), glyceryl caprylate in parts by weight, add them to an emulsifier, turn on ultrasonic stirring, the ultrasonic stirring condition is 18KHz, the stirring time is 40 minutes, and heat to 98°C until all the ingredients are completely dissolved; (b) After cooling to 75°C by staged cooling, the remaining raw materials were added to the emulsification pot in batches, and ultrasonic stirring was turned on. The ultrasonic stirring condition was 12KHz and the stirring time was 25 minutes; The segmented cooling is carried out in three stages: in the first stage, the temperature is reduced from 98°C to 85°C at a cooling rate of 1°C per minute; in the second stage, the temperature is reduced from 85°C to 80°C at a cooling rate of 1°C per minute; in the third stage, the temperature is reduced from 80°C to 75°C at a cooling rate of 1°C per minute; (c) the material obtained in step (b) is filtered out through a 100-mesh filter and packaged in batches to obtain the Chinese medicinal lipstick for treating chronic cheilitis.

[0037] Comparative Example 1 The difference between this comparative example and Example 3 is only the raw material components. No licorice extract is added to the raw material components of this comparative example, and the amounts of other raw materials and the preparation method are the same as those in Example 3.

[0038] Comparative Example 2 The difference between this comparative example and Example 3 is only the raw material components. No wax gourd seed extract is added to the raw material components of this comparative example, and the amounts of other raw materials and the preparation methods are the same as those in Example 3.

[0039] Comparative Example 3 The difference between this comparative example and Example 3 is only the raw material components. No Polygonatum odoratum extract is added to the raw material components of this comparative example, and the amounts of other raw materials and the preparation methods are the same as those in Example 3.

[0040] Comparative Example 4 The difference between this comparative example and Example 3 is only the raw material composition. No sweet almond oil is added to the raw material components of this comparative example, and the amount of other raw materials and the preparation method are the same as those in Example 3.

[0041] Comparative Example 5 The difference between this comparative example and Example 3 is only the raw material composition. No peach kernel oil is added to the raw material components of this comparative example, and the amounts of other raw materials and the preparation method are the same as those in Example 3.

[0042] Comparative Example 6 The difference between this comparative example and Example 3 is only the raw material composition. No sweet almond oil is added to the raw material components of this comparative example, and the amount of other raw materials and the preparation method are the same as those in Example 3.

[0043] Comparative Example 7 The difference between this comparative example and Example 3 is only the raw material components. Salvia miltiorrhiza oil is not added to the raw material components of this comparative example, and the amounts of other raw materials and the preparation method are the same as those in Example 3.

[0044] Comparative Example 8 The difference between this comparative example and Example 3 is only the preparation method. In step (b) of the preparation method of this comparative example, the segmented cooling method is not adopted, and the other operation steps are the same as those of Example 3.

[0045] Experimental example The clinical efficacy and safety of the Chinese medicinal lipstick obtained in Examples 1-3 for the treatment of chronic cheilitis were evaluated. The specific method is: 110 volunteers with cheilitis were selected and randomly divided into 11 groups, each with 10 cases, and the Chinese medicinal lipstick obtained in Examples 1-3 and the lipstick obtained in Comparative Examples 1-8 were used respectively. After 8 weeks of treatment, the skin lesion repair score, clinical manifestation and effect score, subjective symptoms and effect score of patients in different groups were compared, with a full score of 10. The results are shown in Table 1.

[0046] Table 1- Ratings of the use effects of different lipsticks

[0047] As can be seen from Table 1, the Chinese medicine lipsticks of Examples 1 to 3 have good therapeutic effects on lip rash and are relatively safe. The patient experience (self-perceived effect) is good, and the skin lesion range repair score, clinical manifestation and effect score, and subjective symptom and effect score are all greater than 9.7 points. Among them, the Chinese medicine lipstick obtained in Example 3 has the highest score, indicating that under the component ratio of Example 3, the raw material components work synergistically, so that the effect of the obtained Chinese medicine lipstick is optimal. However, when one of the raw material components in the above raw materials is removed or a key step in the preparation method is adjusted, the scores of the obtained Chinese medicine lipstick comparative examples (1-8) are relatively low, the efficacy on lip rash is relatively poor, and the patient experience after use is not good.

[0048] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A Chinese medicinal lipstick for treating chronic cheilitis, characterized in that: The active ingredients of raw materials include: Coconut oil, 2-4 parts by weight; Licorice extract, 0.2-0.4 parts by weight; Sweet almond oil, 0.1-0.3 parts by weight; Peach kernel oil, 0.1-0.3 parts by weight; Sweet almond oil, 0.1-0.3 parts by weight; Wax gourd seed extract, 0.05-0.15 parts by weight; Polygonatum odoratum extract, 0.05-0.15 parts by weight; Salvia miltiorrhiza oil, 0.1-0.3 parts by weight.

2. The Chinese medicinal lipstick for treating chronic cheilitis according to claim 1, characterized in that: The active ingredients of raw materials include: Coconut oil, 3 parts by weight; Licorice extract, 0.3 parts by weight; Sweet almond oil, 0.2 parts by weight; Peach kernel oil, 0.2 parts by weight; Sweet almond oil, 0.2 parts by weight; Wax gourd seed extract, 0.1 parts by weight; Polygonatum odoratum extract, 0.1 parts by weight; Salvia miltiorrhiza oil, 0.2 parts by weight.

3. The Chinese medicinal lipstick for treating chronic cheilitis according to claim 1, characterized in that: The salvia miltiorrhiza oil is European salvia miltiorrhiza oil.

4. The Chinese medicinal lipstick for treating chronic cheilitis according to claim 1, characterized in that: Raw materials also include auxiliary ingredients.

5. The Chinese medicinal lipstick for treating chronic cheilitis according to claim 4, characterized in that: The auxiliary ingredients include ethylhexyl palmitate, polyisobutene, beeswax, caprylic / capric triglyceride, bis-diglyceryl polyacyl adipate-2, octyldodecanol, tridecyl trimellitate, hydrogenated polyisobutene, synthetic wax, dipentaerythrityl hexahydroxystearate / hexastearate / hexarosinate, candelilla wax, shea butter, phytosteryl oleate, stearyl glycyrrhetinate, pentaerythrityl tetra(di-tert-butyl hydroxyhydrocinnamate), glyceryl caprylate, bisabolol, tocopheryl acetate, glyceryl tri(ethylhexanoate), and vitamin E.

6. The Chinese medicinal lipstick for treating chronic cheilitis according to claim 5, characterized in that: The auxiliary material ingredients include 25 parts by weight of ethylhexyl palmitate, 15 parts by weight of polyisobutene, 13 parts by weight of beeswax, 6 parts by weight of caprylic / capric triglyceride, 5 parts by weight of bis-diglyceryl polyacyl adipate-2, 5 parts by weight of octyldodecanol, 5 parts by weight of tridecanol trimellitate, 5 parts by weight of hydrogenated polyisobutene, 4.6 parts by weight of synthetic wax, 4 parts by weight of dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, 4 parts by weight of candelilla wax, 3 parts by weight of avocado tree butter, 0.2 parts by weight of phytosteryl oleate, 0.2 parts by weight of stearyl glycyrrhetinate, 0.2 parts by weight of pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate), 0.2 parts by weight of glyceryl caprylate, 0.1 parts by weight of bisabolol, 0.1 parts by weight of tocopherol acetate, 0.05 parts by weight of tri(ethylhexanoic acid)glyceryl, and 0.05 parts by weight of vitamin E.

7. The method for preparing the Chinese medicinal lipstick for treating chronic cheilitis according to any one of claims 1 to 6, characterized in that: The steps include: (a) Take ethylhexyl palmitate, polyisobutene, beeswax, caprylic / capric triglyceride, bis-diglyceryl polyacyl adipate-2, octyldodecanol, tridecyl trimellitate, hydrogenated polyisobutene, synthetic wax, dipentaerythritol hexahydroxystearate / hexastearate / hexarosinate, candelilla wax, shea butter, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate), and glyceryl caprylate in parts by weight, add them to an emulsifying pot, and heat under stirring until they are completely dissolved; (b) After cooling, take the remaining raw materials, add them into the emulsifying pot in sequence, and mix them thoroughly and stir them evenly; (c) filtering the material obtained in step (b) to obtain the Chinese medicinal lipstick for treating chronic cheilitis.

8. The method for preparing the Chinese medicinal lipstick for treating chronic cheilitis according to claim 7, characterized in that: In step (a), the stirring is ultrasonic stirring, the ultrasonic stirring condition is 15-20KHz, the stirring time is 30-45 minutes, and the heating temperature is 95-100°C; In step (b), the stirring is ultrasonic stirring, the ultrasonic stirring condition is 10-15KHz, and the stirring time is 20-30 minutes.

9. The method for preparing the Chinese medicinal lipstick for treating chronic cheilitis according to claim 7, characterized in that: In step (c), the filtration is performed using a 100-mesh filter.

10. The method for preparing the Chinese medicinal lipstick for treating chronic cheilitis according to claim 8, characterized in that: In step (b), the temperature is lowered in stages. In the first stage, the temperature is lowered from 95-100°C to 85°C at a rate of 1°C per minute. In the second stage, the temperature was lowered from 85°C to 80°C at a rate of 1°C per minute; in the third stage, the temperature was lowered from 80°C to 75°C at a rate of 1°C per minute.

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